Francesca Belleudi

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. doi request reprint Hrs regulates the endocytic sorting of the fibroblast growth factor receptor 2b
    Francesca Belleudi
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Medicina Sperimentale, Universita di Roma La Sapienza, Rome, Italy
    Exp Cell Res 315:2181-91. 2009
  2. pmc The receptor tyrosine kinase FGFR2b/KGFR controls early differentiation of human keratinocytes
    Francesca Belleudi
    Dipartimento di Medicina Clinica e Molecolare, Istituto Pasteur Fondazione Cenci Bolognetti, Sapienza Universita di Roma, Rome, Italy
    PLoS ONE 6:e24194. 2011
  3. ncbi request reprint Ligand-induced clathrin-mediated endocytosis of the keratinocyte growth factor receptor occurs independently of either phosphorylation or recruitment of eps15
    Francesca Belleudi
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Viale Regina Elena 324, 00161 Rome, Italy
    FEBS Lett 553:262-70. 2003
  4. ncbi request reprint Keratinocyte growth factor receptor ligands target the receptor to different intracellular pathways
    Francesca Belleudi
    Dipartimento di Medicina Sperimentale, Universita di Roma La Sapienza, Viale Regina Elena 324, 00161 Roma, Italy
    Traffic 8:1854-72. 2007
  5. ncbi request reprint Endocytic pathways and biological effects induced by UVB-dependent or ligand-dependent activation of the keratinocyte growth factor receptor
    Francesca Belleudi
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Rome, Italy
    FASEB J 20:395-7. 2006
  6. ncbi request reprint Differential response to keratinocyte growth factor receptor and epidermal growth factor receptor ligands of proliferating and differentiating intestinal epithelial cells
    Vincenzo Visco
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Roma, Italy
    J Cell Physiol 200:31-44. 2004
  7. pmc Polarized endocytosis of the keratinocyte growth factor receptor in migrating cells: role of SRC-signaling and cortactin
    Francesca Belleudi
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Roma, Italy
    PLoS ONE 6:e29159. 2011
  8. ncbi request reprint Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis
    Mara Ceridono
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Rome, Italy
    Biochem Biophys Res Commun 327:523-32. 2005
  9. ncbi request reprint The endocytic pathway followed by the keratinocyte growth factor receptor
    Francesca Belleudi
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Viale Regina Elena 324, 00161 Rome, Italy
    Histochem Cell Biol 118:1-10. 2002
  10. ncbi request reprint CIN85 regulates the ligand-dependent endocytosis of the IgE receptor: a new molecular mechanism to dampen mast cell function
    Rosa Molfetta
    Department of Experimental Medicine and Pathology, Institute Pasteur Fondazione Cenci Bolognetti, University La Sapienza, Rome, Italy
    J Immunol 175:4208-16. 2005

Collaborators

Detail Information

Publications22

  1. doi request reprint Hrs regulates the endocytic sorting of the fibroblast growth factor receptor 2b
    Francesca Belleudi
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Medicina Sperimentale, Universita di Roma La Sapienza, Rome, Italy
    Exp Cell Res 315:2181-91. 2009
    ..In addition, the results suggest that Hrs recruitment to the receptor, but not its ligand-induced phosphorylation, could be required for its function...
  2. pmc The receptor tyrosine kinase FGFR2b/KGFR controls early differentiation of human keratinocytes
    Francesca Belleudi
    Dipartimento di Medicina Clinica e Molecolare, Istituto Pasteur Fondazione Cenci Bolognetti, Sapienza Universita di Roma, Rome, Italy
    PLoS ONE 6:e24194. 2011
    ..This in vitro experimental model indicates that FGFR2b/KGFR expression represents a key event regulating keratinocyte early differentiation during the switch from undifferentiated to differentiating cells...
  3. ncbi request reprint Ligand-induced clathrin-mediated endocytosis of the keratinocyte growth factor receptor occurs independently of either phosphorylation or recruitment of eps15
    Francesca Belleudi
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Viale Regina Elena 324, 00161 Rome, Italy
    FEBS Lett 553:262-70. 2003
    ..Taken together our results indicate that the clathrin-mediated uptake of KGFR is not mediated by eps15...
  4. ncbi request reprint Keratinocyte growth factor receptor ligands target the receptor to different intracellular pathways
    Francesca Belleudi
    Dipartimento di Medicina Sperimentale, Universita di Roma La Sapienza, Viale Regina Elena 324, 00161 Roma, Italy
    Traffic 8:1854-72. 2007
    ....
  5. ncbi request reprint Endocytic pathways and biological effects induced by UVB-dependent or ligand-dependent activation of the keratinocyte growth factor receptor
    Francesca Belleudi
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Rome, Italy
    FASEB J 20:395-7. 2006
    ....
  6. ncbi request reprint Differential response to keratinocyte growth factor receptor and epidermal growth factor receptor ligands of proliferating and differentiating intestinal epithelial cells
    Vincenzo Visco
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Roma, Italy
    J Cell Physiol 200:31-44. 2004
    ....
  7. pmc Polarized endocytosis of the keratinocyte growth factor receptor in migrating cells: role of SRC-signaling and cortactin
    Francesca Belleudi
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Roma, Italy
    PLoS ONE 6:e29159. 2011
    ..Our results indicate that both Src and cortactin play a key role in the KGFR endocytosis and polarization at the leading edge of migrating keratinocytes, supporting the crucial involvement of RTK trafficking in cell motility...
  8. ncbi request reprint Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis
    Mara Ceridono
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Rome, Italy
    Biochem Biophys Res Commun 327:523-32. 2005
    ..Our data also show that tyrosine 769 is not involved in the regulation of the endocytic process of KGFR...
  9. ncbi request reprint The endocytic pathway followed by the keratinocyte growth factor receptor
    Francesca Belleudi
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Viale Regina Elena 324, 00161 Rome, Italy
    Histochem Cell Biol 118:1-10. 2002
    ..Pulse-chase experiments showed that the internalized KGFRs underwent degradation detectable at 1 h of endocytosis at 37 degrees C, indicating that KGFRs are functionally downregulated...
  10. ncbi request reprint CIN85 regulates the ligand-dependent endocytosis of the IgE receptor: a new molecular mechanism to dampen mast cell function
    Rosa Molfetta
    Department of Experimental Medicine and Pathology, Institute Pasteur Fondazione Cenci Bolognetti, University La Sapienza, Rome, Italy
    J Immunol 175:4208-16. 2005
    ..This role of CIN85 could be extended to include other multimeric immune receptors, such as the T and B cell receptors, providing a more general molecular mechanism for attenuating immune responses...
  11. ncbi request reprint The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation
    Jasminka Omerovic
    Department of Experimental Medicine and Pathology, University La Sapienza, Viale Regina Elena 324 00161, Rome, Italy
    FASEB J 21:2849-62. 2007
    ..These findings expand our understanding of the mechanisms contributing to the integrity of the ErbB signaling network and mechanistically link the cellular ubiquitination pathway of AIP4/Itch to the ErbB-4 receptor...
  12. pmc Activation of an early feedback survival loop involving phospho-ErbB3 is a general response of melanoma cells to RAF/MEK inhibition and is abrogated by anti-ErbB3 antibodies
    Luigi Fattore
    Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Rome, Italy
    J Transl Med 11:180. 2013
    ..However, also in this case resistance inevitably occurs. It has been recently reported that ErbB3, a member of the EGFR receptor family, may be involved in the establishment of drug resistance...
  13. doi request reprint Expression and signaling of the tyrosine kinase FGFR2b/KGFR regulates phagocytosis and melanosome uptake in human keratinocytes
    Francesca Belleudi
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Rome, Italy
    FASEB J 25:170-81. 2011
    ....
  14. ncbi request reprint UVB-induced activation and internalization of keratinocyte growth factor receptor
    Cinzia Marchese
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Viale Regina Elena 324, Rome 00161, Italy
    Oncogene 22:2422-31. 2003
    ....
  15. pmc The cooperation between hMena overexpression and HER2 signalling in breast cancer
    Francesca Di Modugno
    Experimental Chemotherapy, Regina Elena National Cancer Institute, Rome, Italy
    PLoS ONE 5:e15852. 2010
    ....
  16. ncbi request reprint Subcellular localization of the BRCA1 gene product in mitotic cells
    Lavinia Vittoria Lotti
    Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
    Genes Chromosomes Cancer 35:193-203. 2002
    ..These results are consistent with an involvement of BRCA1 in the dynamics of the mitotic spindle and in the segregation of duplicated chromosomes...
  17. doi request reprint Monoclonal antibody-induced ErbB3 receptor internalization and degradation inhibits growth and migration of human melanoma cells
    Francesca Belleudi
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Rome, Italy
    Cell Cycle 11:1455-67. 2012
    ..Our study confirms the key role of ErbB3 and points to exploitation of novel combination therapies for treatment of malignant melanoma...
  18. pmc KGF Promotes Paracrine Activation of the SCF/c-KIT Axis from Human Keratinocytes to Melanoma Cells
    Francesca Belleudi
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Rome, Italy
    Transl Oncol 3:80-90. 2010
    ....
  19. pmc Expression of HPV16 E5 down-modulates the TGFbeta signaling pathway
    Deborah French
    Istitute Pasteur Fondazione Cenci Bolognetti, Department of Clinical and Molecular Medicine, Sapienza University of Roma, and S Andrea Hospital, Rome, Italy
    Mol Cancer 12:38. 2013
    ....
  20. pmc HPV16 E5 and KGFR/FGFR2b interplay in differentiating epithelial cells
    Valeria Purpura
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Italy
    Oncotarget 4:192-205. 2013
    ....
  21. doi request reprint Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation
    Chiara Napoletano
    Department of Experimental Medicine, Sapienza University, Rome, Italy
    Eur J Immunol 42:936-45. 2012
    ..These results demonstrate that the targeting of MGL receptor on human DCs has an adjuvant effect and that this strategy can be used to design novel anticancer vaccines...
  22. pmc HER2-based recombinant immunogen to target DCs through FcγRs for cancer immunotherapy
    Ilaria Grazia Zizzari
    Department of Experimental Medicine, Sapienza University of Rome, Italy
    J Mol Med (Berl) 89:1231-40. 2011
    ....