Riccardo Bellazzi

Summary

Affiliation: University of Pavia
Country: Italy

Publications

  1. ncbi request reprint Big data and biomedical informatics: a challenging opportunity
    R Bellazzi
    Riccardo Bellazzi, Biomedical Informatics Labs Mario Stefanelli, Department of Electric, Computer and Biomedical Engineering, University of Pavia, Tel 39 0382 985720, 39 0382 985059, 39 0382, 985981, Fax 39 0382 985373, E mail
    Yearb Med Inform 9:8-13. 2014
  2. doi request reprint A probabilistic method for computing quantitative risk indexes from medical injuries compensation claims
    S Dalle Carbonare
    Riccardo Bellazzi, Dipartimento di Ingegneria Industriale e dell Informazione, Via Ferrata 1, 27100 Pavia PV, Italy, E mail
    Methods Inf Med 52:374-81. 2013
  3. pmc Clinical Bioinformatics: challenges and opportunities
    Riccardo Bellazzi
    Dipartimento di Ingegneria Industriale e dell Informazione, Universita di Pavia, Via Ferrata 1, 27100, Pavia, Italy
    BMC Bioinformatics 13:S1. 2012
  4. doi request reprint Supporting regenerative medicine by integrative dimensionality reduction
    F Mulas
    Centre for Tissue Engineering, University of Pavia, Pavia, Italy
    Methods Inf Med 51:341-7. 2012
  5. doi request reprint Implementation of an automated system for monitoring adherence to hemodialysis treatment: a report of seven years of experience
    Riccardo Bellazzi
    Dipartimento di Informatica e Sistemistica, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Int J Med Inform 81:320-31. 2012
  6. pmc Genetic association studies for gene expressions: permutation-based mutual information in a comparison with standard ANOVA and as a novel approach for feature selection
    Silke Szymczak
    Institute of Medical Biometry and Statistics, University Hospital Schleswig Holstein, , , Ratzeburger Allee 160, , Germany
    BMC Proc 1:S9. 2007
  7. pmc Gatekeeper of pluripotency: a common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells
    Maurizio Zuccotti
    Sezione di Istologia ed Embriologia, Dipartimento di Medicina Sperimentale, Universita degli Studi di Parma, Parma, Italy
    BMC Genomics 12:1-13. 2011
  8. pmc Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes
    Maurizio Zuccotti
    Sezione di Istologia ed Embriologia, Dipartimento di Medicina Sperimentale, Universita degli Studi di Parma, Parma, Italy
    BMC Dev Biol 8:97. 2008
  9. pmc A hierarchical Naïve Bayes Model for handling sample heterogeneity in classification problems: an application to tissue microarrays
    Francesca Demichelis
    Bionformatics, SRA, ITC irst and Dept of Information and Communication Technology, University of Trento, Trento, Italy
    BMC Bioinformatics 7:514. 2006
  10. pmc Phenotype forecasting with SNPs data through gene-based Bayesian networks
    Alberto Malovini
    IRCCS Multimedica, via Fantoli 16 15, I 20138 Milano, Italy
    BMC Bioinformatics 10:S7. 2009

Detail Information

Publications74

  1. ncbi request reprint Big data and biomedical informatics: a challenging opportunity
    R Bellazzi
    Riccardo Bellazzi, Biomedical Informatics Labs Mario Stefanelli, Department of Electric, Computer and Biomedical Engineering, University of Pavia, Tel 39 0382 985720, 39 0382 985059, 39 0382, 985981, Fax 39 0382 985373, E mail
    Yearb Med Inform 9:8-13. 2014
    ....
  2. doi request reprint A probabilistic method for computing quantitative risk indexes from medical injuries compensation claims
    S Dalle Carbonare
    Riccardo Bellazzi, Dipartimento di Ingegneria Industriale e dell Informazione, Via Ferrata 1, 27100 Pavia PV, Italy, E mail
    Methods Inf Med 52:374-81. 2013
    ..An important aspect of risk management is to exploit the analysis of medical injuries compensation claims in order to reduce adverse events and, at the same time, to optimize the costs of health insurance policies...
  3. pmc Clinical Bioinformatics: challenges and opportunities
    Riccardo Bellazzi
    Dipartimento di Ingegneria Industriale e dell Informazione, Universita di Pavia, Via Ferrata 1, 27100, Pavia, Italy
    BMC Bioinformatics 13:S1. 2012
    ....
  4. doi request reprint Supporting regenerative medicine by integrative dimensionality reduction
    F Mulas
    Centre for Tissue Engineering, University of Pavia, Pavia, Italy
    Methods Inf Med 51:341-7. 2012
    ..Here we show that these techniques can be further strengthened to support decision making with i) a novel strategy for gene selection; ii) methods for combining the evidence from multiple data sets...
  5. doi request reprint Implementation of an automated system for monitoring adherence to hemodialysis treatment: a report of seven years of experience
    Riccardo Bellazzi
    Dipartimento di Informatica e Sistemistica, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Int J Med Inform 81:320-31. 2012
    ..Failures-to-adhere (FtAs) to the planned treatment are detected and reported to the care-givers...
  6. pmc Genetic association studies for gene expressions: permutation-based mutual information in a comparison with standard ANOVA and as a novel approach for feature selection
    Silke Szymczak
    Institute of Medical Biometry and Statistics, University Hospital Schleswig Holstein, , , Ratzeburger Allee 160, , Germany
    BMC Proc 1:S9. 2007
    ..They merit further methodological investigation...
  7. pmc Gatekeeper of pluripotency: a common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells
    Maurizio Zuccotti
    Sezione di Istologia ed Embriologia, Dipartimento di Medicina Sperimentale, Universita degli Studi di Parma, Parma, Italy
    BMC Genomics 12:1-13. 2011
    ..The aim of this study was to investigate the identity and extension of this maternal Oct4-TN, as much as whether its presence is circumscribed to the egg or maintained beyond fertilisation...
  8. pmc Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes
    Maurizio Zuccotti
    Sezione di Istologia ed Embriologia, Dipartimento di Medicina Sperimentale, Universita degli Studi di Parma, Parma, Italy
    BMC Dev Biol 8:97. 2008
    ....
  9. pmc A hierarchical Naïve Bayes Model for handling sample heterogeneity in classification problems: an application to tissue microarrays
    Francesca Demichelis
    Bionformatics, SRA, ITC irst and Dept of Information and Communication Technology, University of Trento, Trento, Italy
    BMC Bioinformatics 7:514. 2006
    ..The aim of this paper is to provide and validate a classification model taking into consideration the uncertainty associated with measuring replicate samples...
  10. pmc Phenotype forecasting with SNPs data through gene-based Bayesian networks
    Alberto Malovini
    IRCCS Multimedica, via Fantoli 16 15, I 20138 Milano, Italy
    BMC Bioinformatics 10:S7. 2009
    ..In this paper we present a new strategy to achieve this goal by mapping the SNPs related to the same gene to one meta-variable. In order to assign states to the meta-variables we employ an approach based on classification trees...
  11. ncbi request reprint Management of patients with diabetes through information technology: tools for monitoring and control of the patients' metabolic behavior
    Riccardo Bellazzi
    Dipartimento di Informatica e Sistemistica, Universita di Pavia, Italy
    Diabetes Technol Ther 6:567-78. 2004
    ....
  12. pmc Data mining technologies for blood glucose and diabetes management
    Riccardo Bellazzi
    Dipartimento di Informatica e Sistemistica, Universita di Pavia, Pavia, Italy
    J Diabetes Sci Technol 3:603-12. 2009
    ....
  13. ncbi request reprint Predictive data mining in clinical medicine: current issues and guidelines
    Riccardo Bellazzi
    Dipartimento di Informatica e Sistemistica, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Int J Med Inform 77:81-97. 2008
    ....
  14. ncbi request reprint Methods and tools for mining multivariate temporal data in clinical and biomedical applications
    Riccardo Bellazzi
    Dipartimento di Informatica e Sistemistica, University of Pavia, Via Ferrata 1, Pavia, Italy
    Conf Proc IEEE Eng Med Biol Soc 2009:5629-32. 2009
    ..The methods is described and the results obtained on two clinical data sets are shown...
  15. ncbi request reprint Temporal data mining for the quality assessment of hemodialysis services
    Riccardo Bellazzi
    Dipartimento di Informatica e Sistemistica, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Artif Intell Med 34:25-39. 2005
    ....
  16. ncbi request reprint Design, methods, and evaluation directions of a multi-access service for the management of diabetes mellitus patients
    Riccardo Bellazzi
    Dipartimento di Informatica e Sistemistica DIS, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Diabetes Technol Ther 5:621-9. 2003
    ..The M2DM system allows for the implementation of an easy-to-use, user-tailored telemedicine system for diabetes management. The first clinical results are encouraging and seem to substantiate the hypothesis of its clinical effectiveness...
  17. pmc Data analysis and data mining: current issues in biomedical informatics
    R Bellazzi
    University of Pavia, Dipartimento di Informatica e Sistemistica, Via Ferrata 1, 27100 Pavia PV, Italy
    Methods Inf Med 50:536-44. 2011
    ..Biomedical informatics provides a proper interdisciplinary context to integrate data and knowledge when processing available information, with the aim of giving effective decision-making support in clinics and translational research...
  18. ncbi request reprint Information technology solutions to support translational research on inherited cardiomyopathies
    Riccardo Bellazzi
    Dipartimento di Informatica e Sistemistica, Universita di Pavia, Italy
    Stud Health Technol Inform 169:907-11. 2011
    ..The paper describes the design of these tools and the current status of implementation...
  19. doi request reprint Mouse embryonic stem cells irradiated with γ-rays differentiate into cardiomyocytes but with altered contractile properties
    Paola Rebuzzini
    Laboratorio di Biologia dello Sviluppo, Dipartimento di Biologia e Biotecnologie Lazzaro Spallanzani, Universita degli Studi di Pavia, Via Ferrata 9, 27100 Pavia, Italy
    Mutat Res 756:37-45. 2013
    ..Our results indicate that mESCs populations that survive an ionizing irradiation treatment are capable to differentiate into cardiomyocytes, but they have altered contractile properties. ..
  20. ncbi request reprint TimeClust: a clustering tool for gene expression time series
    Paolo Magni
    Dipartimento di Informatica e Sistemistica, Universita degli Studi di Pavia, Via Ferrata 1, Pavia, Italy
    Bioinformatics 24:430-2. 2008
    ..It implements two original algorithms specifically designed for clustering short time series together with hierarchical clustering and self-organizing maps...
  21. pmc R engine cell: integrating R into the i2b2 software infrastructure
    Daniele Segagni
    IRCCS Fondazione S Maugeri, Pavia, Italy
    J Am Med Inform Assoc 18:314-7. 2011
    ..R Engine Cell has been designed to easily support the integration of other R-based statistical analyses into i2b2...
  22. pmc An ICT infrastructure to integrate clinical and molecular data in oncology research
    Daniele Segagni
    IRCCS Fondazione Salvatore Maugeri, Pavia, 27100, Italy
    BMC Bioinformatics 13:S5. 2012
    ..I2b2 has delivered an open source suite based on a data warehouse, which is efficiently interrogated to find sets of interesting patients through a query tool interface...
  23. ncbi request reprint Inferring gene regulatory networks by integrating static and dynamic data
    Fulvia Ferrazzi
    Dipartimento di Informatica e Sistemistica, Universita degli Studi di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Int J Med Inform 76:S462-75. 2007
    ..We exploited data from deletion mutant experiments (static data), gene expression time series (dynamic data) and the knowledge encoded in the Gene Ontology...
  24. pmc Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes
    Giulia Vigone
    Laboratorio di Biologia dello Sviluppo, Dipartimento di Biologia e Biotecnologie Lazzaro Spallanzani, Universita degli Studi di Pavia, Pavia, Italy
    BMC Genomics 14:380. 2013
    ..Here, we isolated CCs from antral mouse oocytes of known developmental incompetence (NSN-CCs) or competence (SN-CCs) and compared their transcriptomes with the aim of identifying distinct marker transcripts...
  25. doi request reprint Knowledge-based bioinformatics for the study of mammalian oocytes
    Francesca Mulas
    Centre for Tissue Engineering, University of Pavia, Via Ferrata 1, Pavia, Italy
    Int J Dev Biol 56:859-66. 2012
    ....
  26. ncbi request reprint CARDIO-i2b2: integrating arrhythmogenic disease data in i2b2
    Daniele Segagni
    IRCCS Fondazione Salvatore Maugeri, Pavia, Italy
    Stud Health Technol Inform 180:1126-8. 2012
    ..The research infrastructure is extended by the development of new plug-ins for the i2b2 web client application able to properly select and export phenotypic data and to perform data analysis...
  27. ncbi request reprint The ONCO-I2b2 project: integrating biobank information and clinical data to support translational research in oncology
    Daniele Segagni
    IRCCS Fondazione S Maugeri, Pavia, Italy
    Stud Health Technol Inform 169:887-91. 2011
    ..The system currently manages more than two thousands patients and will be further implemented and improved in the next two years...
  28. ncbi request reprint Towards knowledge-based gene expression data mining
    Riccardo Bellazzi
    Dipartimento di Informatica e Sistemistica, Universita di Pavia, Via Ferrata 1, I 27100 Pavia, Italy
    J Biomed Inform 40:787-802. 2007
    ..In particular, we discuss recent developments in gene expression-based analysis methods used in association and classification studies, phenotyping and reverse engineering of gene networks...
  29. ncbi request reprint TA-clustering: cluster analysis of gene expression profiles through Temporal Abstractions
    Lucia Sacchi
    Dipartimento di Informatica e Sistemistica, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Int J Med Inform 74:505-17. 2005
    ..We demonstrate the utility of the proposed algorithm on a set of two simulated data sets and on a study of gene expression data from S. cerevisiae...
  30. pmc Inferring cell cycle feedback regulation from gene expression data
    Fulvia Ferrazzi
    Dipartimento di Informatica e Sistemistica, Universita degli Studi di Pavia, Pavia, Italy
    J Biomed Inform 44:565-75. 2011
    ..In conclusion, we provide a novel approach to identify critical genes for the dynamics of biological processes. This may lead to the identification of therapeutic targets in diseases that involve perturbations of these dynamics...
  31. pmc Phenotypic and genotypic data integration and exploration through a web-service architecture
    Angelo Nuzzo
    Department of Computer Engineering and Systems Science, University of Pavia, Via Ferrata 1, Pavia, Italy
    BMC Bioinformatics 10:S5. 2009
    ..This paper describes the use of Information Technology methods and tools to develop a system for the management, inspection and integration of phenotypic and genotypic data...
  32. pmc Temporal data mining for the assessment of the costs related to diabetes mellitus pharmacological treatment
    Stefano Concaro
    University of Pavia, Pavia, Italy
    AMIA Annu Symp Proc 2009:119-23. 2009
    ..Considering the perspective of a Regional Healthcare Agency, this method could be properly exploited to assess the overall standards and quality of care, while lowering costs...
  33. ncbi request reprint Precedence Temporal Networks to represent temporal relationships in gene expression data
    Lucia Sacchi
    Dipartimento di Informatica e Sistemistica, University of Pavia, Via Ferrata n o 1, 27100 Pavia, Italy
    J Biomed Inform 40:761-74. 2007
    ..The extracted networks reflect the capability of the algorithm to clearly reconstruct the timing of the considered gene sets, highlighting different stages in Dictyostelium development and in the cell cycle, respectively...
  34. doi request reprint Comparison of elastographic strain index and thyroid fine-needle aspiration cytology in 631 thyroid nodules
    Flavia Magri
    MD, PhD, Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri Istituto di Ricovero e Cura a Carattere Scientifico, Via S Maugeri 10, 27100 Pavia, Italy
    J Clin Endocrinol Metab 98:4790-7. 2013
    ..However, the accuracy of this technique is hampered by the intra- and interoperator variability, some US features of the nodule, and the coexistence of autoimmune thyroid disease (ATD)...
  35. pmc Stochastic model search with binary outcomes for genome-wide association studies
    Alberto Russu
    Department of Industrial and Information Engineering, University of Pavia, Pavia, Italy
    J Am Med Inform Assoc 19:e13-20. 2012
    ..We introduce a novel Bayesian model search algorithm, Binary Outcome Stochastic Search (BOSS), which addresses the model selection problem when the number of predictors far exceeds the number of binary responses...
  36. ncbi request reprint Insulin minimal model indexes and secretion: proper handling of uncertainty by a Bayesian approach
    Paolo Magni
    Dipartimento di Informatica e Sistemistica, Università degli Studi di Pavia via Ferrata, Pavia, Italy
    Ann Biomed Eng 32:1027-37. 2004
    ....
  37. ncbi request reprint Interest propagation for knowledge extraction and representation
    Francesca Mulas
    Dipartimento di Ingegneria Industriale e dell Informazione, Universita di Pavia, Italy
    Stud Health Technol Inform 186:182-6. 2013
    ..The assessment of the relevance of the retrieved information confirmed a high accuracy of the presented algorithms for both the domains considered...
  38. ncbi request reprint Development and representation of health indicators with thematic maps
    Simona Dalle Carbonare
    Dipartimento di Informatica e Sistemistica, University of Pavia, Italy
    Stud Health Technol Inform 180:220-4. 2012
    ..The implemented tool is currently up-and-running and has been evaluated with a usability questionnaire on a small number of users...
  39. doi request reprint Computer-based genealogy reconstruction in founder populations
    Giuseppe Milani
    Department of Computer Engineering and Systems Science, University of Pavia, Pavia, Italy
    J Biomed Inform 44:997-1003. 2011
    ..The genealogy could be reconstructed from data going back as far as the XVI century. The resulting pedigree includes 75,994 trios, 58.9% of which belonging to a unique big family, reconstructed over 13 generations...
  40. ncbi request reprint Mining administrative and clinical diabetes data with temporal association rules
    Stefano Concaro
    Dipartimento di Informatica e Sistemistica, Universita di Pavia, 27100 Pavia, Italy
    Stud Health Technol Inform 150:574-8. 2009
    ....
  41. ncbi request reprint Telemedicine in the management of young patients with type 1 diabetes mellitus: a follow-up study
    Giuseppe d'Annunzio
    Department of Pediatrics, IRCCS Policlinico San Matteo, Pavia, Italy
    Acta Biomed 74:49-55. 2003
    ..02). In pediatric patients periodical visits are necessary, but T-IDDM enables continuity of care improving access and activities. An index is represented by the high number of messages between the 2 Units, seeming weekly exchange...
  42. ncbi request reprint Inferring gene expression networks via static and dynamic data integration
    Fulvia Ferrazzi
    Dipartimento di Informatica e Sistemistica, Universita degli Studi di Pavia, Italy
    Stud Health Technol Inform 124:119-24. 2006
    ..The proposed approach was able to reconstruct known relationships among genes and to provide meaningful biological results...
  43. ncbi request reprint A stochastic model to assess the variability of blood glucose time series in diabetic patients self-monitoring
    Paolo Magni
    Dipartimento di Informatica e Sistemistica, Universita degli Studi di Pavia, Italy
    IEEE Trans Biomed Eng 53:977-85. 2006
    ..The method here proposed has been validated on two simulated data sets and tested with success in the retrospective analysis of three patients' data sets...
  44. ncbi request reprint Temporal clustering for blood glucose analysis in the ICU: identification of groups of patients with different risk profile
    Lucia Sacchi
    Computer Engineering Systems Science Department, University of Pavia, Pavia, Italy
    Stud Health Technol Inform 160:1150-4. 2010
    ..We show that it is possible to identify two groups based on the initial blood glucose trends, and that the two groups significantly differ in terms of their future BG behaviour...
  45. pmc Hierarchical Naive Bayes for genetic association studies
    Alberto Malovini
    Department of Industrial and Information Engineering, University of Pavia, Pavia, 27100, Italy
    BMC Bioinformatics 13:S6. 2012
    ..Validation shows that our model reaches classification performances superior to those obtained by the standard Naïve Bayes classifier for simulated and real datasets...
  46. ncbi request reprint A dynamic query system for supporting phenotype mining in genetic studies
    Angelo Nuzzo
    Department of Computer Science and Systems, University of Pavia, Pavia, Italy
    Stud Health Technol Inform 129:1275-9. 2007
    ..The system has been applied in a study on genetically isolated individuals, the Val Borbera project...
  47. ncbi request reprint A careflow management system for chronic patients
    Silvia Panzarasa
    Consorzio di Bioingegneria e Informatica Medica, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Stud Health Technol Inform 107:673-7. 2004
    ....
  48. ncbi request reprint Text Mining approaches for automated literature knowledge extraction and representation
    Angelo Nuzzo
    Center for Tissue Engineering University of Pavia, Italy
    Stud Health Technol Inform 160:954-8. 2010
    ..We show that the system i) is able to effectively retrieve medical concepts and genes and ii) plays a relevant role assisting researchers in the formulation and evaluation of novel literature-based hypotheses...
  49. doi request reprint Expression of estrogen and androgen receptors in differentiated thyroid cancer: an additional criterion to assess the patient's risk
    Flavia Magri
    Units of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri IRCCS, University of Pavia, 27100 Pavia, Italy
    Endocr Relat Cancer 19:463-71. 2012
    ..ER and AR expressions may represent an additional criterion in deciding whether to perform radioiodine ablation in these tumors...
  50. pmc Bayesian approaches to reverse engineer cellular systems: a simulation study on nonlinear Gaussian networks
    Fulvia Ferrazzi
    Dipartimento di Informatica e Sistemistica, Universita degli Studi di Pavia, Pavia, Italy
    BMC Bioinformatics 8:S2. 2007
    ..However, DBN approaches that use continuous variables, thus avoiding the information loss associated with discretization, have not yet been extensively assessed, and most of the proposed approaches have dealt with linear Gaussian models...
  51. ncbi request reprint Building a normative decision support system for clinical and operational risk management in hemodialysis
    Chiara Cornalba
    Department of Applied Statistics and Economics L Lenti, University of Pavia, 27100 Pavia, Italy
    IEEE Trans Inf Technol Biomed 12:678-86. 2008
    ..Examples and case studies are also shown. The tool is one of the few examples of normative system explicitly conceived to manage operational and clinical risks in health care environments...
  52. ncbi request reprint A Unified Medical Language System (UMLS) based system for Literature-Based Discovery in medicine
    Matteo Gabetta
    Department of Industrial and Information Engineering, University of Pavia, Italy
    Stud Health Technol Inform 192:412-6. 2013
    ..Validation showed that the system is able to discover many gene-disease associations by using the literature available before their first publication in a scientific article. ..
  53. pmc Transcriptional profiles of mating-responsive genes from testes and male accessory glands of the Mediterranean fruit fly, Ceratitis capitata
    Francesca Scolari
    Department of Biology and Biotechnology, University of Pavia, Pavia, Italy
    PLoS ONE 7:e46812. 2012
    ..Molecular characterization of seminal fluid proteins in the Mediterranean fruit fly, Ceratitis capitata, is limited, although studies suggest that some of these proteins are biologically active...
  54. pmc Forecast model for the evaluation of economic resources employed in the health care of patients with HIV infection
    Paolo Sacchi
    Divisione di Malattie Infettive e Tropicali Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Clinicoecon Outcomes Res 4:117-26. 2012
    ..The aim of the present study is to define a pharmacoeconomic model for the forecast of the costs of a group of chronically treated patients followed over the period 2004-2009...
  55. pmc Localization of Magic-F1 transgene, involved in muscular hypertrophy, during early myogenesis
    Flavio Ronzoni
    Human Anatomy Section, University of Pavia, Via Forlanini 8, 27100 Pavia, Italy
    J Biomed Biotechnol 2011:492075. 2011
    ..These data suggest that Magic-F1 could be responsible of muscular hypertrophy, cooperating with Pax3 signal pathway in skeletal muscle precursor cells...
  56. pmc Bringing the artificial pancreas home: telemedicine aspects
    Giordano Lanzola
    Dipartimento di Informatica e Sistemistica, Universita di Pavia, Pavia, Italy
    J Diabetes Sci Technol 5:1381-6. 2011
    ....
  57. pmc The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure
    Sara Raimondi
    Department of Biochemistry, University of Pavia, via Taramelli 3b, 27100 Pavia, Italy
    BMC Evol Biol 11:159. 2011
    ..Therefore, based on the peculiar differences of the two tryptophans, we have analysed the evolution of β2-microglobulin with respect to these residues...
  58. ncbi request reprint Analysing Italian voluntary abortion data using a Bayesian approach to the time series decomposition
    Paolo Magni
    Dipartimento di Informatica e Sistemistica, Universita degli Studi di Pavia, Via Ferrata 1, Pavia, Italy
    Stat Med 23:105-23. 2004
    ..Finally, at the local level this analysis allows us to find similarities/differences between different areas in trends and/or in seasonal preferences...
  59. pmc Prediction of peptide reactivity with human IVIg through a knowledge-based approach
    Nicola Barbarini
    Laboratory of Biomedical Informatics Mario Stefanelli, Department of Computer Engineering and Systems Science, University of Pavia, Pavia, Italy
    PLoS ONE 6:e23616. 2011
    ..The paper describes the developed model and its results in terms of reactivity prediction, and highlights some open issues concerning the propensity of a peptide to react with human antibodies...
  60. ncbi request reprint Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome
    Marta Tomas
    Molecular Cardiology Laboratories, IRCCS Salvatore Maugeri Foundation, Pavia, Italy
    J Am Coll Cardiol 55:2745-52. 2010
    ..We investigated the role of nitric oxide 1 adaptor protein (NOS1AP) as a genetic modifier of long QT syndrome (LQTS)...
  61. doi request reprint The differentiation of cardiomyocytes from mouse embryonic stem cells is altered by dioxin
    Tui Neri
    Laboratorio di Biologia dello Sviluppo, Dipartimento di Biologia Animale, Universita degli Studi di Pavia, Via Ferrata 9, 27100 Pavia, Italy
    Toxicol Lett 202:226-36. 2011
    ..This study provides novel evidences that TCDD impairs cardiomyocyte differentiation. Sarcomeres and mitochondria could be a target for dioxin toxicity, their disruption representing a possible mechanism developing cardiac injury...
  62. ncbi request reprint A methodology for the extraction of quantitative risk indexes from medical injuries compensation claims
    Simona Dalle Carbonare
    Dipartimento di Informatica e Sistemistica, University of Pavia, 27100 Pavia, Italy
    Stud Health Technol Inform 150:595-9. 2009
    ..The approach, adapted from operational and financial risk management, proved to be useful to understand the risk structure in terms of frequency, severity, expected and unexpected loss related to adverse events...
  63. doi request reprint Network-based target ranking for polypharmacological therapies
    Francesca Vitali
    Dipartimento di Ingegneria Industriale e dell Informazione, University of Pavia, Pavia, Italy Electronic address
    J Biomed Inform 46:876-81. 2013
    ..We illustrate the potential of the method through a study on Type 2 Diabetes Mellitus. The results highlight its ability to retrieve novel target candidates, which role is also confirmed by the analysis of the related literature. ..
  64. doi request reprint Quantitative expression of the mutated lamin A/C gene in patients with cardiolaminopathy
    Nupoor Narula
    Centre for Inherited Cardiovascular Diseases, Foundation IRCCS Policlinico San Matteo, University of Pavia, Piazzale Golgi 19, Pavia, Italy
    J Am Coll Cardiol 60:1916-20. 2012
    ..The authors sought to investigate the gene and protein expression in Lamin A/C (LMNA)-mutated dilated cardiolaminopathy (DCM) patients (DCM(LMNAMut)) versus LMNA-wild-type DCM (DCM(LMNAWT)), and normal controls (CTRL(LMNAWT))...
  65. pmc Development of a novel bioinformatics tool for in silico validation of protein interactions
    Nicola Barbarini
    Laboratory of BioMedical Informatics, Department of Computer Science and Systems, University of Pavia, Pavia, Italy
    J Biomed Biotechnol 2010:670125. 2010
    ..In conclusion, the proposed method can be conveniently exploited to select the proteins to be experimentally investigated within a set of potential interactors...
  66. pmc Different molecular mechanisms causing 9p21 deletions in acute lymphoblastic leukemia of childhood
    Francesca Novara
    Biologia Generale e Genetica Medica, Universita degli Studi di Pavia, Via Forlanini, 14, 27100 Pavia, Italy
    Hum Genet 126:511-20. 2009
    ..Among the six cases with heterozygous 9p deletions, we found that the remaining CDKN2A and CDKN2B alleles were hypermethylated at CpG islands...
  67. doi request reprint Mining health care administrative data with temporal association rules on hybrid events
    S Concaro
    Dipartimento di Informatica e Sistemistica, Universita di Pavia, Pavia, Italy
    Methods Inf Med 50:166-79. 2011
    ..In this paper we present an algorithm for the extraction of temporal association rules (TARs) on sequences of hybrid events and its application on health care administrative databases...
  68. ncbi request reprint Reduced sampling schedule for the glucose minimal model: importance of Bayesian estimation
    Paolo Magni
    Dipartimento di Informatica e Sistemica, Universita degli Studi di Padova, I 35131 Padua, Italy
    Am J Physiol Endocrinol Metab 290:E177-E184. 2006
    ..g., excluding negative values) are obtained. They can be crucial for a subsequent use of the estimated MM parameters, such as in classification, clustering, regression, or risk analysis...
  69. ncbi request reprint Case-based retrieval to support the treatment of end stage renal failure patients
    Stefania Montani
    Dipartimento di Informatica, Universita del Piemonte Orientale, Via Bellini 25 G, 15100 Alessandria, Italy
    Artif Intell Med 37:31-42. 2006
    ..In the present paper, we describe an application of case-based retrieval to the domain of end stage renal failure patients, treated with hemodialysis...
  70. ncbi request reprint Minimal model S(I)=0 problem in NIDDM subjects: nonzero Bayesian estimates with credible confidence intervals
    Gianluigi Pillonetto
    Dipartimento di Elettronica e Informatica, Universita degli Studi di Padova, 35131 Padova, Italy
    Am J Physiol Endocrinol Metab 282:E564-73. 2002
    ..This Bayesian approach should prove useful in reanalyzing large databases of epidemiological studies...
  71. ncbi request reprint Integrating model-based decision support in a multi-modal reasoning system for managing type 1 diabetic patients
    Stefania Montani
    DiSTA, Universita del Piemonte Orientale A Avogadro, Alessandria, Italy
    Artif Intell Med 29:131-51. 2003
    ..The system has been tested both on simulated and on real patients' data...
  72. ncbi request reprint Knowledge-based data analysis and interpretation
    Blaz Zupan
    Artif Intell Med 37:163-5. 2006
  73. ncbi request reprint Temporal abstraction for feature extraction: a comparative case study in prediction from intensive care monitoring data
    Marion Verduijn
    Department of Medical Informatics, Academic Medical Center, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Artif Intell Med 41:1-12. 2007
    ..The two temporal abstraction procedures compared in this case study differ in this respect...
  74. ncbi request reprint Supporting decisions in medical applications: the knowledge management perspective
    Stefania Montani
    Dipartimento di Informatica, Universita del Piemonte Orientale A Avogadro, Spalto Marengo 33, I 15100, Alessandria, Italy
    Int J Med Inform 68:79-90. 2002
    ..Our methodology has been successfully tested on an application in the field of diabetic patients management...