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Genomes and Genes | Daniela BassoSummaryAffiliation: University Hospital Country: Italy Publications
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Publications
Pancreatic tumors and immature immunosuppressive myeloid cells in blood and spleen: role of inhibitory co-stimulatory molecules PDL1 and CTLA4. An in vivo and in vitro studyDaniela Basso
Department of Medicine, University of Padova, Padova, Italy
PLoS ONE 8:e54824. 2013....
Pathogenesis of Helicobacter pylori infectionDaniela Basso
Department of Laboratory Medicine, University Hospital of Padova, Via Giustiniani 2, Padua, Italy
Helicobacter 15:14-20. 2010..Among those are studies on the genetic variation of genes encoding outer membrane proteins and the mimicry of host antigens, factors that alter host-cell metabolism and factors that modulate the host's immune response...
Clarithromycin resistance, tumor necrosis factor alpha gene polymorphism and mucosal inflammation affect H. pylori eradication successCarlo Federico Zambon
Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
J Gastrointest Surg 11:1506-14; discussion 1514. 2007....- Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphismsDaniela Basso
Department of Laboratory Medicine, University of Padova, Padova, Italy
Gastroenterology 135:91-9. 2008..We assessed the association of new and established cagA and vacA polymorphisms with disease... - Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcomeCarlo F Zambon
Department of Medical and Surgical Sciences, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
Cytokine 29:141-52. 2005..In conclusion, among host genetic factors contributing to H. pylori disease outcome, IFN-G +874 AA genotype favors cagA positive infections, TNF-A -857 TT duodenal ulcer while IL-10 -819 TT intestinal metaplasia and NCGC... - Oxidative DNA damage in gastric cancer: CagA status and OGG1 gene polymorphismFabio Farinati
Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Universita di Padova, Padova, Italy
Int J Cancer 123:51-5. 2008..OGG1 1245C-->G polymorphism was common in both GC and IMA, but very rare in controls, and correlated more closely with 8-OHdG levels than do H. pylori infection or cagA status... - Antibodies against synthetic deamidated gliadin peptides for celiac disease diagnosis and follow-up in childrenDaniela Basso
Department of Laboratory Medicine, University of Padova, Italy
Clin Chem 55:150-7. 2009..AGA IgA II and AGA IgG II have recently been suggested as reliable tools for celiac disease (CD) diagnosis. We compared their utility for diagnosis and monitoring CD in children with that of tTG IgA, an established CD marker... - Mitochondrial DNA D-loop in pancreatic cancer: somatic mutations are epiphenomena while the germline 16519 T variant worsens metabolism and outcomeFilippo Navaglia
Department of Laboratory Medicine, University of Padova, Italy
Am J Clin Pathol 126:593-601. 2006.... - IL-4 -588C>T polymorphism and IL-4 receptor alpha [Ex5+14A>G; Ex11+828A>G] haplotype concur in selecting H. pylori cagA subtype infectionsCarlo Federico Zambon
Department of Medical and Surgical Sciences, University of Padova, Italy
Clin Chim Acta 389:139-45. 2008..pylori virulence genes or H. pylori associated diseases... - Non-invasive diagnosis of Helicobacter pylori infection: simplified 13C-urea breath test, stool antigen testing, or DNA PCR in human feces in a clinical laboratory setting?Carlo Federico Zambon
Department of Medical and Surgical Sciences, University of Padova, Italy
Clin Biochem 37:261-7. 2004..2) To ascertain whether a simplified UBT (breath collection time = 10 min) is as reliable as the standard assay (30 min)... - Suicide gene therapy with the yeast fusion gene cytosine deaminase/uracil phosphoribosyltransferase is not enough for pancreatic cancerPaola Fogar
Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
Pancreas 35:224-31. 2007..We ascertained whether gene therapy with FCY1-FUR1 is effective in killing pancreatic cancer cells after 5-fluorocytosine (5-FC) treatment... - Fecal lactoferrin and calprotectin after ileocolonic resection for Crohn's diseaseMarco Scarpa
Clinica Chirurgica I, Dipartimento di Scienze Chirurgiche e Gastroenterologiche, University of Padova, Padova, Italy
Dis Colon Rectum 50:861-9. 2007..This study was designed to assess the role of fecal lactoferrin and calprotectin as markers of intestinal inflammation in patients with Crohn's disease who have undergone ileocolonic resection... - Molecular refinement of clinical staging in hepatocellular carcinoma patients evaluated for potentially curative therapiesAlessandro Vitale
Unità di Chirurgia Epatobiliare e Trapianto Epatico, Dipartimento di Chirurgia Generale e Trapianti d Organo, Universita di Padova, Padova, Italy
PLoS ONE 6:e23093. 2011..VEGF and AFP mRNA determinations in the blood are promising prognostic factors for patients with HCC. This study explores their potential prognostic synergy in a cohort of HCC patients evaluated for potentially curative therapies... - Analogs of vitamin E epitomized by alpha-tocopheryl succinate for pancreatic cancer treatment: in vitro results induce caution for in vivo applicationsEliana Greco
Department of Laboratory Medicine, University of Padova, Padova, Italy
Pancreas 39:662-8. 2010.... - Altered intracellular calcium fluxes in pancreatic cancer induced diabetes mellitus: Relevance of the S100A8 N-terminal peptide (NT-S100A8)Daniela Basso
Department of Laboratory Medicine, University of Padua, Padua, Italy
J Cell Physiol 226:456-68. 2011.... - Pancreatic cancer biomarkers discovery by surface-enhanced laser desorption and ionization time-of-flight mass spectrometryFilippo Navaglia
Department of Laboratory Medicine, University of Padova, Padova, Italy
Clin Chem Lab Med 47:713-23. 2009..The aim of the present study was to explore the application of SELDI proteomic patterns in serum for distinguishing between cases of pancreatic cancer, chronic pancreatitis, type 2 diabetes mellitus and healthy controls... - Maldi-TOF analysis of portal sera of pancreatic cancer patients: identification of diabetogenic and antidiabetogenic peptidesAnna Valerio
Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
Clin Chim Acta 343:119-27. 2004..CONCLUSIONS: Unlike liver GAPDH, NO appears to be involved in PC associated DM. In portal sera, the absence, rather than the presence, of specific fragments, appears to be correlated with the development of DM... - DNA repair pathways and mitochondrial DNA mutations in gastrointestinal carcinogenesisDaniela Basso
Department of Laboratory Medicine, University Hospital of Padova, Via Giustiniani 2, 35128 Padova, Italy
Clin Chim Acta 381:50-5. 2007.... - Pancreatic cancer-derived S-100A8 N-terminal peptide: a diabetes cause?Daniela Basso
Department of Laboratory Medicine, University of Padua, Via Giustiniani 2, 35128 Padova, Italy
Clin Chim Acta 372:120-8. 2006..Our aim was to identify the pancreatic cancer diabetogenic peptide... - Decreased total lymphocyte counts in pancreatic cancer: an index of adverse outcomePaola Fogar
Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
Pancreas 32:22-8. 2006.... - Pancreatic cancer-associated diabetes mellitus: an open field for proteomic applicationsDaniela Basso
Department of Laboratory Medicine, University of Padova, Via Giustiniani 2, Padova 35128, Italy
Clin Chim Acta 357:184-9. 2005..CONCLUSIONS: We identified a tumor-derived peptide of 14 amino acids sharing a 100% homology with an S-100 calcium binding protein, which is probably the pancreatic cancer-associated diabetogenic factor... - Effectiveness of the combined evaluation of KLK3 genetics and free-to-total prostate specific antigen ratio for prostate cancer diagnosisCarlo Federico Zambon
Department of Laboratory Medicine, University of Padova, Padova, Italy
J Urol 188:1124-30. 2012..We ascertained whether the knowledge of KLK3 genetics would enhance prostate specific antigen diagnostic performance in patients with clinical suspicion of prostate cancer... - Usefulness of MALDI-TOF/MS Identification of Low-MW Fragments in Sera for the Differential Diagnosis of Pancreatic CancerAndrea Padoan
From the Department of Laboratory Medicine, University of Padova CNR ISTM Departments of Surgical Oncological and Gastroenterological Sciences DiSCOG and Medicine DIMED, University of Padova, Padova First Division of General Surgery, University of Verona, Verona General Surgery, Pieve di Coriano Hospital, Mantova and SIPRES, Gruppo Pavanello, Padova, Italy
Pancreas 42:622-32. 2013..To identify new biomarkers of pancreatic cancer (PaCa), we performed MALDI-TOF/MS analysis of sera from 22 controls, 51 PaCa, 37 chronic pancreatitis, 24 type II diabetes mellitus (DM), 29 gastric cancer (GC), and 24 chronic gastritis (CG)... - Retrovirus-mediated herpes simplex virus thymidine kinase gene transfer in pancreatic cancer cell lines: an incomplete antitumor effectEliana Greco
Department of Laboratory Medicine, University of Padova, Padova, Italy
Pancreas 25:e21-9. 2002..CONCLUSION: Gene therapy with HSV-TK for pancreatic cancer seems effective in only a limited number of tumor-derived cell lines, and this limits its application in vivo... - Helicobacter pylori infection in children and adults: a single pathogen but a different pathologyNicoletta Gallo
Department of Laboratory Medicine, University of Padova, Italy
Helicobacter 8:21-8. 2003..The most virulent cagA positive H. pylori colonizes not only the gastric, but also the duodenal mucosa, which can be directly damaged by the bacteria itself or by its products... - New screening tests enrich anti-transglutaminase results and support a highly sensitive two-test based strategy for celiac disease diagnosisDaniela Basso
Department of Laboratory Medicine, University of Padova, Padova, Italy
Clin Chim Acta 412:1662-7. 2011..We compared the diagnostic accuracy of three new tests proposed for CD screening with that of the well established IgA tTG, and ascertained whether any combination of these tools might enhance accuracy in diagnosing CD... - Immunotherapy for gastric premalignant lesions and cancerValerio Zorzetto
Department of Surgical, Oncological and Gastroenterological Sciences, Policlinico Universitario, Via Giustiniani 2, 35128 Padova, Italy
Immunotherapy 4:587-99. 2012..No study on immunotherapy of carcinoids is available but, in our experience, the administration of an antigastrin 17 vaccine induced carcinoid regression in two out of three patients treated... - VKORC1, CYP2C9 and CYP4F2 genetic-based algorithm for warfarin dosing: an Italian retrospective studyCarlo Federico Zambon
Department of Laboratory Medicine, University Hospital of Padua, 35128 Padua, Italy
Pharmacogenomics 12:15-25. 2011..A total of 371 patients under stable warfarin therapy were retrospectively selected to develop a pharmacogenetic algorithm to identify the individual maintenance dose... - Decreased expression and promoter methylation of the menin tumor suppressor in pancreatic ductal adenocarcinomaIlaria Cavallari
Department of Oncology and Surgical Sciences, University of Padova, Via Gattamelata 64, Padova 35128, Italy
Genes Chromosomes Cancer 48:383-96. 2009..These findings represent the first evidence that the MEN1 gene is a target of mutation and methylation in PDAC and that menin influences the cell cycle profile of duct cells... - Quantitative PSA mRNA determination in blood: a biochemical tool for scoring localized prostate cancerCarlo-Federico Zambon
Department of Medical and Surgical Sciences, University of Padova, Padua, Italy
Clin Biochem 39:333-8. 2006..CONCLUSIONS: tPSA and f/t PSA are the best available tools for discriminating between localized PC and BPH. The quantitative assessment of PSA mRNA in blood might be helpful in the biochemical grading of prostate cancer... - Pancreatic cancer alters human CD4+ T lymphocyte function: a piece in the immune evasion puzzlePaola Fogar
Department of Laboratory Medicine, University of Padova, Padova, Italy
Pancreas 40:1131-7. 2011.... - Celiac disease in North Italian patients with autoimmune thyroid diseasesAglaura Cinzia Spadaccino
Division of Endocrinology, Department of Medical and Surgical Sciences, University of Padova Medical School, Padova, Italy
Autoimmunity 41:116-21. 2008..An IgA deficiency is the most frequent immunodeficiency in humans and, in general, high frequency of this disorder was demonstrated in those with autoimmune diseases... - H. pylori infection: bacterial virulence factors and cytokine gene polymorphisms as determinants of infection outcomeDaniela Basso
Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy
Crit Rev Clin Lab Sci 41:313-37. 2004..pylori infection. This review focuses on the role of H. pylori virulence genes and on host cytokines' genes polymorphisms in determining clinical outcome to H. pylori infection... - A new indirect chemiluminescent immunoassay to measure anti-tissue transglutaminase antibodiesDaniela Basso
Department of Laboratory Medicine, University of Padova, Padova, Italy
J Pediatr Gastroenterol Nutr 43:613-8. 2006..The anti-tTG test correlates with the degree of mucosal destruction and is suitable for verifying patient compliance to dietary treatment... - Gastric type I carcinoid: a pilot study with human G17DT immunogen vaccinationChiara Tieppo
Department of Surgical and Gastroenterological Sciences, Policlinico Universitario, Via Giustiniani 2, Padua, Italy
Cancer Immunol Immunother 60:1057-60. 2011..The approach to treatment, either endoscopic, medical or surgical, is not well defined, particularly in multifocal tumours or carcinoids with rapid growth/frequent recurrence... - Clinical significance of alpha-fetoprotein mRNA in blood of patients with hepatocellular carcinomaUmberto Cillo
Clinica Chirurgica I, Department of Surgical and Gastroenterological Sciences, University of Padua, School of Medicine, Via Giustiniani 2, Policlinico III Piano, 35128 Padova, Italy
Clin Chim Acta 347:129-38. 2004.... - Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphismsCarlo-Federico Zambon
Departments of Medical and Surgical Sciences, Laboratory Medicine, Oncological and Surgical Sciences, Gastroenterology, and Pathology, University of Padova, Padova, Italy
Gastroenterology 126:382-4. 2004 - Non-invasive assessment of chronic liver and gastric diseasesMario Plebani
Department of Laboratory Medicine, University Hospital of Padova, Italy
Clin Chim Acta 381:39-49. 2007..In these patients, precise definition of the hepatic fibrosis stage is the most important parameter to assess the risk of disease progression and to decide for an immediate and appropriate antiviral therapy... - Enzymes in feces: useful markers of chronic inflammatory bowel diseaseImerio Angriman
Clinica Chirurgica I, Dipartimento di Scienze Chirurgiche e Gastroenterologiche, University of Padova, Italy
Clin Chim Acta 381:63-8. 2007..Ulcerative colitis and Crohn's disease are characterized by a chronic intestinal inflammation. Since the precise etiology is still unknown, current therapies are aimed at reducing or eliminating inflammation... - Mass spectrometry measurement of plasma hepcidin for the prediction of iron overloadAnnarosa Floreani
Department of Surgical and Gastroenterological Sciences, University of Padova, Padova, Italy
Clin Chem Lab Med 49:197-206. 2011..The aims of the study were 1) to assess the performance of this method in different conditions of iron metabolism disorders; 2) to assess the diagnostic validity of non-invasive serum biomarkers in the identification of iron overload... - Putative pancreatic cancer-associated diabetogenic factor: 2030 MW peptideDaniela Basso
Department of Laboratory Medicine, University of Padova, Italy
Pancreas 24:8-14. 2002..Only the peptide at m/z 2030 was found to be associated with the presence of diabetes. CONCLUSION: A peptide at m/z 2030 may be a putative pancreatic cancer-associated diabetogenic factor... - Efficacy of zinc supplementation in preventing acute hepatitis in Long-Evans Cinnamon ratsValentina Medici
Section of Gastroenterology, Department of Surgical and Gastroenterological Sciences, University of Padova, Italy
Liver Int 25:888-95. 2005..8-hydroxy-2'-deoxyguanosine amounts were significantly lower in untreated rats. CONCLUSIONS: Zn acetate prevents acute hepatitis, by increasing tissue MT concentrations, reducing Cu absorption and interfering with Fe metabolism...