Fulvio Basolo

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi request reprint Characterization of thyroglobulin epitopes in patients with autoimmune and non-autoimmune thyroid diseases using recombinant human monoclonal thyroglobulin autoantibodies
    Francesco Latrofa
    Department of Endocrinology, University Hospital of Pisa, Via Cisanello 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 93:591-6. 2008
  2. pmc Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma
    Fulvio Basolo
    Dipartimento di Oncologia, Universita degli Studi di Pisa, Pisa Fondazione Senatore Pascale, Naples, Italy
    Am J Pathol 160:247-54. 2002
  3. pmc The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
    Rosa Marina Melillo
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, Naples, Italy
    J Clin Invest 115:1068-81. 2005
  4. ncbi request reprint Biological role and potential therapeutic targeting of the chemokine receptor CXCR4 in undifferentiated thyroid cancer
    Valentina De Falco
    Dipartimento di Biologia e Patologia Cellulare e Molecolare c o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, Naples, Italy
    Cancer Res 67:11821-9. 2007
  5. ncbi request reprint A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma
    Giuliana Salvatore
    Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Universita Parthenope, Naples, Italy
    Cancer Res 67:10148-58. 2007
  6. pmc The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation
    Maria Domenica Castellone
    Istituto di Endocrinologia ed Oncologia Sperimentale G Salvatore, Consiglio Nazionale delle Ricerche, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita Federico II, Naples, Italy
    Cancer Res 69:1867-76. 2009
  7. ncbi request reprint Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells
    Maria Domenica Castellone
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II c o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Naples, Italy
    Oncogene 23:2188-96. 2004
  8. ncbi request reprint Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement
    Fulvio Basolo
    Dipartimento di Oncologia, Universita degli Studi di Pisa, Pisa, Italy
    Int J Cancer 97:608-14. 2002
  9. ncbi request reprint RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:4725-9. 2007
  10. ncbi request reprint Intrathyroidal differentiated thyroid carcinoma: tumor size-based surgical concepts
    Paolo Miccoli
    Department of Surgery, University of Pisa, Via Roma 67, 56100, Pisa, Italy
    World J Surg 31:888-94. 2007

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Characterization of thyroglobulin epitopes in patients with autoimmune and non-autoimmune thyroid diseases using recombinant human monoclonal thyroglobulin autoantibodies
    Francesco Latrofa
    Department of Endocrinology, University Hospital of Pisa, Via Cisanello 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 93:591-6. 2008
    ....
  2. pmc Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma
    Fulvio Basolo
    Dipartimento di Oncologia, Universita degli Studi di Pisa, Pisa Fondazione Senatore Pascale, Naples, Italy
    Am J Pathol 160:247-54. 2002
    ..In conclusion, we postulate that the correlation between the RET/PTC rearrangement type and the aggressiveness of human PTC is related to the efficiency with which the oncogene subtype delivers mitogenic signals to thyroid cells...
  3. pmc The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
    Rosa Marina Melillo
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, Naples, Italy
    J Clin Invest 115:1068-81. 2005
    ..Thus, motile and mitogenic properties are intrinsic to transformed thyroid cells and are governed by an epistatic oncogenic signaling cascade...
  4. ncbi request reprint Biological role and potential therapeutic targeting of the chemokine receptor CXCR4 in undifferentiated thyroid cancer
    Valentina De Falco
    Dipartimento di Biologia e Patologia Cellulare e Molecolare c o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, Naples, Italy
    Cancer Res 67:11821-9. 2007
    ..Moreover, AMD3100 effectively reduced tumor growth in nude mice inoculated with different ATC cells. Thus, we suggest that CXCR4 targeting is a novel potential strategy in the treatment of human ATC...
  5. ncbi request reprint A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma
    Giuliana Salvatore
    Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Universita Parthenope, Naples, Italy
    Cancer Res 67:10148-58. 2007
    ..Thus, thyroid cell anaplastic transformation is accompanied by the overexpression of a cell proliferation/genetic instability-related gene cluster that includes PLK1 kinase, which is a potential molecular target for ATC treatment...
  6. pmc The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation
    Maria Domenica Castellone
    Istituto di Endocrinologia ed Oncologia Sperimentale G Salvatore, Consiglio Nazionale delle Ricerche, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita Federico II, Naples, Italy
    Cancer Res 69:1867-76. 2009
    ..Thus, multiple signaling events downstream from RET/PTC converge on beta-catenin to stimulate cell proliferation...
  7. ncbi request reprint Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells
    Maria Domenica Castellone
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II c o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Naples, Italy
    Oncogene 23:2188-96. 2004
    ..Thus, RET/PTC signalling triggers an autocrine loop involving OPN and CD44 that sustains proliferation and invasion of transfomed PC Cl 3 thyrocytes...
  8. ncbi request reprint Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement
    Fulvio Basolo
    Dipartimento di Oncologia, Universita degli Studi di Pisa, Pisa, Italy
    Int J Cancer 97:608-14. 2002
    ..Moreover, FB-2 cells produced high levels of interleukin (IL)-6 and IL-8...
  9. ncbi request reprint RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:4725-9. 2007
    ....
  10. ncbi request reprint Intrathyroidal differentiated thyroid carcinoma: tumor size-based surgical concepts
    Paolo Miccoli
    Department of Surgery, University of Pisa, Via Roma 67, 56100, Pisa, Italy
    World J Surg 31:888-94. 2007
    ..The aim of this study was to analyze the pathologic and clinical aspects of a retrospective series of DTCs in an attempt to determine whether these features might prove useful for limiting the surgical strategy in selected cases...
  11. ncbi request reprint Neoadjuvant chemotherapy for stage III and IVA thymomas: a single-institution experience with a long follow-up
    Marco Lucchi
    Division of Thoracic Surgery, Cardiac and Thoracic Departmen, University of Pisa, Pisa, Italy
    J Thorac Oncol 1:308-13. 2006
    ..In this article, we review our long-term experience of neoadjuvant chemotherapy of advanced stage (III-IVA) thymomas...
  12. doi request reprint Dysregulation of secretion of CXC alpha-chemokine CXCL10 in papillary thyroid cancer: modulation by peroxisome proliferator-activated receptor-gamma agonists
    Alessandro Antonelli
    Department of Internal Medicine, School of Medicine, University of Pisa, Pisa, Italy
    Endocr Relat Cancer 16:1299-311. 2009
    ..Moreover, TZDs inhibited CXCL10 secretion in TFC and stimulated it in PTCs. The effect of TZDs on CXCL10 was unrelated to the significant antiproliferative effect in PTCs...
  13. ncbi request reprint Expression of endothelin 1 and its angiogenic role in meningiomas
    Laura Boldrini
    Department of Surgery, University of Pisa, Via Roma 57, 56100 Pisa, Italy
    Virchows Arch 449:546-53. 2006
    ..The association of ET-1 and meningioma represents a potential area for therapeutic intervention with selective ET inhibitors. Additional clinical studies will be needed before inhibitors can be incorporated in clinical practice...
  14. doi request reprint Surgical treatment of pleural recurrence from thymoma
    Marco Lucchi
    Division of Thoracic Surgery, Cardiac and Thoracic Department, University of Pisa, Via Paradisa 2, Pisa 56124, Italy
    Eur J Cardiothorac Surg 33:707-11. 2008
    ..Our aim was to review the literature laying the stress on the incidence, diagnosis, treatment options and prognosis of this highly selected group of patients with pleural recurrence from thymoma...
  15. ncbi request reprint Treatment with drugs able to reduce iodine efflux significantly increases the intracellular retention time in thyroid cancer cells stably transfected with sodium iodide symporter complementary deoxyribonucleic acid
    Rossella Elisei
    Department of Endocrinology and Metabolism, Via Paradisa 2, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 91:2389-95. 2006
    ..One of the major limits of gene therapy with sodium iodide symporter (NIS), which enables cells to be subjected to radioiodine therapy, is that NIS-transfected cells rapidly release the intracellular iodine...
  16. pmc Evaluation of formalin-fixed paraffin-embedded tissues in the proteomic analysis of parathyroid glands
    Elena Donadio
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Bonnanno 6, Pisa, 56126, Italy
    Proteome Sci 9:29. 2011
    ..abstract:..
  17. ncbi request reprint Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 93:682-7. 2008
    ..The aim of this study was to verify the prognostic value of somatic RET mutations in a large series of MTCs with a long follow up...
  18. doi request reprint Correlation between the BRAF V600E mutation and tumor invasiveness in papillary thyroid carcinomas smaller than 20 millimeters: analysis of 1060 cases
    Fulvio Basolo
    Department of Surgery, Division of Pathology, Via Roma, 57, 56126 Pisa, Italy
    J Clin Endocrinol Metab 95:4197-205. 2010
    ....
  19. doi request reprint Are the clinical and pathological features of differentiated thyroid carcinoma really changed over the last 35 years? Study on 4187 patients from a single Italian institution to answer this question
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 95:1516-27. 2010
    ..In the last decades, a marked increased prevalence of differentiated thyroid cancer (DTC) has been observed worldwide. The aim of this study was to evaluate the changing features of DTC referred to our institution between 1969 and 2004...
  20. ncbi request reprint Evaluation of the sensitivity to chemotherapeutics or thiazolidinediones of primary anaplastic thyroid cancer cells obtained by fine-needle aspiration
    Alessandro Antonelli
    Department of Internal Medicine, School of Medicine, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy
    Eur J Endocrinol 159:283-91. 2008
    ..The possibility to obtain ANA from fine-needle aspiration (FNA-ANA) and to test their sensitivity to different drugs could increase the effectiveness of treatments and avoid unnecessary surgical procedures...
  21. doi request reprint BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 93:3943-9. 2008
    ..In this study we verified the prognostic value of the BRAF(V600E) mutation in PTC patients with a long-term follow-up...
  22. doi request reprint Thiazolidinediones and antiblastics in primary human anaplastic thyroid cancer cells
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, I 56100, Pisa, Italy
    Clin Endocrinol (Oxf) 70:946-53. 2009
    ..No study has evaluated the antiproliferative effects of thiazolidinediones and antiblastics in 'primary cultured human anaplastic thyroid cancer cells'...
  23. doi request reprint Association of thymoma and myasthenia gravis: oncological and neurological results of the surgical treatment
    Marco Lucchi
    Cardiac and Thoracic Department, Division of Thoracic Surgery, University of Pisa, Pisa, Italy
    Eur J Cardiothorac Surg 35:812-6; discussion 816. 2009
    ..Both diseases are treated by surgery. The aims of this study were to analyze the clinical features of these patients and the oncological and neurological outcomes after thymectomy...
  24. doi request reprint Management of pleural recurrence after curative resection of thymoma
    Marco Lucchi
    Division of Thoracic Surgery, Cardiac and Thoracic Department, University of Pisa, Pisa, Italy
    J Thorac Cardiovasc Surg 137:1185-9. 2009
    ..Unfortunately, there is no standard treatment for pleural recurrence. This article describes our overall experience with the surgical treatment of pleural implants in patients who previously underwent resection of a thymoma...
  25. ncbi request reprint Advanced stage thymomas and thymic carcinomas: results of multimodality treatments
    Marco Lucchi
    Division of Thoracic Surgery, Cardiac and Thoracic Department, University of Pisa, Pisa, Italy
    Ann Thorac Surg 79:1840-4. 2005
    ..With the aim of evaluating the results of multidisciplinary approaches, we reviewed our experience in multimodality treatment of advanced stage (III and IVA) thymic tumors...
  26. ncbi request reprint Identification of a novel point mutation in the RET gene (Ala883Thr), which is associated with medullary thyroid carcinoma phenotype only in homozygous condition
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:5823-7. 2004
    ..The analysis of several RET polymorphisms also confirmed the presence of two mutated alleles in MTC affected patients and both mutated and wild-type allele in heterozygous subjects...
  27. ncbi request reprint All-trans-retinoic acid treatment inhibits the growth of retinoic acid receptor beta messenger ribonucleic acid expressing thyroid cancer cell lines but does not reinduce the expression of thyroid-specific genes
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Clin Endocrinol Metab 90:2403-11. 2005
    ..The finding of a basal and RA-induced RARbeta mRNA expression only in cell lines responding to all-trans-RA suggests that the growth inhibition might be mediated by RARbeta...
  28. ncbi request reprint Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: experience in 10,864 patients with nodular thyroid disorders
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:163-8. 2004
    ..On this basis, routine measurement of basal serum CT levels should be considered an integral part of the diagnostic evaluation of thyroid nodules...
  29. ncbi request reprint Plasma chromogranin A in incidental non-functioning, benign, solid adrenocortical tumors
    Giampaolo Bernini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Eur J Endocrinol 151:215-22. 2004
    ..In addition, to investigate whether high CgA levels imply a neuroendocrine differentiation of the adrenocortical adenomas and, therefore, represent a humoral marker of malignant transformation of these tumors...
  30. ncbi request reprint Prevalence of cancer in follicular thyroid nodules: is there still a role for intraoperative frozen section analysis?
    Fabio Monzani
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Thyroid 13:389-94. 2003
    ..Protocols aimed at a better cytologic identification of follicular variants of papillary cancer should be considered...
  31. doi request reprint A proteomic approach to study parathyroid glands
    Laura Giusti
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, Via, Bonanno 6, 56126 Pisa, Italy
    Mol Biosyst 7:687-99. 2011
    ..The functional role of these proteins in the network of intracellular pathways is discussed...
  32. ncbi request reprint Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas
    Maria D Castellone
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, 80131 Naples, Italy
    Oncogene 23:5958-67. 2004
    ..Taken together, these results suggest that human thyroid cancers bearing RET/PTC rearrangements may use the CXCR4/SDF-1alpha receptor-ligand pathway to proliferate, survive and migrate...
  33. doi request reprint Papillary thyroid cancer: pathological parameters as prognostic factors in different classes of age
    Paolo Miccoli
    Department of Surgery, University of Pisa, Pisa, Italy
    Otolaryngol Head Neck Surg 138:200-3. 2008
    ..To analyze aspects of a series of papillary thyroid carcinomas and evaluate the prognostic features specific to different age classes...
  34. doi request reprint Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study
    Armando Bartolazzi
    Department of Pathology, St Andrea University Hospital, Rome, Italy
    Lancet Oncol 9:543-9. 2008
    ..We aimed to assess the diagnostic effect of galectin-3 expression analysis in distinguishing preoperatively benign from malignant follicular thyroid nodules when FNA findings were indeterminate...
  35. ncbi request reprint BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas
    Marina N Nikiforova
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 88:5399-404. 2003
    ..They are associated with distinct phenotypical and biological properties of papillary carcinomas and may participate in progression to poorly differentiated and anaplastic carcinomas...
  36. doi request reprint BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer
    Cristina Romei
    Departments of Endocrinology and Metabolism Oncology Surgery, University of Pisa, 56100 Pisa, Italy
    Endocr Relat Cancer 15:511-20. 2008
    ....
  37. ncbi request reprint Mitogenic effects of the up-regulation of minichromosome maintenance proteins in anaplastic thyroid carcinoma
    Teresa Guida
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:4703-9. 2005
    ..Minichromosome maintenance proteins (MCM) 2-7 are required to initiate eukaryotic DNA replication, and their overexpression has been associated with dysplasia and malignancy...
  38. doi request reprint Fine-needle aspiration of thyroid nodules: proteomic analysis to identify cancer biomarkers
    Laura Giusti
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy
    J Proteome Res 7:4079-88. 2008
    ..These findings illustrate the potential use of FNA proteomics to identify protein changes associated with thyroid cancer and to advance potential protein biomarkers in the diagnostic classification of the disease...
  39. ncbi request reprint Regulation of telomerase and its hTERT messenger in colorectal cancer
    Laura Boldrini
    Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Via Roma 57, I 56126 Pisa, Italy
    Oncol Rep 11:395-400. 2004
    ..Both telomerase activity (p=0.014) and hTERT expression (p=0.03) were significantly associated with p53 mutations, suggesting a role of p53 in the signaling pathway for telomerase control...
  40. ncbi request reprint Incidental thyroid carcinoma in a large series of consecutive patients operated on for benign thyroid disease
    Paolo Miccoli
    Department of Surgery, University of Pisa, Pisa, Italy
    ANZ J Surg 76:123-6. 2006
    ..The diagnosis of incidental thyroid carcinoma (ITC) in patients operated on for a benign disease is frequent. This study aims to determine both its clinical effect and the possibility of identifying this class of patients preoperatively...
  41. ncbi request reprint Galectin-3 and oncofetal-fibronectin expression in thyroid neoplasia as assessed by reverse transcription-polymerase chain reaction and immunochemistry in cytologic and pathologic specimens
    Riccardo Giannini
    Department of Oncology, University of Pisa, Pisa, Italy
    Thyroid 13:765-70. 2003
    ....
  42. ncbi request reprint Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2)
    Francesca Carlomagno
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c o Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita Federico II, 80131 Naples, Italy
    J Clin Endocrinol Metab 88:1897-902. 2003
    ..Finally, PP2 blocked invasion of type I collagen matrix by TPC1 cells. Thus, pyrazolopirimidines hold promise for the treatment of human cancers sustaining oncogenic activation of RET...
  43. ncbi request reprint Simian virus 40-like sequences from early and late regions in human thyroid tumors of different histotypes
    Agnese Vivaldi
    Department of Endocrinology and Metabolism, Section of Endocrinology, University of Pisa School of Medicine, 56100 Pisa, Italy
    J Clin Endocrinol Metab 88:892-9. 2003
    ..The presence of the SV40 footprint in PBMC implies that blood cells are vectors of the virus in other tissues of the host...
  44. ncbi request reprint Immunohistochemical and molecular study of radiation-induced multiple meningiomas with pleural and pulmonary metastasis
    Sabina Pistolesi
    Department of Surgery, University of Pisa, Italy
    Tumori 90:328-32. 2004
    ..Thus, the data illustrate the importance of searching for genetic aberrations (which are a hallmark of malignancy) in meningiomas, as predictive and reliable factors of the possibility to recur and to metastasize...
  45. ncbi request reprint Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness
    Valentina Guarino
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita di Napoli Federico II, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:5270-8. 2005
    ..We previously reported that osteopontin (OPN), a secreted glycoprotein that functions as a ligand for CD44v6, is overexpressed in thyrocytes transformed by the RET/PTC oncogene...
  46. ncbi request reprint Interleukin-8 in non-small cell lung carcinoma: relation with angiogenic pattern and p53 alterations
    Laura Boldrini
    Department of Surgery, University of Pisa, Pisa, Italy
    Lung Cancer 50:309-17. 2005
    ..However, in our samples IL-8 levels did not significantly affect prognosis of NSCLC; more studies are required to elucidate the precise role of IL-8 in a large series of patients with non-small cell lung carcinoma...
  47. ncbi request reprint Tumour necrosis factor-alpha: prognostic role and relationship with interleukin-8 and endothelin-1 in non-small cell lung cancer
    Laura Boldrini
    Department of Surgery, University of Pisa, I 56126 Pisa, Italy
    Int J Mol Med 17:887-92. 2006
    ..Our study may also contribute to advancing the knowledge of the molecular relationship between cytokines and endothelial functions in NSCLC...
  48. ncbi request reprint Medullary and papillary tumors are frequently associated in the same thyroid gland without evidence of reciprocal influence in their biologic behavior
    Rosa Paula Biscolla
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Thyroid 14:946-52. 2004
    ..Moreover, although we cannot completely exclude a shared pathogenic event as the cause of both MTC and PTC, the molecular analysis of RET gene alterations did not show any common mutation...
  49. ncbi request reprint Cytotoxic effects of carboplatinum and epirubicin in the setting of an elevated serum thyrotropin for advanced poorly differentiated thyroid cancer
    Ferruccio Santini
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 87:4160-5. 2002
    ..In conclusion, the response rate of poorly differentiated thyroid cancer to chemotherapy observed in this study was favorable and promising. TSH stimulation may have contributed to these results...
  50. ncbi request reprint The heterogeneous distribution of BRAF mutation supports the independent clonal origin of distinct tumor foci in multifocal papillary thyroid carcinoma
    Riccardo Giannini
    Departments of Surgery, University of Pisa, 56126 Pisa, Italy
    J Clin Endocrinol Metab 92:3511-6. 2007
    ..In rare cases, the simultaneous presence of PTC foci of different histopathological subtypes points to independent sites of tumor formation...
  51. ncbi request reprint Presence of BRAF V600E in very early stages of papillary thyroid carcinoma
    Clara Ugolini
    Department of Surgery, University of Pisa, Pisa, Italy
    Thyroid 17:381-8. 2007
    ..Although IM are in general considered of little clinical significance their potential malignant behavior cannot be ignored. BRAF(V600E) mutation has emerged as the most prevalent genetic alteration in PTC...
  52. ncbi request reprint Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of papillary thyroid carcinoma
    Giuliana Salvatore
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche and Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, 80131 Napoli, Italy
    J Clin Endocrinol Metab 89:5175-80. 2004
    ..These results indicate that BRAF mutation and RET/PTC rearrangements are molecular markers of PTC that can be applied to FNA in adjunct to traditional cytology...
  53. ncbi request reprint Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma
    Cristiana Lupi
    Departments of Surgery and Endocrinology, University of Pisa, 56126 Pisa, Italy
    J Clin Endocrinol Metab 92:4085-90. 2007
    ....
  54. ncbi request reprint Meningeal hemangiopericytoma metastatic to the adrenal gland with multiple metastases to bones and lungs: a case report
    Sabina Pistolesi
    Department of Surgery, University of Pisa, Italy
    Tumori 90:147-50. 2004
  55. ncbi request reprint Clinically unpredictable prognostic factors in the outcome of medullary thyroid cancer
    Paolo Miccoli
    Department of Surgery, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Endocr Relat Cancer 14:1099-105. 2007
    ....
  56. ncbi request reprint Osteopontin expression and prognostic significance in non-small cell lung cancer
    Valentina Donati
    Division of Surgical Pathology, Departments of Surgery, University of Pisa, Italy
    Clin Cancer Res 11:6459-65. 2005
    ..The purpose of this study was to better define the role of osteopontin in non-small cell lung cancer biology by determining its prognostic significance...
  57. ncbi request reprint Expression of endothelin-1 is related to poor prognosis in non-small cell lung carcinoma
    Laura Boldrini
    Department of Surgery, University of Pisa, 56100 Pisa, Italy
    Eur J Cancer 41:2828-35. 2005
    ..04, respectively). We conclude that ET-1 could be involved in angiogenic phenomena in NSCLC and may represent a further indicator of progression and poor prognosis in this type of cancer, with interesting therapeutic implications...
  58. pmc Proliferative activity of extracellular HIV-1 Tat protein in human epithelial cells: expression profile of pathogenetically relevant genes
    Alessia A Bettaccini
    Dipartimento di Scienze Cliniche e Biologiche, Universita dell Insubria, Varese, Italy
    BMC Microbiol 5:20. 2005
    ..The activity of two-exon (aa 1-101) and synthetic (aa 1-86) Tat was studied on mammary and amniotic epithelial cells cultured under low serum conditions...
  59. ncbi request reprint Expression and mutational status of c-kit in small-cell lung cancer: prognostic relevance
    Laura Boldrini
    Departments of Surgery, Oncology, Transplants and Advanced Technologies in Medicine, and Cardio Thoracic Surgery, University of Pisa, Pisa, Italy
    Clin Cancer Res 10:4101-8. 2004
    ..We examined c-kit expression and mutational status in SCLC to verify its putative expression and genetic alterations, as well as its eventual prognostic impact...
  60. ncbi request reprint Applications of tissue microarray technology in immunohistochemistry: a study on c-kit expression in small cell lung cancer
    Valentina Donati
    Department of Surgery, Division of Surgical Pathology, University of Pisa, Italy
    Hum Pathol 35:1347-52. 2004
    ..4%). Moreover, a high percentage (13.4%) of cores was lost, and this loss was not random. To sum up, in our experience, tissue microarray technology cannot be a substitute for whole sections in clinical diagnosis of individual cases...
  61. ncbi request reprint Galectin-3 is highly expressed in nonencapsulated papillary thyroid carcinoma but weakly expressed in encapsulated type; comparison with Hector Battifora mesothelial cell 1 immunoreactivity
    Liborio Torregrossa
    Department of Surgery, Division of Anatomic Pathology, University of Pisa, 56100 Pisa, Italy
    Hum Pathol 38:1482-8. 2007
    ..Our data suggest that gal-3 immunodetection alone is not able to support the diagnosis of encapsulated FVPTCs...
  62. ncbi request reprint Lymphocyte and immature dendritic cell infiltrates in differentiated, poorly differentiated, and undifferentiated thyroid carcinoma
    Clara Ugolini
    Division of Pathology, Department of Surgery, University of Pisa, Pisa, Italy
    Thyroid 17:389-93. 2007
    ..The infiltration of lymphocytes and immature CD1a+ dendritic cells (DC) was characterized in papillary, poorly differentiated (PDC), and undifferentiated (UC) carcinomas to evaluate their association with immunological infiltrates...
  63. ncbi request reprint WWOX expression in different histologic types and subtypes of non-small cell lung cancer
    Valentina Donati
    Department of Surgery, Division of Anatomic Pathology and Cardio Thoracic Surgery, University of Pisa and Scuola Normale Superiore and Istituto Nazionale di Fisica Nucleare, Section of Pisa, Pisa, Italy
    Clin Cancer Res 13:884-91. 2007
    ..The purpose of this study is to better define the role of WWOX in NSCLC tumorigenesis and progression by determining its pathogenetic and prognostic significance...