Corrado Barbui

Summary

Affiliation: University of Verona
Country: Italy

Publications

  1. pmc A new approach to psychiatric drug approval in Europe
    Corrado Barbui
    WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
    PLoS Med 10:e1001530. 2013
  2. doi request reprint Antipsychotic drug exposure and risk of venous thromboembolism: a systematic review and meta-analysis of observational studies
    Corrado Barbui
    Section of Psychiatry, Department of Public Health and Community Medicine, University of Verona, Policlinico GB Rossi, Piazzale Scuro 10, 37134, Verona, Italy
    Drug Saf 37:79-90. 2014
  3. pmc Schizophrenia trials conducted in African countries: a drop of evidence in the ocean of morbidity?
    Marianna Purgato
    Division of Psychiatry, University of Nottingham, Nottingham, UK
    Int J Ment Health Syst 6:9. 2012
  4. pmc Making the use of psychotropic drugs more rational through the development of GRADE recommendations in specialist mental healthcare
    Giovanni Ostuzzi
    WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Medicine and Public Health, Section of Psychiatry, University of Verona, Verona, Italy
    Int J Ment Health Syst 7:14. 2013
  5. pmc Geneva calling: WHO resolution on mental disorders
    Corrado Barbui
    WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
    Int J Ment Health Syst 6:6. 2012
  6. pmc Forty-five years of schizophrenia trials in Italy: a survey
    Marianna Purgato
    Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Italy
    Trials 13:35. 2012
  7. pmc Using the needs of WHO to prioritise Cochrane reviews: The case of antipsychotic drugs
    Marianna Purgato
    Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    Int J Ment Health Syst 5:25. 2011
  8. ncbi request reprint Drug treatment modalities in psychiatric inpatient practice: a 20-year comparison
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Ospedale Policlinico, 37134 Verona, Italy
    Eur Arch Psychiatry Clin Neurosci 255:136-42. 2005
  9. ncbi request reprint CNS drugs approved by the centralised European procedure: true innovation or dangerous stagnation?
    Corrado Barbui
    Section of Psychiatry and Clinical Psychology, University of Verona, Policlinico GB Rossi, Piazzale Scuro 10, 37134, Verona, Italy
    Psychopharmacology (Berl) 190:265-8. 2007
  10. ncbi request reprint Psychotropic drug epidemiology: the road travelled, the road ahead
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychiatry, University of Verona, Policlinico GB Rossi, 37134 Verona, Italy
    Int Rev Psychiatry 17:143-51. 2005

Detail Information

Publications115 found, 100 shown here

  1. pmc A new approach to psychiatric drug approval in Europe
    Corrado Barbui
    WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
    PLoS Med 10:e1001530. 2013
    b>Corrado Barbui and Irene Bighelli question the current rules governing registration of new medicines in Europe, using the example of psychiatric drugs, and argue that the concept of absolute efficacy should be replaced by the concept of ..
  2. doi request reprint Antipsychotic drug exposure and risk of venous thromboembolism: a systematic review and meta-analysis of observational studies
    Corrado Barbui
    Section of Psychiatry, Department of Public Health and Community Medicine, University of Verona, Policlinico GB Rossi, Piazzale Scuro 10, 37134, Verona, Italy
    Drug Saf 37:79-90. 2014
    ..Case reports and observational studies published in the early 1950s suggested that antipsychotic (AP) drugs may represent a risk factor, while observational studies conducted in the last 3 decades have provided conflicting results...
  3. pmc Schizophrenia trials conducted in African countries: a drop of evidence in the ocean of morbidity?
    Marianna Purgato
    Division of Psychiatry, University of Nottingham, Nottingham, UK
    Int J Ment Health Syst 6:9. 2012
    ..abstract:..
  4. pmc Making the use of psychotropic drugs more rational through the development of GRADE recommendations in specialist mental healthcare
    Giovanni Ostuzzi
    WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Medicine and Public Health, Section of Psychiatry, University of Verona, Verona, Italy
    Int J Ment Health Syst 7:14. 2013
    ..This paper describes the experience of a working group of psychiatrists who adopted the GRADE approach to develop clinical recommendations on the use of psychotropic drugs in specialist mental healthcare...
  5. pmc Geneva calling: WHO resolution on mental disorders
    Corrado Barbui
    WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
    Int J Ment Health Syst 6:6. 2012
    ..abstract:..
  6. pmc Forty-five years of schizophrenia trials in Italy: a survey
    Marianna Purgato
    Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Italy
    Trials 13:35. 2012
    ..In addition, we evaluated change over time in three keys aspects: sample size, follow-up duration, and number of outcomes...
  7. pmc Using the needs of WHO to prioritise Cochrane reviews: The case of antipsychotic drugs
    Marianna Purgato
    Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    Int J Ment Health Syst 5:25. 2011
    ..abstract:..
  8. ncbi request reprint Drug treatment modalities in psychiatric inpatient practice: a 20-year comparison
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Ospedale Policlinico, 37134 Verona, Italy
    Eur Arch Psychiatry Clin Neurosci 255:136-42. 2005
    ....
  9. ncbi request reprint CNS drugs approved by the centralised European procedure: true innovation or dangerous stagnation?
    Corrado Barbui
    Section of Psychiatry and Clinical Psychology, University of Verona, Policlinico GB Rossi, Piazzale Scuro 10, 37134, Verona, Italy
    Psychopharmacology (Berl) 190:265-8. 2007
  10. ncbi request reprint Psychotropic drug epidemiology: the road travelled, the road ahead
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychiatry, University of Verona, Policlinico GB Rossi, 37134 Verona, Italy
    Int Rev Psychiatry 17:143-51. 2005
    ....
  11. ncbi request reprint Explanatory and pragmatic trials
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Piazzale L A Scuro, 10 37134 Verona, Italy
    Epidemiol Psichiatr Soc 16:124-5. 2007
  12. ncbi request reprint Sex differences in the subjective tolerability of antipsychotic drugs
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Italy
    J Clin Psychopharmacol 25:521-6. 2005
    ..Studies should no longer consider men and women as a homogeneous group, given that the subjective tolerability of antipsychotic drugs substantially differs between sexes...
  13. ncbi request reprint Health status, resource consumption, and costs of dysthymia. A multi-center two-year longitudinal study
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Ospedale Policlinico, 37134 Verona, Italy
    J Affect Disord 90:181-6. 2006
    ..In this study we estimated the health status, resource consumption and costs of a large cohort of patients with early and late-onset dysthymia...
  14. ncbi request reprint Development of a registry for monitoring psychotropic drug prescriptions: aims, methods and implications for ordinary practice and research
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry, University of Verona, Italy
    Int J Methods Psychiatr Res 14:151-7. 2005
    ....
  15. ncbi request reprint Persistence with polypharmacy and excessive dosing in patients with schizophrenia treated in four European countries
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    Int Clin Psychopharmacol 21:355-62. 2006
    ..Clinicians should consider that dose reduction strategies have been shown to be a feasible intervention in patients with schizophrenia...
  16. ncbi request reprint Identification and management of depression in primary care settings. A meta-review of evidence
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, University of Verona, Verona, Italy
    Epidemiol Psichiatr Soc 15:276-83. 2006
    ....
  17. ncbi request reprint Evidence-based psychopharmacology: an agenda for the future
    C Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    Evid Based Ment Health 10:4-6. 2007
  18. ncbi request reprint Decision models in the evaluation of psychotropic drugs : useful tool or useless toy?
    Corrado Barbui
    Dept Medicine and Public Health, Section of Psichiatry and Clinical Psichology, University of Verona, Italy
    Eur J Health Econ 7:173-5. 2006
    ..In this commentary, taking the olanzapine vs. risperidone model as an example, arguments are provided to support this statement...
  19. ncbi request reprint Factors associated with antipsychotic dosing in psychiatric inpatients: a prospective study
    Corrado Barbui
    Section of Psychiatry and Clinical Psychology, Department of Medicine and Public Health, University of Verona, Verona, Italy
    Int Clin Psychopharmacol 22:221-5. 2007
    ..Clinicians should consider that concurrent prescribing of two or more antipsychotic agents increases the probability of administering excessive dosing in the long-term...
  20. pmc Effectiveness of paroxetine in the treatment of acute major depression in adults: a systematic re-examination of published and unpublished data from randomized trials
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, World Health Organization Collaborating Centre for Research and Training in Mental Health, University of Verona, Verona, Italy
    CMAJ 178:296-305. 2008
    ..We undertook a systematic review of published and unpublished clinical trial data to determine the effectiveness and acceptability of paroxetine...
  21. pmc Does the addition of a second antipsychotic drug improve clozapine treatment?
    Corrado Barbui
    Schizophr Bull 35:458-68. 2009
    ..91, 95% CI = 0.75 to 1.11). We conclude that the evidence base supporting a second antipsychotic in addition to clozapine in partially responsive patients with schizophrenia is weak. This weak evidence indicates modest to absent benefit...
  22. ncbi request reprint Validity of the impact factor of journals as a measure of randomized controlled trial quality
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
    J Clin Psychiatry 67:37-40. 2006
    ..To assess whether the impact factor, a measure of the frequency with which journal articles are cited in the scientific literature, is a proxy measure of the quality of articles reporting the results of randomized controlled trials...
  23. ncbi request reprint Determinants of first- and second-generation antipsychotic drug use in clinically unstable patients with schizophrenia treated in four European countries
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Italy
    Int Clin Psychopharmacol 21:73-9. 2006
    ..Physicians tended to reserve polypharmacy for difficult-to-treat patients (i.e. for managing situations where, despite the lack of an evidence base, there is a pressing need to provide clinical answers)...
  24. pmc Efficacy of antidepressants and benzodiazepines in minor depression: systematic review and meta-analysis
    Corrado Barbui
    Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, University of Verona, Policlinico GB Rossi, 37134 Verona, Italy
    Br J Psychiatry 198:11-6, sup 1. 2011
    ..Depression is a common condition that has been frequently treated with psychotropics...
  25. doi request reprint Aripiprazole versus haloperidol in combination with clozapine for treatment-resistant schizophrenia in routine clinical care: a randomized, controlled trial
    Corrado Barbui
    World Health Organization Collaborating Centre for Research and Training in Mental Health and Service Organization, Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, Verona, Italy
    J Clin Psychopharmacol 31:266-73. 2011
    ..However, an advantage in the perception of adverse effects with aripiprazole treatment may be meaningful for patients...
  26. ncbi request reprint Off-label and non-classical prescriptions of antipsychotic agents in ordinary in-patient practice
    C Barbui
    Department of Medicine and Public Health, Section of Psychiatry, University of Verona, Ospedale Policlinico, 37134 Verona, Italy
    Acta Psychiatr Scand 109:275-8. 2004
    ..To estimate the proportion of off-label prescriptions of antipsychotics (APs) in ordinary in-patient practice...
  27. ncbi request reprint Amitriptyline for inpatients and SSRIs for outpatients with depression? Systematic review and meta-regression analysis
    C Barbui
    Department of Medicine and Public Health, Section of Psychiatry, University of Verona, Italy
    Pharmacopsychiatry 37:93-7. 2004
    ..The aim of this study was to investigate the contribution of study setting on outcome in clinical trials comparing amitriptyline with any other AD...
  28. ncbi request reprint Economic evaluation of antidepressive agents: a systematic critique of experimental and observational studies
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry, University of Verona, Italy
    J Clin Psychopharmacol 23:145-54. 2003
    ..Taken together, available pharmacoeconomic studies indicate that tricyclic drugs and selective serotonin reuptake inhibitors have similar cost effectiveness in the health care systems where these comparisons have been made...
  29. ncbi request reprint Cross-sectional database analysis of antidepressant prescribing in Italy
    Corrado Barbui
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Clin Psychopharmacol 23:31-4. 2003
    ..The high proportion of occasional antidepressant users suggests that clinical trials should follow all patients, without excluding those who fail to continue the study medication...
  30. ncbi request reprint "Wish bias" in antidepressant drug trials?
    Corrado Barbui
    Section of Psychiatry, Department of Medicine and Public Health, University of Verona, Verona, Italy
    J Clin Psychopharmacol 24:126-30. 2004
    ..The evidence that the outcome of fluoxetine trials varied according to whether this drug was used as a new compound or a reference one suggests the presence of bias...
  31. ncbi request reprint Prescribing second-generation antipsychotics and the evolving standard of care in Italy
    C Barbui
    Laboratory of Epidemiology and Social Psychiatry, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Pharmacopsychiatry 35:239-43. 2002
    ....
  32. ncbi request reprint [Everyday evidence and practice based medicine: an issue of antidepressants]
    Corrado Barbui
    Dipartimento di Medicina e Sanita Pubblica, Sezione di Psichiatria, Universita di Verona, Ospedale Policlinico, 37134 Verona
    Epidemiol Psichiatr Soc 11:152-8. 2002
  33. ncbi request reprint Fluoxetine dose and outcome in antidepressant drug trials
    Corrado Barbui
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur J Clin Pharmacol 58:379-86. 2002
    ..The present study compared fluoxetine dose and outcome in trials in which fluoxetine was the experimental drug with trials in which it was the comparator...
  34. ncbi request reprint [Systematic review and clinical decisions in psychiatry]
    Corrado Barbui
    Dipartimento di Medicina e Sanita Pubblica, Sezione di Psichiatria, Universita di Verona, Policlinico G B Rossi, P le L A Scuro 10, 37134 Verona
    Epidemiol Psichiatr Soc 12:154-9. 2003
  35. doi request reprint Comparison of patient and clinician perspectives in the assessment of antipsychotic medication adherence
    Corrado Barbui
    Section of Psychiatry and Clinical Psychology, Department of Medicine and Public Health, University of Verona, Verona, Italy
    Psychopathology 42:311-7. 2009
    ..Factors influencing patient and clinician perspectives in the assessment of medication adherence have never been compared...
  36. ncbi request reprint What are evidence-based treatment recommendations?
    C Barbui
    Section of Psychiatry and Clinical Psychology, Department of Public Health and Community Medicine, University of Verona, Verona, Italy
    Epidemiol Psychiatr Sci 20:29-31. 2011
    ..This article briefly presents how this methodology may be employed to develop treatment recommendations that might constitute a permanent infrastructure between primary research and everyday clinical practice...
  37. doi request reprint Aripiprazole versus haloperidol in combination with clozapine for treatment-resistant schizophrenia: a 12-month, randomized, naturalistic trial
    Andrea Cipriani
    Section of Psychiatry, Department of Public Health and Community Medicine, University of Verona, Italy
    J Clin Psychopharmacol 33:533-7. 2013
    ..Long-term studies for patients with resistant schizophrenia are necessary to assess the effectiveness of combination strategies on persisting positive symptoms...
  38. ncbi request reprint Determinants of antipsychotic polypharmacy in psychiatric inpatients: a prospective study
    Bruno Biancosino
    Section of Psychiatry, Department of Medical Sciences of Communication and Behaviour, University of Ferrara, Ferrara, Italy
    Int Clin Psychopharmacol 20:305-9. 2005
    ..Conversely, the theoretical advantage of avoiding a high dose of a single drug is counterbalanced by the documented disadvantage of administering high total doses...
  39. pmc Rationale and design of an independent randomised controlled trial evaluating the effectiveness of aripiprazole or haloperidol in combination with clozapine for treatment-resistant schizophrenia
    Michela Nose
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Italy
    Trials 10:31. 2009
    ....
  40. ncbi request reprint Does randomized evidence support sertraline as first-line antidepressant for adults with acute major depression? A systematic review and meta-analysis
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Policlinico G B Rossi, Piazzale L A Scuro, 10, 37134 Verona, Italy
    J Clin Psychiatry 69:1732-42. 2008
    ..The aim of this study was to carry out a systematic review and meta-analysis to compare sertraline with any other antidepressant in the acute phase treatment of major depression at 8 weeks...
  41. doi request reprint Duloxetine versus other anti-depressive agents for depression
    Andrea Cipriani
    Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
    Cochrane Database Syst Rev 10:CD006533. 2012
    ....
  42. ncbi request reprint Antidepressant drug use in Lombardy, Italy: a population-based study
    Mauro Percudani
    Health Care Directorate, Region of Lombardy, Milan, Italy
    J Affect Disord 83:169-75. 2004
    ..In the present study, we examined the prevalence and distribution of antidepressant prescribing in Lombardy, a northern Italy region of nine million inhabitants...
  43. ncbi request reprint Is the Defined Daily Dose system a reliable tool for standardizing antipsychotic dosages?
    Michela Nose
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Italy
    Int Clin Psychopharmacol 23:287-90. 2008
    ..In conclusion, this study found that the DDD system is a reliable tool for standardizing antipsychotic doses in drug utilization research...
  44. ncbi request reprint Cerebral atrophy and white matter disruption in chronic schizophrenia
    Nicola Andreone
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    Eur Arch Psychiatry Clin Neurosci 257:3-11. 2007
    ..It also suggested that physiological aging effects on brain anatomy may be abnormally pronounced in schizophrenia...
  45. ncbi request reprint Prevalence, incidence and persistence of antipsychotic drug prescribing in the Italian general population: retrospective database analysis, 1999-2002
    Mersia Mirandola
    Servizio Farmaceutico ULSS 20, Verona, Italy
    Pharmacoepidemiol Drug Saf 15:412-20. 2006
    ..To investigate the prevalence, incidence and persistence with antipsychotic drug therapy in a large and geographically defined catchment area of Italian general population...
  46. doi request reprint Citalopram versus other anti-depressive agents for depression
    Andrea Cipriani
    Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
    Cochrane Database Syst Rev 7:CD006534. 2012
    ..Citalopram, one of the first selective serotonin reuptake inhibitors (SSRI) introduced in the market, is one of these antidepressant drugs that clinicians use for routine depression care...
  47. ncbi request reprint Epidemiological impact of antidepressant and antipsychotic drugs on the general population
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Italy
    Curr Opin Psychiatry 19:405-10. 2006
    ....
  48. ncbi request reprint Past use of selective serotonin reuptake inhibitors and the risk of cerebrovascular events in the elderly
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Italy
    Int Clin Psychopharmacol 20:169-71. 2005
    ..31, 95% CI 0.87-1.97). Although the risk of cerebrovascular accidents is a rare but serious event that should carefully be monitored during antidepressant therapy, this study indicated an absence of difference between TCAs and SSRIs...
  49. pmc Effectiveness of lithium in subjects with treatment-resistant depression and suicide risk: a protocol for a randomised, independent, pragmatic, multicentre, parallel-group, superiority clinical trial
    Andrea Cipriani
    Dipartimento di Sanità Pubblica e Medicina di Comunità, Sezione di Psichiatria e Sezione di Psicologia Clinica, Universita di Verona, Policlinico G, B, Rossi Piazzale L A Scuro, Verona, 10 37134, Italy
    BMC Psychiatry 13:212. 2013
    ....
  50. doi request reprint Adverse effects of antipsychotic drugs: survey of doctors' versus patients' perspective
    Michela Nose
    Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, University of Verona, Policlinico GB Rossi, 37134 Verona, Italy
    Soc Psychiatry Psychiatr Epidemiol 47:157-64. 2012
    ..The aim of this survey is to compare doctors' versus patients' perspective on the presence and level of distress due to antipsychotic adverse effects in a sample of patients under the care of the South-Verona mental health services...
  51. ncbi request reprint Benzodiazepine use in the real world of psychiatric practice: low-dose, long-term drug taking and low rates of treatment discontinuation
    Antonio Veronese
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Ospedale Policlinico, 37134, Verona, Italy
    Eur J Clin Pharmacol 63:867-73. 2007
    ....
  52. ncbi request reprint Understanding antipsychotic non-classical prescriptions: a quantitative and qualitative approach
    Antonio Veronese
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Piazzale L A Scuro 10, 37134 Verona, Italy
    Epidemiol Psichiatr Soc 17:236-41. 2008
    ..The present study was carried out to develop concepts which help understand this phenomenon in a natural setting, giving emphasis to views of clinicians according to quali - quantitative research methodologies...
  53. ncbi request reprint Impact of regulatory changes on first- and second-generation antipsychotic drug consumption and expenditure in Italy
    Margherita Andretta
    Servizio Farmaceutico, ULSS 20, Verona, Italy
    Soc Psychiatry Psychiatr Epidemiol 40:72-7. 2005
    ..In 1994 a change in drug reimbursement status was implemented in Italy according to cost-effectiveness criteria. The aim of this study was to examine the impact of these changes on the use of antipsychotic (AP) drugs...
  54. ncbi request reprint Sertraline versus other antidepressive agents for depression
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Policlinico G B Rossi, Piazzale L A Scuro, 10, Verona, Italy, 37134
    Cochrane Database Syst Rev 4:CD006117. 2010
    ..However, the included studies did not report on all the outcomes that were pre-specified in the protocol of this review. Outcomes of clear relevance to patients and clinicians were not reported in any of the included studies...
  55. ncbi request reprint Seven criteria for improving effectiveness trials in psychiatry
    Michele Tansella
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Italy
    Psychol Med 36:711-20. 2006
    ..There are no published criteria for improving the quality of effectiveness of randomized controlled trials (RCTs) in psychiatry...
  56. pmc Selective serotonin reuptake inhibitors and risk of suicide: a systematic review of observational studies
    Corrado Barbui
    World Health Organization Collaborating Centre for Research and Training in Mental Health, Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    CMAJ 180:291-7. 2009
    ..We explored the association between exposure to SSRIs and risk of suicide completion or attempt...
  57. ncbi request reprint Are we going to increase the use of antidepressants up to that of benzodiazepines?
    Arcangelo Ciuna
    Servizio Farmaceutico ULSS 20, Verona, Italy
    Eur J Clin Pharmacol 60:629-34. 2004
    ..We investigated whether the increasing use of antidepressants is associated with a progressive reduction in benzodiazepine use...
  58. ncbi request reprint Second-generation antipsychotics and risk of cerebrovascular accidents in the elderly
    Mauro Percudani
    Health Care Directorate, Region of Lombardy, Milan, Italy
    J Clin Psychopharmacol 25:468-70. 2005
    ..12-1.93). These data provide preliminary epidemiological evidence that exposure to SGAs, in comparison with exposure to first-generation antipsychotics, significantly increased the risk of cerebrovascular accidents in the elderly...
  59. ncbi request reprint Relationship between quality of reports of antidepressant randomized controlled trials and treatment estimates: systematic review, meta-analysis, and meta-regression analysis
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    J Clin Psychopharmacol 27:352-6. 2007
    ..However, current quality measures are not related with treatment estimates in antidepressant trials and may not be useful weighting tools when meta-analyses of data extracted from antidepressant RCTs are carried out...
  60. doi request reprint Antidepressant drug prescription and risk of abnormal bleeding: a case-control study
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, WHO Collaborating Centre for Research and Training in Mental Health, University of Verona, Italy
    J Clin Psychopharmacol 29:33-8. 2009
    ..74; 95% CI, 1.04-2.93). In a population with a low baseline risk of bleeding, we detected a significant increase in the risk of gastrointestinal bleeding only...
  61. ncbi request reprint Clinical interventions for treatment non-adherence in psychosis: meta-analysis
    Michela Nose
    Department of Medicine and Public Health, Section of Psychiatry, University of Verona, Italy
    Br J Psychiatry 183:197-206. 2003
    ..Studies investigating the efficacy of clinical interventions for reducing treatment non-adherence have generated contrasting findings, and treatment non-adherence remains common in clinical practice...
  62. ncbi request reprint Efficacy of pharmacotherapy against core traits of borderline personality disorder: meta-analysis of randomized controlled trials
    Michela Nose
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Italy
    Int Clin Psychopharmacol 21:345-53. 2006
    ..00, -0.11). No difference was observed between pharmacotherapy and placebo in terms of participants leaving the study early. Pharmacotherapy can exert a modest beneficial effect on some core traits of borderline personality disorder...
  63. doi request reprint Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis
    Andrea Cipriani
    Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, University of Verona, Italy
    Lancet 378:1306-15. 2011
    ..We did a multiple-treatments meta-analysis, which accounted for both direct and indirect comparisons, to assess the effects of all antimanic drugs...
  64. ncbi request reprint Antidepressant drug prescribing among elderly subjects: a population-based study
    Mauro Percudani
    Health Care Directorate, Region of Lombardy, Milan, Italy
    Int J Geriatr Psychiatry 20:113-8. 2005
    ..In the present study we examined the prevalence and distribution of antidepressant prescribing in Lombardy, a northern Italy region with more than one and a half million elderly inhabitants...
  65. ncbi request reprint Antipsychotic drug prescribing in the elderly is cause for concern
    Mauro Percudani
    Health Care Directorate, Region of Lombardy, Milan, Italy
    Int Clin Psychopharmacol 19:347-50. 2004
    ....
  66. ncbi request reprint Are all antidepressants really the same? The case of fluoxetine: a systematic review
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    J Clin Psychiatry 67:850-64. 2006
    ..To systematically review the efficacy and tolerability of fluoxetine, the most widely studied of newer antidepressants, in comparison with all other antidepressants in the acute treatment of depression in patients aged more than 18 years...
  67. ncbi request reprint Assessment of cerebral blood volume in schizophrenia: A magnetic resonance imaging study
    Paolo Brambilla
    Department of Pathology and Experimental and Clinical Medicine, Section of Psychiatry, University of Udine, Udine, Italy
    J Psychiatr Res 41:502-10. 2007
    ..Thus, altered intracranial hemodynamics may accompany brain atrophy and cognitive deficits, being a crucial factor in the pathophysiology of schizophrenia...
  68. ncbi request reprint Violence in psychiatric units: a 7-year Italian study of persistently assaultive patients
    Luigi Grassi
    Section of Psychiatry, Department of Medical Sciences of Communication and Behaviour, University of Ferrara, Ferrara, Italy
    Soc Psychiatry Psychiatr Epidemiol 41:698-703. 2006
    ..The aim of this paper is to describe the characteristics of repeated episodes of violence among patients admitted to an Italian psychiatric ward...
  69. ncbi request reprint Head-to-head comparison of the costs of atypical antipsychotics: a systematic review
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    CNS Drugs 19:935-50. 2005
    ..As healthcare providers in different settings are ultimately the ones who pay for new innovations, it seems appropriate that they commission research into the cost effectiveness of SGAs...
  70. ncbi request reprint Routine outcome monitoring in clinical practice: service and non-service costs of psychiatric patients attending a Community Mental Health Centre in Italy
    Mauro Percudani
    Department of Mental Health, Hospital of Legnano, Via Candiani 2, 20025 Legnano, Milan, Italy
    Eur Psychiatry 19:469-77. 2004
    ..This study estimated service and non-service costs in a random sample of patients attending a community psychiatric mental health centre in Italy...
  71. ncbi request reprint Relationship between self-reported and observer-reported ratings for psychopathology in psychiatric inpatients
    Bruno Biancosino
    Section of Psychiatry, Department of Medical Sciences of Communication and Behaviour, University of Ferrara, Ferrara, Italy
    Psychopathology 40:418-23. 2007
    ..Psychopathology can be measured adopting the perspective of clinicians or the perspective of patients themselves. In the present study, we investigated the degree of coherence between these two viewpoints...
  72. ncbi request reprint Health status, resource consumption, and costs of dysthymic patients in Italian primary care
    Corrado Barbui
    Laboratory of Epidemiology and Social Psychiatry, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Epidemiol Psichiatr Soc 13:120-5. 2004
    ..To describe the health status, resource consumption and costs of patients with dysthymic disorder in the Italian primary care setting...
  73. ncbi request reprint [Systemic review of clinical interventions for reducing treatment non-adherence in psychosis]
    Michela Nose
    Dipartimento di Medicina e Sanita Pubblica, Sezione di Psichiatria, Universita di Verona, Policlinico G B Rossi, P le L A Scuro 10, 37134 Verona
    Epidemiol Psichiatr Soc 12:272-86. 2003
    ..This systematic review was carried out to investigate the efficacy of clinical interventions that community psychiatric services can implement to reduce non-adherence in patients with psychosis...
  74. ncbi request reprint Generating psychotropic drug exposure data from computer-based medical records
    Chiara Bonetto
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    Comput Methods Programs Biomed 83:120-4. 2006
    ..To develop a methodology for extracting psychotropic drug exposure data from computer-based medical records and for generating drug exposure variables suitable for secondary use...
  75. ncbi request reprint Cost and outcome implications of using typical and atypical antipsychotics in ordinary practice in Italy
    Mauro Percudani
    Department of Psychiatry, Hospital of Legnano, Milan, Italy
    J Clin Psychiatry 64:1293-9. 2003
    ..This study examined the financial and clinical implications of using atypical antipsychotics in the context of community psychiatric care in Italy...
  76. ncbi request reprint Epidemiology of first- and second-generation antipsychotic agents in Lombardy, Italy
    M Percudani
    Health Care Directorate, Region of Lombardy, Milan, Italy
    Pharmacopsychiatry 38:128-31. 2005
    ..This study investigated the age and gender distribution of antipsychotic prescribing in Lombardy, a region of nine million inhabitants in northern Italy...
  77. ncbi request reprint What is a clinical trial protocol?
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Italy
    Epidemiol Psichiatr Soc 19:116-7. 2010
    ..Trial protocols must meet a standard that adheres to the principles of Good Clinical Practice, and are used to obtain ethics approval by local Ethics Committees or Institutional Review Boards...
  78. ncbi request reprint Patterns of benzodiazepine use in a Canadian population sample
    Eleonora Esposito
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    Epidemiol Psichiatr Soc 18:248-54. 2009
    ....
  79. ncbi request reprint Monitoring community psychiatric services in Italy: differences between patients who leave care and those who stay in treatment
    Mauro Percudani
    Department of Psychiatry, Hospital of Legnano, and Laboratory of Epidemiology and Social Psychiatry, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Br J Psychiatry 180:254-9. 2002
    ..Continuity of care has been monitored rarely in Italian community mental health centres...
  80. doi request reprint Stressful life events and social health factors in women using anxiolytics and antidepressants: an Italian observational study in community pharmacies
    Paola D'Incau
    Department of Community Medicine and Public Health, Section of Clinical Pharmacology Unit, University of Verona, Verona, Italy
    Gend Med 8:80-92. 2011
    ..Women are more likely than men to have experienced poverty, gender discrimination, and physical and sexual abuse...
  81. ncbi request reprint Superiority, equivalence or non-inferiority?
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    Epidemiol Psichiatr Soc 18:311-3. 2009
    ..Three kinds of RCTs may be designed: Superiority trials, Equivalence studies, Non-inferiority studies...
  82. ncbi request reprint Antipsychotic drugs and cerebrovascular events in elderly patients with dementia: a systematic review
    Sara Mazzucco
    Department of Neurological Sciences and Vision, Section of Clinical Neurology, University of Verona, Piazzale L A Scuro, 10, 37134 Verona, Italy
    Mini Rev Med Chem 8:776-83. 2008
    ..Assessing both randomised and non-randomised evidence, this systematic review found conflicting findings, particularly for risperidone. More research is needed to better inform clinical practice...
  83. ncbi request reprint Metareview on short-term effectiveness and safety of antidepressants for depression: an evidence-based approach to inform clinical practice
    Andrea Cipriani
    Department of Medicine and Public Health, University of Verona, Italy
    Can J Psychiatry 52:553-62. 2007
    ....
  84. ncbi request reprint What is a forest plot?
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Piazzale L A Scuro, 10 37134 Verona, Italy
    Epidemiol Psichiatr Soc 15:258-9. 2006
  85. ncbi request reprint What is an individual patient data meta-analysis?
    Andrea Cipriani
    Epidemiol Psichiatr Soc 16:203-4. 2007
  86. ncbi request reprint What is a risk ratio?
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Piazzale L A Scuro, 10, 37134 Verona, Italy
    Epidemiol Psichiatr Soc 16:20-1. 2007
  87. ncbi request reprint What is an intention to treat analysis?
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    Epidemiol Psichiatr Soc 17:26-7. 2008
  88. ncbi request reprint Allocation concealment and blinding in clinical trials
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    Epidemiol Psichiatr Soc 17:115-6. 2008
  89. doi request reprint Mortality and cause of death among psychiatric patients: a 20-year case-register study in an area with a community-based system of care
    L Grigoletti
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Italy
    Psychol Med 39:1875-84. 2009
    ....
  90. ncbi request reprint How often do patients with psychosis fail to adhere to treatment programmes? A systematic review
    M Nose
    Department of Medicine and Public Health, Section of Psychiatry, University of Verona, Verona, Italy
    Psychol Med 33:1149-60. 2003
    ..Its purpose is to provide an overall estimate of treatment non-adherence in community psychiatric services, and to analyse and study patient characteristics explaining the between-study heterogeneity in rates of non-adherence...
  91. ncbi request reprint Avoidable mortality of psychiatric patients in an area with a community-based system of mental health care
    F Amaddeo
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    Acta Psychiatr Scand 115:320-5. 2007
    ....
  92. ncbi request reprint Determinants of subjective quality of life in patients attending community-based mental health services. The South-Verona Outcome Project 5
    M Ruggeri
    Department of Medicine and Public Health, Section of Psychiatry, University of Verona, Italia
    Acta Psychiatr Scand 105:131-40. 2002
    ....
  93. ncbi request reprint Clinical databases of patients receiving antidepressants. The missing link between research and practice?
    Corrado Barbui
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157, Milano, Italy
    J Affect Disord 70:191-6. 2002
    ..Unfortunately, the epidemiology of these compounds has shown significant gaps between recommendations derived from randomised controlled trials and current clinical practice...
  94. ncbi request reprint Clozapine-treated subjects with treatment-resistant schizophrenia: a systematic review of experimental and observational studies
    P Brambilla
    Mario Negri Institute for Pharmacological Research, Milano, Italy
    Int Clin Psychopharmacol 17:189-95. 2002
    ..A new generation of observational studies should be developed to provide evidence on patient outcome in typical settings and under real-world circumstances, and on variables which may affect outcome...
  95. ncbi request reprint Antidepressant drug use in Italy since the introduction of SSRIs: national trends, regional differences and impact on suicide rates
    C Barbui
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Soc Psychiatry Psychiatr Epidemiol 34:152-6. 1999
    ..9 to 3.2 per 100,000. These data suggest that SSRIs gave a new impetus to antidepressant sales. However, possible public health benefits related to the shift from old to new antidepressants have yet to be demonstrated...
  96. ncbi request reprint Drug epidemiology in Italy: methods and ethical issues. The example of psychiatry
    C Barbui
    Laboratory of Epidemiology and Social Psychiatry, WHO Collaborating Centre for Research and Training in Mental Health, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Pharmacoepidemiol Drug Saf 10:647-52. 2001
    ..These notes aim at analysing current methods, ethical issues and major legislation changes related to drug epidemiology in Italy...
  97. ncbi request reprint Clinical trials of new antipsychotics: a critical appraisal
    C Barbui
    Laboratory of Epidemiology and Social Psychiatry, WHO Collaborating Centre for Research and Training in Mental Health, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Int Clin Psychopharmacol 14:133-7. 1999
    ..The final goal is the implementation of a new generation of trials with the aim of demonstrating superiority of effect of the new antipsychotic over the reference one...
  98. ncbi request reprint The Qualyop Project. 1: Monitoring the dismantlement of Italian public psychiatric hospitals. Characteristics of patients scheduled for discharge
    B D'Avanzo
    Laboratorio di Epidemiologia e Psichiatria Sociale, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Int J Soc Psychiatry 45:79-92. 1999
    ....
  99. ncbi request reprint Psychotropic drug use in Italy, 1984-99: the impact of a change in reimbursement status
    C Barbui
    Laboratory of Epidemiology and Social Psychiatry, WHO Collaborating Centre for Research and Training in Mental Health, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Int Clin Psychopharmacol 16:227-33. 2001
    ..This analysis highlights specific areas of concern which should become the object of public health programs...