Alberto Ballestrero

Summary

Affiliation: University of Genoa
Country: Italy

Publications

  1. ncbi request reprint Patient-tailored treatments with anti-EGFR monoclonal antibodies in advanced colorectal cancer: KRAS and beyond
    A Ballestrero
    Division of Semeiotics and Medical Methodology, Department of Internal Medicine, University of Genoa, Italy
    Curr Cancer Drug Targets 12:316-28. 2012
  2. pmc Effect of different cytokines on mammaglobin and maspin gene expression in normal leukocytes: possible relevance to the assays for the detection of micrometastatic breast cancer
    A Ballestrero
    Department of Internal Medicine, Universita di Genova, Viale Benedetto XV n 6, 16132 Genova, Italy
    Br J Cancer 92:1948-52. 2005
  3. ncbi request reprint Tumor necrosis factor-related apoptosis-inducing ligand cooperates with anticancer drugs to overcome chemoresistance in antiapoptotic Bcl-2 family members expressing jurkat cells
    Alberto Ballestrero
    Department of Internal Medicine, University of Genova, Genova, Italy
    Clin Cancer Res 10:1463-70. 2004
  4. ncbi request reprint Dose-dense vinorelbine and paclitaxel with granulocyte colony-stimulating factor in metastatic breast cancer patients: anti-tumor activity and peripheral blood progenitor cell mobilization capability
    Alberto Ballestrero
    Dipartimento di Medicina Interna, Universita di Genova, Genova, Italy
    Breast Cancer Res Treat 82:185-90. 2003
  5. doi request reprint Peripheral blood vs. bone marrow for molecular monitoring of BCR-ABL1 levels in chronic myelogenous leukemia, a retrospective analysis in allogeneic bone marrow recipients
    A Ballestrero
    Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, Genoa, Italy
    Int J Lab Hematol 32:387-91. 2010
  6. ncbi request reprint Pegfilgrastim compared with filgrastim after autologous peripheral blood stem cell transplantation in patients with solid tumours and lymphomas
    Alberto Ballestrero
    Dipartimento di Medicina Interna, Universita di Genova, Viale Benedetto XV 6, 16132, Genova, Italy
    Ann Hematol 87:49-55. 2008
  7. ncbi request reprint Ras-induced resistance to lapatinib is overcome by MEK inhibition
    Gabriele Zoppoli
    Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy
    Curr Cancer Drug Targets 10:168-75. 2010
  8. ncbi request reprint Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase
    Paolo Spallarossa
    Research Center of Cardiovascular Biology, Department of Cardiology, University of Genova, Viale Benedetto XV, 6 16132 Genova, Italy
    Cardiovasc Res 69:736-45. 2006
  9. doi request reprint Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells
    Gabriele Zoppoli
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Exp Hematol 38:979-88. 2010
  10. ncbi request reprint Quantitative Real Time PCR assessment of hormonal receptors and HER2 status on fine-needle aspiration pre-operatory specimens from a prospectively accrued cohort of women with suspect breast malignant lesions
    Anna Garuti
    Department of Internal Medicine, Istituto di Ricerca a Carattere Clinico e Scientifico IRCCS, Azienda Ospedaliera Universitaria AOU San Martino Istituto Nazionale Tumori IST, Genoa, Italy
    Gynecol Oncol 132:389-96. 2014

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Patient-tailored treatments with anti-EGFR monoclonal antibodies in advanced colorectal cancer: KRAS and beyond
    A Ballestrero
    Division of Semeiotics and Medical Methodology, Department of Internal Medicine, University of Genoa, Italy
    Curr Cancer Drug Targets 12:316-28. 2012
    ..Experimental topics and fields of ongoing research, such as targeting microRNAs (miRNAs) with novel anticancer drugs and epigenetics in CRC are also addressed...
  2. pmc Effect of different cytokines on mammaglobin and maspin gene expression in normal leukocytes: possible relevance to the assays for the detection of micrometastatic breast cancer
    A Ballestrero
    Department of Internal Medicine, Universita di Genova, Viale Benedetto XV n 6, 16132 Genova, Italy
    Br J Cancer 92:1948-52. 2005
    ..These results suggest that MAM is more specific than maspin and that the possible interference of cytokines should be taken into account in interpreting molecular assays for detection of isolated tumour cells...
  3. ncbi request reprint Tumor necrosis factor-related apoptosis-inducing ligand cooperates with anticancer drugs to overcome chemoresistance in antiapoptotic Bcl-2 family members expressing jurkat cells
    Alberto Ballestrero
    Department of Internal Medicine, University of Genova, Genova, Italy
    Clin Cancer Res 10:1463-70. 2004
    ..evaluated whether chemoresistance associated with Bcl-2 and Bcl-x(L) overexpression would be overcome by activating the death receptor pathway by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in the Jurkat cell model..
  4. ncbi request reprint Dose-dense vinorelbine and paclitaxel with granulocyte colony-stimulating factor in metastatic breast cancer patients: anti-tumor activity and peripheral blood progenitor cell mobilization capability
    Alberto Ballestrero
    Dipartimento di Medicina Interna, Universita di Genova, Genova, Italy
    Breast Cancer Res Treat 82:185-90. 2003
    ..4-36.5). Four cycles of dose dense VNB and PTX showed a favorable toxicity profile, a relevant anti-tumor activity and a high peripheral blood progenitor cell mobilizing activity...
  5. doi request reprint Peripheral blood vs. bone marrow for molecular monitoring of BCR-ABL1 levels in chronic myelogenous leukemia, a retrospective analysis in allogeneic bone marrow recipients
    A Ballestrero
    Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, Genoa, Italy
    Int J Lab Hematol 32:387-91. 2010
    ..3% of cases, and thus may be used to monitor the disease. This may be relevant when discussing both quality of life issues and the need for post-transplant monitoring with the patient...
  6. ncbi request reprint Pegfilgrastim compared with filgrastim after autologous peripheral blood stem cell transplantation in patients with solid tumours and lymphomas
    Alberto Ballestrero
    Dipartimento di Medicina Interna, Universita di Genova, Viale Benedetto XV 6, 16132, Genova, Italy
    Ann Hematol 87:49-55. 2008
    ..In conclusion, a single injection of pegfilgrastim administered at day +5 post-transplantation shows comparable safety and efficacy profiles to daily injections of filgrastim and may be cost effective...
  7. ncbi request reprint Ras-induced resistance to lapatinib is overcome by MEK inhibition
    Gabriele Zoppoli
    Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy
    Curr Cancer Drug Targets 10:168-75. 2010
    ..Combining MEK inhibitors with lapatinib may help overcome this form of resistance and increase the efficacy of lapatinib in these tumors...
  8. ncbi request reprint Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase
    Paolo Spallarossa
    Research Center of Cardiovascular Biology, Department of Cardiology, University of Genova, Viale Benedetto XV, 6 16132 Genova, Italy
    Cardiovasc Res 69:736-45. 2006
    ..Doxorubicin is a strongly cardiotoxic anticancer drug. This study investigates the effects of doxorubicin on myocardial MMP-2 and MMP-9 activation...
  9. doi request reprint Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells
    Gabriele Zoppoli
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Exp Hematol 38:979-88. 2010
    ..Here we have explored the interaction between APO866 and TRAIL in leukemia cell lines and in primary B-cell chronic lymphocytic leukemia cells...
  10. ncbi request reprint Quantitative Real Time PCR assessment of hormonal receptors and HER2 status on fine-needle aspiration pre-operatory specimens from a prospectively accrued cohort of women with suspect breast malignant lesions
    Anna Garuti
    Department of Internal Medicine, Istituto di Ricerca a Carattere Clinico e Scientifico IRCCS, Azienda Ospedaliera Universitaria AOU San Martino Istituto Nazionale Tumori IST, Genoa, Italy
    Gynecol Oncol 132:389-96. 2014
    ..Furthermore, current methods are not the ideal approach for reproducing the biological continuum of ER, PR, and HER2 receptor levels, due to their intrinsic, semi-quantitative nature, relying in part on subjective interpretation...
  11. pmc Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells
    Michele Cea
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    PLoS ONE 6:e22739. 2011
    ..In conclusion, NAD(+)-independent HDACs and sirtuins cooperate in leukemia cells to avoid apoptosis. Combining sirtuin with HDAC inhibitors results in synergistic antileukemic activity that could be therapeutically exploited...
  12. ncbi request reprint The proteasome and its inhibitors in immune regulation and immune disorders
    Alessio Nencioni
    Department of Internal Medicine, University of Genova, 16132 Genova, Italy
    Crit Rev Immunol 26:487-98. 2006
    ..The present review offers an overview of the mechanisms implicated in the immunomodulatory effects of proteasome inhibitors and discusses prospective future applications for these small molecules in immune and inflammatory diseases...
  13. ncbi request reprint The use of dendritic cells in cancer immunotherapy
    Alessio Nencioni
    Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy
    Crit Rev Oncol Hematol 65:191-9. 2008
    ..These issues are discussed here together with an overview of the DC-based antitumor immunotherapy studies...
  14. ncbi request reprint Three-step high-dose sequential chemotherapy in patients with newly diagnosed multiple myeloma
    Alberto Ballestrero
    Department of Internal Medicine, University of Genova, Italy
    Eur J Haematol 68:101-6. 2002
    ..However, there is no plateau in the survival curves, and experiments with new treatment schedules and conditioning regimens are warranted...
  15. doi request reprint A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia
    Gabriella Cirmena
    Department of Hematology, University of Genoa, V le Benedetto XV 6, 16132 Genoa, Italy
    Cancer Genet Cytogenet 183:105-8. 2008
    ..Previously, BCR-JAK2 rearrangement was observed in a single case with atypical chronic myelogenous leukemia (CML), but in that case the breakpoint in the BCR was different...
  16. pmc Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression
    Alessio Nencioni
    Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
    PLoS ONE 5:e9024. 2010
    ..In conclusion, Grb7 upregulation is a potentially adverse consequence of HER2 signaling inhibition. Preventing Grb7 accumulation and/or its interaction with receptor tyrosine kinases may increase the benefit of HER2-targeting drugs...
  17. ncbi request reprint Proteasome inhibitor bortezomib modulates TLR4-induced dendritic cell activation
    Alessio Nencioni
    Department of Internal Medicine, University of Genoa, Italy
    Blood 108:551-8. 2006
    ..These compounds could prove useful for tuning TLR signaling and for the treatment of inflammatory and immune-mediated disorders...
  18. doi request reprint Kinase domain mutations of BCR-ABL identified at diagnosis before imatinib-based therapy are associated with progression in patients with high Sokal risk chronic phase chronic myeloid leukemia
    Angelo M Carella
    Department of Hematology, Azienda Ospedaliera Universitaria San Martino, L go R Benzi 10, 16132 Genova, Italy
    Leuk Lymphoma 51:275-8. 2010
    ..No low-risk patient carried KD mutation at diagnosis. In conclusion, KD mutations conferring high-level imatinib resistance are present in patients with de novo CML and in some of them lead to disease progression...
  19. pmc The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses
    Inga Bauer
    Department of Internal Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research CEBR, University of Genoa, 16132 Genoa, Italy
    J Biol Chem 287:40924-37. 2012
    ..SIRT6 inhibition may help combat cancer-induced inflammation, angiogenesis, and metastasis...
  20. ncbi request reprint Histone deacetylase inhibitors affect dendritic cell differentiation and immunogenicity
    Alessio Nencioni
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Clin Cancer Res 13:3933-41. 2007
    ..Here, we have evaluated the effects of two HDAC inhibitors currently in clinical use, sodium valproate and MS-275, on human monocyte-derived DCs...
  21. pmc Rejuvenating sirtuins: the rise of a new family of cancer drug targets
    Santina Bruzzone
    Room 221, Department of Internal Medicine, University of Genoa, V le Benedetto XV 6, 16132 Genoa, Italy
    Curr Pharm Des 19:614-23. 2013
    ..Here, we review the biological rationale for the search of sirtuin inhibitors and activators for treating cancer and the experimental approaches to their identification...
  22. doi request reprint Proteasome inhibitors as immunosuppressants: biological rationale and clinical experience
    Eva Moran
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Semin Hematol 49:270-6. 2012
    ..Here, we discuss the biological rationale for the use of proteasome inhibitors as immunosuppressive agents and review the clinical experience with bortezomib in immune-mediated diseases...
  23. ncbi request reprint Proteasome inhibitor-induced apoptosis in human monocyte-derived dendritic cells
    Alessio Nencioni
    Department of Internal Medicine, University of Genova, Genova, Italy
    Eur J Immunol 36:681-9. 2006
    ..In conclusion, induction of apoptosis in DC may represent a novel mechanism by which proteasome inhibitors affect the immune response at the antigen-presenting cell level...
  24. doi request reprint Reliability and reproducibility of a RNA preamplification method for low-density array analysis from formalin-fixed paraffin-embedded breast cancer samples
    Paola Ciotti
    Department of Neuroscience, Ophthalmology, and Genetics, Section of Medical Genetics, University of Genova, Genova, Italy
    Diagn Mol Pathol 18:112-8. 2009
    ....
  25. pmc Low percentage of KRAS mutations revealed by locked nucleic acid polymerase chain reaction: implications for treatment of metastatic colorectal cancer
    Mariella Dono
    Molecular Diagnostic Division, Istituto di Ricovero e Cura a Carattere Scientitifico Azienda Ospedaliera Universitaria San Martino, Genova, Italy
    Mol Med 18:1519-26. 2012
    ..Failure to respond to these biological treatments occurred even in the absence of mutations in other EGFR pathway components such as BRAF...
  26. ncbi request reprint Immunotherapy with dendritic cells for cancer
    Alberto Ballestrero
    Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy
    Adv Drug Deliv Rev 60:173-83. 2008
    ..Here, we discuss these new insights together with an overview of the dendritic cell-based clinical studies carried out to date...
  27. ncbi request reprint Dendritic cells transfected with tumor RNA for the induction of antitumor CTL in colorectal cancer
    Alessio Nencioni
    Department of Internal Medicine, University of Genova, Genoa, Italy
    Cancer Gene Ther 10:209-14. 2003
    ....
  28. doi request reprint Bi-weekly docetaxel and gemcitabine regimen in her-2-negative and anthracycline-pretreated metastatic breast cancer patients: a multicenter phase II trial
    R Murialdo
    Department of Internal Medicine, S Martino Hospital, Viale Benedetto XV 6, 16132, Genoa, Italy
    Cancer Chemother Pharmacol 68:1009-16. 2011
    ..In the present phase II study, we investigated the activity of the same regimen as first-line treatment...
  29. pmc Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE
    Santina Bruzzone
    Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Genoa, Italy
    PLoS ONE 4:e7897. 2009
    ..In conclusion, Nampt inhibitors (and possibly Sirt6 inhibitors) could be used to modulate T cell-mediated immune responses and thereby be beneficial in immune-mediated disorders...
  30. doi request reprint Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice
    Alessio Nencioni
    Dr Alessio Nencioni, MD, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy, Tel 39 010 353 8990, Fax 39 010 353 8945, E mail
    Thromb Haemost 111:308-22. 2014
    ..These results support further assessments of NAMPT inhibitors for the potential prevention of plaque vulnerability...
  31. ncbi request reprint Nicotinamide phosphoribosyltransferase as a target in inflammation- related disorders
    Fabrizio Montecucco
    Room 221, Department of Internal Medicine, University of Genoa, V le Benedetto XV 6, 16132 Genoa, Italy
    Curr Top Med Chem 13:2930-8. 2013
    ..Overall, NAMPT inhibition holds potential for the treatment of inflammation-related disorders and the development of effective and safe NAMPT inhibitors remains an area of strong interest in pharmaceutical research...
  32. ncbi request reprint Carvedilol prevents doxorubicin-induced free radical release and apoptosis in cardiomyocytes in vitro
    Paolo Spallarossa
    Laboratory of Cardiovascular Biology, Division of Cardiology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6 Genova 16132, Italy
    J Mol Cell Cardiol 37:837-46. 2004
    ..Our results suggest that carvedilol is potentially protective against doxorubicin cardiotoxicity by decreasing free radical release and apoptosis in cardiomyocytes...
  33. ncbi request reprint Autologous peripheral blood stem cells (PBSC) in breast cancer
    Franco Patrone
    Clinica di Medicina Interna I, DIMI, University of Genova and San Martino Hospital, Italy
    Transfus Apher Sci 27:167-73. 2002
  34. ncbi request reprint Dynamic simulations of pathways downstream of ERBB-family, including mutations and treatments: concordance with experimental results
    N Castagnino
    Department of Internal Medicine, University of Genoa, Genova, Italy
    Curr Cancer Drug Targets 10:737-57. 2010
    ....
  35. ncbi request reprint Complex chromosome rearrangements may locate the bcr/abl fusion gene sites other than 22q11
    M Sessarego
    Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, 16132 Genoa, Italy
    Haematologica 85:35-9. 2000
    ..We studied two apparently Ph negative CML patients with unusual karyotypes both showing a typical b3a2 rearrangement...
  36. pmc High-dose mitoxantrone with peripheral blood progenitor cell rescue: toxicity, pharmacokinetics and implications for dosage and schedule
    A Ballestrero
    Dipartimento di Medicina Interna, , Genoa, Italy
    Br J Cancer 76:797-804. 1997
    ..It is concluded that, when adequately supported with PBPCs, NOV can be escalated up to 90 mg m(-2) with acceptable haematological toxicity. PBPCs can be safely reinfused as early as 96 h after NOV administration...
  37. ncbi request reprint High-dose chemotherapy with tandem autologous transplantation as part of the initial therapy for aggressive non-Hodgkin's lymphoma
    A Ballestrero
    Dipartimento di Medicina Interna, Universita di Genova, I 16132 Genova, Italy
    Int J Oncol 17:1007-13. 2000
    ..In A-AIPI group 1 the 2-year OS and FFS rates are both 91%...
  38. ncbi request reprint Reverse-transcriptase polymerase chain reaction of the maspin gene in the detection of bone marrow breast carcinoma cell contamination
    A Ballestrero
    Dipartimento di Medicina Interna, , Genova, Italy
    Cancer 92:2030-5. 2001
    ....
  39. pmc The effect of preoperative chemoradiotherapy on lymph nodes harvested in TME for rectal cancer
    Stefano Scabini
    Oncologic Surgery and Implantable Systems Unit, Department of Emergency, IRCCS San Martino IST, Genoa, Italy
    World J Surg Oncol 11:292. 2013
    ..This retrospective analysis single center study evaluated the effect of neoadjuvant chemoradiation on the number of lymph nodes in rectal carcinoma, considering some clinicopathological parameters...
  40. ncbi request reprint HMGA2 overexpression in polycythemia vera with t(12;21)(q14;q22)
    Stefania Aliano
    Laboratory of Cytogenetics, Department of Internal Medicine, University of Genoa, V le Benedetto XV 6, 16132 Genoa, Italy
    Cancer Genet Cytogenet 177:115-9. 2007
    ..Such overexpression may contribute to the pathogenesis of the disease, which otherwise of itself shows a favorable and stable course...
  41. ncbi request reprint Adjuvant chemotherapy with high-dose cyclophosphamide, etoposide and cisplatin intensification without progenitor cell support in breast cancer patients with ten or more involved nodes: 5-year results of a pilot trial
    A Ballestrero
    Department of Internal Medicine, Intensive Chemo-Immunotherapy Unit, University of Genoa, Genoa, Italy
    Oncology 60:221-7. 2001
    ..Although this regimen does not require stem cell harvesting and storage, it requires clinical support comparable to autotransplantation procedures and side effects are not so manageable to recommend its use outside specialized units...
  42. doi request reprint Germline mutations in the von Hippel-Lindau gene in Italian patients
    Paola Ciotti
    Department of Neuroscience, Ophthalmology, and Genetics Section of Medical Genetics, University of Genova and the Unit of Medical Genetics, Azienda Ospedaliera Universitaria San Martino of Genova, Viale Benedetto XV 6, Genova, Italy
    Eur J Med Genet 52:311-4. 2009
    ..In addition, an RQ-PCR protocol was validated in order to introduce it in the routine VHL laboratory diagnosis...
  43. ncbi request reprint Gemcitabine and carboplatin treatment in advanced NSCLC: a retrospective evaluation including elderly patients
    Roberto Murialdo
    Department of Internal Medicine, S Martino Hospital, Genoa, Italy
    Tumori 95:36-42. 2009
    ..Carboplatin-containing regimens are sometimes preferred for patients with advanced non-small cell lung cancer...
  44. ncbi request reprint The induction of distinct cytokine cascades correlates with different effects of granulocyte-colony stimulating factor and granulocyte/macrophage-colony-stimulating factor on the lymphocyte compartment in the course of high-dose chemotherapy for breast ca
    M Setti
    Department of Internal Medicine, University of Genoa, Viale Benedetto XV degrees 6, I 16132 Genoa, Italy
    Cancer Immunol Immunother 48:287-96. 1999
    ..The distinct pattern of the cytokine cascade induced by each factor, consistent with the different functional changes, seemed to account for the peculiarities of their immune modulations...
  45. ncbi request reprint Proteasome inhibitors: antitumor effects and beyond
    A Nencioni
    Department of Internal Medicine, University of Genova, Genova, Italy
    Leukemia 21:30-6. 2007
    ....
  46. ncbi request reprint Molecular diagnosis and monitoring of chronic myelogenous leukemia: BCR-Abl and more
    M Cea
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    J BUON 14:565-73. 2009
    ..These issues are discussed here together with an overview on how patients treated with tyrosine kinase inhibitors should be monitored...
  47. ncbi request reprint Cooperative cytotoxicity of proteasome inhibitors and tumor necrosis factor-related apoptosis-inducing ligand in chemoresistant Bcl-2-overexpressing cells
    Alessio Nencioni
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Clin Cancer Res 11:4259-65. 2005
    ..Here, we evaluated whether Bcl-2 overexpression affects the cytotoxic activity of proteasome inhibitors taken alone or in association with conventional anticancer drugs or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)...
  48. ncbi request reprint Reduced intensity conditioning for allograft after cytoreductive autograft in metastatic breast cancer
    Angelo M Carella
    Division of Haematology, Azienda Ospedaliera e Cliniche Universitarie San Martino, Largo R Benzi, 16132 Genoa, Italy
    Lancet 366:318-20. 2005
    ..No non-relapse-related deaths occurred during the first 100 days. Five patients (29%) were alive 90-2160 days (median 1320) after RICT. This two-step approach is feasible in patients with metastatic breast cancer...
  49. ncbi request reprint Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis
    Alessio Nencioni
    Massachusetts Institute of Technology, Department of Biology, Center for Cancer Research, Cambridge, MA, USA
    Blood 105:3255-62. 2005
    ..Pharmacologic or genetic approaches targeting Mcl-1, including therapeutic RNAi, may increase the effectiveness of these compounds...