C T Baldari

Summary

Affiliation: University of Siena
Country: Italy

Publications

  1. ncbi request reprint Antigen receptor signaling: the Tuscan chronicles
    Cosima T Baldari
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Nat Immunol 6:3-5. 2005
  2. pmc Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling
    Silvia Rossi Paccani
    Department of Evolutionary Biology, Policlinico Le Scotte, University of Siena, 53100 Siena, Italy
    J Exp Med 201:325-31. 2005
  3. pmc The Bordetella pertussis adenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapse
    Silvia Rossi Paccani
    Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy
    J Exp Med 208:1317-30. 2011
  4. pmc Negative regulation of chemokine receptor signaling and B-cell chemotaxis by p66Shc
    L Patrussi
    Department of Life Sciences, University of Siena, Siena, Italy
    Cell Death Dis 5:e1068. 2014
  5. ncbi request reprint Immune subversion by Helicobacter pylori
    Cosima T Baldari
    Department of Evolutionary Biology, University of Siena, Via A Moro 2, I 53100 Siena, Italy
    Trends Immunol 26:199-207. 2005
  6. ncbi request reprint T lymphocytes as targets of statins: molecular mechanisms and therapeutic perspectives
    Raffaella Ghittoni
    Department of Evolutionary Biology, University of Siena, Siena, Italy
    Inflamm Allergy Drug Targets 6:3-16. 2007
  7. ncbi request reprint Antigen receptor signaling under the Tuscan sun
    Cosima T Baldari
    Department of Evolutionary Biology, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Nat Immunol 3:1053-5. 2002
  8. doi request reprint Lymphocyte signaling in the Tuscan hills
    Cosima T Baldari
    Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy
    Immunity 31:692-5. 2009
  9. ncbi request reprint Antigen receptor signaling: the Tuscan connection
    Cosima T Baldari
    Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy
    Nat Immunol 8:787-90. 2007
  10. pmc Intraflagellar transport: it's not just for cilia anymore
    Cosima T Baldari
    Department of Molecular, Cellular and Developmental Biology, 310 Kline Biology Tower, PO Box 208103, Yale University, New Haven, CT 06520 8103, United States
    Curr Opin Cell Biol 22:75-80. 2010

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Antigen receptor signaling: the Tuscan chronicles
    Cosima T Baldari
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Nat Immunol 6:3-5. 2005
  2. pmc Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling
    Silvia Rossi Paccani
    Department of Evolutionary Biology, Policlinico Le Scotte, University of Siena, 53100 Siena, Italy
    J Exp Med 201:325-31. 2005
    ..These data identify a novel strategy of immune evasion by B. anthracis, based on both effector subunits of the toxic complex, and targeted to a key cellular component of adaptive immunity...
  3. pmc The Bordetella pertussis adenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapse
    Silvia Rossi Paccani
    Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy
    J Exp Med 208:1317-30. 2011
    ..The data also provide novel insights into the role of cAMP/PKA signaling in controlling the dynamics of the IS...
  4. pmc Negative regulation of chemokine receptor signaling and B-cell chemotaxis by p66Shc
    L Patrussi
    Department of Life Sciences, University of Siena, Siena, Italy
    Cell Death Dis 5:e1068. 2014
    ..The results identify p66Shc as a negative regulator of B-cell chemotaxis and suggest a role for this adaptor in the control of B-cell homing. ..
  5. ncbi request reprint Immune subversion by Helicobacter pylori
    Cosima T Baldari
    Department of Evolutionary Biology, University of Siena, Via A Moro 2, I 53100 Siena, Italy
    Trends Immunol 26:199-207. 2005
    ..Several mechanisms and the bacterial factors involved in immune subversion have, in recent years, been elucidated, thus opening the possibility of a better understanding of the pathogenicity of this microorganism...
  6. ncbi request reprint T lymphocytes as targets of statins: molecular mechanisms and therapeutic perspectives
    Raffaella Ghittoni
    Department of Evolutionary Biology, University of Siena, Siena, Italy
    Inflamm Allergy Drug Targets 6:3-16. 2007
    ..The therapeutic perspectives of these findings, based on animal models and ongoing clinical trials, will also be discussed...
  7. ncbi request reprint Antigen receptor signaling under the Tuscan sun
    Cosima T Baldari
    Department of Evolutionary Biology, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Nat Immunol 3:1053-5. 2002
  8. doi request reprint Lymphocyte signaling in the Tuscan hills
    Cosima T Baldari
    Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy
    Immunity 31:692-5. 2009
    ..Its graceful structure and quiet surroundings provided a perfect setting for an informal, cooperative discussion of an impressive body of new largely unpublished data. Here, we summarize the principal findings...
  9. ncbi request reprint Antigen receptor signaling: the Tuscan connection
    Cosima T Baldari
    Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy
    Nat Immunol 8:787-90. 2007
  10. pmc Intraflagellar transport: it's not just for cilia anymore
    Cosima T Baldari
    Department of Molecular, Cellular and Developmental Biology, 310 Kline Biology Tower, PO Box 208103, Yale University, New Haven, CT 06520 8103, United States
    Curr Opin Cell Biol 22:75-80. 2010
    ..It is proposed that the cilium, in addition to being a sensory and motile organelle, is also a secretory organelle...
  11. pmc T cell targeting by anthrax toxins: two faces of the same coin
    Silvia Rossi Paccani
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Toxins (Basel) 3:660-71. 2011
    ....
  12. ncbi request reprint Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation
    S Pacini
    Department of Evolutionary Biology, University of Siena, Via Mattioli 4, 53100 Siena, Italy
    J Biol Chem 273:20487-93. 1998
    ..The data show that Tyr474 on ZAP-70 is required for TCR signaling and suggest that Shc association with ZAP-70 and the resulting phosphorylation of Shc might be an obligatory step in linking the activated TCR to the Ras pathway...
  13. ncbi request reprint Validation of a diagnostic score for the diagnosis of autoinflammatory diseases in adults
    Luca Cantarini
    Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, University of Siena, Italy
    Int J Immunopathol Pharmacol 24:695-702. 2011
    ....
  14. ncbi request reprint Identification and characterization of a novel nuclear factor of activated T-cells-1 isoform expressed in mouse brain
    S Plyte
    Departments of Evolutionary Biology and Molecular Biology, University of Siena, Italy
    J Biol Chem 276:14350-8. 2001
    ..NFAT1-D was, however, inducibly activated in a cyclosporin A-sensitive manner when expressed in T-cells, suggesting that the activity of NFAT proteins might be controlled by their specific cellular context...
  15. ncbi request reprint p66SHC promotes T cell apoptosis by inducing mitochondrial dysfunction and impaired Ca2+ homeostasis
    M Pellegrini
    Department of Evolutionary Biology, University of Siena, Siena I 53100, Italy
    Cell Death Differ 14:338-47. 2007
    ..Thus, Ca2+-dependent p66Shc phosphorylation causes both mitochondrial dysfunction and impaired Ca2+ homeostasis, which synergize in promoting T cell apoptosis...
  16. ncbi request reprint Sequences of two cDNA clones from the medfly Ceratitis capitata encoding antibacterial peptides of the cecropin family
    M Rosetto
    Department of Evolutionary Biology, Siena, Italy
    Gene 134:241-3. 1993
    ..Sequence determination shows that the cDNAs encode two closely related peptides which are members of the cecropin family...
  17. ncbi request reprint Development and preliminary validation of a diagnostic score for identifying patients affected with adult-onset autoinflammatory disorders
    L Cantarini
    Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Italy
    Int J Immunopathol Pharmacol 23:1133-41. 2010
    ..94). We have identified variables that appear to be strongly related to the probability of detecting gene mutations in MEF and TNFRSF1A in adults, thus improving the evaluation of patients with suspected autoinflammatory disorders...
  18. ncbi request reprint cDNA sequence and expression of the ceratotoxin gene encoding an antibacterial sex-specific peptide from the medfly Ceratitis capitata (diptera)
    D Marchini
    Department of Evolutionary Biology, University of Siena, Italy
    J Biol Chem 270:6199-204. 1995
    ..Western blot analysis using an anti-ceratotoxin antibody indicates the female accessory glands as the only site where the production of the ceratotoxin peptide occurs...
  19. pmc p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells
    Sonia Pacini
    Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy
    Mol Cell Biol 24:1747-57. 2004
    ..The data highlight a novel interplay between p66Shc and p52Shc in the control of T-cell fate...
  20. ncbi request reprint p66Shc is involved in promoting HIF-1alpha accumulation and cell death in hypoxic T cells
    Fabio Carraro
    Department of Physiology, University of Siena, Siena, Italy
    J Cell Physiol 211:439-47. 2007
    ..Thus, p66Shc may play an important role in downstream hypoxic signaling, involving HIF-1alpha protein accumulation and cell death in T lymphocytes...
  21. ncbi request reprint Defective signaling to Fyn by a T cell antigen receptor lacking the alpha -chain connecting peptide motif
    C Ulivieri
    Department of Evolutionary Biology, University of Siena, Via Mattioli 4, 53100 Siena, Italy
    J Biol Chem 276:3574-80. 2001
    ..Hence the signaling defect generated by the TCR alpha-CPM mutation results at least in part from an impaired coupling of the TCR.CD3 complex to Fyn activation...
  22. ncbi request reprint Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering
    M M Di Somma
    Department of Evolutionary Biology, University of Siena, Italy
    Eur J Immunol 26:2181-8. 1996
    ..A functional analysis of different CD4 epitopes using either anti-CD4 mAb or HIV-1 gp120 reveals a common epitope-specific activation of both the LTR and of the transcription factors NF-kappa B and NF-AT...
  23. ncbi request reprint Molecular mechanisms underlying suppression of lymphocyte responses by nonsteroidal antiinflammatory drugs
    S Rossi Paccani
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Cell Mol Life Sci 60:1071-83. 2003
    ....
  24. ncbi request reprint Restoration of thymic development in an Lck(-/-) thymoma overexpressing ZAP-70
    C Ulivieri
    Department of Evolutionary Biology, University of Siena, Via Mattioli 4, 53100, Siena, Italy
    Mol Immunol 37:85-90. 2000
    ..Hence ZAP-70 overexpression in thymocytes is associated with recovery from the developmental arrest caused by the absence of Lck, suggesting a role for ZAP-70 downstream of Lck in the maturation of CD4(+)CD8(+) thymocytes...
  25. ncbi request reprint Vav1 haploinsufficiency in a common variable immunodeficiency patient with defective T-cell function
    N Capitani
    Department of Evolutionary Biology, University of Siena, Italy
    Int J Immunopathol Pharmacol 25:811-7. 2012
    ..The disease-related pedigree of this patient suggests a de novo origin of the Vav1 deletion. The findings highlights Vav1 as an autosomal dominant disease gene associated with CVID with defective T-cell function...
  26. ncbi request reprint Intracellular mediators of CXCR4-dependent signaling in T cells
    Laura Patrussi
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Immunol Lett 115:75-82. 2008
    ..The aim of this review is to briefly summarize the current knowledge of the signaling machinery which controls the process of chemotaxis in CXCL12-stimulated T lymphocytes...
  27. doi request reprint Simvastatin impairs humoral and cell-mediated immunity in mice by inhibiting lymphocyte homing, T-cell activation and antigen cross-presentation
    Cristina Ulivieri
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, Siena, Italy
    Eur J Immunol 38:2832-44. 2008
    ..The data provide novel mechanistic insight into the activities of simvastatin in the highly complex context of the immune response...
  28. doi request reprint The adaptor protein p66Shc is a positive regulator in the angiogenic response induced by hypoxic T cells
    Antonella Naldini
    Department of Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    J Leukoc Biol 87:365-9. 2010
    ..In conclusion, hypoxic T cells may contribute to the onset of angiogenesis through a novel VEGF-mediated mechanism, where p66Shc acts as a positive regulator...
  29. ncbi request reprint Apoptosis and oxidative stress-related diseases: the p66Shc connection
    Michela Pellegrini
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Curr Mol Med 9:392-8. 2009
    ..In this review the multifaceted role of p66Shc in redox regulation will be discussed, with a focus on the mechanisms underlying p66Shc-dependent apoptosis and its role in oxidative stress-related diseases...
  30. ncbi request reprint The thrombin peptide, TP508, enhances cytokine release and activates signaling events
    Antonella Naldini
    Department of Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    Peptides 25:1917-26. 2004
    ..These data support the hypothesis that TP508 may accelerate tissue repair through the activation of the inflammatory response...
  31. ncbi request reprint Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases
    Raffaella Ghittoni
    Department of Evolutionary Biology, University of Siena, Italy
    FASEB J 19:605-7. 2005
    ..The results identify Ras superfamily GTPases as strategic molecular targets in T-cell immunosuppression by statins...
  32. pmc The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms
    Marianna Boncristiano
    Department of Evolutionary Biology, University of Sienna, 53100 Siena, Italy
    J Exp Med 198:1887-97. 2003
    ..The resulting defects in T cell activation may help H. pylori to prevent an effective immune response leading to chronic colonization of its gastric niche...
  33. ncbi request reprint The BCR signalosome: where cell fate is decided
    C Ulivieri
    Department of Evolutionary Biology, University of Siena, Siena, Italy
    J Biol Regul Homeost Agents 19:1-16. 2005
    ..Here we briefly review the current knowledge on the molecules which participate in the BCR signalosome and on the response modulators which control the final signal output by enhancing or dampening BCR signaling...
  34. ncbi request reprint p66SHC: the apoptotic side of Shc proteins
    M Pellegrini
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy
    Apoptosis 10:13-8. 2005
    ..Specifically, we focus on the 66 kDa isoform of ShcA, whose paramount importance in the regulation of oxidative stress responses leading to cell apoptosis and ageing has been by now firmly established...
  35. pmc Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussis
    Silvia Rossi Paccani
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Infect Immun 76:2822-32. 2008
    ....
  36. ncbi request reprint F-actin dynamics control segregation of the TCR signaling cascade to clustered lipid rafts
    Silvia Valensin
    Laboratory of Molecular Biology, Department of Evolutionary Biology, University of Siena, Siena, Italy
    Eur J Immunol 32:435-46. 2002
    ....
  37. ncbi request reprint Expression in T-cells of the proapoptotic protein p66SHC is controlled by promoter demethylation
    Alfredo Pezzicoli
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Biochem Biophys Res Commun 349:322-8. 2006
    ..Our data underline the role of CpG methylation in the control of p66Shc gene expression and provide evidence that Ca2+ signaling may lead to epigenetic modifications in nondividing cells...
  38. ncbi request reprint Glycerophosphoinositol-4-phosphate enhances SDF-1alpha-stimulated T-cell chemotaxis through PTK-dependent activation of Vav
    Laura Patrussi
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy
    Cell Signal 19:2351-60. 2007
    ..Collectively, the data provide the first evidence of a role of glycerophosphoinositols as modulators of T-cell signaling and establish a mechanistic basis for the effects of this phosphoinositide derivative on F-actin dynamics...
  39. ncbi request reprint Nonsteroidal anti-inflammatory drugs suppress T-cell activation by inhibiting p38 MAPK induction
    Silvia Rossi Paccani
    Department of Evolutionary Biology, University of Siena, Via Mattioli 4, 53100 Siena, Italy
    J Biol Chem 277:1509-13. 2002
    ..The data identify COX-1 and COX-2 as integral and sequential components of TCR signaling to p38 and contribute to elucidate the molecular basis of immunosuppression by NSAID...
  40. ncbi request reprint Idiopathic recurrent pericarditis refractory to colchicine treatment can reveal tumor necrosis factor receptor-associated periodic syndrome
    L Cantarini
    Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy
    Int J Immunopathol Pharmacol 22:1051-8. 2009
    ..A poor response to colchicine treatment and/or a steroid-dependence may be the clue to investigate TNFRSF1A mutations in patients with idiopathic recurrent pericarditis...
  41. ncbi request reprint The potential of peroxisome proliferator-activated receptor gamma (PPARgamma) ligands in the treatment of hematological malignancies
    C Ulivieri
    Department of Evolutionary Biology, Via Aldo Moro 2, 53100 Siena, Italy
    Mini Rev Med Chem 7:877-87. 2007
    ..Here we shall review the activities of PPARgamma ligands in the control of immune cell proliferation, differentiation and apoptosis and their potential therapeutic applications to hematological malignancies...
  42. doi request reprint Opposite effects of simvastatin on the bactericidal and inflammatory response of macrophages to opsonized S. aureus
    Daniela Benati
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    J Leukoc Biol 87:433-42. 2010
    ..The results provide novel mechanistic insight into the activities of statins on phagocytes and are of relevance to the assessment of potential side-effects in patients undergoing long-term hypocholesterolemic therapy...
  43. pmc The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling
    Silvia Rossi Paccani
    Department of Evolutionary Biology, University of Siena, Siena, Italy
    PLoS Pathog 5:e1000325. 2009
    ..Furthermore, our results strongly support the key role of cAMP in the adjuvanticity of these toxins...
  44. ncbi request reprint Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases
    Raffaella Ghittoni
    Department of Evolutionary Biology, University of Siena, Siena, Italy
    Eur J Immunol 36:2885-93. 2006
    ..In addition, simvastatin was found to preferentially affect the invariant chain-dependent MHC class II pathway, thereby identifying this route of antigen processing and presentation as a selective target of statins...
  45. doi request reprint The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity
    Francesca Finetti
    Department of Evolutionary Biology, University of Siena, Siena, Italy
    Blood 111:5017-27. 2008
    ..The data identify p66Shc as a negative regulator of lymphocyte activation and show that loss of this protein results in breaking of immunologic tolerance and development of systemic autoimmunity...
  46. ncbi request reprint Cytoskeleton rearrangement induced by tetraspanin engagement modulates the activation of T and NK cells
    Stefania Crotta
    Chiron Vaccines, Siena, Italy
    Eur J Immunol 36:919-29. 2006
    ..We propose that tetraspanin engagement leads to comparable cytoskeleton reorganization in T and NK cells, which in turn results in opposite functional outcomes...
  47. ncbi request reprint T cell costimulation by the hepatitis C virus envelope protein E2 binding to CD81 is mediated by Lck
    Elisabetta Soldaini
    IRIS Research Center, Chiron, Siena, Italy
    Eur J Immunol 33:455-64. 2003
    ..In conclusion, we propose that the costimulatory effects of HCV E2 on T cells depend on CD81 cross-linking that activates Lck through raft aggregation and thus leads to enhanced TCR signaling...
  48. ncbi request reprint Anthrax toxins inhibit immune cell chemotaxis by perturbing chemokine receptor signalling
    Silvia Rossi Paccani
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Cell Microbiol 9:924-9. 2007
    ..The data highlight a novel strategy of immunosuppression by B. anthracis based on inhibition of immune cell homing...
  49. ncbi request reprint Normal B-1 cell development but defective BCR signaling in Lck-/- mice
    Cristina Ulivieri
    Department of Evolutionary Biology, University of Siena, Siena, Italy
    Eur J Immunol 33:441-5. 2003
    ..The data suggest a potential role for Lck in the achievement of the higher activation threshold required for productive BCR signaling in B-1 as compared to B-2 cells...
  50. pmc Extensive temporally regulated reorganization of the lipid raft proteome following T-cell antigen receptor triggering
    Luca Bini
    Department of Molecular Biology, University of Siena, Via Fiorentina 1, 53100 Siena, Italy
    Biochem J 369:301-9. 2003
    ....
  51. ncbi request reprint Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival
    Laura Patrussi
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, Siena 53100, Italy
    Oncogene 24:2218-28. 2005
    ..The data underline a pleiotropic and nonredundant role of Shc, mediated by both YY239/240 and Y317, in T-cell activation and survival...
  52. ncbi request reprint The CXCL12/CXCR4 axis as a therapeutic target in cancer and HIV-1 infection
    L Patrussi
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Itlay
    Curr Med Chem 18:497-512. 2011
    ....
  53. ncbi request reprint The Bcl-2 family as a rational target for the treatment of B-cell chronic lymphocytic leukaemia
    N Capitani
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, Siena, Italy
    Curr Med Chem 17:801-11. 2010
    ....
  54. ncbi request reprint The aminoterminal phosphotyrosine binding domain of Shc associates with ZAP-70 and mediates TCR dependent gene activation
    E Milia
    IRIS, Siena, Italy
    Oncogene 13:767-75. 1996
    ..A significant inhibition of NF-AT activation by TCR triggering was observed, showing a functional involvement of She in TCR signaling through its PTB domain and suggesting an important role for She association with ZAP-70...
  55. ncbi request reprint The genes encoding the antibacterial sex-specific peptides ceratotoxins are clustered in the genome of the medfly Ceratitis capitata
    M Rosetto
    Department of Evolutionary Biology, University of Siena, Italy
    Insect Biochem Mol Biol 27:1039-46. 1997
    ..The presence of highly conserved motifs in the upstream regions of all the sequenced ceratotoxin genes suggests the presence of common regulatory elements for all ceratotoxins...
  56. doi request reprint Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia
    Nagaja Capitani
    Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy
    Blood 115:3726-36. 2010
    ..They moreover provide evidence that the p66Shc expression defect in CLL B cells may be causal to the imbalance toward the antiapoptotic Bcl-2 family members in these cells...
  57. doi request reprint Positive and negative regulation of antigen receptor signaling by the Shc family of protein adapters
    Francesca Finetti
    Department of Evolutionary Biology, University of Siena, Siena, Italy
    Immunol Rev 232:115-34. 2009
    ..These developments reveal an unexpected and complex interplay of multiple Shc proteins in lymphocytes...
  58. pmc Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse
    Francesca Finetti
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Nat Cell Biol 11:1332-9. 2009
    ....
  59. ncbi request reprint Nonsteroidal anti-inflammatory drugs inhibit a Fyn-dependent pathway coupled to Rac and stress kinase activation in TCR signaling
    Silvia Rossi Paccani
    Department of Evolutionary Biology, University of Siena, Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Blood 105:2042-8. 2005
    ..The data identify COX-1 as an important early modulator of TCR signaling and highlight a TCR proximal pathway selectively coupling the TCR to stress kinase activation...
  60. ncbi request reprint Defective Vav expression and impaired F-actin reorganization in a subset of patients with common variable immunodeficiency characterized by T-cell defects
    Silvia Rossi Paccani
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Blood 106:626-34. 2005
    ..The actin cytoskeleton defect could be reversed by reconstitution of Vav1 expression in the patients' T cells. Results demonstrate an essential role of Vav in human T cells and strongly suggest Vav insufficiency in T-CVID...
  61. ncbi request reprint Anthrax toxins: A paradigm of bacterial immune suppression
    Cosima T Baldari
    Department of Evolutionary Biology, University of Siena, 53100, Siena, Italy
    Trends Immunol 27:434-40. 2006
    ..anthracis-specific responses. Thus, B. anthracis can invade the host, with ensuing massive bacteremia and toxemia. Here, we review the specific effects of B. anthracis on neutrophils, macrophages, dendritic cells, T- and B-lymphocytes...
  62. ncbi request reprint Conditional up-regulation of IL-2 production by p38 MAPK inactivation is mediated by increased Erk1/2 activity
    Olga Kogkopoulou
    Department of Pathophysiology, School of Medicine, University of Athens, Greece
    J Leukoc Biol 79:1052-60. 2006
    ..Also, the finding that p38 acts in a strength-of-stimulation-dependent way provides an explanation for previously reported, contradictory results regarding the role of this kinase in IL-2 expression...
  63. ncbi request reprint p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells
    Laura Patrussi
    Departments of Evolutionary Biology, European Institute of Oncology, Milan, Italy
    Blood 110:1730-8. 2007
    ....
  64. ncbi request reprint Inhibition of ShcA isoforms p46/p52Shc enhances HIV-1 replication in CD4+ T-lymphocytes
    Luca Benetti
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Microbiology and Virology, University of Padua, Padua, Italy
    J Cell Physiol 199:40-6. 2004
    ..The data presented suggest that ShcA proteins can play a role in committing CD4(+) T-cells to apoptosis, as a response to HIV-1 infection...
  65. pmc T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions
    Marisa Benagiano
    Department of Internal Medicine, University of Florence, Viale Morgagni, Italy
    Proc Natl Acad Sci U S A 100:6658-63. 2003
    ..Plaque-derived Th1 cells expressed cytotoxicity, proapoptotic activity, and help for monocyte tissue factor production. Although multifactorial, atherosclerosis can be regarded as a Th1-driven immunopathological condition...
  66. ncbi request reprint Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors
    Zamal Ahmed
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    J Mol Biol 353:1001-10. 2005
    ..The difference in the spatio-temporal localization of these proteins following stimulation may eliminate signal crosstalk, and could explain the differentiation of the specific downstream responses of these pathways...
  67. pmc The Vibrio cholerae cytolysin promotes activation of mast cell (T helper 2) cytokine production
    Diletta Arcidiacono
    Department of Biomedical Sciences, University of Padua, Via G Colombo 3, 35121 Padua, Italy
    Cell Microbiol 10:899-907. 2008
    ..These findings strongly suggest that VCC has a pro-inflammatory activity promoting a Th2-type immune profile...