Research Topics
Genomes and GenesSpecies | A BaccarelliSummaryAffiliation: University of Milan Country: Italy Publications
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Publications
Effects of particulate air pollution on blood pressure in a highly exposed population in Beijing, China: a repeated-measure studyAndrea Baccarelli
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health 10:108. 2011..PM effects on blood pressure (BP) have been investigated as a mechanism mediating cardiovascular risks, but results are still inconsistent. The purpose of our study is to determine the effects of ambient and personal PM exposure on BP...- Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workersMirjam Hoxha
Center of Molecular and Genetic Epidemiology, Department of Preventive Medicine, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
Environ Health 8:41. 2009..Traffic pollution has been linked with both cardiovascular and cancer risks, particularly in older subjects. Whether exposure to traffic pollution is associated with telomere shortening has never been evaluated... - Airborne particulate matter and mitochondrial damage: a cross-sectional studyLifang Hou
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Environ Health 9:48. 2010..Although mitochondria are both the major intracellular source and target of oxidative stress, the effect of PM on mitochondria has never been evaluated in exposed individuals... 
Handling of dioxin measurement data in the presence of non-detectable values: overview of available methods and their application in the Seveso chloracne studyAndrea Baccarelli
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Bethesda, MD 20852, USA
Chemosphere 60:898-906. 2005..6% of plasma TCDD measurements were non-detects. We suggest that distribution-based multiple imputation be the preferred method to analyze environmental data when substantial proportions of observations are non-detects...- Rapid DNA methylation changes after exposure to traffic particlesAndrea Baccarelli
Laboratory of Environmental Epigenetics, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, 20122 Milan, Italy
Am J Respir Crit Care Med 179:572-8. 2009..Lower blood DNA methylation content is found in processes related to cardiovascular outcomes, such as oxidative stress, aging, and atherosclerosis... - Risk of lung cancer and exposure to industrial acids, solvents, and metals in leningrad province, RussiaAndrea Baccarelli
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
J Occup Environ Med 48:48-55. 2006..We sought to investigate the association of occupational exposure to industrial acids, solvents, and metals with lung cancer in Leningrad Province, Russia, where an excess of occupationally related lung cancer was reported recently... - Living near major traffic roads and risk of deep vein thrombosisAndrea Baccarelli
EPOCA Research Center for Environmental and Occupational Epidemiology, Department of Environmental and Occupational Health, Via San Barnaba 8, 20122 Milan, Italy
Circulation 119:3118-24. 2009..We investigated whether living near major traffic roads increases the risk of deep vein thrombosis (DVT), using distance from roads as a proxy for traffic exposure... - Epigenetics and environmental chemicalsAndrea Baccarelli
Laboratory of Environmental Epigenetics, Center of Molecular and Genetic Epidemiology, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, Milan, Italy
Curr Opin Pediatr 21:243-51. 2009..Here, we review current evidence indicating that epigenetic alterations mediate toxicity from environmental chemicals... - Risk of lung cancer from exposure to dusts and fibers in Leningrad Province, RussiaAndrea Baccarelli
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
Am J Ind Med 49:460-7. 2006..Exposures to several dusts and fibers (DFs) have been established or suggested as etiologic factors for lung cancer... - Occupational and environmental agents as endocrine disruptors: experimental and human evidenceA Baccarelli
Institute of Endocrine Sciences, Ospedale Maggiore, IRCCS, and EPOCA Research Center for Occupational, Clinical and Environmental Epidemiology, University of Milan, Italy
J Endocrinol Invest 23:771-81. 2000..This paper reviews the experimental and human evidence of the effects of occupational and environmental chemical agents on hypothalamus-pituitary unit, pineal gland, parathyroid and calcium metabolism and adrenal glands... 
Analysis of the 206M polymorphic variant of the SLC26A6 gene encoding a Cl- oxalate transporter in patients with primary hyperparathyroidismS Corbetta
Endocrinology and Diabetology Unit, Department of Medical Surgical Sciences, University of Milan, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Milan, Italy
Eur J Endocrinol 160:283-8. 2009..Hypercalciuria and urine oxalate excretion are considered risk factors for urolithiasis in PHPT as well as in idiopathic stone-formers. Recently, the anion-exchanger SLC26A6 has been involved in the oxalate metabolism...- Occupation and lung cancer risk in Leningrad Province, RussiaA Baccarelli
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Med Lav 96:142-54. 2005.... - Health status and plasma dioxin levels in chloracne cases 20 years after the Seveso, Italy accidentA Baccarelli
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Behtesda, MD 20892-7236, USA
Br J Dermatol 152:459-65. 2005..Chloracne occurrence appeared related to younger age and light hair colour. Age-related dioxin elimination or dilution must be taken into account in interpreting these results... - Combined risk factors for melanoma in a Mediterranean populationM T Landi
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Bethesda, MD 20892 7236, USA
Br J Cancer 85:1304-10. 2001.... - Global DNA methylation and low-level exposure to benzeneSilvia Fustinoni
Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
Med Lav 103:84-95. 2012..Whether global genomic DNA methylation content is reduced in response to benzene exposure is still undetermined... - Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women's Health StudyY Gao
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
Br J Cancer 106:585-91. 2012..Recent data suggest a link between blood leukocyte DNA methylation, and cancer risk. However, reports on DNA methylation from a prospective study are unavailable for gastric cancer... - Health effects of dioxin exposure: a 20-year mortality studyP A Bertazzi
EPOCA, Research Center for Occupational, Clinical and Environmental Epidemiology, Department of Occupational and Environmental Health, University of Milan, Milan, Italy
Am J Epidemiol 153:1031-44. 2001..Results support evaluation of dioxin as carcinogenic to humans and corroborate the hypotheses of its association with other health outcomes, including cardiovascular- and endocrine-related effects... - DNA methylation in repetitive elements and Alzheimer diseaseV Bollati
Center of Molecular and Genetic Epidemiology, Department of Environmental and Occupational Health, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
Brain Behav Immun 25:1078-83. 2011..Further prospective investigations are warranted to evaluate the dynamics of DNA methylation from early-stage AD to advanced phases of the disease... - Environmental epigeneticsV Bollati
Department of Environmental and Occupational Health, Center of Molecular and Genetic Epidemiology, Università degli Studi di Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
Heredity (Edinb) 105:105-12. 2010.... - Polymorphisms in Th1-type cell-mediated response genes and risk of gastric cancerL Hou
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8123, Bethesda, MD 20852 7242, USA
Carcinogenesis 28:118-23. 2007..IL1A (-889 C>T) and the three examined IL12A variants were unrelated to gastric cancer risk. Our findings suggest that two Th1-related polymorphisms (TNFA -308 A>G and IFNGR2 Ex7-128 C>T) may increase the risk of gastric cancer... - Comparison between six-year therapy with long-acting somatostatin analogs and successful surgery in acromegaly: effects on cardiovascular risk factorsCristina L Ronchi
Institute of Endocrine Sciences, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, 20122 Milan, Italy
J Clin Endocrinol Metab 91:121-8. 2006..The effects of chronic therapy with long-acting somatostatin analogs (SSTa) on metabolic and cardiovascular parameters have been partially elucidated in acromegalic patients... - Changes in DNA methylation patterns in subjects exposed to low-dose benzeneValentina Bollati
Molecular Epidemiology Laboratory, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, 20122 Milan, Italy
Cancer Res 67:876-80. 2007..20). This is the first human study to link altered DNA methylation, reproducing the aberrant epigenetic patterns found in malignant cells, to low-level carcinogen exposure... - Immunologic effects of dioxin: new results from Seveso and comparison with other studiesAndrea Baccarelli
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Environ Health Perspect 110:1169-73. 2002..The possible long-term immunologic effects of TCDD exhibited by the participants of the present study, coupled with the increased incidence of lymphatic tumors in the area of the accident, warrant further investigation... - Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic InuitJennifer A Rusiecki
Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
Environ Health Perspect 116:1547-52. 2008..DNA methylation, an epigenetic mechanism, has been associated with cancer initiation and progression. Greenlandic Inuit have some of the highest reported POP levels worldwide... - TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accidentMaria Teresa Landi
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
Carcinogenesis 24:673-80. 2003.... - Differential repetitive DNA methylation in multiple myeloma molecular subgroupsValentina Bollati
Center of Molecular and Genetic Epidemiology, EPOCA, Epidemiology Research Center, Università degli Studi di Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, 20122 Milan, Italy
Carcinogenesis 30:1330-5. 2009..001). Our results indicate that global hypomethylation of repetitive elements is significantly associated with tumor progression in MM and may contribute toward a more extensive stratification of the disease... - CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenomaLifang Hou
Department of Human and Health Services, Division of Cancer Epidemiology and Genetics, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
Carcinogenesis 26:1122-8. 2005..002). In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions... - Risk of renal cell carcinoma in relation to blood telomere length in a population-based case-control studyJ N Hofmann
Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892 7240, USA
Br J Cancer 105:1772-5. 2011..There are few known risk factors for renal cell carcinoma (RCC). Two small hospital-based case-control studies suggested an association between short blood telomere length (TL) and increased RCC risk... - XPD gene polymorphism and host characteristics in the association with cutaneous malignant melanoma riskA Baccarelli
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, 6120 Executive Blvd, Bethesda, MD 20892 7236, USA
Br J Cancer 90:497-502. 2004..DNA repair capacity was slightly decreased in subjects carrying 751Gln alleles. XPD variants may modify melanoma risk in subjects with specific host characteristics, such as older age, lack of dysplastic naevi or low tanning ability... - Risk factors associated to kidney stones in primary hyperparathyroidismS Corbetta
Institute of Endocrine Sciences, Fondazione Ospedale Maggiore IRCCS, University of Milan, Milan, Italy
J Endocrinol Invest 28:122-8. 2005..In conclusion, hypercalciuria, higher oxalate excretion and severe PHPT are associated with kidney stones in PHPT... - CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, ItalyMaria Teresa Landi
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS, Bethesda, MD 20892 7236, USA
Toxicology 207:191-202. 2005..Genetic variation in cytochrome P450 induction may identify subjects with variable responsiveness to TCDD and potentially increased risk of disease... - Aryl hydrocarbon receptor-interacting protein and pituitary adenomas: a population-based study on subjects exposed to dioxin after the Seveso, Italy, accidentAngela Cecilia Pesatori
Department of Occupational and Environmental Health, EPOCA Research Center, Clinica L Devoto, University of Milan, Via San Barnaba 8, 20122 Milano, Italy
Eur J Endocrinol 159:699-703. 2008..AIP is a chaperone protein with multifunction properties, including modulation of the transcriptional activity of the aryl hydrocarbon receptor, which mediates toxicological and carcinogenic dioxin effects... - Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish populationRajeev Mahajan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Jpn J Clin Oncol 38:626-33. 2008..7-1.3) for C/T and 0.6 (95% CI, 0.3-1.0) T/T carriers compared with C/C carriers (P = 0.03). These results suggest that IL5 rs2069812 and IL7R rs1389832, rs1494556 and rs1494555 polymorphisms may contribute to gastric cancer etiology... - Aryl-hydrocarbon receptor-dependent pathway and toxic effects of TCDD in humans: a population-based study in Seveso, ItalyAndrea Baccarelli
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
Toxicol Lett 149:287-93. 2004..Markers within the AhR pathway were correlated with one another. Our findings suggest the presence of long-term effects in the subjects exposed to TCDD after the Seveso accident... - Exposure to metal-rich particulate matter modifies the expression of candidate microRNAs in peripheral blood leukocytesValentina Bollati
Department of Environmental and Occupational Health, Università degli Studi di Milano and IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico, Center of Molecular and Genetic Epidemiology, Milan, Italy
Environ Health Perspect 118:763-8. 2010..MicroRNAs (miRNAs) are highly conserved, noncoding small RNAs that regulate the expression of broad gene networks at the posttranscriptional level... - Short- and long-term morbidity and mortality in the population exposed to dioxin after the "Seveso accident"Angela Cecilia Pesatori
Department of Occupational and Environmental Medicine and EPOCA Epidemiology Research Center, , Milan, Italy
Ind Health 41:127-38. 2003..The mortality and cancer incidence follow-up of the Seveso cohort are continuing... - [Risk factors of malignant skin melanoma in Italian population: review of results of a case-control study]Andrea Baccarelli
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH 6120 Executive Blvd, EPS 7110, Bethesda, MD 20892 7236, USA
Epidemiol Prev 26:293-9. 2002..7; 95% CI: 2.4-18.6) than those lacking dysplastic nevi and with high DRC. These results may help identify high-risk subjects in the Mediterranean populations who would the benefit from preventive measures... - Development and validation of a gas chromatography/mass spectrometry method for the assessment of genomic DNA methylationFederica Rossella
Department of Occupational and Environmental Medicine, University of Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8, 20122 Milan, Italy
Rapid Commun Mass Spectrom 23:2637-46. 2009..05%), DNA from peripheral blood leukocytes of healthy subjects (N = 6, median methylation 5.45%), DNA from bone marrow of leukemia patients (N = 5, 3.58%) and DNA from myeloma cell lines (N = 4, 2.74%)... - DNA repair, dysplastic nevi, and sunlight sensitivity in the development of cutaneous malignant melanomaMaria Teresa Landi
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
J Natl Cancer Inst 94:94-101. 2002..We designed this case-control study to determine whether DNA repair capacity (DRC) is associated with the risk of CMM and to identify risk factors that may interact biologically with DRC in the development of melanoma... - Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylationLetizia Tarantini
Laboratory of Environmental Epigenetics, Department of Preventive Medicine, University of Milan and IRCCS Maggiore Hospital, Milan, Italy
Environ Health Perspect 117:217-22. 2009..Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined... - Decline in genomic DNA methylation through aging in a cohort of elderly subjectsValentina Bollati
Center of Molecular and Genetic Epidemiology, Department of Environmental and Occupational Health, University of Milan and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
Mech Ageing Dev 130:234-9. 2009..089 %5mC/year, p<0.0001). In contrast, average LINE-1 methylation did not vary over time [p=0.51]. Our results demonstrate a progressive loss of DNA methylation in repetitive elements dispersed throughout the genome... - Mannose-binding lectin-2 genetic variation and stomach cancer riskAndrea Baccarelli
EPOCA Epidemiology Research Centre, Maggiore Hospital IRCCS Foundation, University of Milan, Milan, Italy
Int J Cancer 119:1970-5. 2006..5, 95% CI 1.6-7.6; p = 0.001). Our findings suggest that the codon 52 D MBL2 variant causing a cysteine > arginine replacement, but not B and C variants producing glycine substitutions, is specifically associated with gastric cancer risk... - t(14;18) translocations in lymphocytes of healthy dioxin-exposed individuals from Seveso, ItalyAndrea Baccarelli
EPOCA Research Center for Occupational, Clinical and Environmental Epidemiology, Department of Occupational and Environmental Health, University of Milan, IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milan, Italy
Carcinogenesis 27:2001-7. 2006..Whether this change in t(14;18) frequency is an indicator of elevated lymphoma risk remains speculative and needs further investigation for its potential impact on public health... - Cis sequence effects on gene expressionAndrew W Bergen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA
BMC Genomics 8:296. 2007.... - Correspondence re: K. Toide et al., Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells: trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins. 12: 219Maria Teresa Landi
Cancer Epidemiol Biomarkers Prev 12:1116-7; author reply 1118. 2003 - Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjectsCliona M McHale
School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Toxicology 229:101-13. 2007..Further examination of the role of these genes in dioxin induced-toxicity is warranted... - Exposure to particulate air pollution and risk of deep vein thrombosisAndrea Baccarelli
Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Arch Intern Med 168:920-7. 2008..Particulate air pollution has been linked to heart disease and stroke, possibly resulting from enhanced coagulation and arterial thrombosis. Whether particulate air pollution exposure is related to venous thrombosis is unknown... - Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogenKyle Steenland
Rollins School of Public Health, Emory University, Atlanta, Georgia 30306, USA
Environ Health Perspect 112:1265-8. 2004..There are also new data regarding how the AhR functions in mediating the carcinogenic response to TCDD. The new evidence generally supports the 1997 IARC classification... - Pesticide exposure and lung cancer mortality in Leningrad province in RussiaWon Jin Lee
Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea
Environ Int 32:412-6. 2006..Our findings suggest no associations between pesticide exposures and mortality of lung cancer in the population of the Leningrad province in Russia that deserves further evaluation... - Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphismsAndrea Baccarelli
Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA
Circulation 117:1802-9. 2008.... - COX1 and COX2 polymorphisms and gastric cancer risk in a Polish populationLifang Hou
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Drive, Chicago, IL 60611, USA
Anticancer Res 27:4243-7. 2007..Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied... - Metals and neurotoxicologyRobert O Wright
Department of Pediatrics, Children s Hospital, Boston Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
J Nutr 137:2809-13. 2007..Parallel work in metals demonstrates that epigenetics may be a critical pathway by which metals produce health effects... - Neonatal thyroid function in Seveso 25 years after maternal exposure to dioxinAndrea Baccarelli
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS Med 5:e161. 2008.... - Air pollution, smoking, and plasma homocysteineAndrea Baccarelli
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 115:176-81. 2007..Air pollution exposure induces short-term inflammatory changes that may determine hyperhomocysteinemia, particularly in the presence of a preexisting proinflammatory status such as that found in cigarette smokers...