Angelo Avogaro

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi request reprint [Diabetes and multimetabolic syndrome]
    Angelo Avogaro
    Cattedra di Malattie del Metabolismo, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi, Via Giustiniani, 2 35128 Padova
    Ital Heart J 4:13S-21S. 2003
  2. ncbi request reprint Dipeptidyl-peptidase 4 Inhibition: Linking Metabolic Control to Cardiovascular Protection
    Angelo Avogaro
    Cattedra di Malattie del Metabolismo, Dipartimento di Medicina Universita di Padova, Via Giustiniani, 2, 35128 Padova Italia
    Curr Pharm Des 20:2387-94. 2014
  3. ncbi request reprint Ectopic calcification in diabetic vascular disease
    Angelo Avogaro
    University of Padova, Department of Medicine, Endocrinology and Metabolism, Via Giustiniani, 2, 35100 Padova, Italy 39 049 8212178 39 049 8212184
    Expert Opin Ther Targets 18:595-609. 2014
  4. ncbi request reprint Cardiovascular actions of GLP-1 and incretin-based pharmacotherapy
    Angelo Avogaro
    Malattie del Metabolismo, Dipartimento di Medicina DIMED, Universita di Padova, Via Giustiniani, 2, 35120, Padova, Italy
    Curr Diab Rep 14:483. 2014
  5. doi request reprint Achieving glycemic control in patients with type 2 diabetes and renal impairment
    Angelo Avogaro
    Department of Medicine, School of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy
    Acta Diabetol 50:283-91. 2013
  6. doi request reprint [Cardioprotective effects of glucagon-like peptide-1: preclinical and clinical data]
    Angelo Avogaro
    Cattedra di Malattie del, Dipartimento di Medicina, Universita degli Studi, Padova
    G Ital Cardiol (Rome) 12:17-24. 2011
  7. ncbi request reprint Which is the eligible patient to be treated with pioglitazone? The expert view
    A Avogaro
    Department of Clinical and Experimental Medicine, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    J Endocrinol Invest 34:781-7. 2011
  8. pmc Characterizing multisegment foot kinematics during gait in diabetic foot patients
    Zimi Sawacha
    Department of Information Engineering, University of Padova, Padova, Italy
    J Neuroeng Rehabil 6:37. 2009
  9. pmc Monitoring the occurrence of diabetes mellitus and its major complications: the combined use of different administrative databases
    Stefano Brocco
    Epidemiological Department, Veneto Region, Italy
    Cardiovasc Diabetol 6:5. 2007
  10. doi request reprint Treating diabetes today with gliclazide MR: a matter of numbers
    A Avogaro
    Department of Clinical and Experimental Medicine, University of Padova, Venetian Institute of Molecular Medicine, Padova, Italy
    Diabetes Obes Metab 14:14-9. 2012

Detail Information

Publications131 found, 100 shown here

  1. ncbi request reprint [Diabetes and multimetabolic syndrome]
    Angelo Avogaro
    Cattedra di Malattie del Metabolismo, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi, Via Giustiniani, 2 35128 Padova
    Ital Heart J 4:13S-21S. 2003
    ..Yet, despite a normal LDL cholesterol level, patients with this syndrome are at high risk for future cardiovascular events: for this reason treatment with statins is mandatory...
  2. ncbi request reprint Dipeptidyl-peptidase 4 Inhibition: Linking Metabolic Control to Cardiovascular Protection
    Angelo Avogaro
    Cattedra di Malattie del Metabolismo, Dipartimento di Medicina Universita di Padova, Via Giustiniani, 2, 35128 Padova Italia
    Curr Pharm Des 20:2387-94. 2014
    ..Clinical trials aimed to demonstrate the efficacy of DPP4 inhibitors in reducing cardiovascular events, independent of their anti-hyperglycemic action, are ongoing. These trials will also give necessary information on their safety. ..
  3. ncbi request reprint Ectopic calcification in diabetic vascular disease
    Angelo Avogaro
    University of Padova, Department of Medicine, Endocrinology and Metabolism, Via Giustiniani, 2, 35100 Padova, Italy 39 049 8212178 39 049 8212184
    Expert Opin Ther Targets 18:595-609. 2014
    ..In diabetic patients, vascular calcifications are more frequently observed than in people without diabetes. In particular, elevated degrees of coronary artery and valvular calcifications are reported in populations with diabetes...
  4. ncbi request reprint Cardiovascular actions of GLP-1 and incretin-based pharmacotherapy
    Angelo Avogaro
    Malattie del Metabolismo, Dipartimento di Medicina DIMED, Universita di Padova, Via Giustiniani, 2, 35120, Padova, Italy
    Curr Diab Rep 14:483. 2014
    ..The first clinical trials aimed to demonstrate the safety of DPP4 inhibitors have been recently published: their clinical significance will be discussed in light of the prior experimental findings. ..
  5. doi request reprint Achieving glycemic control in patients with type 2 diabetes and renal impairment
    Angelo Avogaro
    Department of Medicine, School of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy
    Acta Diabetol 50:283-91. 2013
    ..However, further studies with larger populations of patients with type 2 diabetes and chronic kidney disease are needed to clarify the efficacy and safety of the different treatment options, including newer drugs...
  6. doi request reprint [Cardioprotective effects of glucagon-like peptide-1: preclinical and clinical data]
    Angelo Avogaro
    Cattedra di Malattie del, Dipartimento di Medicina, Universita degli Studi, Padova
    G Ital Cardiol (Rome) 12:17-24. 2011
    ..These mechanisms of action will be discussed in detail in this article...
  7. ncbi request reprint Which is the eligible patient to be treated with pioglitazone? The expert view
    A Avogaro
    Department of Clinical and Experimental Medicine, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    J Endocrinol Invest 34:781-7. 2011
    ..Attention should be given to possible side effects relating to class effects of TZD, and selection of appropriate patients to be prescribed pioglitazone will enable optimum benefits to be derived from pioglitazone treatment...
  8. pmc Characterizing multisegment foot kinematics during gait in diabetic foot patients
    Zimi Sawacha
    Department of Information Engineering, University of Padova, Padova, Italy
    J Neuroeng Rehabil 6:37. 2009
    ..Most of gait analysis protocols represent the entire foot as a rigid body connected to the shank. Nevertheless the existing multisegment models cannot completely decipher the impairments associated with the diabetic foot...
  9. pmc Monitoring the occurrence of diabetes mellitus and its major complications: the combined use of different administrative databases
    Stefano Brocco
    Epidemiological Department, Veneto Region, Italy
    Cardiovasc Diabetol 6:5. 2007
    ..Administrative databases offer relevant opportunities for this purpose. We aim to monitor the incidence of diabetes and its major complications using administrative data...
  10. doi request reprint Treating diabetes today with gliclazide MR: a matter of numbers
    A Avogaro
    Department of Clinical and Experimental Medicine, University of Padova, Venetian Institute of Molecular Medicine, Padova, Italy
    Diabetes Obes Metab 14:14-9. 2012
    ....
  11. ncbi request reprint Mechanisms of endothelial dysfunction in obesity
    Angelo Avogaro
    Metabolic Diseases Department of Clinical and Experimental Medicine, University of Padova, School of Medicine, Via Giustiniani 2, 35128 Padova, Italy
    Clin Chim Acta 360:9-26. 2005
    ..The possible pathogenetic links between obesity and cardiovascular disease, mediated by oxidative stress, inflammation and endothelial dysfunction are described as well...
  12. ncbi request reprint Endothelial dysfunction in type 2 diabetes mellitus
    Angelo Avogaro
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Via Giustiniani 2, 35128 Padova, Italy
    Nutr Metab Cardiovasc Dis 16:S39-45. 2006
    ..The aim of the present study is to illustrate possible mechanisms responsible for endothelial dysfunction in DM...
  13. ncbi request reprint Insulin resistance: trigger or concomitant factor in the metabolic syndrome
    A Avogaro
    Unit of Metabolic Diseases, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Panminerva Med 48:3-12. 2006
    ....
  14. ncbi request reprint Acute alcohol consumption improves insulin action without affecting insulin secretion in type 2 diabetic subjects
    Angelo Avogaro
    Dipartimento Medicina Sperimentale Policlinico, University of Padua Medical School, Via Giustiniani 2, 35128 Padua, Italy
    Diabetes Care 27:1369-74. 2004
    ..The aim of the present study was to assess the role of acute moderate alcohol intake on insulin sensitivity and insulin secretion in comparable subjects with and without type 2 diabetes...
  15. ncbi request reprint The under-use of statin in type 2 diabetic patients attending diabetic clinics in Italy
    Angelo Avogaro
    Department of Clinical and Experimental Medicine, University of Padova, School of Medicine, Via Giustiniani 2, 35128 Padova, Italy
    Nutr Metab Cardiovasc Dis 17:32-40. 2007
    ..Our aims were to: (1) assess the prevalence of statin use in patients attending diabetic clinics and (2) correlate the use of statins with their risk and clinical status...
  16. ncbi request reprint Diabetic cardiomyopathy: a metabolic perspective
    Angelo Avogaro
    Division of Metabolic Diseases, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Am J Cardiol 93:13A-16A. 2004
    ....
  17. ncbi request reprint Moderate alcohol consumption, glucose metabolism and lipolysis: the effect on adiponectin and tumor necrosis factor alpha
    A Avogaro
    Division of Metabolic Diseases, University of Padua Medical School, Padua, Italy
    J Endocrinol Invest 26:1213-8. 2003
    ..Further studies are needed to clarify the antilipolytic effect of moderate alcohol intake...
  18. ncbi request reprint Gemfibrozil improves insulin sensitivity and flow-mediated vasodilatation in type 2 diabetic patients
    A Avogaro
    University of Padova, Padova, Italy, LADSEB CNR, Padova, Italy, Parke Davis Italia, Lainate, Milan, Italy
    Eur J Clin Invest 31:603-9. 2001
    ..Endothelial dysfunction is an early feature of atherosclerosis. The relationship between insulin action and hypertriglyceridaemia on endothelial function is still debated...
  19. doi request reprint Insulin signaling and life span
    Angelo Avogaro
    Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    Pflugers Arch 459:301-14. 2010
    ....
  20. ncbi request reprint Glucose tolerance during moderate alcohol intake: insights on insulin action from glucose/lactate dynamics
    Angelo Avogaro
    Department of Clinical and Experimental Medicine, University of Padova Medical School, 35128 Padova, Italy
    J Clin Endocrinol Metab 87:1233-8. 2002
    ..Because ETOH at moderate doses has a marked antilipolytic action, it might improve insulin action by improving substrate competition. The present findings suggest that moderate alcohol consumption in the diet should not be discouraged...
  21. ncbi request reprint L-arginine-nitric oxide kinetics in normal and type 2 diabetic subjects: a stable-labelled 15N arginine approach
    Angelo Avogaro
    Department of Metabolic Disease, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    Diabetes 52:795-802. 2003
    ..From our data, it appears that noncomplicated type 2 diabetic patients have a decreased conversion of arginine to NO...
  22. ncbi request reprint Monocyte NADPH oxidase subunit p22(phox) and inducible hemeoxygenase-1 gene expressions are increased in type II diabetic patients: relationship with oxidative stress
    Angelo Avogaro
    Department of Clinical and Experimental Medicine, University of Padova, School of Medicine, Italy
    J Clin Endocrinol Metab 88:1753-9. 2003
    ..These findings suggest that these cells, which play a crucial role in the earliest events of atherosclerotic lesion, are subjected to an increased oxidative stress...
  23. ncbi request reprint [Glucagon-like peptide-1: pleiotropic effects on the cardiovascular system]
    Angelo Avogaro
    Cattedra di Malattie del Metabolismo, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi, Padova
    G Ital Cardiol (Rome) 9:753-8. 2008
    ..It is known to affect the cardiovascular system by decreasing blood pressure, to improve the endothelial function, and to increase myocardial contractility. Such effects are discussed in depth in this article...
  24. doi request reprint Endothelial dysfunction: causes and consequences in patients with diabetes mellitus
    Angelo Avogaro
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Diabetes Res Clin Pract 82:S94-S101. 2008
    ....
  25. doi request reprint Oxidative stress and vascular disease in diabetes: is the dichotomization of insulin signaling still valid?
    Angelo Avogaro
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Free Radic Biol Med 44:1209-15. 2008
    ....
  26. ncbi request reprint Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism
    Giulio Ceolotto
    Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2 35128 Padova, Italy
    Arterioscler Thromb Vasc Biol 27:2627-33. 2007
    ..In this study, we tested the hypothesis that rosiglitazone (RSG) is able to quench oxidative stress initiated by high glucose through prevention of NAD(P)H oxidase activation...
  27. ncbi request reprint [Glucagon like peptide-1 and the cardiovascular system: pathophysiological mechanisms]
    Angelo Avogaro
    Cattedra di Malattie del Metabolismo, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi, Padova
    G Ital Cardiol (Rome) 11:18S-25S. 2010
    ..GLP-1 receptor agonists are able to reduce blood pressure, improve endothelial function, increase myocardial contractility. These effects will be discussed in detail in this article...
  28. ncbi request reprint Insulin generates free radicals in human fibroblasts ex vivo by a protein kinase C-dependent mechanism, which is inhibited by pravastatin
    Giulio Ceolotto
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Via Giustiniani 2, 35128 Padova, Italy
    Free Radic Biol Med 41:473-83. 2006
    ..Pravastatin inhibited radical oxygen species production by inhibiting PKC delta. These observations offer a robust explanation for the positive effects of pravastatin treatment in patients with insulin resistance syndrome...
  29. doi request reprint Low CD34+ cell count and metabolic syndrome synergistically increase the risk of adverse outcomes
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Atherosclerosis 207:213-9. 2009
    ..Circulating progenitor cells have been shown to contribute to endothelial homeostasis and repair . We aimed to test whether progenitor cell count is an independent event predictor and modifies cardiovascular risk associated with MetS...
  30. pmc Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms
    Saula Vigili de Kreutzenberg
    Department of Clinical and Experimental Medicine, Metabolic Diseases, University of Padova, Padova, Italy
    Diabetes 59:1006-15. 2010
    ..We also assessed the potential mechanisms linking metabolic alterations to SIRTs in human monocytes (THP-1) in vitro...
  31. ncbi request reprint Number and function of endothelial progenitor cells as a marker of severity for diabetic vasculopathy
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Italy
    Arterioscler Thromb Vasc Biol 26:2140-6. 2006
    ..This study aimed to establish whether number and function of EPCs correlate with PAD severity in type 2 diabetic patients...
  32. doi request reprint Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Padova, Italy
    Circ Res 108:1112-21. 2011
    ..Acquisition of a procalcific phenotype by resident or circulating cells is important for calcification of atherosclerotic plaques, which is common in diabetes...
  33. pmc Nitric oxide synthesis is reduced in subjects with type 2 diabetes and nephropathy
    Paolo Tessari
    Department of Clinical and Experimental Medicine, Metabolism Division, University of Padova, Italy
    Diabetes 59:2152-9. 2010
    ..However, whether the decreased NOx excretion in type 2 diabetes is caused by a defective NOx production from arginine in response to hyperinsulinemia has never been studied...
  34. pmc The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, School of Medicine, University of Padova, Padova, Italy
    Diabetes Care 33:1607-9. 2010
    ..Because SDF-1alpha is a substrate of dipeptidyl-peptidase-4 (DPP-4), we investigated whether the DPP-4 inhibitor sitagliptin modulates EPC levels in type 2 diabetic patients...
  35. ncbi request reprint Effects of different insulin regimes on postprandial myocardial perfusion defects in type 2 diabetic patients
    Roldano Scognamiglio
    Metabolic Cardiology, Division of Metabolic Diseases, Department of Clinical and Experimental Medicine, University of Padova Medical School, Padua, Italy
    Diabetes Care 29:95-100. 2006
    ..We examined the efficacy of two different insulin regimes (regular insulin and insulin analog) in controlling postprandial hyperglycemia and in preventing myocardial perfusion abnormalities...
  36. ncbi request reprint Abnormal myocardial perfusion and contractile recruitment during exercise in type 1 diabetic patients
    Roldano Scognamiglio
    Metabolic Cardiology Unit, Division of Metabolic Diseases, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Clin Cardiol 28:93-9. 2005
    ....
  37. doi request reprint Selective estrogen receptor-alpha agonist provides widespread heart and vascular protection with enhanced endothelial progenitor cell mobilization in the absence of uterotrophic action
    Chiara Bolego
    Department of Pharmacology and Anesthesiology, University of Padua, Largo Meneghetti 2, 35131 Padua, Italy
    FASEB J 24:2262-72. 2010
    ..By conferring cardiovascular protection dissected from unwanted uterotrophic effects, ER alpha-selective agonists may represent a potential safer alternative to natural hormones...
  38. doi request reprint Impaired hemodynamic response to meal intake in insulin-resistant subjects: an impedance cardiography approach
    Saula Vigili de Kreutzenberg
    Departments of Clinical and Experimental Medicine and Information Engineering, Padova University, Padova, Italy
    Am J Clin Nutr 93:926-33. 2011
    ..In the postprandial state, insulin regulates metabolic and cardiovascular responses. In insulin resistance, the insulin action is impaired at both levels. However, postprandial hemodynamic responses are poorly characterized in this setting...
  39. pmc Effects of androgens on endothelial progenitor cells in vitro and in vivo
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Clin Sci (Lond) 117:355-64. 2009
    ..In conclusion, our results collectively demonstrate that androgens exert no direct effects on endothelial progenitor cell biology in vitro and in vivo...
  40. pmc Time course and mechanisms of circulating progenitor cell reduction in the natural history of type 2 diabetes
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Diabetes Care 33:1097-102. 2010
    ..The present study was designed to describe the extent and potential mechanisms of progenitor cell reduction during the natural history of type 2 diabetes...
  41. doi request reprint Heme oxygenase-1 is an important modulator in limiting glucose-induced apoptosis in human umbilical vein endothelial cells
    Elisabetta Iori
    Department of Clinical and Experimental Medicine, University of Padua, School of Medicine, Via Giustiniani 2, 35128 Padova, Italy
    Life Sci 82:383-92. 2008
    ..Lack of homeostatic HO-1 upregulation fails to protect from oxidative damage and results in a higher rate of apoptotic cell death...
  42. doi request reprint Myeloid calcifying cells promote atherosclerotic calcification via paracrine activity and allograft inflammatory factor-1 overexpression
    Mattia Albiero
    Venetian Institute of Molecular Medicine, Padova, Italy
    Basic Res Cardiol 108:368. 2013
    ..In conclusion, we show that murine OC(+)BAP(+) cells correspond to human MCCs and promote atherosclerotic calcification in ApoE(-/-) mice, through paracrine activity and modulation of resident cells by AIF-1 overexpression. ..
  43. doi request reprint Integrated kinematics-kinetics-plantar pressure data analysis: a useful tool for characterizing diabetic foot biomechanics
    Zimi Sawacha
    Department of Information Engineering, University of Padova, Via Gradenigo 6b I, 35131 Padova, Italy
    Gait Posture 36:20-6. 2012
    ..05). Initial results showed that this methodology may enable a more appropriate characterization of patients at risk of foot ulcerations, and help planning prevention programs...
  44. pmc Procalcific phenotypic drift of circulating progenitor cells in type 2 diabetes with coronary artery disease
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, 35128 Padova, Italy
    Exp Diabetes Res 2012:921685. 2012
    ..In conclusion, circulating progenitor cells of diabetic patients show a phenotypic drift toward a pro-calcific phenotype that may be driven by inflammatory signals...
  45. ncbi request reprint Oral amino acids in elderly subjects: effect on myocardial function and walking capacity
    Roldano Scognamiglio
    Division of Metabolic Diseases, University of Padua, Padua, Italy
    Gerontology 51:302-8. 2005
    ..Objective: To assess the effects of administering oral AAs on walking capacity and perceived walking impairment, isometric muscular strength, and myocardial function at rest and during isometric exercise...
  46. doi request reprint Rosuvastatin stimulates clonogenic potential and anti-inflammatory properties of endothelial progenitor cells
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Cell Biol Int 34:709-15. 2010
    ..In conclusion, we show that rosuvastatin had significant stimulatory effects on EPCs irrespective of the culture protocol. Rosuvastatin also induced anti-inflammatory polarization of monocytic EPCs...
  47. pmc The transcriptional response in human umbilical vein endothelial cells exposed to insulin: a dynamic gene expression approach
    Barbara Di Camillo
    Information Engineering Department, University of Padova, Padova, Italy
    PLoS ONE 5:e14390. 2010
    ....
  48. ncbi request reprint Circulating CD34+ cells, metabolic syndrome, and cardiovascular risk
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padua, Medical School, Padua, Italy
    Eur Heart J 27:2247-55. 2006
    ..As general agreement on their characterization is lacking, this work was carried out to assess the relationships between different antigenic profiles of progenitor cells and CV risk, with special regard to metabolic syndrome (MetSyn)...
  49. ncbi request reprint Circulating progenitor cells are reduced in patients with severe lung disease
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova School of Medicine, Italy
    Stem Cells 24:1806-13. 2006
    ..This alteration was more evident in restrictive patients and correlated to disease severity. Depletion of circulating EPCs may be involved in altered endothelial homeostasis of pulmonary circulation in these disorders...
  50. doi request reprint Hemodynamics assessed via approximate entropy analysis of impedance cardiography time series: effect of metabolic syndrome
    Stefania Guerra
    Department of Information Engineering, University of Padova, Padova, Italy
    Am J Physiol Heart Circ Physiol 301:H592-8. 2011
    ..In conclusion, we identified that MS is characterized by an increased complexity of ICG signals: this may have a prognostic relevance in subjects with this condition...
  51. pmc The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Diabetes 59:2306-14. 2010
    ..Genetic deletion of p66Shc prolongs life span and protects against oxidative stress. In the present study, we evaluated the role of p66Shc in an animal model of diabetic wound healing...
  52. doi request reprint Impaired endothelial progenitor cell recruitment may contribute to heart transplant microvasculopathy
    Elena Osto
    Department of Cardiology, University of Padova, Padova, Italy
    J Heart Lung Transplant 30:70-6. 2011
    ..We assessed the relationship between circulating PCs and their incorporation into allografts and coronary microvascular function in HTx...
  53. ncbi request reprint Postprandial myocardial perfusion in healthy subjects and in type 2 diabetic patients
    Roldano Scognamiglio
    Metabolic Cardiology, Division of Metabolic Diseases, Department of Clinical and Experimental Medicine, University of Padova Medical School, Padua, Italy
    Circulation 112:179-84. 2005
    ..A negative influence of acute hyperglycemia on systemic endothelial function (brachial artery) has been shown. However, myocardial perfusion during postprandial hyperglycemia has not been investigated...
  54. doi request reprint Mechanisms and significance of progenitor cell reduction in the metabolic syndrome
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Metab Syndr Relat Disord 7:5-10. 2009
    ..We also highlight how endothelial progenitors may mediate the interactions between cardiometabolic risk factors in a complex interplay and discuss potential implications for prevention and therapy...
  55. doi request reprint Circulating myeloid calcifying cells have antiangiogenic activity via thrombospondin-1 overexpression
    Lisa Menegazzo
    2Department of Medicine, Division of Metabolic Diseases, University Hospital of Padova, Via Giustiniani 2, 35100 Padova, Italy
    FASEB J 27:4355-65. 2013
    ..The study highlights the successful identification and validation of a pathogenic pathway by a gold standard proteomic/transcriptomic analysis of blood cells...
  56. pmc Diabetes impairs stem cell and proangiogenic cell mobilization in humans
    Gian Paolo Fadini
    Department of Medicine, University of Padova, Padova, Italy
    Diabetes Care 36:943-9. 2013
    ..Herein, we sought to assay mobilization of stem and proangiogenic cells in subjects with and without DM...
  57. doi request reprint Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathy
    Gian Paolo Fadini
    Department of Medicine, University of Padova, Via Giustiniani, 2, 35100 Padua, Italy
    Basic Res Cardiol 108:313. 2013
    ..In conclusion, the analysis of stem cell compartmentalization in humans led us to discover mechanisms of BM unresponsiveness in diabetes determined by tissue-specific DPP-4 dysregulation...
  58. doi request reprint Arterio-venous gradients of endothelial progenitor cells reveal a complex kinetics in human limb ischemia
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Clin Hemorheol Microcirc 50:293-300. 2012
    ....
  59. pmc Closed-loop artificial pancreas using subcutaneous glucose sensing and insulin delivery and a model predictive control algorithm: preliminary studies in Padova and Montpellier
    Daniela Bruttomesso
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, Padova, Italy
    J Diabetes Sci Technol 3:1014-21. 2009
    ....
  60. doi request reprint Characteristics and outcomes of the hyperglycemic hyperosmolar non-ketotic syndrome in a cohort of 51 consecutive cases at a single center
    Gian Paolo Fadini
    Division of Metabolic Diseases, Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Diabetes Res Clin Pract 94:172-9. 2011
    ..The hyperglycemic hyperosmolar syndrome (HHS) is a life-threatening diabetic complication. We aimed to portrait the short and long term outcome after a HHS episode and to describe features associated with increased early mortality...
  61. ncbi request reprint Peripheral blood CD34+KDR+ endothelial progenitor cells are determinants of subclinical atherosclerosis in a middle-aged general population
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Stroke 37:2277-82. 2006
    ..With this background, we evaluated whether variations in the number of EPCs are associated with subclinical atherosclerosis in healthy subjects...
  62. doi request reprint Gender differences in endothelial progenitor cells and cardiovascular risk profile: the role of female estrogens
    Gian Paolo Fadini
    Clinical and Experimental Medicine, University of Padova Medical School, Italy
    Arterioscler Thromb Vasc Biol 28:997-1004. 2008
    ..Endothelial progenitor cells (EPCs) participate in vascular homeostasis and angiogenesis. The aim of the present study was to explore EPC number and function in relation to cardiovascular risk, gender, and reproductive state...
  63. ncbi request reprint Significance of endothelial progenitor cells in subjects with diabetes
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Diabetes Care 30:1305-13. 2007
  64. ncbi request reprint Endothelial progenitor cells and the diabetic paradox
    Gian Paolo Fadini
    Dipartimento di Medicina Clinica e Sperimentale, Divisione di Malattie del Metabolismo, Policlinico Universitario, Via Giustiniani 2, 35100 Padua, Italy
    Diabetes Care 29:714-6. 2006
  65. ncbi request reprint Metformin prevents glucose-induced protein kinase C-beta2 activation in human umbilical vein endothelial cells through an antioxidant mechanism
    Alessandra Gallo
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Diabetes 54:1123-31. 2005
    ..Our data substantiate the findings of previous large intervention studies on the beneficial effect of this drug in type 2 diabetic patients...
  66. pmc Glucose and fatty acid metabolism in a 3 tissue in-vitro model challenged with normo- and hyperglycaemia
    Elisabetta Iori
    Division of Metabolic Diseases, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    PLoS ONE 7:e34704. 2012
    ....
  67. doi request reprint Prevalence of metabolic syndrome and its relationship with clinically prevalent cardiovascular disease in the Veneto region, northeastern Italy
    Bruno Franco Novelletto
    SocietĂ  Italiana di Medicina Generale Padova, Padova, Italy
    Metab Syndr Relat Disord 10:56-62. 2012
    ..We wished to assess the prevalence of the metabolic syndrome and the role of its specific components on prevalent CVD in a large cohort of subjects from the general population...
  68. ncbi request reprint Maternal insulin therapy increases fetal endothelial progenitor cells during diabetic pregnancy
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Diabetes Care 31:808-10. 2008
  69. doi request reprint Continuous glucose monitoring reveals delayed nocturnal hypoglycemia after intermittent high-intensity exercise in nontrained patients with type 1 diabetes
    Alberto Maran
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Diabetes Technol Ther 12:763-8. 2010
    ..We assessed, by continuous glucose monitoring (CGM), the glucose profiles during and in the following 20h after a session of two different types of exercise...
  70. doi request reprint Technical notes on endothelial progenitor cells: ways to escape from the knowledge plateau
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Italy
    Atherosclerosis 197:496-503. 2008
    ..We uncover the many traps hidden in the choice of the right protocol, and suggest the best solutions on the basis of evidence and background theories...
  71. ncbi request reprint Insulin generates free radicals by an NAD(P)H, phosphatidylinositol 3'-kinase-dependent mechanism in human skin fibroblasts ex vivo
    Giulio Ceolotto
    Department of Clinical and Experimental Medicine, University of Padua Medical School, Via Giustiniani 2, 35128 Padua, Italy
    Diabetes 53:1344-51. 2004
    ..This effect of insulin may contribute to the pathogenesis and progression of cardiovascular disease in the insulin resistance syndrome...
  72. ncbi request reprint Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells: relationship to oxidative stress
    Elisa Pagnin
    Department of Clinical and Experimental Medicine, University of Padova School of Medicine, 35128 Padova, Italy
    J Clin Endocrinol Metab 90:1130-6. 2005
    ..p66(shc) gene expression in PBM may represent a useful tool to investigate the oxidative stress involved in the pathogenesis of long-term diabetic complications...
  73. ncbi request reprint The effects of oral amino acid intake on ambulatory capacity in elderly subjects
    Roldano Scognamiglio
    Division of Metabolic Diseases, University of Padova, Padova, Italy
    Aging Clin Exp Res 16:443-7. 2004
    ..This study was designed to assess the effects of dietary amino acid supplementation on effort tolerance in healthy elderly subjects with reduced physical activity...
  74. ncbi request reprint Detection of coronary artery disease in asymptomatic patients with type 2 diabetes mellitus
    Roldano Scognamiglio
    Metabolic Cardiology, Division of Metabolic Diseases, University of Padua Medical School, Padua, Italy
    J Am Coll Cardiol 47:65-71. 2006
    ..The criterion of > or = 2 RFs did not help to identify patients with a higher prevalence of CAD and is only related to a more severe coronary atherosclerosis with unfavorable anatomy...
  75. doi request reprint Cell-based methods for ex vivo evaluation of human endothelial biology
    Gian Paolo Fadini
    Metabolic Division, Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Cardiovasc Res 87:12-21. 2010
    ..In this review, we will summarize the current knowledge and the methodological perspective of these cell-based methods...
  76. ncbi request reprint Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Padova, Italy
    J Am Coll Cardiol 45:1449-57. 2005
    ..We sought to establish whether a reduction in endothelial progenitor cells (EPCs) has a putative role in peripheral vascular disease (PVD) of type 2 diabetic patients...
  77. doi request reprint Endothelial progenitor cells, bronchopulmonary dysplasia and other short-term outcomes of extremely preterm birth
    Giulia Paviotti
    Neonatal Intensive Care Unit, Respiratory Medicine, Department of Pediatrics, University of Padova, Italy
    Early Hum Dev 87:461-5. 2011
    ..To evaluate the impact of endothelial progenitor cells (EPCs), a subset of committed circulatory stem cells, on the development of bronchopulmonary dysplasia (BPD) and other short term outcomes in a cohort of extremely premature newborns...
  78. ncbi request reprint Endothelial progenitor cells and vascular biology in diabetes mellitus: current knowledge and future perspectives
    Gian P Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Via Giustiniani 2, 35128 Padova, Italy
    Curr Diabetes Rev 1:41-58. 2005
    ..In this review we focus on the relationships between EPCs and vascular biology, with particular regard to Diabetes Mellitus and future therapeutical implications...
  79. doi request reprint A stepwise approach to assess the impact of clustering cardiometabolic risk factors on carotid intima-media thickness: the metabolic syndrome no-more-than-additive
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Eur J Cardiovasc Prev Rehabil 15:190-6. 2008
    ..In this study, we explored the relationship between clustering cardiometabolic risk factors and carotid intima-media thickness (c-IMT)...
  80. doi request reprint At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Aging Cell 10:10-7. 2011
    ..The model described in this viewpoint article is therefore likely to be an oversimplification. Nevertheless, it represents one starting platform for understanding cell biology of lifespan in relation to the metabolic syndrome...
  81. ncbi request reprint Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II
    Andrea Semplicini
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    J Hypertens 24:1115-24. 2006
    ..RGS2-deficient mouse line exhibits a hypertensive phenotype and a prolonged response to vasoconstrictors...
  82. ncbi request reprint The emerging role of endothelial progenitor cells in pulmonary hypertension and diffuse lung diseases
    Gian Paolo Fadini
    University of Padua, Department of Clinical and Experimental Medicine, Italy
    Sarcoidosis Vasc Diffuse Lung Dis 24:85-93. 2007
    ..In this review, we will focus on the experimental and clinical data suggesting that EPC deregulation may have a role in the pathogenesis of vascular and parenchymal lung diseases...
  83. ncbi request reprint Elevated non-esterified fatty acids impair nitric oxide independent vasodilation, in humans: evidence for a role of inwardly rectifying potassium channels
    Saula Vigili de Kreutzenberg
    Department of Clinical and Experimental Medicine, Cattedra di Malattie del Metabolismo, University of Padova, Via Giustiniani 2, 35128 Padua, Italy
    Atherosclerosis 169:147-53. 2003
    ..Ouabain and BaCl(2)-mediated FBF inhibition was lower (P<0.01) at high-NEFA. During ouabain alone FBF decreased slightly...
  84. doi request reprint Reduced endothelial progenitor cells and brachial artery flow-mediated dilation as evidence of endothelial dysfunction in ocular hypertension and primary open-angle glaucoma
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Acta Ophthalmol 88:135-41. 2010
    ....
  85. ncbi request reprint Incidence of coronary heart disease in type 2 diabetic men and women: impact of microvascular complications, treatment, and geographic location
    Angelo Avogaro
    Division of Metabolic Diseases, University of Padua, Padua, Italy
    Diabetes Care 30:1241-7. 2007
    ..We set forth to determine incidence and identify predictors (including microvascular complications and treatment) of first coronary heart disease (CHD) event in CVD-free type 2 diabetic patients...
  86. ncbi request reprint Early myocardial dysfunction in the diabetic heart: current research and clinical applications
    Roldano Scognamiglio
    Metabolic Cardiology Unit, Giustinianco Hospital, Division of Metabolic Diseases, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Am J Cardiol 93:17A-20A. 2004
    ....
  87. ncbi request reprint Arterio-venous gradient of endothelial progenitor cells across renal artery stenosis
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Via Giustiniani 2, 35128 Padova, Italy
    Atherosclerosis 182:189-91. 2005
    ..Surprisingly, we found that EPCs were more abundant in venous than in arterial blood, suggesting that the kidney subjected to chronic ischemia may become a source rather than a target of EPCs...
  88. doi request reprint Why to screen heart disease in diabetes
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Metabolic Division and Diabetology, University of Padova Medical School, Padova, Italy
    Atherosclerosis 204:11-5. 2009
    ..In this article, we underline the importance of an early diagnosis of coronary artery disease and heart failure in diabetic patients, suggesting that positive screening tests have significant implications in clinical management...
  89. ncbi request reprint Metabolic and cardiovascular parameters in type 1 diabetes at extreme altitude
    Paola Pavan
    Division of Metabolic Diseases, University Hospital, University of Padova, Italy
    Med Sci Sports Exerc 36:1283-9. 2004
    ..Nevertheless, extreme altitude mountaineering represents a demanding challenge. We present the metabolic and cardiovascular parameters found in individuals with Type 1 diabetes during the ascent to Cho Oyu located at a height of 8201 m...
  90. doi request reprint Cardiovascular effects of DPP-4 inhibition: beyond GLP-1
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Faculty of Medicine, Padova, Italy
    Vascul Pharmacol 55:10-6. 2011
    ..The modulation of endothelial progenitor cells, inflammatory pathway and ischemic response emerges as the major cardiovascular target of DPP-4 inhibitors...
  91. doi request reprint The metabolic syndrome influences the response to incretin-based therapies
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Chair and Division of Metabolic Diseases, University of Padova, Medical School, Italy
    Acta Diabetol 48:219-25. 2011
    ..In conclusion, the presence of MS appears to modify the response to incretin-based therapies. Given the non-randomized nature of this study, these data need to be replicated...
  92. ncbi request reprint Acute effect of insulin on nitric oxide synthesis in humans: a precursor-product isotopic study
    Paolo Tessari
    Department of Clinical and Experimental Medicine, Metabolism Division, Policlinico Universitario, Via Giustiniani 2, 35128 Padua, Italy
    Am J Physiol Endocrinol Metab 293:E776-82. 2007
    ..13 +/- 0.35% (P < 0.003). In conclusion, whole body NO(x) synthesis can be directly measured over a short observation time with stable isotope methods in humans. Insulin acutely stimulates NO(x) synthesis from arginine...
  93. ncbi request reprint Effects of treatment with sulfonylurea drugs or insulin on ischemia-induced myocardial dysfunction in type 2 diabetes
    Roldano Scognamiglio
    Division of Cardiology, Department of Clinical and Experimental Medicine, University of Padua Medical School, Padua, Italy
    Diabetes 51:808-12. 2002
    ..Restitution of a preconditioning mechanism in insulin-treated patients may be the potential beneficial mechanism...
  94. doi request reprint Characteristics and mortality of type 2 diabetic patients hospitalized for severe iatrogenic hypoglycemia
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Padova, Italy
    Diabetes Res Clin Pract 84:267-72. 2009
    ..We aimed to describe clinical characteristics of type 2 diabetic patients hospitalized for iatrogenic hypoglycemia, and find predictors of long-term mortality, with a special regard to anti-hyperglycemic regimens...
  95. ncbi request reprint Corneal diabetic neuropathy: a confocal microscopy study
    Edoardo Midena
    Department of Ophthalmology, University of Padova, Italy
    J Refract Surg 22:S1047-52. 2006
    ..To evaluate the role of corneal confocal microscopy in the diagnosis of morphologic damage of the corneal sub-basal nerve plexus in diabetic patients and to correlate corneal confocal microscopy findings with peripheral diabetic neuropathy...
  96. ncbi request reprint The fatty acid composition of plasma phospholipids and the insulin sensitivity in elderly diabetic patients. The Pro.V.A. study
    Enzo Manzato
    Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
    Aging Clin Exp Res 14:474-8. 2002
    ..The prevalence of diabetes is increasing worldwide indicating that life-style habits are important determinants for this disease. The aim of this study was to examine the effects of dietary fats on insulin sensitivity in diabetic patients...
  97. ncbi request reprint Effects of oral amino acid supplementation on myocardial function in patients with type 2 diabetes mellitus
    Roldano Scognamiglio
    Division of Cardiology, Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Am Heart J 147:1106-12. 2004
    ..Diabetes mellitus is associated with an increased rate of cardiac amino acid catabolism that could interfere with cardiac function...
  98. doi request reprint Diabetic gait and posture abnormalities: a biomechanical investigation through three dimensional gait analysis
    Zimi Sawacha
    Department of Information Engineering, University of Padova, Padova, Italy
    Clin Biomech (Bristol, Avon) 24:722-8. 2009
    ..It is involved in the pathogenesis of the diabetic foot, which is a major cause of morbidity and mortality. The study aims to investigate the effects of diabetic polyneuropathy on gait and posture...