A Aversa

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. ncbi request reprint Testosterone:estradiol ratio changes associated with long-term tadalafil administration: a pilot study
    Emanuela A Greco
    Internal Medicine, Department of Medical Pathophysiology, University of Roma La Sapienza, Rome, Italy
    J Sex Med 3:716-22. 2006
  2. pmc Penile involvement in Systemic Sclerosis: New Diagnostic and Therapeutic Aspects
    Antonio Aversa
    Department of Experimental Medicine, Internal Medicine Unit, Universita degli Studi di Roma La Sapienza, 00161 Rome, Italy
    Int J Rheumatol 2010:708067. 2010
  3. pmc Cardiometabolic complications after androgen deprivation therapy in a man with prostate cancer: effects of 3 years intermittent testosterone supplementation
    Antonio Aversa
    Department of Experimental Medicine, Medical Physiopathology, Food Science and Endocrinology Section, Sapienza University of Rome Rome, Italy
    Front Endocrinol (Lausanne) 3:17. 2012
  4. pmc Peripheral arterial tonometry to measure the effects of vardenafil on sympathetic tone in men with lifelong premature ejaculation
    Davide Francomano
    Department of Experimental Medicine, Section of Medical Pathophysiology, Viale Regina Elena 324, Sapienza University of Rome, 00161 Rome, Italy
    Int J Endocrinol 2013:394934. 2013
  5. doi request reprint Weight loss by multidisciplinary intervention improves endothelial and sexual function in obese fertile women
    Antonio Aversa
    Department of Experimental Medicine, Medical Physiopathology, Food Science and Endocrinology Section, Viale Policlinico 155, Rome, Italy
    J Sex Med 10:1024-33. 2013
  6. doi request reprint A spontaneous, double-blind, double-dummy cross-over study on the effects of daily vardenafil on arterial stiffness in patients with vasculogenic erectile dysfunction
    Antonio Aversa
    Department of Experimental Medicine Medical Pathophysiology, Food Science and Endocrinology Section, University Sapienza, Rome, Italy
    Int J Cardiol 160:187-91. 2012
  7. doi request reprint A pilot study to evaluate the effects of vardenafil on sexual distress in men with obesity
    A Aversa
    Department Experimental Medicine, Medical Physiopathology, Food Science and Endocrinology Section, Sapienza University of Rome, Rome, Italy
    Int J Impot Res 24:122-5. 2012
  8. doi request reprint Effects of long-acting testosterone undecanoate on bone mineral density in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 36 months controlled study
    Antonio Aversa
    Department of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, Sapienza University of Rome, Rome, Italy
    Aging Male 15:96-102. 2012
  9. ncbi request reprint Relationship between chronic tadalafil administration and improvement of endothelial function in men with erectile dysfunction: a pilot study
    A Aversa
    Medical Pathophysiology, University of Rome La Sapienza, Rome, Italy
    Int J Impot Res 19:200-7. 2007
  10. doi request reprint Exposure to phosphodiesterase type 5 inhibitors stimulates aromatase expression in human adipocytes in vitro
    Antonio Aversa
    Department of Experimental Medicine, Section of Medical Pathophysiology Sapienza University of Rome, Rome, Italy
    J Sex Med 8:696-704. 2011

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Testosterone:estradiol ratio changes associated with long-term tadalafil administration: a pilot study
    Emanuela A Greco
    Internal Medicine, Department of Medical Pathophysiology, University of Roma La Sapienza, Rome, Italy
    J Sex Med 3:716-22. 2006
    ..It has been reported that lack of sexual activity due to erectile dysfunction (ED) may be associated with testosterone (T) decline...
  2. pmc Penile involvement in Systemic Sclerosis: New Diagnostic and Therapeutic Aspects
    Antonio Aversa
    Department of Experimental Medicine, Internal Medicine Unit, Universita degli Studi di Roma La Sapienza, 00161 Rome, Italy
    Int J Rheumatol 2010:708067. 2010
    ..Also, the beneficial effect of long-term PDE5i add-on therapy to SSc therapy in the treatment of Raynaud's phenomenon is described...
  3. pmc Cardiometabolic complications after androgen deprivation therapy in a man with prostate cancer: effects of 3 years intermittent testosterone supplementation
    Antonio Aversa
    Department of Experimental Medicine, Medical Physiopathology, Food Science and Endocrinology Section, Sapienza University of Rome Rome, Italy
    Front Endocrinol (Lausanne) 3:17. 2012
    ....
  4. pmc Peripheral arterial tonometry to measure the effects of vardenafil on sympathetic tone in men with lifelong premature ejaculation
    Davide Francomano
    Department of Experimental Medicine, Section of Medical Pathophysiology, Viale Regina Elena 324, Sapienza University of Rome, 00161 Rome, Italy
    Int J Endocrinol 2013:394934. 2013
    ..01). Vardenafil was an effective treatment in men with LL-PE; improvements of IELT may be due to increased NO production which is able to reduce adrenergic overactivity and anxiety levels...
  5. doi request reprint Weight loss by multidisciplinary intervention improves endothelial and sexual function in obese fertile women
    Antonio Aversa
    Department of Experimental Medicine, Medical Physiopathology, Food Science and Endocrinology Section, Viale Policlinico 155, Rome, Italy
    J Sex Med 10:1024-33. 2013
    ..Weight loss in sexually active women improves their quality of life. At present, no studies have investigated whether weight loss may affect female sexual function in severe obese women...
  6. doi request reprint A spontaneous, double-blind, double-dummy cross-over study on the effects of daily vardenafil on arterial stiffness in patients with vasculogenic erectile dysfunction
    Antonio Aversa
    Department of Experimental Medicine Medical Pathophysiology, Food Science and Endocrinology Section, University Sapienza, Rome, Italy
    Int J Cardiol 160:187-91. 2012
    ..The effects of daily vardenafil on endothelial function and arterial stiffness in patients with erectile dysfunction (ED) have never been investigated...
  7. doi request reprint A pilot study to evaluate the effects of vardenafil on sexual distress in men with obesity
    A Aversa
    Department Experimental Medicine, Medical Physiopathology, Food Science and Endocrinology Section, Sapienza University of Rome, Rome, Italy
    Int J Impot Res 24:122-5. 2012
    ..Our preliminary results suggest that treatment with VAR may improve ejaculatory control, thus ameliorating self-esteem and sexual performance in men with obesity...
  8. doi request reprint Effects of long-acting testosterone undecanoate on bone mineral density in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 36 months controlled study
    Antonio Aversa
    Department of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, Sapienza University of Rome, Rome, Italy
    Aging Male 15:96-102. 2012
    ..Long-term TRT in middle-aged men with LOH and MS determines a significant increase in both vertebral and femoral BMD related to increased serum T levels, probably independently from estradiol modifications...
  9. ncbi request reprint Relationship between chronic tadalafil administration and improvement of endothelial function in men with erectile dysfunction: a pilot study
    A Aversa
    Medical Pathophysiology, University of Rome La Sapienza, Rome, Italy
    Int J Impot Res 19:200-7. 2007
    ..Chronic treatment also produces a dramatic increase in morning erections, which determines better oxygenation to the penis, thus providing a rationale for vascular rehabilitation...
  10. doi request reprint Exposure to phosphodiesterase type 5 inhibitors stimulates aromatase expression in human adipocytes in vitro
    Antonio Aversa
    Department of Experimental Medicine, Section of Medical Pathophysiology Sapienza University of Rome, Rome, Italy
    J Sex Med 8:696-704. 2011
    ..Prolonged tadalafil administration in men with erectile dysfunction is associated with increased testosterone (T): estradiol (E(2)) ratio mainly related to reduction of E(2) levels...
  11. doi request reprint Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation
    A Aversa
    Chair of Internal Medicine, DFM, Sapienza University of Rome, Italy
    Int J Impot Res 21:221-7. 2009
    ..In conclusion, in our study, vardenafil increased IELT and reduced PERT in men with LL-PE. Besides, improvements in confidence, perception of ejaculatory control and overall sexual satisfaction were reported...
  12. ncbi request reprint Phosphodiesterase 5 inhibitors in the treatment of erectile dysfunction
    Antonio Aversa
    Department of Medical Pathophysiology, University La Sapienza 00161 Rome Italy
    Curr Pharm Des 12:3467-84. 2006
    ....
  13. ncbi request reprint The penile vasculature in systemic sclerosis: A duplex ultrasound study
    Antonio Aversa
    Department of Medical Pathophysiology, University of Rome Lae Sapienza, Rome, Italy
    J Sex Med 3:554-8. 2006
    ..The role of ultrasound in the investigation of penile pathology is well established as vasculogenic impotence accounts for more than 30% out of overall causes...
  14. doi request reprint Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 24-month, randomized, double-blind, placebo-controlled study
    Antonio Aversa
    Department of Medical Pathophysiology, Sapienza University of Rome, Italy
    J Sex Med 7:3495-503. 2010
    ..Longitudinal studies have demonstrated that male hypogonadism could be considered a surrogate marker of incident cardiovascular disease...
  15. doi request reprint Efficacy and safety of two different testosterone undecanoate formulations in hypogonadal men with metabolic syndrome
    A Aversa
    Department of Experimental Medicine, Sapienza University of Rome, Viale Policlinico 155, Rome, Italy
    J Endocrinol Invest 33:776-83. 2010
    ..To investigate efficacy and safety of two different preparations of testosterone undecanoate (TU) in 52 hypogonadal men [mean age 57 yr and mean testosterone (T) < 320 ng/dl] with metabolic syndrome (MS)...
  16. doi request reprint The application of digital pulse amplitude tonometry to the diagnostic investigation of endothelial dysfunction in men with erectile dysfunction
    A Aversa
    Department of Medical Pathophysiology, Sapienza Universita di Roma, Italy
    Andrologia 43:9-15. 2011
    ....
  17. ncbi request reprint Endothelial dysfunction and erectile dysfunction in the aging man
    Antonio Aversa
    Department of Medical Pathophysiology, Sapienza University of Rome, Rome, Italy
    Int J Urol 17:38-47. 2010
    ..The aim of this review is to discuss the pathophysiology of endothelial dysfunction and its relationship with ED in the aging male, and to suggest possible strategies to improve arterial function with regard to sexual dysfunctions...
  18. ncbi request reprint Endothelial effects of drugs designed to treat erectile dysfunction
    Antonio Aversa
    Internal Medicine Unit, Medical Pathophysiology Department, Sapienza University of Rome, Viale del Policlinico 155, Rome, Italy
    Curr Pharm Des 14:3768-78. 2008
    ..on-demand PDE5-i in difficult patients is discussed...
  19. doi request reprint Chronic administration of Sildenafil improves markers of endothelial function in men with Type 2 diabetes
    A Aversa
    Department of Medical Pathophysiology, Sapienza University of Rome, Rome, Italy
    Diabet Med 25:37-44. 2008
    ..The aim of this study was to determine the effects of chronic therapy with sildenafil on endothelial function in patients with Type 2 diabetes mellitus (DM2)...
  20. ncbi request reprint Are subjects with erectile dysfunction aware of their condition? Results from a retrospective study based on an Italian free-call information service
    A Aversa
    Department of Medical Pathophysiology, University La Sapienza, Rome, Italy
    J Endocrinol Invest 27:548-56. 2004
    ..Effective prevention of ED commences with better awareness of the pathological causes by the population and modification of risk factors by the doctors...
  21. doi request reprint Is there a role for phosphodiesterase type-5 inhibitors in the treatment of premature ejaculation?
    A Aversa
    Department of Medical Pathophysiology, Sapienza University of Rome, Rome, Italy
    Int J Impot Res 23:17-23. 2011
    ..The aim of this review is to discuss basic rationale and to show clinical evidence sustaining the possibility to use off-label PDE5-i's to treat PE...
  22. ncbi request reprint Diagnosing erectile dysfunction: the penile dynamic colour duplex ultrasound revisited
    A Aversa
    Chair of Internal Medicine, Department of Medical Pathophysiology, University La Sapienza, Rome, Italy
    Int J Androl 28:61-3. 2005
    ..e. selective arteriography and dynamic infusion cavernosometry along with cavernosography...
  23. doi request reprint Early endothelial dysfunction as a marker of vasculogenic erectile dysfunction in young habitual cannabis users
    A Aversa
    Chair of Internal Medicine, Department of Medical Pathophysiology, Sapienza University of Rome, Rome, Italy
    Int J Impot Res 20:566-73. 2008
    ..Further studies are warranted to establish a direct relationship between cannabis abuse, onset of insulin resistance and development of vascular ED...
  24. ncbi request reprint Androgens and penile erection: evidence for a direct relationship between free testosterone and cavernous vasodilation in men with erectile dysfunction
    A Aversa
    Cattedra di Andrologia, Dipartimento di Fisiopatologia Medica, Universita La Sapienza, Cattedra di Endocrinologia, Universita Tor Vergata, Rome, Italy
    Clin Endocrinol (Oxf) 53:517-22. 2000
    ..The objective of the present study was to investigate the role of androgens in regulating trabecular smooth muscle relaxation in the corpus cavernosum in response to vasoactive challenge in men with erectile dysfunction (ED)...
  25. ncbi request reprint Is obesity protective for osteoporosis? Evaluation of bone mineral density in individuals with high body mass index
    E A Greco
    Dipartimento di Fisiopatologia Medica, Sapienza Universita di Roma, Policlinico Umberto I, 00161 Rome, Italy
    Int J Clin Pract 64:817-20. 2010
    ..The aim of this study was to characterise bone mineral density (BMD) in overweight (BMI > 25 < 29.9) and obese (BMI > 30) patients...
  26. ncbi request reprint Erectile dysfunction: expectations beyond phosphodiesterase type 5 inhibition
    A Aversa
    Department of Medical Phisiopathology, University La Sapienza, Rome, Italy
    J Endocrinol Invest 27:192-206. 2004
    ....
  27. ncbi request reprint Plasma adrenomedullin and endothelin-1 levels are reduced and Raynaud's phenomenon improved by daily tadalafil administration in male patients with systemic sclerosis
    E Rosato
    Department of Clinical Immunology and Allergy, Sapienza University of Rome, Rome, Italy
    J Biol Regul Homeost Agents 23:23-9. 2009
    ..The results of our study lead us to postulate the beneficial effect of adding long term inhibition of Phosphodiesterase type 5 to Systemic Sclerosis' therapy...
  28. ncbi request reprint The therapeutic dilemma: how to use short-acting PDE5 inhibitor drugs
    A Fabbri
    Chair of Endocrinology, Department of Internal Medicine, University Tor Vergata, Rome, Italy
    Int J Androl 28:69-73. 2005
    ..Aim of this article will be to review the different efficacy and safety profiles of oral short-acting compounds and to give indication for treatment of special populations of men with ED...
  29. ncbi request reprint Non-invasive vascular imaging for erectile dysfunction
    A Aversa
    AFaR CRCCS, Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy
    J Endocrinol Invest 26:122-4. 2003
    ..Other vascular testing--i.e. natural penile tumescence, cavernosometry/graphy, angiography are reserved to selected patients in whom CDDU alone has provided inconsistent information...
  30. ncbi request reprint Re-dosing of prostaglandin-E1 versus prostaglandin-E1 plus phentolamine in male erectile dysfunction: a dynamic color power Doppler study
    A Aversa
    Cattedra di Andrologia, Dipartimento Fisiopatologia Medica, Universita La Sapienza, Rome, Italy
    Int J Impot Res 12:33-40. 2000
    ..We conclude that re-dosing of PGE1/PHE mixture is a safe and effective procedure to maximize erectile response during dynamic CPD sonography and has a better diagnostic sensitivity than re-dosing of PGE1 alone...
  31. ncbi request reprint Low testosterone levels are associated with coronary artery disease in male patients with angina
    G M C Rosano
    Centre for Clinical and Basic Research, IRCCS San Raffaele, Rome, Italy
    Int J Impot Res 19:176-82. 2007
    ..These changes are inversely correlated to the degree of CAD, suggesting that low plasma testosterone may be involved with the increased risk of CAD in men...
  32. ncbi request reprint Effects of testosterone on sexual function in men: results of a meta-analysis
    Andrea M Isidori
    Cattedra di Andrologia, Universita La Sapienza, Rome, Italy
    Clin Endocrinol (Oxf) 63:381-94. 2005
    ..The aim of this study was to assess and compare the effects of T on the different domains of sexual life...
  33. ncbi request reprint Combining testosterone and PDE5 inhibitors in erectile dysfunction: basic rationale and clinical evidences
    Emanuela A Greco
    Department of Medical Pathophysiology, University of Rome La Sapienza, 00161 Rome, Italy
    Eur Urol 50:940-7. 2006
    ..Erectile dysfunction (ED) and decline of testosterone levels are frequently observed with age and also in illnesses with a common basis of endothelial damage...
  34. ncbi request reprint Pathology of erection
    A Fabbri
    Endocrinology Section, University of Rome Tor Vergata, Rome, Italy
    J Endocrinol Invest 26:87-90. 2003
    ..Finally, trauma or surgery affecting either the nervous system or interfering with the blood supply to the penis are associated with increased incidence of ED...
  35. ncbi request reprint Chronic treatment with tadalafil improves endothelial function in men with increased cardiovascular risk
    Giuseppe M C Rosano
    Cardiovascular Research Unit, Department of Medical Sciences, San Raffaele Roma, Tosinvest Sanita, Rome, Italy
    Eur Urol 47:214-20; discussion 220-2. 2005
    ..Aim of the study was to evaluate whether chronic therapy (4 weeks) with TAD improves endothelial function in patients with increased cardiovascular risk and whether this effect is sustained after discontinuation of therapy...
  36. ncbi request reprint Chronic sildenafil in men with diabetes and erectile dysfunction
    Antonio Aversa
    University of Rome La Sapienza, Dept of Medical Pathophysiology, Viale Policlinico 155 00161 Rome, Italy
    Expert Opin Drug Metab Toxicol 3:451-64. 2007
    ..If this approach proves successful, it will determine many advantages over the intracavernosal treatment and potentially induce sexual rehabilitation...
  37. ncbi request reprint Cardiovascular effect of testosterone replacement therapy in aging male
    Davide Francomano
    Department of Medical Pathophysiology, Sapienza University of Rome
    Acta Biomed 81:101-6. 2010
    ....
  38. ncbi request reprint Androgens improve cavernous vasodilation and response to sildenafil in patients with erectile dysfunction
    Antonio Aversa
    AFaR CRCCS, Ospedale Fatebenefratelli Isola Tiberina, Rome, Italy
    Clin Endocrinol (Oxf) 58:632-8. 2003
    ..This led us to further investigate the effect(s) of androgen administration on cavernous arteries in patients failing sildenafil treatment...
  39. ncbi request reprint Hormonal supplementation and erectile dysfunction
    Antonio Aversa
    Cattedra di Medicina Interna, Department of Medical Pathophysiology, University La Sapienza, Viale Policlinico 155, 0061 Rome, Italy
    Eur Urol 45:535-8. 2004
    ....
  40. ncbi request reprint The role of penile color-duplex ultrasound for the evaluation of erectile dysfunction
    Antonio Aversa
    Department of Medical Pathophysiology, University of Rome La Sapienza, Rome, Italy
    J Sex Med 4:1437-47. 2007
    ..Various parameters, such as peak systolic flow velocity, end diastolic velocity, resistance index, acceleration time, and degree of arterial dilatation, have been suggested for the diagnosis of vascular ED by D-PCDU...
  41. ncbi request reprint Erectile dysfunction in systemic sclerosis: effects of longterm inhibition of phosphodiesterase type-5 on erectile function and plasma endothelin-1 levels
    Michele Proietti
    Department of Clinical Immunology and Allergy, Department of Medical Pathophysiology, University of Rome La Sapienza, Rome, Italy
    J Rheumatol 34:1712-7. 2007
    ....
  42. doi request reprint The ENDOTRIAL study: a spontaneous, open-label, randomized, multicenter, crossover study on the efficacy of sildenafil, tadalafil, and vardenafil in the treatment of erectile dysfunction
    Emmanuele A Jannini
    School of Sexology, Department of Experimental Medicine, University of L Aquila, Coppito, L Aquila, Italy
    J Sex Med 6:2547-60. 2009
    ..Although there are pharmacological differences between these three compounds, few comparative studies have been conducted to date...
  43. ncbi request reprint Penile pharmacotesting in diagnosing male erectile dysfunction: evidence for lack of accuracy and specificity
    Antonio Aversa
    AFaR CRCCS, Ospedale Fatebenefratelli Isola Tiberina, Cattedra di Endocrinologia, Universita Tor Vergata, Rome, Italy
    Int J Androl 25:6-10. 2002
    ..We conclude that PPT alone is a misleading diagnostic test to exclude vascular ED and that dynamic CDDU should be offered to pts investigated for male ED...
  44. ncbi request reprint Redefining the role of long-acting phosphodiesterase inhibitor tadalafil in the treatment of diabetic erectile dysfunction
    Roberto Bruzziches
    Dept Medical Pathophysiology, Sapienza University of Rome, Italy
    Curr Diabetes Rev 4:24-30. 2008
    ..e in diabetic population, and finally provide evidences for redefining the role of chronic treatment in selected group of patients...
  45. ncbi request reprint Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa
    Annamaria Morelli
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence 50139, Italy
    Endocrinology 145:2253-63. 2004
    ..In conclusion, we demonstrated, for the first time, that androgens positively regulate PDE5, thus providing a possible explanation about the highest abundance of this enzyme in male genital tract...
  46. ncbi request reprint Effects of testosterone on erectile function: implications for the therapy of erectile dysfunction
    Farid Saad
    GBU Gynecology Andrology, Bayer Schering Pharma, Berlin, Germany
    BJU Int 99:988-92. 2007
    ..Thus, androgen treatment in hypogonadic patients, including those unresponsive to PDE-5 inhibitors, often results in an improvement of ED. Testosterone therapy is safe and convenient, while rapidly correcting low testosterone levels...
  47. ncbi request reprint Androgen deficiency and hormone-replacement therapy
    Andrea M Isidori
    Dipartmento Fisiopatologia Medica, Universita La Sapienza di Roma, Italy
    BJU Int 96:212-6. 2005