Research Topics
Species | A ArgiolasSummaryAffiliation: University of Cagliari Country: Italy Publications
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Publications
Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocinSalvatora Succu
Bernard B Brodie Department of Neuroscience, Centre of Excellence for the Neurobiology of Addictions, University of Cagliari, S P Sestu Monserrato, Km 0 700, 09042 Monserrato, CA, Italy
Neuropharmacology 52:1034-43. 2007..g., penile erection) with those controlling sexual motivation and sexual arousal...- The neuropharmacology of yawningA Argiolas
Bernard B Brodie Department of Neuroscience, University of Cagliari and Center for Neuropharmacology, National Research Council, Italy
Eur J Pharmacol 343:1-16. 1998..In conclusion, in spite of some recent progress, little is known of, and more has to be done to identify, the neurochemical mechanisms underlying yawning at the central level... - Central control of penile erection: role of the paraventricular nucleus of the hypothalamusAntonio Argiolas
Bernard B Brodie Department of Neuroscience, Centre of Excellence for the Neurobiology of Addictions, University of Cagliari, S P Sestu Monserrato Km 0 700, 09042 Monserrato, Cagliari, Italy
Prog Neurobiol 76:1-21. 2005.... - The role of oxytocin and the paraventricular nucleus in the sexual behaviour of male mammalsAntonio Argiolas
Bernard B Brodie Department of Neuroscience and Center of Excellence for The Neurobiology of Addictions, University of Cagliari, Cittadella Universitaria, S P Sestu Monserrato, Km 0 700, 09042 Monserrato, CA, Italy
Physiol Behav 83:309-17. 2004.... - The neurophysiology of the sexual cycleA Argiolas
Bernard B Brodie Department of Neuroscience, Cittadella Universitaria, University of Cagliari, Sestu Monserrato, Italy
J Endocrinol Invest 26:20-2. 2003..Although the majority of results, which have clarified the mechanisms involved, have been performed in males, it is believed that similar mechanisms are also operative in females... - ACTH- and alpha-MSH-induced grooming, stretching, yawning and penile erection in male rats: site of action in the brain and role of melanocortin receptorsA Argiolas
Bernard B Brodie Department of Neuroscience, Cagliari University, Cagliari, Italy
Brain Res Bull 51:425-31. 2000..The results show that ACTH(1-24) and alpha-MSH act in the hypothalamic periventricular region to induce the above responses and that grooming, stretching and yawning, but not penile erection, are mediated by melanocortin 4 receptors... - Neuropeptides and sexual behaviourA Argiolas
Bernard B Brodie Department of Neuroscience and Centre for Neuropharmacology, National Research Council, Cagliari, Italy
Neurosci Biobehav Rev 23:1127-42. 1999..Although still in the early stages, it is likely that these methodologies will provide new insights into the role of neuropeptides in the control of sexual behaviour... - The cannabinoid CB1 receptor antagonist SR 141716A induces penile erection by increasing extra-cellular glutamic acid in the paraventricular nucleus of male ratsSalvatora Succu
Bernard B. Brodie Department of Neuroscience and Centre of Excellence for the Neurobiology of Addictions, University of Cagliari, S.P. Sestu-Monserrato, Km 0.700, 09042 Monserrato, Italy
Behav Brain Res 169:274-81. 2006..The present results show that SR 141716A induces penile erection by activating glutamic acid neurotransmission, which causes in turn the activation of paraventricular oxytocinergic neurons mediating penile erection... - Activation of gamma-aminobutyric acid(A) receptors in the paraventricular nucleus of the hypothalamus reduces apomorphine-, N-methyl-D-aspartic acid- and oxytocin-induced penile erection and yawning in male ratsM Rosaria Melis
Bernard B Brodie Department of Neuroscience, University of Cagliari, Via Porcell 4, 09124, Cagliari, Italy
Neurosci Lett 281:127-30. 2000..The present results show that gamma-aminobutyric acid (GABA) inhibits penile erection and yawning by acting on GABA(A) receptors in the paraventricular nucleus of the hypothalamus... - Pro-VGF-derived peptides induce penile erection in male rats: Involvement of paraventricular nitric oxideSalvatora Succu
Bernard B. Brodie Department of Neuroscience and Center of Excellence for the Neurobiology of Addiction, University of Cagliari, S.P. Monserrato-Sestu, Km 0.700, 09042 Monserrato (CA, Italy
Neuropharmacology 49:1017-25. 2005.... - The activation of gamma aminobutyric acid(A) receptors in the paraventricular nucleus of the hypothalamus reduces non-contact penile erections in male ratsM R Melis
Bernard B Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria, SP Sestu Monserrato, 09042 Moserrato, CA, Italy
Neurosci Lett 314:123-6. 2001.... - Activation of GABAA and opioid receptors reduce penile erection induced by hexarelin peptidesSalvatora Succu
Bernard B. Brodie Department of Neuroscience and Center of Excellence for the Neurobiology of Addictions, University of Cagliari, Cittadella Universitaria, S.P. Monserrato-Sestu, Km 0.700, 09042 Monserrato (CA, Italy
Pharmacol Biochem Behav 76:563-70. 2003.... 
Oxytocin induces penile erection when injected into the ventral tegmental area of male rats: role of nitric oxide and cyclic GMPSalvatora Succu
Bernard B Brodie Department of Neuroscience, University of Cagliari, 09042 Monserrato, Italy
Eur J Neurosci 28:813-21. 2008..NO in turn activates guanylate cyclase present in these neurons, thereby increasing cyclic GMP concentration...- Effect of excitatory amino acid, dopamine, and oxytocin receptor antagonists on noncontact penile erections and paraventricular nitric oxide production in male ratsM R Melis
Bernard B Brodie Department of Neuroscience, University of Cagliari, Italy
Behav Neurosci 114:849-57. 2000..This may contribute to increased NO production in the PVN, and it may activate oxytocin neurons mediating this sexual response... - Pro-VGF-derived peptides induce penile erection in male rats: possible involvement of oxytocinSalvatora Succu
Bernard B Brodie Department of Neuroscience and Center of Excellence for the Neurobiology of Addiction, S P Monserrato Sestu, Km 0 700, 09042 Monserrato, University of Cagliari, Italy
Eur J Neurosci 20:3035-40. 2004.... - The oxytocin antagonist d(CH2)5Tyr(Me)2-Orn8-vasotocin reduces non-contact penile erections in male ratsM R Melis
Bernard B Brodie Department of Neuroscience, University of Cagliari, Italy
Neurosci Lett 265:171-4. 1999..The present results show that central oxytocin is involved in the expression of penile erection induced not only by drugs but also by sexual physiological stimuli... - Phosphodiesterase type 5 inhibitors facilitate noncontact erections in male rats: site of action in the brain and mechanism of actionFabrizio Sanna
Bernard B Brodie Department of Neuroscience, University of Cagliari, Monserrato, Cagliari 09042, Italy
J Sex Med 6:2680-9. 2009..Orally active phosphodiesterase type 5 inhibitors (PDE5i), used in the treatment of erectile dysfunction, facilitate the relaxation of cavernous smooth muscle tissues by reducing the degradation of cyclic guanosine monophosphate... - Yawning: role of hypothalamic paraventricular nitric oxideM R Melis
Bernard B Brodie Department of Neuroscience and Center for Neuropharmacology, National Research Council, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
Zhongguo Yao Li Xue Bao 20:778-88. 1999.... - Cannabinoid CB1 receptors in the paraventricular nucleus and central control of penile erection: immunocytochemistry, autoradiography and behavioral studiesM P Castelli
Bernard B Brodie Department of Neuroscience, University of Cagliari, S P Sestu Monserrato, Km 0 700, 09042 Monserrato CA, Italy
Neuroscience 147:197-206. 2007..This increase is related to an enhanced pro-erectile effect of SR 141716A, which is still present 3 days after the end of the chronic treatment... - EP 91073 prevents EP 80661-induced penile erection: new evidence for the existence of specific EP peptide receptors mediating penile erectionM R Melis
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
Neuropharmacology 41:254-62. 2001.... - Central oxytocinergic neurotransmission: a drug target for the therapy of psychogenic erectile dysfunctionM R Melis
Bernard B. Brodie Department of Neuroscience, University of Cagliari, S.P. Sestu-Monserrato Km 0.700, 09042 Monserrato, Cagliari, Italy
Curr Drug Targets 4:55-66. 2003..These findings show that paraventricular oxytocinergic neurons projecting to extra-hypothalamic brain areas and to the spinal cord are a likely target for the treatment of erectile dysfunction of central origin... - Morphine reduces penile erection induced by the cannabinoid receptor antagonist SR 141617A in male rats: role of paraventricular glutamic acid and nitric oxideSalvatora Succu
Bernard B. Brodie Department of Neuroscience and Centre of Excellence for the Neurobiology of Addictions, University of Cagliari, SP Monserrato-Sestu, Italy
Neurosci Lett 404:1-5. 2006.... - Ghrelin injected into the paraventricular nucleus of the hypothalamus of male rats induces feeding but not penile erectionMaria Rosario Melis
Bernard B Brodie Department of Neuroscience, University of Cagliari, S P Sestu Monserrato, 09042 Monserrato, Italy
Neurosci Lett 329:339-43. 2002..The present results provide further support to the hypothesis that the GH secretagogue receptors mediating feeding are different from those mediating penile erection and activated by pro-erectile EP peptides... - Extracellular excitatory amino acids increase in the paraventricular nucleus of male rats during sexual activity: main role of N-methyl-d-aspartic acid receptors in erectile functionMaria Rosaria Melis
Bernard B Brodie Department of Neuroscience and Center of Excellence for The Neurobiology of Addictions, University of Cagliari, Cittadella Universitaria, S P Monserrato Sestu, Km 0 700, 09042 Monserrato CA, Italy
Eur J Neurosci 19:2569-75. 2004.... - Oxytocin injected into the ventral tegmental area induces penile erection and increases extracellular dopamine in the nucleus accumbens and paraventricular nucleus of the hypothalamus of male ratsMaria Rosaria Melis
Bernard B Brodie Department of Neuroscience, University of Cagliari, S P Sestu Monserrato, Monserrato, Italy
Eur J Neurosci 26:1026-35. 2007.... - Extra-cellular dopamine increases in the paraventricular nucleus of male rats during sexual activityMaria Rosaria Melis
Bernard B Brodie Department of Neuroscience, University of Cagliari, S P Monserrato Sestu, Km 0 700, 09042 Monserrato CA, Italy
Eur J Neurosci 17:1266-72. 2003.... - The cannabinoid antagonist SR 141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel high palatable foodTiziana Melis
Bernard B Brodie Department of Neuroscience, University of Cagliari, 09042 Monserrato, Cagliari, Italy
Neurosci Lett 419:231-5. 2007.... - Oxytocin induces penile erection when injected into the ventral subiculum: role of nitric oxide and glutamic acidMaria Rosaria Melis
Bernard B Brodie Department of Neuroscience, University of Cagliari, Cagliari Section, Cittadella Universitaria, SS 554, km 4 500, 09042 Monserrato, Cagliari, Italy
Neuropharmacology 58:1153-60. 2010..g., prefrontal cortex) modulating the activity of mesolimbic dopaminergic neurons... - PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brainMaria Rosaria Melis
Bernard B Brodie Department of Neuroscience, Centre of Excellence for the Neurobiology of Addictions, University of Cagliari, Italy
Eur J Neurosci 24:2021-30. 2006.... - Oxytocin injected into the ventral subiculum or the posteromedial cortical nucleus of the amygdala induces penile erection and increases extracellular dopamine levels in the nucleus accumbens of male ratsMaria Rosaria Melis
Bernard B Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria, Monserrato, Cagliari, Italy
Eur J Neurosci 30:1349-57. 2009..g. penile erection and copulatory performance), but also its motivational/reward aspects, confirming a key role of oxytocin and dopamine in these processes... - PD-168077, a selective dopamine D4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male ratsMaria Rosaria Melis
Bernard B Brodie Department of Neuroscience, Center of Excellence for the Neurobiology of Addictions, University of Cagliari, S P Sestu Monserrato, Km 0 700, 09042 Monserrato, Italy
Neurosci Lett 379:59-62. 2005..The present results show that D4 dopamine receptors present in the paraventricular nucleus may influence penile erection by modulating the activity of paraventricular oxytocinergic neurons mediating erectile function... - Reduction of drug-induced yawning and penile erection and of noncontact erections in male rats by the activation of GABAA receptors in the paraventricular nucleus: involvement of nitric oxideMaria Rosaria Melis
Bernard B Brodie Department of Neuroscience, University of Cagliari, S P Monserrato Sestu, Km 0 700, 09042 Monserrato CA, Italy
Eur J Neurosci 15:852-60. 2002.... - The cannabinoid receptor antagonist SR-141716A induces penile erection in male rats: involvement of paraventricular glutamic acid and nitric oxideMaria Rosaria Melis
Bernard B Brodie Department of Neuroscience and Centre of Excellence for The Neurobiology of Addictions, University of Cagliari, 09042 Monserrato, Italy
Neuropharmacology 50:219-28. 2006.... - Antagonism of cannabinoid CB1 receptors in the paraventricular nucleus of male rats induces penile erectionMaria Rosaria Melis
Bernard B Brodie Department of Neuroscience and Center of Excellence for The Neurobiology of Addictions, University of Cagliari, S P Sestu Monserrato, Km 0 700, 09042 Monserrato, CA, Italy
Neurosci Lett 359:17-20. 2004..The present results show that cannabinoid CB1 receptors present in the paraventricular nucleus may influence erectile function and sexual activity by modulating paraventricular oxytocinergic neurons mediating erectile function... - Selective expression of TLQP-21 and other VGF peptides in gastric neuroendocrine cells and modulation by feedingCarla Brancia
NEF Laboratory, Department of Cytomorphology, University of Cagliari, 09042 Monserrato Cagliari, Italy
J Endocrinol 207:329-41. 2010..The selective modulation of TLQP peptides suggests their involvement in peripheral neuro-endocrine mechanisms related to feeding responses and/or ECL cell regulation... - Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fastingMichela Bagnasco
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Via Vanvitelli, 32 20129 Milan, Italy
Regul Pept 111:161-7. 2003.... - 2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonistCecile Enguehard-Gueiffier
Laboratoire de Chimie Therapeutique, Faculte de Pharmacie, 31 Avenue Monge, F 37200 Tours, France
J Med Chem 49:3938-47. 2006..0 (46%) and 4.5 nM (57%), respectively. Our D4 agonist 3c induced penile erection in vivo when administered to rats. This effect was inhibited by L-745,870 a D4 selective antagonist, confirming the mechanistic pathway...