Antonio Di Sabatino

Summary

Affiliation: University of Pavia
Location: Pavia, Italy
Summary:
Dr. Antonio Di Sabatino is Senior Lecturer in Gastroenterology at the School of Medicine, University of Pavia (Italy, and he performs clinical activity at the First Department of Medicine, S. Matteo Hospital in Pavia. His scientific research has focused on gastroenterology with special reference to the immune pathogenesis of celiac disease and inflammatory bowel diseases, and in particular on how inappropriate immune reactions cause disease in the human gut.

Publications:
1: Di Sabatino A, Rovedatti L, Vidali F, Macdonald TT, Corazza GR. Recent advances in understanding Crohns disease. Intern Emerg Med. 2011 May 8. [Epub
ahead of print] PubMed PMID: .


2: Di Sabatino A, Brunetti L, Biancheri P, Ciccocioppo R, Guerci M, Casella C,Vidali F, Macdonald TT, Benazzo M, Corazza GR. Mucosal changes induced by ischemia-reperfusion injury in a jejunal loop transplanted in oropharynx. Intern
Emerg Med. 2011 May 8. [Epub ahead of print] PubMed PMID: .


3: Di Sabatino A, Paccagnini D, Vidali F, Rosu V, Biancheri P, Cossu A, Zanetti
S, Corazza GR, Sechi LA. Detection of Mycobacterium avium subsp. paratuberculosis
(MAP)-specific IS900 DNA and antibodies against MAP peptides and lysate in the
blood of Crohns disease patients. Inflamm Bowel Dis. 2011 May;17(5):1254-5. doi:
10.1002/ibd.21461. Epub 2010 Sep 2. PubMed PMID: .


4: Rovedatti L, Di Sabatino A, Knowles CH, Sengupta N, Biancheri P, Corazza GR,
Macdonald TT. Fibroblast activation protein expression in Crohns disease
strictures. Inflamm Bowel Dis. 2011 May;17(5):1251-3. doi: 10.1002/ibd.21446.
Epub 2010 Aug 30. PubMed PMID: .


5: De Leo V, Musacchio MC, Piomboni P, Di Sabatino A, Morgante G. The
administration of metformin during pregnancy reduces polycystic ovary syndrome
related gestational complications. Eur J Obstet Gynecol Reprod Biol. 2011 Apr 27.
[Epub ahead of print] PubMed PMID: .


6: Di Sabatino A, Biancheri P, Rovedatti L, Macdonald TT, Corazza GR. New
pathogenic paradigms in inflammatory bowel disease. Inflamm Bowel Dis. 2011 Apr
27. doi: 10.1002/ibd.21735. [Epub ahead of print] PubMed PMID: .


7: Di Sabatino A, Battista N, Biancheri P, Rapino C, Rovedatti L, Astarita G,
Vanoli A, Dainese E, Guerci M, Piomelli D, Pender SL, Macdonald TT, Maccarrone M,
Corazza GR. The endogenous cannabinoid system in the gut of patients with
inflammatory bowel disease. Mucosal Immunol. 2011 Apr 6. [Epub ahead of print]
PubMed PMID: .


8: Di Sabatino A, Carsetti R, Corazza GR. Post-splenectomy and hyposplenic
states. Lancet. 2011 Apr 5. [Epub ahead of print] PubMed PMID: .


9: Di Sabatino A, Rovedatti L, Vetrano S, Vidali F, Biancheri P, Rescigno M,
Danese S, Macdonald TT, Corazza GR. Involvement of CD40-CD40 ligand in
uncomplicated and refractory celiac disease. Am J Gastroenterol. 2011
Mar;106(3):519-27. Epub 2010 Dec 7. PubMed PMID: .


10: Fina D, Franz? E, Rovedatti L, Corazza GR, Biancone L, Sileri PP, Sica G,
MacDonald TT, Pallone F, Di Sabatino A, Monteleone G. Interleukin-25 production
is differently regulated by TNF-α and TGF-β1 in the human gut. Mucosal Immunol.
2011 Mar;4(2):239-44. Epub 2010 Oct 13. PubMed PMID: .


11: Morgante G, Orvieto R, Di Sabatino A, Musacchio MC, De Leo V. The role of
inositol supplementation in patients with polycystic ovary syndrome, with insulin
resistance, undergoing the low-dose gonadotropin ovulation induction regimen.
Fertil Steril. 2011 Feb 5. [Epub ahead of print] PubMed PMID: .


12: Di Sabatino A, Calarota SA, Vidali F, Macdonald TT, Corazza GR. Role of IL-15
in immune-mediated and infectious diseases. Cytokine Growth Factor Rev. 2011
Feb;22(1):19-33. Epub 2010 Nov 11. PubMed PMID: .


13: Papadia C, Kelly P, Caini S, Corazza GR, Shawa T, Franz? A, Forbes A, Di
Sabatino A. Plasma citrulline as a quantitative biomarker of HIV-associated
villous atrophy in a tropical enteropathy population. Clin Nutr. 2010
Dec;29(6):795-800. Epub 2010 Jun 19. PubMed PMID: .


14: Di Sabatino A, Biancheri P, Piconese S, Rosado MM, Ardizzone S, Rovedatti L,
Ubezio C, Massari A, Sampietro GM, Foschi D, Porro GB, Colombo MP, Carsetti R,
MacDonald TT, Corazza GR. Peripheral regulatory T cells and serum transforming
growth factor-β: relationship with clinical response to infliximab in Crohns
disease. Inflamm Bowel Dis. 2010 Nov;16(11):1891-7. PubMed PMID: .


15: Docena G, Rovedatti L, Kruidenier L, Fanning A, Leakey NA, Knowles CH, Lee K,
Shanahan F, Nally K, McLean PG, Di Sabatino A, MacDonald TT. Down-regulation of
p38 mitogen-activated protein kinase activation and proinflammatory cytokine
production by mitogen-activated protein kinase inhibitors in inflammatory bowel
disease. Clin Exp Immunol. 2010 Oct;162(1):108-15. doi:
10.1111/j.1365-2249.2010.04203.x. Epub 2010 Aug 20. PubMed PMID: ; PubMed
Central PMCID: PMC2990936.


16: De Leo V, Di Sabatino A, Musacchio MC, Morgante G, Scolaro V, Cianci A,
Petraglia F. Effect of oral contraceptives on markers of hyperandrogenism and
SHBG in women with polycystic ovary syndrome. Contraception. 2010
Sep;82(3):276-80. Epub 2010 Jul 16. PubMed PMID: .


17: Morgante G, Scolaro V, Tosti C, Di Sabatino A, Piomboni P, De Leo V.
[Treatment with carnitine, acetyl carnitine, L-arginine and ginseng improves
sperm motility and sexual health in men with asthenopermia]. Minerva Urol Nefrol.
2010 Sep;62(3):213-8. Italian. PubMed PMID: .


18: Vidali F, Di Sabatino A, Broglia F, Cazzola P, Biancheri P, Viera FT, Vanoli
A, Alvisi C, Perego M, Corazza GR. Increased CD8+ intraepithelial lymphocyte
infiltration and reduced surface area to volume ratio in the duodenum of patients
with ulcerative colitis. Scand J Gastroenterol. 2010 Jun;45(6):684-9. PubMed
PMID: .


19: Bergamaschi G, Di Sabatino A, Albertini R, Ardizzone S, Biancheri P, Bonetti
E, Cassinotti A, Cazzola P, Markopoulos K, Massari A, Rosti V, Porro GB, Corazza
GR. Prevalence and pathogenesis of anemia in inflammatory bowel disease.
Influence of anti-tumor necrosis factor-alpha treatment. Haematologica. 2010
Feb;95(2):199-205. Epub 2009 Oct 8. PubMed PMID: ; PubMed Central PMCID:
PMC2817021.


20: Rovedatti L, Kudo T, Biancheri P, Sarra M, Knowles CH, Rampton DS, Corazza
GR, Monteleone G, Di Sabatino A, Macdonald TT. Differential regulation of
interleukin 17 and interferon gamma production in inflammatory bowel disease.
Gut. 2009 Dec;58(12):1629-36. Epub 2009 Sep 8. PubMed PMID: .


21: MacDonald TT, Di Sabatino A. The immunologic basis for gastrointestinal food
allergy. Curr Opin Gastroenterol. 2009 Nov;25(6):521-6. Review. PubMed PMID:
.


22: Di Sabatino A, Vidali F, Cazzola P, Marchese A, Biancheri P, Biagi F, Corazza
GR. Splenic hypofunction in Whipples disease. Am J Gastroenterol. 2009
Oct;104(10):2641-3. PubMed PMID: .


23: De Leo V, Musacchio MC, Palermo V, Di Sabatino A, Morgante G, Petraglia F.
Polycystic ovary syndrome and metabolic comorbidities: therapeutic options. Drugs
Today (Barc). 2009 Oct;45(10):763-75. Review. PubMed PMID: .


24: Di Sabatino A, Saarialho-Kere U, Buckley MG, Gordon JN, Biancheri P,
Rovedatti L, Corazza GR, Macdonald TT, Pender SL. Stromelysin-1 and macrophage
metalloelastase expression in the intestinal mucosa of Crohns disease patients
treated with infliximab. Eur J Gastroenterol Hepatol. 2009 Sep;21(9):1049-55.
PubMed PMID: .


25: Rescigno M, Di Sabatino A. Dendritic cells in intestinal homeostasis and
disease. J Clin Invest. 2009 Sep;119(9):2441-50. doi: 10.1172/JCI39134. Epub 2009
Sep 1. Review. PubMed PMID: ; PubMed Central PMCID: PMC2735931.


26: Gordon JN, Prothero JD, Thornton CA, Pickard KM, Di Sabatino A, Goggin PM,
Pender SL, Macdonald TT. CC-10004 but not thalidomide or lenalidomide inhibits
lamina propria mononuclear cell TNF-α and MMP-3 production in patients with
inflammatory bowel disease. J Crohns Colitis. 2009 Sep;3(3):175-82. Epub 2009 Apr
10. PubMed PMID: .


27: Di Sabatino A, Rovedatti L, Kaur R, Spencer JP, Brown JT, Morisset VD,
Biancheri P, Leakey NA, Wilde JI, Scott L, Corazza GR, Lee K, Sengupta N, Knowles
CH, Gunthorpe MJ, McLean PG, MacDonald TT, Kruidenier L. Targeting gut T cell
Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and
T-box transcription factor T-bet in inflammatory bowel disease. J Immunol. 2009
Sep 1;183(5):3454-62. Epub 2009 Jul 31. PubMed PMID: .


28: MacDonald TT, Vossenkamper A, Di Sabatino A. Antigen presenting cells and T
cell interactions in the gastrointestinal tract. Mol Nutr Food Res. 2009
Aug;53(8):947-51. Review. Erratum in: Mol Nutr Food Res. 2009 Oct;53(10):1352.
Voessenkamper, Anna [corrected to Vossenkamper, Anna]. PubMed PMID: .


29: Di Sabatino A, Jackson CL, Pickard KM, Buckley M, Rovedatti L, Leakey NA,
Picariello L, Cazzola P, Monteleone G, Tonelli F, Corazza GR, MacDonald TT,
Pender SL. Transforming growth factor beta signalling and matrix
metalloproteinases in the mucosa overlying Crohns disease strictures. Gut. 2009
Jun;58(6):777-89. Epub 2009 Feb 6. PubMed PMID: .


30: Di Sabatino A, Rovedatti L, Rosado MM, Carsetti R, Corazza GR, MacDonald TT.
Increased expression of mucosal addressin cell adhesion molecule 1 in the
duodenum of patients with active celiac disease is associated with depletion of
integrin alpha4beta7-positive T cells in blood. Hum Pathol. 2009
May;40(5):699-704. Epub 2009 Jan 20. PubMed PMID: .


31: Di Sabatino A, Corazza GR. Coeliac disease. Lancet. 2009 Apr
25;373(9673):1480-93. PubMed PMID: .


32: Bergamaschi G, Markopoulos K, Albertini R, Di Sabatino A, Biagi F,
Ciccocioppo R, Arbustini E, Corazza GR. Anemia of chronic disease and defective
erythropoietin production in patients with celiac disease. Haematologica. 2008
Dec;93(12):1785-91. Epub 2008 Sep 24. PubMed PMID: .


33: Di Sabatino A, Miceli E, Dhaliwal W, Biancheri P, Salerno R, Cantoro L,
Vanoli A, De Vincenzi M, Blanco Cdel V, MacDonald TT, Corazza GR. Distribution,
proliferation, and function of Paneth cells in uncomplicated and complicated
adult celiac disease. Am J Clin Pathol. 2008 Jul;130(1):34-42. PubMed PMID:
.


34: Di Sabatino A, Pickard KM, Rampton D, Kruidenier L, Rovedatti L, Leakey NA,
Corazza GR, Monteleone G, MacDonald TT. Blockade of transforming growth factor
beta upregulates T-box transcription factor T-bet, and increases T helper cell
type 1 cytokine and matrix metalloproteinase-3 production in the human gut
mucosa. Gut. 2008 May;57(5):605-12. Epub 2008 Jan 4. PubMed PMID: .


35: Di Sabatino A, Rosado MM, Cazzola P, Biancheri P, Tinozzi FP, Laera MR,
Cantoro L, Vanoli A, Carsetti R, Corazza GR. Splenic function and IgM-memory B
cells in Crohns disease patients treated with infliximab. Inflamm Bowel Dis.
2008 May;14(5):591-6. PubMed PMID: .


36: Gordon JN, Pickard KM, Di Sabatino A, Prothero JD, Pender SL, Goggin PM,
MacDonald TT. Matrix metalloproteinase-3 production by gut IgG plasma cells in
chronic inflammatory bowel disease. Inflamm Bowel Dis. 2008 Feb;14(2):195-203.
PubMed PMID: .


37: Di Sabatino A, Rosado MM, Miele L, Capolunghi F, Cazzola P, Biancheri P,
Carsetti R, Gasbarrini G, Corazza GR. Impairment of splenic IgM-memory but not
switched-memory B cells in a patient with celiac disease and splenic atrophy. J
Allergy Clin Immunol. 2007 Dec;120(6):1461-3. Epub 2007 Sep 24. PubMed PMID:
.


38: Di Sabatino A, Pickard KM, Gordon JN, Salvati V, Mazzarella G, Beattie RM,
Vossenkaemper A, Rovedatti L, Leakey NA, Croft NM, Troncone R, Corazza GR, Stagg
AJ, Monteleone G, MacDonald TT. Evidence for the role of interferon-alfa
production by dendritic cells in the Th1 response in celiac disease.
Gastroenterology. 2007 Oct;133(4):1175-87. Epub 2007 Aug 14. PubMed PMID:
.


39: Di Sabatino A, Pender SL, Jackson CL, Prothero JD, Gordon JN, Picariello L,
Rovedatti L, Docena G, Monteleone G, Rampton DS, Tonelli F, Corazza GR, MacDonald
TT. Functional modulation of Crohns disease myofibroblasts by anti-tumor
necrosis factor antibodies. Gastroenterology. 2007 Jul;133(1):137-49. Epub 2007
May 5. PubMed PMID: .


40: Colombo PL, Benedetti M, Tinozzi FP, Ticozzelli E, Maroni N, Di Sabatino A,
Tinozzi S. [Different approaches for medical or surgical management of Crohns
disease: the importance of the classification of Vienna]. Ann Ital Chir. 2006
Nov-Dec;77(6):485-96. Review. Italian. PubMed PMID: .


41: Pender SL, Li CK, Di Sabatino A, MacDonald TT, Buckley MG. Role of macrophage
metalloelastase in gut inflammation. Ann N Y Acad Sci. 2006 Aug;1072:386-8.
Erratum in: Ann N Y Acad Sci. 2008 Apr;1126:333. Sabatino, A D I [corrected to Di
Sabatino, A]. PubMed PMID: .


42: MacDonald TT, Di Sabatino A. The exposure of infants to Lactobacillus
rhamnosus GG in Finland. J Pediatr Gastroenterol Nutr. 2006 May;42(5):476-8.
PubMed PMID: .


43: Ciccocioppo R, Finamore A, Ara C, Di Sabatino A, Mengheri E, Corazza GR.
Altered expression, localization, and phosphorylation of epithelial junctional
proteins in celiac disease. Am J Clin Pathol. 2006 Apr;125(4):502-11. PubMed
PMID: .


44: Di Sabatino A, Ciccocioppo R, Cupelli F, Cinque B, Millimaggi D, Clarkson MM,
Paulli M, Cifone MG, Corazza GR. Epithelium derived interleukin 15 regulates
intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in
coeliac disease. Gut. 2006 Apr;55(4):469-77. Epub 2005 Aug 16. PubMed PMID:
; PubMed Central PMCID: PMC1856172.


45: Di Sabatino A, Rosado MM, Cazzola P, Riboni R, Biagi F, Carsetti R, Corazza
GR. Splenic hypofunction and the spectrum of autoimmune and malignant
complications in celiac disease. Clin Gastroenterol Hepatol. 2006
Feb;4(2):179-86. PubMed PMID: .


46: Di Sabatino A, Morera R, Ciccocioppo R, Cazzola P, Gotti S, Tinozzi FP,
Tinozzi S, Corazza GR. Oral butyrate for mildly to moderately active Crohns
disease. Aliment Pharmacol Ther. 2005 Nov 1;22(9):789-94. PubMed PMID: .


47: Maconi G, Di Sabatino A, Ardizzone S, Greco S, Colombo E, Russo A, Cassinotti
A, Casini V, Corazza GR, Bianchi Porro G. Prevalence and clinical significance of
sonographic detection of enlarged regional lymph nodes in Crohns disease. Scand
J Gastroenterol. 2005 Nov;40(11):1328-33. PubMed PMID: .


48: Di Sabatino A, Rosado MM, Ciccocioppo R, Cazzola P, Morera R, Corazza GR,
Carsetti R. Depletion of immunoglobulin M memory B cells is associated with
splenic hypofunction in inflammatory bowel disease. Am J Gastroenterol. 2005
Aug;100(8):1788-95. PubMed PMID: .


49: Gordon JN, Di Sabatino A, Macdonald TT. The pathophysiologic rationale for
biological therapies in inflammatory bowel disease. Curr Opin Gastroenterol. 2005
Jul;21(4):431-7. Review. PubMed PMID: .


50: MacDonald TT, Di Sabatino A, Gordon JN. Immunopathogenesis of Crohns
disease. JPEN J Parenter Enteral Nutr. 2005 Jul-Aug;29(4 Suppl):S118-24;
discussion S124-5, S184-8. Review. Erratum in: JPEN J Parenter Enteral Nutr. 2006
Jan-Feb;30(1):table of contents. DiSabatino, Antonio [corrected to Di Sabatino,
Antonio]. PubMed PMID: .


51: Ciccocioppo R, Di Sabatino A, Corazza GR. The immune recognition of gluten in
coeliac disease. Clin Exp Immunol. 2005 Jun;140(3):408-16. Review. PubMed PMID:
; PubMed Central PMCID: PMC1809391.


52: Ciccocioppo R, Di Sabatino A, Bauer M, Della Riccia DN, Bizzini F, Biagi F,
Cifone MG, Corazza GR, Schuppan D. Matrix metalloproteinase pattern in celiac
duodenal mucosa. Lab Invest. 2005 Mar;85(3):397-407. PubMed PMID: .


53: Di Sabatino A, Carsetti R, Rosado MM, Ciccocioppo R, Cazzola P, Morera R,
Tinozzi FP, Tinozzi S, Corazza GR. Immunoglobulin M memory B cell decrease in
inflammatory bowel disease. Eur Rev Med Pharmacol Sci. 2004 Sep-Oct;8(5):199-203.
PubMed PMID: .


54: Di Sabatino A, Ciccocioppo R, Armellini E, Morera R, Ricevuti L, Cazzola P,
Fulle I, Corazza GR. Serum bFGF and VEGF correlate respectively with bowel wall
thickness and intramural blood flow in Crohns disease. Inflamm Bowel Dis. 2004
Sep;10(5):573-7. PubMed PMID: .


55: Di Sabatino A, Ciccocioppo R, Benazzato L, Sturniolo GC, Corazza GR.
Infliximab downregulates basic fibroblast growth factor and vascular endothelial
growth factor in Crohns disease patients. Aliment Pharmacol Ther. 2004 May
1;19(9):1019-24. PubMed PMID: .


56: Di Sabatino A, Armellini E, Corazza GR. Doppler sonography in the diagnosis
of inflammatory bowel disease. Dig Dis. 2004;22(1):63-6. Review. PubMed PMID:
.


57: Di Sabatino A, Boggero A, Miccoli FP, Cicolani B. Diversity, distribution and
ecology of water mites (Acari: Hydrachnidia and Halacaridae) in high Alpine lakes
(Central Alps, Italy). Exp Appl Acarol. 2004;34(1-2):199-210. PubMed PMID:
.


58: Di Sabatino A, Ciccocioppo R, Cinque B, Millimaggi D, Morera R, Ricevuti L,
Cifone MG, Corazza GR. Defective mucosal T cell death is sustainably reverted by
infliximab in a caspase dependent pathway in Crohns disease. Gut. 2004
Jan;53(1):70-7. PubMed PMID: ; PubMed Central PMCID: PMC1773915.


59: Ciccocioppo R, Di Sabatino A, Ara C, Biagi F, Perilli M, Amicosante G, Cifone
MG, Corazza GR. Gliadin and tissue transglutaminase complexes in normal and
coeliac duodenal mucosa. Clin Exp Immunol. 2003 Dec;134(3):516-24. PubMed PMID:
; PubMed Central PMCID: PMC1808891.


60: Di Sabatino A, Ciccocioppo R, Luinetti O, Ricevuti L, Morera R, Cifone MG,
Solcia E, Corazza GR. Increased enterocyte apoptosis in inflamed areas of Crohns
disease. Dis Colon Rectum. 2003 Nov;46(11):1498-507. PubMed PMID: .


61: Martucci S, Biagi F, Di Sabatino A, Corazza GR. Coeliac disease. Dig Liver
Dis. 2002 Sep;34 Suppl 2:S150-3. Review. PubMed PMID: .


62: Ciccocioppo R, Di Sabatino A, Luinetti O, Rossi M, Cifone MG, Corazza GR.
Small bowel enterocyte apoptosis and proliferation are increased in the elderly.
Gerontology. 2002 Jul-Aug;48(4):204-8. PubMed PMID: .


63: Di Sabatino A, Fulle I, Ciccocioppo R, Ricevuti L, Tinozzi FP, Tinozzi S,
Campani R, Corazza GR. Doppler enhancement after intravenous levovist injection
in Crohns disease. Inflamm Bowel Dis. 2002 Jul;8(4):251-7. PubMed PMID:
.


64: Ciccocioppo R, DAlo S, Di Sabatino A, Parroni R, Rossi M, Doglioni C, Cifone
MG, Corazza GR. Mechanisms of villous atrophy in autoimmune enteropathy and
coeliac disease. Clin Exp Immunol. 2002 Apr;128(1):88-93. PubMed PMID: ;
PubMed Central PMCID: PMC1906355.


65: Di Sabatino A, Ciccocioppo R, DAl? S, Parroni R, Millimaggi D, Cifone MG,
Corazza GR. Intraepithelial and lamina propria lymphocytes show distinct patterns
of apoptosis whereas both populations are active in Fas based cytotoxicity in
coeliac disease. Gut. 2001 Sep;49(3):380-6. PubMed PMID: ; PubMed Central
PMCID: PMC1728419.


66: Di Sabatino A, DAl? S, Millimaggi D, Ciccocioppo R, Parroni R, Sciarra G,
Cifone MG, Corazza GR. Apoptosis and peripheral blood lymphocyte depletion in
coeliac disease. Immunology. 2001 Aug;103(4):435-40. PubMed PMID: ;
PubMed Central PMCID: PMC1783265.


67: Di Sabatino A, Corazza GR. Surviving too long in Crohns disease. Gut. 2001
Jul;49(1):6-8. PubMed PMID: ; PubMed Central PMCID: PMC1728362.


68: Ciccocioppo R, Di Sabatino A, Parroni R, Muzi P, DAl? S, Ventura T, Pistoia
MA, Cifone MG, Corazza GR. Increased enterocyte apoptosis and Fas-Fas ligand
system in celiac disease. Am J Clin Pathol. 2001 Apr;115(4):494-503. PubMed PMID:
.


69: Ciccocioppo R, Di Sabatino A, Parroni R, Dal? S, Pistoia MA, Doglioni C,
Cifone MG, Corazza GR. Cytolytic mechanisms of intraepithelial lymphocytes in
coeliac disease (CoD). Clin Exp Immunol. 2000 May;120(2):235-40. PubMed PMID:
; PubMed Central PMCID: PMC1905653.


70: Ciccocioppo R, Di Sabatino A, Gasbarrini G, Corazza GR. Apoptosis and
gastrointestinal tract. Ital J Gastroenterol Hepatol. 1999 Mar;31(2):162-72.
Review. PubMed PMID: .


71: Corazza GR, Zoli G, Di Sabatino A, Ciccocioppo R, Gasbarrini G. A
reassessment of splenic hypofunction in celiac disease. Am J Gastroenterol. 1999
Feb;94(2):391-7. PubMed PMID: .


72: Di Sabatino A, Bertrandi E, Casadei Maldini M, Pennese F, Proietti F, Corazza
GR. Phenotyping of peripheral blood lymphocytes in adult coeliac disease.
Immunology. 1998 Dec;95(4):572-6. PubMed PMID: 9893047; PubMed Central PMCID:
PMC1364354.

Publications

  1. doi Recent advances in understanding Crohn's disease
    Antonio Di Sabatino
    First Department of Medicine, Centro per lo Studio e la Cura delle Malattie Infiammatorie Croniche Intestinali, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Intern Emerg Med 8:101-13. 2013
  2. doi Plasma citrulline as a quantitative biomarker of HIV-associated villous atrophy in a tropical enteropathy population
    Cinzia Papadia
    Department of Gastroenterology, University College Hospital, London, United Kingdom
    Clin Nutr 29:795-800. 2010
  3. doi Increased CD8+ intraepithelial lymphocyte infiltration and reduced surface area to volume ratio in the duodenum of patients with ulcerative colitis
    Francesca Vidali
    First Department of Medicine, Centro per lo Studio e la Cura delle Malattie Infiammatorie Croniche Intestinali, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Scand J Gastroenterol 45:684-9. 2010
  4. doi Polycystic ovary syndrome and metabolic comorbidities: therapeutic options
    V De Leo
    Department of Pediatrics, Obstetrics and Reproductive Medicine, Institute of Obstetrics and Gynecology, University of Siena, Siena, Italy Italy
    Drugs Today (Barc) 45:763-75. 2009
  5. pmc Prevalence and pathogenesis of anemia in inflammatory bowel disease. Influence of anti-tumor necrosis factor-alpha treatment
    Gaetano Bergamaschi
    Clinica, Medica I, Policlinico San Matteo, Piazzale Golgi, 27100 Pavia, Italy
    Haematologica 95:199-205. 2010
  6. ncbi Splenic hypofunction in Whipple's disease
    Antonio Di Sabatino
    Am J Gastroenterol 104:2641-3. 2009
  7. doi Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease
    L Rovedatti
    Institute of Cell and Molecular Science, London School of Medicine and Dentistry, London E1 2AT, UK
    Gut 58:1629-36. 2009
  8. pmc Dendritic cells in intestinal homeostasis and disease
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    J Clin Invest 119:2441-50. 2009
  9. doi Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease
    Antonio Di Sabatino
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    J Immunol 183:3454-62. 2009
  10. doi Antigen presenting cells and T cell interactions in the gastrointestinal tract
    Thomas T MacDonald
    Centre for Infectious Diseases, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    Mol Nutr Food Res 53:947-51. 2009

Collaborators

Detail Information

Publications65

  1. doi Recent advances in understanding Crohn's disease
    Antonio Di Sabatino
    First Department of Medicine, Centro per lo Studio e la Cura delle Malattie Infiammatorie Croniche Intestinali, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Intern Emerg Med 8:101-13. 2013
    ..This review is focused on novel advances in basic and clinical aspects of Crohn's disease, although it also deals with new trends in diagnosis and treatment...
  2. doi Plasma citrulline as a quantitative biomarker of HIV-associated villous atrophy in a tropical enteropathy population
    Cinzia Papadia
    Department of Gastroenterology, University College Hospital, London, United Kingdom
    Clin Nutr 29:795-800. 2010
    ..Our primary aim was to correlate serum citrulline with the degree of reduction of the enterocyte mass in HIV-infected patients with TE...
  3. doi Increased CD8+ intraepithelial lymphocyte infiltration and reduced surface area to volume ratio in the duodenum of patients with ulcerative colitis
    Francesca Vidali
    First Department of Medicine, Centro per lo Studio e la Cura delle Malattie Infiammatorie Croniche Intestinali, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Scand J Gastroenterol 45:684-9. 2010
    ..Recent evidence suggests the involvement of the upper gastrointestinal tract in ulcerative colitis (UC). By conducting a prospective controlled study, we explored the immunological abnormalities in the duodenal mucosa of UC patients...
  4. doi Polycystic ovary syndrome and metabolic comorbidities: therapeutic options
    V De Leo
    Department of Pediatrics, Obstetrics and Reproductive Medicine, Institute of Obstetrics and Gynecology, University of Siena, Siena, Italy Italy
    Drugs Today (Barc) 45:763-75. 2009
    ..In this review the metabolic comorbidities of PCOS and their therapeutic options are discussed...
  5. pmc Prevalence and pathogenesis of anemia in inflammatory bowel disease. Influence of anti-tumor necrosis factor-alpha treatment
    Gaetano Bergamaschi
    Clinica, Medica I, Policlinico San Matteo, Piazzale Golgi, 27100 Pavia, Italy
    Haematologica 95:199-205. 2010
    ..We investigated the prevalence and pathogenesis of anemia in patients with inflammatory bowel disease...
  6. ncbi Splenic hypofunction in Whipple's disease
    Antonio Di Sabatino
    Am J Gastroenterol 104:2641-3. 2009
  7. doi Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease
    L Rovedatti
    Institute of Cell and Molecular Science, London School of Medicine and Dentistry, London E1 2AT, UK
    Gut 58:1629-36. 2009
    ..Interleukin 17 (IL17) is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear...
  8. pmc Dendritic cells in intestinal homeostasis and disease
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    J Clin Invest 119:2441-50. 2009
    ....
  9. doi Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease
    Antonio Di Sabatino
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    J Immunol 183:3454-62. 2009
    ....
  10. doi Antigen presenting cells and T cell interactions in the gastrointestinal tract
    Thomas T MacDonald
    Centre for Infectious Diseases, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    Mol Nutr Food Res 53:947-51. 2009
    ..We present evidence that type I INF made by plasmacytoid dendritic cells may be important in coeliac disease...
  11. doi Coeliac disease
    Antonio Di Sabatino
    First Department of Medicine, Centro per lo Studio e la Cura della Malattia Celiaca, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Lancet 373:1480-93. 2009
    ..In this Seminar we critically reassess the clinical and diagnostic aspects of this disease and new perspectives in its pathogenesis and treatment...
  12. doi Stromelysin-1 and macrophage metalloelastase expression in the intestinal mucosa of Crohn's disease patients treated with infliximab
    Antonio Di Sabatino
    Centre for Infectious Disease, Institute of Cellular and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    Eur J Gastroenterol Hepatol 21:1049-55. 2009
    ..We focused on MMP-3 (stromelysin-1) and MMP-12 (macrophage metalloelastase) as these two enzymes have been linked to connective tissue destruction in CD...
  13. doi Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures
    A Di Sabatino
    First Department of Medicine, Fondazione IRCCS Policlinico S Matteo, Centro per lo Studio e la Cura delle Malattie Infiammatorie Croniche Intestinali, University of Pavia, Pavia, Italy
    Gut 58:777-89. 2009
    ..TGFbeta signalling was investigated by analysis of Smad proteins and MMPs/TIMPs in the mucosa overlying strictures in patients with Crohn's disease (CD)...
  14. doi Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin alpha4beta7-positive T cells in blood
    Antonio Di Sabatino
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, London E12AT, UK
    Hum Pathol 40:699-704. 2009
    ..We conclude that mucosal addressin cell adhesion molecule 1 may represent an important determinant for the generation of mucosal damage in celiac disease...
  15. doi Effect of oral contraceptives on markers of hyperandrogenism and SHBG in women with polycystic ovary syndrome
    Vincenzo De Leo
    Department of Pediatrics, Obstetrics and Reproductive Medicine, Institute of Obstetrics and Gynecology, University of Siena, Siena, Italy
    Contraception 82:276-80. 2010
    ....
  16. pmc Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease
    G Docena
    Centre for Infectious Disease and Centre for Academic Surgery, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    Clin Exp Immunol 162:108-15. 2010
    ..Additionally, all the p38α selective inhibitory drugs significantly down-regulated the activation of the MAPK pathway and the secretion of proinflammatory cytokines...
  17. doi Fibroblast activation protein expression in Crohn's disease strictures
    Laura Rovedatti
    Inflamm Bowel Dis 17:1251-3. 2011
  18. doi Mucosal changes induced by ischemia-reperfusion injury in a jejunal loop transplanted in oropharynx
    Antonio Di Sabatino
    First Department of Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Piazzale Golgi 19, 27100, Pavia, Italy
    Intern Emerg Med 8:317-25. 2013
    ..We identified alterations in lymphocyte infiltration, mucosal architecture and epithelial cell turnover, which may give a window to mechanisms of small bowel ischemia-reperfusion in humans...
  19. doi New pathogenic paradigms in inflammatory bowel disease
    Antonio Di Sabatino
    First Department of Medicine, Centro per Studio e Cura delle Malattie Infiammatorie Croniche Intestinali, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Inflamm Bowel Dis 18:368-71. 2012
    ..These new paradigms, together with the no longer "static" but "dynamic" vision of intestinal inflammation, highlight new possible therapeutic targets in inflammatory bowel disease...
  20. doi The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications
    V De Leo
    University of Siena, Departement of Pediatrics, Obstetric and Reproduction, S Maria alle Scotte Hospital, Bracci Street, 53100 Siena, Italy
    Eur J Obstet Gynecol Reprod Biol 157:63-6. 2011
    ..To prospectively evaluate the safety of metformin administration during pregnancy in a group of PCOS patients by assessing its effect on the prevalence of gestational complications and neonatal outcome...
  21. doi Post-splenectomy and hyposplenic states
    Antonio Di Sabatino
    First Department of Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S Matteo, University of Pavia, Italy
    Lancet 378:86-97. 2011
    ..In this Review, we critically assess clinical and diagnostic aspects of splenic dysfunction and highlight new perspectives in the prevention of overwhelming post-splenectomy infections...
  22. doi The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease
    A Di Sabatino
    First Department of Medicine, Fondazione IRCCS Policlinico S Matteo, Centro per lo Studio e la Cura delle Malattie Infiammatorie Croniche Intestinali, University of Pavia, Pavia, Italy
    Mucosal Immunol 4:574-83. 2011
    ..Although these results are promising, further studies are needed to determine the role of cannabinoid pathways in gut inflammation...
  23. doi The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen
    Giuseppe Morgante
    Department of Pediatrics, Obstetrics and Reproductive Medicine, Institute of Obstetrics and Gynecology, University of Siena, Siena, Italy
    Fertil Steril 95:2642-4. 2011
    ..Inositol nutritional supplementation produced very good clinical results with a significant reduction in cancellation rate (0 vs. 40%) and the consequent improvement in clinical pregnancy rate (PR) (33.3% vs. 13.3%)...
  24. ncbi CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-α and MMP-3 production in patients with inflammatory bowel disease
    J N Gordon
    Division of Infection, Inflammation and Repair, University of Southampton, School of Medicine, Southampton, UK Department of Gastroenterology, Royal Hampshire County Hospital, Winchester, UK
    J Crohns Colitis 3:175-82. 2009
    ....
  25. doi Involvement of CD40-CD40 ligand in uncomplicated and refractory celiac disease
    Antonio Di Sabatino
    First Department of Medicine, Fondazione IRCCS Policlinico S Matteo, Centro per lo Studio e Cura della Malattia Celiaca, University of Pavia, Pavia, Italy
    Am J Gastroenterol 106:519-27. 2011
    ....
  26. doi Role of IL-15 in immune-mediated and infectious diseases
    Antonio Di Sabatino
    First Department of Medicine, S Matteo Hospital, University of Pavia, Piazzale Golgi 5, 27100 Pavia, Italy
    Cytokine Growth Factor Rev 22:19-33. 2011
    ..Here, we discuss the current understanding of IL-15 role in immune-mediated and infectious diseases as well as its therapeutic use...
  27. doi Interleukin-25 production is differently regulated by TNF-α and TGF-β1 in the human gut
    D Fina
    Department of Internal Medicine, University Tor Vergata of Rome, Rome, Italy
    Mucosal Immunol 4:239-44. 2011
    ..Knockdown of Smad7 was accompanied by an increase in IL-25 production. Data show that IL-25 production is differently regulated by TNF-α and TGF-β1 in the human gut...
  28. ncbi [Treatment with carnitine, acetyl carnitine, L-arginine and ginseng improves sperm motility and sexual health in men with asthenopermia]
    G Morgante
    Dipartimento di Pediatria, Ginecologia e Medicina Riproduttiva, Universita di Siena, Siena, Italia
    Minerva Urol Nefrol 62:213-8. 2010
    ..This study examined the effect of treatment with carnitine, acetyl carnitine, L-arginine and ginseng in men with idiopathic asthenospermia and altered sexual function...
  29. doi Peripheral regulatory T cells and serum transforming growth factor-β: relationship with clinical response to infliximab in Crohn's disease
    Antonio Di Sabatino
    First Department of Medicine, Centro per lo Studio e Cura delle Malattie Infiammatorie Croniche Intestinali, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Inflamm Bowel Dis 16:1891-7. 2010
    ..Tumor necrosis factor (TNF)-α, which is centrally involved in Crohn's disease (CD) pathogenesis, also impairs Treg function. Here we investigated the influence of anti-TNF therapy on Treg frequency and function in CD...
  30. doi Detection of Mycobacterium avium subsp. paratuberculosis (MAP)-specific IS900 DNA and antibodies against MAP peptides and lysate in the blood of Crohn's disease patients
    Antonio Di Sabatino
    Inflamm Bowel Dis 17:1254-5. 2011
  31. doi Anemia of chronic disease and defective erythropoietin production in patients with celiac disease
    Gaetano Bergamaschi
    Department of Internal Medicine, University of Pavia Medical School and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Haematologica 93:1785-91. 2008
    ..Although celiac disease is a chronic condition characterized by an intense inflammatory response of the intestinal mucosa, scant data are available about the prevalence of anemia of chronic disease in celiac disease...
  32. doi Splenic function and IgM-memory B cells in Crohn's disease patients treated with infliximab
    Antonio Di Sabatino
    First Department of Medicine, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Inflamm Bowel Dis 14:591-6. 2008
    ..On this basis, we aimed to investigate the influence of anti-TNF therapy on splenic function in CD patients...
  33. ncbi Diversity, distribution and ecology of water mites (Acari: Hydrachnidia and Halacaridae) in high Alpine lakes (Central Alps, Italy)
    A Di Sabatino
    Dipartimento di Scienze Ambientali, University of L Aquila, Via Vetoio 20, 1 67100 Coppito L Aquila, Italy
    Exp Appl Acarol 34:199-210. 2004
    ..We conclude with some considerations of the influence of abiotic and biotic factors on the altitudinal and latitudinal distribution pattern of water mites...
  34. ncbi Serum bFGF and VEGF correlate respectively with bowel wall thickness and intramural blood flow in Crohn's disease
    Antonio Di Sabatino
    Gastroenterology Unit, IRCCS Policlinico S Matteo, University of Pavia, 27100, Italy
    Inflamm Bowel Dis 10:573-7. 2004
    ..The higher levels of VEGF in those patients with increased intramural blood flow suggests that VEGF may be considered a marker of angiogenesis in this condition...
  35. ncbi Infliximab downregulates basic fibroblast growth factor and vascular endothelial growth factor in Crohn's disease patients
    A Di Sabatino
    Gastroenterology Unit, IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Aliment Pharmacol Ther 19:1019-24. 2004
    ..The use of infliximab in the treatment of Crohn's disease patients with symptomatic stenosis is controversial...
  36. pmc Defective mucosal T cell death is sustainably reverted by infliximab in a caspase dependent pathway in Crohn's disease
    A Di Sabatino
    Gastroenterology Unit, IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Gut 53:70-7. 2004
    ....
  37. ncbi Increased enterocyte apoptosis in inflamed areas of Crohn's disease
    Antonio Di Sabatino
    Gastroenterology Unit, IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Dis Colon Rectum 46:1498-507. 2003
    ....
  38. ncbi Coeliac disease
    S Martucci
    Gastroenterology Unit, IRCCS Policlinico San Matteo, University of Pavia, Italy
    Dig Liver Dis 34:S150-3. 2002
    ..Extra-intestinal signs, i.e., alopecia, unexplained neurological disorders, cryptic hypertransaminasaemia, increased red cell width, frequently constitute the only clinical manifestation at the diagnosis...
  39. ncbi Small bowel enterocyte apoptosis and proliferation are increased in the elderly
    R Ciccocioppo
    Department of Internal Medicine, University of L Aquila, Italy
    Gerontology 48:204-8. 2002
    ..It is known that in the elderly the small bowel does not reveal structural and functional deteriorations in normal conditions, whereas the absorptive function is impaired in stress conditions...
  40. pmc Mechanisms of villous atrophy in autoimmune enteropathy and coeliac disease
    R Ciccocioppo
    Gastroenterology Unit, IRCCS Policlinico S Matteo, University of Pavia, Italy
    Clin Exp Immunol 128:88-93. 2002
    ..These results point to enterocyte autoantibody-dependent cellular cytotoxicity as the prevalent mechanism of increased enterocyte apoptosis in autoimmune enteropathy but not in coeliac disease...
  41. pmc Apoptosis and peripheral blood lymphocyte depletion in coeliac disease
    A Di Sabatino
    Gastroenterology Unit, IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy
    Immunology 103:435-40. 2001
    ..This increased apoptosis could be responsible for both lymphopenia and immunogenic exposure of phospholipids with subsequent production of autoantibodies...
  42. pmc Intraepithelial and lamina propria lymphocytes show distinct patterns of apoptosis whereas both populations are active in Fas based cytotoxicity in coeliac disease
    A Di Sabatino
    Gastroenterology Unit, IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Gut 49:380-6. 2001
    ..Increased LPL apoptosis is likely to downregulate mucosal inflammation whereas decreased IEL apoptosis could be responsible for autoimmune and malignant complications of CD...
  43. pmc Surviving too long in Crohn's disease
    A Di Sabatino
    Gastroenterology Unit, IRCCS Policlinico S Matteo University of Pavia, Pavia, Italy
    Gut 49:6-8. 2001
  44. ncbi Apoptosis and gastrointestinal tract
    R Ciccocioppo
    Department of Medicine, University of L Aquila, Italy
    Ital J Gastroenterol Hepatol 31:162-72. 1999
    ..This review will deal with the mechanisms potentially involved in apoptosis and with the clinical relevance of this phenomenon in gastrointestinal diseases...
  45. ncbi A reassessment of splenic hypofunction in celiac disease
    G R Corazza
    Gastroenterology Unit, University of Pavia, Italy
    Am J Gastroenterol 94:391-7. 1999
    ....
  46. pmc Phenotyping of peripheral blood lymphocytes in adult coeliac disease
    A Di Sabatino
    Department of Internal Medicine, University of L Aquila, L Aquila, Italy
    Immunology 95:572-6. 1998
    ..The decrease of natural killer cells and cytotoxic cells may be in keeping with the increased prevalence of malignancy in this condition. Finally, the phenotypic changes found in untreated coeliacs indicate T-cell activation...
  47. ncbi Matrix metalloproteinase pattern in celiac duodenal mucosa
    Rachele Ciccocioppo
    Gastroenterology Unit, IRCCS Policlinico San Matteo, University of Pavia, Italy
    Lab Invest 85:397-407. 2005
    ..In conclusion, our results show the presence of a peculiar MMP pattern in active CD strongly dominated by MMP-12, correlating either with IFN-gamma or the degree of mucosal damage...
  48. ncbi Immunoglobulin M memory B cell decrease in inflammatory bowel disease
    A Di Sabatino
    IRCCS Policlinico S Matteo, University of Pavia Pavia Italy
    Eur Rev Med Pharmacol Sci 8:199-203. 2004
    ..Since infections are one of the most frequent comorbid conditions in inflammatory bowel disease, we aimed to verify whether IgM memory B cell pool was decreased in Crohn's disease and ulcerative colitis patients...
  49. doi Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa
    A Di Sabatino
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts, London School of Medicine and Dentistry, Whitechapel, London E1 2AT, UK
    Gut 57:605-12. 2008
    ....
  50. ncbi Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease
    John N Gordon
    Division of Infection, Inflammation and Repair, University of Southampton, School of Medicine, Southampton, UK
    Inflamm Bowel Dis 14:195-203. 2008
    ..In this study we isolated gut PCs from patients with IBD and normal controls and analyzed cytokine production, matrix metalloproteinase (MMP)-3 and tissue inhibitor of metalloproteinase (TIMP)-1 production, and PC longevity ex vivo...
  51. ncbi Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies
    Antonio Di Sabatino
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Gastroenterology 133:137-49. 2007
    ..We investigated the action of infliximab on apoptosis, the production of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMP)-1, and migration of Crohn's disease (CD) myofibroblasts...
  52. ncbi [Different approaches for medical or surgical management of Crohn's disease: the importance of the classification of Vienna]
    Paolo Luigi Colombo
    Dipartimento di Scienze Chirurgiche e dei Trapianti d Organo, Istituto di Chirurgia Generale Gastroenterologica e Mammaria, Universita degli Studi di Pavia, IRCCS Policlinico San Matteo Pavia
    Ann Ital Chir 77:485-96. 2006
    ..e. fistulas) have a specific indication for immunosuppressive or anti-tumour necrosis factor-alpha therapy...
  53. ncbi Role of macrophage metalloelastase in gut inflammation
    Sylvia L F Pender
    Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, South Academic Block, Southampton General Hospital, Southampton SO16 6YD, UK
    Ann N Y Acad Sci 1072:386-8. 2006
    ..We have shown that MMP-3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP-12 in these idiopathic diseases...
  54. ncbi The exposure of infants to Lactobacillus rhamnosus GG in Finland
    Thomas T MacDonald
    J Pediatr Gastroenterol Nutr 42:476-8. 2006
  55. ncbi Altered expression, localization, and phosphorylation of epithelial junctional proteins in celiac disease
    Rachele Ciccocioppo
    First Department of Medicine, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Am J Clin Pathol 125:502-11. 2006
    ....
  56. ncbi Splenic hypofunction and the spectrum of autoimmune and malignant complications in celiac disease
    Antonio Di Sabatino
    First Department of Medicine, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S Matteo, University of Pavia, Piazzale Golgi 5, 27100 Pavia, Italy
    Clin Gastroenterol Hepatol 4:179-86. 2006
    ....
  57. ncbi The pathophysiologic rationale for biological therapies in inflammatory bowel disease
    John N Gordon
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Curr Opin Gastroenterol 21:431-7. 2005
    ..This review summarises important new developments in understanding this immune response and the downstream mechanisms of intestinal injury, alongside their potential role in opening up new avenues of treatment...
  58. ncbi Immunopathogenesis of Crohn's disease
    Thomas T MacDonald
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton, United Kingdom
    JPEN J Parenter Enteral Nutr 29:S118-24; discussion S124-5, S184-8. 2005
    ....
  59. ncbi Depletion of immunoglobulin M memory B cells is associated with splenic hypofunction in inflammatory bowel disease
    Antonio Di Sabatino
    Gastroenterology Unit, IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Am J Gastroenterol 100:1788-95. 2005
    ....
  60. ncbi Oral butyrate for mildly to moderately active Crohn's disease
    A Di Sabatino
    First Department of Medicine, IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Aliment Pharmacol Ther 22:789-94. 2005
    ..Butyrate exerts anti-inflammatory effects in experimental colitis and on Crohn's disease lamina propria mononuclear cells in vitro...
  61. ncbi Prevalence and clinical significance of sonographic detection of enlarged regional lymph nodes in Crohn's disease
    Giovanni Maconi
    Department of Gastroenterology, L Sacco University Hospital, Via G B Grassi 74, IT 20157 Milan, Italy
    Scand J Gastroenterol 40:1328-33. 2005
    ....
  62. doi The function of tissue transglutaminase in celiac disease
    Antonio Di Sabatino
    First Department of Medicine, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Autoimmun Rev 11:746-53. 2012
    ..This review is focused on the function of tTG in celiac disease, although it also deals with novel advances in tTG-based therapies...
  63. doi Recent advances in understanding ulcerative colitis
    Antonio Di Sabatino
    First Department of Medicine, Centro per lo Studio e la Cura delle Malattie Infiammatorie Croniche Intestinali, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Piazzale Golgi 19, 27100, Pavia, Italy
    Intern Emerg Med 7:103-11. 2012
    ..This review emphasizes novel concepts in the basic aspects of ulcerative colitis, and, in addition to the current clinical and diagnostic knowledge, it also describes new treatment options for this condition...
  64. doi Optimal use and cost-effectiveness of biologic therapies in inflammatory bowel disease
    Antonio Di Sabatino
    First Department of Medicine, Centro per lo Studio e la Cura delle Malattie Infiammatorie Croniche Intestinali, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Intern Emerg Med 6:17-27. 2011
    ..e. the chimeric human/murine antibody infliximab and the fully human antibody adalimumab...
  65. ncbi Variants of CARD15 are associated with an aggressive clinical course of Crohn's disease--an IG-IBD study
    Vito Annese
    Gastroenterology Unit, CSS IRCCS Hospital, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Italy
    Am J Gastroenterol 100:84-92. 2005
    ..Three major variants of the CARD15 gene confer susceptibility to Crohn's disease (CD). Whether or not these variants correlate with specific clinical features of the disease is under evaluation...