Alessandro Antonelli

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. doi request reprint CXCR3, CXCL10 and type 1 diabetes
    Alessandro Antonelli
    Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I 56126 Pisa, Italy Electronic address
    Cytokine Growth Factor Rev 25:57-65. 2014
  2. doi request reprint Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases
    Alessandro Antonelli
    Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, 56126 Pisa, Italy Electronic address
    Autoimmun Rev 13:272-80. 2014
  3. pmc Cervical lymph node metastases from thyroid cancer: does thyroglobulin and calcitonin measurement in fine needle aspirates improve the diagnostic value of cytology?
    Enke Baldini
    Department of Experimental Medicine, University of Rome, Rome, Italy
    BMC Clin Pathol 13:7. 2013
  4. doi request reprint Incidence of thyroid disorders in systemic sclerosis: results from a longitudinal follow-up
    Alessandro Antonelli
    Department of Clinical and Experimental Medicine, University of Pisa, I 56126 Pisa, Italy
    J Clin Endocrinol Metab 98:E1198-202. 2013
  5. ncbi request reprint High circulating chemokines (C-X-C motif) ligand 9, and (C-X-C motif) ligand 11, in hepatitis C-associated cryoglobulinemia
    A Antonelli
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    Int J Immunopathol Pharmacol 26:49-57. 2013
  6. doi request reprint Interferon-α, -β and -γ induce CXCL11 secretion in human thyrocytes: modulation by peroxisome proliferator-activated receptor γ agonists
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma 67, 56100 Pisa, Italy
    Immunobiology 218:690-5. 2013
  7. doi request reprint Peroxisome proliferator-activated receptor γ agonists reduce cell proliferation and viability and increase apoptosis in systemic sclerosis fibroblasts
    A Antonelli
    Department of Internal Medicine, Metabolism Unit, University of Pisa School of Medicine, Via Roma 67, I 56100 Pisa, Italy
    Br J Dermatol 168:129-35. 2013
  8. ncbi request reprint Chemokine (CXC motif) ligand 9 serum levels in mixed cryoglobulinaemia are associated with circulating levels of IFN-gamma and TNF-alpha
    Alessandro Antonelli
    Department of Internal Medicine University of Pisa School of Medicine, Pisa, Italy
    Clin Exp Rheumatol 30:864-70. 2012
  9. doi request reprint β (CCL2) and α (CXCL10) chemokine modulations by cytokines and peroxisome proliferator-activated receptor-α agonists in Graves' ophthalmopathy
    Alessandro Antonelli
    Department of Internal Medicine, School of Medicine, University of Pisa, Via Roma 67, I 56100 Pisa, Italy
    J Endocrinol 213:183-91. 2012
  10. doi request reprint Circulating CXCL11 and CXCL10 are increased in hepatitis C-associated cryoglobulinemia in the presence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma, 67, 56100 Pisa, Italy
    Mod Rheumatol 22:659-67. 2012

Detail Information

Publications90

  1. doi request reprint CXCR3, CXCL10 and type 1 diabetes
    Alessandro Antonelli
    Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I 56126 Pisa, Italy Electronic address
    Cytokine Growth Factor Rev 25:57-65. 2014
    ..CXCL10/CXCR3 system plays a critical role in the autoimmune process and in β-cells destruction in T1D. Blocking CXCL10 in new onset diabetes seems a possible approach for T1D treatment. ..
  2. doi request reprint Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases
    Alessandro Antonelli
    Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, 56126 Pisa, Italy Electronic address
    Autoimmun Rev 13:272-80. 2014
    ..Further studies are needed to investigate interactions between chemokines and cytokines in the pathogenesis of autoimmune diseases and to evaluate whether CXCL10 is a novel therapeutic target in various autoimmune diseases. ..
  3. pmc Cervical lymph node metastases from thyroid cancer: does thyroglobulin and calcitonin measurement in fine needle aspirates improve the diagnostic value of cytology?
    Enke Baldini
    Department of Experimental Medicine, University of Rome, Rome, Italy
    BMC Clin Pathol 13:7. 2013
    ....
  4. doi request reprint Incidence of thyroid disorders in systemic sclerosis: results from a longitudinal follow-up
    Alessandro Antonelli
    Department of Clinical and Experimental Medicine, University of Pisa, I 56126 Pisa, Italy
    J Clin Endocrinol Metab 98:E1198-202. 2013
    ..No study has evaluated longitudinally the incidence of new cases of thyroid autoimmunity and dysfunction in patients with SSc...
  5. ncbi request reprint High circulating chemokines (C-X-C motif) ligand 9, and (C-X-C motif) ligand 11, in hepatitis C-associated cryoglobulinemia
    A Antonelli
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    Int J Immunopathol Pharmacol 26:49-57. 2013
    ..Future studies on a larger cohort of patients are needed to evaluate the relevance of serum CXCL9 and CXCL11 determination as clinico-prognostic marker of MC+HCV...
  6. doi request reprint Interferon-α, -β and -γ induce CXCL11 secretion in human thyrocytes: modulation by peroxisome proliferator-activated receptor γ agonists
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma 67, 56100 Pisa, Italy
    Immunobiology 218:690-5. 2013
    ..Furthermore, PPAR-γ activation partially inhibits this process...
  7. doi request reprint Peroxisome proliferator-activated receptor γ agonists reduce cell proliferation and viability and increase apoptosis in systemic sclerosis fibroblasts
    A Antonelli
    Department of Internal Medicine, Metabolism Unit, University of Pisa School of Medicine, Via Roma 67, I 56100 Pisa, Italy
    Br J Dermatol 168:129-35. 2013
    ..No study has evaluated the effect of the peroxisome proliferator-activated receptor γ (PPARγ) agonists on cell viability, proliferation and apoptosis in cultured systemic sclerosis (SSc) fibroblasts...
  8. ncbi request reprint Chemokine (CXC motif) ligand 9 serum levels in mixed cryoglobulinaemia are associated with circulating levels of IFN-gamma and TNF-alpha
    Alessandro Antonelli
    Department of Internal Medicine University of Pisa School of Medicine, Pisa, Italy
    Clin Exp Rheumatol 30:864-70. 2012
    ..We aimed to measure CXCL9, IFN-γ and TNF-α in a series of MC+HCV to correlate these parameters to different clinical phenotypes...
  9. doi request reprint β (CCL2) and α (CXCL10) chemokine modulations by cytokines and peroxisome proliferator-activated receptor-α agonists in Graves' ophthalmopathy
    Alessandro Antonelli
    Department of Internal Medicine, School of Medicine, University of Pisa, Via Roma 67, I 56100 Pisa, Italy
    J Endocrinol 213:183-91. 2012
    ..PPARα activators inhibit the secretion of the main prototype α (CXCL10) and β (CCL2) chemokines in GO fibroblasts or preadipocytes, suggesting that PPARα may be involved in the modulation of the immune response in GO...
  10. doi request reprint Circulating CXCL11 and CXCL10 are increased in hepatitis C-associated cryoglobulinemia in the presence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma, 67, 56100 Pisa, Italy
    Mod Rheumatol 22:659-67. 2012
    ..The aim of the present study, therefore, was to evaluate serum CXCL11 levels in these patients...
  11. doi request reprint Variable modulation by cytokines and thiazolidinediones of the prototype Th1 chemokine CXCL10 in anaplastic thyroid cancer
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, 56126 Pisa, Italy
    Cytokine 59:218-22. 2012
    ..However, the pattern of modulation by IFN-γ, TNF-α or thiazolidinediones is extremely variable, suggesting that the intracellular pathways involved in the chemokine modulation in ATC have different types of deregulation...
  12. ncbi request reprint High serum levels of CXC (CXCL10) and CC (CCL2) chemokines in untreated essential hypertension
    A Antonelli
    Department of Internal Medicine, Metabolism Unit, University of Pisa School of Medicine, Pisa, Italy
    Int J Immunopathol Pharmacol 25:387-95. 2012
    ..In conclusion, this study demonstrates increased circulating levels of the prototype chemokines CXCL10 and CCL2 in patients with hypertension...
  13. doi request reprint Systemic sclerosis fibroblasts show specific alterations of interferon-γ and tumor necrosis factor-α-induced modulation of interleukin 6 and chemokine ligand 2
    Alessandro Antonelli
    Department of Internal Medicine, Metabolism Unit, University of Pisa School of Medicine, Pisa, Italy
    J Rheumatol 39:979-85. 2012
    ....
  14. doi request reprint RET TKI: potential role in thyroid cancers
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma 67, 56100 Pisa, Italy
    Curr Oncol Rep 14:97-104. 2012
    ..The aim of the introduction of these targeted therapies is to extend life duration assuring a good quality of life; however, further studies are needed to reach these goals...
  15. doi request reprint CLM94, a novel cyclic amide with anti-VEGFR-2 and antiangiogenic properties, is active against primary anaplastic thyroid cancer in vitro and in vivo
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma, 67, 56100, Pisa, Italy
    J Clin Endocrinol Metab 97:E528-36. 2012
    ..We have studied the antitumor activity of a novel cyclic amide, CLM94, with anti-vascular endothelial growth factor (VEGF) receptor-2 and antiangiogenic activity in primary anaplastic thyroid cancer (ATC) cells in vitro and in vivo...
  16. ncbi request reprint New targeted therapies for anaplastic thyroid cancer
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
    Anticancer Agents Med Chem 12:87-93. 2012
    ..The possibility of testing the sensitivity of primary ATC cells from each subject to different drugs could increase the effectiveness of the treatment in the next future...
  17. doi request reprint High serum levels of CXCL11 in mixed cryoglobulinemia are associated with increased circulating levels of interferon-γ
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
    J Rheumatol 38:1947-52. 2011
    ..No study has evaluated circulating chemokine C-X-C motif ligand (CXCL)11 in patients with "mixed cryoglobulinemia and chronic hepatitis C infection" (MC+HCV). We measured CXCL11, and correlated this measurement to the clinical phenotype...
  18. ncbi request reprint 3,5-diiodo-L-thyronine increases resting metabolic rate and reduces body weight without undesirable side effects
    A Antonelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Biol Regul Homeost Agents 25:655-60. 2011
    ..05) (about 4 percent), while the serum levels of FT3, FT4 and TSH, were unchanged. No side effects were observed at the cardiac level in either subject. No significant change was observed in the same subjects taking placebo...
  19. doi request reprint Peroxisome proliferator-activated receptor-α agonists modulate CXCL9 and CXCL11 chemokines in Graves' ophthalmopathy fibroblasts and preadipocytes
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, I 56100 Pisa, Italy
    Mol Cell Endocrinol 349:255-61. 2012
    ..This study first shows that PPARα activators inhibit CXCL9 and CXCL11 chemokines in normal and GO fibroblasts and preadipocytes, suggesting that PPARα may be involved in the modulation of the immune response in GO...
  20. doi request reprint Parallel increase of circulating CXCL11 and CXCL10 in mixed cryoglobulinemia, while the proinflammatory cytokine IL-6 is associated with high serum Th2 chemokine CCL2
    Alessandro Antonelli
    Department of Clinical and Experimental Medicine, University of Pisa School of Medicine, Via Savi 10, 56126 Pisa, Italy
    Clin Rheumatol 32:1147-54. 2013
    ..001). This study demonstrates in MC + HCV high serum levels of (a) T-helper 1 chemokines, CXCL11 and CXCL10 (related to each other) and (b) proinflammatory cytokines IL-6 and CCL2 (related to each other)...
  21. ncbi request reprint Clinical and subclinical autoimmune thyroid disorders in systemic sclerosis
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Eur J Endocrinol 156:431-7. 2007
    ..Several studies have reported the association of systemic sclerosis (SSc) with thyroid autoimmune disorders, but most of them have neither an appropriate control group nor include a complete thyroid work-up...
  22. doi request reprint Novel pyrazolopyrimidine derivatives as tyrosine kinase inhibitors with antitumoral activity in vitro and in vivo in papillary dedifferentiated thyroid cancer
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma 67, I 56100, Pisa, Italy
    J Clin Endocrinol Metab 96:E288-96. 2011
    ..We have studied the antitumoral activity of two new pyrazolo[3,4-d]pyrimidine compounds (CLM3 and CLM29) in primary papillary dedifferentiated thyroid cancer (DePTC) cells...
  23. doi request reprint Prevalence of thyroid dysfunctions in systemic lupus erythematosus
    Alessandro Antonelli
    Metabolism Unit Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    Metabolism 59:896-900. 2010
    ..Subjects at high risk (women, positive AbTPOs, hypoechoic, and small thyroid) should have thyroid function follow-up and appropriate treatment in due course...
  24. doi request reprint CXCL10 and CCL2 chemokine serum levels in patients with hepatitis C associated with autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Interferon Cytokine Res 29:345-51. 2009
    ....
  25. ncbi request reprint Increase of interferon-gamma inducible alpha chemokine CXCL10 but not beta chemokine CCL2 serum levels in chronic autoimmune thyroiditis
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Eur J Endocrinol 152:171-7. 2005
    ..To measure serum levels of CXCL10 and CCL2 prototype chemokines of the two major subclass (CXC and CC) in patients with newly diagnosed chronic autoimmune thyroiditis (AT), and relate the findings to the clinical phenotype...
  26. ncbi request reprint Increased serum CXCL10 in Graves' disease or autoimmune thyroiditis is not associated with hyper- or hypothyroidism per se, but is specifically sustained by the autoimmune, inflammatory process
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
    Eur J Endocrinol 154:651-8. 2006
    ..Longitudinal assessment of sCXCL10 in autoimmune hypo- or hyperthyroidism has not yet been performed...
  27. doi request reprint Dysregulation of secretion of CXC alpha-chemokine CXCL10 in papillary thyroid cancer: modulation by peroxisome proliferator-activated receptor-gamma agonists
    Alessandro Antonelli
    Department of Internal Medicine, School of Medicine, University of Pisa, Pisa, Italy
    Endocr Relat Cancer 16:1299-311. 2009
    ..Moreover, TZDs inhibited CXCL10 secretion in TFC and stimulated it in PTCs. The effect of TZDs on CXCL10 was unrelated to the significant antiproliferative effect in PTCs...
  28. doi request reprint Primary cell cultures from anaplastic thyroid cancer obtained by fine-needle aspiration used for chemosensitivity tests
    Alessandro Antonelli
    Department of Internal Medicine, University Hospital of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 69:148-52. 2008
    ....
  29. ncbi request reprint Iodine-131 given for therapeutic purposes modulates differently interferon-gamma-inducible alpha-chemokine CXCL10 serum levels in patients with active Graves' disease or toxic nodular goiter
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine, Regional Center of Nuclear Medicine, University of Pisa Medical School, Via Roma, 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:1485-90. 2007
    ..Forty healthy subjects and 40 patients with autoimmune thyroiditis served as control groups...
  30. ncbi request reprint The presence of autoimmune thyroiditis in mixed cryoglobulinemia patients is associated with high levels of circulating interleukin-6, but not of tumor necrosis factor-alpha
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Italy
    Clin Exp Rheumatol 29:S17-22. 2011
    ..The aims of the study were to evaluate serum levels of IL-6 in MC+HCV patients and to correlate this parameter with the presence of AT and with circulating levels of TNF-α...
  31. ncbi request reprint Th1 and Th2 chemokine serum levels in systemic sclerosis in the presence or absence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Rheumatol 35:1809-11. 2008
    ..We evaluated contemporarily serum alpha and beta chemokines in patients with newly diagnosed systemic sclerosis (SSc) in the presence or absence of autoimmune thyroiditis (AT)...
  32. doi request reprint Monokine induced by interferon gamma (IFNgamma) (CXCL9) and IFNgamma inducible T-cell alpha-chemoattractant (CXCL11) involvement in Graves' disease and ophthalmopathy: modulation by peroxisome proliferator-activated receptor-gamma agonists
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 94:1803-9. 2009
    ..Peroxisome proliferator-activated receptor-gamma (PPARgamma) activation plays an inhibitory role in this process...
  33. doi request reprint CXCL9 and CXCL11 chemokines modulation by peroxisome proliferator-activated receptor-alpha agonists secretion in Graves' and normal thyrocytes
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
    J Clin Endocrinol Metab 95:E413-20. 2010
    ..However, until now, no data were present in the literature about the effect of PPARα activation on CXCL9 and CXCL11 chemokines in general or on secretion of these chemokines in thyroid cells...
  34. ncbi request reprint Thyroid cancer in HCV-related chronic hepatitis patients: a case-control study
    Alessandro Antonelli
    Metabolism Unit Department of Internal Medicine, University of Pisa, Italy
    Thyroid 17:447-51. 2007
    ....
  35. doi request reprint High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Am J Gastroenterol 103:2488-94. 2008
    ....
  36. doi request reprint High interleukin-6 and tumor necrosis factor-alpha serum levels in hepatitis C infection associated or not with mixed cryoglobulinemia
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma, 67, 56100, Pisa, Italy
    Clin Rheumatol 28:1179-85. 2009
    ..01). The study demonstrates high IL-6 and TNF-a serum levels in HCV-MC patients; moreover, IL-6 levels tended to be higher in HCV-MC patients in presence of active vasculitis...
  37. doi request reprint Increase of circulating CXCL9 and CXCL11 associated with euthyroid or subclinically hypothyroid autoimmune thyroiditis
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 96:1859-63. 2011
    ..Recently, CXCL9 and CXCL11 have been shown to be involved in autoimmune thyroid disorders; however, no data are present about CXCL9 and CXCL11 circulating levels in thyroid autoimmunity...
  38. doi request reprint High levels of circulating chemokine (C-X-C motif) ligand 11 are associated with euthyroid or subclinically hypothyroid autoimmune thyroiditis and with chemokine (C-X-C motif) ligand 10
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Interferon Cytokine Res 32:74-80. 2012
    ..These results underline the importance of a Th1 immune attack in the initiation of AT...
  39. doi request reprint High values of CXCL10 serum levels in patients with hepatitis C associated mixed cryoglobulinemia in presence or absence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, I 56100 Pisa, Italy
    Cytokine 42:137-43. 2008
    ..0001). In conclusion, our study is the first to demonstrate high serum levels of CXCL10 in MC and that CXCL10 in MC+AT patients are significantly higher compared to MC patients...
  40. ncbi request reprint Increase of interferon-gamma-inducible CXC chemokine CXCL10 serum levels in patients with active Graves' disease, and modulation by methimazole therapy
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Clin Endocrinol (Oxf) 64:189-95. 2006
    ....
  41. doi request reprint N-terminal pro-brain natriuretic peptide and tumor necrosis factor-alpha both are increased in patients with Hepatitis C
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Interferon Cytokine Res 30:359-63. 2010
    ..The increase of NT-proBNP may indicate the presence of a subclinical cardiac dysfunction. Further prospective studies quantifying symptoms and correlating these with echocardiographic parameters are needed to confirm this association...
  42. doi request reprint Circulating chemokine (CXC motif) ligand (CXCL)9 is increased in aggressive chronic autoimmune thyroiditis, in association with CXCL10
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56100 Pisa, Italy
    Cytokine 55:288-93. 2011
    ..A strong relation between circulating CXCL9 and CXCL10 has been first shown, underlining the importance of a T helper 1 immune attack in the initiation of AT...
  43. pmc High circulating N-terminal pro-brain natriuretic peptide and tumor necrosis factor-alpha in mixed cryoglobulinemia
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Pisa, 56100 Italy
    World J Gastroenterol 15:5074-9. 2009
    ..To evaluate serum levels of N-terminal pro-brain natriuretic peptide (NTproBNP) and tumor necrosis factor alpha (TNF-alpha) in a large series of patients with hepatitis C associated with mixed cryoglobulinemia (MC+HCV)...
  44. doi request reprint Serum levels of proinflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor alpha in mixed cryoglobulinemia
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Arthritis Rheum 60:3841-7. 2009
    ..This study was undertaken to evaluate serum levels of these cytokines in patients with HCV-MC...
  45. doi request reprint Thiazolidinediones and antiblastics in primary human anaplastic thyroid cancer cells
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, I 56100, Pisa, Italy
    Clin Endocrinol (Oxf) 70:946-53. 2009
    ..No study has evaluated the antiproliferative effects of thiazolidinediones and antiblastics in 'primary cultured human anaplastic thyroid cancer cells'...
  46. doi request reprint Thyroid uptake of 67Ga-citrate is associated with thyroid autoimmunity and hypothyroidism in patients with sarcoidosis
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine, University of Pisa and CNR Institute of Clinical Physiology, Via Roma, 67, 56126, Pisa, Italy
    Eur J Nucl Med Mol Imaging 36:137-43. 2009
    ..To evaluate the association of gallium-67 ((67)Ga)-citrate thyroid uptake with the presence of thyroid disorders in patients with sarcoidosis (S patients)...
  47. doi request reprint Serum concentrations of interleukin 1beta, CXCL10, and interferon-gamma in mixed cryoglobulinemia associated with hepatitis C infection
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, I 56100, Pisa, Italy
    J Rheumatol 37:91-7. 2010
    ..We evaluated serum levels of IL-1beta, IFN-gamma, and CXCL10 in a series of patients with hepatitis C-related MC (MC+HCV), and correlated these measurements with clinical disease features...
  48. doi request reprint Peroxisome proliferator-activated receptor α agonists modulate Th1 and Th2 chemokine secretion in normal thyrocytes and Graves' disease
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Exp Cell Res 317:1527-33. 2011
    ..Furthermore we first show that PPARα activators inhibit the secretion of CXCL10 and CCL2 in thyrocytes, suggesting that PPARα may be involved in the modulation of the immune response in the thyroid...
  49. ncbi request reprint Increase of CXC chemokine CXCL10 and CC chemokine CCL2 serum levels in normal ageing
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Cytokine 34:32-8. 2006
    ....
  50. doi request reprint Interleukin-1β, C-x-C motif ligand 10, and interferon-gamma serum levels in mixed cryoglobulinemia with or without autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Interferon Cytokine Res 30:835-42. 2010
    ..Moreover, a pathophysiological association between high circulating levels of IL-1β and CXCL10 has been suggested. A possible therapeutic role of the anti-IL-1 receptor antagonist (Anakirna) in MC remains to be evaluated...
  51. doi request reprint Evaluation of the sensitivity to chemotherapeutics or thiazolidinediones of primary anaplastic thyroid cancer cells obtained by fine-needle aspiration
    Alessandro Antonelli
    Department of Internal Medicine, School of Medicine, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy
    Eur J Endocrinol 159:283-91. 2008
    ..The possibility to obtain ANA from fine-needle aspiration (FNA-ANA) and to test their sensitivity to different drugs could increase the effectiveness of treatments and avoid unnecessary surgical procedures...
  52. ncbi request reprint Thyrotropin-stimulated serum thyroglobulin combined with neck ultrasonography has the highest sensitivity in monitoring differentiated thyroid carcinoma in children
    Alessandro Antonelli
    Department of Internal Medicine, Universita di Pisa, Pisa, Italy
    Surgery 140:1035-41; discussion 1041-2. 2006
  53. doi request reprint Dedifferentiated thyroid cancer: a therapeutic challenge
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma, 67, I 56100 Pisa, Italy
    Biomed Pharmacother 62:559-63. 2008
    ..In fact, chemosensitivity tests in primary tumoral cells may help in detecting responsive patients and in preventing the administration of inactive drugs to those unresponsive...
  54. doi request reprint Cytokines (interferon-γ and tumor necrosis factor-α)-induced nuclear factor-κB activation and chemokine (C-X-C motif) ligand 10 release in Graves disease and ophthalmopathy are modulated by pioglitazone
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, I 56100 Pisa, Italy
    Metabolism 60:277-83. 2011
    ..Future studies will be needed to verify if new targeted peroxisome proliferator-activated receptor-γ activators may be able to exert the anti-inflammatory effects without the risk of expanding retrobulbar fat mass...
  55. doi request reprint Interferon-alpha, -beta and -gamma induce CXCL9 and CXCL10 secretion by human thyrocytes: modulation by peroxisome proliferator-activated receptor-gamma agonists
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma 67, Pisa, Italy
    Cytokine 50:260-7. 2010
    ..Furthermore, PPARgamma activation partially inhibits this process...
  56. doi request reprint High values of alpha (CXCL10) and beta (CCL2) circulating chemokines in patients with psoriatic arthritis, in presence or absence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Autoimmunity 41:537-42. 2008
    ..Serum CXCL10 (alpha chemokine) levels in psoriatic arthritis patients are significantly higher in presence of AT...
  57. doi request reprint Thyroid cancer in systemic lupus erythematosus: a case-control study
    Alessandro Antonelli
    Departmentof Internal Medicine, University of Pisa, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 95:314-8. 2010
    ..Although advances in treatment have permitted patients with systemic lupus erythematosus (SLE) to live longer, the rates of several types of cancers in these patients appear to be increasing...
  58. doi request reprint Immunopathogenesis of HCV-related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemia
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine, University of Pisa, Italy
    Autoimmun Rev 8:18-23. 2008
    ..This process may lead to the appearance of thyroid autoimmune disorders or T2D in genetically predisposed subjects...
  59. pmc Cytokines and HCV-related disorders
    Poupak Fallahi
    Department of Internal Medicine, School of Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Clin Dev Immunol 2012:468107. 2012
    ..The therapeutical administration of cytokines such as IFN-alpha may result in viral clearance during persistent infection and reverts this process...
  60. doi request reprint Effect of telmisartan on QT interval variability and autonomic control in hypertensive patients with left ventricular hypertrophy
    Fabio Galetta
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56126 Pisa, Italy
    Biomed Pharmacother 64:516-20. 2010
    ..The aim of the study was to examine the effect of the antihypertensive AT1 receptors antagonist telmisartan on cardiovascular autonomic function and QT dispersion in hypertensive patients with LVH...
  61. ncbi request reprint Interferon-gamma-inducible alpha-chemokine CXCL10 involvement in Graves' ophthalmopathy: modulation by peroxisome proliferator-activated receptor-gamma agonists
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Rome 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 91:614-20. 2006
    ..Human thyrocytes in primary culture produce large amounts of CXCL10 when stimulated by interferon-gamma (IFNgamma) and TNFalpha...
  62. doi request reprint Alpha-chemokine CXCL10 and beta-chemokine CCL2 serum levels in patients with hepatitis C-associated cryoglobulinemia in the presence or absence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, I 56100 Pisa, Italy
    Metabolism 57:1270-7. 2008
    ..Future studies in larger series will be needed to evaluate the potential usefulness of serum CXCL10 and CCL2 determination as a prognostic marker in the follow-up of MC patients, also in relation to the presence of AT...
  63. doi request reprint High circulating levels of N-terminal pro-brain natriuretic peptide and interleukin 6 in patients with mixed cryoglobulinemia
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Med Virol 82:297-303. 2010
    ..07). The study revealed high levels of circulating NTproBNP and IL-6 in patients with mixed cryoglobulinemia and chronic HCV infection. The increase in NTproBNP could indicate the presence of a subclinical cardiac dysfunction...
  64. ncbi request reprint B-cells and mixed cryoglobulinemia
    Clodoveo Ferri
    Chair and Rheumatology Unit, Department of Internal Medicine, University of Modena and Reggio E, Medical School, Modena, Italy
    Autoimmun Rev 7:114-20. 2007
    ..The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients...
  65. doi request reprint Lobectomy versus total thyroidectomy in children with post-Chernobyl thyroid cancer: a 15 year follow-up
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Endocrine 40:432-6. 2011
    ..The results of this study favor total thyroidectomy as the initial treatment for thyroid cancer in children exposed to fallout radiation...
  66. ncbi request reprint Age-dependent changes in CXC chemokine ligand 10 serum levels in euthyroid subjects
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine, University of Pisa School of Medicine, Italy
    J Interferon Cytokine Res 25:547-52. 2005
    ..Results of this study, performed in healthy subjects on an age gradient, demonstrate an increase in serum CXCL10 with advancing age overall in females, supporting the hypothesis of enhanced Th1 immune responses in aging...
  67. ncbi request reprint Induction of chromatid-type aberrations in peripheral lymphocytes of hospital workers exposed to very low doses of radiation
    Michela Ballardin
    Dipartimento di Biologia, University of Pisa, Via San Giuseppe 22, Pisa 56100, Italy
    Mutat Res 626:61-8. 2007
    ..Moreover, we did not detect any significant difference due to radiation exposure when CR rates were considered separately for each of the three chromosomes in the probe cocktail...
  68. doi request reprint Intensive risk-adjusted follow-up with the CEA, TPA, CA19.9, and CA72.4 tumor marker panel and abdominal ultrasonography to diagnose operable colorectal cancer recurrences: effect on survival
    Andrea Nicolini
    Department of Internal Medicine, University of Pisa, Italy
    Arch Surg 145:1177-83. 2010
    ..Intensive risk-adjusted follow-up leads to improved resectability of tumor recurrences and better overall survival among patients who have undergone surgery for colorectal cancer...
  69. doi request reprint Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells
    Guido Bocci
    Division of Pharmacology, Department of Internal Medicine, University of Pisa, Via Roma, Pisa, Italy
    Biochem Pharmacol 81:1309-16. 2011
    ....
  70. ncbi request reprint Carotid integrated backscatter analysis in patients with subclinical hypothyroidism
    Ferdinando Franzoni
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, 56126 Pisa, Italy
    Clin Endocrinol (Oxf) 68:278-83. 2008
    ....
  71. ncbi request reprint Hepatitis C virus infection: evidence for an association with type 2 diabetes
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
    Diabetes Care 28:2548-50. 2005
  72. doi request reprint Endocrine manifestations of hepatitis C virus infection
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Nat Clin Pract Endocrinol Metab 5:26-34. 2009
    ..Nonetheless, additional studies will be necessary to elucidate fully all the mechanisms involved in HCV-related endocrine dysfunction...
  73. doi request reprint In vitro and in vivo study on the antioxidant activity of dexrazoxane
    Fabio Galetta
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56126 Pisa, Italy
    Biomed Pharmacother 64:259-63. 2010
    ..Aim of the present study was to assess the in vitro and in vivo antioxidant effects of dexrazoxane...
  74. ncbi request reprint Thyroid disorders in chronic hepatitis C virus infection
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Thyroid 16:563-72. 2006
    ..The abovementioned evidences seem sufficient to suggest careful thyroid monitoring during the follow-up of patients with HCV infection...
  75. ncbi request reprint Prevalence of hypothyroidism and Graves disease in sarcoidosis
    Alessandro Antonelli
    Metabolism Unit, University of Pisa, Italy
    Chest 130:526-32. 2006
    ..The aim of our study was to evaluate the prevalence of clinical and subclinical thyroid disorders in patients with S vs gender-matched and age-matched control subjects...
  76. doi request reprint Cardiovascular complications in patients with pheochromocytoma: a mini-review
    Fabio Galetta
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Biomed Pharmacother 64:505-9. 2010
    ..The recognition of early catecholamine-induced alterations in patients with pheochromocytoma, is important to prevent at least morbidity and mortality, before surgical treatment...
  77. ncbi request reprint High prevalence of thyroid autoimmunity and hypothyroidism in patients with psoriatic arthritis
    Alessandro Antonelli
    From the Department of Internal Medicine and the Rheumatology Unit, University of Pisa, and the Endocrinological Laboratory, Azienda Ospedaliera Pisana, Pisa, Italy
    J Rheumatol 33:2026-8. 2006
    ..To evaluate the prevalence of thyroid disorders in a group of patients with psoriatic arthritis (PsA)...
  78. doi request reprint Thyroid-associated ophthalmopathy and TSH receptor autoantibodies in nonmetastatic thyroid cancer after total thyroidectomy
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Pisa, Italy
    Am J Med Sci 336:288-90. 2008
    ..The parallel trend of antithyrotropin receptor autoantibodies titres and thyroid-associated ophthalmopathy suggests a role of these autoantibodies in the pathogenesis of thyroid-associated ophthalmopathy...
  79. doi request reprint Changes in heart rate variability and QT dispersion in patients with overt hypothyroidism
    Fabio Galetta
    Department of Internal Medicine, School of Medicine, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy
    Eur J Endocrinol 158:85-90. 2008
    ..The aim of the present study was to evaluate the effect of clinical hypothyroidism on cardiovascular autonomic function and ventricular repolarization...
  80. pmc New targeted molecular therapies for dedifferentiated thyroid cancer
    Alessandro Antonelli
    Department of Internal Medicine, Metabolism Unit, University of Pisa School of Medicine, Via Roma, 67, 56100 Pisa, Italy
    J Oncol 2010:921682. 2010
    ..Progress is being made toward effective targeted DeTC therapy. The possibility of testing the sensitivity of primary DeTC cells from each subject to different TKIs could increase the effectiveness of the treatment...
  81. ncbi request reprint Thyroid disorders in chronic hepatitis C
    Alessandro Antonelli
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Am J Med 117:10-3. 2004
    ..To explore the association of hepatitis C virus (HCV) infection with thyroid disorders...
  82. doi request reprint Clinicopathologic and molecular disease prognostication for papillary thyroid cancer
    Paolo Miccoli
    Department of Surgery, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Expert Rev Anticancer Ther 9:1261-75. 2009
    ..This article reviews the parameters used most commonly to differentiate low-risk PTCs from their more aggressive variants and describes some of the newest molecular therapies for this latter group of tumors...
  83. doi request reprint Chronic inflammation and mortality in haemodialysis: effect of different renal replacement therapies. Results from the RISCAVID study
    Vincenzo Panichi
    Internal Medicine Department, University of Pisa, Italy
    Nephrol Dial Transplant 23:2337-43. 2008
    ..235 million people). The aim of the study was to elucidate the relevance of traditional and non-traditional risk factors of mortality and morbidity in HD patients as well as the impact of different HD modalities...
  84. ncbi request reprint High levels of circulating CXC chemokine ligand 10 are associated with chronic autoimmune thyroiditis and hypothyroidism
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and National Research Center, Institute of Clinical Physiology, University of Pisa School of Medicine, Via Roma 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 89:5496-9. 2004
    ..We conclude that circulating CXCL10 is increased in patients with AT and is associated with hypothyroidism. CXCL10 may be regarded as a marker of a more aggressive thyroiditis leading to thyroid destruction...
  85. ncbi request reprint [Extrahepatic manifestations of hepatitis C virus: the thyroid disorders]
    Alessandro Antonelli
    Dipartimento di Medicina Interna, Universita di Pisa
    Recenti Prog Med 96:370-81. 2005
    ..These last data need to be confirmed by other studies, but seem to be sufficient to suggest careful thyroid monitoring during the follow-up of patients with HCV infection...
  86. ncbi request reprint Role of neck ultrasonography in the follow-up of children operated on for thyroid papillary cancer
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Italy
    Thyroid 13:479-84. 2003
    ..Furthermore, neck ultrasonography can pinpoint the anatomic site of the LNM...
  87. ncbi request reprint Effects on inflammatory and nutritional markers of haemodiafiltration with online regeneration of ultrafiltrate (HFR) vs online haemodiafiltration: a cross-over randomized multicentre trial
    Vincenzo Panichi
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Nephrol Dial Transplant 21:756-62. 2006
    ..The aim of this multicentre randomized cross-over study was to compare HFR to online HDF in terms of inflammatory and nutritional parameters...
  88. ncbi request reprint Effect of PPAR-gamma activation and inhibition on glucose-stimulated insulin release in INS-1e cells
    Eleonora Santini
    Department of Internal Medicine, Via Roma, 67, 56100, Pisa, Italy
    Diabetes 53:S79-83. 2004
    ..0001 for both effects). In conclusion, INS-1e cells display a PPAR-gamma tone that is symmetrically modulated and competitively stimulated by oleate...
  89. ncbi request reprint New trends in the treatment of undifferentiated carcinomas of the thyroid
    Paolo Miccoli
    Department of Surgery, University of Pisa, Pisa, Italy
    Langenbecks Arch Surg 392:397-404. 2007
    ..ATC is not only the most lethal disease in the field of endocrine surgery but also one of the most aggressive tumours characterized by an almost invariable fatal outcome, which only very rarely exceeds a 1-year course...
  90. ncbi request reprint Mixed cryoglobulinemia: demographic, clinical, and serologic features and survival in 231 patients
    Clodoveo Ferri
    Department of Internal Medicine, University of Pisa Medical School, Pisa, Italy
    Semin Arthritis Rheum 33:355-74. 2004
    ..MC is characterized by multiple organ involvement, mainly skin, liver, renal, peripheral nerves, and less frequently by widespread vasculitis and cancer...