A Antonelli

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. doi request reprint Parallel increase of circulating CXCL11 and CXCL10 in mixed cryoglobulinemia, while the proinflammatory cytokine IL-6 is associated with high serum Th2 chemokine CCL2
    Alessandro Antonelli
    Department of Clinical and Experimental Medicine, University of Pisa School of Medicine, Via Savi 10, 56126 Pisa, Italy
    Clin Rheumatol 32:1147-54. 2013
  2. doi request reprint IFN-γ and TNF-α induce a different modulation of interleukin-6 in systemic sclerosis fibroblasts compared to healthy controls
    A Antonelli
    Department of Internal Medicine, Metabolism Unit, University of Pisa School of Medicine, Pisa, Italy
    Scand J Rheumatol 40:453-6. 2011
  3. doi request reprint Dedifferentiated thyroid cancer: a therapeutic challenge
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma, 67, I 56100 Pisa, Italy
    Biomed Pharmacother 62:559-63. 2008
  4. doi request reprint CXCL10 and CCL2 serum levels in patients with mixed cryoglobulinaemia and hepatitis C
    A Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Dig Liver Dis 41:42-8. 2009
  5. doi request reprint Thiazolidinediones and antiblastics in primary human anaplastic thyroid cancer cells
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, I 56100, Pisa, Italy
    Clin Endocrinol (Oxf) 70:946-53. 2009
  6. doi request reprint Thyroid uptake of 67Ga-citrate is associated with thyroid autoimmunity and hypothyroidism in patients with sarcoidosis
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine, University of Pisa and CNR Institute of Clinical Physiology, Via Roma, 67, 56126, Pisa, Italy
    Eur J Nucl Med Mol Imaging 36:137-43. 2009
  7. doi request reprint High values of alpha (CXCL10) and beta (CCL2) circulating chemokines in patients with psoriatic arthritis, in presence or absence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Autoimmunity 41:537-42. 2008
  8. doi request reprint Serum Th1 (CXCL10) and Th2 (CCL2) chemokine levels in children with newly diagnosed Type 1 diabetes: a longitudinal study
    A Antonelli
    Department of Internal Medicine and Metabolism Unit, CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Diabet Med 25:1349-53. 2008
  9. doi request reprint Endocrine manifestations of hepatitis C virus infection
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Nat Clin Pract Endocrinol Metab 5:26-34. 2009
  10. ncbi request reprint Th1 and Th2 chemokine serum levels in systemic sclerosis in the presence or absence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Rheumatol 35:1809-11. 2008

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. doi request reprint Parallel increase of circulating CXCL11 and CXCL10 in mixed cryoglobulinemia, while the proinflammatory cytokine IL-6 is associated with high serum Th2 chemokine CCL2
    Alessandro Antonelli
    Department of Clinical and Experimental Medicine, University of Pisa School of Medicine, Via Savi 10, 56126 Pisa, Italy
    Clin Rheumatol 32:1147-54. 2013
    ..001). This study demonstrates in MC + HCV high serum levels of (a) T-helper 1 chemokines, CXCL11 and CXCL10 (related to each other) and (b) proinflammatory cytokines IL-6 and CCL2 (related to each other)...
  2. doi request reprint IFN-γ and TNF-α induce a different modulation of interleukin-6 in systemic sclerosis fibroblasts compared to healthy controls
    A Antonelli
    Department of Internal Medicine, Metabolism Unit, University of Pisa School of Medicine, Pisa, Italy
    Scand J Rheumatol 40:453-6. 2011
    ....
  3. doi request reprint Dedifferentiated thyroid cancer: a therapeutic challenge
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma, 67, I 56100 Pisa, Italy
    Biomed Pharmacother 62:559-63. 2008
    ..In fact, chemosensitivity tests in primary tumoral cells may help in detecting responsive patients and in preventing the administration of inactive drugs to those unresponsive...
  4. doi request reprint CXCL10 and CCL2 serum levels in patients with mixed cryoglobulinaemia and hepatitis C
    A Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Dig Liver Dis 41:42-8. 2009
    ..No study evaluates serum levels of CXCL10 and CCL2 chemokines in patients with hepatitis C associated mixed cryoglobulinaemia...
  5. doi request reprint Thiazolidinediones and antiblastics in primary human anaplastic thyroid cancer cells
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, I 56100, Pisa, Italy
    Clin Endocrinol (Oxf) 70:946-53. 2009
    ..No study has evaluated the antiproliferative effects of thiazolidinediones and antiblastics in 'primary cultured human anaplastic thyroid cancer cells'...
  6. doi request reprint Thyroid uptake of 67Ga-citrate is associated with thyroid autoimmunity and hypothyroidism in patients with sarcoidosis
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine, University of Pisa and CNR Institute of Clinical Physiology, Via Roma, 67, 56126, Pisa, Italy
    Eur J Nucl Med Mol Imaging 36:137-43. 2009
    ..To evaluate the association of gallium-67 ((67)Ga)-citrate thyroid uptake with the presence of thyroid disorders in patients with sarcoidosis (S patients)...
  7. doi request reprint High values of alpha (CXCL10) and beta (CCL2) circulating chemokines in patients with psoriatic arthritis, in presence or absence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Autoimmunity 41:537-42. 2008
    ..Serum CXCL10 (alpha chemokine) levels in psoriatic arthritis patients are significantly higher in presence of AT...
  8. doi request reprint Serum Th1 (CXCL10) and Th2 (CCL2) chemokine levels in children with newly diagnosed Type 1 diabetes: a longitudinal study
    A Antonelli
    Department of Internal Medicine and Metabolism Unit, CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Diabet Med 25:1349-53. 2008
    ..The aim of this study was to investigate whether circulating chemokines involved in T-helper 1 (CXCL10) and T-helper 2 (CCL2) autoimmunity are increased in children with Type 1 diabetes at onset and follow-up...
  9. doi request reprint Endocrine manifestations of hepatitis C virus infection
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Nat Clin Pract Endocrinol Metab 5:26-34. 2009
    ..Nonetheless, additional studies will be necessary to elucidate fully all the mechanisms involved in HCV-related endocrine dysfunction...
  10. ncbi request reprint Th1 and Th2 chemokine serum levels in systemic sclerosis in the presence or absence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Rheumatol 35:1809-11. 2008
    ..We evaluated contemporarily serum alpha and beta chemokines in patients with newly diagnosed systemic sclerosis (SSc) in the presence or absence of autoimmune thyroiditis (AT)...
  11. doi request reprint Immunopathogenesis of HCV-related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemia
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine, University of Pisa, Italy
    Autoimmun Rev 8:18-23. 2008
    ..This process may lead to the appearance of thyroid autoimmune disorders or T2D in genetically predisposed subjects...
  12. ncbi request reprint Iodine-131 given for therapeutic purposes modulates differently interferon-gamma-inducible alpha-chemokine CXCL10 serum levels in patients with active Graves' disease or toxic nodular goiter
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine, Regional Center of Nuclear Medicine, University of Pisa Medical School, Via Roma, 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:1485-90. 2007
    ..Forty healthy subjects and 40 patients with autoimmune thyroiditis served as control groups...
  13. ncbi request reprint Clinical and subclinical autoimmune thyroid disorders in systemic sclerosis
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Eur J Endocrinol 156:431-7. 2007
    ..Several studies have reported the association of systemic sclerosis (SSc) with thyroid autoimmune disorders, but most of them have neither an appropriate control group nor include a complete thyroid work-up...
  14. ncbi request reprint Thyroid cancer in HCV-related chronic hepatitis patients: a case-control study
    Alessandro Antonelli
    Metabolism Unit Department of Internal Medicine, University of Pisa, Italy
    Thyroid 17:447-51. 2007
    ....
  15. ncbi request reprint CXCL10 (alpha) and CCL2 (beta) chemokines in systemic sclerosis--a longitudinal study
    A Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
    Rheumatology (Oxford) 47:45-9. 2008
    ..To measure serum levels of CXCL10 and CCL2 chemokines in patients with SSc, and relate the findings to clinical phenotype and disease progression...
  16. doi request reprint Primary cell cultures from anaplastic thyroid cancer obtained by fine-needle aspiration used for chemosensitivity tests
    Alessandro Antonelli
    Department of Internal Medicine, University Hospital of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 69:148-52. 2008
    ....
  17. doi request reprint High values of CXCL10 serum levels in patients with hepatitis C associated mixed cryoglobulinemia in presence or absence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, I 56100 Pisa, Italy
    Cytokine 42:137-43. 2008
    ..0001). In conclusion, our study is the first to demonstrate high serum levels of CXCL10 in MC and that CXCL10 in MC+AT patients are significantly higher compared to MC patients...
  18. doi request reprint Evaluation of the sensitivity to chemotherapeutics or thiazolidinediones of primary anaplastic thyroid cancer cells obtained by fine-needle aspiration
    Alessandro Antonelli
    Department of Internal Medicine, School of Medicine, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy
    Eur J Endocrinol 159:283-91. 2008
    ..The possibility to obtain ANA from fine-needle aspiration (FNA-ANA) and to test their sensitivity to different drugs could increase the effectiveness of treatments and avoid unnecessary surgical procedures...
  19. doi request reprint Alpha-chemokine CXCL10 and beta-chemokine CCL2 serum levels in patients with hepatitis C-associated cryoglobulinemia in the presence or absence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, I 56100 Pisa, Italy
    Metabolism 57:1270-7. 2008
    ..Future studies in larger series will be needed to evaluate the potential usefulness of serum CXCL10 and CCL2 determination as a prognostic marker in the follow-up of MC patients, also in relation to the presence of AT...
  20. doi request reprint Monokine induced by interferon gamma (IFNgamma) (CXCL9) and IFNgamma inducible T-cell alpha-chemoattractant (CXCL11) involvement in Graves' disease and ophthalmopathy: modulation by peroxisome proliferator-activated receptor-gamma agonists
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 94:1803-9. 2009
    ..Peroxisome proliferator-activated receptor-gamma (PPARgamma) activation plays an inhibitory role in this process...
  21. doi request reprint CXCL10 and CCL2 chemokine serum levels in patients with hepatitis C associated with autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Interferon Cytokine Res 29:345-51. 2009
    ....
  22. doi request reprint Circulating chemokine (CXC motif) ligand (CXCL)9 is increased in aggressive chronic autoimmune thyroiditis, in association with CXCL10
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56100 Pisa, Italy
    Cytokine 55:288-93. 2011
    ..A strong relation between circulating CXCL9 and CXCL10 has been first shown, underlining the importance of a T helper 1 immune attack in the initiation of AT...
  23. doi request reprint Peroxisome proliferator-activated receptor α agonists modulate Th1 and Th2 chemokine secretion in normal thyrocytes and Graves' disease
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Exp Cell Res 317:1527-33. 2011
    ..Furthermore we first show that PPARα activators inhibit the secretion of CXCL10 and CCL2 in thyrocytes, suggesting that PPARα may be involved in the modulation of the immune response in the thyroid...
  24. doi request reprint Increase of circulating CXCL9 and CXCL11 associated with euthyroid or subclinically hypothyroid autoimmune thyroiditis
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 96:1859-63. 2011
    ..Recently, CXCL9 and CXCL11 have been shown to be involved in autoimmune thyroid disorders; however, no data are present about CXCL9 and CXCL11 circulating levels in thyroid autoimmunity...
  25. ncbi request reprint The presence of autoimmune thyroiditis in mixed cryoglobulinemia patients is associated with high levels of circulating interleukin-6, but not of tumor necrosis factor-alpha
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Italy
    Clin Exp Rheumatol 29:S17-22. 2011
    ..The aims of the study were to evaluate serum levels of IL-6 in MC+HCV patients and to correlate this parameter with the presence of AT and with circulating levels of TNF-α...
  26. doi request reprint Novel pyrazolopyrimidine derivatives as tyrosine kinase inhibitors with antitumoral activity in vitro and in vivo in papillary dedifferentiated thyroid cancer
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma 67, I 56100, Pisa, Italy
    J Clin Endocrinol Metab 96:E288-96. 2011
    ..We have studied the antitumoral activity of two new pyrazolo[3,4-d]pyrimidine compounds (CLM3 and CLM29) in primary papillary dedifferentiated thyroid cancer (DePTC) cells...
  27. doi request reprint Interleukin-1β, C-x-C motif ligand 10, and interferon-gamma serum levels in mixed cryoglobulinemia with or without autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Interferon Cytokine Res 30:835-42. 2010
    ..Moreover, a pathophysiological association between high circulating levels of IL-1β and CXCL10 has been suggested. A possible therapeutic role of the anti-IL-1 receptor antagonist (Anakirna) in MC remains to be evaluated...
  28. doi request reprint CXCL9 and CXCL11 chemokines modulation by peroxisome proliferator-activated receptor-alpha agonists secretion in Graves' and normal thyrocytes
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
    J Clin Endocrinol Metab 95:E413-20. 2010
    ..However, until now, no data were present in the literature about the effect of PPARα activation on CXCL9 and CXCL11 chemokines in general or on secretion of these chemokines in thyroid cells...
  29. doi request reprint Interferon-alpha, -beta and -gamma induce CXCL9 and CXCL10 secretion by human thyrocytes: modulation by peroxisome proliferator-activated receptor-gamma agonists
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma 67, Pisa, Italy
    Cytokine 50:260-7. 2010
    ..Furthermore, PPARgamma activation partially inhibits this process...
  30. doi request reprint Cytokines (interferon-γ and tumor necrosis factor-α)-induced nuclear factor-κB activation and chemokine (C-X-C motif) ligand 10 release in Graves disease and ophthalmopathy are modulated by pioglitazone
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, I 56100 Pisa, Italy
    Metabolism 60:277-83. 2011
    ..Future studies will be needed to verify if new targeted peroxisome proliferator-activated receptor-γ activators may be able to exert the anti-inflammatory effects without the risk of expanding retrobulbar fat mass...
  31. doi request reprint N-terminal pro-brain natriuretic peptide and tumor necrosis factor-alpha both are increased in patients with Hepatitis C
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Interferon Cytokine Res 30:359-63. 2010
    ..The increase of NT-proBNP may indicate the presence of a subclinical cardiac dysfunction. Further prospective studies quantifying symptoms and correlating these with echocardiographic parameters are needed to confirm this association...
  32. doi request reprint High circulating levels of N-terminal pro-brain natriuretic peptide and interleukin 6 in patients with mixed cryoglobulinemia
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Med Virol 82:297-303. 2010
    ..07). The study revealed high levels of circulating NTproBNP and IL-6 in patients with mixed cryoglobulinemia and chronic HCV infection. The increase in NTproBNP could indicate the presence of a subclinical cardiac dysfunction...
  33. doi request reprint Prevalence of thyroid dysfunctions in systemic lupus erythematosus
    Alessandro Antonelli
    Metabolism Unit Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    Metabolism 59:896-900. 2010
    ..Subjects at high risk (women, positive AbTPOs, hypoechoic, and small thyroid) should have thyroid function follow-up and appropriate treatment in due course...
  34. doi request reprint Serum levels of proinflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor alpha in mixed cryoglobulinemia
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Arthritis Rheum 60:3841-7. 2009
    ..This study was undertaken to evaluate serum levels of these cytokines in patients with HCV-MC...
  35. doi request reprint Serum concentrations of interleukin 1beta, CXCL10, and interferon-gamma in mixed cryoglobulinemia associated with hepatitis C infection
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, I 56100, Pisa, Italy
    J Rheumatol 37:91-7. 2010
    ..We evaluated serum levels of IL-1beta, IFN-gamma, and CXCL10 in a series of patients with hepatitis C-related MC (MC+HCV), and correlated these measurements with clinical disease features...
  36. doi request reprint Thyroid cancer in systemic lupus erythematosus: a case-control study
    Alessandro Antonelli
    Departmentof Internal Medicine, University of Pisa, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 95:314-8. 2010
    ..Although advances in treatment have permitted patients with systemic lupus erythematosus (SLE) to live longer, the rates of several types of cancers in these patients appear to be increasing...
  37. doi request reprint Dysregulation of secretion of CXC alpha-chemokine CXCL10 in papillary thyroid cancer: modulation by peroxisome proliferator-activated receptor-gamma agonists
    Alessandro Antonelli
    Department of Internal Medicine, School of Medicine, University of Pisa, Pisa, Italy
    Endocr Relat Cancer 16:1299-311. 2009
    ..Moreover, TZDs inhibited CXCL10 secretion in TFC and stimulated it in PTCs. The effect of TZDs on CXCL10 was unrelated to the significant antiproliferative effect in PTCs...
  38. doi request reprint High interleukin-6 and tumor necrosis factor-alpha serum levels in hepatitis C infection associated or not with mixed cryoglobulinemia
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma, 67, 56100, Pisa, Italy
    Clin Rheumatol 28:1179-85. 2009
    ..01). The study demonstrates high IL-6 and TNF-a serum levels in HCV-MC patients; moreover, IL-6 levels tended to be higher in HCV-MC patients in presence of active vasculitis...
  39. doi request reprint Thyroid-associated ophthalmopathy and TSH receptor autoantibodies in nonmetastatic thyroid cancer after total thyroidectomy
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Pisa, Italy
    Am J Med Sci 336:288-90. 2008
    ..The parallel trend of antithyrotropin receptor autoantibodies titres and thyroid-associated ophthalmopathy suggests a role of these autoantibodies in the pathogenesis of thyroid-associated ophthalmopathy...
  40. ncbi request reprint CD38 autoimmunity: recent advances and relevance to human diabetes
    A Antonelli
    Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    J Endocrinol Invest 27:695-707. 2004
    ..More information, however, is necessary to gauge the role of CD38 autoimmunity in the context of the natural history of human Type 1 or Type 2 diabetes...
  41. ncbi request reprint Prevalence of hypothyroidism and Graves disease in sarcoidosis
    Alessandro Antonelli
    Metabolism Unit, University of Pisa, Italy
    Chest 130:526-32. 2006
    ..The aim of our study was to evaluate the prevalence of clinical and subclinical thyroid disorders in patients with S vs gender-matched and age-matched control subjects...
  42. ncbi request reprint Thyroid disorders in chronic hepatitis C virus infection
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Thyroid 16:563-72. 2006
    ..The abovementioned evidences seem sufficient to suggest careful thyroid monitoring during the follow-up of patients with HCV infection...
  43. ncbi request reprint Increase of interferon-gamma inducible alpha chemokine CXCL10 but not beta chemokine CCL2 serum levels in chronic autoimmune thyroiditis
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Eur J Endocrinol 152:171-7. 2005
    ..To measure serum levels of CXCL10 and CCL2 prototype chemokines of the two major subclass (CXC and CC) in patients with newly diagnosed chronic autoimmune thyroiditis (AT), and relate the findings to the clinical phenotype...
  44. ncbi request reprint Age-dependent changes in CXC chemokine ligand 10 serum levels in euthyroid subjects
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine, University of Pisa School of Medicine, Italy
    J Interferon Cytokine Res 25:547-52. 2005
    ..Results of this study, performed in healthy subjects on an age gradient, demonstrate an increase in serum CXCL10 with advancing age overall in females, supporting the hypothesis of enhanced Th1 immune responses in aging...
  45. ncbi request reprint Serum levels of the interferon-gamma-inducible alpha chemokine CXCL10 in patients with active Graves' disease, and modulation by methimazole therapy and thyroidectomy
    A Antonelli
    Metabolism Unit, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Br J Surg 93:1226-31. 2006
    ..The aim of this study was to measure serum levels of CXCL10 in relation to thyroid function and treatment...
  46. ncbi request reprint Hepatitis C virus infection: evidence for an association with type 2 diabetes
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
    Diabetes Care 28:2548-50. 2005
  47. ncbi request reprint Increase of CXC chemokine CXCL10 and CC chemokine CCL2 serum levels in normal ageing
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Cytokine 34:32-8. 2006
    ....
  48. ncbi request reprint Increased serum CXCL10 in Graves' disease or autoimmune thyroiditis is not associated with hyper- or hypothyroidism per se, but is specifically sustained by the autoimmune, inflammatory process
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
    Eur J Endocrinol 154:651-8. 2006
    ..Longitudinal assessment of sCXCL10 in autoimmune hypo- or hyperthyroidism has not yet been performed...
  49. ncbi request reprint [Extrahepatic manifestations of hepatitis C virus: the thyroid disorders]
    Alessandro Antonelli
    Dipartimento di Medicina Interna, Universita di Pisa
    Recenti Prog Med 96:370-81. 2005
    ..These last data need to be confirmed by other studies, but seem to be sufficient to suggest careful thyroid monitoring during the follow-up of patients with HCV infection...
  50. ncbi request reprint Interferon-gamma-inducible alpha-chemokine CXCL10 involvement in Graves' ophthalmopathy: modulation by peroxisome proliferator-activated receptor-gamma agonists
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Rome 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 91:614-20. 2006
    ..Human thyrocytes in primary culture produce large amounts of CXCL10 when stimulated by interferon-gamma (IFNgamma) and TNFalpha...
  51. ncbi request reprint High levels of circulating CXC chemokine ligand 10 are associated with chronic autoimmune thyroiditis and hypothyroidism
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and National Research Center, Institute of Clinical Physiology, University of Pisa School of Medicine, Via Roma 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 89:5496-9. 2004
    ..We conclude that circulating CXCL10 is increased in patients with AT and is associated with hypothyroidism. CXCL10 may be regarded as a marker of a more aggressive thyroiditis leading to thyroid destruction...
  52. ncbi request reprint Thyroid involvement in patients with overt HCV-related mixed cryoglobulinaemia
    A Antonelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100, Pisa, Italy
    QJM 97:499-506. 2004
    ..The prevalence of thyroid disorders in MC has not yet been studied...
  53. pmc High circulating N-terminal pro-brain natriuretic peptide and tumor necrosis factor-alpha in mixed cryoglobulinemia
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Pisa, 56100 Italy
    World J Gastroenterol 15:5074-9. 2009
    ..To evaluate serum levels of N-terminal pro-brain natriuretic peptide (NTproBNP) and tumor necrosis factor alpha (TNF-alpha) in a large series of patients with hepatitis C associated with mixed cryoglobulinemia (MC+HCV)...
  54. ncbi request reprint Thyroid disorders in chronic hepatitis C
    Alessandro Antonelli
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Am J Med 117:10-3. 2004
    ..To explore the association of hepatitis C virus (HCV) infection with thyroid disorders...
  55. ncbi request reprint Thyroid cancer in HCV-related mixed cryoglobulinemia patients
    A Antonelli
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Clin Exp Rheumatol 20:693-6. 2002
    ..The prevalence of thyroid cancer in a series of unselected HCV-related mixed cryoglobulinemic patients was investigated in comparison with a control group...
  56. ncbi request reprint Role of neck ultrasonography in the follow-up of children operated on for thyroid papillary cancer
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Italy
    Thyroid 13:479-84. 2003
    ..Furthermore, neck ultrasonography can pinpoint the anatomic site of the LNM...
  57. ncbi request reprint Type 2 diabetes in hepatitis C-related mixed cryoglobulinaemia patients
    A Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Rheumatology (Oxford) 43:238-40. 2004
    ..A possible link between HCV infection and type 2 diabetes has been suggested. This study evaluated the prevalence and clinical phenotype of diabetes in MC-HCV+ patients...
  58. pmc Anti-CD38 autoimmunity in patients with chronic autoimmune thyroiditis or Graves' disease
    A Antonelli
    Metabolism Unit, CNR Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, Italy
    Clin Exp Immunol 126:426-31. 2001
    ..Anti-CD38 autoantibodies are a new autoimmune marker in chronic autoimmune thyroiditis and Graves' disease. The specific role of CD38 and its autoantibodies in the modulation of thyroid cell function or growth remains to be investigated...
  59. ncbi request reprint High circulating chemokines (C-X-C motif) ligand 9, and (C-X-C motif) ligand 11, in hepatitis C-associated cryoglobulinemia
    A Antonelli
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    Int J Immunopathol Pharmacol 26:49-57. 2013
    ..Future studies on a larger cohort of patients are needed to evaluate the relevance of serum CXCL9 and CXCL11 determination as clinico-prognostic marker of MC+HCV...
  60. ncbi request reprint High values of Th1 (CXCL10) and Th2 (CCL2) chemokines in patients with psoriatic arthtritis
    A Antonelli
    Department of Internal Medicine, University of Pisa, Italy
    Clin Exp Rheumatol 27:22-7. 2009
    ..To evaluate serum levels of CXCL10 and CCL2 in a large series of PsA patients, and to relate chemokines levels to the clinical phenotype of these patients...
  61. ncbi request reprint HCV and cryoglobulinemic vasculitis
    C Ferri
    Dipartimento di Medicina Interna, Reumatologia, Universita di Pisa, Italy
    Cleve Clin J Med 69:SII20-3. 2002
  62. ncbi request reprint Human anti-CD38 autoantibodies raise intracellular calcium and stimulate insulin release in human pancreatic islets
    A Antonelli
    Consiglio Nazionale delle Richerche Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, Italy
    Diabetes 50:985-91. 2001
    ..002). We conclude that human anti-CD38 autoantibodies with agonistic properties on the CD38 effector system occur in nature; in human islets, their [Ca2+]i-mobilizing activity is coupled with the ability to stimulate insulin release...
  63. ncbi request reprint Cancer stem cells: perspectives of new therapeutical approaches for breast cancer
    A Nicolini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Front Biosci (Schol Ed) 3:1486-99. 2011
    ..Here all these novel approaches related to breast cancer stem cells are described...
  64. doi request reprint High levels of circulating N-terminal pro-brain natriuretic peptide in patients with hepatitis C
    A Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Viral Hepat 17:851-3. 2010
    ..The increase of NT-proBNP may indicate the presence of a sub-clinical cardiac dysfunction. Further prospective studies quantifying these symptoms in correlation with echocardiography are needed to confirm this association...
  65. doi request reprint Changes in autonomic regulation and ventricular repolarization induced by subclinical hyperthyroidism
    F Galetta
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Biomed Pharmacother 64:546-9. 2010
    ..The aim of the present study was to evaluate the effect of subclinical hyperthyroidism (SHT) on cardiovascular autonomic function and ventricular repolarization...
  66. ncbi request reprint Autoimmunity to CD38 and GAD in Type I and Type II diabetes: CD38 and HLA genotypes and clinical phenotypes
    A Antonelli
    Department of Internal Medicine and Metabolism Unit of the CNR Institute of Clinical Physiology, University of Pisa, Italy
    Diabetologia 45:1298-306. 2002
    ..We tested whether this new form of autoimmunity, (i). overlaps with anti-GAD autoimmunity, (ii). identifies an insulin-deficient phenotype, (iii). is under the influence of genetic factors...
  67. ncbi request reprint Effect of L-thyroxine treatment on left ventricular function in subclinical hypothyroidism
    F Franzoni
    Department of Internal Medicine, University of Pisa, Via Roma 67, Pisa, Italy
    Biomed Pharmacother 60:431-6. 2006
    ..L-T4 replacement therapy should be advised for these patients with the aim to correct preclinical cardiac dysfunction and prevent the development of clinically significant myocardial dysfunction...
  68. doi request reprint High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Am J Gastroenterol 103:2488-94. 2008
    ....
  69. ncbi request reprint High prevalence of thyroid autoimmunity and hypothyroidism in patients with psoriatic arthritis
    Alessandro Antonelli
    From the Department of Internal Medicine and the Rheumatology Unit, University of Pisa, and the Endocrinological Laboratory, Azienda Ospedaliera Pisana, Pisa, Italy
    J Rheumatol 33:2026-8. 2006
    ..To evaluate the prevalence of thyroid disorders in a group of patients with psoriatic arthritis (PsA)...
  70. ncbi request reprint Thyrotropin-stimulated serum thyroglobulin combined with neck ultrasonography has the highest sensitivity in monitoring differentiated thyroid carcinoma in children
    Alessandro Antonelli
    Department of Internal Medicine, Universita di Pisa, Pisa, Italy
    Surgery 140:1035-41; discussion 1041-2. 2006
  71. ncbi request reprint B-cells and mixed cryoglobulinemia
    Clodoveo Ferri
    Chair and Rheumatology Unit, Department of Internal Medicine, University of Modena and Reggio E, Medical School, Modena, Italy
    Autoimmun Rev 7:114-20. 2007
    ..The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients...
  72. ncbi request reprint Percutaneous large-needle aspiration biopsy histology of palpable thyroid nodules: technical and diagnostic performance
    A Carpi
    Department of Reproduction and Ageing, University Hospital, Pisa, Italy
    Histopathology 51:249-57. 2007
    ..To report original and review existing data on safety and performance of large-needle aspiration biopsy (LNAB) histology in the preoperative selection of palpable thyroid nodule...
  73. ncbi request reprint Heart rate variability and QT dispersion in patients with subclinical hypothyroidism
    F Galetta
    Department of Internal Medicine, University of Pisa, Via Roma, 67, Pisa, Italy
    Biomed Pharmacother 60:425-30. 2006
    ..The aim of the present study was to evaluate the dispersion of QT interval, i.e. an index of inhomogeneity of repolarization, and heart rate variability (HRV), i.e. a measure of cardiac autonomic modulation, in SH patients...
  74. doi request reprint Spontaneous and bleomycin-induced chromosome damage in non cancer thyroid patients
    R Scarpato
    Dipartimento di Biologia, University of Pisa, via Derna 1, 56100 Pisa, Italy
    Eur J Clin Invest 39:1091-7. 2009
    ..Individual susceptibility to DNA damage, considered as a risk factor for cancer, can be also evaluated using the bleomycin (BLM) sensitivity test...
  75. ncbi request reprint Stem cells: their role in breast cancer development and resistance to treatment
    A Nicolini
    Department of Internal Medicine, University of Pisa, Italy
    Curr Pharm Biotechnol 12:196-205. 2011
    ..The reasons for CSC resistance to chemotherapy, hormone therapy and radiotherapy also have been examined and they opened new scenarios for cancer therapy...
  76. doi request reprint Cardiac remodeling in patients with primary aldosteronism
    F Galetta
    Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    J Endocrinol Invest 32:739-45. 2009
    ..To evaluate the morpho-functional changes of the myocardium in patients with primary aldosteronism (PA)...
  77. ncbi request reprint Cytokines in the management of high risk or advanced breast cancer: an update and expectation
    A Carpi
    Department of Reproduction and Ageing, 56126 Pisa, Italy
    Curr Cancer Drug Targets 9:888-903. 2009
    ..If this immunotherapy prolongs survival of endocrine dependent metastatic breast cancer patients, IL-2 and IFNbeta can also be evaluated as adjuvant treatment of patients with positive estrogen receptors...
  78. doi request reprint Thyroid fine needle aspiration: how to improve clinicians' confidence and performance with the technique
    A Carpi
    Department of Reproduction and Ageing, University Hospital, Ospedale Santa Chiara, Via Roma, 67, 56126 Pisa, Italy
    Cancer Lett 264:163-71. 2008
    ..Therefore, we propose that clinical practice guidelines reflect these adjuvant techniques to thyroid FNA in order to improve selection criteria for thyroid nodule surgery...
  79. ncbi request reprint Effects on inflammatory and nutritional markers of haemodiafiltration with online regeneration of ultrafiltrate (HFR) vs online haemodiafiltration: a cross-over randomized multicentre trial
    Vincenzo Panichi
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Nephrol Dial Transplant 21:756-62. 2006
    ..The aim of this multicentre randomized cross-over study was to compare HFR to online HDF in terms of inflammatory and nutritional parameters...
  80. doi request reprint Effect of telmisartan on QT interval variability and autonomic control in hypertensive patients with left ventricular hypertrophy
    Fabio Galetta
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56126 Pisa, Italy
    Biomed Pharmacother 64:516-20. 2010
    ..The aim of the study was to examine the effect of the antihypertensive AT1 receptors antagonist telmisartan on cardiovascular autonomic function and QT dispersion in hypertensive patients with LVH...
  81. doi request reprint Chronic inflammation and mortality in haemodialysis: effect of different renal replacement therapies. Results from the RISCAVID study
    Vincenzo Panichi
    Internal Medicine Department, University of Pisa, Italy
    Nephrol Dial Transplant 23:2337-43. 2008
    ..235 million people). The aim of the study was to elucidate the relevance of traditional and non-traditional risk factors of mortality and morbidity in HD patients as well as the impact of different HD modalities...
  82. ncbi request reprint Increase of interferon-gamma-inducible CXC chemokine CXCL10 serum levels in patients with active Graves' disease, and modulation by methimazole therapy
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Clin Endocrinol (Oxf) 64:189-95. 2006
    ....
  83. doi request reprint Intensive risk-adjusted follow-up with the CEA, TPA, CA19.9, and CA72.4 tumor marker panel and abdominal ultrasonography to diagnose operable colorectal cancer recurrences: effect on survival
    Andrea Nicolini
    Department of Internal Medicine, University of Pisa, Italy
    Arch Surg 145:1177-83. 2010
    ..Intensive risk-adjusted follow-up leads to improved resectability of tumor recurrences and better overall survival among patients who have undergone surgery for colorectal cancer...
  84. doi request reprint Clinicopathologic and molecular disease prognostication for papillary thyroid cancer
    Paolo Miccoli
    Department of Surgery, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Expert Rev Anticancer Ther 9:1261-75. 2009
    ..This article reviews the parameters used most commonly to differentiate low-risk PTCs from their more aggressive variants and describes some of the newest molecular therapies for this latter group of tumors...
  85. ncbi request reprint Carotid integrated backscatter analysis in patients with subclinical hypothyroidism
    Ferdinando Franzoni
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, 56126 Pisa, Italy
    Clin Endocrinol (Oxf) 68:278-83. 2008
    ....
  86. ncbi request reprint DNA damage evaluated by alkaline single cell gel electrophoresis (SCGE) in children of Chernobyl, 10 years after the disaster
    G Frenzilli
    Dipartimento di Scienze dell'Uomo e dell'Ambiente, , Via S. Giuseppe 22, 56100, Pisa, Italy
    Mutat Res 491:139-49. 2001
    ..04). The higher levels of genomic damage in children evaluated 10 years after the Chernobyl disaster could be related to the increased incidence of individuals with CF...
  87. ncbi request reprint HCV-related autoimmune and neoplastic disorders: the HCV syndrome
    C Ferri
    Chair and Rheumatology Unit, Department of Internal Medicine, University of Modena e Reggio Emilia, Medical Sehool, Modena, Italy
    Dig Liver Dis 39:S13-21. 2007
    ....
  88. ncbi request reprint HCV infection: pathogenesis, clinical manifestations and therapy
    A Antonelli
    University of Pisa School of Medicine, Pisa, Italy
    Clin Exp Rheumatol 26:S39-47. 2008
    ..In severe cases, rituximab is an apparently safe and effective alternative to conventional immunosuppression and, specifically, it controls B-cell proliferation...
  89. ncbi request reprint New trends in the treatment of undifferentiated carcinomas of the thyroid
    Paolo Miccoli
    Department of Surgery, University of Pisa, Pisa, Italy
    Langenbecks Arch Surg 392:397-404. 2007
    ..ATC is not only the most lethal disease in the field of endocrine surgery but also one of the most aggressive tumours characterized by an almost invariable fatal outcome, which only very rarely exceeds a 1-year course...
  90. doi request reprint Changes in heart rate variability and QT dispersion in patients with overt hypothyroidism
    Fabio Galetta
    Department of Internal Medicine, School of Medicine, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy
    Eur J Endocrinol 158:85-90. 2008
    ..The aim of the present study was to evaluate the effect of clinical hypothyroidism on cardiovascular autonomic function and ventricular repolarization...
  91. ncbi request reprint Mixed cryoglobulinemia: demographic, clinical, and serologic features and survival in 231 patients
    Clodoveo Ferri
    Department of Internal Medicine, University of Pisa Medical School, Pisa, Italy
    Semin Arthritis Rheum 33:355-74. 2004
    ..MC is characterized by multiple organ involvement, mainly skin, liver, renal, peripheral nerves, and less frequently by widespread vasculitis and cancer...
  92. doi request reprint In vitro and in vivo study on the antioxidant activity of dexrazoxane
    Fabio Galetta
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56126 Pisa, Italy
    Biomed Pharmacother 64:259-63. 2010
    ..Aim of the present study was to assess the in vitro and in vivo antioxidant effects of dexrazoxane...
  93. ncbi request reprint Prolonged in vitro exposure to autoantibodies against CD38 impairs the function and survival of human pancreatic islets
    Piero Marchetti
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Diabetes 51:S474-7. 2002
    ..9 +/- 0.4, P < 0.01). We conclude that prolonged exposure of human islets to sera positive for the presence of CD38Abs with [Ca(2+)](i)-mobilizing activity impairs beta-cell function and viability in cultured human pancreatic islets...
  94. ncbi request reprint Insulin: new roles for an ancient hormone
    E Ferrannini
    Metabolism Unit of the C N R Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Eur J Clin Invest 29:842-52. 1999
    ..Description and understanding of these new roles, their interactions, the interplay between insulin resistance and hyperinsulinaemia, and their implications for cardiovascular disease have only begun...
  95. ncbi request reprint Analysis of chromosome damage in circulating lymphocytes of radiological workers affected by thyroid nodules
    Roberto Scarpato
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via San Giuseppe 22, 56100, Pisa, Italy
    Mutat Res 606:21-6. 2006
    ..The existence of a possible association between chromosome aberrations and development of thyroid nodularity will be discussed...
  96. ncbi request reprint Durable and complete remission of a metastatic bladder sarcomatoid carcinoma with chemotherapic and surgical treatments
    Alessandro Antonelli
    Department of Urology, University of Brescia, Brescia, Italy
    Arch Ital Urol Androl 78:67-70. 2006
    ..Due to the rarity of the disease and the consequent unfeasibility of randomized studies, in our opinion these results, even if obtained in a single case, suggest a viable therapeutic option...
  97. ncbi request reprint Surgical treatment of adrenal metastasis from renal cell carcinoma: a single-centre experience of 45 patients
    Alessandro Antonelli
    Department of Urology, University of Brescia, Brescia, Italy
    BJU Int 97:505-8. 2006
    ..To report, in a retrospective study, the diagnostic problems and oncological results of surgery in patients with either synchronous or metachronous adrenal metastasis, which are uncommon in renal cancer, at 2-10% of patients...
  98. ncbi request reprint Induction of chromatid-type aberrations in peripheral lymphocytes of hospital workers exposed to very low doses of radiation
    Michela Ballardin
    Dipartimento di Biologia, University of Pisa, Via San Giuseppe 22, Pisa 56100, Italy
    Mutat Res 626:61-8. 2007
    ..Moreover, we did not detect any significant difference due to radiation exposure when CR rates were considered separately for each of the three chromosomes in the probe cocktail...
  99. ncbi request reprint Surgical treatment of metastases from renal cell carcinoma
    Alessandro Antonelli
    Department of Urology, University of Brescia, Brescia, Italy
    Arch Ital Urol Androl 77:125-8. 2005
    ....
  100. ncbi request reprint Clinical policies on the management of chronic kidney disease patients in Italy
    Francesco Locatelli
    Department of Nephrology, Ospedale A Manzoni, Lecco 23900, Italy
    Nephrol Dial Transplant 23:621-6. 2008
    ..The Italian Society of Nephrology (SIN) decided to undertake a multicentre study to obtain a clear picture of clinical policies on chronic kidney disease (CKD) in Italy...
  101. ncbi request reprint The follow-up management of non-metastatic renal cell carcinoma: definition of a surveillance protocol
    Alessandro Antonelli
    Department of Urology, University of Brescia, Brescia, Italy
    BJU Int 99:296-300. 2007
    ..To define a follow-up protocol based on the University of California Los Angeles Integrated Staging System (UISS) for patients undergoing surgery for N0M0 renal cell carcinoma (RCC)...