Research Topics
Genomes and Genes | Francesco AnnunziatoSummaryAffiliation: University of Florence Country: Italy Publications
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Publications
Heterogeneity of human effector CD4+ T cellsFrancesco Annunziato
Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel Therapies DENOthe, Department of Internal Medicine, University of Florence, Viale Morgagni 85, Florence 50134, Italy
Arthritis Res Ther 11:257. 2009..Despite the heterogeneity of CD4+ effector Th cells being higher than previously thought and some of their subsets exhibiting high plasticity, the Th1/Th2 paradigm still maintains a strong validity...
Distinctive features of classic and nonclassic (Th17 derived) human Th1 cellsLaura Maggi
Department of Internal Medicine and DENOTHE Center, University of Florence, Firenze, Italy
Eur J Immunol 42:3180-8. 2012....- Defining the human T helper 17 cell phenotypeFrancesco Annunziato
Department of Internal Medicine and DENOTHE Center, University of Florence, 50134 Firenze, Italy
Trends Immunol 33:505-12. 2012.... - Human and murine Th17Francesco Annunziato
Center of Excellence for Research, Transfer, and High Education DENOthe, University of Florence, Florence, Italy
Curr Opin HIV AIDS 5:114-9. 2010..The purpose of this review is to summarize the most recent discoveries in the field of phenotypic and functional characterization of human and murine Th17 cells... 
Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytesLorenzo Cosmi
Dipartimento di Medicina Interna, Viale Morgagni 85, Firenze 50134, Italy
Blood 102:4107-14. 2003..These results demonstrate the existence of a subset of human CD8+CD25+ thymocytes sharing phenotype, functional features, and mechanism of action with CD4+CD25+ T regulatory cells...- Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursorLorenzo Cosmi
Department of Internal Medicine and DENOTHE Center, University of Florence, Florence 50134, Italy
J Exp Med 205:1903-16. 2008..These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor... - TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cellsVeronica Santarlasci
Centre of Excellence DENOthe, University of Florence, Florence, Italy
Eur J Immunol 39:207-15. 2009..These data suggest that TGF-beta is not critical for the differentiation of human Th17 cells, but indirectly favors their expansion because Th17 cells are poorly susceptible to its suppressive effects... - Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interactionFrancesco Liotta
Excellence Center for Research, Transfer, and High Education, De Novo Therapy, University of Florence, Florence, Italy
J Allergy Clin Immunol 121:1000-5.e8. 2008..The mechanisms by which human dendritic cells (DCs) activate a TH1-polarizing or TH2-polarizing program are still partially unclear... - CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine productionPaola Romagnani
Center for Research, Transfer, and High Education DENOthe, University of Florence, Italy
J Allergy Clin Immunol 116:1372-9. 2005..This might represent an internal regulatory pathway of TH cell responses and might contribute to the modulation of chronic inflammatory reactions, including allergy... - Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signalingFrancesco Liotta
Excellence Center of the University of Florence De Novo Therapy, Florence, Italy
Stem Cells 26:279-89. 2008.... - Phenotypic and functional features of human Th17 cellsFrancesco Annunziato
Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence 50134, Italy
J Exp Med 204:1849-61. 2007.... - Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokinesLorenzo Cosmi
Department of Internal Medicine, University of Florence, Florence, Italy
Blood 103:3117-21. 2004.... - CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORCLaura Maggi
Centre of Excellence DENOthe, University of Florence, Italy
Eur J Immunol 40:2174-81. 2010..Taken together, these data allow to conclude that T-cell subsets able to produce IL-17, as well as precursors of IL-17-producing T cells, exhibit surface expression of CD161, and that this feature is at least in part RORC2-dependent... - Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4Lorenzo Cosmi
Centre of Excellence DENOthe, University of Florence, Florence, Italy
J Allergy Clin Immunol 125:222-30.e1-4. 2010..IL-17A has been suggested to play a pathogenic role in bronchial asthma and other allergic disorders... - Demonstration of circulating allergen-specific CD4+CD25highFoxp3+ T-regulatory cells in both nonatopic and atopic individualsLaura Maggi
Excellence Center for Research, Transfer, and High Education DENOthe, University of Florence, Italy
J Allergy Clin Immunol 120:429-36. 2007..CD4(+)CD25(+)Foxp3(+) T-regulatory (Treg) cells play a fundamental role in the control of autoimmunity. Whether human CD4(+)CD25(+)Foxp3(+) Treg cells that recognize foreign antigens also exist is less clear... - PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretionLaura Lasagni
Excellence Center for Research, Transfer and High Education De Novo Therapies, University of Florence, Florence, Italy
Blood 109:4127-34. 2007..These results demonstrate that CXCL4 and CXCL4L1 exhibit a distinct subcellular localization and are secreted in a differentially regulated manner, suggesting distinct roles in inflammatory or homeostatic processes... - The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammationFrancesco Annunziato
Center of Excellence for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, University of Florence, Florence, Italy
Int Immunol 20:1361-8. 2008.... - Regenerative potential of embryonic renal multipotent progenitors in acute renal failureElena Lazzeri
Excellence Center for Research, Transfer and High Education for the Development of DE NOVO THERAPIES, University of Florence, Florence, Italy
J Am Soc Nephrol 18:3128-38. 2007..The ability of these cells to repair renal damage, together with their apparent lack of tumorigenicity, suggests their potential in the treatment of renal failure... - Molecular mechanisms underlying the pro-inflammatory synergistic effect of tumor necrosis factor alpha and interferon gamma in human microvascular endotheliumAdriana Lombardi
Department of Clinical Physiopathology, DENOthe Center of Excellence for Research, Transfer and High Education, University of Florence, Viale Pieraccini 6, I 50139 Florence, Italy
Eur J Cell Biol 88:731-42. 2009..A further mechanism of synergism involving the reciprocal upregulation of TNFalpha-RII and of IFNgamma-R, in response to IFNgamma and TNFalpha, respectively, was revealed by flow cytometry and quantitative real time RT-PCR analysis... - Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7Alessandra Vultaggio
Center for Research, Transfer and High Education DENOthe, Department of Internal Medicine, University of Florence, Florence, Italy
J Immunol 182:880-9. 2009.... - CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitorsPaola Romagnani
Center for Research, Transfer and High Education DENOthe, University of Florence, Italy
Circ Res 97:314-22. 2005.... - Redirection of allergen-specific TH2 responses by a modified adenine through Toll-like receptor 7 interaction and IL-12/IFN releaseLucia Filì
DENOthe Center for Research, Transfer and High Education, University of Florence, Via Morgagni 85, 50134 Florence, Italy
J Allergy Clin Immunol 118:511-7. 2006.... - Human Th17 cells: are they different from murine Th17 cells?Francesco Annunziato
Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy
Eur J Immunol 39:637-40. 2009..However, although murine and human Th1 and Th2 cells exhibit strong similarities, human and murine Th17 cells seem to differ in several aspects... - Detection by flow cytometry of ESAT-6- and PPD-specific circulating CD4+ T lymphocytes as a diagnostic tool for tuberculosisLorenzo Cosmi
Center for High Research DENOthe, University of Florence, Florence, Italy
Int Arch Allergy Immunol 143:1-9. 2007.... - Functional features of human CD25+ regulatory thymocytesFrancesco Liotta
Center for Research, Transfer, High Education MCIDNENT, University of Florence, Italy
Microbes Infect 7:1017-22. 2005..This review discusses the phenotype and the functional features of the human naturally occurring CD25+ regulatory thymocytes... - Rarity of human T helper 17 cells is due to retinoic acid orphan receptor-dependent mechanisms that limit their expansionVeronica Santarlasci
Department of Internal Medicine and DENOTHE Center, University of Florence, 50134 Firenze, Italy
Immunity 36:201-14. 2012..Our findings suggest that the rarity of human Th17 cells in inflamed tissues results from RORC-dependent mechanisms limiting their expansion... - Properties and origin of human Th17 cellsSergio Romagnani
Department of Internal Medicine and Excellence Center DENOTHE, University of Florence, Firenze 50134, Italy
Mol Immunol 47:3-7. 2009..By contrast, TGF-beta does not play a direct role in human Th17 differentiation, but can only favour their expansion by inhibiting T-bet expression and the development of Th1 cells... - Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-BIlaria Petrai
Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, I 50134 Florence, Italy
Int J Biochem Cell Biol 40:1764-74. 2008..In conclusion, the p38(MAPK) pathway is a downstream effector of CXCR3-B implicated in the angiostatic action of this chemokine receptor... - Immunosuppression in cardiac graft rejection: a human in vitro model to study the potential use of new immunomodulatory drugsClara Crescioli
Center for Research Transfer and High Education DENOthe, University of Florence, Florence, Italy
Exp Cell Res 314:1337-50. 2008.... - Thymic regulatory T cellsEnrico Maggi
Center of Research, Transfer, High Education MCIDNENT, University of Florence, Firenze, Italy
Autoimmun Rev 4:579-86. 2005..The result that Th1 cells are highly susceptible to the suppressive activity of Treg thymocytes is consistent with the important role of these cells in protecting against the Th1-mediated immune response to autoantigens... - Frequency of regulatory T cells in peripheral blood and in tumour-infiltrating lymphocytes correlates with poor prognosis in renal cell carcinomaFrancesco Liotta
Excellence Center for Research, Transfer, and High Education DENOthe, Department of Urology, University of Florence, Florence, Italy
BJU Int 107:1500-6. 2011..To verify in vitro the inhibitory activity of tumour isolated Tregs on the effector T cells and, finally, to assess the prognostic role of Treg frequency determination... - The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cellsFrancesca Brugnolo
Department of Internal Medicine, Immunoallergology and Respiratory Disease Unit, University of Florence, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy
J Allergy Clin Immunol 111:380-8. 2003..CONCLUSIONS: These results suggest that R-848, and probably other imidazoquinolines, might be used as adjuvants in view of novel allergen-specific immunotherapeutic regimens for the treatment of allergic disorders... - CXC chemokines: the regulatory link between inflammation and angiogenesisPaola Romagnani
Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Trends Immunol 25:201-9. 2004 - Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritisLorenzo Cosmi
University of Florence and Excellence Centre for Research, Transfer and Higher Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, Florence, Italy
Arthritis Rheum 63:2504-15. 2011..To investigate the phenotype and function of CD4+ T cells in synovial fluid (SF) from the affected joints of children with oligoarticular-onset juvenile idiopathic arthritis (JIA), and to establish a possible link with disease activity... - Characterization of human adult stem-cell populations isolated from visceral and subcutaneous adipose tissueSilvana Baglioni
Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
FASEB J 23:3494-505. 2009..However, the visceral rather than the subcutaneous ASC could represent a more appropriate in vitro cell model for investigating the molecular mechanisms implicated in the pathophysiology of metabolic disorders such as obesity... - CD4+CD161+ T Lymphocytes Infiltrate Crohn's Disease-Associated Perianal Fistulas and Are Reduced by Anti-TNF-α Local TherapyLaura Maggi
Center for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
Int Arch Allergy Immunol 161:81-6. 2013.... - MARCKS actin-binding capacity mediates actin filament assembly during mitosis in human hepatic stellate cellsKrista Rombouts
Department of Internal Medicine, University of Florence, Italy
Am J Physiol Cell Physiol 303:C357-67. 2012..These findings implicate that MARCKS, an important PKC substrate, is essential for proper cytokinesis and that MARCKS and its partner actin are key mitotic regulators during cell cycle in hHSC... - Do studies in humans better depict Th17 cells?Francesco Annunziato
Department of Internal Medicine, Center of Excellence for Research, Transfer, and High Education De Novo Therapy DENOTHE, University of Florence, Florence, Italy
Blood 114:2213-9. 2009..Thus, we believe that studies in humans have better depicted human Th17 cells than studies in mice... - Type 17 T helper cells-origins, features and possible roles in rheumatic diseaseFrancesco Annunziato
Department of Internal Medicine, University of Florence, Firenze 50134, Italy
Nat Rev Rheumatol 5:325-31. 2009.... - Mouse T helper 17 phenotype: not so different than in man after allFrancesco Annunziato
Department of Internal Medicine and DENOTHE Center, University of Florence, Italy
Cytokine 56:112-5. 2011.... - Hypergravity speeds up the development of T-lymphocyte motilityMassimo Galimberti
LENS European Laboratory for Non Linear Spectroscopy, University of Florence, Sesto Fiorentino, FI, Italy
Eur Biophys J 35:393-400. 2006..We found that T cells, activated and then cultured in hypergravity, become motile earlier than cells cultured at normal gravity. These results suggest that hypergravity stimulates T cell migration... - Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneysCostanza Sagrinati
Interdepartmental Laboratory of Cellular and Molecular Nephrology, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy
J Am Soc Nephrol 17:2443-56. 2006.... - The transient nature of the Th17 phenotypeFrancesco Annunziato
Department of Internal Medicine, University of Florence, Florence, Italy
Eur J Immunol 40:3312-6. 2010..Our Commentary discusses this interesting point in light of previous data suggesting the same concept... - Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesisGabriella Fibbi
University of Florence, Florence, Italy
Arthritis Rheum 50:3275-85. 2004..CONCLUSION: Overproduction of MMP-12 by SSc MVECs accounts for the cleavage of uPAR and the impairment of angiogenesis in vitro and may contribute to reduced angiogenesis in SSc patients... - Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytesFrancesco Annunziato
Department of Internal Medicine, University Florence, Italy
J Exp Med 196:379-87. 2002.... - Multiorgan infiltration by CD8+ T cells and 1p;16p translocation in a patient with hypogammaglobulinemia and a reduced number of B cellsAlessandra Vultaggio
Immunoallergology Unit, Department of Biomedicine, AOU Careggi, Florence, Italy
Int Arch Allergy Immunol 158:206-10. 2012..This suggests that a chromosomal abnormality plays a role in the clinical features of this phenotypic variant of CVID... - The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis CAndrea Bonacchi
Dipartimento di Medicina Interna, University of Florence, Florence, Italy
Gastroenterology 125:1060-76. 2003..We investigated the expression of CCL21 and CCR7 in chronic hepatitis C. The effects of CCL21 on hepatic stellate cells (HSCs) were also studied... - An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4Laura Lasagni
Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
J Exp Med 197:1537-49. 2003.... - Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malariaMaria G Torcia
Department of Clinical Physiopathology, University of Firenze, Viale Pieraccini 6, 50139 Firenze, Italy
Proc Natl Acad Sci U S A 105:646-51. 2008..The results suggest that the higher resistance to malaria of the Fulani could derive from a functional deficit of T regulatory cells... - Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cellsAntonio Mazzocca
Dipartimento di Medicina Interna, Centro di Ricerca, Trasferimento e Alta Formazione MCIDNENT Università di Firenze, I 50134 Firenze, Italy
J Biol Chem 280:11329-39. 2005..Increased degradation of the normal hepatic extracellular matrix in areas where HCV is concentrated may favor inflammatory infiltration and further parenchymal damage... - Increased risk of lymphoid neoplasms in patients with Philadelphia chromosome-negative myeloproliferative neoplasmsAlessandro M Vannucchi
Unita Funzionale di Ematologia, Dipartimento di Area Critica, Universita degli Studi di Firenze, Florence, Italy
Cancer Epidemiol Biomarkers Prev 18:2068-73. 2009..We conclude that the risk of developing LPN is significantly increased in MPN patients compared with the general population... - IP-10 and Mig production by glomerular cells in human proliferative glomerulonephritis and regulation by nitric oxidePaola Romagnani
Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy
J Am Soc Nephrol 13:53-64. 2002..These data also indicate that the production of IP-10 and Mig by human mesangial cells can be downregulated by NO donors through cGMP-independent inhibition of NF-kappaB activation... - Up-regulated expression of fractalkine and its receptor CX3CR1 during liver injury in humansEva Efsen
Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, I 50134 Florence, Italy
J Hepatol 37:39-47. 2002..Little is known about the role of fractalkine (CX3CL1) in the liver. The aim of this study was to investigate the expression patterns of fractalkine and its receptor CX3CR1 in normal human liver and in conditions of injury...