Francesco Annunziato

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. pmc Heterogeneity of human effector CD4+ T cells
    Francesco Annunziato
    Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel Therapies DENOthe, Department of Internal Medicine, University of Florence, Viale Morgagni 85, Florence 50134, Italy
    Arthritis Res Ther 11:257. 2009
  2. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
  3. doi request reprint Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells
    Laura Maggi
    Department of Internal Medicine and DENOTHE Center, University of Florence, Firenze, Italy
    Eur J Immunol 42:3180-8. 2012
  4. doi request reprint Defining the human T helper 17 cell phenotype
    Francesco Annunziato
    Department of Internal Medicine and DENOTHE Center, University of Florence, 50134 Firenze, Italy
    Trends Immunol 33:505-12. 2012
  5. doi request reprint Human and murine Th17
    Francesco Annunziato
    Center of Excellence for Research, Transfer, and High Education DENOthe, University of Florence, Florence, Italy
    Curr Opin HIV AIDS 5:114-9. 2010
  6. ncbi request reprint Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes
    Lorenzo Cosmi
    Dipartimento di Medicina Interna, Viale Morgagni 85, Firenze 50134, Italy
    Blood 102:4107-14. 2003
  7. pmc Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
    Lorenzo Cosmi
    Department of Internal Medicine and DENOTHE Center, University of Florence, Florence 50134, Italy
    J Exp Med 205:1903-16. 2008
  8. doi request reprint TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells
    Veronica Santarlasci
    Centre of Excellence DENOthe, University of Florence, Florence, Italy
    Eur J Immunol 39:207-15. 2009
  9. doi request reprint Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction
    Francesco Liotta
    Excellence Center for Research, Transfer, and High Education, De Novo Therapy, University of Florence, Florence, Italy
    J Allergy Clin Immunol 121:1000-5.e8. 2008
  10. ncbi request reprint CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production
    Paola Romagnani
    Center for Research, Transfer, and High Education DENOthe, University of Florence, Italy
    J Allergy Clin Immunol 116:1372-9. 2005

Collaborators

Detail Information

Publications55

  1. pmc Heterogeneity of human effector CD4+ T cells
    Francesco Annunziato
    Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel Therapies DENOthe, Department of Internal Medicine, University of Florence, Viale Morgagni 85, Florence 50134, Italy
    Arthritis Res Ther 11:257. 2009
    ..Despite the heterogeneity of CD4+ effector Th cells being higher than previously thought and some of their subsets exhibiting high plasticity, the Th1/Th2 paradigm still maintains a strong validity...
  2. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
    ..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...
  3. doi request reprint Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells
    Laura Maggi
    Department of Internal Medicine and DENOTHE Center, University of Florence, Firenze, Italy
    Eur J Immunol 42:3180-8. 2012
    ....
  4. doi request reprint Defining the human T helper 17 cell phenotype
    Francesco Annunziato
    Department of Internal Medicine and DENOTHE Center, University of Florence, 50134 Firenze, Italy
    Trends Immunol 33:505-12. 2012
    ....
  5. doi request reprint Human and murine Th17
    Francesco Annunziato
    Center of Excellence for Research, Transfer, and High Education DENOthe, University of Florence, Florence, Italy
    Curr Opin HIV AIDS 5:114-9. 2010
    ..The purpose of this review is to summarize the most recent discoveries in the field of phenotypic and functional characterization of human and murine Th17 cells...
  6. ncbi request reprint Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes
    Lorenzo Cosmi
    Dipartimento di Medicina Interna, Viale Morgagni 85, Firenze 50134, Italy
    Blood 102:4107-14. 2003
    ..These results demonstrate the existence of a subset of human CD8+CD25+ thymocytes sharing phenotype, functional features, and mechanism of action with CD4+CD25+ T regulatory cells...
  7. pmc Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
    Lorenzo Cosmi
    Department of Internal Medicine and DENOTHE Center, University of Florence, Florence 50134, Italy
    J Exp Med 205:1903-16. 2008
    ..These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor...
  8. doi request reprint TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells
    Veronica Santarlasci
    Centre of Excellence DENOthe, University of Florence, Florence, Italy
    Eur J Immunol 39:207-15. 2009
    ..These data suggest that TGF-beta is not critical for the differentiation of human Th17 cells, but indirectly favors their expansion because Th17 cells are poorly susceptible to its suppressive effects...
  9. doi request reprint Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction
    Francesco Liotta
    Excellence Center for Research, Transfer, and High Education, De Novo Therapy, University of Florence, Florence, Italy
    J Allergy Clin Immunol 121:1000-5.e8. 2008
    ..The mechanisms by which human dendritic cells (DCs) activate a TH1-polarizing or TH2-polarizing program are still partially unclear...
  10. ncbi request reprint CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production
    Paola Romagnani
    Center for Research, Transfer, and High Education DENOthe, University of Florence, Italy
    J Allergy Clin Immunol 116:1372-9. 2005
    ..Two variants of the CXCR3 receptor exist, one (CXCR3-A) reactive with CXCL9, CXCL10, and CXCL11 and the other (CXCR3-B) also reactive with CXCL4. Both variants are contemporarily expressed by human T cells...
  11. ncbi request reprint Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling
    Francesco Liotta
    Excellence Center of the University of Florence De Novo Therapy, Florence, Italy
    Stem Cells 26:279-89. 2008
    ....
  12. pmc Phenotypic and functional features of human Th17 cells
    Francesco Annunziato
    Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence 50134, Italy
    J Exp Med 204:1849-61. 2007
    ....
  13. doi request reprint Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4
    Lorenzo Cosmi
    Centre of Excellence DENOthe, University of Florence, Florence, Italy
    J Allergy Clin Immunol 125:222-30.e1-4. 2010
    ..IL-17A has been suggested to play a pathogenic role in bronchial asthma and other allergic disorders...
  14. ncbi request reprint Demonstration of circulating allergen-specific CD4+CD25highFoxp3+ T-regulatory cells in both nonatopic and atopic individuals
    Laura Maggi
    Excellence Center for Research, Transfer, and High Education DENOthe, University of Florence, Italy
    J Allergy Clin Immunol 120:429-36. 2007
    ..CD4(+)CD25(+)Foxp3(+) T-regulatory (Treg) cells play a fundamental role in the control of autoimmunity. Whether human CD4(+)CD25(+)Foxp3(+) Treg cells that recognize foreign antigens also exist is less clear...
  15. doi request reprint CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC
    Laura Maggi
    Centre of Excellence DENOthe, University of Florence, Italy
    Eur J Immunol 40:2174-81. 2010
    ..Taken together, these data allow to conclude that T-cell subsets able to produce IL-17, as well as precursors of IL-17-producing T cells, exhibit surface expression of CD161, and that this feature is at least in part RORC2-dependent...
  16. ncbi request reprint Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines
    Lorenzo Cosmi
    Department of Internal Medicine, University of Florence, Florence, Italy
    Blood 103:3117-21. 2004
    ....
  17. ncbi request reprint PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion
    Laura Lasagni
    Excellence Center for Research, Transfer and High Education De Novo Therapies, University of Florence, Florence, Italy
    Blood 109:4127-34. 2007
    ..These results demonstrate that CXCL4 and CXCL4L1 exhibit a distinct subcellular localization and are secreted in a differentially regulated manner, suggesting distinct roles in inflammatory or homeostatic processes...
  18. doi request reprint The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation
    Francesco Annunziato
    Center of Excellence for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, University of Florence, Florence, Italy
    Int Immunol 20:1361-8. 2008
    ....
  19. ncbi request reprint Regenerative potential of embryonic renal multipotent progenitors in acute renal failure
    Elena Lazzeri
    Excellence Center for Research, Transfer and High Education for the Development of DE NOVO THERAPIES, University of Florence, Florence, Italy
    J Am Soc Nephrol 18:3128-38. 2007
    ..The ability of these cells to repair renal damage, together with their apparent lack of tumorigenicity, suggests their potential in the treatment of renal failure...
  20. doi request reprint Molecular mechanisms underlying the pro-inflammatory synergistic effect of tumor necrosis factor alpha and interferon gamma in human microvascular endothelium
    Adriana Lombardi
    Department of Clinical Physiopathology, DENOthe Center of Excellence for Research, Transfer and High Education, University of Florence, Viale Pieraccini 6, I 50139 Florence, Italy
    Eur J Cell Biol 88:731-42. 2009
    ..A further mechanism of synergism involving the reciprocal upregulation of TNFalpha-RII and of IFNgamma-R, in response to IFNgamma and TNFalpha, respectively, was revealed by flow cytometry and quantitative real time RT-PCR analysis...
  21. ncbi request reprint Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7
    Alessandra Vultaggio
    Center for Research, Transfer and High Education DENOthe, Department of Internal Medicine, University of Florence, Florence, Italy
    J Immunol 182:880-9. 2009
    ....
  22. ncbi request reprint CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitors
    Paola Romagnani
    Center for Research, Transfer and High Education DENOthe, University of Florence, Italy
    Circ Res 97:314-22. 2005
    ....
  23. ncbi request reprint Redirection of allergen-specific TH2 responses by a modified adenine through Toll-like receptor 7 interaction and IL-12/IFN release
    Lucia Filì
    DENOthe Center for Research, Transfer and High Education, University of Florence, Via Morgagni 85, 50134 Florence, Italy
    J Allergy Clin Immunol 118:511-7. 2006
    ....
  24. doi request reprint Human Th17 cells: are they different from murine Th17 cells?
    Francesco Annunziato
    Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy
    Eur J Immunol 39:637-40. 2009
    ..However, although murine and human Th1 and Th2 cells exhibit strong similarities, human and murine Th17 cells seem to differ in several aspects...
  25. ncbi request reprint Detection by flow cytometry of ESAT-6- and PPD-specific circulating CD4+ T lymphocytes as a diagnostic tool for tuberculosis
    Lorenzo Cosmi
    Center for High Research DENOthe, University of Florence, Florence, Italy
    Int Arch Allergy Immunol 143:1-9. 2007
    ....
  26. ncbi request reprint Functional features of human CD25+ regulatory thymocytes
    Francesco Liotta
    Center for Research, Transfer, High Education MCIDNENT, University of Florence, Italy
    Microbes Infect 7:1017-22. 2005
    ..This review discusses the phenotype and the functional features of the human naturally occurring CD25+ regulatory thymocytes...
  27. doi request reprint Rarity of human T helper 17 cells is due to retinoic acid orphan receptor-dependent mechanisms that limit their expansion
    Veronica Santarlasci
    Department of Internal Medicine and DENOTHE Center, University of Florence, 50134 Firenze, Italy
    Immunity 36:201-14. 2012
    ..Our findings suggest that the rarity of human Th17 cells in inflamed tissues results from RORC-dependent mechanisms limiting their expansion...
  28. doi request reprint Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B
    Ilaria Petrai
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, I 50134 Florence, Italy
    Int J Biochem Cell Biol 40:1764-74. 2008
    ..In conclusion, the p38(MAPK) pathway is a downstream effector of CXCR3-B implicated in the angiostatic action of this chemokine receptor...
  29. doi request reprint Properties and origin of human Th17 cells
    Sergio Romagnani
    Department of Internal Medicine and Excellence Center DENOTHE, University of Florence, Firenze 50134, Italy
    Mol Immunol 47:3-7. 2009
    ..By contrast, TGF-beta does not play a direct role in human Th17 differentiation, but can only favour their expansion by inhibiting T-bet expression and the development of Th1 cells...
  30. doi request reprint CD4+CD161+ T lymphocytes infiltrate Crohn's disease-associated perianal fistulas and are reduced by anti-TNF-α local therapy
    Laura Maggi
    Center for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Int Arch Allergy Immunol 161:81-6. 2013
    ..In this work we assessed the presence and the functional features of CD161 T helper lymphocytes infiltrating CD-associated perianal fistulas, both before and after inoculation of anti-TNF-α mAbs along the fistula...
  31. doi request reprint Main features of human T helper 17 cells
    Francesco Annunziato
    Laboratory of Immunology, Allergology and Cellular Therapies, Department of Internal Medicine and DENOTHE Center, University of Florence, Italy
    Ann N Y Acad Sci 1284:66-70. 2013
    ..The possible role of Th17 cells in human tumors is still unclear and even controversial...
  32. doi request reprint Immunosuppression in cardiac graft rejection: a human in vitro model to study the potential use of new immunomodulatory drugs
    Clara Crescioli
    Center for Research Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Exp Cell Res 314:1337-50. 2008
    ....
  33. doi request reprint Frequency of regulatory T cells in peripheral blood and in tumour-infiltrating lymphocytes correlates with poor prognosis in renal cell carcinoma
    Francesco Liotta
    Excellence Center for Research, Transfer, and High Education DENOthe, Department of Urology, University of Florence, Florence, Italy
    BJU Int 107:1500-6. 2011
    ..To verify in vitro the inhibitory activity of tumour isolated Tregs on the effector T cells and, finally, to assess the prognostic role of Treg frequency determination...
  34. ncbi request reprint Thymic regulatory T cells
    Enrico Maggi
    Center of Research, Transfer, High Education MCIDNENT, University of Florence, Firenze, Italy
    Autoimmun Rev 4:579-86. 2005
    ..The result that Th1 cells are highly susceptible to the suppressive activity of Treg thymocytes is consistent with the important role of these cells in protecting against the Th1-mediated immune response to autoantigens...
  35. ncbi request reprint The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cells
    Francesca Brugnolo
    Department of Internal Medicine, Immunoallergology and Respiratory Disease Unit, University of Florence, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy
    J Allergy Clin Immunol 111:380-8. 2003
    ..In experimental models, imidazoquinolines exhibit several immunomodulatory activities via Toll-like receptor signaling on cells of the innate immunity...
  36. doi request reprint Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis
    Lorenzo Cosmi
    University of Florence and Excellence Centre for Research, Transfer and Higher Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, Florence, Italy
    Arthritis Rheum 63:2504-15. 2011
    ..To investigate the phenotype and function of CD4+ T cells in synovial fluid (SF) from the affected joints of children with oligoarticular-onset juvenile idiopathic arthritis (JIA), and to establish a possible link with disease activity...
  37. ncbi request reprint CXC chemokines: the regulatory link between inflammation and angiogenesis
    Paola Romagnani
    Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Trends Immunol 25:201-9. 2004
  38. doi request reprint Characterization of human adult stem-cell populations isolated from visceral and subcutaneous adipose tissue
    Silvana Baglioni
    Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    FASEB J 23:3494-505. 2009
    ..However, the visceral rather than the subcutaneous ASC could represent a more appropriate in vitro cell model for investigating the molecular mechanisms implicated in the pathophysiology of metabolic disorders such as obesity...
  39. doi request reprint MARCKS actin-binding capacity mediates actin filament assembly during mitosis in human hepatic stellate cells
    Krista Rombouts
    Department of Internal Medicine, University of Florence, Italy
    Am J Physiol Cell Physiol 303:C357-67. 2012
    ..These findings implicate that MARCKS, an important PKC substrate, is essential for proper cytokinesis and that MARCKS and its partner actin are key mitotic regulators during cell cycle in hHSC...
  40. doi request reprint Type 17 T helper cells-origins, features and possible roles in rheumatic disease
    Francesco Annunziato
    Department of Internal Medicine, University of Florence, Firenze 50134, Italy
    Nat Rev Rheumatol 5:325-31. 2009
    ....
  41. doi request reprint Do studies in humans better depict Th17 cells?
    Francesco Annunziato
    Department of Internal Medicine, Center of Excellence for Research, Transfer, and High Education De Novo Therapy DENOTHE, University of Florence, Florence, Italy
    Blood 114:2213-9. 2009
    ..Thus, we believe that studies in humans have better depicted human Th17 cells than studies in mice...
  42. doi request reprint Mouse T helper 17 phenotype: not so different than in man after all
    Francesco Annunziato
    Department of Internal Medicine and DENOTHE Center, University of Florence, Italy
    Cytokine 56:112-5. 2011
    ....
  43. ncbi request reprint Hypergravity speeds up the development of T-lymphocyte motility
    Massimo Galimberti
    LENS European Laboratory for Non Linear Spectroscopy, University of Florence, Sesto Fiorentino, FI, Italy
    Eur Biophys J 35:393-400. 2006
    ..We found that T cells, activated and then cultured in hypergravity, become motile earlier than cells cultured at normal gravity. These results suggest that hypergravity stimulates T cell migration...
  44. ncbi request reprint Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys
    Costanza Sagrinati
    Interdepartmental Laboratory of Cellular and Molecular Nephrology, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy
    J Am Soc Nephrol 17:2443-56. 2006
    ....
  45. doi request reprint The transient nature of the Th17 phenotype
    Francesco Annunziato
    Department of Internal Medicine, University of Florence, Florence, Italy
    Eur J Immunol 40:3312-6. 2010
    ..Our Commentary discusses this interesting point in light of previous data suggesting the same concept...
  46. ncbi request reprint Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis
    Silvia D'Alessio
    University of Florence, Florence, Italy
    Arthritis Rheum 50:3275-85. 2004
    ....
  47. pmc Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes
    Francesco Annunziato
    Department of Internal Medicine, University Florence, Italy
    J Exp Med 196:379-87. 2002
    ....
  48. doi request reprint Multiorgan infiltration by CD8+ T cells and 1p;16p translocation in a patient with hypogammaglobulinemia and a reduced number of B cells
    Alessandra Vultaggio
    Immunoallergology Unit, Department of Biomedicine, AOU Careggi, Florence, Italy
    Int Arch Allergy Immunol 158:206-10. 2012
    ..This suggests that a chromosomal abnormality plays a role in the clinical features of this phenotypic variant of CVID...
  49. ncbi request reprint The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C
    Andrea Bonacchi
    Dipartimento di Medicina Interna, University of Florence, Florence, Italy
    Gastroenterology 125:1060-76. 2003
    ..We investigated the expression of CCL21 and CCR7 in chronic hepatitis C. The effects of CCL21 on hepatic stellate cells (HSCs) were also studied...
  50. pmc An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4
    Laura Lasagni
    Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Exp Med 197:1537-49. 2003
    ....
  51. ncbi request reprint Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cells
    Antonio Mazzocca
    Dipartimento di Medicina Interna, Centro di Ricerca, Trasferimento e Alta Formazione MCIDNENT Università di Firenze, I 50134 Firenze, Italy
    J Biol Chem 280:11329-39. 2005
    ..Increased degradation of the normal hepatic extracellular matrix in areas where HCV is concentrated may favor inflammatory infiltration and further parenchymal damage...
  52. pmc Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malaria
    Maria G Torcia
    Department of Clinical Physiopathology, University of Firenze, Viale Pieraccini 6, 50139 Firenze, Italy
    Proc Natl Acad Sci U S A 105:646-51. 2008
    ..The results suggest that the higher resistance to malaria of the Fulani could derive from a functional deficit of T regulatory cells...
  53. doi request reprint Increased risk of lymphoid neoplasms in patients with Philadelphia chromosome-negative myeloproliferative neoplasms
    Alessandro M Vannucchi
    Unita Funzionale di Ematologia, Dipartimento di Area Critica, Universita degli Studi di Firenze, Florence, Italy
    Cancer Epidemiol Biomarkers Prev 18:2068-73. 2009
    ..We conclude that the risk of developing LPN is significantly increased in MPN patients compared with the general population...
  54. ncbi request reprint IP-10 and Mig production by glomerular cells in human proliferative glomerulonephritis and regulation by nitric oxide
    Paola Romagnani
    Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy
    J Am Soc Nephrol 13:53-64. 2002
    ..These data also indicate that the production of IP-10 and Mig by human mesangial cells can be downregulated by NO donors through cGMP-independent inhibition of NF-kappaB activation...
  55. ncbi request reprint Up-regulated expression of fractalkine and its receptor CX3CR1 during liver injury in humans
    Eva Efsen
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, I 50134 Florence, Italy
    J Hepatol 37:39-47. 2002
    ..Little is known about the role of fractalkine (CX3CL1) in the liver. The aim of this study was to investigate the expression patterns of fractalkine and its receptor CX3CR1 in normal human liver and in conditions of injury...