Fabio Angeli

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi request reprint Modern treatment of patients at risk: still a HOPE for ACE inhibitors?
    Fabio Angeli
    Expert Opin Pharmacother 12:839-43. 2011
  2. doi request reprint Very early initiation of statin therapy and mortality in patients with acute coronary syndrome
    Fabio Angeli
    Section of Cardiology, Hospital Media Valle del Tevere, AUSL 2 Umbria, and Department of Internal Medicine, University of Perugia, Perugia Italy
    Acute Card Care 14:34-9. 2012
  3. doi request reprint Statins in acute coronary syndrome: very early initiation and benefits
    Fabio Angeli
    Section of Cardiology, Hospital Media Valle del Tevere, AUSL 2, Umbria, Perugia, Italy
    Ther Adv Cardiovasc Dis 6:163-74. 2012
  4. doi request reprint Fixed-dose combination therapy in hypertension: cons
    Fabio Angeli
    Section of Cardiology, Hospital Media Valle del Tevere, Umbria, Perugia, Italy
    High Blood Press Cardiovasc Prev 19:51-4. 2012
  5. doi request reprint Atrial fibrillation and mortality in patients with acute myocardial infarction: a systematic overview and meta-analysis
    Fabio Angeli
    Section of Cardiology, Hospital Media Valle del Tevere, AUSL 2, Umbria, Italy
    Curr Cardiol Rep 14:601-10. 2012
  6. doi request reprint Safety and efficacy of aliskiren in the treatment of hypertension: a systematic overview
    Fabio Angeli
    Hospital Media Valle del Tevere Pantalla, AUSL 2 Umbria, Department of Cardiology, Section of Cardiology, Perugia, Italy
    Expert Opin Drug Saf 11:659-70. 2012
  7. ncbi request reprint Safety and efficacy of aliskiren in the treatment of hypertension and associated clinical conditions
    Fabio Angeli
    Section of Cardiology, Hospital Media Valle del Tevere, AUSL 2 Umbria, Perugia, Italy
    Curr Drug Saf 7:76-85. 2012
  8. doi request reprint Beta-blockers and risk of all-cause mortality in non-cardiac surgery
    Fabio Angeli
    Department of Cardiology, Hospital Santa Maria della Misericordia, Perugia, Italy
    Ther Adv Cardiovasc Dis 4:109-18. 2010
  9. doi request reprint Neutrophil count for the identification of postmenopausal hypertensive women at increased cardiovascular risk
    Fabio Angeli
    Department of Cardiology and Clinical Research Unit Preventive Cardiology, Hospital S Maria della Misericordia, Perugia, and Department of Cardiovascular Pathophysiology, University of Perugia, Perugia and Department of Internal Medicine, University of Perugia, Perugia, Italy
    Obstet Gynecol 115:695-703. 2010
  10. ncbi request reprint [Ambulatory blood pressure monitoring in clinical practice]
    Fabio Angeli
    Struttura Complessa di Cardiologia, Ospedale S Maria della Misericordia, Universita degli Studi, Perugia
    G Ital Cardiol (Rome) 9:402-7. 2008

Detail Information

Publications84

  1. ncbi request reprint Modern treatment of patients at risk: still a HOPE for ACE inhibitors?
    Fabio Angeli
    Expert Opin Pharmacother 12:839-43. 2011
    ....
  2. doi request reprint Very early initiation of statin therapy and mortality in patients with acute coronary syndrome
    Fabio Angeli
    Section of Cardiology, Hospital Media Valle del Tevere, AUSL 2 Umbria, and Department of Internal Medicine, University of Perugia, Perugia Italy
    Acute Card Care 14:34-9. 2012
    ..Current guidelines for the treatment of patients with acute coronary syndrome (ACS) recommend the use of statins before hospital discharge. However, the prognostic impact of an early initiation of treatment is uncertain...
  3. doi request reprint Statins in acute coronary syndrome: very early initiation and benefits
    Fabio Angeli
    Section of Cardiology, Hospital Media Valle del Tevere, AUSL 2, Umbria, Perugia, Italy
    Ther Adv Cardiovasc Dis 6:163-74. 2012
    ..Given these recognized potential benefit, statins should conceivably modulate the pathophysiological processes involved in the very early phase of plaque rupture and coronary thrombosis...
  4. doi request reprint Fixed-dose combination therapy in hypertension: cons
    Fabio Angeli
    Section of Cardiology, Hospital Media Valle del Tevere, Umbria, Perugia, Italy
    High Blood Press Cardiovasc Prev 19:51-4. 2012
    ..Currently, none of the fixed-dose tablets available on the market have these characteristics and, consequently, are unable to be broken to allow sufficient flexibility...
  5. doi request reprint Atrial fibrillation and mortality in patients with acute myocardial infarction: a systematic overview and meta-analysis
    Fabio Angeli
    Section of Cardiology, Hospital Media Valle del Tevere, AUSL 2, Umbria, Italy
    Curr Cardiol Rep 14:601-10. 2012
    ..013) or AF uncertain (P = 0.003), and not dissimilar in patients with new AF uncertain and permanent AF (P = 0.706)...
  6. doi request reprint Safety and efficacy of aliskiren in the treatment of hypertension: a systematic overview
    Fabio Angeli
    Hospital Media Valle del Tevere Pantalla, AUSL 2 Umbria, Department of Cardiology, Section of Cardiology, Perugia, Italy
    Expert Opin Drug Saf 11:659-70. 2012
    ..Aliskiren's inhibitory effect on angiotensin I generation, through renin blockade, is highly specific and long-lasting (24 hours). This feature differentiates aliskiren from traditional antihypertensive drugs...
  7. ncbi request reprint Safety and efficacy of aliskiren in the treatment of hypertension and associated clinical conditions
    Fabio Angeli
    Section of Cardiology, Hospital Media Valle del Tevere, AUSL 2 Umbria, Perugia, Italy
    Curr Drug Saf 7:76-85. 2012
    ..This review summarizes the available data on its safety profile and its clinical development for treatment of arterial hypertension, diabetes and nephropathy...
  8. doi request reprint Beta-blockers and risk of all-cause mortality in non-cardiac surgery
    Fabio Angeli
    Department of Cardiology, Hospital Santa Maria della Misericordia, Perugia, Italy
    Ther Adv Cardiovasc Dis 4:109-18. 2010
    ..27, 95% CI 0.10-0.71, p = 0.016). These data suggest that perioperative beta-blockers confer a benefit which is mostly limited to patients undergoing high-risk surgery...
  9. doi request reprint Neutrophil count for the identification of postmenopausal hypertensive women at increased cardiovascular risk
    Fabio Angeli
    Department of Cardiology and Clinical Research Unit Preventive Cardiology, Hospital S Maria della Misericordia, Perugia, and Department of Cardiovascular Pathophysiology, University of Perugia, Perugia and Department of Internal Medicine, University of Perugia, Perugia, Italy
    Obstet Gynecol 115:695-703. 2010
    ..We tested the independent prognostic value of total white blood cell and neutrophil counts for cardiovascular events in hypertensive postmenopausal women...
  10. ncbi request reprint [Ambulatory blood pressure monitoring in clinical practice]
    Fabio Angeli
    Struttura Complessa di Cardiologia, Ospedale S Maria della Misericordia, Universita degli Studi, Perugia
    G Ital Cardiol (Rome) 9:402-7. 2008
    ..The superiority of ambulatory over clinic BP in predicting clinical outcome and the most appropriate way of interpreting results of ambulatory BP monitoring will be discussed in this review...
  11. ncbi request reprint Day-to-day variability of electrocardiographic diagnosis of left ventricular hypertrophy in hypertensive patients. Influence of electrode placement
    Fabio Angeli
    Clinical Research Unit Preventive Cardiology, Department of Cardiovascular Diseases, R Silvestrini Hospital, Perugia, Italy
    J Cardiovasc Med (Hagerstown) 7:812-6. 2006
    ....
  12. doi request reprint Neutrophil count and ambulatory pulse pressure as predictors of cardiovascular adverse events in postmenopausal women with hypertension
    Fabio Angeli
    Department of Cardiology, Hospital S Maria della Misericordia, Perugia, Italy
    Am J Hypertens 24:591-8. 2011
    ..We also tested PP as predictor of cardiovascular adverse events in this population...
  13. ncbi request reprint Validation of the A&D wrist-cuff UB-511 (UB-512) device for self-measurement of blood pressure
    Fabio Angeli
    Clinic Research Unit, Preventive Cardiology, Department of Cardiology, R Silvestrini Hospital, Perugia, Italy
    Blood Press Monit 11:349-54. 2006
    ..To determine the accuracy of the A&D UB-511 (UB-512) oscillometric wrist-cuff device for self-measurement of blood pressure, the only difference between the two devices being the size of storage memory...
  14. doi request reprint Electrocardiographic abnormalities of left ventricular repolarization: prognostic implications in hypertensive post-menopausal women
    Fabio Angeli
    Department of Cardiology and Clinical Research Unit, Preventive Cardiology, Hospital S Maria della Misericordia, 06100 Perugia, Italy
    Maturitas 67:159-65. 2010
    ..Although repolarization abnormalities on ECG are frequent in post-menopausal hypertensive women, their prognostic value in these women is uncertain...
  15. ncbi request reprint Good news for beta-blockers in perioperative medicine
    Fabio Angeli
    Expert Opin Drug Saf 10:491-8. 2011
    ..In particular, we examine the results of a recent meta-analysis that suggests that β-blockers may reduce mortality in patients under going high-risk non-cardiac surgery...
  16. ncbi request reprint New-onset hyperglycemia and acute coronary syndrome: a systematic overview and meta-analysis
    Fabio Angeli
    Department of Cardiology, Hospital Santa Maria della Misericordia, 06100 Perugia Italy
    Curr Diabetes Rev 6:102-10. 2010
    ..Patients without a history of diabetes often develop hyperglycemia during an acute coronary syndrome (ACS). New onset of hyperglycemia (NH) is associated with higher mortality both in the short and long-term...
  17. ncbi request reprint Association between periodontal disease and left ventricle mass in essential hypertension
    Fabio Angeli
    Dipartimento Malattie Cardiovascolari, Università degli Studi di Perugia and Ospedale R Silvestrini, Perugia, Italy
    Hypertension 41:488-92. 2003
    ..Periodontal evaluation might contribute to refine cardiovascular risk assessment in hypertensive subjects...
  18. ncbi request reprint Asymptomatic left ventricular systolic dysfunction in essential hypertension: prevalence, determinants, and prognostic value
    Paolo Verdecchia
    Department of Cardiovascular Disease, R Silvestrini Hospital, Perugia, Italy
    Hypertension 45:412-8. 2005
    ..62x100 person years) events did not differ (all P=NS) between subjects with and without ALVSD. ALVSD is a potent and early marker of evolution toward severe CHF requiring hospitalization in subjects with essential hypertension...
  19. doi request reprint Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial
    Paolo Verdecchia
    Division of Cardiology, Hospital S Maria della Misericordia, Perugia, Italy
    Lancet 374:525-33. 2009
    ..We tested the hypothesis that tight control compared with usual control of systolic blood pressure would be beneficial in such patients...
  20. pmc Comparative assessment of angiotensin receptor blockers in different clinical settings
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Unità di Ricerca Clinica Cardiologia Preventiva, Ospedale S Maria della Misericordia, Perugia, Italy
    Vasc Health Risk Manag 5:939-48. 2009
    ..The present review provides a comparative assessment of the different ARBs in their efficacy on major clinical endpoints along the different steps of the cardiovascular disease continuum...
  21. pmc Choice of ACE inhibitor combinations in hypertensive patients with type 2 diabetes: update after recent clinical trials
    Gianpaolo Reboldi
    1Department of internal Medicine University of Perugia, Perugia, Italy
    Vasc Health Risk Manag 5:411-27. 2009
    ..The present review will focus on different ACE inhibitor combinations in the treatment of patients with type 2 diabetes mellitus and hypertension, in the light of recent clinical trials, including GUARD and ACCOMPLISH...
  22. ncbi request reprint Adverse prognostic significance of new diabetes in treated hypertensive subjects
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Universita di Perugia, Ospedale R Silvestrini S Andrea delle Fratte 06122 Perugia, Italy
    Hypertension 43:963-9. 2004
    ..In treated hypertensive subjects, occurrence of new diabetes portends a risk for subsequent cardiovascular disease that is not dissimilar from that of previously known diabetes...
  23. doi request reprint The voltage of R wave in lead aVL improves risk stratification in hypertensive patients without ECG left ventricular hypertrophy
    Paolo Verdecchia
    Department of Cardiology, Clinical Research Unit Preventive Cardiology, Hospital S Maria della Misericordia, Cardiologia, PiazzaleG Menghini, Perugia 06132, Italy
    J Hypertens 27:1697-704. 2009
    ..We tested the hypothesis that the voltages of QRS on ECG improve risk stratification in hypertensive patients without left ventricular hypertrophy on ECG...
  24. ncbi request reprint Improved cardiovascular risk stratification by a simple ECG index in hypertension
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Universita di Perugia, Ospedale R Silvestrini, S Andrea delle Fratte, 06122 Perugia, Italy
    Am J Hypertens 16:646-52. 2003
    ..0 mV in women or 2.4 mV in men, or both...
  25. doi request reprint Blood pressure reduction and renin-angiotensin system inhibition for prevention of congestive heart failure: a meta-analysis
    Paolo Verdecchia
    Ospedale S Maria della Misericordia, Cardiologia, Perugia, Italy
    Eur Heart J 30:679-88. 2009
    ..It is unclear whether prevention of congestive heart failure (CHF) by drugs that inhibit the renin-angiotensin system (RAS) occurs over and beyond the reduction in blood pressure (BP) achieved by these drugs...
  26. doi request reprint Aliskiren versus ramipril in hypertension
    Paolo Verdecchia
    Department of Cardiology, Clinical Research Unit Preventive Cardiology, Hospital Santa Maria della Misericordia, 06156 Perugia, Italy
    Ther Adv Cardiovasc Dis 4:193-200. 2010
    ..These data provide further evidence that aliskiren monotherapy provides a sustained BP reduction over the 24 hours...
  27. pmc The renin angiotensin system in the development of cardiovascular disease: role of aliskiren in risk reduction
    Paolo Verdecchia
    Department of Cardiology, Clinical Research Unit Preventive Cardiology, Hospital Santa Maria della Misericordia, and Fondazione Umbra Cuore e Ipertensione AUCI Onlus, Perugia, Italy
    Vasc Health Risk Manag 4:971-81. 2008
    ..Hypertension is an approved indication for this drug, which is also promising for the treatment of heart failure. The efficacy of this drug in reducing major clinical events is being tested in large ongoing clinical trials...
  28. ncbi request reprint Regression of left ventricular hypertrophy and prevention of stroke in hypertensive subjects
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Hospital R Silvestrini, Perugia, Italy
    Am J Hypertens 19:493-9. 2006
    ..The relationship between serial LVH changes and risk of stroke has never been investigated in a mixed population of hypertensive subjects with and without LVH...
  29. ncbi request reprint Ambulatory blood pressure and cardiovascular outcome in relation to perceived sleep deprivation
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Unità di Ricerca Clinica Cardiologia Preventiva, Ospedale S Maria della Misericordia, Universita di Perugia, Perugia, Italy
    Hypertension 49:777-83. 2007
    ..In conclusion, nighttime BP rises and loses its prognostic significance in the hypertensive subjects who perceive a sleep deprivation by >or=2 hours during overnight monitoring...
  30. doi request reprint Exploring the optimal combination therapy in hypertensive patients with diabetes mellitus
    Gianpaolo Reboldi
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Expert Rev Cardiovasc Ther 7:1349-61. 2009
    ..The present review explores the potential for an 'optimal' combination therapy in patients with diabetes mellitus and hypertension, in view of recent experimental and clinical evidence...
  31. ncbi request reprint Regression of left ventricular hypertrophy and cardiovascular risk changes in hypertensive patients
    Paolo Verdecchia
    Department of Cardiovascular Diseases, R Silvestrini Hospital, Perugia, Italy
    Ital Heart J 5:505-10. 2004
    ..According to a recent meta-analysis, effective reversal of LVH is associated with a 59% lesser risk of subsequent adverse events as compared with the persistence or new development of LVH...
  32. doi request reprint Optimal therapy in hypertensive subjects with diabetes mellitus
    Gianpaolo Reboldi
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126, Perugia, Italy
    Curr Atheroscler Rep 13:176-85. 2011
    ....
  33. ncbi request reprint Prognostic value of lipoprotein fractions in essential hypertension
    Paolo Verdecchia
    Ospedale R Silvestrini, Dipartimento Malattie Cardiovascolari, Italy
    Blood Press 13:295-303. 2004
    ..To evaluate distribution and prognostic value of total cholesterol and lipoprotein fractions in essential hypertension...
  34. doi request reprint Is the definition of daytime and nighttime blood pressure prognostically relevant?
    Paolo Verdecchia
    Hospital S Maria della Misericordia, Clinical Research Unit Preventive Cardiology, University of Perugia, Piazzale G Menghini, Perugia, Italy
    Blood Press Monit 13:153-5. 2008
    ..In a recent guidelines document of the European Society of Hypertension, there is no clear position in favor of one definition over other...
  35. ncbi request reprint Should we prefer different drugs to treat hypertension in older and younger adults? Practical implications of clinical trials: European perspective
    Paolo Verdecchia
    Department of Cardiology, Clinical Research Unit Preventive Cardiology Hospital Santa Maria della Misericordia, Perugia, Italy
    Pol Arch Med Wewn 118:513-6. 2008
    ..Antihypertensive treatment should be embedded within the management of global cardiovascular risk, with the use of charts for stratifying risk based on additional risk factors, target organ damage or additional clinical conditions...
  36. doi request reprint ß-Blockers reduce mortality in patients undergoing high-risk non-cardiac surgery
    Fabio Angeli
    Department of Cardiology, Clinical Research Unit Preventive Cardiology, Hospital Santa Maria della Misericordia, Perugia, Italy
    Am J Cardiovasc Drugs 10:247-59. 2010
    ..However, randomized clinical trials specifically designed to evaluate the effects of beta-blockers on mortality in patients undergoing non-cardiac surgery have yielded conflicting results...
  37. ncbi request reprint Angiotensin-converting enzyme inhibitors and calcium channel blockers for coronary heart disease and stroke prevention
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Hospital R Silvestrini, Localita S Andrea Delle Fratte, 06100, Perugia, Italy
    Hypertension 46:386-92. 2005
    ..However, over and beyond BP reduction, ACEIs appear superior to CCBs for prevention of CHD, whereas CCBs appear superior to ACEIs for prevention of stroke...
  38. doi request reprint The optimal blood pressure target for patients with coronary artery disease
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Unità di Ricerca Clinica Cardiologia Preventiva, Ospedale S Maria della Misericordia, Perugia, Italy
    Curr Cardiol Rep 12:302-6. 2010
    ..The optimal BP target for patients with CAD remains undefined. A reasonable target appears to be in the range of 130-140/80-90 mm Hg. Any further reduction may be safe, but not much productive from a prognostic standpoint...
  39. doi request reprint Pharmacokinetic, pharmacodynamic and clinical evaluation of aliskiren for hypertension treatment
    Gianpaolo Reboldi
    University of Perugia, Department of Internal Medicine, Perugia, Italy
    Expert Opin Drug Metab Toxicol 7:115-28. 2011
    ....
  40. doi request reprint Influence of blood pressure reduction on composite cardiovascular endpoints in clinical trials
    Paolo Verdecchia
    Department of Cardiology, Hospital Santa Maria della Misericordia, Perugia, Italy
    J Hypertens 28:1356-65. 2010
    ..The use of a composite cardiovascular endpoint (CCEP) is frequent in clinical trials. However, the relation between the reduction in blood pressure (BP) and the risk of CCEP is poorly known...
  41. doi request reprint The clinical significance of white-coat and masked hypertension
    Paolo Verdecchia
    Hospital S Maria della Misericordia, Clinical Research Unit Preventive Cardiology, Department of Internal Medicine, University of Perugia, Piazzale G Menghini, Perugia, Italy
    Blood Press Monit 12:387-9. 2007
    ..Severity of target organ damage and incidence of major cardiovascular events are greater in patients with MH than in patients whose BP is normal both inside and outside the doctor's office...
  42. ncbi request reprint Atrial fibrillation in hypertension: predictors and outcome
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Ospedale Silvestrini Università di Perugia, Italy
    Hypertension 41:218-23. 2003
    ..Increased left atrial size predisposes to chronicization of atrial fibrillation...
  43. doi request reprint Tight blood pressure control in diabetes: evidence-based review of treatment targets in patients with diabetes
    Gianpaolo Reboldi
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Curr Cardiol Rep 14:89-96. 2012
    ..Therapeutic inertia (leaving diabetic patients with BP values of 140/90 mmHg or higher) should be avoided at all costs, as this would lead to an unacceptable toll in terms of human lives, suffering, and socioeconomic costs...
  44. doi request reprint Effects of intensive blood pressure reduction on myocardial infarction and stroke in diabetes: a meta-analysis in 73,913 patients
    Gianpaolo Reboldi
    Department of Internal Medicine, University of Perugia, Italy
    J Hypertens 29:1253-69. 2011
    ..There is uncertainty about the impact of this strategy on case-specific events. Thus, we generated estimates of the effects of BP reduction on the risk of myocardial infarction (MI) and stroke in diabetic patients...
  45. ncbi request reprint Short- and long-term incidence of stroke in white-coat hypertension
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Ospedale R Silvestrini, Perugia, Italy
    Hypertension 45:203-8. 2005
    ..In conclusion, WCH was not associated with a definitely increased risk of stroke during the total follow-up period. However, WCH might not be a benign condition for stroke in the long term...
  46. ncbi request reprint White-coat hypertension in adults
    Fabio Angeli
    Department of Cardiovascular Disease, Hospital R Silvestrini, Perugia, Italy
    Blood Press Monit 10:301-5. 2005
    ..suggest a treatment based on life-style measures in the low-risk stratum of patients with white-coat hypertension under the conditions of correct definition, absence of comorbid conditions and target-organ damage, and adequate follow-up..
  47. doi request reprint Comparison between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the risk of myocardial infarction, stroke and death: a meta-analysis
    Gianpaolo Reboldi
    Department of Internal Medicine, University of Perugia, Italy
    J Hypertens 26:1282-9. 2008
    ..To compare the effects of angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors on the risk of myocardial infarction, stroke, cardiovascular mortality and total mortality...
  48. ncbi request reprint Is the development of diabetes with antihypertensive therapy a problem?--Pro
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Ospedale R Silvestrini, Perugia, Italy
    J Clin Hypertens (Greenwich) 8:120-6. 2006
    ..The lowest effective dose of these drugs should be used, plasma glucose should be checked periodically, and concomitant lifestyle measures to prevent diabetes should be implemented with resolution...
  49. ncbi request reprint Validation of the A&D UA-705 device for self-measurement of blood pressure according to the British Hypertension Society protocol
    Paolo Verdecchia
    Department of Cardiology, Hospital R Silvestrini, Perugia, Italy
    Blood Press Monit 11:223-7. 2006
    ..We tested the accuracy of the UA-705 blood pressure semi-automatic monitor...
  50. ncbi request reprint Impact of blood pressure variability on cardiac and cerebrovascular complications in hypertension
    Paolo Verdecchia
    Clinical Research Unit Preventive Cardiology, Hospital R Silvestrini, Perugia, Italy
    Am J Hypertens 20:154-61. 2007
    ..The independent prognostic value of daytime and night-time blood pressure (BP) variability estimated by noninvasive 24-h BP monitoring is unclear...
  51. doi request reprint Multivariable analysis in cerebrovascular research: practical notes for the clinician
    Gianpaolo Reboldi
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Cerebrovasc Dis 35:187-93. 2013
    ..We review the basics of multivariable analyses, what assumptions underline them and how they should be interpreted and evaluated...
  52. ncbi request reprint Calcium channel blockade to prevent stroke in hypertension: a meta-analysis of 13 studies with 103,793 subjects
    Fabio Angeli
    Departments of Cardiovascular Disease and Internal Medicine, Hospital R Silvestrini, Perugia, Italy
    Am J Hypertens 17:817-22. 2004
    ..We undertook a meta-analysis to assess whether calcium channel blockers (CCBs) are associated with a lesser risk of stroke as compared with other antihypertensive drugs...
  53. ncbi request reprint [Antihypertensive therapy and cardiovascular prevention. The role of angiotensin II receptor blockers]
    Paolo Verdecchia
    SC di Cardiologia, Ospedale S Maria della Misericordia, Universita degli Studi di Perugia, Perugia
    G Ital Cardiol (Rome) 8:491-7. 2007
    ..Current indications and contraindications to the use of ARBs in patients with hypertension, heart failure, and diabetic nephropathy should be maintained and probably extended to the entire class of these drugs...
  54. ncbi request reprint New-onset diabetes in treated hypertensive patients
    Paolo Verdecchia
    Dipartimento di Malattie Cardiovascolari, Ospedale R Silvestrini, Localita S Andrea Delle Fratte, 06100 Perugia, Italy
    Curr Hypertens Rep 7:174-9. 2005
    ..The lowest effective dose should be used, and plasma glucose should be carefully monitored...
  55. doi request reprint Masked hypertension: evaluation, prognosis, and treatment
    Fabio Angeli
    Department of Cardiology, Clinical Research Unit Preventive Cardiology, Hospital S Maria della Misericordia, Perugia, Italy
    Am J Hypertens 23:941-8. 2010
    ..MH should be searched for in subjects who appear to be more likely to have this condition. Antihypertensive treatment is envisaged in these subjects, although the associated outcome benefits are still undetermined...
  56. ncbi request reprint Prognostic value of serial electrocardiographic voltage and repolarization changes in essential hypertension: the HEART Survey study
    Paolo Verdecchia
    Clinical Research Unit in Preventive Cardiology, Hospital S Maria della Misericordia, Perugia, Italy
    Am J Hypertens 20:997-1004. 2007
    ..The interpretation of serial electrocardiographic (ECG) changes in hypertensive subjects is uncertain. We tested the hypothesis that serial changes in repolarization and voltage are independent determinants of outcome...
  57. doi request reprint Angiotensin receptor blockers in hypertension. New insights from Japan
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Unità di Ricerca Clinica Cardiologia Preventiva, Ospedale S Maria della Misericordia, Perugia, Italy
    Hypertens Res 33:394-7. 2010
    ..002). The protective effect on the dissecting aneurysm of aorta bordered statistical significance. These data reinforce the notion that the protective effect of angiotensin II inhibition is partly independent of BP reduction...
  58. doi request reprint Pharmacokinetic evaluation and clinical utility of azilsartan medoxomil for the treatment of hypertension
    Fabio Angeli
    Section of Cardiology, AUSL 1 dell Umbria, Perugia, Italy
    Expert Opin Drug Metab Toxicol 9:379-85. 2013
    ..This new agent induces a potent and long-lasting antihypertensive effect. The effective therapeutic antihypertensive dosages of azilsartan medoxomil in humans vary from 40 to 80 mg/day...
  59. ncbi request reprint Meta-Analysis of effectiveness or lack thereof of angiotensin-converting enzyme inhibitors for prevention of heart failure in patients with systemic hypertension
    Fabio Angeli
    Department of Cardiovascular Disease, Hospital R Silvestrini, Perugia, Italy
    Am J Cardiol 93:240-3. 2004
    ..Thus, the hypothesis that ACE inhibitors are superior to other antihypertensive drugs for prevention of CHF in hypertension remains unproven...
  60. ncbi request reprint Validation of the A&D UA-774 (UA-767Plus) device for self-measurement of blood pressure
    Paolo Verdecchia
    Department of Cardiology, R Silvestrini Hospital, Perugia, Italy
    Blood Press Monit 9:225-9. 2004
    ..To determine the accuracy of the UA-774 (UA-767Plus) blood pressure monitor developed by the A&D Company...
  61. ncbi request reprint Echocardiographic left ventricular hypertrophy in hypertension: marker for future events or mediator of events?
    Paolo Verdecchia
    Hospital S Maria della Misericordia, Division of Cardiology, Clinical Research Unit Preventive Cardiology, Perugia, Italy
    Curr Opin Cardiol 22:329-34. 2007
    ..To discuss the most relevant studies on the prognostic impact of echocardiographic left ventricular hypertrophy in hypertension...
  62. ncbi request reprint [Beta-blockers and arterial hypertension. Evidence-based medicine or excessive perseverance?]
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Ospedale S Maria della Misericordia e Università degli Studi di Perugia, Perugia
    G Ital Cardiol (Rome) 8:552-8. 2007
    ..The present review addresses facts and theories related to the actual concern on the role of beta-blockers in the modern management of hypertensive patients...
  63. ncbi request reprint Do angiotensin II receptor blockers increase the risk of myocardial infarction?
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Ospedale R Silvestrini, 06100 Perugia, Italy
    Eur Heart J 26:2381-6. 2005
    ..The uncertainty surrounding safety of angiotensin receptor blockers (ARBs) increased after publication of experimental and clinical studies which suggested an excess risk of myocardial infarction (MI) in people treated with ARBs...
  64. pmc Treatment strategies for osteoarthritis patients with pain and hypertension
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Unità di Ricerca Clinica Cardiologia Preventiva Ospedale S Maria della Misericordia, Perugia, Italy
    Ther Adv Musculoskelet Dis 2:229-40. 2010
    ..These investigational data suggest that naproxcinod is a valuable alternative to NSAIDs and COX-2 inhibitors for treatment of OA patients...
  65. ncbi request reprint Prognostic value of circadian blood pressure changes in relation to differing measures of day and night
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Unità di Ricerca Clinica Cardiologia Preventiva Ospedale S Maria della Misericordia, Perugia, Italy
    J Am Soc Hypertens 2:88-96. 2008
    ..61 to 0.70], 0.64 [95% CI: 0.60 to 0.69], 0.65 [95% CI: 0.61 to 0.70], respectively; P = 0.78). The prognostic value of the diurnal BP changes is comparable when using different clock-dependent or independent definitions of day and night...
  66. ncbi request reprint Changes in cardiovascular risk by reduction of left ventricular mass in hypertension: a meta-analysis
    Paolo Verdecchia
    Department of Cardiovascular Disease, Hospital R Silvestrini, Perugia, Italy
    Am J Hypertens 16:895-9. 2003
    ..The aim of this meta-analysis was to evaluate the prognostic impact of LV hypertrophy regression in hypertension...
  67. ncbi request reprint Does brachial pulse pressure predict coronary events?
    Paolo Verdecchia
    Unita di Ricerca Clinica, Cardiologia Preventiva, Struttura Complessa di Cardiologia, Ospedale R Silvestrini, Perugia, Italy
    Adv Cardiol 44:150-9. 2007
    ..Some data suggest that a wide PP could also represent a direct and independent stimulus for progression of atherosclerosis...
  68. ncbi request reprint Reversal of left ventricular hypertrophy: what have recent trials taught us?
    Paolo Verdecchia
    Department of Cardiovascular Disease, Hospital R Silvestrini University of Perugia, Perugia, Italy
    Am J Cardiovasc Drugs 4:369-78. 2004
    ..However, extrapolation of the results of these studies in terms of class effects could be misleading and should be made with caution...
  69. ncbi request reprint Ambulatory blood pressure monitoring and prognosis in the management of essential hypertension
    Paolo Verdecchia
    Department of Cardiovascular Disease, University of Perugia, Hospital R Silvestrini, Localita S Andrea Delle Fratte, Italy
    Expert Rev Cardiovasc Ther 1:79-89. 2003
    ..Based on available evidence, an operational flow-chart in order to interpret results of ambulatory blood pressure for a better management of these subjects is suggested...
  70. ncbi request reprint Assessment of the optimal daily dose of valsartan in patients with hypertension, heart failure, or both
    Paolo Verdecchia
    Department of Cardiovascular Disease, Hospital R Silvestrini, University of Perugia, S Andrea delle Fratte, 06122 Perugia, Italy
    Clin Ther 26:460-72. 2004
    ..Therefore, it is necessary to determine the ARB dosages that optimize the efficacy/tolerability ratio...
  71. ncbi request reprint Clinical usefulness of ambulatory blood pressure monitoring
    Paolo Verdecchia
    Department of Cardiovascular Disease, University of Perugia, Hospital R Silvestrini, Localita S Andrea Delle Fratte, Perugia, Italy
    J Am Soc Nephrol 15:S30-3. 2004
    ..On the basis of available evidence, an operational flowchart is suggested to interpret results of ABP for better treatment of patients with elevated BP...
  72. ncbi request reprint Ambulatory blood pressure for cardiovascular risk stratification
    Paolo Verdecchia
    Circulation 115:2091-3. 2007
  73. ncbi request reprint Risk of cardiovascular disease in relation to achieved office and ambulatory blood pressure control in treated hypertensive subjects
    Paolo Verdecchia
    Università di Perugia ed Ospedale R Silvestrini, Dipartimento di Malattie Cardiovascolari, Italy
    J Am Coll Cardiol 39:878-85. 2002
    ..We investigated the prognostic impact of 24-h blood pressure control in treated hypertensive subjects...
  74. ncbi request reprint Estimate of white-coat effect and arterial stiffness
    Giovanni de Simone
    Department of Clinical and Experimental Medicine, Federico II University Hospital, School of Medicine, Naples, Italy
    J Hypertens 25:827-31. 2007
    ..This study was designed to assess whether such a difference is associated with impairment of the conduit arterial system...
  75. ncbi request reprint How can we use the results of ambulatory blood pressure monitoring in clinical practice?
    Paolo Verdecchia
    Hypertension 46:25-6. 2005
  76. ncbi request reprint Hypertrophy at ECG and its regression during treatment survey (HEART survey). Rationale, design and baseline characteristics of patients
    Paolo Verdecchia
    ANMCO Research Center, Florence, Italy
    Ital Heart J 4:479-83. 2003
    ..The aim of this study was to determine the prognostic value of baseline ECG LVH and its serial changes in a large cohort of hypertensive patients...
  77. ncbi request reprint Atrial activation analysis by surface P wave and multipolar esophageal recording after cardioversion of persistent atrial fibrillation
    Giuseppe Bagliani
    Cardiology Department, Foligno General Hospital, Foligno, Italy
    Pacing Clin Electrophysiol 26:1178-88. 2003
    ..64, P < 0.001). Much information concerning atrial activation can be obtained by meticulous analysis of the P wave, particularly its terminal part. Multipolar esophageal recording can be used when surface ECG appears unclear...
  78. ncbi request reprint Optimizing the definition of dippers and nondippers: is a 70-86% full glass empty?
    Paolo Verdecchia
    J Hypertens 26:630-2. 2008
  79. ncbi request reprint [The Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation and Treatment of High Blood Pressure: the weapons are ready]
    Paolo Verdecchia
    Rev Esp Cardiol 56:843-7. 2003
    ..The stage is now set for an hard task: their effective implementation in the clinical practice with the aim to decrease cardiovascular morbidity and mortality...
  80. ncbi request reprint Compared with whom? Addressing the prognostic value of ambulatory blood pressure categories
    Paolo Verdecchia
    Hypertension 47:820-1. 2006
  81. ncbi request reprint New-onset diabetes, antihypertensive treatment, and outcome
    Paolo Verdecchia
    Hypertension 50:459-60. 2007
  82. ncbi request reprint Natural history of hypertension subtypes
    Paolo Verdecchia
    Circulation 111:1094-6. 2005
  83. ncbi request reprint The natural history of white-coat hypertension in the long term
    Paolo Verdecchia
    Blood Press Monit 10:65-6. 2005