Francesco Amenta

Summary

Affiliation: University of Camerino
Country: Italy

Publications

  1. ncbi request reprint Treatment with nicardipine protects brain in an animal model of hypertension-induced damage
    Francesco Amenta
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 26:351-61. 2004
  2. ncbi request reprint Pathways of acetylcholine synthesis, transport and release as targets for treatment of adult-onset cognitive dysfunction
    F Amenta
    Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, 62032 Camerino, Italy
    Curr Med Chem 15:488-98. 2008
  3. ncbi request reprint Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent
    Enea Traini
    Centro Ricerche Cliniche, Telemedicina e Telefarmacia Università di Camerino, via Madonna delle Carceri 9, 62032 Camerino MC Italy
    Curr Alzheimer Res 10:1070-9. 2013
  4. doi request reprint The ASCOMALVA trial: association between the cholinesterase inhibitor donepezil and the cholinergic precursor choline alphoscerate in Alzheimer's disease with cerebrovascular injury: interim results
    Francesco Amenta
    Centro Ricerche Cliniche, Scienze del Farmaco e dei Prodotti della Salute, Universita di Camerino, Camerino, Italy
    J Neurol Sci 322:96-101. 2012
  5. ncbi request reprint Effect of treatment with lercanidipine on heart of Cohen-Rosenthal diabetic hypertensive rats
    Francesco Amenta
    Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via Scalzino 3, 62032 Camerino, Italy
    Hypertension 41:1330-5. 2003
  6. doi request reprint Nicardipine use in cerebrovascular disease: a review of controlled clinical studies
    Francesco Amenta
    Clinical Research Centre, Department of Experimental Medicine and Public Health, University of Camerino, 62032 Camerino, Italy
    J Neurol Sci 283:219-23. 2009
  7. ncbi request reprint Arterial hypertension and brain damage--evidence from animal models (review)
    Francesco Amenta
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 25:359-80. 2003
  8. ncbi request reprint Spontaneously hypertensive rat neuroanatomy: applications to pharmacological research
    Francesco Amenta
    Anatomia Umana, Universita di Camerino, 62032 Camerino
    Ital J Anat Embryol 115:13-7. 2010
  9. doi request reprint Nicardipine: a hypotensive dihydropyridine-type calcium antagonist with a peculiar cerebrovascular profile
    Francesco Amenta
    Centro Recherche Cliniche, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 30:808-26. 2008
  10. ncbi request reprint Neurotransmitter receptor expression by peripheral mononuclear cells: possible marker of neuronal damage by exposure to radiations
    Francesco Amenta
    Department of Pharmacological Sciences and Experimental Medicine, Camerino University, Italy
    Cell Mol Biol (Noisy-le-grand) 48:415-21. 2002

Collaborators

Detail Information

Publications92

  1. ncbi request reprint Treatment with nicardipine protects brain in an animal model of hypertension-induced damage
    Francesco Amenta
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 26:351-61. 2004
    ..The demonstration of neuroprotective effect of nicardipine suggests an use of the compound in situations in which hypertension is accompanied by the risk of brain damage...
  2. ncbi request reprint Pathways of acetylcholine synthesis, transport and release as targets for treatment of adult-onset cognitive dysfunction
    F Amenta
    Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, 62032 Camerino, Italy
    Curr Med Chem 15:488-98. 2008
    ....
  3. ncbi request reprint Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent
    Enea Traini
    Centro Ricerche Cliniche, Telemedicina e Telefarmacia Università di Camerino, via Madonna delle Carceri 9, 62032 Camerino MC Italy
    Curr Alzheimer Res 10:1070-9. 2013
    ....
  4. doi request reprint The ASCOMALVA trial: association between the cholinesterase inhibitor donepezil and the cholinergic precursor choline alphoscerate in Alzheimer's disease with cerebrovascular injury: interim results
    Francesco Amenta
    Centro Ricerche Cliniche, Scienze del Farmaco e dei Prodotti della Salute, Universita di Camerino, Camerino, Italy
    J Neurol Sci 322:96-101. 2012
    ....
  5. ncbi request reprint Effect of treatment with lercanidipine on heart of Cohen-Rosenthal diabetic hypertensive rats
    Francesco Amenta
    Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via Scalzino 3, 62032 Camerino, Italy
    Hypertension 41:1330-5. 2003
    ..Treatment with lercanidipine countered hypertension-related cardiac and coronary changes, suggesting that this dihydropyridine-type Ca2+ antagonist may improve heart and coronary structure in diabetes associated with hypertension...
  6. doi request reprint Nicardipine use in cerebrovascular disease: a review of controlled clinical studies
    Francesco Amenta
    Clinical Research Centre, Department of Experimental Medicine and Public Health, University of Camerino, 62032 Camerino, Italy
    J Neurol Sci 283:219-23. 2009
    ....
  7. ncbi request reprint Arterial hypertension and brain damage--evidence from animal models (review)
    Francesco Amenta
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 25:359-80. 2003
    ..Limits and perspectives in the use of animal models for assessing brain damage caused by hypertension and protection from it are discussed...
  8. ncbi request reprint Spontaneously hypertensive rat neuroanatomy: applications to pharmacological research
    Francesco Amenta
    Anatomia Umana, Universita di Camerino, 62032 Camerino
    Ital J Anat Embryol 115:13-7. 2010
    ..Our main studies on cerebrovascular and brain microanatomical changes occurring in SHR and their sensitivity to pharmacological interventions are summarized...
  9. doi request reprint Nicardipine: a hypotensive dihydropyridine-type calcium antagonist with a peculiar cerebrovascular profile
    Francesco Amenta
    Centro Recherche Cliniche, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 30:808-26. 2008
    ....
  10. ncbi request reprint Neurotransmitter receptor expression by peripheral mononuclear cells: possible marker of neuronal damage by exposure to radiations
    Francesco Amenta
    Department of Pharmacological Sciences and Experimental Medicine, Camerino University, Italy
    Cell Mol Biol (Noisy-le-grand) 48:415-21. 2002
    ....
  11. doi request reprint Pharmacokinetics of different formulations of tioctic (alpha-lipoic) acid in healthy volunteers
    Francesco Amenta
    Centro di Ricerche Cliniche, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 30:767-75. 2008
    ....
  12. ncbi request reprint Protective effect of anti-hypertensive treatment on cognitive function in essential hypertension: analysis of published clinical data
    Francesco Amenta
    Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Unità di Ricerche Cliniche, Universita di Camerino, Via Scalzino, 3 62032 Camerino, Italy
    J Neurol Sci 203:147-51. 2002
    ..More extensive investigations could contribute to establishing optimal choice and drug dosage for the treatment of cognitive complications of hypertension...
  13. ncbi request reprint The peripheral dopaminergic system: morphological analysis, functional and clinical applications
    F Amenta
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Italy
    Ital J Anat Embryol 107:145-67. 2002
    ..In spite of the heterogeneity of peripheral systems expressing dopamine receptors, analysis of their localization with appropriate microanatomical techniques may contribute to investigate their role in health and disease...
  14. ncbi request reprint The cholinergic approach for the treatment of vascular dementia: evidence from pre-clinical and clinical studies
    Francesco Amenta
    Clinical Research Unit, Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino, Italy
    Clin Exp Hypertens 24:697-713. 2002
    ..This particular profile would justify reconsideration of the compound in larger controlled clinical trials for the treatment of cognitive dysfunction associated with dementia disorders of vascular origin...
  15. ncbi request reprint Association with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmission
    Francesco Amenta
    Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Via Scalzino 3, 62032 Camerino, Italy
    Mech Ageing Dev 127:173-9. 2006
    ....
  16. ncbi request reprint Quantitative image analysis of choroid and retinal vasculature in SHR: a model of cerebrovascular hypertensive changes?
    Daniele Tomassoni
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, 62032 Camerino, Italy
    Clin Exp Hypertens 24:741-52. 2002
    ..This suggests that analysis of retinal arteries may be predictive of brain intracerebral arteries changes in hypertension...
  17. doi request reprint Neuroprotective effect of treatment with galantamine and choline alphoscerate on brain microanatomy in spontaneously hypertensive rats
    Seyed Khosrow Tayebati
    Section of Human Anatomy, Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    J Neurol Sci 283:187-94. 2009
    ..A wider neuroprotective effect of the cholinergic inhibitor/precursor association was observed. These findings suggest to assess the activity of this cholinergic association in clinical trials...
  18. doi request reprint Influence of dermal exposure to the pyrethroid insecticide deltamethrin on rat brain microanatomy and cholinergic/dopaminergic neurochemistry
    Seyed Khosrow Tayebati
    Department of Experimental Medicine and Public Health, University of Camerino, Italy
    Brain Res 1301:180-8. 2009
    ..The sensitivity of dopaminergic system in our experimental model suggests that dermal exposure to deltamethrin could represent a risk factor for Parkinson's disease...
  19. ncbi request reprint Neuroprotective effect of treatment with calcium antagonists on hypertensive retina
    Maurizio Sabbatini
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, 62032 Camerino, Italy
    Clin Exp Hypertens 24:727-40. 2002
    ..The demonstration of a neuroprotective effect of Ca2+ antagonists on retina of SHR suggests that these compounds might protect to a some extent retina from hypertensive injury...
  20. ncbi request reprint Effect of treatment with the cholinesterase inhibitor rivastigmine on vesicular acetylcholine transporter and choline acetyltransferase in rat brain
    Seyed Khosrow Tayebati
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 26:363-73. 2004
    ..The observation of a greater expression of this cholinergic marker in SHR suggest that AChE inhibition may provide beneficial effects on cholinergic neurotransmission in an animal model of VaD...
  21. ncbi request reprint Effect of treatment with choline alphoscerate on hippocampus microanatomy and glial reaction in spontaneously hypertensive rats
    Daniele Tomassoni
    Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Camerino, Italy
    Brain Res 1120:183-90. 2006
    ..The observation that treatment with choline alphoscerate attenuates the extent of glial reaction in the hippocampus of SHR suggests also that the compound may afford neuroprotection in this animal model of vascular brain damage...
  22. doi request reprint Expression of aquaporins 1 and 4 in the brain of spontaneously hypertensive rats
    Daniele Tomassoni
    Anatomia Umana, Scuola di Scienze del Farmaco e dei Prodotti della Salute, Universita di Camerino, Camerino, Italy
    Brain Res 1325:155-63. 2010
    ..This situation in case of an acute or excessively elevated rise of blood pressure can promote BBB changes causing the brain damage occurring in this animal model of hypertension...
  23. ncbi request reprint Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats
    Daniele Tomassoni
    Scuola di Bioscienze e Biotecnologie, Universita di Camerino, Camerino, Italy
    Curr Alzheimer Res 9:120-7. 2012
    ....
  24. ncbi request reprint The cerebral cortex of spontaneously hypertensive rats: a quantitative microanatomical study
    Fiorenzo Mignini
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 26:287-303. 2004
    ....
  25. ncbi request reprint Increased expression of glial fibrillary acidic protein in the brain of spontaneously hypertensive rats
    Daniele Tomassoni
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 26:335-50. 2004
    ....
  26. ncbi request reprint Effect of different dihydropyridine-type Ca2+ antagonists on left ventricle hypertrophy and coronary changes in spontaneously hypertensive rats
    Daniele Tomassoni
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Italy
    J Cardiovasc Pharmacol 41:544-52. 2003
    ..The evaluation of specific properties of dihydropyridines on hypertensive end-organ damage may contribute to better choices depending on clinical situations...
  27. doi request reprint Dopamine, vesicular transporters and dopamine receptor expression and localization in rat thymus and spleen
    Fiorenzo Mignini
    Anatomia Umana, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Camerino, Italy
    J Neuroimmunol 206:5-13. 2009
    ..Based on the microanatomical localization of dopaminergic markers investigated, a role of dopamine in maturation and selection of lymphocytes and activation of immune responses is suggested...
  28. doi request reprint Late and early onset dementia: what is the role of vascular factors? A retrospective study
    Anna Carotenuto
    Centro Ricerche Cliniche, Scuola di Scienze del Farmaco e dei Prodotti della Salute, Universita di Camerino, Camerino, Italy
    J Neurol Sci 322:170-5. 2012
    ..This study has assessed the presence of vascular brain lesions and risk factors in subjects with diagnosis of AD and their influence on the disease course both in Late Onset Dementia (LOD) and in Early Onset Dementia (EOD)...
  29. doi request reprint Effect of choline-containing phospholipids on brain cholinergic transporters in the rat
    Seyed Khosrow Tayebati
    Anatomia Umana, Scienze del Farmaco e dei Prodotti della Salute, Universita di Camerino, 62032 Camerino, Italy
    J Neurol Sci 302:49-57. 2011
    ..This for assessing their place if any in pharmacotherapy of dementia disorders characterized by diminished cholinergic tone...
  30. doi request reprint Nimodipine and its use in cerebrovascular disease: evidence from recent preclinical and controlled clinical studies
    Daniele Tomassoni
    Centro Ricerche Cliniche, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 30:744-66. 2008
    ..In conclusion, nimodipine is a safe drug with an important place in pharmacotherapy and with the main documentation for reduction in the severity of neurological deficits resulting from vasospasm in SAH patients...
  31. ncbi request reprint Comparative crossover, randomized, open-label bioequivalence study on the bioequivalence of two formulations of thioctic acid in healthy volunteers
    Fiorenzo Mignini
    Centro di Ricerche Cliniche, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 29:575-86. 2007
    ..The comparison between males and females showed no significant difference for the two drug treatment...
  32. ncbi request reprint Cerebrovascular and brain microanatomy in spontaneously hypertensive rats with streptozotocin-induced diabetes
    Daniele Tomassoni
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 26:305-21. 2004
    ..These results support the view that hypertension and diabetes affect the structure of cerebrovascular tree and of brain and that association of the two diseases results in an increased risk of target-organ damage, involving brain...
  33. ncbi request reprint Effects of dihydropyridine-type Ca2+ antagonists on the renal arterial tree in spontaneously hypertensive rats
    Maurizio Sabbatini
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina, Università of Camerino, 62032 Camerino, Italy
    J Cardiovasc Pharmacol 39:39-48. 2002
    ..Hydralazine countered luminal narrowing only. Dihydropyridines exerted renal vasocilatory activity primarily on resistance arteries, being lercanidipine the only compound active on small sized arteries...
  34. ncbi request reprint Effect of nicardipine treatment on the expression of neurofilament 200 KDa immunoreactivity in the brain of spontaneously hypertensive rats
    M Sabbatini
    Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, , Italy
    Clin Exp Hypertens 23:127-41. 2001
    ..The possibility that rescued P-NFP immunoreactivity by treatment with nicardipine depends on improved brain perfusion caused by the compound and/or by countering neuronal Ca2+ overload is discussed...
  35. doi request reprint Astrogliosis in the brain of obese Zucker rat: a model of metabolic syndrome
    Daniele Tomassoni
    School of Bioscience and Biotechnology, University of Camerino, 62032 Camerino, Italy
    Neurosci Lett 543:136-41. 2013
    ..The identification of neurodegenerative changes in OZRs may represent the first step for better characterizing neuronal involvement in this model of MetS and possible treatment for countering it...
  36. doi request reprint Pharmacokinetics and bioequivalence study of two tablet formulations of lovastatin in healthy volunteers
    Fiorenzo Mignini
    Centro di Ricerche Cliniche, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 30:95-108. 2008
    ..The high inter-subject variability of parameters investigated indicate the need of appropriate sample size in pharmacokinetics studies with lovastatin...
  37. ncbi request reprint Single-dose, randomized, crossover bioequivalence study of amlodipine maleate versus amlodipine besylate in healthy volunteers
    Fiorenzo Mignini
    Centro di Ricerche Cliniche, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 29:539-52. 2007
    ..Hence, the two salts investigated could be used interchangeably in clinical practice...
  38. ncbi request reprint Microanatomical changes of intracerebral arteries in spontaneously hypertensive rats: a model of cerebrovascular disease of the elderly
    M Sabbatini
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, , Via Scalzino 3, 62032, Camerino, Italy
    Mech Ageing Dev 122:1257-68. 2001
    ..The possibility that microanatomical changes developed in intracerebral arteries of SHR may represent a model of cerebrovascular disease of the elderly is discussed...
  39. ncbi request reprint Protective effect of treatment with nicardipine on cerebrovascular tree of spontaneously hypertensive rats
    M Sabbatini
    Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, , Italy
    Clin Exp Hypertens 23:143-55. 2001
    ..This property may be useful in avoiding generalized or exaggerated cerebrovascular dilatation in hypertension which could be accompanied by impaired brain perfusion...
  40. ncbi request reprint The Psychological General Well-Being Index (PGWBI) for assessing stress of seafarers on board merchant ships
    Anna Carotenuto
    Centre for Clinical Research, Telemedicine and Telepharmacy, University of Camerino, Camerino, Italy Department of Study and Research, International Radio Medical Centre CIRM, Rome, Italy
    Int Marit Health 64:215-20. 2013
    ..The choice of the tools for this evaluation is challenging, and a common basic standard usable in a large scale should be identified...
  41. ncbi request reprint Age-related changes of muscarinic cholinergic receptor subtypes in the striatum of Fisher 344 rats
    Seyed Khosrow Tayebati
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, 62032 Camerino, Italy
    Exp Gerontol 39:217-23. 2004
    ..In view of this, the identification of age-related changes of striatal muscarinic receptor subtypes may contribute to develop cholinergic strategies to counter cholinergic neurotransmission changes occurring with aging...
  42. ncbi request reprint Morphological and conduction changes in the sciatic nerve of spontaneously hypertensive rats
    Daniele Tomassoni
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via Scalzino, 3, 62032 Camerino, Italy
    Neurosci Lett 362:131-5. 2004
    ..Our findings support the hypothesis that arterial hypertension may represent a risk factor of neuropathy...
  43. ncbi request reprint Effect of antihypertensive treatment on peripheral nerve vasculature in spontaneously hypertensive rats
    M Sabbatini
    Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, , Italy
    Clin Exp Hypertens 23:157-66. 2001
    ..Further work is in progress to identify the functional relevance of microanatomical observations of the present study...
  44. ncbi request reprint Influence of treatment with Ca(2+) antagonists on cerebral vasculature of spontaneously hypertensive rats
    M Sabbatini
    Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Sezione di Anatomia Umana, , Via Scalzino, 62032 Camerino, Italy
    Mech Ageing Dev 122:795-809. 2001
    ..This activity of lercanidipine on small-sized intracerebral arteries might represent an interesting property for the treatment of hypertensive brain damage with concomitant ischemia...
  45. ncbi request reprint Hypertensive brain damage: comparative evaluation of protective effect of treatment with dihydropyridine derivatives in spontaneously hypertensive rats
    M Sabbatini
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, , Via Scalzino, 62032, Camerino, Italy
    Mech Ageing Dev 122:2085-105. 2001
    ..Compared with nimodipine, lercanidipine induced a more effective decrease of SBP. This may represent an advantage in the treatment of hypertension with risk of brain damage...
  46. doi request reprint Spontaneously hypertensive rat as a model of vascular brain disorder: microanatomy, neurochemistry and behavior
    Seyed Khosrow Tayebati
    School of Medicinal Sciences and Health Products, University of Camerino, Camerino, Italy
    J Neurol Sci 322:241-9. 2012
    ..This paper reviews the main microanatomical, neurochemical and behavioral characteristics of SHR with particular reference as an animal model of brain vascular injury...
  47. ncbi request reprint Muscarinic cholinergic receptor subtypes in cerebral cortex of Fisher 344 rats: a light microscope autoradiography study of age-related changes
    Seyed Khosrow Tayebati
    Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Via Scalzino, 3, 62032 Camerino, Italy
    Mech Ageing Dev 127:115-22. 2006
    ..This may account for the difficulty in obtaining relevant results in manipulating cholinoceptors to counter age-related impairment of cholinergic system...
  48. ncbi request reprint Identification of adenosine A1 and A3 receptor subtypes in rat pial and intracerebral arteries
    Maria Antonietta Di Tullio
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via Scalzino, 3, 62032 Camerino, Italy
    Neurosci Lett 366:48-52. 2004
    ..The identification of cerebrovascular A1 and A3 adenosine receptor subtypes may stimulate further research for detailing the mechanism(s) of regulation of cerebral circulation by adenosine...
  49. ncbi request reprint Immunochemical and immunocytochemical characterization of cholinergic markers in human peripheral blood lymphocytes
    Seyed K Tayebati
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via Scalzino 3, 62032 Camerino, Italy
    J Neuroimmunol 132:147-55. 2002
    ..The characterization of these cholinergic markers may also contribute to define if their evaluation can be used for assessing the status of brain cholinergic system...
  50. doi request reprint Neuroprotective activity of thioctic Acid in central nervous system lesions consequent to peripheral nerve injury
    Daniele Tomassoni
    School of Bioscience and Biotechnology, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Italy
    Biomed Res Int 2013:985093. 2013
    ..These findings suggest a neuroprotective activity of thioctic acid on CNS lesions consequent to CCI and that the compound may represent a therapeutic option for entrapment neuropathies. ..
  51. ncbi request reprint Bioequivalence study of nicardipine solution versus nicardipine tablets
    Fiorenzo Mignini
    Sezione di Anatomia Umana, Unità di Ricerche Cliniche, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 26:375-86. 2004
    ....
  52. ncbi request reprint Age-related changes of dopamine receptors in the rat hippocampus: a light microscope autoradiography study
    F Amenta
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via Scalzino, 3, 62032, Camerino, Italy
    Mech Ageing Dev 122:2071-83. 2001
    ..These findings support the hypothesis of an involvement of dopaminergic system in behavioural abnormalities or psychosis occurring in ageing...
  53. ncbi request reprint Localisation of dopamine D2-like receptors in pulmonary artery of the human and rabbit but not of the rat
    Y Kobayashi
    Sezione di Anatomia Umana, Universita di Camerino, Italy
    Eur J Pharmacol 261:229-36. 1994
    ..Comparison of the localisation of dopamine D2-like receptor sites and of the sympathetic neuroeffector plexus in the pulmonary artery, suggests a possible prejunctional localisation of these sites...
  54. ncbi request reprint Changes of retinal neurons and glial fibrillary acid protein immunoreactive astrocytes in spontaneously hypertensive rats
    M Sabbatini
    Section of Human Anatomy, Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Camerino, Italy
    J Hypertens 19:1861-9. 2001
    ..The influence of arterial hypertension on retinal neurons and glial fibrillary acid protein (GFAP) immunoreactive astrocytes was investigated in spontaneously hypertensive rats (SHRs)...
  55. doi request reprint Vesicular acetylcholine transporter (VAChT) in the brain of spontaneously hypertensive rats (SHR): effect of treatment with an acetylcholinesterase inhibitor
    S K Tayebati
    Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 30:732-43. 2008
    ..The possibility that cholinergic neurotransmission enhancement may represent a therapeutic strategy in cerebrovascular disease is discussed...
  56. ncbi request reprint The dopaminergic system in hypertension
    F Amenta
    Dipartimento di Scienze Cardiovascolari e Respiratorie, Universita La Sapienza, Roma, Italy
    Clin Exp Hypertens 23:15-24. 2001
    ..A better knowledge of molecular bases of these changes may contribute to the development of specific therapeutic approaches in the future...
  57. ncbi request reprint Identification of dopamine plasma membrane and vesicular transporters in human peripheral blood lymphocytes
    F Amenta
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via Scalzino, 3, 62032, Camerino, Italy
    J Neuroimmunol 117:133-42. 2001
    ..In view of this assessment of lymphocyte DAT and VMAT transporters can be considered for identifying pathologies characterized by impaired dopaminergic neurotransmission...
  58. ncbi request reprint Treatment of cognitive dysfunction associated with Alzheimer's disease with cholinergic precursors. Ineffective treatments or inappropriate approaches?
    F Amenta
    Clinical Research Unit, Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Scalzino 3, 62032, Camerino, Italy
    Mech Ageing Dev 122:2025-40. 2001
    ..Although some positive results cannot be generalized due to the small numbers of patients studied, they probably would justify reconsideration of the most promising molecules in larger carefully controlled trials...
  59. ncbi request reprint Peripheral blood lymphocytes muscarinic cholinergic receptor subtypes in Alzheimer's disease: a marker of cholinergic dysfunction?
    S K Tayebati
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via Scalzino, 3, 62032 Camerino, Italy
    J Neuroimmunol 121:126-31. 2001
    ..Assessment of lymphocyte muscarinic receptor subtypes may contribute to characterization of cholinergic impairment in AD...
  60. ncbi request reprint Localization of the m5 muscarinic cholinergic receptor in rat circle of Willis and pial arteries
    S K Tayebati
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via Scalzino 3, 62032 Camerino, Italy
    Neuroscience 122:205-11. 2003
    ..In view of the peculiar localization in cerebral vessels, handling of the muscarinic m5 receptor may be considered as an approach in the treatment of cerebrovascular disease...
  61. ncbi request reprint Astrocyte changes in aging cerebral cortex and hippocampus: a quantitative immunohistochemical study
    F Amenta
    Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Italy
    Microsc Res Tech 43:29-33. 1998
    ..The possible significance of hyperplasia and hypertrophy of GFAP-immunoreactive astrocytes in the frontal cortex and in the CA1 subfield of the hippocampus of aged rats is discussed...
  62. ncbi request reprint Pharmacological characterization and autoradiographic localization of dopamine receptors in the rat adrenal medulla
    P Barili
    Istituto di Farmacologia, Universita di Camerino, Italy
    Eur J Pharmacol 310:129-35. 1996
    ..These receptors are probably involved in the modulation of catecholamine release from chromaffin cells, as documented by functional studies...
  63. ncbi request reprint Density and localization of calcium channels of the L-type in human pulmonary artery
    F Amenta
    Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Italy
    Clin Exp Hypertens 20:389-402. 1998
    ..The presence of Ca2+ channels of the L-type in human pulmonary artery suggests that their pharmacological manipulation may be considered in the treatment of pulmonary hypertension...
  64. ncbi request reprint Occupancy by oral administration of nicardipine of L-type calcium channels in rat brain
    F Amenta
    Dipartimento di Scienze Farmacologiche e Medicina Sperimantale, Universita di Camerino, Italy
    Clin Exp Hypertens 23:117-25. 2001
    ..The possible clinico-therapeutic relevance of this observation is discussed...
  65. pmc Efficacy of memantine, donepezil, or their association in moderate-severe Alzheimer's disease: a review of clinical trials
    Ivana Molino
    Centro Ricerche Cliniche, Telemedicina e Telefarmacia, Universita di Camerino, via Madonna delle Carceri 9, 62032 Camerino, Italy
    ScientificWorldJournal 2013:925702. 2013
    ..High doses of the AChE-I donepezil were licensed in the USA for moderate-severe AD, and the association AChE/ChE-Is plus memantine was proposed for AD at this stage...
  66. ncbi request reprint Muscarinic cholinergic receptor subtypes in the hippocampus of aged rats
    Seyed Khosrow Tayebati
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via Scalzino 3, 62032, Camerino, Italy
    Mech Ageing Dev 123:521-8. 2002
    ....
  67. ncbi request reprint Dopamine and vascular dynamics control: present status and future perspectives
    Seyed Khosrow Tayebati
    Human Anatomy Section, School of Drug Sciences and Health Products, University of Camerino, 62032 Camerino, Italy
    Curr Neurovasc Res 8:246-57. 2011
    ....
  68. ncbi request reprint Psychological consequences in victims of maritime piracy: the Italian experience
    Antonio Rosario Ziello
    Clinical Research, Telemedicine and Telepharmacy Centre, University of Camerino, Camerino, Italy
    Int Marit Health 64:136-41. 2013
    ..This study has assessed psychological consequences of kidnapping in a groupof Italian seafarers held in captivity from 7 to 10 months...
  69. ncbi request reprint Survey on food hygiene knowledge on board ships
    Iolanda Grappasonni
    School of Pharmacy, Centre for Clinical Research, Telemedicine and Telepharmacy, University of Camerino, Camerino, Italy
    Int Marit Health 64:160-7. 2013
    ..The aim of the study was to evaluate the knowledge and attitudes on food hygiene in seafarers...
  70. pmc Brain activity of thioctic Acid enantiomers: in vitro and in vivo studies in an animal model of cerebrovascular injury
    Daniele Tomassoni
    School of Biosciences and Biotechnologies, University of Camerino, 62032 Camerino, Italy
    Int J Mol Sci 14:4580-95. 2013
    ..The more pronounced effect of (+)-thioctic acid observed in this study may have practical therapeutic implications worthy of being investigated in further preclinical and clinical studies...
  71. ncbi request reprint (Neuro)transmitter systems in circulating immune cells: a target of immunopharmacological interventions?
    Seyed Khosrow Tayebati
    Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, 62032 Camerino, Italy
    Curr Med Chem 15:3228-47. 2008
    ..The regulatory role of different families of (neuro)transmitters (catecholamines, 5-hydroxytryptamine, acetylcholine, histamine and neuropeptides) in modulating levels of immune mediators or specific immune responses is discussed...
  72. doi request reprint "Reactive" response evaluation of primary human astrocytes after methylmercury exposure
    Giuseppe A Malfa
    Department of Drug Sciences, Biochemistry Section, University of Camerino, Camerino, Italy
    J Neurosci Res 92:95-103. 2014
    ....
  73. ncbi request reprint Recommendations for assessing water quality and safety on board merchant ships
    Iolanda Grappasonni
    School of Pharmacy, Centre for Clinical Research, Telemedicine and Telepharmacy, University of Camerino, Camerino, Italy
    Int Marit Health 64:154-9. 2013
    ..This paper has reviewed the main regulations for the control of water safety and qualityon board ships and presents some practical recommendations for keeping water healthy and safe in passenger and cargo merchant ships...
  74. ncbi request reprint Dopamine plasma membrane transporter (DAT) in rat thymus and spleen: an immunochemical and immunohistochemical study
    F Mignini
    Anatomia Umana, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Via Scalzino 3, 62032 Camerino, Italy
    Auton Autacoid Pharmacol 26:183-9. 2006
    ..It cannot be excluded a different activity of dopamine in primary and secondary immune organs, such as maturation and selection of lymphocytes and activation of immune responses in the spleen...
  75. ncbi request reprint [Arterial hypertension and cognitive deficit]
    Cristina Paglieri
    Centro per lo Studio e la Terapia dell Ipertensione Arteriosa, Ospedale San Vito, Dipartimento di Medicina Interna e Oncologia Sperimentale, Universita degli Studi di Torino
    Ann Ital Med Int 19:163-70. 2004
    ..It would be important to study hypertensive patients, above all young asymptomatic hypertensives, even about cognitive functions, to prevent and consider cognitive decline and effective organ damage...
  76. ncbi request reprint Arterial hypertension and cognitive dysfunction in physiologic and pathologic aging of the brain
    Alessia Lanari
    Section of Neurology, University of Perugia, Perugia, Italy
    Am J Geriatr Cardiol 16:158-64. 2007
    ..Different and probably converging pathophysiologic mechanisms explain the role of arterial hypertension in causing cognitive dysfunction in pathologic aging of the brain, specifically, vascular dementia and Alzheimer's disease...
  77. ncbi request reprint Arterial hypertension: a cause of cognitive impairment and of vascular dementia
    Cristina Paglieri
    Centro di Ipertensione Arteriosa, Ospedale San Vito, Universita di Torino, Torino, Italy
    Clin Exp Hypertens 26:277-85. 2004
    ....
  78. ncbi request reprint Effect of lercanidipine on kidney microanatomy in Cohen-Rosenthal diabetic hypertensive rats
    Talma Rosenthal
    Department of Physiology and Pharmacology, Hypertension Research Unit, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Cardiovasc Pharmacol Ther 12:145-52. 2007
    ..Lercanidipine also had beneficial effects on the renal vasculature, suggesting that the compound may be considered for treating hypertension associated with diabetes...
  79. ncbi request reprint Synthesis of 1-methyl-5-(pyrazol-3- and -5-yl- and 1, 2, 4-triazol-3- and 5-yl)-1, 2, 3, 6-tetrahydropyridine derivatives and their evaluation as muscarinic receptor ligands
    Maria Rosaria Del Giudice
    Laboratorio di Chimica del Far maco, Istituto Superiore di Sanita, Rome, Italy
    Arch Pharm (Weinheim) 336:143-54. 2003
    ..Compounds 5 l and 6 i good M(1) and M(3) antagonistic properties in vitro and were devoid of cholinergic side effects in vivo...
  80. ncbi request reprint Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation?
    Lucilla Parnetti
    Clinica Neurologica, Dipartimento di Specialità Medico Chirurgiche e Sanità Pubblica, Universita di Perugia, Perugia, Italy
    J Neurol Sci 257:264-9. 2007
    ..However, they probably would justify reconsideration of the most promising molecules in larger carefully controlled studies...
  81. ncbi request reprint Expression of peripheral blood lymphocyte muscarinic cholinergic receptor subtypes in airway hyperresponsiveness
    Alberto Ricci
    Dipartimento di Scienze Cardiovascolari e Respiratorie, Universita La Sapienza, Ospedale Carlo Forlanini, Piazza C Forlanini, 00151, Rome, Italy
    J Neuroimmunol 129:178-85. 2002
    ..The demonstration of a different expression of lymphocyte muscarinic receptors in asthma suggests that cholinergic system may participate to a molecular framework influencing immune functions in asthma...
  82. ncbi request reprint Neuronal populations of rat cerebral cortex and hippocampus expressed a higher density of L-type Ca 2+ channel than corresponding cerebral vessels
    Alberto Ricci
    Dipartimento di Scienze Cardiovascolari e Respiratorie, Universita La Sapienza, 00160 Roma, Italy
    Clin Exp Hypertens 24:715-26. 2002
    ..This may account for more pronounced neuronal than vascular effects after pharmacological manipulation of cerebral Ca2+ channels...
  83. ncbi request reprint Glial fibrillary acidic protein immunoreactive astrocytes in developing rat hippocampus
    Assia Catalani
    Dipartimento di Fisiologia Umana e Farmacologia, Universita La Sapienza, P le A Moro 5, 00185, Rome, Italy
    Mech Ageing Dev 123:481-90. 2002
    ..At 5 months of age, there are still dynamic changes in the mature astrocytes, which become slender and thinner probably as a response to the increased volume of hippocampus noticeable at this age...
  84. ncbi request reprint Neurotransmitter deficits in behavioural and psychological symptoms of Alzheimer's disease
    Alessia Lanari
    Dipartimento di Neuroscienze, Universita di Perugia, Perugia, Italy
    Mech Ageing Dev 127:158-65. 2006
    ..On the site of psychotropic drugs, atypical or novel antipsychotics represent the reference drugs for treating BPSD, whereas classic antipsychotic drugs for their profile and the potential side effects should be avoided...
  85. ncbi request reprint Astroglial-conditioned media and growth factors modulate proliferation and differentiation of astrocytes in primary culture
    Vincenzo Bramanti
    Section of Biochemistry and Molecular Biology, Department of Chemical Sciences, University of Catania, Viale Andrea Doria, 6, Catania, Italy
    Neurochem Res 32:49-56. 2007
    ....
  86. ncbi request reprint Stroke prevention and statin treatment
    Lucilla Parnetti
    Department of Neuroscience, University of Perugia, Perugia, Italy
    Clin Exp Hypertens 28:335-44. 2006
    ..In patients with prior strokes, statins reduce the incidence of coronary events, but it is not yet proven if drugs of this class actually reduce the incidence of recurrent strokes in terms of secondary prevention...
  87. ncbi request reprint Vesicular monoamine transporter 1 mediates dopamine secretion in rat proximal tubular cells
    Agnes Maurel
    Institut National de la Santé et de la Recherche Médicale U858 and Université Toulouse III, Institut de Medecine Moleculaire de Rangueil, Toulouse, France
    Am J Physiol Renal Physiol 292:F1592-8. 2007
    ..These data represent the first step toward the comprehension of the role of this transporter in renal dopamine handling and its involvement in pathological situations...
  88. ncbi request reprint Changes in muscarinic cholinergic receptor expression in human peripheral blood lymphocytes in allergic rhinitis patients
    Alberto Ricci
    Dipartimento di Scienze Cardiovascolari e Respiratorie, Universita di Roma La Sapienza, Rome, Italy
    Pulm Pharmacol Ther 21:79-87. 2008
    ..Dysfunction of the upper and lower airways frequently coexist, and they appear to share key elements of pathogenesis...
  89. ncbi request reprint Age-related changes of dopamine receptor protein immunoreactivity in the rat mesenteric vascular tree
    Alberto Ricci
    Dipartimento di Scienze Cardiovascolari e Respiratorie, Universita La Sapienza, Rome, Italy
    Mech Ageing Dev 123:537-46. 2002
    ....
  90. ncbi request reprint Neurotrophin and neurotrophin receptor protein expression in the human lung
    Alberto Ricci
    Dipartimento di Scienze Cardiovascolari e Respiratorie, Universita di Roma La Sapienza, Ospedale Sant Andrea, Via di Grottarossa, 1035 1039, 00189 Rome, Italy
    Am J Respir Cell Mol Biol 30:12-9. 2004
    ..The widespread expression of NTs and their receptors in different components of the lung suggests that these factors may contribute to regulate cell function in human lung...
  91. ncbi request reprint Dopamine D4 receptor expression in rat kidney: evidence for pre- and postjunctional localization
    Alberto Ricci
    Dipartimento di Scienze Cardiovascolari e Respiratorie, Universita La Sapienza, Roma, Italy
    J Histochem Cytochem 50:1091-6. 2002
    ..This suggests that the dopamine D4 receptor may be involved in the control of neurotransmitter release and in renal hemodynamic and tubule function...
  92. ncbi request reprint Treatment of Alzheimer's disease: from pharmacology to a better understanding of disease pathophysiology
    Giorgio Silvestrelli
    Section of Neurology, Department of Medical and Surgical Specialisties and Public Health, University of Perugia, Ospedale Silvestrini, 06156 Perugia, Italy
    Mech Ageing Dev 127:148-57. 2006
    ..This paper reviews the main symptomatic strategies available for treating AD and future strategies for improving our therapeutic approach to AD...