Research Topics
| Maria P AmatoSummaryAffiliation: University of Florence Country: Italy Publications
| Collaborators
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Detail Information
Publications
The costs of multiple sclerosis: a cross-sectional, multicenter cost-of-illness study in ItalyMaria Pia Amato
Department of Neurological Sciences, University of Florence, Italy
J Neurol 249:152-63. 2002..As costs increase with disease progression, these findings suggest that treatment efforts should focus on patients in the early stages of MS, in order to slow down disease progression...- The Rao's Brief Repeatable Battery and Stroop Test: normative values with age, education and gender corrections in an Italian populationM P Amato
Department of Neurology, University of Florence, Viale Morgagni, 85 50134 Florence, Italy
Mult Scler 12:787-93. 2006..Increasing age was associated with worse performance on the ST in version A, and on the SRT-LTS, SRT-CLTR and WLG in version B. Our data can improve the applicability of the BRB for both clinical and research purposes... - Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 yearsM P Amato
Department of Neurology, University of Florence, Viale Morgagni, 85, Florence, Italy 50134
Arch Neurol 58:1602-6. 2001..To reassess, in a cohort of patients with early-onset multiple sclerosis, the long-term evolution of cognitive deficits, their relationship to the disease's clinical progression, and their effects on daily life... - Multiple sclerosis-related cognitive changes: a review of cross-sectional and longitudinal studiesMaria Pia Amato
Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
J Neurol Sci 245:41-6. 2006..The aim of this paper is to provide a review of existing cross-sectional and longitudinal studies on cognitive deterioration in MS... - Early prediction of the long term evolution of multiple sclerosis: the Bayesian Risk Estimate for Multiple Sclerosis (BREMS) scoreRoberto Bergamaschi
Multiple Sclerosis Centre, Department of Clinical Neurology, Neurological Institute C Mondino, Via Mondino 2, 27100 Pavia, Italy
J Neurol Neurosurg Psychiatry 78:757-9. 2007..To propose a simple tool for early prediction of unfavourable long term evolution of multiple sclerosis (MS)... - Pregnancy and fetal outcomes after Glatiramer Acetate exposure in patients with multiple sclerosis: a prospective observational multicentric studyMarta Giannini
Department of Neurology, University of Florence, Florence, Italy
BMC Neurol 12:124. 2012..abstract:.. - Association of MRI metrics and cognitive impairment in radiologically isolated syndromesM P Amato
Department of Neurology, University of Florence, Florence, Italy
Neurology 78:309-14. 2012.... - Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patientsValentina Durastanti
Department of Neurological Sciences, University La Sapienza, Viale dell Universita, 30, 00185, Rome, Italy
J Transl Med 9:42. 2011..The aim of the study was to investigate the dynamic profile of neopterin and kyn/trp ratio in patients with relapsing remitting multiple sclerosis (RRMS) treated with two different doses of IFNβ-1a over a period of 24 months... - Changes in magnetic resonance imaging disease measures over 3 years in mildly disabled patients with relapsing-remitting multiple sclerosis receiving interferon β-1a in the COGnitive Impairment in MUltiple Sclerosis (COGIMUS) studyStefano Bastianello
National Neurological Institute, C Mondino Foundation, Pavia, Italy
BMC Neurol 11:125. 2011..In clinical trials, MRI has been found to detect treatment effects with greater sensitivity than clinical measures; however, clinical and MRI outcomes tend to correlate poorly... - Clinical outcome measures in multiple sclerosisMaria Pia Amato
Department of Neurology, University of Florence, Florence, Italy
J Neurol Sci 259:118-22. 2007..To date, no single measure has emerged as the ideal outcome measure: the main advantages and disadvantages of currently available measurement tools are discussed... - Association of neocortical volume changes with cognitive deterioration in relapsing-remitting multiple sclerosisMaria Pia Amato
Department of Neurology, University of Florence, Viale Morgagni, 85 50134 Florence, Italy
Arch Neurol 64:1157-61. 2007.... - Cognitive changes in multiple sclerosisMaria Pia Amato
Department of Neurology, University of Florence, Viale Morgagni, 85 50134 Florence, Italy
Expert Rev Neurother 8:1585-96. 2008..In this article, we review the current knowledge on CD in MS and highlight areas of special importance for future research in the field... - Cognitive and psychosocial features of childhood and juvenile MSM P Amato
Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
Neurology 70:1891-7. 2008..To assess the impact of multiple sclerosis (MS) on cognitive and psychosocial functioning in childhood and juvenile cases... - Cognitive assessment and quantitative magnetic resonance metrics can help to identify benign multiple sclerosisM P Amato
Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
Neurology 71:632-8. 2008..Moreover, no paraclinical markers are currently available to reliably identify patients who will remain benign in the long term... - Cognitive impairment in early stages of multiple sclerosisMaria Pia Amato
Department of Neurology, University of Florence, Florence, Italy
Neurol Sci 31:S211-4. 2010..Early treatment with disease-modifying drugs that can contain the disease burden in the brain seems to be highly advisable in order to prevent or delay the development of cognitive impairment... - Relevance of cognitive deterioration in early relapsing-remitting MS: a 3-year follow-up studyMaria P Amato
Department of Neurology, University of Florence, Italy
Mult Scler 16:1474-82. 2010..To assess longitudinally cognitive functioning in relapsing-remitting multiple sclerosis (RRMS) patients and its relationship with clinical and MRI variables... - Cognitive and psychosocial features in childhood and juvenile MS: two-year follow-upM P Amato
Department of Neurology, University of Florence, Viale Morgagni 85, Florence, Italy
Neurology 75:1134-40. 2010..To assess the evolution of cognitive and psychosocial functioning in a cohort of childhood and juvenile multiple sclerosis (MS) cases after a mean period of 2 years had elapsed since baseline evaluation... - Pregnancy and fetal outcomes after interferon-β exposure in multiple sclerosisM P Amato
Department of Neurology, University of Florence, Florence, Italy
Neurology 75:1794-802. 2010..To assess pregnancy and fetal outcomes after in utero exposure to interferon-β (IFNβ) in all pregnancies occurring in women with multiple sclerosis (MS) during the study period, with a specific focus on the risk of spontaneous abortion... - Neocortical volume decrease in relapsing-remitting MS patients with mild cognitive impairmentM P Amato
Department of Neurology, University of Florence, Viale Morgagni, 85 50134 Florence, Italy
Neurology 63:89-93. 2004..To assess neocortical changes and their relevance to cognitive impairment in early relapsing-remitting (RR) multiple sclerosis (MS)... - Is there a future for donepezil therapy in the treatment of multiple sclerosis-related cognitive impairment?Maria Pia Amato
Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
Expert Rev Neurother 11:1243-6. 2011..However, a larger multicentric trial failed to confirm any efficacy of donepezil on memory impairment in MS subjects. Possible implications of these findings are discussed in this article... - Management options in multiple sclerosis-associated fatigueMaria Pia Amato
University of Florence, Department of Neurology, Viale Morgagni 85, 50134 Florence, Italy
Expert Opin Pharmacother 13:207-16. 2012..Future research should also address a better understanding of the physiopathologic mechanisms of fatigue and the development and validation of objective assessment tools to be used together with patient self-ratings... - Pharmacoeconomic considerations of multiple sclerosis therapy with the new disease-modifying agentsMaria Pia Amato
Department of Neurology, University of Florence, Viale Morgagni, 85 50134 Florence, Italy
Expert Opin Pharmacother 5:2115-26. 2004..Gathering this kind of information is of critical importance in order to improve the precision of cost-effectiveness estimates in the future... - Clinical management of cognitive impairment in multiple sclerosis: a review of current evidenceM P Amato
Dipartimento di Scienze, Neurologie e Psichiatriche, Universita di Firenze, USL 10 D, Vioale Morgagni 85, 50134 Florence, Italy
Int MS J 10:72-83. 2003.... - Are there protective treatments for cognitive decline in MS?Maria Pia Amato
Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
J Neurol Sci 245:183-6. 2006..As for non-pharmacological interventions based on cognitive rehabilitation, few studies have used an experimental approach and, in general, results have been disappointingly negative. Further research is clearly needed in this area... - Benign multiple sclerosis: cognitive, psychological and social aspects in a clinical cohortMaria Pia Amato
Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
J Neurol 253:1054-9. 2006..Clinical correlates of cognitive impairment were determined by multiple logistic regression analysis... - European validation of a standardized clinical description of multiple sclerosisMaria Pia Amato
Department of Neurological Sciences, University of Florence, Viale Morgagni, 85, 50134, Florence, Italy
J Neurol 251:1472-80. 2004.... - APOE-epsilon4 is not associated with cognitive impairment in relapsing-remitting multiple sclerosisEmilio Portaccio
Department of Neurology, University of Florence, Florence, Italy
Mult Scler 15:1489-94. 2009..006). In conclusion, in our sample CI was associated with higher subcortical damage and cortical atrophy but not with APOE-epsilon4 genotype. The role of APOE-epsilon4 as a possible biomarker in multiple sclerosis is still questionable... - Impact of cognitive impairment on coping strategies in multiple sclerosisBenedetta Goretti
Department of Neurology, University of Florence, Italy
Clin Neurol Neurosurg 112:127-30. 2010..To assess the impact of cognitive impairment (CI) on coping strategies in multiple sclerosis (MS)... - Cognitive impairment predicts conversion to multiple sclerosis in clinically isolated syndromesValentina Zipoli
Department of Neurology, University of Florence, Florence, Italy
Mult Scler 16:62-7. 2010..In these subjects cognitive impairment has a prognostic value in predicting conversion to multiple sclerosis and may therefore play a role in therapeutic decision making... - Improving compliance with interferon-beta therapy in patients with multiple sclerosisEmilio Portaccio
Department of Neurology, University of Florence, Florence, Italy
CNS Drugs 23:453-62. 2009..Further studies assessing its usefulness as an alternative therapy for patients who are intolerant of other IFNbeta formulations are required... - Neocortical volume decrease in relapsing-remitting multiple sclerosis with mild cognitive impairmentEmilio Portaccio
Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
J Neurol Sci 245:195-9. 2006..Grey matter pathology may contribute to the development of cognitive impairment in MS from the earliest stages of the disease... - Intravenous mitoxantrone and cyclophosphamide as second-line therapy in multiple sclerosis: an open-label comparative study of efficacy and safetyValentina Zipoli
Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
J Neurol Sci 266:25-30. 2008..10). Discontinuation due to side effects was more frequent in CTX patients. However, the overall tolerability profile was acceptable in both groups... - Coping strategies, psychological variables and their relationship with quality of life in multiple sclerosisBenedetta Goretti
Department of Neurology, University of Florence, Viale Morgagni, 85, 50134 Florence, Italy
Neurol Sci 30:15-20. 2009..These data point out the importance of a comprehensive assessment of MS patients. Orienting therapeutic interventions, to oppose depression and anxiety and to favour more appropriate coping strategies can improve the patients' QoL... - Motor evoked potentials in multiple sclerosis patients without walking limitation: amplitude vs. conduction time abnormalitiesAndrea Gagliardo
Clinical Neurophysiology Unit, Department of Neurological and Psychiatric Sciences, Careggi Hospital, University of Florence, Viale Morgagni 85, 50100 Florence, Italy
J Neurol 254:220-7. 2007.... - Prevalence of neuromyelitis optica spectrum disorder and phenotype distributionElisa Bizzoco
Department of Neurological and Psychiatric Sciences, Careggi Hospital, Florence, Italy
J Neurol 256:1891-8. 2009..Moreover, this study demonstrates an unexpectedly high prevalence of limited and atypical variants of this disease, not previously documented... - Donepezil for memory impairment in multiple sclerosisMaria Pia Amato
Department of Neurology, University of Florence, Italy
Lancet Neurol 4:72-3. 2005 - Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: implication for assessment of disease activity and treatmentBenedetta Mazzanti
Department of Neurological Sciences, University of Florence, Viale Pieraccini, 6, 50134 Florence, Italy
J Neuroimmunol 199:142-50. 2008.... - Absence of cerebrospinal fluid oligoclonal bands is associated with delayed disability progression in relapsing-remitting MS patients treated with interferon-betaPasquale Annunziata
Department of Neurological Sciences and Behaviour, University of Siena, Italy
J Neurol Sci 244:97-102. 2006..04). The absence of OB and low number of baseline T2-weighted lesions in this cohort of MS patients are favourable prognostic factors influencing the clinical response to IFN-beta treatment in RRMS patients... - Changes in neuropsychological test performance over the workday in multiple sclerosisWilliam W Beatty
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
Clin Neuropsychol 17:551-60. 2003..Furthermore, laboratory studies that report "objective" cognitive fatigue in MS may utilize conditions that model the cognitive fatigue associated with the jobs patients actually perform rather poorly... - Influence of apolipoprotein E epsilon4 genotype on brain tissue integrity in relapsing-remitting multiple sclerosisNicola De Stefano
Department of Neurological and Behavioral Sciences, University of Siena, Siena, Italy
Arch Neurol 61:536-40. 2004..This seems to be related to more extensive tissue destruction and less efficient neuronal maintenance and repair in ApoE epsilon4 carriers... - New natural history of interferon-beta-treated relapsing multiple sclerosisMaria Trojano
Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
Ann Neurol 61:300-6. 2007..To investigate the impact of interferon-beta (IFNbeta) on disease progression in relapsing-remitting multiple sclerosis patients... - Brain damage as detected by magnetization transfer imaging is less pronounced in benign than in early relapsing multiple sclerosisNicola De Stefano
Neurology and Neurometabolic Unit, Department of Neurological and Behavioral Sciences, University of Siena, Italy
Brain 129:2008-16. 2006..This can be due to an extraordinary beneficial response to demyelination of benign patients and may represent the evidence that benign multiple sclerosis truly exists and might be differentiated from other forms of this illness... - Longitudinal follow-up of "benign" multiple sclerosis at 20 yearsMaria Pia Amato
Neurology 69:938; author reply 938-9. 2007 - Clinical correlations of CSF single IgG bandsDiego Franciotta
J Neurol 252:1274-5. 2005