Maria P Amato

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi request reprint The costs of multiple sclerosis: a cross-sectional, multicenter cost-of-illness study in Italy
    Maria Pia Amato
    Department of Neurological Sciences, University of Florence, Italy
    J Neurol 249:152-63. 2002
  2. ncbi request reprint The Rao's Brief Repeatable Battery and Stroop Test: normative values with age, education and gender corrections in an Italian population
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni, 85 50134 Florence, Italy
    Mult Scler 12:787-93. 2006
  3. ncbi request reprint Clinical outcome measures in multiple sclerosis
    Maria Pia Amato
    Department of Neurology, University of Florence, Florence, Italy
    J Neurol Sci 259:118-22. 2007
  4. ncbi request reprint Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni, 85, Florence, Italy 50134
    Arch Neurol 58:1602-6. 2001
  5. ncbi request reprint Multiple sclerosis-related cognitive changes: a review of cross-sectional and longitudinal studies
    Maria Pia Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    J Neurol Sci 245:41-6. 2006
  6. ncbi request reprint Paternal therapy with disease modifying drugs in multiple sclerosis and pregnancy outcomes: a prospective observational multicentric study
    Chiara Pecori
    Department of NEUROFARBA, Section Neurosciences, University of Florence, Largo Brambilla 3, 50134 Florence, Italy
    BMC Neurol 14:114. 2014
  7. pmc Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis
    Francesco Lolli
    Dipartimento di Scienze Biomediche, Sperimentali e Cliniche and Neurofarba, Università of Firenze, Azienda Ospedaliera di Careggi, Largo Brambilla 6, 50134 Firenze, Italy
    J Neuroinflammation 10:94. 2013
  8. pmc Brief International Cognitive Assessment for MS (BICAMS): international standards for validation
    Ralph H B Benedict
    Buffalo General Medical Center, Department of Neurology, Suite E2, 100 High Street, Buffalo, NY 14203, USA
    BMC Neurol 12:55. 2012
  9. doi request reprint Cognitive reserve and cortical atrophy in multiple sclerosis: a longitudinal study
    Maria Pia Amato
    Department of Neurology, University of Florence, Italy
    Neurology 80:1728-33. 2013
  10. doi request reprint Treatment of cognitive impairment in multiple sclerosis: position paper
    Maria Pia Amato
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    J Neurol 260:1452-68. 2013

Collaborators

Detail Information

Publications50

  1. ncbi request reprint The costs of multiple sclerosis: a cross-sectional, multicenter cost-of-illness study in Italy
    Maria Pia Amato
    Department of Neurological Sciences, University of Florence, Italy
    J Neurol 249:152-63. 2002
    ..To estimate the socio-economic impact of multiple sclerosis (MS) in Italy...
  2. ncbi request reprint The Rao's Brief Repeatable Battery and Stroop Test: normative values with age, education and gender corrections in an Italian population
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni, 85 50134 Florence, Italy
    Mult Scler 12:787-93. 2006
    ..Increasing age was associated with worse performance on the ST in version A, and on the SRT-LTS, SRT-CLTR and WLG in version B. Our data can improve the applicability of the BRB for both clinical and research purposes...
  3. ncbi request reprint Clinical outcome measures in multiple sclerosis
    Maria Pia Amato
    Department of Neurology, University of Florence, Florence, Italy
    J Neurol Sci 259:118-22. 2007
    ..To date, no single measure has emerged as the ideal outcome measure: the main advantages and disadvantages of currently available measurement tools are discussed...
  4. ncbi request reprint Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni, 85, Florence, Italy 50134
    Arch Neurol 58:1602-6. 2001
    ..To reassess, in a cohort of patients with early-onset multiple sclerosis, the long-term evolution of cognitive deficits, their relationship to the disease's clinical progression, and their effects on daily life...
  5. ncbi request reprint Multiple sclerosis-related cognitive changes: a review of cross-sectional and longitudinal studies
    Maria Pia Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    J Neurol Sci 245:41-6. 2006
    ..The aim of this paper is to provide a review of existing cross-sectional and longitudinal studies on cognitive deterioration in MS...
  6. ncbi request reprint Paternal therapy with disease modifying drugs in multiple sclerosis and pregnancy outcomes: a prospective observational multicentric study
    Chiara Pecori
    Department of NEUROFARBA, Section Neurosciences, University of Florence, Largo Brambilla 3, 50134 Florence, Italy
    BMC Neurol 14:114. 2014
    ..Most of Multiple Sclerosis (MS) patients undergo disease modifying drug (DMD) therapy at childbearing age. The objective of this prospective, collaborative study, was to assess outcomes of pregnancies fathered by MS patients undergoing DMD...
  7. pmc Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis
    Francesco Lolli
    Dipartimento di Scienze Biomediche, Sperimentali e Cliniche and Neurofarba, Università of Firenze, Azienda Ospedaliera di Careggi, Largo Brambilla 6, 50134 Firenze, Italy
    J Neuroinflammation 10:94. 2013
    ..Here, we evaluated the hypothesis that CD8+ T cell responses to caspase-cleaved antigens derived from effector T cells undergoing apoptosis, may contribute to multiple sclerosis (MS) immunopathology...
  8. pmc Brief International Cognitive Assessment for MS (BICAMS): international standards for validation
    Ralph H B Benedict
    Buffalo General Medical Center, Department of Neurology, Suite E2, 100 High Street, Buffalo, NY 14203, USA
    BMC Neurol 12:55. 2012
    ..At this time, preliminary studies are underway in a number of countries as we move forward with this international assessment tool for cognition in MS...
  9. doi request reprint Cognitive reserve and cortical atrophy in multiple sclerosis: a longitudinal study
    Maria Pia Amato
    Department of Neurology, University of Florence, Italy
    Neurology 80:1728-33. 2013
    ..To test the cognitive reserve (CR) hypothesis in the model of multiple sclerosis (MS) by assessing the interactions among CR, brain atrophy, and cognitive efficiency in patients with relapsing-remitting MS...
  10. doi request reprint Treatment of cognitive impairment in multiple sclerosis: position paper
    Maria Pia Amato
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    J Neurol 260:1452-68. 2013
    ..The treatment and prevention of cognitive impairment needs to remain a key research focus, identifying new interventions and improving clinical trial methodology...
  11. pmc Epidural analgesia and cesarean delivery in multiple sclerosis post-partum relapses: the Italian cohort study
    Luisa Pastò
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    BMC Neurol 12:165. 2012
    ..The objective of this study was to assess the impact of epidural analgesia (EA) and caesarean delivery (CD) on the risk of post-partum relapses and disability in women with MS...
  12. pmc Pregnancy and fetal outcomes after Glatiramer Acetate exposure in patients with multiple sclerosis: a prospective observational multicentric study
    Marta Giannini
    Department of Neurology, University of Florence, Florence, Italy
    BMC Neurol 12:124. 2012
    ....
  13. doi request reprint Association of MRI metrics and cognitive impairment in radiologically isolated syndromes
    M P Amato
    Department of Neurology, University of Florence, Florence, Italy
    Neurology 78:309-14. 2012
    ....
  14. pmc Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients
    Valentina Durastanti
    Department of Neurological Sciences, University La Sapienza, Viale dell Universita, 30, 00185, Rome, Italy
    J Transl Med 9:42. 2011
    ..The aim of the study was to investigate the dynamic profile of neopterin and kyn/trp ratio in patients with relapsing remitting multiple sclerosis (RRMS) treated with two different doses of IFNβ-1a over a period of 24 months...
  15. pmc Changes in magnetic resonance imaging disease measures over 3 years in mildly disabled patients with relapsing-remitting multiple sclerosis receiving interferon β-1a in the COGnitive Impairment in MUltiple Sclerosis (COGIMUS) study
    Stefano Bastianello
    National Neurological Institute, C Mondino Foundation, Pavia, Italy
    BMC Neurol 11:125. 2011
    ..In clinical trials, MRI has been found to detect treatment effects with greater sensitivity than clinical measures; however, clinical and MRI outcomes tend to correlate poorly...
  16. doi request reprint Cognitive assessment and quantitative magnetic resonance metrics can help to identify benign multiple sclerosis
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Neurology 71:632-8. 2008
    ..Moreover, no paraclinical markers are currently available to reliably identify patients who will remain benign in the long term...
  17. ncbi request reprint Pharmacoeconomic considerations of multiple sclerosis therapy with the new disease-modifying agents
    Maria Pia Amato
    Department of Neurology, University of Florence, Viale Morgagni, 85 50134 Florence, Italy
    Expert Opin Pharmacother 5:2115-26. 2004
    ..Gathering this kind of information is of critical importance in order to improve the precision of cost-effectiveness estimates in the future...
  18. doi request reprint Cognitive and psychosocial features of childhood and juvenile MS
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Neurology 70:1891-7. 2008
    ..To assess the impact of multiple sclerosis (MS) on cognitive and psychosocial functioning in childhood and juvenile cases...
  19. doi request reprint Pregnancy and fetal outcomes after interferon-β exposure in multiple sclerosis
    M P Amato
    Department of Neurology, University of Florence, Florence, Italy
    Neurology 75:1794-802. 2010
    ..To assess pregnancy and fetal outcomes after in utero exposure to interferon-β (IFNβ) in all pregnancies occurring in women with multiple sclerosis (MS) during the study period, with a specific focus on the risk of spontaneous abortion...
  20. doi request reprint Cognitive changes in multiple sclerosis
    Maria Pia Amato
    Department of Neurology, University of Florence, Viale Morgagni, 85 50134 Florence, Italy
    Expert Rev Neurother 8:1585-96. 2008
    ..In this article, we review the current knowledge on CD in MS and highlight areas of special importance for future research in the field...
  21. doi request reprint Cognitive impairment in early stages of multiple sclerosis
    Maria Pia Amato
    Department of Neurology, University of Florence, Florence, Italy
    Neurol Sci 31:S211-4. 2010
    ..Early treatment with disease-modifying drugs that can contain the disease burden in the brain seems to be highly advisable in order to prevent or delay the development of cognitive impairment...
  22. doi request reprint Relevance of cognitive deterioration in early relapsing-remitting MS: a 3-year follow-up study
    Maria P Amato
    Department of Neurology, University of Florence, Italy
    Mult Scler 16:1474-82. 2010
    ..To assess longitudinally cognitive functioning in relapsing-remitting multiple sclerosis (RRMS) patients and its relationship with clinical and MRI variables...
  23. doi request reprint Cognitive and psychosocial features in childhood and juvenile MS: two-year follow-up
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, Florence, Italy
    Neurology 75:1134-40. 2010
    ..To assess the evolution of cognitive and psychosocial functioning in a cohort of childhood and juvenile multiple sclerosis (MS) cases after a mean period of 2 years had elapsed since baseline evaluation...
  24. ncbi request reprint Is there a future for donepezil therapy in the treatment of multiple sclerosis-related cognitive impairment?
    Maria Pia Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Expert Rev Neurother 11:1243-6. 2011
    ..However, a larger multicentric trial failed to confirm any efficacy of donepezil on memory impairment in MS subjects. Possible implications of these findings are discussed in this article...
  25. doi request reprint Management options in multiple sclerosis-associated fatigue
    Maria Pia Amato
    University of Florence, Department of Neurology, Viale Morgagni 85, 50134 Florence, Italy
    Expert Opin Pharmacother 13:207-16. 2012
    ..Yet, due to limitations of available evidence, current therapeutic approaches for treating fatigue are based mainly on preliminary studies and expert consensus...
  26. ncbi request reprint Association of neocortical volume changes with cognitive deterioration in relapsing-remitting multiple sclerosis
    Maria Pia Amato
    Department of Neurology, University of Florence, Viale Morgagni, 85 50134 Florence, Italy
    Arch Neurol 64:1157-61. 2007
    ....
  27. ncbi request reprint Clinical management of cognitive impairment in multiple sclerosis: a review of current evidence
    M P Amato
    Dipartimento di Scienze, Neurologie e Psichiatriche, Universita di Firenze, USL 10 D, Vioale Morgagni 85, 50134 Florence, Italy
    Int MS J 10:72-83. 2003
    ....
  28. ncbi request reprint Neocortical volume decrease in relapsing-remitting MS patients with mild cognitive impairment
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni, 85 50134 Florence, Italy
    Neurology 63:89-93. 2004
    ..To assess neocortical changes and their relevance to cognitive impairment in early relapsing-remitting (RR) multiple sclerosis (MS)...
  29. ncbi request reprint European validation of a standardized clinical description of multiple sclerosis
    Maria Pia Amato
    Department of Neurological Sciences, University of Florence, Viale Morgagni, 85, 50134, Florence, Italy
    J Neurol 251:1472-80. 2004
    ....
  30. ncbi request reprint Benign multiple sclerosis: cognitive, psychological and social aspects in a clinical cohort
    Maria Pia Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    J Neurol 253:1054-9. 2006
    ..Clinical correlates of cognitive impairment were determined by multiple logistic regression analysis...
  31. ncbi request reprint Are there protective treatments for cognitive decline in MS?
    Maria Pia Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    J Neurol Sci 245:183-6. 2006
    ..As for non-pharmacological interventions based on cognitive rehabilitation, few studies have used an experimental approach and, in general, results have been disappointingly negative. Further research is clearly needed in this area...
  32. doi request reprint APOE-epsilon4 is not associated with cognitive impairment in relapsing-remitting multiple sclerosis
    Emilio Portaccio
    Department of Neurology, University of Florence, Florence, Italy
    Mult Scler 15:1489-94. 2009
    ..006). In conclusion, in our sample CI was associated with higher subcortical damage and cortical atrophy but not with APOE-epsilon4 genotype. The role of APOE-epsilon4 as a possible biomarker in multiple sclerosis is still questionable...
  33. doi request reprint Impact of cognitive impairment on coping strategies in multiple sclerosis
    Benedetta Goretti
    Department of Neurology, University of Florence, Italy
    Clin Neurol Neurosurg 112:127-30. 2010
    ..To assess the impact of cognitive impairment (CI) on coping strategies in multiple sclerosis (MS)...
  34. doi request reprint Cognitive impairment predicts conversion to multiple sclerosis in clinically isolated syndromes
    Valentina Zipoli
    Department of Neurology, University of Florence, Florence, Italy
    Mult Scler 16:62-7. 2010
    ..In these subjects cognitive impairment has a prognostic value in predicting conversion to multiple sclerosis and may therefore play a role in therapeutic decision making...
  35. ncbi request reprint Neocortical volume decrease in relapsing-remitting multiple sclerosis with mild cognitive impairment
    Emilio Portaccio
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    J Neurol Sci 245:195-9. 2006
    ..Grey matter pathology may contribute to the development of cognitive impairment in MS from the earliest stages of the disease...
  36. ncbi request reprint Intravenous mitoxantrone and cyclophosphamide as second-line therapy in multiple sclerosis: an open-label comparative study of efficacy and safety
    Valentina Zipoli
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    J Neurol Sci 266:25-30. 2008
    ..10). Discontinuation due to side effects was more frequent in CTX patients. However, the overall tolerability profile was acceptable in both groups...
  37. doi request reprint Improving compliance with interferon-beta therapy in patients with multiple sclerosis
    Emilio Portaccio
    Department of Neurology, University of Florence, Florence, Italy
    CNS Drugs 23:453-62. 2009
    ..Further studies assessing its usefulness as an alternative therapy for patients who are intolerant of other IFNbeta formulations are required...
  38. doi request reprint Coping strategies, psychological variables and their relationship with quality of life in multiple sclerosis
    Benedetta Goretti
    Department of Neurology, University of Florence, Viale Morgagni, 85, 50134 Florence, Italy
    Neurol Sci 30:15-20. 2009
    ..These data point out the importance of a comprehensive assessment of MS patients. Orienting therapeutic interventions, to oppose depression and anxiety and to favour more appropriate coping strategies can improve the patients' QoL...
  39. ncbi request reprint Motor evoked potentials in multiple sclerosis patients without walking limitation: amplitude vs. conduction time abnormalities
    Andrea Gagliardo
    Clinical Neurophysiology Unit, Department of Neurological and Psychiatric Sciences, Careggi Hospital, University of Florence, Viale Morgagni 85, 50100 Florence, Italy
    J Neurol 254:220-7. 2007
    ....
  40. doi request reprint Prevalence of neuromyelitis optica spectrum disorder and phenotype distribution
    Elisa Bizzoco
    Department of Neurological and Psychiatric Sciences, Careggi Hospital, Florence, Italy
    J Neurol 256:1891-8. 2009
    ..Moreover, this study demonstrates an unexpectedly high prevalence of limited and atypical variants of this disease, not previously documented...
  41. ncbi request reprint Donepezil for memory impairment in multiple sclerosis
    Maria Pia Amato
    Department of Neurology, University of Florence, Italy
    Lancet Neurol 4:72-3. 2005
  42. doi request reprint Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: implication for assessment of disease activity and treatment
    Benedetta Mazzanti
    Department of Neurological Sciences, University of Florence, Viale Pieraccini, 6, 50134 Florence, Italy
    J Neuroimmunol 199:142-50. 2008
    ....
  43. ncbi request reprint Changes in neuropsychological test performance over the workday in multiple sclerosis
    William W Beatty
    Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Clin Neuropsychol 17:551-60. 2003
    ..Furthermore, laboratory studies that report "objective" cognitive fatigue in MS may utilize conditions that model the cognitive fatigue associated with the jobs patients actually perform rather poorly...
  44. ncbi request reprint Influence of apolipoprotein E epsilon4 genotype on brain tissue integrity in relapsing-remitting multiple sclerosis
    Nicola De Stefano
    Department of Neurological and Behavioral Sciences, University of Siena, Siena, Italy
    Arch Neurol 61:536-40. 2004
    ..This seems to be related to more extensive tissue destruction and less efficient neuronal maintenance and repair in ApoE epsilon4 carriers...
  45. ncbi request reprint Longitudinal follow-up of "benign" multiple sclerosis at 20 years
    Maria Pia Amato
    Neurology 69:938; author reply 938-9. 2007
  46. ncbi request reprint Absence of cerebrospinal fluid oligoclonal bands is associated with delayed disability progression in relapsing-remitting MS patients treated with interferon-beta
    Pasquale Annunziata
    Department of Neurological Sciences and Behaviour, University of Siena, Italy
    J Neurol Sci 244:97-102. 2006
    ..04). The absence of OB and low number of baseline T2-weighted lesions in this cohort of MS patients are favourable prognostic factors influencing the clinical response to IFN-beta treatment in RRMS patients...
  47. pmc Early prediction of the long term evolution of multiple sclerosis: the Bayesian Risk Estimate for Multiple Sclerosis (BREMS) score
    Roberto Bergamaschi
    Multiple Sclerosis Centre, Department of Clinical Neurology, Neurological Institute C Mondino, Via Mondino 2, 27100 Pavia, Italy
    J Neurol Neurosurg Psychiatry 78:757-9. 2007
    ..To propose a simple tool for early prediction of unfavourable long term evolution of multiple sclerosis (MS)...
  48. ncbi request reprint Brain damage as detected by magnetization transfer imaging is less pronounced in benign than in early relapsing multiple sclerosis
    Nicola De Stefano
    Neurology and Neurometabolic Unit, Department of Neurological and Behavioral Sciences, University of Siena, Italy
    Brain 129:2008-16. 2006
    ..This can be due to an extraordinary beneficial response to demyelination of benign patients and may represent the evidence that benign multiple sclerosis truly exists and might be differentiated from other forms of this illness...
  49. ncbi request reprint New natural history of interferon-beta-treated relapsing multiple sclerosis
    Maria Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Ann Neurol 61:300-6. 2007
    ..To investigate the impact of interferon-beta (IFNbeta) on disease progression in relapsing-remitting multiple sclerosis patients...
  50. ncbi request reprint Clinical correlations of CSF single IgG bands
    Diego Franciotta
    J Neurol 252:1274-5. 2005