Research Topics
Species | D AlvaroSummaryAffiliation: University of Rome La Sapienza Country: Italy Publications
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Detail Information
Publications
Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoformsSilvia Taffetani
Department of Gastroenterology, Universita Politecnica delle Marche, Nuovo Polo Didattico, III piano, Ancona, Italy
BMC Physiol 7:6. 2007..We propose to evaluate the role and mechanisms of action by which prolactin regulates the growth of female cholangiocytes...
Corticosteroids modulate the secretory processes of the rat intrahepatic biliary epitheliumDomenico Alvaro
Division of Gastroenterology, Department of Clinical Medicine, University La Sapienza, Rome, Italy
Gastroenterology 122:1058-69. 2002..We investigated the expression of glucocorticoid receptors (GcRs) in the intrahepatic biliary epithelium and the role of corticosteroids in the regulation of cholangiocyte secretion...- Estrogens and the pathophysiology of the biliary treeDomenico Alvaro
Division of Gastroenterology, University of Rome, La Sapienza, via R Rossellini 51, 00137 Rome, Italy
World J Gastroenterol 12:3537-45. 2006..This review specifically deals with the recent advances related to the role and mechanisms by which estrogens modulate cholangiocyte functions in normal and pathological conditions... - Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liverDomenico Alvaro
Division of Gastroenterology, Department of Clinical Medicine, University La Sapienza, via R Rossellini 51, 00137 Rome, Italy
Gastroenterology 132:415-31. 2007..The purpose of this review is to summarize the recent findings on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangiocyte biology... - Serum and biliary insulin-like growth factor I and vascular endothelial growth factor in determining the cause of obstructive cholestasisDomenico Alvaro
Division of Gastroenterology, Department of Clinical Medicine, University of Rome Sapienza, Rome, Italy
Ann Intern Med 147:451-9. 2007..Cholangiocarcinoma cells express and secrete insulin-like growth factor I (IGF-I) and vascular endothelial growth factor (VEGF)... - The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axisDomenico Alvaro
Division of Gastroenterology, University of Rome, La Sapienza, Rome, Italy
J Hepatol 43:875-83. 2005..We evaluated the role and mechanisms by which the GH/IGF1 axis modulates cholangiocyte proliferation... - Serum and bile biomarkers for cholangiocarcinomaDomenico Alvaro
Division of Gastroenterology, Department of Clinical Medicine, Polo Pontino, University of Rome La Sapienza, Rome, Italy
Curr Opin Gastroenterol 25:279-84. 2009.... - Acute cholestatic hepatitis induced by bupropion prescribed as pharmacological support to stop smoking. A case reportD Alvaro
Department of Clinical Medicine, University of Rome La Sapienza, Italy
Dig Liver Dis 33:703-6. 2001..Other causes of liver damage were excluded. Considering the clinical diagnostic scale for hepatotoxic adverse drug reaction, our patient showed a score compatible with the final diagnosis of bupropion-related cholestatic hepatitis... 
Descriptive epidemiology of cholangiocarcinoma in ItalyDomenico Alvaro
Department of Clinical Medicine, Division of Gastroenterology, Polo Pontino, Sapienza University of Rome, Rome, Italy
Dig Liver Dis 42:490-5. 2010..Very little data exist on the epidemiology of cholangiocarcinoma in Italy...- Cholangiocarcinoma in Italy: A national survey on clinical characteristics, diagnostic modalities and treatment. Results from the "Cholangiocarcinoma" committee of the Italian Association for the Study of Liver diseaseDomenico Alvaro
Department of Clinical Medicine, Sapienza University of Rome, Italy
Dig Liver Dis 43:60-5. 2011..Very few studies assessed cholangiocarcinoma clinical characteristics... - Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functionsD Alvaro
Division of Gastroenterology, Department of Clinical Medicine, University of Rome, La Sapienza, Viale dell Universita 37, 00185 Rome, Italy
J Clin Invest 100:1349-62. 1997.... - Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factorA Mancino
Department of Clinical Medicine, Division of Gastroenterology, University of Rome, La Sapienza, Rome, Italy
Dig Liver Dis 41:156-63. 2009..Estrogens may induce the proliferation of neoplastic cells by activating neo-angiogenesis... - The function of alkaline phosphatase in the liver: regulation of intrahepatic biliary epithelium secretory activities in the ratD Alvaro
Division of Gastroenterology, Department of Clinical Medicine, University of Rome, La Sapienza, Rome, Italy
Hepatology 32:174-84. 2000..These findings indicate that AP plays an active role in down-regulating the secretory activities of the intrahepatic biliary epithelium... - Selective hepatic enrichment of polyunsaturated phosphatidylcholines after intravenous administration of dimethylethanolamine in the ratD Alvaro
II Department of Gastroenterology, University of Rome La Sapienza, Italy
Biochim Biophys Acta 1006:116-20. 1989..The selective hepatic enrichment with polyunsaturated PC species after DME infusion may offer a new experimental tool for studying hepatic membrane metabolism... - Bile salts regulate proliferation and apoptosis of liver cells by modulating the IGF1 systemV Drudi Metalli
Division of Gastroenterology, Department of Clinical Medicine, University of Rome, La Sapienza, Rome, Italy
Dig Liver Dis 39:654-62. 2007..In different cell types, the insulin-like growth factor 1 and its receptor modulate growth, apoptosis and damage repair in cooperation with estrogen receptors... - Improvement of estradiol 17 beta-D-glucuronide cholestasis by intravenous administration of dimethylethanolamine in the ratD Alvaro
II Cattedra di Gastroenterologia, University of Rome La Sapienza, Italy
Hepatology 13:1158-72. 1991..Dilatation of canaliculi and loss of microvilli were evident in estradiol 17 beta-D-glucuronide controls 180 min after estradiol 17 beta-D-glucuronide administration.(ABSTRACT TRUNCATED AT 400 WORDS).. - Hormonal regulation of bicarbonate secretion in the biliary epitheliumD Alvaro
Department of Clinical Medicine, University of Rome La Sapienza, Italy
Yale J Biol Med 70:417-26. 1997..Somatostatin and gastrin inhibit basal and/or secretin-stimulated bicarbonate excretion by down-regulating the secretin receptor and decreasing cAMP intracellular levels induced by secretin... - New insights into liver stem cellsE Gaudio
Department of Human Anatomy, Sapienza University of Rome, Rome, Italy
Dig Liver Dis 41:455-62. 2009..The possibility of applying stem cell therapy to liver diseases will represent a major goal in this field... - Morphological and functional features of hepatic cyst epithelium in autosomal dominant polycystic kidney diseaseDomenico Alvaro
Department of Clinical Medicine, University of Rome Sapienza, via R Rossellini 51, 00137 Rome, Italy
Am J Pathol 172:321-32. 2008..Our findings could explain the role of estrogens in accelerating the progression of ADPKD and may suggest a potential benefit of therapeutic strategies based on estrogen antagonism... - Insulin-like growth factor-1 isoforms in rat hepatocytes and cholangiocytes and their involvement in protection against cholestatic injuryManuela Gatto
Department of Clinical Medicine, Division of Gastroenterology, University of Rome La Sapienza, Rome, Italy
Lab Invest 88:986-94. 2008..These findings indicate that, besides muscle and neural tissues, also in liver cells the 'locally acting' IGF1 isoform is important in modulating response to damage... - Hepatic microcirculation and cholangiocyte physiopathologyE Gaudio
Department of Anatomy, University of Rome La Sapienza, Rome, Italy
Ital J Anat Embryol 110:71-5. 2005..Taking in consideration the wide extension of PBP during BDL, aim of our study is to investigate the role of VEGF in stimulating angiogenesis and also in the modulation of epithelial cells proliferation... - New insights on the molecular and cell biology of human cholangiopathiesDomenico Alvaro
Division of Gastroenterology, Department of Clinical Medicine, Rome, Italy
Mol Aspects Med 29:50-7. 2008..Recent advances on the molecular and cell biology of human cholangiopathies are opening new potential therapeutic perspectives for these diseases... - Cholangiocytes and blood supplyEugenio Gaudio
Department of Human Anatomy, University of Rome, La Sapienza, Rome, Italy
World J Gastroenterol 12:3546-52. 2006.... - Nerve growth factor modulates the proliferative capacity of the intrahepatic biliary epithelium in experimental cholestasisAlessandro Gigliozzi
Division of Gastroenterology, Department of Clinical Medicine, University of Rome La Sapienza, Italy
Gastroenterology 127:1198-209. 2004..NGF induces cholangiocyte proliferation by activating the ERK and, predominantly, the phosphatidylinositol 3-kinase pathway and exerts an additive effect in combination with estrogens on proliferation... - Biliary epithelium: a new chapter in cell biologyD Alvaro
Department of Clinical Medicine, University of Rome La Sapienza, Italy
Ital J Gastroenterol Hepatol 31:78-83. 1999..The aim of this manuscript is to revise recent knowledge on cell biology of the biliary epithelium... - Cholangiocarcinoma: risk factors and clinical presentationM Gatto
Department of Clinical Medicine, Division of Gastroenterology, Sapienza University of Rome, Polo Pontino, Rome, Italy
Eur Rev Med Pharmacol Sci 14:363-7. 2010..A number of serum and bile biomarkers have been recently proposed for the diagnosis of CCA but, their impact on the early diagnosis is still under the evaluation... - Effect of ovariectomy on the proliferative capacity of intrahepatic rat cholangiocytesDomenico Alvaro
Division of Gastroenterology, University La Sapienza, Rome, Italy
Gastroenterology 123:336-44. 2002..On the basis of these data, the hypothesis of an estrogenic functional deficiency in chronic cholestatic liver diseases should merit careful attention... - Administration of r-VEGF-A prevents hepatic artery ligation-induced bile duct damage in bile duct ligated ratsEugenio Gaudio
Division of Anatomy, University La Sapienza, Rome, Italy
Am J Physiol Gastrointest Liver Physiol 291:G307-17. 2006..The effects of HAL on the PBP and cholangiocyte functions were prevented by r-VEGF-A, which, by maintaining the integrity of the PBP and cholangiocyte proliferation, prevents damage of bile ducts following ischemic injury... - Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinomaDomenico Alvaro
Department of Clinical Medicine, Division of Gastroenterology, University of Rome, via R. Rossellini 51, 00137 Rome, Italy
Am J Pathol 169:877-88. 2006..Modulation of ER and IGF-1R could represent a strategy for the management of cholangiocarcinoma... - Alfa and beta estrogen receptors and the biliary treeDomenico Alvaro
Division of Gastroenterology, Department of Clinical Medicine, University of Rome La Sapienza, Via valsolda 45 i, 00141 Rome, Italy
Mol Cell Endocrinol 193:105-8. 2002..This indicates a major involvement of the ERK system in the estrogen modulation of cholangiocyte proliferation... - Intracellular pathways mediating estrogen-induced cholangiocyte proliferation in the ratDomenico Alvaro
Department of Clinical Medicine, Division of Gastroenterology, University of Rome, La Sapienza, Rome, Italy
Hepatology 36:297-304. 2002..This might suggest that pharmacologic modulation of ER, ERK, and/or Src could be proposed for the treatment of human pathology characterized by dysregulation of cholangiocyte proliferation... - Cholangiocarcinoma: update and future perspectivesManuela Gatto
Department of Clinical Medicine, Division of Gastroenterology, University of Rome Sapienza, Polo Pontino, R Rosselini 51, Rome, Italy
Dig Liver Dis 42:253-60. 2010..This manuscript deals with the most recent advances in the epidemiology, biology and clinical presentation of cholangiocarcinoma... - Polycystins play a key role in the modulation of cholangiocyte proliferationAlessia Torrice
Division of Gastroenterology, University of Rome, Sapienza, Rome, Italy
Dig Liver Dis 42:377-85. 2010..Mutations of PC-1 or PC-2 occur in polycystic liver where cholangiocyte proliferation is enhanced... - Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanismEugenio Gaudio
Division of Anatomy, University La Sapienza, Rome, Italy
Gastroenterology 130:1270-82. 2006..The role of VEGF in cholangiocyte pathophysiology is unknown. We evaluated the role of VEGF in the regulation of cholangiocyte proliferation in rats that underwent bile duct ligation... - Estrogen receptors in cholangiocytes and the progression of primary biliary cirrhosisDomenico Alvaro
Division of Gastroenterology, Department of Clinical Medicine, University of Rome, La Sapienza, via R Rossellini 51, 00137 Rome, Italy
J Hepatol 41:905-12. 2004..Estrogen receptors (ER) in cholangiocytes of primary biliary cirrhosis (PBC) patients and their relationship with cell proliferation and death were evaluated... - Atorvastatin-induced prolonged cholestasis with bile duct damageManuela Merli
Division of Gastroenterology, Department of Clinical Medicine, University of Rome Sapienza, Rome, Italy
Clin Drug Investig 30:205-9. 2010..This is a rare case of cholestasis probably caused by atorvastatin and unusually characterized by bile duct damage... - Taurocholate feeding prevents CCl4-induced damage of large cholangiocytes through PI3-kinase-dependent mechanismLuca Marucci
Department of Gastroenterology, University of Ancona, Italy
Am J Physiol Gastrointest Liver Physiol 284:G290-301. 2003..Taurocholate protects cholangiocytes from CCl(4)-induced apoptosis by a PI3-K-dependent mechanism. Bile acids are important in the prevention of drug-induced ductopenia in cholangiopathies... - Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotoninMarco Marzioni
Department of Medical Physiology, Scott and White Hospital, and Texas A and M University Health System Science Center, 702 Southwest H.K. Dodgen Loop, Temple, TX 76504, USA
Gastroenterology 128:121-37. 2005..Our novel findings might open new approaches for the management of cholangiopathies... - Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMPGene D Lesage
Department of Medicine, Scott and White Hospital, and The Texas A and M University System HSC, COM, Temple, TX 76504, USA
Hepatology 40:1116-27. 2004..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)... - Leptin enhances cholangiocarcinoma cell growthGiammarco Fava
Department of Gastroenterology, Universita Politecnica delle Marche, Ancona, Italy
Cancer Res 68:6752-61. 2008..Modulation of the leptin-mediated signal could be considered a valid tool for the prevention and treatment of cholangiocarcinoma... - gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathwayGiammarco Fava
Central Texas Veterans Health Care System, Research Service, College of Medicine, Temple, 76504, USA
Cancer Res 65:11437-46. 2005..GABA decreases biliary cancer proliferation and reduces the metastatic potential of cholangiocarcinoma. GABA may represent a therapeutic agent for patients affected by malignancies of the biliary tract... - cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathwayHeather Francis
Division of Research and Education, Scott and White Hospital, The Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76504, USA
J Hepatol 41:528-37. 2004..CONCLUSIONS: Modulation of the PKA/Src/MEK/ERK1/2 pathway may be important in the regulation of cholangiocyte growth and secretion observed in cholestatic liver diseases... - Regulation of ERK/JNK/p70S6K in two rat models of liver injury and fibrosisGianluca Svegliati-Baroni
Clinica di Gastroenterologia, Universita di Ancona, Ospedale Regionale Torrette, Via Conca, 60020 Ancona, Italy
J Hepatol 39:528-37. 2003..The regulation of three major intracellular signalling protein kinases was investigated in two models of liver injury leading to hepatic fibrosis, dimethylnitrosamine administration (DMN) and bile duct ligation (BDL)... - Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct-ligated ratsMarco Marzioni
Medical Physiology, Department of Internal Medicine, R and E, Scott and White Hospital, The Texas A and M University System Health Sciences Center, College of Medicine, and Central Texas Veterans Health Care System, Temple, Texas 76504, USA
Am J Physiol Gastrointest Liver Physiol 284:G837-52. 2003..Bile acids are important in modulating cholangiocyte proliferation in denervated livers... - Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated ratsLeonardo Baiocchi
The Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76504, USA
J Hepatol 38:136-47. 2003..Taurohyodeoxycholate-induced hypercholeresis in BDL rats is unrelated to enhanced phospholipid excretion... - [Pathophysiology of cholangiocytes: recent advances]Maria Grazia Mancino
Divisione di Gastroenterologia, Dipartimento di Medicina Clinica, Universita La Sapienza, Roma
Recenti Prog Med 98:583-8. 2007..Recent advances on the molecular and cell biology of cholangiocytes are opening new potential therapeutic perspectives for the human chronic liver diseases... - Increased susceptibility of cholangiocytes to tumor necrosis factor-alpha cytotoxicity after bile duct ligationGianfranco Alpini
Department of Internal Medicine, Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76502, USA
Am J Physiol Cell Physiol 285:C183-94. 2003..Thus TNF-alpha mediates cholangiocyte injury and altered ductal secretion following bile duct ligation. These observations suggest that cholestasis may enhance susceptibility to cytokine-mediated cholangiocyte injury... - Estrogens maintain bile duct mass and reduce apoptosis after biliodigestive anastomosis in bile duct ligated ratsGianluca Svegliati-Baroni
Clinica di Gastroenterologia, Universita Politecnica delle Marche, INRCA, IRCCS, Via Tronto, Ancona, 60020, Italy
J Hepatol 44:1158-66. 2006..We thus evaluated whether estrogen administration protect from the bile duct loss induced by the biliary-digestive diversion in bile duct ligated (BDL) rats... - Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in ratsGianfranco Alpini
Department of Internal Medicine, Scott and White Hospital and The Texas A and M University System Health Science Center College of Medicine, and Central Texas Veterans Health Care System, Temple, Texas, USA
Gastroenterology 123:1226-37. 2002..We tested the hypothesis that during bile duct obstruction, increased biliary bile acids trigger cholangiocyte proliferation and secretion by a phosphatidylinositol 3-kinase (PI3-K)-dependent pathway... - The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated ratsHeather Francis
Central Texas Veterans Health Care System, The Texas A and M University System Health Science Center College of Medicine, Medical Research Bldg, Temple, TX 76504, USA
Am J Physiol Cell Physiol 293:C1252-62. 2007..alpha(2)-Adrenergic receptors play a role in counterregulating enhanced ductal secretion associated with cholangiocyte proliferation in chronic cholestatic liver diseases... - Activation of the IGF1 system characterizes cholangiocyte survival during progression of primary biliary cirrhosisPaolo Onori
Department of Experimental Medicine, University of L Aquila, Italy
J Histochem Cytochem 55:327-34. 2007..This was associated and correlated with a balance of pro- and antiapoptotic proteins favoring survival rather than apoptosis, suggesting a major role of IGF1 system in promoting cholangiocyte survival... - Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liverMarco Marzioni
Department of Gastroenterology, Universita Politecnica delle Marche, Ancona, Italy
Liver Int 27:558-68. 2007..Bile acids and neurotransmitters co-operatively regulate the biological response of the biliary epithelium to cholestasis. Adrenergic denervation of the liver during cholestasis results in the damage of bile ducts... - H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathwayHeather Francis
Department of Research and Education, College of Medicine, Scott and White Hospital and The Texas A and M University System Health Science Center, Temple, TX 76504, USA
Lab Invest 87:473-87. 2007..Downregulation of cAMP-dependent PKA/ERK1/2/Elk-1 phosphorylation (by activation of H3R) is important in the inhibition of cholangiocyte growth in liver diseases... - Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activityShannon Glaser
Department of Internal Medicine, Texas A and M University System Health Sciences Center, College of Medicine, Temple, Texas 76504, USA
Am J Physiol Gastrointest Liver Physiol 284:G683-94. 2003..The dopaminergic nervous system counterregulates secretin-stimulated ductal secretion in experimental cholestasis... - Gastrin reverses established cholangiocyte proliferation and enhanced secretin-stimulated ductal secretion of BDL rats by activation of apoptosis through increased expression of Ca2+- dependent PKC isoformsSharon Glaser
Division of Research and Education, Scott and White Hospital and The Texas A and M University System Health Science Center, College of Medicine, 76504, USA
Liver Int 23:78-88. 2003..SUMMARY/CONCLUSION: Gastrin inhibits cholangiocyte proliferation and secretin-induced ductal secretion in BDL rats by increasing apoptosis through a PKC-mediated mechanism... - Tamoxifen in treatment of primary biliary cirrhosisPietro Invernizzi
Hepatology 39:1175-6. 2004 - Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activityGene D Lesage
Department of Internal Medicine, Scott and White Hospital and The Texas A and M University System HSC COM, Temple, TX, USA
Hepatology 36:641-51. 2002..In conclusion, insulin counter-regulates cholangiocyte secretory processes in the BDL model, which is characterized by cholangiocyte proliferation... - Hepatic "stem" cells: state of the artMaria Grazia Mancino
Department of Human Anatomy, Italy State University La Sapienza of Rome
Ital J Anat Embryol 112:93-109. 2007..The aim of the present review is to update readers with the evolving concepts about hepatic stem cells biology, their characterization and isolation methods and finally their therapeutic potential... - Adrenergic receptor agonists prevent bile duct injury induced by adrenergic denervation by increased cAMP levels and activation of AktShannon Glaser
Division of Research and Education, College of Medicine, Scott and White Hospital and The Texas A and M University System Health Science Center, Temple, 76504, USA
Am J Physiol Gastrointest Liver Physiol 290:G813-26. 2006..In conclusion, we propose that adrenergic innervation plays a role in the regulation of biliary mass and cholangiocyte functions during BDL by modulating intracellular cAMP levels...