D Alvaro

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. pmc Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms
    Silvia Taffetani
    Department of Gastroenterology, Universita Politecnica delle Marche, Nuovo Polo Didattico, III piano, Ancona, Italy
    BMC Physiol 7:6. 2007
  2. ncbi request reprint Corticosteroids modulate the secretory processes of the rat intrahepatic biliary epithelium
    Domenico Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Gastroenterology 122:1058-69. 2002
  3. ncbi request reprint Estrogens and the pathophysiology of the biliary tree
    Domenico Alvaro
    Division of Gastroenterology, University of Rome, La Sapienza, via R Rossellini 51, 00137 Rome, Italy
    World J Gastroenterol 12:3537-45. 2006
  4. ncbi request reprint Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver
    Domenico Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, University La Sapienza, via R Rossellini 51, 00137 Rome, Italy
    Gastroenterology 132:415-31. 2007
  5. ncbi request reprint Serum and biliary insulin-like growth factor I and vascular endothelial growth factor in determining the cause of obstructive cholestasis
    Domenico Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, University of Rome Sapienza, Rome, Italy
    Ann Intern Med 147:451-9. 2007
  6. ncbi request reprint The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis
    Domenico Alvaro
    Division of Gastroenterology, University of Rome, La Sapienza, Rome, Italy
    J Hepatol 43:875-83. 2005
  7. ncbi request reprint Serum and bile biomarkers for cholangiocarcinoma
    Domenico Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, Polo Pontino, University of Rome La Sapienza, Rome, Italy
    Curr Opin Gastroenterol 25:279-84. 2009
  8. ncbi request reprint Acute cholestatic hepatitis induced by bupropion prescribed as pharmacological support to stop smoking. A case report
    D Alvaro
    Department of Clinical Medicine, University of Rome La Sapienza, Italy
    Dig Liver Dis 33:703-6. 2001
  9. doi request reprint Descriptive epidemiology of cholangiocarcinoma in Italy
    Domenico Alvaro
    Department of Clinical Medicine, Division of Gastroenterology, Polo Pontino, Sapienza University of Rome, Rome, Italy
    Dig Liver Dis 42:490-5. 2010
  10. doi request reprint Cholangiocarcinoma in Italy: A national survey on clinical characteristics, diagnostic modalities and treatment. Results from the "Cholangiocarcinoma" committee of the Italian Association for the Study of Liver disease
    Domenico Alvaro
    Department of Clinical Medicine, Sapienza University of Rome, Italy
    Dig Liver Dis 43:60-5. 2011

Collaborators

Detail Information

Publications59

  1. pmc Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms
    Silvia Taffetani
    Department of Gastroenterology, Universita Politecnica delle Marche, Nuovo Polo Didattico, III piano, Ancona, Italy
    BMC Physiol 7:6. 2007
    ..We propose to evaluate the role and mechanisms of action by which prolactin regulates the growth of female cholangiocytes...
  2. ncbi request reprint Corticosteroids modulate the secretory processes of the rat intrahepatic biliary epithelium
    Domenico Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Gastroenterology 122:1058-69. 2002
    ..We investigated the expression of glucocorticoid receptors (GcRs) in the intrahepatic biliary epithelium and the role of corticosteroids in the regulation of cholangiocyte secretion...
  3. ncbi request reprint Estrogens and the pathophysiology of the biliary tree
    Domenico Alvaro
    Division of Gastroenterology, University of Rome, La Sapienza, via R Rossellini 51, 00137 Rome, Italy
    World J Gastroenterol 12:3537-45. 2006
    ..This review specifically deals with the recent advances related to the role and mechanisms by which estrogens modulate cholangiocyte functions in normal and pathological conditions...
  4. ncbi request reprint Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver
    Domenico Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, University La Sapienza, via R Rossellini 51, 00137 Rome, Italy
    Gastroenterology 132:415-31. 2007
    ..The purpose of this review is to summarize the recent findings on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangiocyte biology...
  5. ncbi request reprint Serum and biliary insulin-like growth factor I and vascular endothelial growth factor in determining the cause of obstructive cholestasis
    Domenico Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, University of Rome Sapienza, Rome, Italy
    Ann Intern Med 147:451-9. 2007
    ..Cholangiocarcinoma cells express and secrete insulin-like growth factor I (IGF-I) and vascular endothelial growth factor (VEGF)...
  6. ncbi request reprint The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis
    Domenico Alvaro
    Division of Gastroenterology, University of Rome, La Sapienza, Rome, Italy
    J Hepatol 43:875-83. 2005
    ..We evaluated the role and mechanisms by which the GH/IGF1 axis modulates cholangiocyte proliferation...
  7. ncbi request reprint Serum and bile biomarkers for cholangiocarcinoma
    Domenico Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, Polo Pontino, University of Rome La Sapienza, Rome, Italy
    Curr Opin Gastroenterol 25:279-84. 2009
    ....
  8. ncbi request reprint Acute cholestatic hepatitis induced by bupropion prescribed as pharmacological support to stop smoking. A case report
    D Alvaro
    Department of Clinical Medicine, University of Rome La Sapienza, Italy
    Dig Liver Dis 33:703-6. 2001
    ..Other causes of liver damage were excluded. Considering the clinical diagnostic scale for hepatotoxic adverse drug reaction, our patient showed a score compatible with the final diagnosis of bupropion-related cholestatic hepatitis...
  9. doi request reprint Descriptive epidemiology of cholangiocarcinoma in Italy
    Domenico Alvaro
    Department of Clinical Medicine, Division of Gastroenterology, Polo Pontino, Sapienza University of Rome, Rome, Italy
    Dig Liver Dis 42:490-5. 2010
    ..Very little data exist on the epidemiology of cholangiocarcinoma in Italy...
  10. doi request reprint Cholangiocarcinoma in Italy: A national survey on clinical characteristics, diagnostic modalities and treatment. Results from the "Cholangiocarcinoma" committee of the Italian Association for the Study of Liver disease
    Domenico Alvaro
    Department of Clinical Medicine, Sapienza University of Rome, Italy
    Dig Liver Dis 43:60-5. 2011
    ..Very few studies assessed cholangiocarcinoma clinical characteristics...
  11. pmc Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions
    D Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, University of Rome, La Sapienza, Viale dell Universita 37, 00185 Rome, Italy
    J Clin Invest 100:1349-62. 1997
    ....
  12. pmc Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor
    A Mancino
    Department of Clinical Medicine, Division of Gastroenterology, University of Rome, La Sapienza, Rome, Italy
    Dig Liver Dis 41:156-63. 2009
    ..Estrogens may induce the proliferation of neoplastic cells by activating neo-angiogenesis...
  13. ncbi request reprint The function of alkaline phosphatase in the liver: regulation of intrahepatic biliary epithelium secretory activities in the rat
    D Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, University of Rome, La Sapienza, Rome, Italy
    Hepatology 32:174-84. 2000
    ..These findings indicate that AP plays an active role in down-regulating the secretory activities of the intrahepatic biliary epithelium...
  14. ncbi request reprint Selective hepatic enrichment of polyunsaturated phosphatidylcholines after intravenous administration of dimethylethanolamine in the rat
    D Alvaro
    II Department of Gastroenterology, University of Rome La Sapienza, Italy
    Biochim Biophys Acta 1006:116-20. 1989
    ..The selective hepatic enrichment with polyunsaturated PC species after DME infusion may offer a new experimental tool for studying hepatic membrane metabolism...
  15. ncbi request reprint Bile salts regulate proliferation and apoptosis of liver cells by modulating the IGF1 system
    V Drudi Metalli
    Division of Gastroenterology, Department of Clinical Medicine, University of Rome, La Sapienza, Rome, Italy
    Dig Liver Dis 39:654-62. 2007
    ..In different cell types, the insulin-like growth factor 1 and its receptor modulate growth, apoptosis and damage repair in cooperation with estrogen receptors...
  16. ncbi request reprint Improvement of estradiol 17 beta-D-glucuronide cholestasis by intravenous administration of dimethylethanolamine in the rat
    D Alvaro
    II Cattedra di Gastroenterologia, University of Rome La Sapienza, Italy
    Hepatology 13:1158-72. 1991
    ..Dilatation of canaliculi and loss of microvilli were evident in estradiol 17 beta-D-glucuronide controls 180 min after estradiol 17 beta-D-glucuronide administration.(ABSTRACT TRUNCATED AT 400 WORDS)..
  17. pmc Hormonal regulation of bicarbonate secretion in the biliary epithelium
    D Alvaro
    Department of Clinical Medicine, University of Rome La Sapienza, Italy
    Yale J Biol Med 70:417-26. 1997
    ..Somatostatin and gastrin inhibit basal and/or secretin-stimulated bicarbonate excretion by down-regulating the secretin receptor and decreasing cAMP intracellular levels induced by secretin...
  18. doi request reprint New insights into liver stem cells
    E Gaudio
    Department of Human Anatomy, Sapienza University of Rome, Rome, Italy
    Dig Liver Dis 41:455-62. 2009
    ..The possibility of applying stem cell therapy to liver diseases will represent a major goal in this field...
  19. pmc Morphological and functional features of hepatic cyst epithelium in autosomal dominant polycystic kidney disease
    Domenico Alvaro
    Department of Clinical Medicine, University of Rome Sapienza, via R Rossellini 51, 00137 Rome, Italy
    Am J Pathol 172:321-32. 2008
    ..Our findings could explain the role of estrogens in accelerating the progression of ADPKD and may suggest a potential benefit of therapeutic strategies based on estrogen antagonism...
  20. pmc Insulin-like growth factor-1 isoforms in rat hepatocytes and cholangiocytes and their involvement in protection against cholestatic injury
    Manuela Gatto
    Department of Clinical Medicine, Division of Gastroenterology, University of Rome La Sapienza, Rome, Italy
    Lab Invest 88:986-94. 2008
    ..These findings indicate that, besides muscle and neural tissues, also in liver cells the 'locally acting' IGF1 isoform is important in modulating response to damage...
  21. ncbi request reprint Hepatic microcirculation and cholangiocyte physiopathology
    E Gaudio
    Department of Anatomy, University of Rome La Sapienza, Rome, Italy
    Ital J Anat Embryol 110:71-5. 2005
    ..Taking in consideration the wide extension of PBP during BDL, aim of our study is to investigate the role of VEGF in stimulating angiogenesis and also in the modulation of epithelial cells proliferation...
  22. doi request reprint New insights on the molecular and cell biology of human cholangiopathies
    Domenico Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, Rome, Italy
    Mol Aspects Med 29:50-7. 2008
    ..Recent advances on the molecular and cell biology of human cholangiopathies are opening new potential therapeutic perspectives for these diseases...
  23. ncbi request reprint Cholangiocytes and blood supply
    Eugenio Gaudio
    Department of Human Anatomy, University of Rome, La Sapienza, Rome, Italy
    World J Gastroenterol 12:3546-52. 2006
    ....
  24. ncbi request reprint Nerve growth factor modulates the proliferative capacity of the intrahepatic biliary epithelium in experimental cholestasis
    Alessandro Gigliozzi
    Division of Gastroenterology, Department of Clinical Medicine, University of Rome La Sapienza, Italy
    Gastroenterology 127:1198-209. 2004
    ..We evaluated the expression of neurotrophins in rat cholangiocytes and the role and mechanisms by which nerve growth factor (NGF) modulates cholangiocyte proliferation...
  25. ncbi request reprint Biliary epithelium: a new chapter in cell biology
    D Alvaro
    Department of Clinical Medicine, University of Rome La Sapienza, Italy
    Ital J Gastroenterol Hepatol 31:78-83. 1999
    ..The aim of this manuscript is to revise recent knowledge on cell biology of the biliary epithelium...
  26. ncbi request reprint Cholangiocarcinoma: risk factors and clinical presentation
    M Gatto
    Department of Clinical Medicine, Division of Gastroenterology, Sapienza University of Rome, Polo Pontino, Rome, Italy
    Eur Rev Med Pharmacol Sci 14:363-7. 2010
    ..A number of serum and bile biomarkers have been recently proposed for the diagnosis of CCA but, their impact on the early diagnosis is still under the evaluation...
  27. ncbi request reprint Effect of ovariectomy on the proliferative capacity of intrahepatic rat cholangiocytes
    Domenico Alvaro
    Division of Gastroenterology, University La Sapienza, Rome, Italy
    Gastroenterology 123:336-44. 2002
    ..We evaluated the effects of ovariectomy (OVX) and estrogen replacement treatment on cholangiocyte proliferation induced by bile duct ligation (BDL)...
  28. ncbi request reprint Administration of r-VEGF-A prevents hepatic artery ligation-induced bile duct damage in bile duct ligated rats
    Eugenio Gaudio
    Division of Anatomy, University La Sapienza, Rome, Italy
    Am J Physiol Gastrointest Liver Physiol 291:G307-17. 2006
    ..The effects of HAL on the PBP and cholangiocyte functions were prevented by r-VEGF-A, which, by maintaining the integrity of the PBP and cholangiocyte proliferation, prevents damage of bile ducts following ischemic injury...
  29. pmc Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma
    Domenico Alvaro
    Department of Clinical Medicine, Division of Gastroenterology, University of Rome, via R Rossellini 51, 00137 Rome, Italy
    Am J Pathol 169:877-88. 2006
    ..Modulation of ER and IGF-1R could represent a strategy for the management of cholangiocarcinoma...
  30. ncbi request reprint Alfa and beta estrogen receptors and the biliary tree
    Domenico Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, University of Rome La Sapienza, Via valsolda 45 i, 00141 Rome, Italy
    Mol Cell Endocrinol 193:105-8. 2002
    ..This indicates a major involvement of the ERK system in the estrogen modulation of cholangiocyte proliferation...
  31. ncbi request reprint Intracellular pathways mediating estrogen-induced cholangiocyte proliferation in the rat
    Domenico Alvaro
    Department of Clinical Medicine, Division of Gastroenterology, University of Rome, La Sapienza, Rome, Italy
    Hepatology 36:297-304. 2002
    ..This might suggest that pharmacologic modulation of ER, ERK, and/or Src could be proposed for the treatment of human pathology characterized by dysregulation of cholangiocyte proliferation...
  32. doi request reprint Cholangiocarcinoma: update and future perspectives
    Manuela Gatto
    Department of Clinical Medicine, Division of Gastroenterology, University of Rome Sapienza, Polo Pontino, R Rosselini 51, Rome, Italy
    Dig Liver Dis 42:253-60. 2010
    ..This manuscript deals with the most recent advances in the epidemiology, biology and clinical presentation of cholangiocarcinoma...
  33. doi request reprint Polycystins play a key role in the modulation of cholangiocyte proliferation
    Alessia Torrice
    Division of Gastroenterology, University of Rome, Sapienza, Rome, Italy
    Dig Liver Dis 42:377-85. 2010
    ..Mutations of PC-1 or PC-2 occur in polycystic liver where cholangiocyte proliferation is enhanced...
  34. ncbi request reprint Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism
    Eugenio Gaudio
    Division of Anatomy, University La Sapienza, Rome, Italy
    Gastroenterology 130:1270-82. 2006
    ..The role of VEGF in cholangiocyte pathophysiology is unknown. We evaluated the role of VEGF in the regulation of cholangiocyte proliferation in rats that underwent bile duct ligation...
  35. ncbi request reprint Estrogen receptors in cholangiocytes and the progression of primary biliary cirrhosis
    Domenico Alvaro
    Division of Gastroenterology, Department of Clinical Medicine, University of Rome, La Sapienza, via R Rossellini 51, 00137 Rome, Italy
    J Hepatol 41:905-12. 2004
    ..Estrogen receptors (ER) in cholangiocytes of primary biliary cirrhosis (PBC) patients and their relationship with cell proliferation and death were evaluated...
  36. doi request reprint Atorvastatin-induced prolonged cholestasis with bile duct damage
    Manuela Merli
    Division of Gastroenterology, Department of Clinical Medicine, University of Rome Sapienza, Rome, Italy
    Clin Drug Investig 30:205-9. 2010
    ..This is a rare case of cholestasis probably caused by atorvastatin and unusually characterized by bile duct damage...
  37. ncbi request reprint Taurocholate feeding prevents CCl4-induced damage of large cholangiocytes through PI3-kinase-dependent mechanism
    Luca Marucci
    Department of Gastroenterology, University of Ancona, Italy
    Am J Physiol Gastrointest Liver Physiol 284:G290-301. 2003
    ..Taurocholate protects cholangiocytes from CCl(4)-induced apoptosis by a PI3-K-dependent mechanism. Bile acids are important in the prevention of drug-induced ductopenia in cholangiopathies...
  38. ncbi request reprint Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin
    Marco Marzioni
    Department of Medical Physiology, Scott and White Hospital, and Texas A and M University Health System Science Center, 702 Southwest H K Dodgen Loop, Temple, TX 76504, USA
    Gastroenterology 128:121-37. 2005
    ..The endogenous factors that regulate cholangiocyte proliferation are poorly understood. Therefore, we studied the role of the neuroendocrine hormone serotonin as a modulator of cholangiocyte proliferation...
  39. ncbi request reprint Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP
    Gene D Lesage
    Department of Medicine, Scott and White Hospital, and The Texas A and M University System HSC, COM, Temple, TX 76504, USA
    Hepatology 40:1116-27. 2004
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  40. pmc Leptin enhances cholangiocarcinoma cell growth
    Giammarco Fava
    Department of Gastroenterology, Universita Politecnica delle Marche, Ancona, Italy
    Cancer Res 68:6752-61. 2008
    ..Modulation of the leptin-mediated signal could be considered a valid tool for the prevention and treatment of cholangiocarcinoma...
  41. ncbi request reprint gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway
    Giammarco Fava
    Central Texas Veterans Health Care System, Research Service, College of Medicine, Temple, 76504, USA
    Cancer Res 65:11437-46. 2005
    ..GABA decreases biliary cancer proliferation and reduces the metastatic potential of cholangiocarcinoma. GABA may represent a therapeutic agent for patients affected by malignancies of the biliary tract...
  42. ncbi request reprint cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway
    Heather Francis
    Division of Research and Education, Scott and White Hospital, The Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76504, USA
    J Hepatol 41:528-37. 2004
    ..To evaluate if increased cholangiocyte cAMP levels alone are sufficient to enhance cholangiocyte proliferation and secretion...
  43. ncbi request reprint Regulation of ERK/JNK/p70S6K in two rat models of liver injury and fibrosis
    Gianluca Svegliati-Baroni
    Clinica di Gastroenterologia, Universita di Ancona, Ospedale Regionale Torrette, Via Conca, 60020 Ancona, Italy
    J Hepatol 39:528-37. 2003
    ..The regulation of three major intracellular signalling protein kinases was investigated in two models of liver injury leading to hepatic fibrosis, dimethylnitrosamine administration (DMN) and bile duct ligation (BDL)...
  44. ncbi request reprint Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct-ligated rats
    Marco Marzioni
    Medical Physiology, Department of Internal Medicine, R and E, Scott and White Hospital, The Texas A and M University System Health Sciences Center, College of Medicine, and Central Texas Veterans Health Care System, Temple, Texas 76504, USA
    Am J Physiol Gastrointest Liver Physiol 284:G837-52. 2003
    ..Bile acids are important in modulating cholangiocyte proliferation in denervated livers...
  45. ncbi request reprint Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats
    Leonardo Baiocchi
    The Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76504, USA
    J Hepatol 38:136-47. 2003
    ..The aim of this study is to determine if the hypercholeretic effect of tauroursodeoxycholate or taurohyodeoxycholate in normal and bile duct ligated (BDL) rats is due to increased ductal secretion...
  46. ncbi request reprint [Pathophysiology of cholangiocytes: recent advances]
    Maria Grazia Mancino
    Divisione di Gastroenterologia, Dipartimento di Medicina Clinica, Universita La Sapienza, Roma
    Recenti Prog Med 98:583-8. 2007
    ..Recent advances on the molecular and cell biology of cholangiocytes are opening new potential therapeutic perspectives for the human chronic liver diseases...
  47. ncbi request reprint Increased susceptibility of cholangiocytes to tumor necrosis factor-alpha cytotoxicity after bile duct ligation
    Gianfranco Alpini
    Department of Internal Medicine, Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76502, USA
    Am J Physiol Cell Physiol 285:C183-94. 2003
    ..Thus TNF-alpha mediates cholangiocyte injury and altered ductal secretion following bile duct ligation. These observations suggest that cholestasis may enhance susceptibility to cytokine-mediated cholangiocyte injury...
  48. ncbi request reprint Estrogens maintain bile duct mass and reduce apoptosis after biliodigestive anastomosis in bile duct ligated rats
    Gianluca Svegliati-Baroni
    Clinica di Gastroenterologia, Universita Politecnica delle Marche, INRCA, IRCCS, Via Tronto, Ancona, 60020, Italy
    J Hepatol 44:1158-66. 2006
    ..We thus evaluated whether estrogen administration protect from the bile duct loss induced by the biliary-digestive diversion in bile duct ligated (BDL) rats...
  49. ncbi request reprint Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats
    Gianfranco Alpini
    Department of Internal Medicine, Scott and White Hospital and The Texas A and M University System Health Science Center College of Medicine, and Central Texas Veterans Health Care System, Temple, Texas, USA
    Gastroenterology 123:1226-37. 2002
    ..We tested the hypothesis that during bile duct obstruction, increased biliary bile acids trigger cholangiocyte proliferation and secretion by a phosphatidylinositol 3-kinase (PI3-K)-dependent pathway...
  50. ncbi request reprint The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats
    Heather Francis
    Central Texas Veterans Health Care System, The Texas A and M University System Health Science Center College of Medicine, Medical Research Bldg, Temple, TX 76504, USA
    Am J Physiol Cell Physiol 293:C1252-62. 2007
    ..alpha(2)-Adrenergic receptors play a role in counterregulating enhanced ductal secretion associated with cholangiocyte proliferation in chronic cholestatic liver diseases...
  51. ncbi request reprint Activation of the IGF1 system characterizes cholangiocyte survival during progression of primary biliary cirrhosis
    Paolo Onori
    Department of Experimental Medicine, University of L Aquila, Italy
    J Histochem Cytochem 55:327-34. 2007
    ..This was associated and correlated with a balance of pro- and antiapoptotic proteins favoring survival rather than apoptosis, suggesting a major role of IGF1 system in promoting cholangiocyte survival...
  52. ncbi request reprint Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver
    Marco Marzioni
    Department of Gastroenterology, Universita Politecnica delle Marche, Ancona, Italy
    Liver Int 27:558-68. 2007
    ..Bile acids and neurotransmitters co-operatively regulate the biological response of the biliary epithelium to cholestasis. Adrenergic denervation of the liver during cholestasis results in the damage of bile ducts...
  53. pmc H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway
    Heather Francis
    Department of Research and Education, College of Medicine, Scott and White Hospital and The Texas A and M University System Health Science Center, Temple, TX 76504, USA
    Lab Invest 87:473-87. 2007
    ..Downregulation of cAMP-dependent PKA/ERK1/2/Elk-1 phosphorylation (by activation of H3R) is important in the inhibition of cholangiocyte growth in liver diseases...
  54. ncbi request reprint Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity
    Shannon Glaser
    Department of Internal Medicine, Texas A and M University System Health Sciences Center, College of Medicine, Temple, Texas 76504, USA
    Am J Physiol Gastrointest Liver Physiol 284:G683-94. 2003
    ..The dopaminergic nervous system counterregulates secretin-stimulated ductal secretion in experimental cholestasis...
  55. ncbi request reprint Gastrin reverses established cholangiocyte proliferation and enhanced secretin-stimulated ductal secretion of BDL rats by activation of apoptosis through increased expression of Ca2+- dependent PKC isoforms
    Sharon Glaser
    Division of Research and Education, Scott and White Hospital and The Texas A and M University System Health Science Center, College of Medicine, 76504, USA
    Liver Int 23:78-88. 2003
    ..SUMMARY/CONCLUSION: Gastrin inhibits cholangiocyte proliferation and secretin-induced ductal secretion in BDL rats by increasing apoptosis through a PKC-mediated mechanism...
  56. ncbi request reprint Tamoxifen in treatment of primary biliary cirrhosis
    Pietro Invernizzi
    Hepatology 39:1175-6. 2004
  57. ncbi request reprint Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity
    Gene D Lesage
    Department of Internal Medicine, Scott and White Hospital and The Texas A and M University System HSC COM, Temple, TX, USA
    Hepatology 36:641-51. 2002
    ..In conclusion, insulin counter-regulates cholangiocyte secretory processes in the BDL model, which is characterized by cholangiocyte proliferation...
  58. ncbi request reprint Hepatic "stem" cells: state of the art
    Maria Grazia Mancino
    Department of Human Anatomy, Italy State University La Sapienza of Rome
    Ital J Anat Embryol 112:93-109. 2007
    ..The aim of the present review is to update readers with the evolving concepts about hepatic stem cells biology, their characterization and isolation methods and finally their therapeutic potential...
  59. ncbi request reprint Adrenergic receptor agonists prevent bile duct injury induced by adrenergic denervation by increased cAMP levels and activation of Akt
    Shannon Glaser
    Division of Research and Education, College of Medicine, Scott and White Hospital and The Texas A and M University System Health Science Center, Temple, 76504, USA
    Am J Physiol Gastrointest Liver Physiol 290:G813-26. 2006
    ..In conclusion, we propose that adrenergic innervation plays a role in the regulation of biliary mass and cholangiocyte functions during BDL by modulating intracellular cAMP levels...