Emilio Paolo Alessandrino

Summary

Affiliation: University of Pavia
Country: Italy

Publications

  1. ncbi request reprint Reduced-intensity conditioning regimen with thiotepa and fludarabine followed by allogeneic blood stem cell transplantation in haematological malignancies
    E P Alessandrino
    Bone Marrow Transplantation Unit, Division of Haematology, IRCCS Policlinico San Matteo, Viale Golgi N 19, Pavia 27100, Italy
    Bone Marrow Transplant 34:1039-45. 2004
  2. pmc Prognostic impact of pre-transplantation transfusion history and secondary iron overload in patients with myelodysplastic syndrome undergoing allogeneic stem cell transplantation: a GITMO study
    Emilio Paolo Alessandrino
    Department of Hematology Oncology, University of Pavia, Fondazione Policlinico San Matteo, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Pavia, Italy
    Haematologica 95:476-84. 2010
  3. ncbi request reprint Thiotepa and fludarabine (TT-FLUDA) as conditioning regimen in poor candidates for conventional allogeneic hemopoietic stem cell transplant
    E P Alessandrino
    Centro Trapianti di Midollo Osseo, Istituto di Ematologia, IRCCS Policlinico S Matteo, Pavia, Italy
    Ann Hematol 80:521-4. 2001
  4. doi request reprint WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome: a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO)
    Emilio Paolo Alessandrino
    Division of Hematology, University of Pavia, Fondazione Policlinico San Matteo, Istituti di Ricovero e Cura a Carattere Scientifico IRCCS, Pavia, Italy
    Blood 112:895-902. 2008
  5. doi request reprint Immunochemotherapy with in vivo purging and autotransplant induces long clinical and molecular remission in advanced relapsed and refractory follicular lymphoma
    L Arcaini
    Division of Hematology, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia
    Ann Oncol 19:1331-5. 2008
  6. doi request reprint Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients
    Maurizia Debiaggi
    Department of Morphological and Clinical Sciences, Section of Microbiology, University of Pavia, Pavia, Italy
    J Med Virol 82:153-6. 2010
  7. ncbi request reprint A model of in vivo purging with Rituximab and high-dose AraC in follicular and mantle cell lymphoma
    L Arcaini
    Division of Hematology, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Bone Marrow Transplant 34:175-9. 2004
  8. pmc Differential outcome of neurological HCMV infection in two hematopoietic stem cell transplant recipients
    Anna Amelia Colombo
    Centro Trapianti di Midollo Osseo, Istituto di Ematologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    BMC Infect Dis 12:238. 2012
  9. doi request reprint Human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in adult allogeneic hematopoietic stem cell transplant recipients and immune control of viral infection
    Daniele Lilleri
    Servizio di Virologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    Haematologica 93:248-56. 2008
  10. ncbi request reprint Limited feasibility of double transplant in multiple myeloma: results of a multicenter study on 153 patients aged <65 years
    Alessandro Corso
    Division of Hematology, IRCCS Fondazione Policlinico San Matteo University of Pavia, Pavia, Italy
    Cancer 109:2273-8. 2007

Detail Information

Publications23

  1. ncbi request reprint Reduced-intensity conditioning regimen with thiotepa and fludarabine followed by allogeneic blood stem cell transplantation in haematological malignancies
    E P Alessandrino
    Bone Marrow Transplantation Unit, Division of Haematology, IRCCS Policlinico San Matteo, Viale Golgi N 19, Pavia 27100, Italy
    Bone Marrow Transplant 34:1039-45. 2004
    ..In total, 12 patients remain in complete remission (median follow-up: 786 days). The 3-year overall survival probability was 58%. We conclude that this regimen is feasible and well tolerated...
  2. pmc Prognostic impact of pre-transplantation transfusion history and secondary iron overload in patients with myelodysplastic syndrome undergoing allogeneic stem cell transplantation: a GITMO study
    Emilio Paolo Alessandrino
    Department of Hematology Oncology, University of Pavia, Fondazione Policlinico San Matteo, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Pavia, Italy
    Haematologica 95:476-84. 2010
    ..Secondary iron overload may concur to this effect. The relative impact of these factors on the outcome of patients with myelodysplastic syndrome receiving allogeneic stem-cell transplantation remains to be clarified...
  3. ncbi request reprint Thiotepa and fludarabine (TT-FLUDA) as conditioning regimen in poor candidates for conventional allogeneic hemopoietic stem cell transplant
    E P Alessandrino
    Centro Trapianti di Midollo Osseo, Istituto di Ematologia, IRCCS Policlinico S Matteo, Pavia, Italy
    Ann Hematol 80:521-4. 2001
    ..TT-FLUDA seems to be well tolerated, allowing engraftment and stable donor chimerism in patients who are poor candidates for conventional conditioning regimens...
  4. doi request reprint WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome: a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO)
    Emilio Paolo Alessandrino
    Division of Hematology, University of Pavia, Fondazione Policlinico San Matteo, Istituti di Ricovero e Cura a Carattere Scientifico IRCCS, Pavia, Italy
    Blood 112:895-902. 2008
    ..013 and P = .031, respectively). In these patients, WPSS identified 2 groups with different OS and TRM. These data suggest that WHO classification and WPSS have a relevant prognostic value in posttransplantation outcome of MDS patients...
  5. doi request reprint Immunochemotherapy with in vivo purging and autotransplant induces long clinical and molecular remission in advanced relapsed and refractory follicular lymphoma
    L Arcaini
    Division of Hematology, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia
    Ann Oncol 19:1331-5. 2008
    ..To evaluate the clinical outcome of patients with relapsed or refractory follicular lymphoma treated with immunochemotherapy, in vivo purging and high-dose therapy with autotransplant...
  6. doi request reprint Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients
    Maurizia Debiaggi
    Department of Morphological and Clinical Sciences, Section of Microbiology, University of Pavia, Pavia, Italy
    J Med Virol 82:153-6. 2010
    ..The results suggest that WU/KIPyVs have a limited circulation in Italy and a low pathogenic potential in young children. Brief and asymptomatic infection can occur in hematopoietic transplant recipients...
  7. ncbi request reprint A model of in vivo purging with Rituximab and high-dose AraC in follicular and mantle cell lymphoma
    L Arcaini
    Division of Hematology, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Bone Marrow Transplant 34:175-9. 2004
    ..Immunochemotherapy prior to mobilization produces B-cell depletion and seems to be a useful preparative step...
  8. pmc Differential outcome of neurological HCMV infection in two hematopoietic stem cell transplant recipients
    Anna Amelia Colombo
    Centro Trapianti di Midollo Osseo, Istituto di Ematologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    BMC Infect Dis 12:238. 2012
    ..Diagnosis, monitoring and treatment approaches rely on anecdotal reports...
  9. doi request reprint Human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in adult allogeneic hematopoietic stem cell transplant recipients and immune control of viral infection
    Daniele Lilleri
    Servizio di Virologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    Haematologica 93:248-56. 2008
    ..We investigated the development of human cytomegalovirus-specific T cells in adult recipients of hematopoietic stem cell transplants...
  10. ncbi request reprint Limited feasibility of double transplant in multiple myeloma: results of a multicenter study on 153 patients aged <65 years
    Alessandro Corso
    Division of Hematology, IRCCS Fondazione Policlinico San Matteo University of Pavia, Pavia, Italy
    Cancer 109:2273-8. 2007
    ..The current study was conducted to evaluate the efficacy and the feasibility of a front-line double transplant program in young MM patients...
  11. ncbi request reprint The VAD-DCEP sequence is an effective pre-transplant therapy in untreated multiple myeloma
    Alessandro Corso
    The Division of Hematology from IRCCS Policlinico S Matteo University of Pavia, Ospedale Niguarda Milano, Italy
    Haematologica 89:1124-7. 2004
    ..The aim of this study was to evaluate the efficacy of a new regimen and compare it with that of a previous regimen...
  12. ncbi request reprint Consolidation treatment with autologous peripheral blood progenitor cell transplantation in acute myeloid leukemia: a single center experience
    C Castagnola
    Divisione di Ematologia, IRCCS Policlinico S Matteo, Istituto di Ematologia, Universita degli Studi di Pavia, Italy
    Ann Hematol 80:267-71. 2001
    ..Randomized studies should be performed to evaluate whether this form of consolidation may produce a significant improvement in leukemia-free survival...
  13. ncbi request reprint DCEP (dexamethasone, cyclophosphamide, etoposide, and cisplatin) is an effective regimen for peripheral blood stem cell collection in multiple myeloma
    M Lazzarino
    Division of Hematology, IRCCS Policlinico S Matteo, University of Pavia, Italy
    Bone Marrow Transplant 28:835-9. 2001
    ..These properties render DCEP a useful regimen for the debulking and mobilization phase of high-dose programs for multiple myeloma...
  14. ncbi request reprint A sequence of immuno-chemotherapy with Rituximab, mobilization of in vivo purged stem cells, high-dose chemotherapy and autotransplant is an effective and non-toxic treatment for advanced follicular and mantle cell lymphoma
    M Lazzarino
    Division of Hematology, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy
    Br J Haematol 116:229-35. 2002
    ..It permits rapid attainment of clinical and molecular response and enables the harvest of lymphoma-free peripheral blood progenitor cells even in heavily pretreated patients with relapsed or refractory disease...
  15. doi request reprint Validation of a DNAemia cutoff for preemptive therapy of cytomegalovirus infection in adult hematopoietic stem cell transplant recipients
    G Gerna
    Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Bone Marrow Transplant 41:873-9. 2008
    ..In conclusion, our study shows that the use of a cutoff significantly reduces the number of patients requiring antiviral treatment, thus sparing unnecessary drug administration...
  16. ncbi request reprint N-acetylcysteine in the treatment of steroid-resistant acute graft-versus-host-disease: preliminary results. Gruppo Italiano Trapianto di Midollo Osseo (GITMO)
    A A Colombo
    Istituto di Ematologia, IRCCS Policlinico S Matteo, Pavia, Italy
    Transplantation 68:1414-6. 1999
    ..N-Acetylcysteine (NAC) is an antioxidant that inhibits the B7-1/CD28 expression in vitro, and it may contrabalance the effects of free radicals and oxidative stress; it has been tested in eight patients with steroid-resistant acute GVHD...
  17. ncbi request reprint Persistent symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients
    Maurizia Debiaggi
    Dipartimento di Scienze Morfologiche, Eidologiche e Cliniche, Sezione di Microbiologia, Universita di Pavia, via Brambilla, 74, 27100, Pavia, Italy
    J Infect Dis 194:474-8. 2006
    ..The data indicate that HSCT recipients may frequently develop symptomless hMPV infection...
  18. ncbi request reprint Rising antigenemia levels may be misleading in pre-emptive therapy of human cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients
    Giuseppe Gerna
    Servizio di Virologia, Oncoematologia Pediatrica, and Centro Trapianti di Midollo Osseo, Divisione di Ematologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    Haematologica 90:526-33. 2005
    ..This raises some doubts about the therapeutic decisions to be taken...
  19. ncbi request reprint Incidence of human cytomegalovirus infection in patients with refractory solid tumors receiving nonmyeloablative allogeneic stem cell transplants versus recipients of standard SCT for hematologic malignancies
    A Zambelli
    U O Oncologia Medica I, IRCCS, Fondazione Salvatore Maugeri, Pavia, Italy
    Biol Blood Marrow Transplant 11:423-8. 2005
    ..001) and earlier ( P = .001) than in NST patients. Patients affected with solid tumors undergoing NST had a reduced and delayed incidence of HCMV active infection...
  20. ncbi request reprint Flexural erythematous eruption following autologous peripheral blood stem cell transplantation: a study of four cases
    V Brazzelli
    Department of Human and Hereditary Pathology, Institute of Dermatology and Institute of Haematology, University of Pavia, IRCCS Policlinico San Matteo, Piazzale Golgi 2, 27100 Pavia, Italy
    Br J Dermatol 145:490-5. 2001
    ....
  21. ncbi request reprint Evidence- and consensus-based practice guidelines for the therapy of primary myelodysplastic syndromes. A statement from the Italian Society of Hematology
    Emilio Paolo Alessandrino
    Divisione di Ematologia, IRCCS Policlinico S Matteo, Pavia, Italy
    Haematologica 87:1286-306. 2002
    ..The Italian Society of Hematology commissioned a project to develop guidelines for the therapy of MDS using evidence-based knowledge and consensus-formation techniques...
  22. ncbi request reprint Hepatitis reactivation and liver failure in haemopoietic stem cell transplants for hepatitis B virus (HBV)/hepatitis C virus (HCV) positive recipients: a retrospective study by the Italian group for blood and marrow transplantation
    A Locasciulli
    Ematologia e Trapianto di Midollo, Ospedale S Camillo Forlanoini, Rome, Italy
    Bone Marrow Transplant 31:295-300. 2003
    ..Our results indicate that HBV and HCV infection should not be taken as an absolute contraindication for HSCT and the risk of life-threatening liver complications are similar after allogeneic or autologous transplants...
  23. ncbi request reprint Mycobacterial infection: a difficult and late diagnosis in stem cell transplant recipients
    C Cordonnier
    Department of Hematology, Henri Mondor Hospital, Assistance Publique Hopitaux de Paris, Creteil, France
    Clin Infect Dis 38:1229-36. 2004
    ..Because of the increased numbers of unmatched donors and transplantation programs in countries with a high prevalence of tuberculosis, constant vigilance is required to early detect MBI in SCT recipients...