Research Topics
| Giancarlo AldiniSummaryAffiliation: University of Milan Country: Italy Publications
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Detail Information
Publications
Advanced analytical strategies for recombinant therapeutic proteinsGiancarlo Aldini
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, University of Milan Via Mangiagalli 25, 20133 Milan, Italy
Curr Pharm Biotechnol 12:1507. 2011....- Detoxification of cytotoxic alpha,beta-unsaturated aldehydes by carnosine: characterization of conjugated adducts by electrospray ionization tandem mass spectrometry and detection by liquid chromatography/mass spectrometry in rat skeletal muscleGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Mass Spectrom 37:1219-28. 2002..The results indicate that beside GSH, histidine-containing dipeptides could be involved in the detoxification pathway of reactive aldehydes from lipid peroxidation generated in skeletal muscle during physical endurance... 
The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese ratsGiancarlo Aldini
Department of Pharmaceutical Sciences Pietro Pratesi, Universita degli Studi di Milano, Milan, Italy
J Cell Mol Med 15:1339-54. 2011....- Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonylsGiancarlo Aldini
Institute of Pharmaceutical and Toxicological Chemistry, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, I 20131, Milan, Italy
Med Res Rev 27:817-68. 2007..Inhibition of ALE formation, based on carbonyl-sequestering agents, seems to be the most promising pharmacological tool and is reviewed in detail... - Mass spectrometric characterization of covalent modification of human serum albumin by 4-hydroxy-trans-2-nonenalGiancarlo Aldini
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, I 20131 Milan, Italy
J Mass Spectrom 41:1149-61. 2006..These albumin modifications are suitable tags of HNE-adducted albumin and could be useful biomarkers of oxidative and carbonylation damage in humans... - Electron spin resonance and chemiluminescence analyses to elucidate the vasodilating mechanism of sodium nitroprussideGiancarlo Aldini
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
Mol Pharmacol 70:1672-80. 2006..In conclusion, SNP is rapidly metabolized to HbFe(II)NO, but the pharmacological response is mediated by a direct mechanism of NO release of the parent compound at the cellular target... - Alpha,beta-unsaturated aldehydes adducts to actin and albumin as potential biomarkers of carbonylation damageGiancarlo Aldini
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, Milan, Italy
Redox Rep 12:20-5. 2007.... - Profiling histidine-containing dipeptides in rat tissues by liquid chromatography/electrospray ionization tandem mass spectrometryGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Mass Spectrom 39:1417-28. 2004..HCAR was found only in the brain and cerebellum. No histidine-containing dipeptides were detectable in plasma, liver, kidney and lung... - Covalent modification of actin by 4-hydroxy-trans-2-nonenal (HNE): LC-ESI-MS/MS evidence for Cys374 Michael adductionGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, I 20131 Milan, Italy
J Mass Spectrom 40:946-54. 2005..Computational studies showed that the reactivity of Cys374 residue is due to a significant accessible surface and substantial thiol acidity due to the particular microenvironment surrounding Cys374... - Detoxification of 4-hydroxynonenal (HNE) in keratinocytes: characterization of conjugated metabolites by liquid chromatography/electrospray ionization tandem mass spectrometryGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Mass Spectrom 38:1160-8. 2003..This is the first demonstration that skin epidermal cells are able to detoxify the cytotoxic products of lipid peroxidation... - Identification of actin as a 15-deoxy-Delta12,14-prostaglandin J2 target in neuroblastoma cells: mass spectrometric, computational, and functional approaches to investigate the effect on cytoskeletal derangementGiancarlo Aldini
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, I 20131 Milan, Italy
Biochemistry 46:2707-18. 2007.... - Procyanidins from grape seeds protect endothelial cells from peroxynitrite damage and enhance endothelium-dependent relaxation in human artery: new evidences for cardio-protectionGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42 20131 Milan, Italy
Life Sci 73:2883-98. 2003.... - A tandem MS precursor-ion scan approach to identify variable covalent modification of albumin Cys34: a new tool for studying vascular carbonylationGiancarlo Aldini
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, Via Mangiagalli 25, I 20133 Milan, Italy
J Mass Spectrom 43:1470-81. 2008.... - Metabolic profile of NO-flurbiprofen (HCT1026) in rat brain and plasma: a LC-MS studyGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
Life Sci 71:1487-500. 2002..These data indicate that the NO molecule is not released from the parent drug within the brain... - Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction?Giancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
Biochem Biophys Res Commun 298:699-706. 2002..The biological role of carnosine as a quencher of alpha,beta-unsaturated aldehydes was verified by detecting carnosine-HNE reaction adducts in oxidized rat skeletal muscle homogenate... - Carnosine and related dipeptides as quenchers of reactive carbonyl species: from structural studies to therapeutic perspectivesGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
Biofactors 24:77-87. 2005.... - Albumin is the main nucleophilic target of human plasma: a protective role against pro-atherogenic electrophilic reactive carbonyl species?Giancarlo Aldini
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, I 20131, Milan, Italy
Chem Res Toxicol 21:824-35. 2008..81 +/- 0.17 M (-1) s (-1)), as explained by molecular modeling studies. In conclusion, we suggest that albumin, through nucleophilic residues, and in particular Cys34, can act as an endogenous detoxifying agent of circulating RCS... - Effects of UVB radiation on 4-hydroxy-2-trans-nonenal metabolism and toxicity in human keratinocytesGiancarlo Aldini
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, I 20131 Milan, Italy
Chem Res Toxicol 20:416-23. 2007.... - An integrated high resolution mass spectrometric and informatics approach for the rapid identification of phenolics in plant extractGiancarlo Aldini
Department of Pharmaceutical Sciences Pietro Pratesi, Universita degli Studi di Milano, Milan, Italy
J Chromatogr A 1218:2856-64. 2011..The method was then successfully applied for the rapid identification of phenolics contained in an EtOH extract of Angelica keiskei... - Nitrosylhemoglobin formation after infusion of NO solutions: ESR studies in pigsGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, Milan 20131, Italy
Biochem Biophys Res Commun 318:405-14. 2004..Thus, in normoxic/physiological conditions, HbFe(II)NO does not induce significant NO-dependent vasorelaxation... - Protein carbonylation: 2,4-dinitrophenylhydrazine reacts with both aldehydes/ketones and sulfenic acidsIsabella Dalle-Donne
Department of Biology, University of Milan, Italy
Free Radic Biol Med 46:1411-9. 2009..beta-Mercaptoethanol prevents the formation of the DNPH derivative because it reacts with the oxidized Cys residue, forming the corresponding disulfide... - Design, synthesis, ADME properties, and pharmacological activities of β-alanyl-D-histidine (D-carnosine) prodrugs with improved bioavailabilityMarica Orioli
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Universita degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy
ChemMedChem 6:1269-82. 2011.... - Water-Soluble alpha,beta-unsaturated aldehydes of cigarette smoke induce carbonylation of human serum albuminGraziano Colombo
Dipartimento di Biologia, Universita degli Studi di Milano, Milan, Italy
Antioxid Redox Signal 12:349-64. 2010..Carbonylation of HSA associated with cigarette smoking might result in modifications of its antioxidant properties and transport functions of both endogenous and exogenous compounds... - Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mappingAlessandro Pedretti
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Facolta di Farmacia, Universita degli Studi di Milano, Via Mangiagalli, 25, I 20133 Milano, Italy
Bioorg Med Chem 19:4544-51. 2011.... - Total antioxidant performance: a validated fluorescence assay for the measurement of plasma oxidizabilityGiangiacomo Beretta
Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, 20143 Milan, Italy
Anal Biochem 354:290-8. 2006..93, P<0.01). The results confirm that the TAP assay is suitable to measure the antioxidant activity of plasma antioxidants localized in both the lipophilic and hydrophilic compartments... - Actin Cys374 as a nucleophilic target of alpha,beta-unsaturated aldehydesIsabella Dalle-Donne
Department of Biology, University of Milan, Via Celoria 26, I 20133 Milan, Italy
Free Radic Biol Med 42:583-98. 2007.... - Oxidative damage in human gingival fibroblasts exposed to cigarette smokeGraziano Colombo
Department of Biology, Universita degli Studi di Milano, I 20133 Milan, Italy
Free Radic Biol Med 52:1584-96. 2012..GSH depletion could be a mechanism for cigarette smoke-induced cytotoxicity and could be correlated with the reduced reparative and regenerative activity of gingival and periodontal tissues previously reported in smokers... - Design, synthesis, and evaluation of carnosine derivatives as selective and efficient sequestering agents of cytotoxic reactive carbonyl speciesGiulio Vistoli
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Facolta di Farmacia, Universita degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy
ChemMedChem 4:967-75. 2009..This study describes a set of aryl derivatives that are characterized by high stability in human plasma and a quenching activity toward 4-hydroxy-trans-2-nonenal (HNE), chosen as a model of RCS, up to threefold greater than D-carnosine... - Nitric oxide release and distribution following oral and intraperitoneal administration of nitroaspirin (NCX 4016) in the ratMarina Carini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
Life Sci 74:3291-305. 2004..This indicates that NCX 4016 does not undergo biotransformation in the upper part of gastrointestinal tract (no direct release of NO in this district) and that the stomach acts as a reservoir for the drug... - LC-ESI-MS/MS determination of 4-hydroxy-trans-2-nonenal Michael adducts with cysteine and histidine-containing peptides as early markers of oxidative stress in excitable tissuesMarica Orioli
Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 827:109-18. 2005.... - Lipoxidation-derived reactive carbonyl species as potential drug targets in preventing protein carbonylation and related cellular dysfunctionGiancarlo Aldini
Institute of Pharmaceutical and Toxicological Chemistry Pietro Pratesi, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131, Milan, Italy
ChemMedChem 1:1045-58. 2006 - Chemiluminescence and LC-MS/MS analyses for the study of nitric oxide release and distribution following oral administration of nitroaspirin (NCX 4016) in healthy volunteersMarina Carini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Pharm Biomed Anal 35:277-87. 2004..0 +/- 0.6 h versus 5.4 +/- 1.2 h)... - A combined high-resolution mass spectrometric and in silico approach for the characterisation of small ligands of beta2-microglobulinLuca Regazzoni
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Universita degli Studi di Milano, Via Mangiagalli 25, Milan, Italy
ChemMedChem 5:1015-25. 2010..Overall, this approach can be used for predictive purposes and for a rapid screening of fibrillogenesis inhibitors... - Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: focus on reactivity, selectivity, and reaction mechanismsGiancarlo Aldini
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Universita degli Studi di Milano, Milan, Italy
Antioxid Redox Signal 12:381-92. 2010..The same combined approach indicated that EDA is not a selective RCS scavenger, being able to react also with nontoxic, physiologically relevant aldehydes, such as pyridoxal... - HNE Michael adducts to histidine and histidine-containing peptides as biomarkers of lipid-derived carbonyl stress in urines: LC-MS/MS profiling in Zucker obese ratsMarica Orioli
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, Via Mangiagalli 25, I 20133 Milan, Italy
Anal Chem 79:9174-84. 2007.... - Antioxidant and photoprotective activity of a lipophilic extract containing neolignans from Krameria triandra rootsMarina Carini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Italy
Planta Med 68:193-7. 2002..The results of this study indicate the potential use of Rhatany extracts, standardized in neolignans, as topical antioxidants/radical scavengers against skin photodamage... - Protein modification by acrolein: relevance to pathological conditions and inhibition by aldehyde sequestering agentsGiancarlo Aldini
Department of Pharmaceutical Sciences Pietro Pratesi, Universita degli Studi di Milano, Milan, Italy
Mol Nutr Food Res 55:1301-19. 2011.... - Hemoglobin glutathionylation can occur through cysteine sulfenic acid intermediate: electrospray ionization LTQ-Orbitrap hybrid mass spectrometry studiesLuca Regazzoni
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Universita degli Studi di Milano, Milan, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 877:3456-61. 2009..Hb glutathionylation is also mediated by a thiol-disulfide transfer mechanism, but this requires a concentration of GSSG which is far to be achieved in physiopathological conditions... - Modeling of the intestinal peptide transporter hPepT1 and analysis of its transport capacities by docking and pharmacophore mappingAlessandro Pedretti
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Facolta di Farmacia, Universita degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy
ChemMedChem 3:1913-21. 2008.... - Acrolein-sequestering ability of endogenous dipeptides: characterization of carnosine and homocarnosine/acrolein adducts by electrospray ionization tandem mass spectrometryMarina Carini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Mass Spectrom 38:996-1006. 2003.... - Transforming dietary peptides in promising lead compounds: the case of bioavailable carnosine analogsGiulio Vistoli
Department of Pharmaceutical Sciences Pietro Pratesi, Universita degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy
Amino Acids 43:111-26. 2012..The review also includes a brief description of AGEs and ALEs as drug targets and the evidence so far reported regarding the ability of carnosine as inhibitor of AGEs and ALEs formation and the proposed reaction mechanisms... - A sensitive and specific precursor ion scanning approach in liquid chromatography/electrospray ionization tandem mass spectrometry to detect methylprednisolone acetate and its metabolites in rat urineAlessia Panusa
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Universita degli Studi di Milano, Via L Mangiagalli 25, 20133 Milan, Italy
Rapid Commun Mass Spectrom 24:1583-94. 2010..Six different metabolites were detected in rat urine, and their chemical structures were assigned with a computational study... - In vitro metabolism of a nitroderivative of acetylsalicylic acid (NCX4016) by rat liver: LC and LC-MS studiesMarina Carini
Istituto Chimico Farmaceutico Tossicologico, Viale Abruzzi 42, Milan, Italy
J Pharm Biomed Anal 29:1061-71. 2002..The relevance of this new metabolic pathway in NCX4016 detoxification by rat liver is discussed... - (-)-Epigallocatechin-3-gallate prevents oxidative damage in both the aqueous and lipid compartments of human plasmaGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Milan, Italy
Biochem Biophys Res Commun 302:409-14. 2003..Further, ESR experiments confirmed that EGCG recycled alpha-tocopherol through a H-transfer mechanism at the aqueous/lipid interface affording an additional protective mechanism to the lipid compartment of plasma... - A rapid and sensitive LC-ESI-MS/MS method for detection and quantitation of methylprednisolone and methylprednisolone acetate in rat plasma after intra-articular administrationAlessia Panusa
Dipartimento di Scienze Farmaceutiche P Pratesi, Universita degli Studi di Milano, 20133 Milan, Italy
J Pharm Biomed Anal 51:691-7. 2010..080 and 0.072pmol injected for MP and MPA, respectively). The method was successfully applied to monitor the plasma levels of MPA and MP following intra-articular (IA) injections of a low MPA (Depo-Medrol((R))) dose in rats... - Homology modeling of human serum carnosinase, a potential medicinal target, and MD simulations of its allosteric activation by citrateGiulio Vistoli
Istituto di Chimica Farmaceutica, Facolta di Farmacia, Universita di Milano, Viale Abruzzi 42, I 20131 Milano, Italy
J Med Chem 49:3269-77. 2006..e., binding score) of carnosine to the catalytic site. This is one of the first reports documenting the molecular mechanism of an allosteric enzyme activator using MD simulations... - The potential of resveratrol against human gliomasNicoletta Gagliano
Department of Human Morphology and Biomedical Sciences Citta Studi, Universita di Milano, School of Medicine, Extracellular Matrix Laboratory, Via Fratelli Cervi 93, 20090 Segrate, Milan, Italy
Anticancer Drugs 21:140-50. 2010..This study discusses current knowledge with regard to the effects of resveratrol in relation to its potential as a chemopreventive and/or chemotherapeutic molecule against human gliomas... - Protein carbonylation, cellular dysfunction, and disease progressionIsabella Dalle-Donne
Department of Biology, University of Milan, Italy
J Cell Mol Med 10:389-406. 2006.... - Screening of fibrillogenesis inhibitors of β2-microglobulin: integrated strategies by mass spectrometry capillary electrophoresis and in silico simulationsLuca Regazzoni
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Universita degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy
Anal Chim Acta 685:153-61. 2011..Studies on the new hit thus retrieved confirm the predictive potential of both the equation on affinity and of docking analysis on anti-amyloid activity... - Mass spectrometry for detection of 4-hydroxy-trans-2-nonenal (HNE) adducts with peptides and proteinsMarina Carini
Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
Mass Spectrom Rev 23:281-305. 2004.... 
D-Carnosine octylester attenuates atherosclerosis and renal disease in ApoE null mice fed a Western diet through reduction of carbonyl stress and inflammationStefano Menini
Department of Clinical and Molecular Medicine, La Sapienza University of Rome, Rome, Italy
Br J Pharmacol 166:1344-56. 2012..This study aimed at assessing the effect of the carnosinase-resistant, D-carnosine, on HNE-induced cellular injury and of its bioavailable prodrug D-carnosine octylester on experimental atherosclerosis and renal disease...- Mass spectrometric strategies and their applications for molecular mass determination of recombinant therapeutic proteinsMarina Carini
Department of Pharmaceutical Sciences Pietro Pratesi, Universita degli Studi di Milano, Milan, Italy
Curr Pharm Biotechnol 12:1548-57. 2011..The paper is a review of the most used and advanced MS strategies so far reported as well as of their applications in the biopharmaceutical field... - En bloc elution of proteomes from combinatorial peptide ligand librariesAlessia Farinazzo
Department of Chemistry, Materials and Chemical Engineering Giulio Natta, Politecnico di Milano, Via Mancinelli 7, Milan, Italy
J Proteomics 72:725-30. 2009.... - Molecular recognition of T:G mismatched base pairs in DNA as studied by electrospray ionization mass spectrometryFederico Riccardi Sirtori
Oncology Business Unit, Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano MI, Italy
ChemMedChem 7:1112-22. 2012..Our results confirm that this ESI method could be a valuable tool for the identification of new molecules able to specifically recognize T:G mismatched base pairs... - S-nitrosation versus S-glutathionylation of protein sulfhydryl groups by S-nitrosoglutathioneDaniela Giustarini
Department of Neuroscience, Pharmacology Unit, University of Siena, Siena, Italy
Antioxid Redox Signal 7:930-9. 2005..The susceptibility of the modified proteins to denitrosation and deglutathionylation by reduced glutathione was also investigated... - Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal womenXianfeng Zhao
Jean Mayer USDA-Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 83:163-9. 2006.... - Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosisClaudio Napoli
Department of Medicine, Federico II University of Naples, 80131 Naples, Italy
Proc Natl Acad Sci U S A 99:1689-94. 2002..We suggest that an NCX-4016 derivative could be an effective drug in reducing restenosis, especially in the presence of aging and/or gastrointestinal damage... - Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokersGiovanni B Vigna
Department of Clinical and Experimental Medicine, Section of Internal Medicine II, University of Ferrara, Ferrara, Italy
Metabolism 52:1250-7. 2003..The antioxidant potential of grape seed extract polyphenols may prove effective in a model of oxidative stress (smoking); however more investigational data are needed before use in wider clinical settings... - The activities of antioxidant nutrients in human plasma depend on the localization of attacking radical speciesKyung Jin Yeum
The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
J Nutr 133:2688-91. 2003..Our study indicates that the antioxidant nutrients present in both the lipid and aqueous compartments can remove free radicals generated in plasma, and their activity depends on the localization of the attacking radical species... - Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasmaKyung Jin Yeum
The Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Arch Biochem Biophys 430:97-103. 2004..Revelation of the mechanism of action of antioxidants and their true antioxidant potential will help us to optimize the antioxidant defenses in the body...