G Agnelli

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. ncbi request reprint Unresolved issues in the prevention and treatment of venous thromboembolism
    Giancarlo Agnelli
    University of Perugia, Perugia, Italy
    Semin Thromb Hemost 28:33-40. 2002
  2. ncbi request reprint Long-term therapy of pulmonary embolism
    Giancarlo Agnelli
    Division of Internal Medicine and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Ital Heart J 6:824-9. 2005
  3. doi request reprint Oral apixaban for the treatment of acute venous thromboembolism
    Giancarlo Agnelli
    Internal and Cardiovascular Medicine Stroke Unit, University of Perugia, Perugia, Italy
    N Engl J Med 369:799-808. 2013
  4. doi request reprint Apixaban for extended treatment of venous thromboembolism
    Giancarlo Agnelli
    Department of Internal and Cardiovascular Medicine Stroke Unit, University of Perugia, Perugia, Italy
    N Engl J Med 368:699-708. 2013
  5. doi request reprint Semuloparin for thromboprophylaxis in patients receiving chemotherapy for cancer
    Giancarlo Agnelli
    Division of Internal and Cardiovascular Medicine and Stroke Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy
    N Engl J Med 366:601-9. 2012
  6. pmc Chemotherapy-associated thromboembolic risk in cancer outpatients and effect of nadroparin thromboprophylaxis: results of a retrospective analysis of the PROTECHT study
    Sandro Barni
    Oncology Department, San Filippo Neri Hospital, Via Martinotti 20, Rome, 00135, Italy
    J Transl Med 9:179. 2011
  7. ncbi request reprint Venous thromboembolism and atherosclerosis: common denominators or different diseases?
    G Agnelli
    Department of Internal Medicine, Division of Internal and Cardiovascular Medicine and Stroke Unit, University of Perugia, Perugia, Italy
    J Thromb Haemost 4:1886-90. 2006
  8. ncbi request reprint Current issues in anticoagulation
    Giancarlo Agnelli
    Stroke Unit and Cardiovascular Medicine, University of Perugia, Via Enrico Dal Pozzo, IT 06123 Perugia, Italy
    Pathophysiol Haemost Thromb 34:2-9. 2005
  9. ncbi request reprint Duration of anticoagulant treatment after venous thromboembolism
    Cecilia Becattini
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Pathophysiol Haemost Thromb 33:354-7. 2003
  10. ncbi request reprint Spiral computed tomography is the first-line chest imaging test for acute pulmonary embolism: no
    P W Kamphuisen
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    J Thromb Haemost 3:11-3. 2005

Collaborators

Detail Information

Publications129 found, 100 shown here

  1. ncbi request reprint Unresolved issues in the prevention and treatment of venous thromboembolism
    Giancarlo Agnelli
    University of Perugia, Perugia, Italy
    Semin Thromb Hemost 28:33-40. 2002
    ..Clinical trials have begun to investigate many of these issues, and the resulting data have already contributed to improving the management of patients with a high risk of VTE...
  2. ncbi request reprint Long-term therapy of pulmonary embolism
    Giancarlo Agnelli
    Division of Internal Medicine and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Ital Heart J 6:824-9. 2005
    ..Due to the limitations of the currently available oral anticoagulant agents, search for the optimal agent to be used in the long-term treatment of pulmonary embolism is still open...
  3. doi request reprint Oral apixaban for the treatment of acute venous thromboembolism
    Giancarlo Agnelli
    Internal and Cardiovascular Medicine Stroke Unit, University of Perugia, Perugia, Italy
    N Engl J Med 369:799-808. 2013
    ..Apixaban, an oral factor Xa inhibitor administered in fixed doses, may simplify the treatment of venous thromboembolism...
  4. doi request reprint Apixaban for extended treatment of venous thromboembolism
    Giancarlo Agnelli
    Department of Internal and Cardiovascular Medicine Stroke Unit, University of Perugia, Perugia, Italy
    N Engl J Med 368:699-708. 2013
    ..Apixaban, an oral factor Xa inhibitor that can be administered in a simple, fixed-dose regimen, may be an option for the extended treatment of venous thromboembolism...
  5. doi request reprint Semuloparin for thromboprophylaxis in patients receiving chemotherapy for cancer
    Giancarlo Agnelli
    Division of Internal and Cardiovascular Medicine and Stroke Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy
    N Engl J Med 366:601-9. 2012
    ..Patients receiving chemotherapy for cancer are at increased risk for venous thromboembolism. Limited data support the clinical benefit of antithrombotic prophylaxis...
  6. pmc Chemotherapy-associated thromboembolic risk in cancer outpatients and effect of nadroparin thromboprophylaxis: results of a retrospective analysis of the PROTECHT study
    Sandro Barni
    Oncology Department, San Filippo Neri Hospital, Via Martinotti 20, Rome, 00135, Italy
    J Transl Med 9:179. 2011
    ..The aims of this retrospective analysis were to evaluate the thromboembolic risk and the benefit of thromboprophylaxis according to type of chemotherapy...
  7. ncbi request reprint Venous thromboembolism and atherosclerosis: common denominators or different diseases?
    G Agnelli
    Department of Internal Medicine, Division of Internal and Cardiovascular Medicine and Stroke Unit, University of Perugia, Perugia, Italy
    J Thromb Haemost 4:1886-90. 2006
  8. ncbi request reprint Current issues in anticoagulation
    Giancarlo Agnelli
    Stroke Unit and Cardiovascular Medicine, University of Perugia, Via Enrico Dal Pozzo, IT 06123 Perugia, Italy
    Pathophysiol Haemost Thromb 34:2-9. 2005
    ....
  9. ncbi request reprint Duration of anticoagulant treatment after venous thromboembolism
    Cecilia Becattini
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Pathophysiol Haemost Thromb 33:354-7. 2003
  10. ncbi request reprint Spiral computed tomography is the first-line chest imaging test for acute pulmonary embolism: no
    P W Kamphuisen
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    J Thromb Haemost 3:11-3. 2005
  11. ncbi request reprint Is antithrombotic prophylaxis required in cancer patients with central venous catheters? No
    G Agnelli
    Department of Internal Medicine, Division of Internal and Vascular Medicine, Stroke Unit, University of Perugia, Italy
    J Thromb Haemost 4:14-5. 2006
  12. ncbi request reprint Prevention of venous thromboembolism in surgical patients
    Giancarlo Agnelli
    Stroke Unit and Division of Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Italy
    Circulation 110:IV4-12. 2004
    ....
  13. ncbi request reprint Clinical potential of oral direct thrombin inhibitors in the prevention and treatment of venous thromboembolism
    Giancarlo Agnelli
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Drugs 64:47-52. 2004
    ..Oral direct thrombin inhibitors have a promising role in the management of venous thromboembolism and other associated medical conditions...
  14. ncbi request reprint The MASTER registry on venous thromboembolism: description of the study cohort
    Giancarlo Agnelli
    Division of Internal and Cardiovascular Medicine Stroke Unit, University of Perugia, Via Gerardo Dottori, 06100, Perugia, Italy
    Thromb Res 121:605-10. 2008
    ..The aim of this multicenter registry (MASTER) was to prospectively collect data on the epidemiology and long-term clinical outcome of VTE in an unselected cohort of patients...
  15. doi request reprint Thromboprophylaxis during chemotherapy in patients with advanced cancer
    Giancarlo Agnelli
    Internal and Cardiovascular Medicine Stroke Unit, University of Perugia, Perugia, Italy
    Thromb Res 125:S17-20. 2010
    ..In future studies the clinical benefit of antithrombotic prophylaxis should be evaluated in cancer patients at particularly high risk for thromboembolism...
  16. doi request reprint Nadroparin for the prevention of thromboembolic events in ambulatory patients with metastatic or locally advanced solid cancer receiving chemotherapy: a randomised, placebo-controlled, double-blind study
    Giancarlo Agnelli
    Internal and Vascular Medicine Stroke Unit, University of Perugia, Perugia, Italy
    Lancet Oncol 10:943-9. 2009
    ..We did a trial to assess the clinical benefit of the low-molecular-weight heparin nadroparin for the prophylaxis of thromboembolic events in ambulatory patients receiving chemotherapy for metastatic or locally advanced solid cancer...
  17. ncbi request reprint Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study
    Giancarlo Agnelli
    Division of Internal and Cardiovascular Medicine, University of Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Circulation 116:180-7. 2007
    ..Rivaroxaban (BAY 59-7939) is an oral direct factor Xa inhibitor currently under clinical development...
  18. ncbi request reprint Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high-risk abdominal surgery
    G Agnelli
    Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
    Br J Surg 92:1212-20. 2005
    ....
  19. ncbi request reprint The prophylaxis of venous thrombosis in patients with cancer undergoing major abdominal surgery: emerging options
    Giancarlo Agnelli
    Stroke Unit and Cardiovascular Medicine, University of Perugia, Perugia, Italy
    J Surg Oncol 96:265-72. 2007
    ..Recent data suggest that Factor Xa inhibitors are safe and effective for VTE prevention in patients with cancer undergoing abdominal surgery. Further study in this patient population is warranted...
  20. ncbi request reprint Therapy Insight: venous-catheter-related thrombosis in cancer patients
    Giancarlo Agnelli
    Internal Medicine, University of Perugia, Italy
    Nat Clin Pract Oncol 3:214-22. 2006
    ..The recommended treatment for CVC-related thrombosis is based on long-term anticoagulant therapy, with or without catheter removal...
  21. ncbi request reprint A phase II study of the oral factor Xa inhibitor LY517717 for the prevention of venous thromboembolism after hip or knee replacement
    G Agnelli
    Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
    J Thromb Haemost 5:746-53. 2007
    ..LY517717 is an oral direct inhibitor of activated factor X that is currently under clinical development...
  22. pmc A clinical outcome-based prospective study on venous thromboembolism after cancer surgery: the @RISTOS project
    Giancarlo Agnelli
    Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
    Ann Surg 243:89-95. 2006
    ..However, the clinical relevance of asymptomatic venography-detected DVT is unclear, and the population of these clinical trials is not necessarily representative of the overall cancer surgery population...
  23. ncbi request reprint Direct thrombin inhibitors for the prevention of venous thromboembolism after major orthopaedic surgery
    Giancarlo Agnelli
    Stroke Unit and Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Italy
    Curr Pharm Des 11:3885-91. 2005
    ....
  24. ncbi request reprint Epidemiology of cerebral vein and sinus thrombosis
    Giancarlo Agnelli
    Stroke Unit and Division of Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Via Dottori, Sant Andrea delle Fratte, Perugia, Italy
    Front Neurol Neurosci 23:16-22. 2008
    ..Although recognized for more than 100 years, its incidence has been underestimated in the past due to the lack of accurate diagnostic techniques...
  25. ncbi request reprint New anticoagulants
    Giancarlo Agnelli
    Internal and Cardiovascular Medicine and Stroke Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Semin Thromb Hemost 32:793-802. 2006
    ..Some of them have been approved for clinical use, others are in advanced phase of clinical development, and some are still in the initial phase of investigation...
  26. ncbi request reprint Long-term low-dose warfarin use is effective in the prevention of recurrent venous thromboembolism: no
    G Agnelli
    Sezione di Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, Universita di Perugia, Perugia, Italy
    J Thromb Haemost 2:1038-40. 2004
  27. ncbi request reprint Extended oral anticoagulant therapy after a first episode of pulmonary embolism
    Giancarlo Agnelli
    Sezione di Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, Universita di Perugia, Via Enrico Dal Pozzo, 06123 Perugia, Italy
    Ann Intern Med 139:19-25. 2003
    ..The optimal duration of oral anticoagulant treatment after a first episode of pulmonary embolism remains uncertain...
  28. ncbi request reprint Low-molecular-weight heparins in the management of unstable angina
    G Agnelli
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Italy
    Haemostasis 30:158-67; discussion 146-7. 2000
    ..Additionally, LMWHs can be used as a 'bridge' to revascularization in patients for whom early invasive treatment is not readily available...
  29. ncbi request reprint Perspectives on antithrombotic agents: from unfractionated heparin to new antithrombotics
    Giancarlo Agnelli
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via Enrico Dal Pozzo, 06126 Perugia, Italy
    Haematologica 87:757-70. 2002
    ..However, UFH has some limitations such as the need for parenteral administration and close monitoring of its anticoagulant effect. UFH is also associated with bleeding, heparin-induced thrombocytopenia and osteoporosis...
  30. doi request reprint Management of venous thromboembolism in patients with cancer
    G Agnelli
    Internal and Cardiovascular Medicine, Stroke Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy
    J Thromb Haemost 9:316-24. 2011
    ..The long-term treatment of cancer-related VTE is based on therapeutic doses of LMWH in preference to warfarin. The optimal duration of antithrombotic treatment in cancer patients remains to be fully defined...
  31. ncbi request reprint Thrombolysis vs heparin in the treatment of pulmonary embolism: a clinical outcome-based meta-analysis
    Giancarlo Agnelli
    Sezione di Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, Universita degli Studi di Perugia, Via Enrico Dal Pozzo, I 06123 Perugia, Italy
    Arch Intern Med 162:2537-41. 2002
    ..Whether this advantage results in an improved clinical outcome is unclear. We sought to perform a clinical outcome-based meta-analysis of studies comparing thrombolytic and heparin treatment in patients with pulmonary embolism...
  32. ncbi request reprint Thromboprophylaxis during chemotherapy after advanced cancer
    Giancarlo Agnelli
    Division of Internal and Cardiovascular Medicine, Stroke Unit, University of Perugia, Perugia, Italy
    Thromb Res 120:S128-32. 2007
    ....
  33. ncbi request reprint Building effective prophylaxis of deep vein thrombosis in the outpatient setting
    G Agnelli
    Institute of Internal and Vascular Medicine, University of Perugia, Italy
    Blood Coagul Fibrinolysis 10:S29-35. 1999
    ..Due to the high costs of treating thromboembolic complications and post-thrombotic syndrome, appropriately targeted prolonged thromboprophylaxis may be cost-effective...
  34. ncbi request reprint Prevention of venous thromboembolism
    G Agnelli
    Dipartimento di Medicina Interna, Sezione di Medicina Interna e Cardiovascolare, Universita di Perugia, Italy
    Thromb Res 97:V49-62. 2000
    ..Prophylactic methods include pharmacological agents, such as heparin, low molecular weight heparins, warfarin, and hirudin, as well as mechanical methods such as compression stockings and intermittent pneumatic compression...
  35. ncbi request reprint Three months versus one year of oral anticoagulant therapy for idiopathic deep venous thrombosis. Warfarin Optimal Duration Italian Trial Investigators
    G Agnelli
    Dipartimento di Medicina Interna, Universita di Perugia, Italy
    N Engl J Med 345:165-9. 2001
    ..Whether this benefit persists after anticoagulant therapy is discontinued is controversial...
  36. ncbi request reprint Treatment of DVT: how long is enough and how do you predict recurrence
    Giancarlo Agnelli
    Division of Internal and Cardiovascular Medicine, University of Perugia, Via G Dottori 1, Perugia, Italy
    J Thromb Thrombolysis 25:37-44. 2008
    ..At the end of this treatment period physicians should decide for definitive withdrawal or indefinite anticoagulation with scheduled periodic re-assessment of the benefit from extending anticoagulation...
  37. ncbi request reprint Low ankle-brachial index predicts an adverse 1-year outcome after acute coronary and cerebrovascular events
    G Agnelli
    Medicina Interna e Cardiovascolare and Stroke Unit, Dipartimento di Medicina Interna, Universita di Perugia, Perugia, Italy
    J Thromb Haemost 4:2599-606. 2006
    ..The aim of this study was to correlate ABI value (normal or low) with 1-year clinical outcome in patients hospitalized for acute coronary syndromes or cerebrovascular diseases (CVD)...
  38. ncbi request reprint Incidence of cancer after a first episode of idiopathic venous thromboembolism treated with 3 months or 1 year of oral anticoagulation
    M R Taliani
    Sezione di Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, Universita di Perugia, Perugia, Italy
    J Thromb Haemost 1:1730-3. 2003
    ..A prolonged treatment with oral anticoagulants has been claimed to reduce the incidence of newly diagnosed cancer in the long-term follow-up of patients with venous thromboembolism...
  39. ncbi request reprint Prior use of antithrombotic agents and neurological functional outcome at discharge in patients with ischemic stroke
    M Paciaroni
    Stroke Unit and Division of Internal and Cardiovascular Medicine, University of Perugia, Italy
    J Thromb Haemost 4:1957-61. 2006
    ..The aim of this study was to analyze the effect of prior use of antithrombotic agents (antiplatelets or anticoagulants) on neurological functional outcome in patients with acute ischemic stroke...
  40. doi request reprint Efficacy and safety of anticoagulants in the prevention of venous thromboembolism in patients with acute cerebral hemorrhage: a meta-analysis of controlled studies
    M Paciaroni
    Stroke Unit, Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy
    J Thromb Haemost 9:893-8. 2011
    ..We performed an updated meta-analysis of studies to obtain the best estimates of the efficacy and safety of anticoagulants for the prevention of venous thromboembolism in patients with acute hemorrhagic stroke...
  41. doi request reprint Risk factors for upper limb deep vein thrombosis associated with the use of central vein catheter in cancer patients
    Melina Verso
    Dipartimento di Medicina Interna, Universita di Perugia, Perugia, Italy
    Intern Emerg Med 3:117-22. 2008
    ..Patients with distant metastases have an increased risk for thrombosis in absence of antithrombotic prophylaxis...
  42. doi request reprint Safety assessment of new antithrombotic agents: lessons from the EXTEND study on ximelagatran
    G Agnelli
    Division of Internal and Vascular Medicine Stroke Unit, University of Perugia, Perugia, Italy
    Thromb Res 123:488-97. 2009
    ..Ximelagatran, the first oral direct thrombin inhibitor, was shown to be an effective antithrombotic agent but was associated with potential liver toxicity after prolonged administration...
  43. ncbi request reprint Low-molecular-weight and unfractionated heparin for prevention of venous thromboembolism in neurosurgery: a meta-analysis
    A Iorio
    Laboratorio di Analisi Chimico Cliniche, Azienda Ospedaliera Santa Maria Nuova, Reggio Emilia, Perugia, Italy
    Arch Intern Med 160:2327-32. 2000
    ..We performed a meta-analysis of controlled randomized trials on the efficacy and safety of heparin in the prophylaxis of venous thromboembolism in neurosurgery...
  44. pmc Isolated monoparesis following stroke
    M Paciaroni
    Stroke Unit, Department of Neuroscience, University of Perugia, Via Enrico Dal Pozzo, 06126 Perugia, Italy
    J Neurol Neurosurg Psychiatry 76:805-7. 2005
    ..Some investigators have stated that monoparesis is almost never the result of a lacunar infarct or cerebral haemorrhage...
  45. ncbi request reprint Early admission to stroke unit influences clinical outcome
    G Silvestrelli
    Neuroscience, University of Perugia, Perugia, Italy
    Eur J Neurol 13:250-5. 2006
    ..8%). Old age, history of TIA, cardioembolic etiology, severity of neurological deficit and hemorrhagic stroke type all led to earlier arrival time. Admission within 3 hours 'per se' improves outcome and reduced disability at three months...
  46. ncbi request reprint Effect of on-admission antiplatelet treatment on patients with cerebral hemorrhage
    Valeria Caso
    Stroke Unit, Ospedale Santa Maria della Misericordia, San Andrea delle Fratte, Perugia, Italy
    Cerebrovasc Dis 24:215-8. 2007
    ..The aim of this study was to assess the influence of antiplatelet treatment on clinical outcome at hospital discharge...
  47. ncbi request reprint What is the optimal pharmacological prophylaxis for the prevention of deep-vein thrombosis and pulmonary embolism in patients with acute ischemic stroke?
    Pieter W Kamphuisen
    Stroke Unit and Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
    Thromb Res 119:265-74. 2007
    ..We evaluated the benefit/risk ratio of different anticoagulant regimens in the prevention of VTE in patients with AIS...
  48. ncbi request reprint [Prevention of venous thromboembolism in orthopedic surgery and traumatology]
    Giancarlo Agnelli
    Dipartimento di Medicina Interna, Universita di Perugia
    Recenti Prog Med 98:25S-32S. 2007
  49. ncbi request reprint Venous thromboembolism associated with long-term use of central venous catheters in cancer patients
    Melina Verso
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    J Clin Oncol 21:3665-75. 2003
    ..This review focuses on the epidemiology, pathogenesis, diagnosis, prevention, and treatment of VTE in cancer patients with long-term CVC...
  50. ncbi request reprint Clinical and economic aspects of managing venous thromboembolism in the outpatient setting
    G Agnelli
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Semin Hematol 38:58-66. 2001
    ....
  51. ncbi request reprint Prevention of venous thromboembolism after acute ischemic stroke
    P W Kamphuisen
    Stroke Unit and Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
    J Thromb Haemost 3:1187-94. 2005
    ..Both aspirin and mechanical prophylaxis are suboptimal to prevent VTE. Graduated compression stockings should be reserved to patients with a clear contraindication to antithrombotic agents...
  52. ncbi request reprint Fibrinogenolysis and thrombin generation after reduced dose bolus or conventional rt-PA for pulmonary embolism. The Coagulation Project Investigators of the Bolus Alteplase Pulmonary Embolism Group
    G Agnelli
    Istituto di Medicina Interna e Medicina Vascolare, Universita di Perugia, Italy
    Blood Coagul Fibrinolysis 8:216-22. 1997
    ..0%) in Group B suffered major or other important bleeding. Our results indicate that the administration of weight-adjusted reduced-dose rt-PA bolus produces less impairment of blood coagulation than the FDA approved regimen...
  53. ncbi request reprint Outcome in patients with stroke associated with internal carotid artery occlusion
    Maurizio Paciaroni
    Stroke Unit, Department of Neuroscience, University of Perugia, Ospedale Silvestrini, Perugia, Italy
    Cerebrovasc Dis 20:108-13. 2005
    ..The purposes of this study were (1) to assess the predictive factors of adverse outcome in patients with stroke associated with an occlusion of the ICA and (2) to evaluate the rate of spontaneous recanalization of an occluded ICA...
  54. doi request reprint Incidence of arterial cardiovascular events after venous thromboembolism: a systematic review and a meta-analysis
    C Becattini
    Division of Internal and Cardiovascular Medicine and Stroke Unit, University of Perugia, Varese, Italy
    J Thromb Haemost 8:891-7. 2010
    ..Whether patients with unprovoked venous thromboembolism (VTE) have a higher risk of arterial cardiovascular events than the general population and patients with provoked VTE is a matter of debate...
  55. doi request reprint Cryptogenic stroke: time to determine aetiology
    F Guercini
    Stroke Unit and Division of Cardiovascular Medicine, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy
    J Thromb Haemost 6:549-54. 2008
    ..In this review, we discuss new evidence on the aetiology of cryptogenic stroke, specifically focusing on patients with patent foramen ovale and atheroma of the aortic arch...
  56. ncbi request reprint Are placebo-controlled trials ethical in areas where current guidelines recommend therapy? No
    A Iorio
    Division of Internal and Cardiovascular Medicine and Stroke Unit, University of Perugia, Italy
    J Thromb Haemost 4:2133-6. 2006
  57. ncbi request reprint Atrial fibrillation in patients with first-ever stroke: frequency, antithrombotic treatment before the event and effect on clinical outcome
    M Paciaroni
    Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy
    J Thromb Haemost 3:1218-23. 2005
    ....
  58. ncbi request reprint Initial treatment of venous thromboembolism
    Cecilia Becattini
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Italy
    Thromb Haemost 96:242-50. 2006
    ..An oral anticoagulant agent to be used without laboratory monitoring for both acute and long-term treatment of VTE remains an unsolved clinical need in the treatment of VTE...
  59. ncbi request reprint Postoperative pulmonary embolism detected with multislice computed tomography in lung surgery for cancer
    Giuliano Daddi
    Thoracic Surgery Unit, Perugia University, Perugia, Italy
    J Thorac Cardiovasc Surg 132:197-8. 2006
  60. doi request reprint Need for extensive diagnostic work-up for patients with lacunar stroke
    Sara Micheli
    Stroke Unit, Dept of Cardiovascular Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, Sant Andrea delle Fratte, 06128 Perugia, Italy
    J Neurol 255:637-42. 2008
    ..The aims of this study were to evaluate: 1) alternative causes of lacunar stroke other than small-vessel disease; 2) functional outcome of lacunar strokes due to small vessel disease compared to lacunar strokes due to alternative causes...
  61. ncbi request reprint Incidence of chronic thromboembolic pulmonary hypertension after a first episode of pulmonary embolism
    Cecilia Becattini
    Dipartimento di Medicina Interna, Medicina Interna e Cardiovascolare, Universita di Perugia, Via G Dottori, Ospedale Silvestrini, 06129 Perugia, Italy
    Chest 130:172-5. 2006
    ..To assess the incidence of chronic thromboembolic pulmonary hypertension (CTPH) after the first episode of objectively confirmed pulmonary embolism (PE)...
  62. ncbi request reprint Acute pulmonary embolism: risk stratification in the emergency department
    C Becattini
    Sezione di Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, Universita di Perugia, Via G Dottori 1, I 06129, Perugia, Italy
    Intern Emerg Med 2:119-29. 2007
    ..These patients could afford the trade-off of an increased risk of side effects related to a more aggressive treatment, such as thrombolysis or surgical or interventional procedures...
  63. ncbi request reprint Venous thromboembolism and cancer: a two-way clinical association
    G Agnelli
    Istituto di Medicina Interna a Medicina Vasoolare, Universita di Perugia, Italy
    Thromb Haemost 78:117-20. 1997
    ..A multicentre study aimed at investigating this fascinating hypothesis is now being carried out...
  64. ncbi request reprint Statins and stroke prevention
    Maurizio Paciaroni
    Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy
    Cerebrovasc Dis 24:170-82. 2007
    ..87, 95% CI = 0.75-1.01, p = 0.07) and a significant difference in the occurrence of major vascular events (OR = 0.78, 95% CI = 0.68-0.88, p = 0.0001) at final follow-up...
  65. doi request reprint Diagnosis and prognosis of acute pulmonary embolism: focus on serum troponins
    Cecilia Becattini
    Dipartimento di Medicina Interna, Medicina Interna e Cardiovascolare, Stroke Unit, Universita di Perugia, Perugia, Italy
    Expert Rev Mol Diagn 8:339-49. 2008
    ..Elevated serum levels of troponins are associated with right ventricular overload and adverse in-hospital outcomes in patients with pulmonary embolism and normal blood pressure...
  66. ncbi request reprint A prospective study on cardiovascular events after acute pulmonary embolism
    Cecilia Becattini
    Sezione di Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, Universita di Perugia, Via Enrico Dal Pozzo, 06126 Perugia, Italy
    Eur Heart J 26:77-83. 2005
    ..To evaluate the incidence of cardiovascular events in the long-term clinical course of patients with a first episode of symptomatic, objectively confirmed pulmonary embolism...
  67. doi request reprint Clinical benefit of early anticoagulation in cardioembolic stroke
    Sara Micheli
    Stroke Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Cerebrovasc Dis 25:289-96. 2008
    ..A common clinical dilemma in patients with acute stroke is whether the detection of one of the major cardiac sources of emboli requires an early anticoagulation to reduce early stroke recurrence and mortality...
  68. ncbi request reprint Prognostic value of troponins in acute pulmonary embolism: a meta-analysis
    Cecilia Becattini
    Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, University of Perugia, Via G Dottori 1, 06129 Perugia, Italy
    Circulation 116:427-33. 2007
    ..Whether elevated serum troponin levels identify patients with acute pulmonary embolism at high risk of short-term mortality or adverse outcome is undefined...
  69. doi request reprint Gender differences in patients with acute ischemic stroke
    Valeria Caso
    Stroke Unit, Division of Cardiovascular Medicine, University of Perugia, Italy
    Womens Health (Lond Engl) 6:51-7. 2010
    ..In addition, both genders demonstrated different stroke pathophysiologies. These findings should be taken into account when diagnostic workup and treatment are being planned...
  70. doi request reprint Early hemorrhagic transformation of brain infarction: rate, predictive factors, and influence on clinical outcome: results of a prospective multicenter study
    Maurizio Paciaroni
    Stroke Unit, Division of Cardiovascular Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Sant Andrea delle Fratte, Perugia, 06126 Italy
    Stroke 39:2249-56. 2008
    ..The aims of this study were to assess: (1) the rate of early HT in patients admitted for ischemic stroke, (2) the correlation between early HT and functional outcome at 3 months, and (3) the risk factors for early HT...
  71. doi request reprint Risk factors for cerebral ischemic events in patients with atrial fibrillation on warfarin for stroke prevention
    Maurizio Paciaroni
    Stroke Unit, Division of Cardiovascular Medicine, University of Perugia, UO Gravi Cerebrolesioni, S Giovanni Battista Hospital, Foligno, Perugia, Italy
    Atherosclerosis 212:564-6. 2010
    ..The aim of this study was to evaluate the risk factors for cerebral ischemic events in warfarin-treated AF patients with an International Normalized Ratios (INR) above 1.8 on admission...
  72. pmc New anticoagulants for the prevention of venous thromboembolism
    Cecilia Becattini
    Internal and Cardiovascular, Medicine and Stroke Unit, University of Perugia, Italy
    Drug Des Devel Ther 4:49-60. 2010
    ..Differences in pharmacokinetics and pharmacodynamics could offer the potential for individualized anticoagulant therapies in the near future...
  73. doi request reprint Bosentan for chronic thromboembolic pulmonary hypertension: findings from a systematic review and meta-analysis
    Cecilia Becattini
    Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Thromb Res 126:e51-6. 2010
    ..We performed a systematic review and meta-analysis aimed at assessing the effects of bosentan therapy in patients with CTEPH...
  74. ncbi request reprint Enoxaparin for the prevention of venous thromboembolism associated with central vein catheter: a double-blind, placebo-controlled, randomized study in cancer patients
    Melina Verso
    Sezione di Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, Universita di Perugia, Via Enrico Dal Pozzo, 06123 Perugia, Italy
    J Clin Oncol 23:4057-62. 2005
    ..The aim of this study was to evaluate the efficacy and safety of the low molecular weight heparin, enoxaparin, in the prevention of VTE...
  75. doi request reprint Acute hyperglycemia and early hemorrhagic transformation in ischemic stroke
    Maurizio Paciaroni
    Stroke Unit, University of Perugia, Perugia, Italy
    Cerebrovasc Dis 28:119-23. 2009
    ..The aim of this study was to assess whether the admission blood glucose level is related to HT in a prospective study in consecutive patients with acute ischemic stroke...
  76. ncbi request reprint Thrombophilic abnormalities and recurrence of venous thromboembolism in patients treated with standardized anticoagulant treatment
    Maria Gabriella Santamaria
    Sezione di Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, Universita di Perugia, Via Enrico Dal Pozzo, 06123 Perugia, Italy
    Thromb Res 116:301-6. 2005
    ..The aim of this study was to evaluate the incidence of recurrence of venous thromboembolism in patients with and without thrombophilic abnormalities treated with standardized anticoagulant treatment...
  77. doi request reprint Effect of carotid stenosis on the prognostic value of admission blood pressure in patients with acute ischemic stroke
    Maurizio Paciaroni
    Stroke Unit, University of Perugia, Italy
    Atherosclerosis 206:469-73. 2009
    ....
  78. ncbi request reprint Complications of chronic venous access devices in cancer patients
    Giancarlo Agnelli
    University of Perugia, Italy
    Clin Adv Hematol Oncol 1:714-5. 2003
  79. doi request reprint The concept of ischemic penumbra in acute stroke and therapeutic opportunities
    Maurizio Paciaroni
    Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy
    Eur Neurol 61:321-30. 2009
    ..The purpose of this review was to describe neuroimaging modalities capable of identifying penumbra tissue so as to provide surrogate markers for new trials in acute ischemic stroke patients...
  80. doi request reprint Bolus tenecteplase for right ventricle dysfunction in hemodynamically stable patients with pulmonary embolism
    Cecilia Becattini
    Medicina Interna e Cardiovascolare Stroke Unit, Universita di Perugia, Perugia, Italy
    Thromb Res 125:e82-6. 2010
    ..In these patients bolus tenecteplase has the potential to provide an effective and safe thrombolysis...
  81. ncbi request reprint Efficacy of thrombolytic (rt-PA) therapy in old stroke patients: the Perugia Stroke Unit experience
    Lucilla Parnetti
    Stroke Unit, Department of Neuroscience, University of Perugia, Perugia, Italy
    Clin Exp Hypertens 28:397-404. 2006
    ..Age did not influence prognosis in patients treated with rt-PA. The oldest stroke patients should not be excluded from rt-PA treatment on the basis of age per se...
  82. ncbi request reprint [Determinants of prognosis in acute pulmonary embolism: the role of serum troponins]
    Cecilia Becattini
    Medicina Interna e Cardiovascolare, Universita, Perugia
    Recenti Prog Med 99:509-15. 2008
    ..Future studies will evaluate the clinical benefit of thrombolytic treatment in hemodynamically stable patients with acute pulmonary embolism at high risk for adverse outcome...
  83. ncbi request reprint Novel approaches to the treatment of thrombosis
    Paolo Gresele
    Division of Internal and Cardiovascular Medicine, Dept of Internal Medicine, University of Perugia, Via E dal Pozzo, I 06126, Perugia, Italy
    Trends Pharmacol Sci 23:25-32. 2002
    ..Several achievements are anticipated from the development of new antithrombotics, including a further reduction of cardiovascular mortality and unwanted bleeding, and easier patient management...
  84. doi request reprint Risk of recurrent cerebrovascular events in patients with cryptogenic stroke or transient ischemic attack and patent foramen ovale: the FORI (Foramen Ovale Registro Italiano) study
    Maurizio Paciaroni
    Stroke Unit, Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy
    Cerebrovasc Dis 31:109-16. 2011
    ....
  85. ncbi request reprint Hormone-replacement therapy, dementia and stroke
    Amr Billeci
    University of Perugia, Stroke Unit and Division of Cardiovascular Medicine, Ospedale SM della Misericordia, Sant Andrea delle Fratte, 06129 Perugia, Italy
    Womens Health (Lond Engl) 3:699-710. 2007
    ..Here, the data from the most important studies are examined, concluding that HRT has no beneficial effect on dementia or stroke risk reduction in postmenopausal women...
  86. pmc Management of asymptomatic carotid stenosis in patients undergoing general and vascular surgical procedures
    M Paciaroni
    Stroke Unit, University of Perugia, Ospedale Silvestrini, Sant Andrea delle Fratte, Perugia 06126, Italy
    J Neurol Neurosurg Psychiatry 76:1332-6. 2005
    ..Clarification of the optimal strategy requires an adequately powered, multicentre, randomised clinical trial...
  87. ncbi request reprint Effects of cefamandole on hemostasis in patients undergoing hip replacement with heparin prophylaxis
    G Agnelli
    Institute of Semeiotica Medica, University of Perugia, Italy
    Chemioterapia 7:396-9. 1988
    ..No difference in the surgical bleeding was observed between the two groups. We conclude that a short-term prophylaxis with cefamandole is a safe regimen in patients undergoing hip replacement with heparin prophylaxis...
  88. doi request reprint Combined oral anticoagulants and antiplatelets: benefits and risks
    Maria Cristina Vedovati
    Internal and Cardiovascular Medicine and Stroke Unit, University of Perugia, Perugia, Italy
    Intern Emerg Med 5:281-90. 2010
    ..Thus, a combined regimen of anticoagulant and antiplatelet therapy should be reserved for selected patients at high risk of thromboembolic events who have a low risk of bleeding...
  89. ncbi request reprint Efficacy and safety of anticoagulant treatment in acute cardioembolic stroke: a meta-analysis of randomized controlled trials
    Maurizio Paciaroni
    Stroke Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Stroke 38:423-30. 2007
    ..We performed an updated meta-analysis of all randomized trials to obtain the best estimates of the efficacy and safety of anticoagulants for the initial treatment of acute cardioembolic stroke...
  90. ncbi request reprint Endothelial dysfunction in patients with spontaneous venous thromboembolism
    Rino Migliacci
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Haematologica 92:812-8. 2007
    ..Endothelial dysfunction is an early marker of atherosclerosis and has predictive value for ischemic events. We have evaluated endothelial function in patients with a history of spontaneous venous thromboembolism...
  91. doi request reprint Prognostic role of embolic burden assessed at computed tomography angiography in patients with acute pulmonary embolism: systematic review and meta-analysis
    M C Vedovati
    Department of Internal and Cardiovascular Medicine Stroke Unit, University of Perugia, Perugia, Italy
    J Thromb Haemost 11:2092-102. 2013
    ..Whether embolic burden assessed at computed tomography (CT) angiography has a role in risk stratification in these patients is debated...
  92. doi request reprint To drain or not to drain extraperitoneal colorectal anastomosis? A systematic review and meta-analysis
    F Rondelli
    San Giovanni Battista Hospital, Foligno, Perugia, Italy Department of Surgery, School of Medicine, University of Perugia, Perugia, Italy
    Colorectal Dis 16:O35-42. 2014
    ..Although many studies have compared drained and undrained colorectal anastomoses, to date the role of pelvic drainage in extraperitoneal colorectal anastomosis remains undefined...
  93. ncbi request reprint End points in studies on the prevention of deep vein thrombosis
    F Sonaglia
    Dipartimento di Medicina Interna, , Italy
    Semin Thromb Hemost 27:41-6. 2001
    ..When a new pharmacologic agent is compared with the "gold standard" agent, the use of symptomatic end points should be preferable...
  94. ncbi request reprint Rationale for the use of platelet aggregation inhibitors in PAD patients
    G Agnelli
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Italy
    Vasc Med 6:13-5. 2001
    ..This study showed an 8.7% decrease in the relative risk reduction for further atherothrombotic events with clopidogrel over aspirin (p = 0.043) for the overall population, in terms of the combined endpoint of IS, Ml or vascular death...
  95. ncbi request reprint Risk factors for adverse short-term outcome in patients with pulmonary embolism
    C Becattini
    Sezione di Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, , Perugia, Italy
    Thromb Res 103:V239-44. 2001
    ..However, such treatments are invariably associated with bleeding and other procedural complications...
  96. ncbi request reprint Seizures, headache and thrombocytopenia: diagnosis and treatment do not always come in a standard sequence
    A Iorio
    Medicina Interna e Vascolare Stroke Unit, Dipartimento di Medicina Interna, Ospedale S Maria della Misericordia, Perugia, Italy
    Intern Emerg Med 2:202-6. 2007
  97. ncbi request reprint Prevention of venous thromboembolism in high risk patients
    G Agnelli
    Istituto di Medicina Interna e Medicina Vascolare, Universita di Perugia, Italy
    Haematologica 82:496-502. 1997
    ..Then, the available guidelines for the management of thrombophilic patients will be given...
  98. pmc Early seizures in patients with acute stroke: frequency, predictive factors, and effect on clinical outcome
    Andrea Alberti
    Stroke Unit and Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
    Vasc Health Risk Manag 4:715-20. 2008
    ..The aim of this study was to assess the rate of and the predictive factors for ES as well the effects of ES on the clinical outcome at hospital discharge in patients with first-ever stroke...
  99. ncbi request reprint Activation of blood coagulation in patients undergoing postoperative blood salvage and re-infusion of unwashed whole blood after total knee arthroplasty
    Dino Biagini
    Centro Ortopedico Umbro, Perugia, Italy
    Thromb Res 113:211-5. 2004
    ..Limited information is available on the influence of re-infused whole blood on the hemostatic system in orthopedic patients...
  100. pmc Determinants of outcome in patients eligible for thrombolysis for ischemic stroke
    Valeria Caso
    Stroke Unit, Department of Internal Medicine, Ospedale Silvestrini Perugia, Italy
    Vasc Health Risk Manag 3:749-54. 2007
    ..However, not all eligible patients benefit from this treatment. This study aimed to assess the determinants for clinical outcome in consecutive, eligible patients with ischemic stroke treated with thrombolysis in a single-center study...
  101. ncbi request reprint Pathogenesis of venous thromboembolism
    Cecilia Becattini
    Sezione di Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, Universita di Perugia, Perugia, Italy
    Curr Opin Pulm Med 8:360-4. 2002
    ..Vessel wall has a remarkable role in protecting against and in promoting thrombosis. The role of inflammation on venous thrombosis is under investigation...