Maria P Abbracchio

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. pmc P1 receptors and cytokine secretion
    Maria P Abbracchio
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133, Milan, Italy
    Purinergic Signal 3:13-25. 2007
  2. pmc The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair
    Davide Lecca
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    PLoS ONE 3:e3579. 2008
  3. ncbi request reprint The A3 adenosine receptor induces cytoskeleton rearrangement in human astrocytoma cells via a specific action on Rho proteins
    M P Abbracchio
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Ann N Y Acad Sci 939:63-73. 2001
  4. pmc Roles of P2 receptors in glial cells: focus on astrocytes
    Maria P Abbracchio
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milano, Italy
    Purinergic Signal 2:595-604. 2006
  5. pmc GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors
    Chiara Parravicini
    Laboratory of Cellular and Molecular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    BMC Bioinformatics 9:263. 2008
  6. pmc The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor
    Paolo Ciana
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    EMBO J 25:4615-27. 2006
  7. doi request reprint Expression and contribution of satellite glial cells purinoceptors to pain transmission in sensory ganglia: an update
    Giovanni Villa
    Laboratory of Molecular and Cellular, Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, Italy
    Neuron Glia Biol 6:31-42. 2010
  8. pmc Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation
    Marta Fumagalli
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Biol Chem 286:10593-604. 2011
  9. doi request reprint Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes
    Alessia Mazzola
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Cell Mol Med 12:522-36. 2008
  10. pmc The regulated expression, intracellular trafficking, and membrane recycling of the P2Y-like receptor GPR17 in Oli-neu oligodendroglial cells
    Alessandra Fratangeli
    Consiglio Nazionale delle Ricerche Institute of Neuroscience, Department of Medical Biotechnologies and Translational Medicine, University of Milan, Milan 20129, Italy
    J Biol Chem 288:5241-56. 2013

Collaborators

Detail Information

Publications45

  1. pmc P1 receptors and cytokine secretion
    Maria P Abbracchio
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133, Milan, Italy
    Purinergic Signal 3:13-25. 2007
    ....
  2. pmc The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair
    Davide Lecca
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    PLoS ONE 3:e3579. 2008
    ..Specifically, we suggest GPR17 as a novel target for therapeutic manipulation to foster repair of demyelinating wounds, the types of lesions that also occur in patients with multiple sclerosis...
  3. ncbi request reprint The A3 adenosine receptor induces cytoskeleton rearrangement in human astrocytoma cells via a specific action on Rho proteins
    M P Abbracchio
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Ann N Y Acad Sci 939:63-73. 2001
    ....
  4. pmc Roles of P2 receptors in glial cells: focus on astrocytes
    Maria P Abbracchio
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milano, Italy
    Purinergic Signal 2:595-604. 2006
    ....
  5. pmc GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors
    Chiara Parravicini
    Laboratory of Cellular and Molecular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    BMC Bioinformatics 9:263. 2008
    ..To explore the binding mode of the "purinergic" component of the receptor, the endogenous agonist UDP and two P2Y receptor antagonists demonstrated to be active on GPR17 (MRS2179 and cangrelor) were then modeled on the receptor...
  6. pmc The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor
    Paolo Ciana
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    EMBO J 25:4615-27. 2006
    ..In conclusion, the deorphanization of GPR17 revealed a dualistic receptor for two endogenous unrelated ligand families. These findings may lead to dualistic drugs of previously unexplored therapeutic potential...
  7. doi request reprint Expression and contribution of satellite glial cells purinoceptors to pain transmission in sensory ganglia: an update
    Giovanni Villa
    Laboratory of Molecular and Cellular, Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, Italy
    Neuron Glia Biol 6:31-42. 2010
    ..These findings may have relevant implications for the development of new therapeutic strategies for chronic pain treatment...
  8. pmc Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation
    Marta Fumagalli
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Biol Chem 286:10593-604. 2011
    ..These data have implications for the in vivo behavior of NG2(+) OPCs and point to uracil nucleotides and cysLTs as main extrinsic local regulators of these cells under physiological conditions and during myelin repair...
  9. doi request reprint Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes
    Alessia Mazzola
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Cell Mol Med 12:522-36. 2008
    ..Thus, release of UTP during cardiac ischaemia and in chronic heart failure may protect against myocardial damage, setting the basis for developing novel cardioprotective agents that specifically target uracil-preferring P2Y receptors...
  10. pmc The regulated expression, intracellular trafficking, and membrane recycling of the P2Y-like receptor GPR17 in Oli-neu oligodendroglial cells
    Alessandra Fratangeli
    Consiglio Nazionale delle Ricerche Institute of Neuroscience, Department of Medical Biotechnologies and Translational Medicine, University of Milan, Milan 20129, Italy
    J Biol Chem 288:5241-56. 2013
    ..Our results provide the first data on the agonist-induced trafficking of native GPR17 in oligodendroglial cells and may have implications for both physiological and pathological myelination...
  11. pmc International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy
    Maria P Abbracchio
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Pharmacol Rev 58:281-341. 2006
    ..These and other advances are discussed in the present review...
  12. doi request reprint Expression of the new P2Y-like receptor GPR17 during oligodendrocyte precursor cell maturation regulates sensitivity to ATP-induced death
    Stefania Ceruti
    Department of Pharmacological Sciences, Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Universita degli Studi di Milano, Milan, Italy
    Glia 59:363-78. 2011
    ..This double-edged sword role may be exploited to unveil new therapeutic approaches to acute and chronic brain disorders...
  13. doi request reprint Calcitonin gene-related peptide-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q Cav2.1 Knock-in mice: implications for basic mechanisms of migraine pain
    Stefania Ceruti
    Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Neurosci 31:3638-49. 2011
    ....
  14. ncbi request reprint Proteasome inhibitors potentiate etoposide-induced cell death in human astrocytoma cells bearing a mutated p53 isoform
    Stefania Ceruti
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, School of Pharmacy, University of Milan, Milan, Italy
    J Pharmacol Exp Ther 319:1424-34. 2006
    ..In conclusion, use of etoposide in combination with proteasome inhibitors may represent an effective strategy to restore sensitivity to apoptosis in human astrocytoma cells bearing multiple defects of intracellular apoptotic pathways...
  15. ncbi request reprint A role for P2X7 in microglial proliferation
    Fabio Bianco
    CNR Institute of Neuroscience, Milan, Italy
    J Neurochem 99:745-58. 2006
    ..Overall, our data show that the P2X(7) receptor plays an important role in controlling microglial proliferation by supporting cell cycle progression...
  16. ncbi request reprint The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury
    Stefania Ceruti
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Brain 132:2206-18. 2009
    ..Moreover, its presence on spinal cord pre-oligodendrocytes and precursor-like cells suggests GPR17 as a novel target for therapeutic manipulation to foster remyelination and functional repair in SCI...
  17. ncbi request reprint Purinoceptor-mediated calcium signaling in primary neuron-glia trigeminal cultures
    Stefania Ceruti
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Cell Calcium 43:576-90. 2008
    ..At this exposure time, P2Y receptors responses in satellite glia were instead upregulated, suggesting a complex modulation of P2 receptors in pain signaling...
  18. pmc Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death
    Davide Lecca
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti, 9 Milan, 20133, Italy
    Purinergic Signal 8:539-57. 2012
    ..g., polydendrocytes) and of other cells somehow related to glial cells (e.g., pericytes and spinal cord ependymal cells)...
  19. ncbi request reprint Resistance of human astrocytoma cells to apoptosis induced by mitochondria-damaging agents: possible implications for anticancer therapy
    Stefania Ceruti
    Department of Pharmacological Sciences, Via Balzaretti 9, University of Milan, 20133 Milan, Italy
    J Pharmacol Exp Ther 314:825-37. 2005
    ..These results may have implications for developing strategies aimed at overcoming tumor resistance to chemotherapy...
  20. ncbi request reprint Nucleotide-mediated calcium signaling in rat cortical astrocytes: Role of P2X and P2Y receptors
    Marta Fumagalli
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Glia 43:218-03. 2003
    ..e., P2X(2), P2X(4), P2X(5), P2Y(2), P2Y(4), and P2Y(14)) may also contribute...
  21. ncbi request reprint Pathophysiological roles of extracellular nucleotides in glial cells: differential expression of purinergic receptors in resting and activated microglia
    Fabio Bianco
    Department of Medical Pharmacology, CNR Institute of Neuroscience, Cellular and Molecular Pharmacology, Milan, Italy
    Brain Res Brain Res Rev 48:144-56. 2005
    ....
  22. doi request reprint In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases
    Ivano Eberini
    Gruppo di Studio per la Proteomica e la Struttura delle Proteine, Dipartimento di Scienze Farmacologiche, Universita degli Studi di Milano, Italy
    J Comput Aided Mol Des 25:743-52. 2011
    ..None of these compounds could have been expected 'a priori' to act on a GPCR, and all of them behaved as much more potent ligands than GPR17 endogenous activators...
  23. ncbi request reprint P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFalpha and potential role in myocardial cell death
    Cristina Banfi
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Mol Cell Cardiol 39:929-39. 2005
    ..In conclusion, we provide the first characterization of P2 receptors in the human heart and suggest that the interaction between TNFalpha and the upregulated P2X(6) receptor may represent a novel pathogenic mechanism in CHF...
  24. ncbi request reprint CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation
    Valerie Capra
    Laboratory of Molecular Pharmacology, Section of Eicosanoid Pharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Cell Sci 118:5625-36. 2005
    ..This crosstalk may have a profound physiological implication in the regulation of responses at sites of inflammation, and may represent just an example of a feedback mechanism used by cells to fine-tune their responses...
  25. pmc Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach
    Chiara Parravicini
    Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    BMC Struct Biol 10:8. 2010
    ....
  26. pmc Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus
    Giovanni Villa
    Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Mol Pain 6:89. 2010
    ....
  27. ncbi request reprint Role of purinergic signalling in neuro-immune cells and adult neural progenitors
    Marta Fumagalli
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, Via Balzaretti 9, 20133 Milan, Italy
    Front Biosci (Landmark Ed) 16:2326-41. 2011
    ..Here, we revise the state of the art in this expanding field with the final aim of unveiling whether new purinergic-based therapies may be useful to halt excessive inflammation and foster endogenous repair in neuroinflammatory disorders...
  28. ncbi request reprint Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor
    Marta Fumagalli
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan 20133, Italy
    Biochem Pharmacol 68:113-24. 2004
    ....
  29. doi request reprint Cardiomyocyte death induced by ischaemic/hypoxic stress is differentially affected by distinct purinergic P2 receptors
    Simona Cosentino
    Centro Cardiologico Monzino IRCCS, Milan, Italy
    J Cell Mol Med 16:1074-84. 2012
    ..Overall, these findings indicate a role for ATP and its receptors in modulating cardiomyocyte damage during ischaemic/hypoxic stress...
  30. ncbi request reprint Pathophysiological roles of P2 receptors in glial cells
    Maria P Abbracchio
    Department of Pharmacological Sciences, University of Milan, Italy
    Novartis Found Symp 276:91-103; discussion 103-12, 275-81. 2006
    ..They also open up the possibility of modulating brain damage by ligands selectively targeting the specific P2 receptor subtypes involved in the gliotic response...
  31. doi request reprint Oxygen-glucose deprivation increases the enzymatic activity and the microvesicle-mediated release of ectonucleotidases in the cells composing the blood-brain barrier
    Stefania Ceruti
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti, 9, 20133 Milan, Italy
    Neurochem Int 59:259-71. 2011
    ..This in vitro model is therefore useful to study the role of extracellular nucleotides in modulating BBB responses to ischemic events, and to develop new effective purinergic-based approaches for brain ischemia...
  32. ncbi request reprint Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines
    Paola Massi
    Department of Pharmacology, University of Milan, Milan, Italy
    J Pharmacol Exp Ther 308:838-45. 2004
    ..In conclusion, the nonpsychoactive CBD was able to produce a significant antitumor activity both in vitro and in vivo, thus suggesting a possible application of CBD as an antineoplastic agent...
  33. pmc Microglia is a key player in the reduction of stroke damage promoted by the new antithrombotic agent ticagrelor
    Paolo Gelosa
    Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
    J Cereb Blood Flow Metab 34:979-88. 2014
    ..01). Our results show that ticagrelor is protective against ischemia-induced cerebral injury and this effect is mediated, at least partly, by inhibition of P2Y12-mediated microglia activation and chemotaxis. ..
  34. doi request reprint Adenosine signaling in glioma cells
    Stefania Ceruti
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, 9 Via Balzaretti, 20133, Milan, Italy
    Adv Exp Med Biol 986:13-30. 2013
    ....
  35. ncbi request reprint Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes
    Roberta Brambilla
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Glia 43:190-4. 2003
    ....
  36. ncbi request reprint Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family
    Maria P Abbracchio
    Department of Pharmacological Sciences, University of Milan, Italy
    Trends Pharmacol Sci 24:52-5. 2003
    ..Here, the IUPHAR Subcommittee for P2Y receptor nomenclature and classification review the current knowledge of this receptor and present their reasons for including this receptor in the P2Y receptor family as the P2Y(14) receptor...
  37. doi request reprint Purines regulate adult brain subventricular zone cell functions: contribution of reactive astrocytes
    Marta Boccazzi
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy
    Glia 62:428-39. 2014
    ..Altogether, our results show that the purinergic system crucially affects SVZ progenitor activities both directly and through the involvement of reactive astrocytes...
  38. doi request reprint Using peripheral blood mononuclear cells to determine proteome profiles in human cardiac failure
    Alessia Mazzola
    Department of Pharmacological Sciences, University of Milan, Italy
    Eur J Heart Fail 10:749-57. 2008
    ..In chronic heart failure (CHF), peripheral blood mononuclear cells (PBMC) might undergo structural and/or functional alterations as a consequence of the development and progression of the disease...
  39. ncbi request reprint Early and transient alteration of adenosine A2A receptor signaling in a mouse model of Huntington disease
    Alessia Tarditi
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Neurobiol Dis 23:44-53. 2006
    ..These data, reproducing ex vivo the previous observations in vitro, support the hypothesis that an alteration of A2A receptor signaling is present in HD and might represent an interesting target for neuroprotective therapies...
  40. ncbi request reprint Deorphanisation of G protein-coupled receptors: A tool to provide new insights in nervous system pathophysiology and new targets for psycho-active drugs
    Davide Lecca
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, School of Pharmacy, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Neurochem Int 52:339-51. 2008
    ....
  41. doi request reprint Purinergic signalling in the nervous system: an overview
    Maria P Abbracchio
    Department of Pharmacological Sciences, Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Via Balzaretti 9, University of Milan, 20133 Milan, Italy
    Trends Neurosci 32:19-29. 2009
    ....
  42. ncbi request reprint A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells
    Stefania Ceruti
    University of Milan and Center of Excellence for Neurodegenerative Diseases CEND Via Balzaretti 9, 20133 Milan, Italy
    Mol Pharmacol 63:1437-47. 2003
    ..Therefore, these compounds could be effectively used in the pharmacological manipulation of tumors characterized by resistance to cell death via either the mitochondrial or caspase-8/death receptor pathways...
  43. ncbi request reprint Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling
    Roberta Brambilla
    Department of Pharmacological Sciences, University of Milan School of Pharmacy, Milan, Italy
    J Neurochem 83:1285-96. 2002
    ..Based on the involvement of cyclooxygenase-2 and inflammation in neurodegenerative diseases, these findings open up new avenues in the identification of novel biological targets for the pharmacological manipulation of neurodegeneration...
  44. ncbi request reprint CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors
    Liaman Mamedova
    Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Pharmacol 71:115-25. 2005
    ....
  45. ncbi request reprint The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor
    Maria P Abbracchio
    Trends Pharmacol Sci 26:8-9. 2005