Research Topics
| Pier Luigi PaggiaroSummaryAffiliation: Unit of Pneumology and Allergology Country: Italy Publications
| Collaborators
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Detail Information
Publications
Shuttle walking test and 6-minute walking test induce a similar cardiorespiratory performance in patients recovering from an acute exacerbation of chronic obstructive pulmonary diseaseB Vagaggini
Cardio Thoracic Department, Pneumology Section, University of Pisa, Italy
Respiration 70:579-84. 2003....- Ozone exposure increases eosinophilic airway response induced by previous allergen challengeBarbara Vagaggini
Cardiothoracic Department, Respiratory Pathophysiology Unit, University of Pisa, Pisa, Italy
Am J Respir Crit Care Med 166:1073-7. 2002..This observation may help explain the synergistic effect of air pollution and allergen exposure in the exacerbation of asthma... - Reproducibility of early and late asthmatic responses to allergen challenge in a large group of asthmaticsF L Dente
Cardio Thoracic Department, University of Pisa, Italy
Respir Med 94:441-7. 2000..Moreover, we have demonstrated that the interval between two allergen challenges can determine a change in reproducibility in asthmatic responses induced by allergen challenge... - Sputum inductionP L Paggiaro
Cardiothoracic Dept, Cisanello Hospital, Pisa, Italy
Eur Respir J Suppl 37:3s-8s. 2002 - [Clinical aspects of chronic obstructive pulmonary disease]Pierluigi Paggiaro
Dipartimento Cardio Toracico, Sezione di Pneumologia, Universita degli Studi, Pisa
Ann Ist Super Sanita 39:519-28. 2003..Accurate definition of the heterogeneity of chronic obstructive pulmonary disease can be useful in the prognosis and management of the disease... - Methylprednisolone suleptanate Pharmacia CorpP Paggiaro
University of Pisa Fisiopatologia Respiratoria Ospedale di Cisanello via Paradisa 2 Pisa 56100, Italy
Curr Opin Investig Drugs 1:97-103. 2000..Preclinical studies are also taking place for the potential treatment of spinal cord injury [344254]. In April 2000, Morgan Stanley Dean Witter estimated sales would be US $281 million in 2003, rising to $277 million in 2004 [375906]... 
Magnitude of late asthmatic response to allergen in relation to baseline and allergen-induced sputum eosinophilia in mild asthmatic patientsFederico L Dente
Cardio Thoracic Department, Respiratory Pathophysiology, University Hospital of Pisa, Pisa, Italy
Ann Allergy Asthma Immunol 100:457-62. 2008..Late asthmatic response (LAR) to allergen challenge is a validated method for studying the pathogenesis of and new treatments for asthma in the laboratory...- Analysis of sputum cell counts during spontaneous moderate exacerbations of asthma in comparison to the stable phaseAntonella Di Franco
Cardiothoracic Department, University of Pisa, Pisa, Italy
J Asthma 40:155-62. 2003..Changes in the degree of airway eosinophilic inflammation are related to changes in the severity of airway obstruction during asthma exacerbation... - Inhaled fluticasone propionate is effective as well as oral prednisone in reducing sputum eosinophilia during exacerbations of asthma which do not require hospitalizationAntonella Di Franco
Respiratory Phatophysiology, Cardio Thoracic Department, University of Pisa, Via Paradisa 2, 56214 Pisa, Italy
Pulm Pharmacol Ther 19:353-60. 2006..We conclude that FP is effective at least as well as P in reducing sputum eosinophilia and in improving airway obstruction due to asthma exacerbation. However, the cost/effectiveness ratio of this option should be further evaluated... 
Induced sputum is a reproducible method to assess airway inflammation in asthmaElena Bacci
Cardiothoracic Department, University of Pisa, Italy
Mediators Inflamm 11:293-8. 2002..We conclude that analysis of induced sputum is a reproducible method to study airway inflammation in asthma. Sample sizes greater than ours give little improvement in the detectable difference of eosinophil percentages...- Biological markers in induced sputum of patients with different phenotypes of chronic airway obstructionMaria Laura Bartoli
Cardiothoracic and Vascular Department, University of Pisa, Pisa, Italy
Respiration 77:265-72. 2009.... - Beclomethasone dipropionate blunts allergen-induced early increase in urinary LTE4Maria Laura Bartoli
Cardio Thoracic and Vascular Department, University of Pisa, Pisa, Italy
Eur J Clin Invest 40:566-9. 2010..The aim of this study was to evaluate the effect of CS on allergen-induced increase in urinary leukotriene E4 (uLTE4) during early (EAR) and late (LAR) asthmatic responses in mild untreated asthmatics... - Tiotropium and exercise training in COPD patients: effects on dyspnea and exercise toleranceNicolino Ambrosino
Cardio Thoracic Department, University Hospital, Pisa, Italy
Int J Chron Obstruct Pulmon Dis 3:771-80. 2008..Tiotropium 18 microg once daily induces sustained bronchodilation throughout the day and reduces hyperinflation, one of the pathophysiological factors contributing to exertional dyspnea in COPD patients... - Acute administration of bronchodilators on exercise tolerance in treated COPD patientsBarbara Vagaggini
Cardio Thoracic and Vascular Department, Section of Pneumology, University of Pisa, Italy
Pulm Pharmacol Ther 24:49-54. 2011..In conclusion, although a single-dose BD+ICS did not improve ET in COPD patients under regular treatment, a subgroup of more severe patients may have some benefit from that... - Granulocyte markers in hypertonic and isotonic saline-induced sputum of asthmatic subjectsS Cianchetti
Cardiac and Thoracic Dept, Pneumology Section, Cisanello, Via Paradisa 2, Pisa 56124, Italy
Eur Respir J 24:1018-24. 2004.... - Pattern of airway response to allergen extract of Phleum pratensis in asthmatic patients during and outside the pollen seasonP L Paggiaro
2nd Medical Clinic, University of Pisa, Italy
Respiration 57:51-6. 1990..PD15FEV1 methacholine and baseline FEV1 decreased significantly during the pollen season, but PD15FEV1 allergen did not change significantly during the season.(ABSTRACT TRUNCATED AT 250 WORDS).. - Budesonide reduces neutrophilic but not functional airway response to ozone in mild asthmaticsB Vagaggini
Cardiothoracic Department, Ospedale Cisanello, Pisa, Italy
Am J Respir Crit Care Med 164:2172-6. 2001..05). Therefore, 4 wk of inhaled budesonide blunted the airway neutrophilic inflammatory response but did not prevent the functional impairment of the airways after ozone exposure... - Minimal tolerance to the bronchoprotective effect of inhaled salmeterol/fluticasone combination on allergene challengeP L Paggiaro
Pneumology Section, Dipartimento Cardiotoracico, University of Pisa, Ospedale di Cisanello, Via Paradisa 2, Pisa, Italy
Pulm Pharmacol Ther 19:425-9. 2006..This observation may contribute to explain the positive interaction between inhaled beta2-agonists and corticosteroids in the long-term treatment of asthma... - A computer-based method for on-line acquisition and analysis of bronchial challenge testF Di Pede
2nd Medical Clinic, University of Pisa, Italy
Int J Clin Monit Comput 5:217-20. 1988..In conclusion the computer program is able to reduce consistently the time spent to analyze data from bronchial challenge test and allows a more precise determination of provocative doses by avoiding also inter-intra individual errors... - Natural exposure to pollen reduces the threshold but does not change the pattern of response to the allergen in allergic subjectsF L Dente
Cardio Thoracic Department, University of Pisa, Italy
Respir Med 94:1073-8. 2000..The natural exposure to pollen induces an increase in bronchial sensitivity to allergen in sensitized subjects, but it does not induce LAR in subjects without LAR outside the pollen season... - Some factors influencing quality of spontaneous or induced sputum for inflammatory cell analysisM L Bartoli
Cardiothoracic Department, Respiratory Pathophysiology, University of Pisa, Italy
Monaldi Arch Chest Dis 67:81-3. 2007..To find some simple clinical factors which can predict the quality of the sputum samples obtained in a large group of asthmatic subjects... - Fifty microg b.i.d. of inhaled fluticasone propionate (FP) are effective in stable asthmatics previously treated with a higher dose of FPD Giannini
Cardio-Thoracic Department, University of Pisa, Italy
Respir Med 97:463-7. 2003..i.d.) are effective in maintaining for 3 months a good control of the disease in asthmatics already stable under high-dose fluticasone, considering both clinical and functional outcomes and markers of airway inflammation... - Clinical assessment of asthma severity partially corresponds to sputum eosinophilic airway inflammationM L Bartoli
Cardiothoracic Department, Respiratory Pathophysiology, Ospedale di Cisanello, University of Pisa, Via Paradisa 2, Pisa 56124, Italy
Respir Med 98:184-93. 2004..In conclusion, the assessment of asthma severity according to clinical and functional findings only partially corresponds to the severity of eosinophilic airway inflammation as assessed by induced sputum analysis... - Predictors of symptom recurrence after low-dose inhaled corticosteroid cessation in mild persistent asthmaM Tonelli
Cardiac and Thoracic Department, Respiratory Pathophysiology, University of Pisa, Italy
Respir Med 100:622-9. 2006..In conclusion, age and asthma duration were the best predictors of symptom recurrence in mild persistent asthmatics who withdrew pharmacological therapy, as recommended in the step-down of international guidelines... - One week treatment with salmeterol does not prevent early and late asthmatic responses and sputum eosinophilia induced by allergen challenge in asthmaticsF L Dente
Sezione di Pneumologia, Dipartimento Cardio Toracico, Ospedale di Cisanello, Fisiopatologia Respiratoria Universitaria, Via Paradisa 2, Universita di Pisa, 56100 Pisa, Italy
Pulm Pharmacol Ther 17:147-53. 2004..In conclusion, 1 week treatment with salmeterol causes a loss of its protective effect on allergen-induced airway bronchoconstriction, and does not prevent the subsequent increase in sputum and serum eosinophilic markers... - Quality evaluation of samples obtained by spontaneous or induced sputum: comparison between two methods of processing and relationship with clinical and functional findingsM L Bartoli
Cardiothoracic Department, University of Pisa, Italy
J Asthma 39:479-86. 2002..Sputum quality is only marginally affected by clinical and functional characteristics of asthma, or by asthma severity... - Comparison of anti-inflammatory and clinical effects of beclomethasone dipropionate and salmeterol in moderate asthmaE Bacci
Cardiothoracic Dept, University of Pisa, Cisaneelo Hospital, Italy
Eur Respir J 20:66-72. 2002..Beclomethasone also had an overall greater clinical effect, although the improvement in symptoms and peak expiratory flow variability was similar after both treatments... - Effects of inhaled corticosteroids on cough threshold in patients with bronchial asthmaA Di Franco
Cardio-Thoracic Department, University of Pisa, Italy
Pulm Pharmacol Ther 14:35-40. 2001..These data confirm that cough in asthma can be partially related to airway inflammation... - Diagnosis of flour-induced occupational asthma in a cross-sectional studyD Talini
Cardio-Thoracic Department, Respiratory Pathophysiology, University of Pisa, Italy
Respir Med 96:236-43. 2002..This approach could be relevant for an early diagnosis ofoccupational asthma... - Efficacy of nebulized flunisolide combined with salbutamol and ipratropium bromide in stable patients with moderate-to-severe chronic obstructive pulmonary diseaseP L Paggiaro
Cardiothoracic Department, University of Pisa, Pisa, Italy
Respiration 73:603-9. 2006..The efficacy of nebulized corticosteroids in the prevention of exacerbation of chronic obstructive pulmonary disease (COPD) has been poorly studied... - Short-term effect of the addition of leukotriene receptor antagonists to the current therapy in severe asthmaticsM Tonelli
Cardiothoracic Department, Respiratory Pathophysiology, University of Pisa, Ospedale di Cisanello, Via Paradisa 2, Pisa 56100, Italy
Pulm Pharmacol Ther 16:237-40. 2003..The detection of these 'responders' could be relevant in the treatment of severe asthma... - A 4-year trial of tiotropium in chronic obstructive pulmonary diseaseDonald P Tashkin
David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
N Engl J Med 359:1543-54. 2008..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy... - Asthma control in patients with asthma and allergic rhinitis receiving add-on montelukast therapy for 12 months: a retrospective observational studyLuis Borderias
Pneumology Department, San Jorge Hospital, Huesca, Spain
Curr Med Res Opin 23:721-30. 2007..No studies to date have examined whether montelukast can improve asthma control over a long period of time in patients with seasonal AR and asthma...