Carlo Tascini

Summary

Country: Italy

Publications

  1. ncbi request reprint Linezolid treatment for gram-positive infections: a retrospective comparison with teicoplanin
    C Tascini
    Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    J Chemother 21:311-6. 2009
  2. ncbi request reprint Clinical efficacy of intravenous colistin therapy in combination with ceftazidime in severe MDR P. aeruginosa systemic infections in two haematological patients
    C Tascini
    Infectious Diseases Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy
    Infez Med 14:41-4. 2006
  3. ncbi request reprint Activity of ulifloxacin against clinical hospital isolates
    Giulia Geminiani
    Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Infez Med 15:169-73. 2007
  4. ncbi request reprint Three-times weekly teicoplanin as outpatient treatment of chronic osteoarticular infections
    C Tascini
    Infectious Diseases Unit, Cisanello Hospital, Pisa, Italy
    J Chemother 21:421-5. 2009
  5. ncbi request reprint [In vitro synergism of ulifloxacin plus piperacillin/tazobactam against clinical isolates of Enterobacteriaceae producing extended-spectrum or AmpC-type β-lactamases]
    Carlo Tascini
    U O Malattie Infettive, Ospedale Cisanello, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Infez Med 18:243-7. 2010
  6. pmc Daptomycin concentrations in valve tissue and vegetation in patients with bacterial endocarditis
    Carlo Tascini
    U O C Malattie Infettive, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Antimicrob Agents Chemother 57:601-2. 2013
  7. ncbi request reprint Microbiological activity and clinical efficacy of a colistin and rifampin combination in multidrug-resistant Pseudomonas aeruginosa infections
    C Tascini
    Infectious Diseases Unit, Azienda Ospedaliera Pisana, Pisa, Italy
    J Chemother 16:282-7. 2004
  8. ncbi request reprint Colistin in combination with rifampin and imipenem for treating a blaVIM-1 metallo-beta-lactamase-producing Enterobacter cloacae disseminated infection in a liver transplant patient
    C Tascini
    Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Minerva Anestesiol 74:47-9. 2008
  9. ncbi request reprint Acute varicella-zoster virus necrotizing meningoencephalomyelitis with sudden visual loss and paraparesis in an HIV-infected patient
    Carlo Tascini
    UO Malattie Infettive, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    New Microbiol 33:267-9. 2010
  10. ncbi request reprint Clinical and microbiological efficacy of colistin therapy alone or in combination as treatment for multidrug resistant Pseudomonas aeruginosa diabetic foot infections with or without osteomyelitis
    C Tascini
    Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    J Chemother 18:648-51. 2006

Detail Information

Publications36

  1. ncbi request reprint Linezolid treatment for gram-positive infections: a retrospective comparison with teicoplanin
    C Tascini
    Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    J Chemother 21:311-6. 2009
    ..05). Mortality due to infection was 9.8% in both groups, and adverse events were most frequently documented in linezolid-treated patients. Linezolid was clinically superior to teicoplanin in the treatment of Gram-positive infections...
  2. ncbi request reprint Clinical efficacy of intravenous colistin therapy in combination with ceftazidime in severe MDR P. aeruginosa systemic infections in two haematological patients
    C Tascini
    Infectious Diseases Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy
    Infez Med 14:41-4. 2006
    ..Therapeutical options are few. We describe two haematological patients with severe neutropenia and systemic infection due to MDR P. aeruginosa treated successfully with colistin plus ceftazidime. Severe adverse events were not described...
  3. ncbi request reprint Activity of ulifloxacin against clinical hospital isolates
    Giulia Geminiani
    Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Infez Med 15:169-73. 2007
    ..strains were included in the study. Ulifloxacin was slightly more active than ciprofloxacin and levofloxacin against gram negative isolates. Against gram positive strains ulifloxacin was as active as moxifloxacin...
  4. ncbi request reprint Three-times weekly teicoplanin as outpatient treatment of chronic osteoarticular infections
    C Tascini
    Infectious Diseases Unit, Cisanello Hospital, Pisa, Italy
    J Chemother 21:421-5. 2009
    ..9+/-13.6 mg/l and 52.2+/-27 mg/l. Adverse events occurred in 6 patients: mainly mild liver toxicity. Three times weekly teicoplanin seems to be a valuable option in the treatment of chronic infections...
  5. ncbi request reprint [In vitro synergism of ulifloxacin plus piperacillin/tazobactam against clinical isolates of Enterobacteriaceae producing extended-spectrum or AmpC-type β-lactamases]
    Carlo Tascini
    U O Malattie Infettive, Ospedale Cisanello, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Infez Med 18:243-7. 2010
    ..Clinical studies are needed to confirm in vivo the effectiveness of this regimen...
  6. pmc Daptomycin concentrations in valve tissue and vegetation in patients with bacterial endocarditis
    Carlo Tascini
    U O C Malattie Infettive, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Antimicrob Agents Chemother 57:601-2. 2013
    ..1 μg/g in perivalvular tissues. Daptomycin achieved apparently adequate tissue concentrations. S. epidermidis was eradicated, whereas Streptococcus oralis persisted, and its daptomycin MIC displayed a 4-fold increase...
  7. ncbi request reprint Microbiological activity and clinical efficacy of a colistin and rifampin combination in multidrug-resistant Pseudomonas aeruginosa infections
    C Tascini
    Infectious Diseases Unit, Azienda Ospedaliera Pisana, Pisa, Italy
    J Chemother 16:282-7. 2004
    ..aeruginosa which are difficult to cure...
  8. ncbi request reprint Colistin in combination with rifampin and imipenem for treating a blaVIM-1 metallo-beta-lactamase-producing Enterobacter cloacae disseminated infection in a liver transplant patient
    C Tascini
    Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Minerva Anestesiol 74:47-9. 2008
    ..The synergistic activity of this combination was demonstrated showing an increased activity of the serum bactericidal activity in comparison with the bactericidal activity of the serum taken during the previous therapy...
  9. ncbi request reprint Acute varicella-zoster virus necrotizing meningoencephalomyelitis with sudden visual loss and paraparesis in an HIV-infected patient
    Carlo Tascini
    UO Malattie Infettive, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    New Microbiol 33:267-9. 2010
    ..In conclusion, a diagnosis of CNS infection caused by VZV, based upon CSF analysis and examination of the skin for typical blisters, requires aggressive empiric antiviral therapy in order to maximise patient survival...
  10. ncbi request reprint Clinical and microbiological efficacy of colistin therapy alone or in combination as treatment for multidrug resistant Pseudomonas aeruginosa diabetic foot infections with or without osteomyelitis
    C Tascini
    Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    J Chemother 18:648-51. 2006
    ..aeruginosa...
  11. ncbi request reprint Clinical and microbiological efficacy of colistin therapy in combination with rifampin and imipenem in multidrug-resistant Pseudomonas aeruginosa diabetic foot infection with osteomyelitis
    Carlo Tascini
    Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Int J Low Extrem Wounds 5:213-6. 2006
    ..These data suggest that colistin, in combination with rifampin and imipenem, is safe and effective, in promoting healing in DFI due to MDR P aeruginosa and suggest the need for controlled clinical studies...
  12. ncbi request reprint Management of cardiac device infections: A retrospective survey of a non-surgical approach combining antibiotic therapy with transvenous removal
    C Tascini
    Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    J Chemother 18:157-63. 2006
    ..This procedure prevents recurrent infections and operative mortality...
  13. ncbi request reprint Efficacy of the combination ampicillin plus ceftriaxone in the treatment of a case of enterococcal endocarditis due to Enterococcus faecalis highly resistant to gentamicin: efficacy of the "ex vivo" synergism method
    C Tascini
    Division of Infectious Diseases, Pisa Hospital, Pisa, Italy
    J Chemother 16:400-3. 2004
    ..In this patient the two-drug combination was able to stop the bacteremia and prevent the infection of the prosthetic valve...
  14. pmc Synergistic activity of colistin plus rifampin against colistin-resistant KPC-producing Klebsiella pneumoniae
    Carlo Tascini
    UO Malattie Infettive, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Antimicrob Agents Chemother 57:3990-3. 2013
    ..Colistin-rifampin combinations may have a role in the treatment of multidrug-resistant K. pneumoniae and may possibly slow the selection of heteroresistant subpopulations during colistin therapy. ..
  15. doi request reprint Microbiology at first visit of moderate-to-severe diabetic foot infection with antimicrobial activity and a survey of quinolone monotherapy
    Carlo Tascini
    U O Malattie Infettive, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Diabetes Res Clin Pract 94:133-9. 2011
    ..Levofloxacin had the best clinical activity with respect to the other quinolones, but when it failed, selected more resistant strains with respect to moxifloxacin among S. aureus and with respect to ciprofloxacin among P. aeruginosa...
  16. ncbi request reprint Radiolabeled WBC scintigraphy in the diagnostic workup of patients with suspected device-related infections
    Paola A Erba
    Department of Translational Research and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy Electronic address
    JACC Cardiovasc Imaging 6:1075-86. 2013
    ....
  17. doi request reprint Micafungin for Candida albicans pacemaker-associated endocarditis: a case report and review of the literature
    Carlo Tascini
    U O Malattie Infettive, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Mycopathologia 175:129-34. 2013
    ..Noteworthy, a high micafungin concentration was documented into the lead vegetation (10 μg/g of vegetation tissue) and this may have contributed to the striking size reduction of vegetation...
  18. doi request reprint Comparison of teicoplanin and vancomycin in vitro activity on clinical isolates of Staphylococcus aureus
    Carlo Tascini
    U O C Malattie Infettive, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    J Chemother 24:187-90. 2012
    ..A teicoplanin MIC creep, as reported for vancomycin, cannot be assumed...
  19. doi request reprint Cardiovascular implantable electronic device endocarditis treated with daptomycin with or without transvenous removal
    Carlo Tascini
    Unita Operativa Malattie Infettive, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Heart Lung 41:e24-30. 2012
    ..The CIED was removed transvenously in 7 patients. Two patients were too sick for the removal of their CIED, and were cured with 6 mg/kg of daptomycin for 60 and 110 days, respectively, without adverse events...
  20. doi request reprint A single-staggered dose of calcineurin inhibitor may be associated with neurotoxicity and nephrotoxicity immediately after liver transplantation
    Lucio Urbani
    General Surgery and Liver Transplantation Unit, Azienda Ospedaliero Universitaria Pisana, Ospedale Cisanello, Pisa, Italy
    Clin Transplant 23:853-60. 2009
    ....
  21. doi request reprint Carbapenem-sparing antibiotic regimens for infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae in intensive care unit
    Francesco Sbrana
    Fondazione Toscana Gabriele Monasterio, Azienda Ospedaliera Universitaria Pisana, Italy
    Clin Infect Dis 56:697-700. 2013
    ..The 30-day crude mortality rate was 14%. Regimens were considered appropriate in 12% of episodes according to the Vitek 2 System and in 100% based on E-test...
  22. doi request reprint A novel immunosuppressive strategy combined with preemptive antiviral therapy improves the eighteen-month mortality in HCV recipients transplanted with aged livers
    Lucio Urbani
    Department of Liver Transplantation, General Surgery and Liver Transplantation Unit, Azienda Ospedaliero Universitaria Pisana, Cisanello Hospital, Pisa, Italy
    Transplantation 86:1666-71. 2008
    ..We analyzed the 18-month mortality in 302 consecutive HCV recipients, divided into three groups, with homogeneous immunosuppression and preemptive antiviral therapy in the last group...
  23. doi request reprint 111In-DTPA-Biotin uptake by Staphylococcus aureus
    Paola Anna Erba
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Pisa, Italy
    Nucl Med Commun 31:994-7. 2010
    ..Our data seem to demonstrate a passive transport of In-DTPA-Biotin into the cells of the microorganisms...
  24. ncbi request reprint Oral gentamicin gut decontamination for prevention of KPC-producing Klebsiella pneumoniae infections: relevance of concomitant systemic antibiotic therapy
    Carlo Tascini
    Infectious Diseases Unit, Cisanello Hospital, Pisa, Italy
    Antimicrob Agents Chemother 58:1972-6. 2014
    ..Oral gentamicin was shown to be potentially useful for gut decontamination and prevention of infection due to KPC-Kp, especially in patients not receiving CSAT. The risk of emergence of gentamicin-resistant KPC-Kp should be considered...
  25. pmc Case report of a successful treatment of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and MRSA/vancomycin-resistant Enterococcus faecium cholecystitis by daptomycin
    Carlo Tascini
    Infectious Diseases Unit, Santa Chiara University Hospital, and Division of Pharmacology, Department of Internal Medicine, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Antimicrob Agents Chemother 55:2458-9. 2011
    ..Therefore, daptomycin achieved therapeutic levels in bile, hence suggesting a role for the drug in the treatment of MRSA/VRE cholecystitis...
  26. doi request reprint A rapid high-performance liquid chromatography method to measure linezolid and daptomycin concentrations in human plasma
    Marialuisa Polillo
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Ther Drug Monit 32:200-5. 2010
    ....
  27. doi request reprint Scintigraphic imaging of vertebral osteomyelitis with 111in-biotin
    Elena Lazzeri
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Italy
    Spine (Phila Pa 1976) 33:E198-204. 2008
    ..All patients suspected to have vertebral infection underwent radiologic imaging and In-Biotin scintigraphy...
  28. ncbi request reprint Colistin, meropenem and rifampin in a combination therapy for multi-drug-resistant Acinetobacter baumannii multifocal infection. A case report
    G Biancofiore
    Unit of Infectious Diseases, Postsurgical and Transplant Intensive Care Unit Azienda Ospedaliero Universitaria Pisana Cisanello Hospital, Pisa, Italy
    Minerva Anestesiol 73:181-5. 2007
    ....
  29. doi request reprint Clinical pharmacokinetics of antibacterials in cerebrospinal fluid
    Antonello Di Paolo
    Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 55, 56126, Pisa, Italy
    Clin Pharmacokinet 52:511-42. 2013
    ....
  30. doi request reprint Added value of 99mTc-HMPAO-labeled leukocyte SPECT/CT in the characterization and management of patients with infectious endocarditis
    Paola A Erba
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    J Nucl Med 53:1235-43. 2012
    ....
  31. doi request reprint Prulifloxacin: clinical studies of a broad-spectrum quinolone agent
    Gianluca Giannarini
    Department of Urology, University of Pisa, Pisa, Italy
    Future Microbiol 4:13-24. 2009
    ..Additional research is needed to further elucidate the promising role of prulifloxacin in the treatment of infections sustained by multidrug-resistant pathogens and to consolidate the wide spectrum of activity from a clinical standpoint...
  32. doi request reprint The role of immunomodulation in ABO-incompatible adult liver transplant recipients
    Lucio Urbani
    Liver Transplant Unit, Azienda Ospedaliero Universitaria Pisana, Ospedale Cisanello, Pisa, Italy
    J Clin Apher 23:55-62. 2008
    ....
  33. doi request reprint Clinical impact of SPECT/CT with In-111 biotin on the management of patients with suspected spine infection
    Elena Lazzeri
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    Clin Nucl Med 35:12-7. 2010
    ..Early identification and localization of spine infection is necessary for adequate therapeutic strategy. To localize the precise site of infection we evaluated In-111 Biotin SPECT/CT versus planar and SPECT imaging...
  34. doi request reprint A randomized controlled trial to examine the efficacy and safety of a new super-oxidized solution for the management of wide postsurgical lesions of the diabetic foot
    A Piaggesi
    Department of Endocrinology and Metabolism Azienda Ospedaliero Universitaria Pisana, Pisa, Italy
    Int J Low Extrem Wounds 9:10-5. 2010
    ..01). DWC is as safe as and more effective than standard local antiseptics in the management of wide postsurgical lesions in the infected diabetic foot...
  35. ncbi request reprint Liver transplantation due to Herpes Simplex virus-related sepsis causing massive hepatic necrosis after thoracoscopic thymectomy
    G Biancofiore
    Post surgical and Transplant Intensive Care Unit, Cisanello Hospital, Pisa, Italy
    Minerva Anestesiol 73:319-22. 2007
    ..If a liver transplantation becomes mandatory, careful consideration should be given to the extent of the viral infection and its response to therapy because of the possibility of viral spread to the graft...
  36. ncbi request reprint Potential applications of extracorporeal photopheresis in liver transplantation
    L Urbani
    Liver Transplant Unit, Azienda Ospedaliero Universitaria Pisana, Ospedale Cisanello, Pisa, Italy
    Transplant Proc 40:1175-8. 2008
    ..0% and a sustained virological response of 38.9%. These preliminary results await validation in larger prospective studies with longer follow-up periods...