Giorgio Bernardi

Summary

Affiliation: Stazione Zoologica Anton Dohrn
Country: Italy

Publications

  1. pmc The neoselectionist theory of genome evolution
    Giorgio Bernardi
    Molecular Evolution Laboratory, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Proc Natl Acad Sci U S A 104:8385-90. 2007
  2. ncbi request reprint Lessons from a small, dispensable genome: the mitochondrial genome of yeast
    Giorgio Bernardi
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Gene 354:189-200. 2005
  3. ncbi request reprint Isochore patterns and gene distributions in fish genomes
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Genomics 90:364-71. 2007
  4. ncbi request reprint Incorrectly predicted genes in rice?
    Stephane Cruveiller
    Laboratorio di Evoluzione Molecolare, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Gene 333:187-8. 2004
  5. doi request reprint Distribution of DNA methylation, CpGs, and CpG islands in human isochores
    Annalisa Varriale
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Genomics 95:25-8. 2010
  6. pmc Compositional genome contexts affect gene expression control in sea urchin embryo
    Abdullah Al Mahmud
    Stazione Zoologica Anton Dohrn Napoli, Villa Comunale, Napoli, Italy
    PLoS ONE 3:e4025. 2008
  7. ncbi request reprint DNA methylation and body temperature in fishes
    Annalisa Varriale
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Napoli, Italy
    Gene 385:111-21. 2006
  8. pmc Mapping insertions, deletions and SNPs on Venter's chromosomes
    Maria Costantini
    Stazione Zoologica Anton Dohrn, Naples, Italy
    PLoS ONE 4:e5972. 2009
  9. doi request reprint Environmental genomics: a tale of two fishes
    Giuseppe Bucciarelli
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, Napoli, Italy
    Mol Biol Evol 26:1235-43. 2009
  10. ncbi request reprint Human chromosomal bands: nested structure, high-definition map and molecular basis
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Naples, Italy
    Chromosoma 116:29-40. 2007

Collaborators

Detail Information

Publications62

  1. pmc The neoselectionist theory of genome evolution
    Giorgio Bernardi
    Molecular Evolution Laboratory, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Proc Natl Acad Sci U S A 104:8385-90. 2007
    ..In conclusion, the neoselectionist theory not only provides a solution to the neutralist/selectionist debate but also introduces an epigenomic component in genome evolution...
  2. ncbi request reprint Lessons from a small, dispensable genome: the mitochondrial genome of yeast
    Giorgio Bernardi
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Gene 354:189-200. 2005
    ..This work led to some general conclusions on the nuclear genome of eukaryotes. Some recent results in apparent contradiction with our conclusions on ori sequences will also be briefly discussed...
  3. ncbi request reprint Isochore patterns and gene distributions in fish genomes
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Genomics 90:364-71. 2007
    ..Moreover, in each genome the GC-poorest isochore families comprised a group of "long isochores" (2-20 Mb in size), which were the lowest in GC and varied in size distribution and relative amount from one genome to the other...
  4. ncbi request reprint Incorrectly predicted genes in rice?
    Stephane Cruveiller
    Laboratorio di Evoluzione Molecolare, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Gene 333:187-8. 2004
    ..e., sequences that are never translated into functional proteins in vivo...
  5. doi request reprint Distribution of DNA methylation, CpGs, and CpG islands in human isochores
    Annalisa Varriale
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Genomics 95:25-8. 2010
    ..This conclusion supports the idea that the widespread methylation under consideration here has a general inhibitory effect on gene expression...
  6. pmc Compositional genome contexts affect gene expression control in sea urchin embryo
    Abdullah Al Mahmud
    Stazione Zoologica Anton Dohrn Napoli, Villa Comunale, Napoli, Italy
    PLoS ONE 3:e4025. 2008
    ..Therefore although the way a gene works depends on the information contained in its cis-regulatory region, availability of such information depends on the compositional properties of the genomic context...
  7. ncbi request reprint DNA methylation and body temperature in fishes
    Annalisa Varriale
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Napoli, Italy
    Gene 385:111-21. 2006
    ..These results confirm the existence of an inverse relationship between DNA methylation and body temperature, when the latter is maintained over evolutionary times...
  8. pmc Mapping insertions, deletions and SNPs on Venter's chromosomes
    Maria Costantini
    Stazione Zoologica Anton Dohrn, Naples, Italy
    PLoS ONE 4:e5972. 2009
    ..The very recent availability of fully sequenced individual human genomes is a major revolution in biology which is certainly going to provide new insights into genetic diseases and genomic rearrangements...
  9. doi request reprint Environmental genomics: a tale of two fishes
    Giuseppe Bucciarelli
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, Napoli, Italy
    Mol Biol Evol 26:1235-43. 2009
    ....
  10. ncbi request reprint Human chromosomal bands: nested structure, high-definition map and molecular basis
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Naples, Italy
    Chromosoma 116:29-40. 2007
    ....
  11. pmc The evolution of isochore patterns in vertebrate genomes
    Maria Costantini
    Stazione Zoologica Anton Dohrn, Naples, Italy
    BMC Genomics 10:146. 2009
    ..g., between amphibians and mammals); and (v) isochores are tightly linked to a number of basic biological properties, such as gene density, gene expression, replication timing and recombination...
  12. doi request reprint GC level and expression of human coding sequences
    Stilianos Arhondakis
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Biochem Biophys Res Commun 367:542-5. 2008
    ..Here we show that, while the protocols used eliminated the original genomic context, they replaced it with the plasmid contexts whose compositional properties affected the results...
  13. doi request reprint Mapping DNase-I hypersensitive sites on human isochores
    Miriam Di Filippo
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Gene 419:62-5. 2008
    ....
  14. ncbi request reprint LDH-A and alpha-actin as tools to assess the effects of temperature on the vertebrate genome: some problems
    Oliver Clay
    Laboratorio di Evoluzione Molecolare, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121, Naples, Italy
    Gene 317:157-60. 2003
    ..We argue here that the data presented neither prove nor suggest such a conclusion because of conceptual and methodological errors...
  15. ncbi request reprint Using analytical ultracentrifugation to study compositional variation in vertebrate genomes
    Oliver Clay
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, Italy
    Eur Biophys J 32:418-26. 2003
    ..Such comparisons also allow consistency checks of phylogenetic hypotheses at different taxonomic levels. We here discuss some of the information that can be deduced from CsCl profiles, with emphasis on mammalian DNAs...
  16. doi request reprint Correlations between coding and contiguous non-coding sequences in isochore families from vertebrate genomes
    Maria Costantini
    Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Gene 410:241-8. 2008
    ....
  17. ncbi request reprint Isochore pattern and gene distribution in the chicken genome
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Gene 400:9-15. 2007
    ..This raises important questions about genome evolution in vertebrates...
  18. ncbi request reprint Compositional patterns in reptilian genomes
    Sandrine Hughes
    Laboratorio di Evoluzione Molecolare, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121, Naples, Italy
    Gene 295:323-9. 2002
    ....
  19. doi request reprint Extrapolating ENCODE data to the whole human genome
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Gene 419:66-9. 2008
    ..This unbalanced representativity of ENCODE can, however, be corrected by multiplying ENCODE data by a G/E factor (the ratio of whole genome data over ENCODE data), so amplifying the potential interest of ENCODE...
  20. doi request reprint The distributions of "new" and "old" Alu sequences in the human genome: the solution of a "mystery"
    Maria Costantini
    Laboratory of Cellular and Developmental Biology, Stazione Zoologica Anton Dohrn, Naples, Italy
    Mol Biol Evol 29:421-7. 2012
    ....
  21. pmc The isochore patterns of invertebrate genomes
    Rosalia Cammarano
    Stazione Zoologica Anton Dohrn, Naples, Italy
    BMC Genomics 10:538. 2009
    ..A question raised by these results concerned how far back in evolution an isochore organization of the eukaryotic genome arose...
  22. pmc Compositional properties and thermal adaptation of 18S rRNA in vertebrates
    Annalisa Varriale
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    RNA 14:1492-500. 2008
    ..In these cases, differences similar to those already mentioned were found. We conclude that there is a correlation between stem stability and body temperature even within the relatively limited temperature range of vertebrates...
  23. ncbi request reprint Compositional properties of human cDNA libraries: practical implications
    Stilianos Arhondakis
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    FEBS Lett 580:5772-8. 2006
    ..We propose the use of compositional distributions of raw ESTs from a cDNA library, and/or of the genes they represent, as a simple and effective tool for quality control...
  24. pmc Replication timing, chromosomal bands, and isochores
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Proc Natl Acad Sci U S A 105:3433-7. 2008
    ..Finally, we show that our results should be representative for the whole human genome and thus help to predict replication timing zones in all chromosomes...
  25. pmc Compositional gene landscapes in vertebrates
    Stephane Cruveiller
    Laboratorio di Evoluzione Molecolare, Stazione Zoologica Anton Dohrn, 80121 Napoli, Italy
    Genome Res 14:886-92. 2004
    ..The landscapes therefore portray relations between proteins and the DNA environments of the genes that encode them...
  26. ncbi request reprint The new genes of rice: a closer look
    Kamel Jabbari
    Laboratoire di Evoluzione Molecolare, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Trends Plant Sci 9:281-5. 2004
  27. ncbi request reprint DNA methylation in reptiles
    Annalisa Varriale
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Napoli, Italy
    Gene 385:122-7. 2006
    ..We discuss some ecological and physiological data that explain these results...
  28. doi request reprint Compositional patterns in the genomes of unicellular eukaryotes
    Maria Costantini
    Laboratory of Animal Physiology and Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, Naples 80121, Italy
    BMC Genomics 14:755. 2013
    ..A question raised by these basic results concerns how far back in evolution the compartmentalized organization of the eukaryotic genomes arose...
  29. pmc The short-sequence designs of isochores from the human genome
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Proc Natl Acad Sci U S A 105:13971-6. 2008
    ....
  30. ncbi request reprint Organization and base composition of tilapia Hox genes: implications for the evolution of Hox clusters in fish
    Simona Santini
    Molecular Evolution Laboratory, Stazione Zoologica A Dohrn, Villa Comunale, 80121 Napoli, Italy
    Gene 346:51-61. 2005
    ..The relationship between the decrease of GC level and the loss of conservation and function of one of the paralogous genes from twin clusters is discussed...
  31. pmc The early apoptotic DNA fragmentation targets a small number of specific open chromatin regions
    Miriam Di Filippo
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Naples, Italy
    PLoS ONE 4:e5010. 2009
    ..In conclusion, the approach presented here, which is the mildest and least intrusive approach, identifies a preferred accessibility landscape in interphase chromatin...
  32. ncbi request reprint The influence of translational selection on codon usage in fishes from the family Cyprinidae
    Hector Romero
    Laboratorio di Evoluzione Molecolare, Stazione Zoologica Anton Dohrn, Villa Comunale, Naples 80121, Italy
    Gene 317:141-7. 2003
    ..Finally, we raise the possibility that the same phenomena will be found among warm-blooded vertebrates...
  33. ncbi request reprint An analysis of the genome of Ciona intestinalis
    Giuliana de Luca di Roseto
    Laboratorio di Evoluzione Molecolare, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121, Naples, Italy
    Gene 295:311-6. 2002
    ....
  34. pmc An isochore map of human chromosomes
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Genome Res 16:536-41. 2006
    ....
  35. ncbi request reprint An ultracentrifugation analysis of two hundred fish genomes
    Giuseppe Bucciarelli
    Laboratorio di Evoluzione Molecolare, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121, Naples, Italy
    Gene 295:153-62. 2002
    ..Mol. Evol. 31 (1990) 265]. This suggests that, in all likelihood, the properties reported in the present paper can be considered as generally valid for all fish genomes...
  36. ncbi request reprint The major shifts of human duplicated genes
    Kamel Jabbari
    Laboratoire de Genetique Moleculaire, Institut Jacques Monod, 2 place Jussieu, F 75005 Paris, France
    Gene 317:203-8. 2003
    ....
  37. ncbi request reprint GC3 heterogeneity and body temperature in vertebrates
    Kamel Jabbari
    Laboratoire de Genetique Moleculaire, Institut Jacques Monod, 2 place Jussieu, F 75005 Paris, France
    Gene 317:161-3. 2003
    ..We have analyzed the data of Belle et al. and find that their data not only do not contradict the thermal stability hypothesis, but if anything support it...
  38. ncbi request reprint The pig genome: compositional analysis and identification of the gene-richest regions in chromosomes and nuclei
    Concetta Federico
    Dipartimento di Biologia Animale M La Greca, University of Catania, Via Androne 81, 95124 Catania, Italy
    Gene 343:245-51. 2004
    ..At the cell nucleus level, we observed that the gene-dense region corresponded to the more internal compartment, as previously found in human and avian cell nuclei...
  39. ncbi request reprint The correlation between GC3 and hydropathy in human genes
    Kamel Jabbari
    Laboratoire de Genetique Moleculaire, Institut Jacques Monod, 2 place Jussieu, 75005 Paris, France
    Gene 317:137-40. 2003
    ..More generally, for any explanation via two chained correlations, the intermediate property would need to be strongly correlated with hydrophobicity and/or GC(3)...
  40. ncbi request reprint Localization of the gene-richest and the gene-poorest isochores in the interphase nuclei of mammals and birds
    Salvatore Saccone
    Dipartimento di Biologia Animale, University of Catania, Via Androne 81, 95124, Catania, Italy
    Gene 300:169-78. 2002
    ..This finding has interesting implications for the formation of GC-rich isochores of warm-blooded vertebrates...
  41. ncbi request reprint Isochores, GC3 and mutation biases in the human genome
    Fernando Alvarez-Valin
    Seccion Biomatematica, Facultad de Ciencias, Montevideo, Uruguay
    Gene 300:161-8. 2002
    ..Instead, GC(3)-rich and very GC(3)-rich genes exhibit patterns of mutations that yield expectations of neutral GC(3) content that are much lower than their actual GC(3)...
  42. ncbi request reprint Representing GC variation along eukaryotic chromosomes
    Jan Paces
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo 2, Prague CZ 16637, Czech Republic
    Gene 333:135-41. 2004
    ..Supplementary information, including a database of color-coded GC profiles for all recently sequenced eukaryotes and the program draw_chromosomes_gc.pl used to obtain them, are available at...
  43. ncbi request reprint Body temperature and evolutionary genomics of vertebrates: a lesson from the genomes of Takifugu rubripes and Tetraodon nigroviridis
    Kamel Jabbari
    Laboratoire de Genetique Moleculaire, Institut Jacques Monod, 2 place Jussieu, F 75005 Paris, France
    Gene 333:179-81. 2004
    ..Such an effect does not only concern large DNA segments but also coding sequences...
  44. ncbi request reprint How not to search for isochores: a reply to Cohen et Al
    Oliver Clay
    Mol Biol Evol 22:2315-7. 2005
    ..Thus, they over-fragment GC-rich isochores (and also many GC-poor isochores) beyond recognition...
  45. ncbi request reprint Cytosine methylation and CpG, TpG (CpA) and TpA frequencies
    Kamel Jabbari
    Laboratoire de Genetique Moleculaire, Institut Jacques Monod, 2 place Jussieu, F 75005 Paris, France
    Gene 333:143-9. 2004
    ..The implications of these results are discussed...
  46. ncbi request reprint Avian genomes: different karyotypes but a similar distribution of the GC-richest chromosome regions at interphase
    Concetta Federico
    Dipartimento di Biologia Animale M La Greca, University of Catania, Italy
    Chromosome Res 13:785-93. 2005
    ..Indeed, in spite of the different size and morphology of the chromosomes, the gene-dense regions are always located in the interior of the nuclei...
  47. ncbi request reprint The evolution of introns in human duplicated genes
    Edda Rayko
    Laboratoire de Genetique Moleculaire, Institut Jacques Monod, 2 place Jussieu, F 75005 Paris, France
    Gene 365:41-7. 2006
    ..The features of the copies that underwent the compositional transition and became GC-richer are suggestive of, or related to, functional changes...
  48. ncbi request reprint Gene-rich and gene-poor chromosomal regions have different locations in the interphase nuclei of cold-blooded vertebrates
    Concetta Federico
    Dipartimento di Biologia Animale M La Greca, University of Catania, Via Androne 81, 95124, Catania, Italy
    Chromosoma 115:123-8. 2006
    ....
  49. ncbi request reprint A compact view of isochores in the draft human genome sequence
    Adam Pavlicek
    Laboratoire de Genetique Moleculaire, Institut Jacques Monod, 75005 Paris, France
    FEBS Lett 511:165-9. 2002
    ..The draft sequence now permits the visualization of the mosaic organization of the human genome at the DNA sequence level...
  50. ncbi request reprint Isochores: dream or reality?
    Oliver Clay
    Trends Biotechnol 20:237. 2002
  51. ncbi request reprint Comparative genomics of Anopheles gambiae and Drosophila melanogaster
    Kamel Jabbari
    Laboratoire de Genetique Moleculaire, Institut Jacques Monod, 2 place Jussieu, F 75005 Paris, France
    Gene 333:183-6. 2004
    ..These findings, which describe a compositional shift within Diptera, is of interest because of their parallels in the well studied major shift in vertebrates...
  52. ncbi request reprint Isochore conservation between MHC regions on human chromosome 6 and mouse chromosome 17
    Adam Pavlicek
    FEBS Lett 511:175-7. 2002
  53. ncbi request reprint Association analysis between Alzheimer's disease and the Nicastrin gene polymorphisms
    Antonio Orlacchio
    Laboratorio di Neurogenetica, IRCCS Santa Lucia, Via Ardeatina 354, 00179, Rome, Italy
    Neurosci Lett 333:115-8. 2002
    ..But considering its biological effects, the result can not exclude the NCSTN as candidate for genetic factor in AD. Further genetic study of the NCSTN would be necessary to evaluate the potential genetic involvement in AD...
  54. ncbi request reprint The base composition of the genes is correlated with the secondary structures of the encoded proteins
    Giuseppe d'Onofrio
    Laboratorio di Evoluzione Molecolare, Stazione Zoologica A Dohrn, Naples, Italy
    Gene 300:179-87. 2002
    ..These results are not compatible with any proposed hypotheses based on a neutral process of formation/maintenance of the high GC(3) levels of the genes localized in the GC-richest isochores of the human genome...
  55. ncbi request reprint Inaccurate reconstruction of ancestral GC levels creates a "vanishing isochores" effect
    Fernando Alvarez-Valin
    Seccion Biomatematica, Facultad de Ciencias, Montevideo 11400, Uruguay
    Mol Phylogenet Evol 31:788-93. 2004
    ..They are therefore likely to explain many if not all of the observations, rendering unnecessary the general hypothesis of vanishing GC-rich isochores in mammals...
  56. ncbi request reprint Correlations between genomic GC levels and optimal growth temperatures in prokaryotes
    Hector Musto
    Laboratorio de Organización y Evolución del Genoma, Facultad de Ciencias, Montevideo, Uruguay
    FEBS Lett 573:73-7. 2004
    ..We conclude that Topt is one of the factors that influences genomic GC in prokaryotes...
  57. ncbi request reprint Simple proteomic checks for detecting noncoding RNA
    Stephane Cruveiller
    Atelier de Génomique Comparative, Genoscope, Centre National de Séquençage, Evry, France
    Proteomics 7:361-3. 2007
    ....
  58. ncbi request reprint Quantifying intrachromosomal GC heterogeneity in prokaryotic genomes
    Pedro Bernaola-Galvan
    Dpto de Física Aplicada II, Universidad de Malaga, E 29071, Malaga, Spain
    Gene 333:121-33. 2004
    ..Supplementary results for all species analyzed are available at our website: http://bioinfo2.ugr.es/prok...
  59. ncbi request reprint New locus for hereditary spastic paraplegia maps to chromosome 1p31.1-1p21.1
    Antonio Orlacchio
    Laboratorio di Neurogenetica, Centro Europeo di Ricerca sul Cervello Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia, Rome, Italy
    Ann Neurol 58:423-9. 2005
    ..3cM between markers D1S2889 and D1S248. Sequencing of one candidate gene in the region (sorting nexin 7, SNX7), involved in several stages of intracellular trafficking and protein transport, showed no disease-causing mutations...
  60. ncbi request reprint Genomic GC level, optimal growth temperature, and genome size in prokaryotes
    Hector Musto
    Laboratorio de Organización y Evolución del Genoma, Facultad de Ciencias, Montevideo, Uruguay
    Biochem Biophys Res Commun 347:1-3. 2006
    ..Furthermore, we demonstrate that the relationship that exists between genome size and GC level is valid for aerobic, facultative, and microaerophilic species, but not for anaerobic prokaryotes...
  61. ncbi request reprint Novel SPG6 mutation p.A100T in a Japanese family with autosomal dominant form of hereditary spastic paraplegia
    Satoshi Kaneko
    Department of Neurology, Kitano Hospital, The Tazuke Kofukai Medical Institute, Osaka, Japan
    Mov Disord 21:1531-3. 2006
    ..A100T in SPG6 resulted in an autosomal dominant form of hereditary spastic paraplegia (ADHSP). Clinical investigation showed a pure form of HSP. Our study demonstrates further allelic heterogeneity of SPG6...
  62. ncbi request reprint The correlation between genomic G+C and optimal growth temperature of prokaryotes is robust: a reply to Marashi and Ghalanbor
    Hector Musto
    Laboratorio de Organización y Evolución del Genoma, Facultad de Ciencias, Montevideo, Uruguay
    Biochem Biophys Res Commun 330:357-60. 2005
    ..The results presented here reinforce our previous proposal that T(opt) is correlated with genomic GC in prokaryotes...