Research Topics
Species | Alessandro SquizzatoSummaryCountry: Italy Publications
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Publications
Viral hepatitis and thrombosis: a narrative reviewAlessandro Squizzato
Department of Clinical Medicine, University of Insubria, Varese, Italy
Semin Thromb Hemost 38:530-4. 2012..The hemostatic state in chronic liver disease and the role of coagulation in liver fibrosis will also be discussed...- Prognostic clinical prediction rules to identify a low-risk pulmonary embolism: a systematic review and meta-analysisA Squizzato
Research Center on Thromboembolic Disorders and Antithrombotic Therapies, Department of Clinical Medicine, University of Insubria, Varese, Italy
J Thromb Haemost 10:1276-90. 2012..A number of clinical prediction rules (CPRs) have been proposed for stratifying PE mortality risk. The aim of this systematic review was to assess the performance of prognostic CPRs in identifying a low-risk PE... - Thromboprophylaxis in day surgeryAlessandro Squizzato
Department of Clinical Medicine, University of Insubria, Varese, Italy
Int J Surg 6:S29-30. 2008.... - Novel risk factors for venous thromboembolismAlessandro Squizzato
Department of Clinical Medicine, University of Insubria, UO Medicina I, Ospedale di Circolo, Varese, Italy
Hematol Oncol Clin North Am 24:709-16, viii. 2010..In this article, the authors focus on the most promising, persistent, and potentially treatable novel risk factors... - Treatment options for deep vein thrombosisAlessandro Squizzato
University of Insubria, Research Center on Thromboembolic Disorders and Antithrombotic Therapies, Department of Clinical Medicine, U O Medicina I Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
Expert Opin Pharmacother 11:1069-75. 2010..More recently, we have been experiencing a rapidly changing situation thanks to the development of new orally active anticoagulants... 
A case report and literature review of portal vein thrombosis associated with cytomegalovirus infection in immunocompetent patientsA Squizzato
Department of Clinical Medicine, University of Insubria, Varese, 21100, Italy
Clin Infect Dis 44:e13-6. 2007..Published data suggest that CMV hepatitis and, possibly, other types of acute viral hepatitis could be a local risk factor for acute PVT...- Antithrombotic and fibrinolytic drugs for retinal vein occlusion: a systematic review and a call for actionA Squizzato
Medicina I Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
Thromb Haemost 103:271-6. 2010..No firm recommendation can be provided given the limited available evidence... - Clinical review: Thyroid dysfunction and effects on coagulation and fibrinolysis: a systematic reviewA Squizzato
Department of Clinical Medicine, University of Insubria, Varese, Italy
J Clin Endocrinol Metab 92:2415-20. 2007..The purpose of this systematic review is to summarize the effects of hyperthyroidism and hypothyroidism on these systems... - Subclinical hypothyroidism and deep venous thrombosis. A pilot cross-sectional studyAlessandro Squizzato
Department of Clinical Medicine, University of Insubria, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
Thromb Haemost 97:803-6. 2007..The results of this pilot study suggest an increased prevalence of subclinical hypothyroidism in patients with unDVT. The clinical relevance of these preliminary findings needs to be addressed in larger prospective studies... - The coagulation system in endocrine disorders: a narrative reviewA Squizzato
Department of Clinical Medicine, University of Insubria, Varese, Italy
Intern Emerg Med 2:76-83. 2007..Also effects of pheochromocytoma, hyperprolactinaemia and hyperaldosteronism on the coagulation system have been described. It is apparent that unprovoked bleeding and thrombotic episodes can be secondary to endocrine disorders... - Recurrent deep venous thrombosis during optimal anticoagulation and overt hyperthyroidism: a case reportAlessandro Squizzato
Department of Clinical Medicine, University of Insubria, Varese, Italy
Blood Coagul Fibrinolysis 18:801-3. 2007.... - New direct thrombin inhibitorsAlessandro Squizzato
Department of Clinical Medicine, University of Insubria, Varese, Italy
Intern Emerg Med 4:479-84. 2009..However, only reports from clinical practice patterns over the next months and years will tell us how and when to use the new DTIs... - Diagnosis and management of venous thromboembolism: Results of a survey on current clinical practiceAlessandro Squizzato
Department of Clinical Medicine, University of Insubria, Varese, Italy
Thromb Res 125:134-6. 2010..We developed a standardized questionnaire to explore clinical practice patterns in the management of VTE, in particular about the use of pre-clinical probability and D-dimer testing and on the home treatment of pulmonary embolism (PE)... - Recombinant activated factor VII as a general haemostatic agent: evidence-based efficacy and safetyAlessandro Squizzato
Department of Clinical Medicine, University of Insubria, Varese, Italy
Curr Drug Saf 2:155-61. 2007..In the last few years it has been increasingly used 'off label' in medical and surgical patients to minimise or control severe or refractory bleeding, in particular when conventional therapy failed or was judged to be insufficient... - Outpatient treatment and early discharge of symptomatic pulmonary embolism: a systematic reviewA Squizzato
Department of Clinical Medicine, University of Insubria, Varese, Italy
Eur Respir J 33:1148-55. 2009.... - The new oral anticoagulants, do they change the benefit vs. risk for thromboprophylaxis in association to ambulatory surgery?Alessandro Squizzato
Research Center on Thromboembolic Disorders and on Antithrombotic Therapies, Department of Clinical Medicine, University of Insubria, Varese, Italy
Curr Opin Anaesthesiol 23:722-5. 2010..Two new drug classes, the direct thrombin and factor Xa (FXa) inhibitors, have been developed with a potentially better risk-benefit profile... - Statins, fibrates, and venous thromboembolism: a meta-analysisAlessandro Squizzato
Department of Clinical Medicine, University of Insubria, Varese, Italy
Eur Heart J 31:1248-56. 2010..The aim is to make a systematic review of the literature to assess the effect of lipid-lowering drugs on venous thromboembolism (VTE) occurrence... - The influence of pituitary, adrenal, and parathyroid hormones on hemostasis and thrombosisAlessandro Squizzato
Research Center on Thromboembolic Disorders and Antithrombotic Therapies, Department of Clinical Medicine, University of Insubria, Varese, Italy
Semin Thromb Hemost 37:41-8. 2011..However, the clinical relevance is still unproven. Until definitive evidence is available, clinicians should be aware of the possibility that endocrine disorders may be risk factors for thrombotic events... - Effects of human cytomegalovirus infection on the coagulation systemAlessandro Squizzato
Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
Thromb Haemost 93:403-10. 2005..Definitive conclusions, however, cannot be drawn, although the in vitro studies are convincing and offer insight in the pathogenesis... - Thyroid diseases and cerebrovascular diseaseA Squizzato
Department of Vascular Medicine, Academical Medical Center, Amsterdam, The Netherlands
Stroke 36:2302-10. 2005.... - Incidence of thromboembolic complications in patients with atrial fibrillation or mechanical heart valves with a subtherapeutic international normalized ratio: a prospective multicenter cohort studyFrancesco Dentali
Department of Clinical Medicine, Insubria University, Varese, Italy
Am J Hematol 87:384-7. 2012..Given the frequent observation of subtherapeutic INR levels when monitoring vitamin K antagonists, this finding warrants additional investigation to improve the management of these patients... 
Increasing levels of free thyroxine as a risk factor for a first venous thrombosis: a case-control studyBregje van Zaane
Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
Blood 115:4344-9. 2010..0 (95% CI, 1.1-154.1) for FT(4) levels above reference range. Our data suggest increasing levels of FT(4) to be a risk factor for VT and may have implications for both the prevention and management of this disease...- The initial phase of oral anticoagulation with warfarin in outpatients with deep venous thrombosisWalter Ageno
Department of Internal Medicine, University of Insubria, Varese, Italy
Blood Coagul Fibrinolysis 14:11-4. 2003..039). Patients younger than 60 years old had an odds ratio for an extended treatment of 4.92 (P = 0.0057). Algorithms with different loading doses of warfarin according to age should be proposed for outpatient treatment of DVT... - Prolactin and venous thrombosis: indications for a novel risk factor?Bregje van Zaane
Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
Arterioscler Thromb Vasc Biol 31:672-7. 2011..Several acquired risk factors for venous thrombosis (VT) are associated with high prolactin levels. Our goal was to investigate VT risk for different levels of prolactin... - Safety of thrombolysis in cerebral venous thrombosis. A systematic review of the literatureFrancesco Dentali
Internal Medicine, Department of Clinical Medicine, University of Insubria Ospedale di Circolo, Varese, Italy
Thromb Haemost 104:1055-62. 2010..Future studies are necessary to evaluate the safety of thrombolysis in comparison to more conservative strategies... - Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysisFrancesco Dentali
University of Insubria, Varese, Italy
Thromb Haemost 106:429-38. 2011..9-16.6). In conclusion, our results suggest there is a low but quantifiable risk of thromboembolism in VKA-treated patients receiving PCCs for anticoagulation reversal. These findings should be confirmed in randomised, controlled trials... - Weight gain after acute deep venous thrombosis: a prospective observational studyWalter Ageno
Department of Internal Medicine, Ospedale di Circolo, University of Insubria, Viale Borri 57, 21100 Varese, Italy
Thromb Res 109:31-5. 2003..Weight gain is strongly associated with an increase in metabolic and cardiovascular risk factors. The aim of this study was to assess weight changes occurring after an episode of acute deep venous thrombosis (DVT)... - Body mass index is associated with the development of the post-thrombotic syndromeWalter Ageno
Department of Internal Medicine, University of Insubria, Varese, Italy
Thromb Haemost 89:305-9. 2003..918 and p = 0.775, respectively). BMI is significantly correlated with the development of PTS. Patients with DVT should be encouraged to avoid weight gain. Reducing patient weight might be an important strategy to prevent PTS... - D-dimer is not a long-term prognostic marker following acute cerebral ischemiaAlessandro Squizzato
Department of Clinical Medicine, University of Insubria, Varese, Italy
Blood Coagul Fibrinolysis 17:303-6. 2006..50 microg/ml was not predictive of an increased risk of subsequent events. D-dimer levels measured in the acute phase after an acute cerebrovascular event probably do not predict the long-term clinical outcome... - The effect of hyperthyroidism on procoagulant, anticoagulant and fibrinolytic factors: a systematic review and meta-analysisDanka J F Stuijver
Department of Internal Medicine, Slotervaart Hospital, Louwesweg, Amsterdam, The Netherlands
Thromb Haemost 108:1077-88. 2012..We conclude that both subclinical and overt hyperthyroidism induce a prothrombotic state, which is therefore likely to be a risk factor for venous thrombosis... - Residual venous obstruction in patients with a single episode of deep vein thrombosis and in patients with recurrent deep vein thrombosisMatteo Galli
U.O. Medicina I, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
Thromb Haemost 94:93-5. 2005..00001). The prevalence of RVO is significantly higher in patients with recurrent DVT than in patients with a single episode. This finding supports the importance of RVO as a potential marker of a persistent prothrombotic state... - Incidence of chronic pulmonary hypertension in patients with previous pulmonary embolismFrancesco Dentali
Department of Clinical Medicine, Insubria University, Varese, Italy
Thromb Res 124:256-8. 2009..We therefore carried out a prospective cohort study to assess the incidence of CTPH diagnosed with echocardiography Doppler in consecutive patients with a first episode of PE... - Neutrophils and clinical outcomes in patients with acute coronary syndromes and/or cardiac revascularisation. A systematic review on more than 34,000 subjectsLuigina Guasti
Department of Clinical Medicine, University of Insubria, Varese, Italy
Thromb Haemost 106:591-9. 2011..The findings of our systematic review highlight the potential application of this inexpensive and readily available inflammatory marker for risk stratification in patients with ACS and/or cardiac revascularisation... - Epidemiology and risk factors of venous thromboembolismWalter Ageno
Department of Clinical Medicine, University of Insubria, Varese, Italy
Semin Thromb Hemost 32:651-8. 2006..The presence or absence of specific risk factors may play an important role in decisions about the type (and duration) of thromboprophylaxis/anticoagulation to be used... - Oral anticoagulant therapy in patients with mechanical heart valve and intracranial haemorrhage. A systematic reviewErica Romualdi
U O Medicina Interna I, Ospedale di Circolo, Viale Borri, 57, 21100 Varese, Italy
Thromb Haemost 101:290-7. 2009..However, well-designed studies are strongly recommended to provide better evidence... - Use of statins and recurrence of atrial fibrillation after catheter ablation or electrical cardioversion. A systematic review and meta-analysisFrancesco Dentali
Department of Clinical Medicine, University of Insubria, Varese, Italy
Thromb Haemost 106:363-70. 2011..20). In conclusion, statins may lower the risk of AF recurrence after electrical cardioversion, but not ablation. However, this finding should be considered with caution, and larger RCTs are warranted to confirm our preliminary results... - Application of a decision rule and a D-dimer assay in the diagnosis of pulmonary embolismNadine S Gibson
Department of Vascular Medicine, Academical Medical Center, Amsterdam, The Netherlands
Thromb Haemost 103:849-54. 2010..Furthermore, the knowledge of an abnormal D-dimer test result before seeing the patient leads to a higher CDR score. Physicians should therefore first examine patients before taking note of the D-dimer test result... - Hypercoagulable state in Cushing's syndrome: a systematic reviewBregje van Zaane
Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, Amsterdam, The Netherlands
J Clin Endocrinol Metab 94:2743-50. 2009..It has been debated whether an increased risk of venous thromboembolism (VTE) exists in patients with Cushing's syndrome... - Thrombosis prophylaxis in medical patients: a retrospective review of clinical practice patternsWalter Ageno
Department of Internal Medicine, University of Insubria, Italy
Haematologica 87:746-50; discussion 250. 2002..The risk of venous thromboembolism in medical patients is comparable to the risk in general surgical patients. Thromboprophylaxis is recommended for specific medical patients, but its use in clinical practice is unknown... - Prophylaxis and treatment of venous thromboembolism in patients with cancerWalter Ageno
Department of Clinical Medicine, University of Insubria, Varese, Italy
Intern Emerg Med 1:260-2. 2006 - JAK2V617F mutation for the early diagnosis of Ph- myeloproliferative neoplasms in patients with venous thromboembolism: a meta-analysisFrancesco Dentali
Department of Clinical Medicine, University of Insubria, Varese, Italy
Blood 113:5617-23. 2009..JAK2 mutation is strongly associated with SVT, and routine screening of JAK2 mutation appears to be indicated in these patients... - Polymorphisms of the Z protein protease inhibitor and risk of venous thromboembolism: a meta-analysisFrancesco Dentali
Department of Clinical Medicine, Insubria University, Varese, Italy
Br J Haematol 143:284-7. 2008..Five studies involving 5000 patients were included. R67X and W303X mutations of Serpina10 were not associated with increased VTE risk (OR 1.63; 95% CI 0.84, 3.16 and OR 1.21; 95% CI 0.29, 4.98 respectively)... - Thrombin-activatable fibrinolysis inhibitor in hypothyroidism and hyperthyroxinaemiaChantal J N Verkleij
Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Thromb Haemost 109:214-20. 2013..The disturbed haemostatic balance in patients with hyperthyroidism might make them prone to thrombosis, while the risk for bleeding may increase in patients with hypothyroidism... - The metabolic syndrome as a risk factor for venous and arterial thrombosisFrancesco Dentali
Department of Clinical Medicine, University of Insubria, Varese, Italy
Semin Thromb Hemost 35:451-7. 2009..A few recent studies suggest that the metabolic syndrome may also play a role in the pathogenesis of venous thromboembolism, but this latter finding needs confirmation by large clinical studies... - Antithrombotic therapy and cancerMarcello Di Nisio
Department of Vascular Medicine and of Oncology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Curr Opin Hematol 11:187-91. 2004..To assess the current evidence from recent clinical trials investigating antithrombotic agents for the prophylaxis and treatment of venous thromboembolism in cancer patients and for the effects of these agents on cancer progression... - Long-term outcomes of patients with cerebral vein thrombosis: a multicenter studyF Dentali
Department of Clinical Medicine, University of Insubria, Varese, Italy
J Thromb Haemost 10:1297-302. 2012..Little information is available on the long-term clinical outcome of cerebral vein thrombosis (CVT)... - Seasonal and monthly variability in the incidence of venous thromboembolism. A systematic review and a meta-analysis of the literatureFrancesco Dentali
Department of Clinical Medicine, University of Insubria, Varese, Italy
Thromb Haemost 106:439-47. 2011..Future studies are needed to better clarify the mechanisms behind this pattern... - D-dimer testing in ischemic stroke and cerebral sinus and venous thrombosisAlessandro Squizzato
Department of Internal Medicine 1, University of Insubria, Varese, Italy
Semin Vasc Med 5:379-86. 2005..However, more studies are needed to confirm these recent findings as well as management studies to correctly introduce D-dimer measurement in clinical daily practice of ischemic stroke and CSVT... - Selecting patients for home treatment of deep vein thrombosis: the problem of cancerWalter Ageno
Department of Internal Medicine University of Insubria, Varese, Italy
Haematologica 87:286-91. 2002..Cancer is frequently associated with venous thromboembolism and is often considered an exclusion criterion for outpatient treatment. We investigated the impact of cancer on the outpatient management of venous thrombosis... - Prevalence and clinical history of incidental, asymptomatic pulmonary embolism: a meta-analysisF Dentali
Department of Clinical Medicine, Insubria University, Varese, Italy
Thromb Res 125:518-22. 2010..Natural history of incidental PE remains unclear... - Prevalence of arterial and venous thromboembolic events in diabetic patients with and without the metabolic syndrome: a cross sectional studyF Dentali
Department of Clinical Medicine, University of Insubria, Varese, Italy
Thromb Res 127:299-302. 2011..The presence of MS was shown to further increase the risk of arterial cardiovascular diseases (CVD) in diabetic patients. Conversely, there are no studies that have compared the risk of VTE in diabetic patients with and without the MS... - An unusual case of cerebral vein thrombosis in a patient with giant cell arteritisMarco Donadini
Department of Clinical Medicine, University of Insubria, Varese, Italy
Thromb Haemost 100:513-4. 2008 - Antiplatelet drugs for polycythaemia vera and essential thrombocythaemiaAlessandro Squizzato
Research Center on Thromboembolic Disorders and Antithrombotic Therapies, Department of Clinical and Experimental Medicine, School of Medicine, University of Insubria, c o Medicina 1, Ospedale di Circolo, Viale Borri, 57, Varese, Italy, 21100
Cochrane Database Syst Rev 4:CD006503. 2013..In addition to the different therapeutic strategies available, an antiplatelet drug is often used to reduce thrombotic risk... - Clinical approach to splanchnic vein thrombosis: risk factors and treatmentNicoletta Riva
Research Center on Thromboembolic Diseases and Antithrombotic Therapies, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy
Thromb Res 130:S1-3. 2012..High quality evidence on the acute and long-term management is substantially lacking and the risk to benefit-ratio of anticoagulant therapy in SVT still needs to be better assessed... - Prophylaxis of venous thromboembolism following laparoscopic surgery: where is the evidence?W Ageno
University of Insubria, Internal Medicine, Varese, Italy
J Thromb Haemost 3:214-5. 2005 - Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular diseaseAlessandro Squizzato
Research Center on Thromboembolic Disorders and Antithrombotic Therapies, Department of Clinical Medicine, University of Insubria, Medicina 1, Viale Borri, 57, Varese, Italy, 21100
Cochrane Database Syst Rev 1:CD005158. 2011..Adding a second antiplatelet drug to aspirin may produce additional benefit for those at high risk and those with established cardiovascular disease... - Low dose oral vitamin K to reverse acenocoumarol-induced coagulopathy: a randomized controlled trialW Ageno
Department of Medicine, University of Insubria, Varese, Italy
Thromb Haemost 88:48-51. 2002..5 to 10.0. Furthermore, the use of a 1 mg dose of oral vitamin K results in an excessive risk of over-reversal of the INR... - Predictors of residual venous obstruction after deep vein thrombosis of the lower limbs: a prospective cohort studyW Ageno
Department of Internal Medicine, Ospedale di Circolo, University of Insubria, Varese, Italy
Thromb Res 108:203-7. 2002..Predictors of residual venous occlusion are unknown. We hypothesized that obesity, which causes reduced fibrinolytic activity, can predict delayed thrombus regression... - Abdominal obesity and the risk of recurrent deep vein thrombosisE Romualdi
Department of Clinical Medicine, University of Insubria, Varese, Italy
Thromb Res 119:687-90. 2007..Abdominal obesity has been found to be associated with an increased risk of deep vein thrombosis (DVT). Whether patients with abdominal obesity have an increased risk of recurrence is currently unknown... - Hypothyroidism and acquired von Willebrand's syndrome: a systematic reviewE Manfredi
Department of Clinical Medicine, University of Insubria, Varese, Italy
Haemophilia 14:423-33. 2008..Even if bleeding episodes are mainly mild and mucocutaneous, blood transfusion, drug administration or surgical procedure may be required... - [Current issues in the initial phase of warfarin therapy]Alessandro Squizzato
Recenti Prog Med 96:612-5. 2005..5-5 mg), and than patients following cardiopulmonary by-pass surgery. However, further clinical studies are necessary to identify the best strategy to individualize warfarin initiation therapy... - Tailoring warfarin induction doses to reflect individual and disease-specific factorsWalter Ageno
Am J Med 118:143-4. 2005 - What is the next step in D-dimer research? Education of physiciansAlessandro Squizzato
Intern Emerg Med 1:165. 2006 - Pharmacological thromboprophylaxis in acutely ill medical patients: some work remains to be doneMatteo Galli
Rev Assoc Med Bras 52:376-7. 2006 - Statins and secondary prevention of ischemic and hemorrhagic strokeAlessandro Squizzato
Stroke 39:e113; author reply e114. 2008