Edgardo Somigliana

Summary

Country: Italy

Publications

  1. ncbi request reprint Damage to ovarian reserve associated with laparoscopic excision of endometriomas: a quantitative rather than a qualitative injury
    Guido Ragni
    Infertility Unit, Policlinico, Mangiagalli and Regina Elena Hospital, Universita degli Studi di Milano, Milan, Italy
    Am J Obstet Gynecol 193:1908-14. 2005
  2. ncbi request reprint Does laparoscopic excision of endometriotic ovarian cysts significantly affect ovarian reserve? Insights from IVF cycles
    E Somigliana
    Infertility Unit, Department of Obstetrics and Gynecology, Clinica L Mangiagalli, University of Milan, Milan, Italy
    Hum Reprod 18:2450-3. 2003
  3. ncbi request reprint Bladder endometriosis: getting closer and closer to the unifying metastatic hypothesis
    Edgardo Somigliana
    Department of Obstetrics and Gynecology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Fertil Steril 87:1287-90. 2007
  4. ncbi request reprint Postoperative medical therapy after surgical treatment of endometriosis: from adjuvant therapy to tertiary prevention
    Edgardo Somigliana
    Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy Electronic address
    J Minim Invasive Gynecol 21:328-34. 2014
  5. pmc Clomiphene citrate versus high doses of gonadotropins for in vitro fertilisation in women with compromised ovarian reserve: a randomised controlled non-inferiority trial
    Guido Ragni
    Infertility Unit, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Reprod Biol Endocrinol 10:114. 2012
  6. doi request reprint Endometriosis in a rural remote setting: a cross-sectional study
    Edgardo Somigliana
    Doctors with Africa CUAMM, Padova, Italy
    Gynecol Endocrinol 28:979-82. 2012
  7. doi request reprint Surgical excision of endometriomas and ovarian reserve: a systematic review on serum antimüllerian hormone level modifications
    Edgardo Somigliana
    Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Fertil Steril 98:1531-8. 2012
  8. doi request reprint Adhesion prevention in endometriosis: a neglected critical challenge
    Edgardo Somigliana
    Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    J Minim Invasive Gynecol 19:415-21. 2012
  9. ncbi request reprint Treatment of endometriosis-related pain: options and outcomes
    Edgardo Somigliana
    Department of Obstetrics and Gynecology, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Front Biosci (Elite Ed) 1:455-65. 2009
  10. ncbi request reprint Association rate between deep peritoneal endometriosis and other forms of the disease: pathogenetic implications
    Edgardo Somigliana
    II Department of Obstetrics and Gynecology, Clinica L Mangiagalli, University of Milan, Milan, Italy
    Hum Reprod 19:168-71. 2004

Detail Information

Publications118 found, 100 shown here

  1. ncbi request reprint Damage to ovarian reserve associated with laparoscopic excision of endometriomas: a quantitative rather than a qualitative injury
    Guido Ragni
    Infertility Unit, Policlinico, Mangiagalli and Regina Elena Hospital, Universita degli Studi di Milano, Milan, Italy
    Am J Obstet Gynecol 193:1908-14. 2005
    ....
  2. ncbi request reprint Does laparoscopic excision of endometriotic ovarian cysts significantly affect ovarian reserve? Insights from IVF cycles
    E Somigliana
    Infertility Unit, Department of Obstetrics and Gynecology, Clinica L Mangiagalli, University of Milan, Milan, Italy
    Hum Reprod 18:2450-3. 2003
    ..Ultrasonographic evaluation of ovarian response to ovulation stimulation represents a simple yet poorly employed tool to assess residual ovarian function after surgery...
  3. ncbi request reprint Bladder endometriosis: getting closer and closer to the unifying metastatic hypothesis
    Edgardo Somigliana
    Department of Obstetrics and Gynecology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Fertil Steril 87:1287-90. 2007
    ..The aim of the study was to evaluate the presence of other forms of endometriosis in patients with bladder endometriotic nodules...
  4. ncbi request reprint Postoperative medical therapy after surgical treatment of endometriosis: from adjuvant therapy to tertiary prevention
    Edgardo Somigliana
    Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy Electronic address
    J Minim Invasive Gynecol 21:328-34. 2014
    ..Further evidence is warranted to better delineate the beneficial effects of this emerging but convincing strategy...
  5. pmc Clomiphene citrate versus high doses of gonadotropins for in vitro fertilisation in women with compromised ovarian reserve: a randomised controlled non-inferiority trial
    Guido Ragni
    Infertility Unit, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Reprod Biol Endocrinol 10:114. 2012
    ....
  6. doi request reprint Endometriosis in a rural remote setting: a cross-sectional study
    Edgardo Somigliana
    Doctors with Africa CUAMM, Padova, Italy
    Gynecol Endocrinol 28:979-82. 2012
    ....
  7. doi request reprint Surgical excision of endometriomas and ovarian reserve: a systematic review on serum antimüllerian hormone level modifications
    Edgardo Somigliana
    Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Fertil Steril 98:1531-8. 2012
    ..To evaluate serum antimüllerian hormone (AMH) level modification after surgical excision of ovarian endometriomas...
  8. doi request reprint Adhesion prevention in endometriosis: a neglected critical challenge
    Edgardo Somigliana
    Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    J Minim Invasive Gynecol 19:415-21. 2012
    ..Future studies should focus on a 2-step strategy that includes measures applied at the time of surgery and subsequent administration of agents able to prevent the development of new adhesions...
  9. ncbi request reprint Treatment of endometriosis-related pain: options and outcomes
    Edgardo Somigliana
    Department of Obstetrics and Gynecology, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Front Biosci (Elite Ed) 1:455-65. 2009
    ....
  10. ncbi request reprint Association rate between deep peritoneal endometriosis and other forms of the disease: pathogenetic implications
    Edgardo Somigliana
    II Department of Obstetrics and Gynecology, Clinica L Mangiagalli, University of Milan, Milan, Italy
    Hum Reprod 19:168-71. 2004
    ..In this study, we hypothesize that, if this is true, deep peritoneal endometriosis and the other forms should not be significantly associated...
  11. doi request reprint Surgical measures for endometriosis-related infertility: a plea for research
    E Somigliana
    Dept Obset Gynecol, Fondazione Cà Granda, Ospedale Maggiore Policlinico, Via Commenda 12, 20122 Milan, Italy
    Placenta 32:S238-42. 2011
    ..However, available studies are mainly based on II look laparoscopies performed few weeks after the intervention and data on fertility is lacking. Clinical trials including pregnancy rate as a specific outcome are warranted...
  12. doi request reprint Endometriosis and estroprogestins: the chicken or the egg causality dilemma
    Edgardo Somigliana
    Department of Obstetrics, Gynecology, and Neonatology, Fondazione Cà Granda, Milan, Italy
    Fertil Steril 95:431-3. 2011
    ..This might explain the previously reported mild association between endometriosis and past use of oral contraceptives...
  13. doi request reprint The use and effectiveness of in vitro fertilization in women with endometriosis: the surgeon's perspective
    Edgardo Somigliana
    Department of Obstetrics and Gynecology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Fertil Steril 91:1775-9. 2009
    ..To assess the use and effectiveness of IVF in a cohort of women undergoing surgery for endometriosis...
  14. doi request reprint Recurrent endometrioma and ovarian reserve: biological connection or surgical paradox?
    Edgardo Somigliana
    Department of Obstetrics, Gynecology, and Neonatology, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Am J Obstet Gynecol 204:529.e1-5. 2011
    ..On these bases, we have hypothesized that the risk of recurrence may be related to the residual ovarian reserve of the operated ovary...
  15. ncbi request reprint Should endometriomas be treated before IVF-ICSI cycles?
    Edgardo Somigliana
    Department of Obstetrics, Gynecology and Neonatology, Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    Hum Reprod Update 12:57-64. 2006
    ..Alternative therapeutical options include medical treatment and ultrasound-guided aspiration. Whereas prolonged GnRH agonist down-regulation may be beneficial, data on ultrasound aspiration are more controversial...
  16. doi request reprint The role of myomectomy in fertility enhancement
    Edgardo Somigliana
    Department of Obstetrics and Gynecology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Curr Opin Obstet Gynecol 20:379-85. 2008
    ..Pregnancy complications related to the presence of these lesions and to their removal are also addressed...
  17. ncbi request reprint Discontinuing combination antiretroviral therapy during the first trimester of pregnancy: insights from plasma human immunodeficiency virus-1 RNA viral load and CD4 cell count
    A M Bucceri
    II Department of Obstetrics and Gynecology, Clinica L Mangiagalli, University of Milan, Italy
    Am J Obstet Gynecol 189:545-51. 2003
    ..These two strategies are compared in terms of plasma human immunodeficiency virus viral load and CD4 cell count...
  18. doi request reprint A comprehensive and integrated project to improve reproductive health at Oyam district, northern Uganda: insights from maternal death review at the district hospital
    Edgardo Somigliana
    Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Arch Gynecol Obstet 283:645-9. 2011
    ..To perform a district hospital-based maternal death review aimed at assessing the benefits and limits of an integrated and comprehensive project for reproductive health in Oyam district, northern Uganda...
  19. ncbi request reprint Vitamin D reserve is higher in women with endometriosis
    Edgardo Somigliana
    Infertility Unit, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via M Fanti 6, 20122 Milan, Italy
    Hum Reprod 22:2273-8. 2007
    ..Since vitamin D is an effective modulator of the immune system, we have hypothesized that the vitamin D status may have a role in the pathogenesis of endometriosis...
  20. ncbi request reprint Combination antiretroviral therapy in 100 HIV-1-infected pregnant women
    A M Bucceri
    II Department of Obstetrics and Gynecology, University of Milan, Milano, Italy
    Hum Reprod 17:436-41. 2002
    ..However, at present, information regarding the effects of these regimens during pregnancy is limited...
  21. ncbi request reprint The presence of ovarian endometriomas is associated with a reduced responsiveness to gonadotropins
    Edgardo Somigliana
    Infertility Unit, Department of Obstetrics, Gynecology and Neonatology, Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    Fertil Steril 86:192-6. 2006
    ..To clarify whether the presence of ovarian endometriomas is associated with a reduced responsiveness to ovarian hyperstimulation...
  22. ncbi request reprint Ambulance service within a comprehensive intervention for reproductive health in remote settings: a cost-effective intervention
    Edgardo Somigliana
    Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Trop Med Int Health 16:1151-8. 2011
    ..To assess the cost-effectiveness of an ambulance service within a comprehensive hospital/community-based program aimed at improving access and quality of reproductive health in poor-resources settings...
  23. ncbi request reprint Does laparoscopic removal of nonendometriotic benign ovarian cysts affect ovarian reserve?
    Edgardo Somigliana
    Infertility Unit, Department of Obstetrics and Gynecology, Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    Acta Obstet Gynecol Scand 85:74-7. 2006
    ..The objective of this study was to investigate whether laparoscopic excision of nonendometriotic benign ovarian cysts is associated with a significant injury to ovarian reserve...
  24. doi request reprint Perinatal environment and endometriosis
    Edgardo Somigliana
    Department of Obstetrics, Gynecology and Neonatology, Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Gynecol Obstet Invest 72:135-40. 2011
    ..Perinatal environmental exposure may affect fetal development and reprogram the developing organism for adult-onset disease. In this case-control study, we aimed at assessing this pathogenetic model in endometriosis...
  25. ncbi request reprint Use of the concomitant serum dosage of CA 125, CA 19-9 and interleukin-6 to detect the presence of endometriosis. Results from a series of reproductive age women undergoing laparoscopic surgery for benign gynaecological conditions
    E Somigliana
    Department of Obstetrics and Gynecology, Clinica L Mangiagalli, University of Milano, Italy
    Hum Reprod 19:1871-6. 2004
    ..This study was performed in order to verify the clinical value of serum CA 125, CA 19-9 and IL-6 levels, either by themselves or combined, in the detection of the disease...
  26. doi request reprint Effect of delaying post-operative conception after conservative surgery for endometriosis
    Edgardo Somigliana
    Department of Obstetrics and Gynecology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Reprod Biomed Online 20:410-5. 2010
    ..However, these differences did not reach statistical significance and this advice is thus not mandatory. Larger studies are warranted to validate these conclusions...
  27. doi request reprint Attractiveness of women with rectovaginal endometriosis: a case-control study
    Paolo Vercellini
    Clinica Ostetrica e Ginecologica, Istituto Luigi Mangiagalli, Universita degli Studi, and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Fertil Steril 99:212-8. 2013
    ..To evaluate physical attractiveness in women with and without endometriosis...
  28. doi request reprint Medical treatment for rectovaginal endometriosis: what is the evidence?
    Paolo Vercellini
    Department of Obstetrics and Gynaecology, Istituto Luigi Mangiagalli, University of Milan, Via Commenda 12, 20122 Milan, Italy
    Hum Reprod 24:2504-14. 2009
    ..Surgical treatment may be effective but is associated with a high risk of morbidity and major complications. Information on the effect of medical alternatives for pain relief in this condition is scarce...
  29. ncbi request reprint The vascular endothelial growth factor +405G>C polymorphism in endometriosis
    Davide Gentilini
    Molecular Biology Laboratory, Istituto Auxologico Italiano, Cusano Milanino, Milan, Italy
    Hum Reprod 23:211-5. 2008
    ..The aim of this study was to investigate the potential association between the single nucleotide polymorphism +405G>C of the VEGF gene with the risk of endometriosis, for the first time in the Caucasian population...
  30. doi request reprint Surgery for endometriosis-associated infertility: a pragmatic approach
    Paolo Vercellini
    Gynaecologic Surgery Division, Department of Obstetrics and Gynaecology, University of Milan, Via Commenda 12, 20122 Milano, Italy
    Hum Reprod 24:254-69. 2009
    ..Complete and detailed information on risks and benefits of treatment alternatives must be offered to infertile patients to allow unbiased choices between possible options...
  31. doi request reprint The second time around: reproductive performance after repetitive versus primary surgery for endometriosis
    Paolo Vercellini
    Division of Gynecologic Surgery, Istituto Ostetrico e Ginecologico Luigi Mangiagalli, Universita degli Studi di Milano, Milan, Italy
    Fertil Steril 92:1253-5. 2009
    ..55; 95% confidence interval, 0.30 to 0.99), and the 12- and 24-month cumulative pregnancy rates were 13% and 22% in the former group and 25% and 30% in the latter...
  32. ncbi request reprint Genetics of endometriosis: a role for the progesterone receptor gene polymorphism PROGINS?
    Debora Lattuada
    Molecular Biology Laboratory, Istituto Auxologico Italiano, University of Milan, Milan, Italy
    Clin Endocrinol (Oxf) 61:190-4. 2004
    ....
  33. ncbi request reprint Ovarian endometriomas and oocyte quality: insights from in vitro fertilization cycles
    Francesca Filippi
    Department of Obstetrics and Gynecology, Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy Electronic address
    Fertil Steril 101:988-93.e1. 2014
    ..To evaluate whether the presence of endometriomas affects ovarian function...
  34. doi request reprint Role of surgery in endometriosis-associated subfertility
    Nicola Berlanda
    Clinica Ostetrica e Ginecologica, Istituto Luigi Mangiagalli, Università Statale di Milano, Milano, Italy
    Semin Reprod Med 31:133-43. 2013
    ..The role of surgery in endometriosis-associated subfertility includes temporary pain relief in symptomatic women desiring a spontaneous conception...
  35. doi request reprint Effect of patient selection on estimate of reproductive success after surgery for rectovaginal endometriosis: literature review
    Paolo Vercellini
    Department of Obstetrics and Gynecology, Istituto Luigi Mangiagalli, University of Milan, Milan, Italy
    Reprod Biomed Online 24:389-95. 2012
    ..The 15% difference is statistically significant. Infertile patients with rectovaginal endometriosis considering surgery, should be carefully informed of the real probability of post-operative conception avoiding generic overestimations...
  36. doi request reprint Rate of severe ovarian damage following surgery for endometriomas
    Laura Benaglia
    Infertility Unit, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via M Fanti 6, 20122 Milan, Italy
    Hum Reprod 25:678-82. 2010
    ..Of particular concern is the risk of severe ovarian damage leading to unresponsiveness to ovarian hyperstimulation. In this study, we aimed to determine the rate of this complication...
  37. doi request reprint The impact of IVF procedures on endometriosis recurrence
    Laura Benaglia
    Infertility Unit, Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    Eur J Obstet Gynecol Reprod Biol 148:49-52. 2010
    ..Thus, since available data on this issue are scanty and controversial, an observational study has been herein conducted in order to clarify this issue...
  38. doi request reprint The effect of second-line surgery on reproductive performance of women with recurrent endometriosis: a systematic review
    Paolo Vercellini
    Department of Obstetrics and Gynecology, University of Milan, Milan, Italy
    Acta Obstet Gynecol Scand 88:1074-82. 2009
    ..58-3.91%). Conclusions. The probability of conception after repeat surgery for recurrent endometriosis appeared limited and reduced compared with that after primary surgery. The results of IVF were not inferior to those of reoperation...
  39. doi request reprint Plasminogen activator inhibitor-1 4G/5G polymorphism and susceptibility to endometriosis in the Italian population
    Davide Gentilini
    Molecular Biology Laboratory, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Eur J Obstet Gynecol Reprod Biol 146:219-21. 2009
    ..To clarify this issue, we have examined the prevalence of this polymorphism in a case-control study in the Italian population...
  40. doi request reprint High rate of endometriosis recurrence in young women
    Iacopo Tandoi
    Obstetrics and Gynecology Unit, Scientific Institute San Raffaele, Milano, Italy
    J Pediatr Adolesc Gynecol 24:376-9. 2011
    ..To evaluate rate and determinants of long-term recurrence of endometriosis in a population of young women...
  41. doi request reprint Fibroids not encroaching the endometrial cavity and IVF success rate: a prospective study
    Edgardo Somigliana
    Department of Obset Gynecol Fondazione Cà Granda, Ospedale Maggiore Policlinico, Via Commenda 12, 20122 Milano, Italy
    Hum Reprod 26:834-9. 2011
    ..CONCLUSIONS In asymptomatic patients selected for IVF, small fibroids not encroaching the endometrial cavity did not impact on the rate of success of the procedure...
  42. doi request reprint Repetitive surgery for recurrent symptomatic endometriosis: what to do?
    Paolo Vercellini
    Department of Obstetrics and Gynaecology, University of Milan, Istituto Luigi Mangiagalli, Via Commenda 12 20122 Milan, Italy
    Eur J Obstet Gynecol Reprod Biol 146:15-21. 2009
    ..Studies on surgical management of recurrent rectovaginal endometriosis are warranted, due to the peculiar technical difficulties as well as the high risk of complications associated with this challenging disease form...
  43. ncbi request reprint Genetic screening in 2,710 infertile candidate couples for assisted reproductive techniques: results of application of Italian guidelines for the appropriate use of genetic tests
    Alessandra Riccaboni
    Infertility Unit, Fondazione Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    Fertil Steril 89:800-8. 2008
    ..The guidelines recommend performing a karyotype analysis in each couple and the screening test for mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) in one of the two partners...
  44. doi request reprint Hyperstimulation during IVF cycles does not modify dimensions of small subserosal and intramural leiomyomas
    Laura Benaglia
    Infertility Unit, Fondazione Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milan, Italy
    Fertil Steril 95:2489-91. 2011
    ..The mean ± SD diameters of the tumors at these two time points were 20.5 ± 9.5 and 20.6 ± 10.2 mm, respectively, thus supporting the conclusion that IVF does not influence the growth of these lesions...
  45. ncbi request reprint Postoperative oral contraceptive exposure and risk of endometrioma recurrence
    Paolo Vercellini
    Department of Obstetrics and Gynecology, University of Milan, Milan, Italy
    Am J Obstet Gynecol 198:504.e1-5. 2008
    ..The purpose of this study was to compare the postoperative risk of endometrioma recurrence in women using oral contraception and in those undergoing simple observation...
  46. doi request reprint In vitro fertilization outcomes in treated hypothyroidism
    Andrea Busnelli
    1 Department of Obstetrics and Gynecology, Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Thyroid 23:1319-25. 2013
    ..In particular, it has yet to be clarified whether levothyroxine may fully overcome the detrimental effects of hypothyroidism or, conversely, whether affected women remain at reduced prognosis for pregnancy outcomes...
  47. doi request reprint The vanishing endometrioma: the intriguing impact of pregnancy on small endometriotic ovarian cysts
    Laura Benaglia
    Department of Obstet Gynecol, Infertility Unit, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy
    Gynecol Endocrinol 29:863-6. 2013
    ..A consistent proportion of cysts becomes undetectable after delivery. Further studies are warranted to clarify the mechanisms determining the disappearance of these cysts...
  48. doi request reprint IVF and endometriosis-related symptom progression: insights from a prospective study
    Laura Benaglia
    Infertility Unit, Department of Obstetrics and Gynecology, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via M Fanti, 6, 20122 Milan, Italy
    Hum Reprod 26:2368-72. 2011
    ..A possible and neglected concern in women with endometriosis undergoing IVF is the potential risk of progression of the disease. We set up a prospective study mainly aimed at evaluating the impact of IVF on endometriosis-related symptoms...
  49. doi request reprint Pregnancy outcome in women with endometriomas achieving pregnancy through IVF
    Laura Benaglia
    Department of Obstetrics and Gynecology, Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Hum Reprod 27:1663-7. 2012
    ..There is a growing consensus that ovarian endometriomas should not be systematically removed in women selected for IVF. However, some recent evidence suggested that the presence of these cysts may negatively affect the course of pregnancy...
  50. doi request reprint The long pentraxin 3 is a soluble and cell-associated component of the human semen
    Andrea Doni
    Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Int J Androl 32:255-64. 2009
    ..Moreover, PTX3 binds to spermatozoa, in particular with immotile cells, localizing in the neck and in the subacrosomial region. Finally, recombinant PTX3 did not interfere with sperm motility...
  51. doi request reprint Vitamin D status in women with uterine leiomyomas
    Alessio Paffoni
    Fondazione Cà Granda, Ospedale Maggiore Policlinico, Infertility Unit, via Fanti 6, 20122 Milano, Italy
    J Clin Endocrinol Metab 98:E1374-8. 2013
    ..Recent in vitro and in vivo experimental evidence supports a role of vitamin D insufficiency as an important factor in the development of uterine leiomyomas. However, epidemiological data supporting this possibility are scanty...
  52. doi request reprint In vitro fertilization outcome in women with unoperated bilateral endometriomas
    Laura Benaglia
    Department of Obstetrics and Gynecology, Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Fertil Steril 99:1714-9. 2013
    ..To evaluate IVF outcome in women with unoperated bilateral endometriomas...
  53. doi request reprint Confined placental mosaicism at chorionic villous sampling: risk factors and pregnancy outcome
    Giulia Maria Baffero
    Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Prenat Diagn 32:1102-8. 2012
    ..This study aims to investigate the clinical relevance of confined placental mosaicism (CPM) detected at chorionic villous sampling (CVS) and to identify risk factors for this condition...
  54. doi request reprint Predicting factors for emergency peripartum hysterectomy in women with placenta previa
    Erika Giambattista
    Department Obstet Gynaecol, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Commenda, 12, 20122 Milan, Italy
    Arch Gynecol Obstet 285:901-6. 2012
    ..The aim of the study was to identify predictive factors for peripartum hysterectomy in women with placenta previa...
  55. doi request reprint "I can't get no satisfaction": deep dyspareunia and sexual functioning in women with rectovaginal endometriosis
    Paolo Vercellini
    Clinica Ostetrica e Ginecologica, Istituto Luigi Mangiagalli, Università Statale di Milano, Milan, Italy
    Fertil Steril 98:1503-11.e1. 2012
    ..To assess the impact of rectovaginal endometriosis on pain at intercourse and sexual functioning...
  56. ncbi request reprint Post-operative endometriosis recurrence: a plea for prevention based on pathogenetic, epidemiological and clinical evidence
    Paolo Vercellini
    Department of Obstetrics and Gynaecology, University of Milan and Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Reprod Biomed Online 21:259-65. 2010
    ..16 (95% CI 0.04-0.65). After first-line surgery for endometriosis, women should be invited to seek conception as soon as possible. Alternatively, oral contraceptive use until pregnancy is desired should be considered...
  57. doi request reprint Endometriosis: current therapies and new pharmacological developments
    Paolo Vercellini
    Clinica Ostetrica e Ginecologica I, University of Milan, Milan, Italy
    Drugs 69:649-75. 2009
    ..Finally, as reproductive prognosis is not ameliorated by medical treatment, it is not indicated for women seeking conception...
  58. ncbi request reprint Preventing high-order multiple pregnancies during controlled ovarian hyperstimulation and intrauterine insemination: 3 years' experience using low-dose recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists
    Guido Ragni
    Department of Obstetrics Gynecology, Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Italy
    Fertil Steril 85:619-24. 2006
    ..To employ protocols of mild ovarian stimulation to prevent an excessively elevated rate of high-order multiple pregnancies...
  59. doi request reprint 'Here comes the sun': pigmentary traits and sun habits in women with endometriosis
    Edgardo Somigliana
    Department of Obstetrics, Gynecology and Neonatology, Fondazione Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    Hum Reprod 25:728-33. 2010
    ..There is limited but interesting evidence suggesting that endometriosis may be associated with specific pigmentary traits and sun habits. In this case-control study, we aimed to further clarify this point...
  60. doi request reprint Unoperated ovarian endometriomas and responsiveness to hyperstimulation
    Laura Benaglia
    Department of Obstetrics, Gynecology and Neonatology, Fondazione Cà Granda, Ospedale Maggiore Policlinico, Via M Fanti, 6, 20122 Milan, Italy
    Hum Reprod 26:1356-61. 2011
    ..The main aim of this study was to compare the number of developing follicles in the affected ovary with that in the contralateral intact gonad as a control...
  61. ncbi request reprint IVF-ICSI outcome in women operated on for bilateral endometriomas
    Edgardo Somigliana
    Infertility Unit, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via M Fanti 6, 20122 Milan, Italy
    Hum Reprod 23:1526-30. 2008
    ..The contralateral intact ovary may adequately supply for the reduced function of the affected one. To clarify this point, we assess IVF-ICSI outcome in women operated on for bilateral endometriomas...
  62. ncbi request reprint Predictive factors for neonatal survival in women with periviable preterm rupture of the membranes
    Barbara Acaia
    Department of Obstetrics and Gynecology, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico
    J Matern Fetal Neonatal Med 26:1628-34. 2013
    ..To identify clinical, hematological or instrumental factors available at the time of the diagnosis that may predict neonatal survival in periviable preterm premature rupture of the membranes (PROM)...
  63. ncbi request reprint Endometriosis: epidemiology and aetiological factors
    Paola Vigano
    Second Department of Obstetrics and Gynecology and Istituto Auxologico Italiano, Cusano Milanino, University of Milan, Milano, Italy
    Best Pract Res Clin Obstet Gynaecol 18:177-200. 2004
    ....
  64. doi request reprint Long-term adjuvant therapy for the prevention of postoperative endometrioma recurrence: a systematic review and meta-analysis
    Paolo Vercellini
    Department of Obstetrics and Gynecology, University of Milan and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Acta Obstet Gynecol Scand 92:8-16. 2013
    ..11-0.40) and 0.39 (95% confidence interval 0.23-0.66). Postoperative OC use dramatically decreased the risk of ovarian endometrioma recurrence, especially in women who used OCs regularly and for prolonged periods...
  65. doi request reprint Endometriotic ovarian cysts negatively affect the rate of spontaneous ovulation
    Laura Benaglia
    Infertility Unit, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via M Fanti 6, 20122 Milan, Italy
    Hum Reprod 24:2183-6. 2009
    ..To clarify this aspect, we set up a prospective study in women with monolateral endometriomas in order to assess the rate of ovulation in affected ovaries...
  66. ncbi request reprint Endometriosis: novel etiopathogenetic concepts and clinical perspectives
    Mario Vignali
    IRCCS Istituto Auxologico Italiano, Milan, Italy
    Fertil Steril 78:665-78. 2002
    ..To discuss current ideas about therapy for endometriosis derived from new observations generated by using molecular biology techniques and in vivo animal models of disease...
  67. ncbi request reprint Variants of the CTLA4 gene that segregate with autoimmune diseases are not associated with endometriosis
    Paola Vigano
    Department of Obstetrics, Gynaecology and Neonatology, Fondazione Policlinico Mangiagalli Regina Elena Hospital, University of Milano, Italy
    Mol Hum Reprod 11:745-9. 2005
    ..These findings suggest that endometriosis aetiology is not primarily associated with the development of CTLA4-linked autoimmunity...
  68. ncbi request reprint Endometriosis: current and future medical therapies
    Paolo Vercellini
    Clinica Ostetrica e Ginecologica II, University of Milan, Istituto Luigi Mangiagalli, Via Commenda, Milan, Italy
    Best Pract Res Clin Obstet Gynaecol 22:275-306. 2008
    ..Medical treatment is not indicated in women seeking conception because reproductive prognosis is not ameliorated...
  69. ncbi request reprint Association between endometriosis and cancer: a comprehensive review and a critical analysis of clinical and epidemiological evidence
    Edgardo Somigliana
    Department of Obstetrics, Gynecology and Neonatology, Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Via Commenda 12, 20122 Milan, Italy
    Gynecol Oncol 101:331-41. 2006
    ..Based on the observations herein presented, clinical indications that might avoid physicians' mismanaging of affected patients are proposed...
  70. ncbi request reprint Developmental potential of human oocytes after slow freezing or vitrification: a randomized in vitro study based on parthenogenesis
    Alessio Paffoni
    Department of Obstetrics, Gynaecology, and Neonatology, Infertility Unit, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Reprod Sci 15:1027-33. 2008
    ..8 + 1.9 vs. 5.8 + 1.7). In conclusion, parthenogenesis highlights a reduced potential of vitrified oocytes to cleave on day 3 compared with oocytes from slow-freezing...
  71. ncbi request reprint Postsurgical ovarian failure after laparoscopic excision of bilateral endometriomas
    Mauro Busacca
    Department of Obstetrics and Gynecology, Ospedale Macedonio Melloni, Milan, Italy
    Am J Obstet Gynecol 195:421-5. 2006
    ..This study was undertaken to determine the frequency of postsurgical ovarian failure in patients undergoing laparoscopic excision of bilateral endometriomas...
  72. doi request reprint Comparison of contraceptive ring and patch for the treatment of symptomatic endometriosis
    Paolo Vercellini
    Istituto Ostetrico e Ginecologico Luigi Mangiagalli, Universita degli Studi di Milano, 20122 Milan, Italy
    Fertil Steril 93:2150-61. 2010
    ..To evaluate the efficacy and tolerability of a contraceptive vaginal ring and transdermal patch in the treatment of endometriosis-associated pain...
  73. ncbi request reprint Is the dimension of ovarian endometriomas significantly modified by IVF-ICSI cycles?
    Laura Benaglia
    Infertility Unit, Fondazione Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    Reprod Biomed Online 18:401-6. 2009
    ..The development of a new endometrioma was documented in one case (2.1%, 95% confidence interval 0.1-11.1%). Fear about the growth of ovarian endometriomas in women who have to undergo IVF-ICSI is not justified...
  74. ncbi request reprint New drugs in development for the treatment of endometriosis
    Luigi Fedele
    Fondazione IRCCS Ospedale Maggiore Policlinico, Obstetrics and Gynecology, Mangiagalli e Regina Elena, Via Commenda 12, 20122 Milano, Italy
    Expert Opin Investig Drugs 17:1187-202. 2008
    ..Results show appealing new possibilities are emerging from agents counteracting the endometriosis-associated inflammation. Recent data also suggests that there is still the opportunity to refine the use of already available agents...
  75. ncbi request reprint Ovarian recovery after laparoscopic enucleation of ovarian cysts: insights from echographic short-term postsurgical follow-up
    Massimo Candiani
    Department of Obstetrics, Gynecology and Neonatology, Policlinico, L Mangiagalli Hospital, and Universita degli Studi di Milano, Milan, Italy
    J Minim Invasive Gynecol 12:409-14. 2005
    ..To evaluate damage to ovarian reserve following laparoscopic cystectomy of benign ovarian cysts...
  76. doi request reprint The clomiphene citrate challenge test (CCCT) in women with elevated basal FSH: biological significance and predictive value
    Guido Ragni
    Infertility Unit, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Eur J Obstet Gynecol Reprod Biol 141:44-8. 2008
    ..Biological evidence supporting this assumption is, however, lacking. The aim of this study is to investigate the relationship between results from the CCCT and the quantity and the quality of the recruited oocytes...
  77. ncbi request reprint Reproductive prognosis in male patients with azoospermia at the time of cancer diagnosis
    Guido Ragni
    Department of Obstetrics and Gynecology, University of Milan, Milan, Italy
    Fertil Steril 83:1674-9. 2005
    ..Fertility status evaluation in patients found azoospermic at the time of malignancy diagnosis...
  78. doi request reprint Chronic pelvic pain in women: etiology, pathogenesis and diagnostic approach
    Paolo Vercellini
    Clinica Ostetrica e Ginecologica I, University of Milan, Milan, Italy
    Gynecol Endocrinol 25:149-58. 2009
    ..CPP is a symptom, not a disease, and rarely reflects a single pathologic process. Gaining women's trust and developing a strong patient-physician relationship is of utmost importance for the long-term outcome of care...
  79. ncbi request reprint Follicular fluid levels of the long pentraxin PTX3
    Alessio Paffoni
    Department of Obstetrics, Gynecology, and Neonatology, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    J Soc Gynecol Investig 13:226-31. 2006
    ....
  80. doi request reprint Endometrioma and oocyte retrieval-induced pelvic abscess: a clinical concern or an exceptional complication?
    Laura Benaglia
    Infertility Unit, Department of Obstetrics and Gynecology, Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    Fertil Steril 89:1263-6. 2008
    ..This complication was never recorded, indicating that its risk is very low (0.0; 95% confidence interval, 0.0-1.7%)...
  81. ncbi request reprint The role of the levonorgestrel-releasing intrauterine device in the management of symptomatic endometriosis
    Paolo Vercellini
    Obstetrics and Gynecology Clinic, Luigi Mangiagalli Institute, University of Milan, Milan, Italy
    Curr Opin Obstet Gynecol 17:359-65. 2005
    ..The aim of this article is to evaluate the biological rationale for the use of an intrauterine device releasing 20 mug/day of levonorgestrel in women with endometriosis, and to assess its efficacy in relieving pelvic pain symptoms...
  82. ncbi request reprint A randomized comparison of tension-free vaginal tape and endopelvic fascia plication in women with genital prolapse and occult stress urinary incontinence
    Michele Meschia
    Department of Obstetrics and Gynecology, Urogynecology Unit, University of Milan, Milano, Italy
    Am J Obstet Gynecol 190:609-13. 2004
    ..The purpose of this study was to compare 2 anti-incontinence procedures in women who had severe genital prolapse and potential stress incontinence...
  83. ncbi request reprint Bias versus causality: interpreting recent evidence of association between endometriosis and ovarian cancer
    Paola Vigano
    Department of Obstetrics and Gynecology, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Fertil Steril 88:588-93. 2007
    ..To establish whether causality versus biases may explain the association of endometriosis and ovarian cancer...
  84. ncbi request reprint Non-invasive diagnosis of endometriosis: the goal or own goal?
    Edgardo Somigliana
    Department of Obstetrics, Gynecology and Neonatology, Fondazione Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    Hum Reprod 25:1863-8. 2010
    ..In particular, we emphasize that this instrument may be of benefit provided that the test is not used as a screening test...
  85. ncbi request reprint Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriosis: a critical analysis
    Paola Vigano
    Department of Obstetrics, Gynecology and Neonatology, Fondazione Policlinico Mangiagalli Regina Elena, Milan, Italy
    Hum Reprod Update 12:77-89. 2006
    ..Based on these data, the causal link between endometriosis and ovarian endometrioid/clear cell carcinomas remains to be defined both in terms of entity of association and of underlying molecular mechanisms...
  86. doi request reprint Medical, surgical and alternative treatments for chronic pelvic pain in women: a descriptive review
    Paolo Vercellini
    Clinica Ostetrica e Ginecologica I, University of Milan, Milan, Italy
    Gynecol Endocrinol 25:208-21. 2009
    ..A minority of patients (3-5%) will experience worsening of pain or will develop new symptoms after surgery. Treatment of CPP, generally, requires acceptance of the concept of managing rather than curing symptoms...
  87. doi request reprint Endometrial stromal cells from women with endometriosis reveal peculiar migratory behavior in response to ovarian steroids
    Davide Gentilini
    Molecular Biology Laboratory, Istituto Auxologico Italiano, Milan, Italy
    Fertil Steril 93:706-15. 2010
    ..To evaluate differences in endometrial stromal cell (ESC) migration between patients with and without endometriosis...
  88. ncbi request reprint GnRH antagonists and mild ovarian stimulation for intrauterine insemination: a randomized study comparing different gonadotrophin dosages
    G Ragni
    Infertility Unit, Department of Obstetrics and Gynaecology, University of Milan, Milan, Italy
    Hum Reprod 19:54-8. 2004
    ..In this study, we have compared two different protocols employing GnRH antagonists in order to determine the lower effective dose of gonadotrophins to use...
  89. ncbi request reprint Laparoscopic excision of ovarian cysts does not result in antiovarian humoral autoimmunity
    Ilda Chiodo
    Department of Obstetrics, Gynecology and Neonatology, Fondazione Policlinico Mangiagalli Regina Elena, Milan, Italy
    Fertil Steril 84:1772-4. 2005
    ....
  90. ncbi request reprint Use of serum-soluble intercellular adhesion molecule-1 as a new marker of endometriosis
    Edgardo Somigliana
    II Department of Obstetrics and Gynecology, University of Milan, Istituto Auxologico Italiano, Milan, Italy
    Fertil Steril 77:1028-31. 2002
    ..To investigate the hypothesis that soluble intercellular adhesions molecule-1 (sICAM-1) may be used as a new serum marker of endometriosis...
  91. doi request reprint Decidualized ovarian endometriosis in pregnancy: a challenging diagnostic entity
    Maurizio Barbieri
    Department of Obstetrics, Gynecology and Neonatology, Fondazione Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Via Commenda 12, 20122 Milan, Italy
    Hum Reprod 24:1818-24. 2009
    ..In this study, we report on our experience and perform a review of the literature on this issue...
  92. doi request reprint 'Blood On The Tracks' from corpora lutea to endometriomas
    P Vercellini
    Universita degli Studi di Milano, Milan, Italy
    BJOG 116:366-71. 2009
    ..To detect a direct transition from a haemorrhagic corpus luteum to an endometriotic cyst by serial transvaginal ultrasonographic scans...
  93. ncbi request reprint Progestogens for endometriosis: forward to the past
    Paolo Vercellini
    Clinica Ostetrica e Ginecologica I, Istituto Luigi Mangiagalli, Universita di Milano, Milano, Italy
    Hum Reprod Update 9:387-96. 2003
    ..However, their contraceptive effectiveness limits their use to women who do not wish to have children in the short term...
  94. ncbi request reprint Overweight and obese anovulatory patients with polycystic ovaries: parallel improvements in anthropometric indices, ovarian physiology and fertility rate induced by diet
    Pier Giorgio Crosignani
    Infertility Unit of the First Department Obstetrics and Gynecology, University of Milan, Via della Commenda 12, 20122 Milan, Italy
    Hum Reprod 18:1928-32. 2003
    ..This prospective study evaluated the effect of weight reduction on anthropometric indices and ovarian morphology in anovulatory overweight patients with polycystic ovary syndrome (PCOS)...
  95. ncbi request reprint Health-related quality of life and need for IVF in 1000 Italian infertile couples
    Guido Ragni
    Infertility Unit, Department of Obstetrics and Gynecology, University of Milan, Italy
    Hum Reprod 20:1286-91. 2005
    ..A specific and still poorly investigated issue in the field of infertility is represented by the impact that the need for IVF techniques may have on health-related quality of life (HRQoL)...
  96. ncbi request reprint The 2004 Italian legislation regulating assisted reproduction technology: a multicentre survey on the results of IVF cycles
    G Ragni
    Infertility Unit, Policlinico L Mangiagalli Hospital, Milano, Reproductive Medicine Unit, ANDROS Day Surgery, Palermo Palermo I, Italy
    Hum Reprod 20:2224-8. 2005
    ..Oocyte cryopreservation is allowed while embryo cryostorage is banned. The aim of this study was to evaluate the clinical impact of these limitations...
  97. ncbi request reprint Analysis of the codon 72 polymorphism of the TP53 gene in patients with endometriosis
    D Lattuada
    II Department of Obstetrics and Gynecology, University of Milano, Milano, Italy
    Mol Hum Reprod 10:651-4. 2004
    ..However, a possible susceptibility role of this polymorphism in endometriosis development towards very severe forms cannot be ruled out...
  98. ncbi request reprint Follicular vascularity is not predictive of pregnancy outcome in mild controlled ovarian stimulation and IUI cycles
    G Ragni
    Infertility Unit, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Hum Reprod 22:210-4. 2007
    ....
  99. ncbi request reprint Prevalence of anal incontinence in women with symptoms of urinary incontinence and genital prolapse
    Michele Meschia
    Urogynecology Unit, Department of Obstetrics and Gynecology, University of Milan, Milan, Italy
    Obstet Gynecol 100:719-23. 2002
    ..To investigate risk factors and prevalence of anal incontinence among women with pelvic floor dysfunctions...
  100. ncbi request reprint Risk factors for spontaneous preterm birth: a Northern Italian multicenter case-control study
    Laura Carlini
    2nd Department of Obstetrics and Gynecology, Clinica L Mangiagalli, University of Milan, Italy
    Gynecol Obstet Invest 53:174-80. 2002
    ..6, CI 1.1-2.5). This study confirms that infections play a role in the etiology of preterm birth and that reproductive history is still the most important factor in identifying women at increased risk...
  101. ncbi request reprint In vitro development of human oocytes after parthenogenetic activation or intracytoplasmic sperm injection
    Alessio Paffoni
    Department of Obstetrics, Gynecology, and Neonatology, Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    Fertil Steril 87:77-82. 2007
    ..To compare directly in vitro developmental competence between parthenogenetically activated and intracytoplasmic sperm injection (ICSI)-fertilized oocytes...