A Simeone

Summary

Country: Italy

Publications

  1. ncbi request reprint Positioning the isthmic organizer where Otx2 and Gbx2meet
    A Simeone
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, 80125 Naples, Italy
    Trends Genet 16:237-40. 2000
  2. ncbi request reprint Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Development 125:1691-702. 1998
  3. ncbi request reprint The TINS Lecture. Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Trends Neurosci 22:116-22. 1999
  4. ncbi request reprint Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, Italy
    Development 125:5091-104. 1998
  5. pmc A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo
    A Simeone
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    EMBO J 12:2735-47. 1993
  6. ncbi request reprint Genetic control of brain morphogenesis through Otx gene dosage requirement
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Development 124:3639-50. 1997
  7. ncbi request reprint The role of Otx and Otp genes in brain development
    D Acampora
    International Institute of Genetics and Biophysics, Naples, Italy
    Int J Dev Biol 44:669-77. 2000
  8. ncbi request reprint Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, Italy
    Development 126:1417-26. 1999
  9. ncbi request reprint Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5
    D Acampora
    International Institute of Genetic and Biophysics, CNR, Via Marconi 10, Italy
    Development 126:3795-809. 1999
  10. pmc Isolation and mapping of EVX1, a human homeobox gene homologous to even-skipped, localized at the 5' end of HOX1 locus on chromosome 7
    A Faiella
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Nucleic Acids Res 19:6541-5. 1991

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Positioning the isthmic organizer where Otx2 and Gbx2meet
    A Simeone
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, 80125 Naples, Italy
    Trends Genet 16:237-40. 2000
    ..Recent work has shown that two transcription factors, Otx2 and Gbx2, are instrumental in positioning the isthmic organizer at the midbrain-hindbrain boundary...
  2. ncbi request reprint Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Development 125:1691-702. 1998
    ....
  3. ncbi request reprint The TINS Lecture. Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Trends Neurosci 22:116-22. 1999
    ..In evolutionary terms, some of these findings lead us to hypothesize a fascinating and crucial role for Otx genes that contributes to the genetic program required for the specification of the development of the vertebrate head...
  4. ncbi request reprint Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, Italy
    Development 125:5091-104. 1998
    ..Moreover, our data lead us to hypothesize that the differential post-transcriptional control existing between VE and epiblast cells may potentially contribute to fundamental regulatory mechanisms required for head specification...
  5. pmc A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo
    A Simeone
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    EMBO J 12:2735-47. 1993
    ..Its gene product contains a homeodomain of the bicoid class and is able to recognize and transactivate a bicoid target sequence...
  6. ncbi request reprint Genetic control of brain morphogenesis through Otx gene dosage requirement
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Development 124:3639-50. 1997
    ....
  7. ncbi request reprint The role of Otx and Otp genes in brain development
    D Acampora
    International Institute of Genetics and Biophysics, Naples, Italy
    Int J Dev Biol 44:669-77. 2000
    ....
  8. ncbi request reprint Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, Italy
    Development 126:1417-26. 1999
    ....
  9. ncbi request reprint Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5
    D Acampora
    International Institute of Genetic and Biophysics, CNR, Via Marconi 10, Italy
    Development 126:3795-809. 1999
    ..The defects observed in Dlx5-/- mutant animals suggest multiple and independent roles of this gene in the patterning of the branchial arches, in the morphogenesis of the vestibular organ and in osteoblast differentiation...
  10. pmc Isolation and mapping of EVX1, a human homeobox gene homologous to even-skipped, localized at the 5' end of HOX1 locus on chromosome 7
    A Faiella
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Nucleic Acids Res 19:6541-5. 1991
    ..Both EVX genes are transcribed in an opposite orientation as compared to that of adjacent HOX genes. Human HOX1 and HOX4 complex loci appear to be both closely linked to a homeobox gene of the EVX family...
  11. ncbi request reprint Otx genes and the genetic control of brain morphogenesis
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Via G Marconi, 12, Naples, 80125, Italy
    Mol Cell Neurosci 13:1-8. 1999
    ..Finally, experiments have shown functional equivalence between Drosophila otd and vertebrate Otx genes, suggesting a surprising conservation of function required in brain development throughout evolution...
  12. pmc Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene
    D Acampora
    International Institute of Genetics and Biophysics, Consiglio Nationale delle Ricerche CNR, 80125 Naples, Italy
    Genes Dev 13:2787-800. 1999
    ....
  13. ncbi request reprint Otx genes in corticogenesis and brain development
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Cereb Cortex 9:533-42. 1999
    ..This review deals with the major aspects related to the involvement of Otx1 and Otx2 in the development of the mammalian brain and, in particular, of the cerebral cortex...
  14. ncbi request reprint Retinoic acid induces stage-specific repatterning of the rostral central nervous system
    V Avantaggiato
    International Institute of Genetics and Biophysics, C N R, Naples, Italy
    Dev Biol 175:347-57. 1996
    ....
  15. ncbi request reprint Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and Drosophila
    A Simeone
    International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
    Neuron 13:83-101. 1994
    ....
  16. ncbi request reprint The role of Otx2 in organizing the anterior patterning in mouse
    A Simeone
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Int J Dev Biol 45:337-45. 2001
    ..In evolutionary terms, some of these findings lead us to hypothesize a fascinating and crucial contribution of the Otx genes to the genetic program underlying the establishment of the mammalian brain...
  17. ncbi request reprint Retinoic acid induces stage-specific antero-posterior transformation of rostral central nervous system
    A Simeone
    International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
    Mech Dev 51:83-98. 1995
    ..We suggest that retinoids may contribute to early definition of head from trunk structures by selecting different sets of regulatory genes...
  18. ncbi request reprint Otx genes in brain morphogenesis
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Via G. Marconi 12, 80125 Naples, Italy
    Prog Neurobiol 64:69-95. 2001
    ....
  19. ncbi request reprint Genetic and molecular roles of Otx homeodomain proteins in head development
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, 80125, Naples, Italy
    Gene 246:23-35. 2000
    ..Finally, vertebrate Otx genes share functional equivalence with the Drosophila homologue otd, indicating that the genetic mechanisms underlying pattern formation in insect and mammalian brain development are evolutionarily conserved...
  20. ncbi request reprint Epilepsy and brain abnormalities in mice lacking the Otx1 gene
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Nat Genet 14:218-22. 1996
    ..Our findings indicate that the Otx1 gene product is required for proper brain functions...
  21. ncbi request reprint Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Development 125:1229-39. 1998
    ....
  22. pmc Otx1 and Otx2 in the development and evolution of the mammalian brain
    A Simeone
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, 80125 Naples, Italy
    EMBO J 17:6790-8. 1998
    ..This review deals with the major aspects related to the roles played by Otx1 and Otx2 in the development and evolution of the mammalian brain...
  23. ncbi request reprint Embryonic expression pattern of the murine figf gene, a growth factor belonging to platelet-derived growth factor/vascular endothelial growth factor family
    V Avantaggiato
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, 80125, Naples, Italy
    Mech Dev 73:221-4. 1998
    ....
  24. ncbi request reprint The murine cripto gene: expression during mesoderm induction and early heart morphogenesis
    R Dono
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Development 118:1157-68. 1993
    ..This expression pattern suggests a role for cripto gene in the determination of the epiblastic cells that subsequently give rise to the mesoderm...
  25. pmc Cloning and characterization of two members of the vertebrate Dlx gene family
    A Simeone
    International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
    Proc Natl Acad Sci U S A 91:2250-4. 1994
    ..The expression pattern of these genes, together with their chromosome localization, may provide useful cues for the study of congenital disorders in which there is a combination of craniofacial and limb defects...
  26. ncbi request reprint Expression of the receptor tyrosine kinase substrate genes eps8 and eps15 during mouse development
    V Avantaggiato
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Oncogene 11:1191-8. 1995
    ....
  27. ncbi request reprint Developmental analysis of murine Promyelocyte Leukemia Zinc Finger (PLZF) gene expression: implications for the neuromeric model of the forebrain organization
    V Avantaggiato
    International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
    J Neurosci 15:4927-42. 1995
    ....
  28. ncbi request reprint EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2
    M D'ESPOSITO
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Genomics 10:43-50. 1991
    ..We have identified for the first time a homeogene of a different class at a HOX locus. These findings are relevant to the understanding of the evolution of HOX gene clusters and their regulation...