Research Topics
Genomes and Genes
| A SimeoneSummaryCountry: Italy Publications
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Detail Information
Publications
Positioning the isthmic organizer where Otx2 and Gbx2meetA Simeone
International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, 80125 Naples, Italy
Trends Genet 16:237-40. 2000..Recent work has shown that two transcription factors, Otx2 and Gbx2, are instrumental in positioning the isthmic organizer at the midbrain-hindbrain boundary...- Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain developmentD Acampora
International Institute of Genetics and Biophysics, CNR, Naples, Italy
Development 125:1691-702. 1998.... - The TINS Lecture. Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesisD Acampora
International Institute of Genetics and Biophysics, CNR, Naples, Italy
Trends Neurosci 22:116-22. 1999..In evolutionary terms, some of these findings lead us to hypothesize a fascinating and crucial role for Otx genes that contributes to the genetic program required for the specification of the development of the vertebrate head... - Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulationD Acampora
International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, Italy
Development 125:5091-104. 1998..Moreover, our data lead us to hypothesize that the differential post-transcriptional control existing between VE and epiblast cells may potentially contribute to fundamental regulatory mechanisms required for head specification... 
A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryoA Simeone
International Institute of Genetics and Biophysics, CNR, Naples, Italy
EMBO J 12:2735-47. 1993..Its gene product contains a homeodomain of the bicoid class and is able to recognize and transactivate a bicoid target sequence...- Genetic control of brain morphogenesis through Otx gene dosage requirementD Acampora
International Institute of Genetics and Biophysics, CNR, Naples, Italy
Development 124:3639-50. 1997.... - The role of Otx and Otp genes in brain developmentD Acampora
International Institute of Genetics and Biophysics, Naples, Italy
Int J Dev Biol 44:669-77. 2000.... - Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypesD Acampora
International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, Italy
Development 126:1417-26. 1999.... - Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5D Acampora
International Institute of Genetic and Biophysics, CNR, Via Marconi 10, Italy
Development 126:3795-809. 1999..The defects observed in Dlx5-/- mutant animals suggest multiple and independent roles of this gene in the patterning of the branchial arches, in the morphogenesis of the vestibular organ and in osteoblast differentiation... - Isolation and mapping of EVX1, a human homeobox gene homologous to even-skipped, localized at the 5' end of HOX1 locus on chromosome 7A Faiella
International Institute of Genetics and Biophysics, CNR, Naples, Italy
Nucleic Acids Res 19:6541-5. 1991..Both EVX genes are transcribed in an opposite orientation as compared to that of adjacent HOX genes. Human HOX1 and HOX4 complex loci appear to be both closely linked to a homeobox gene of the EVX family... - Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia geneD Acampora
International Institute of Genetics and Biophysics, Consiglio Nationale delle Ricerche CNR, 80125 Naples, Italy
Genes Dev 13:2787-800. 1999.... - Otx genes and the genetic control of brain morphogenesisD Acampora
International Institute of Genetics and Biophysics, CNR, Via G Marconi, 12, Naples, 80125, Italy
Mol Cell Neurosci 13:1-8. 1999..Finally, experiments have shown functional equivalence between Drosophila otd and vertebrate Otx genes, suggesting a surprising conservation of function required in brain development throughout evolution... - Otx genes in corticogenesis and brain developmentD Acampora
International Institute of Genetics and Biophysics, CNR, Naples, Italy
Cereb Cortex 9:533-42. 1999..This review deals with the major aspects related to the involvement of Otx1 and Otx2 in the development of the mammalian brain and, in particular, of the cerebral cortex... - Retinoic acid induces stage-specific repatterning of the rostral central nervous systemV Avantaggiato
International Institute of Genetics and Biophysics, C N R, Naples, Italy
Dev Biol 175:347-57. 1996.... - Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and DrosophilaA Simeone
International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
Neuron 13:83-101. 1994.... - The role of Otx2 in organizing the anterior patterning in mouseA Simeone
International Institute of Genetics and Biophysics, CNR, Naples, Italy
Int J Dev Biol 45:337-45. 2001..In evolutionary terms, some of these findings lead us to hypothesize a fascinating and crucial contribution of the Otx genes to the genetic program underlying the establishment of the mammalian brain... - Retinoic acid induces stage-specific antero-posterior transformation of rostral central nervous systemA Simeone
International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
Mech Dev 51:83-98. 1995..We suggest that retinoids may contribute to early definition of head from trunk structures by selecting different sets of regulatory genes... - Otx genes in brain morphogenesisD Acampora
International Institute of Genetics and Biophysics, CNR, Via G. Marconi 12, 80125 Naples, Italy
Prog Neurobiol 64:69-95. 2001.... - Genetic and molecular roles of Otx homeodomain proteins in head developmentD Acampora
International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, 80125, Naples, Italy
Gene 246:23-35. 2000..Finally, vertebrate Otx genes share functional equivalence with the Drosophila homologue otd, indicating that the genetic mechanisms underlying pattern formation in insect and mammalian brain development are evolutionarily conserved... - Epilepsy and brain abnormalities in mice lacking the Otx1 geneD Acampora
International Institute of Genetics and Biophysics, CNR, Naples, Italy
Nat Genet 14:218-22. 1996..Our findings indicate that the Otx1 gene product is required for proper brain functions... - Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LHD Acampora
International Institute of Genetics and Biophysics, CNR, Naples, Italy
Development 125:1229-39. 1998.... - Otx1 and Otx2 in the development and evolution of the mammalian brainA Simeone
International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, 80125 Naples, Italy
EMBO J 17:6790-8. 1998..This review deals with the major aspects related to the roles played by Otx1 and Otx2 in the development and evolution of the mammalian brain... - Embryonic expression pattern of the murine figf gene, a growth factor belonging to platelet-derived growth factor/vascular endothelial growth factor familyV Avantaggiato
International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, 80125, Naples, Italy
Mech Dev 73:221-4. 1998.... - The murine cripto gene: expression during mesoderm induction and early heart morphogenesisR Dono
International Institute of Genetics and Biophysics, CNR, Naples, Italy
Development 118:1157-68. 1993..This expression pattern suggests a role for cripto gene in the determination of the epiblastic cells that subsequently give rise to the mesoderm... - Cloning and characterization of two members of the vertebrate Dlx gene familyA Simeone
International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
Proc Natl Acad Sci U S A 91:2250-4. 1994..The expression pattern of these genes, together with their chromosome localization, may provide useful cues for the study of congenital disorders in which there is a combination of craniofacial and limb defects... - Expression of the receptor tyrosine kinase substrate genes eps8 and eps15 during mouse developmentV Avantaggiato
International Institute of Genetics and Biophysics, CNR, Naples, Italy
Oncogene 11:1191-8. 1995.... - Developmental analysis of murine Promyelocyte Leukemia Zinc Finger (PLZF) gene expression: implications for the neuromeric model of the forebrain organizationV Avantaggiato
International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
J Neurosci 15:4927-42. 1995.... - EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2M D'ESPOSITO
International Institute of Genetics and Biophysics, CNR, Naples, Italy
Genomics 10:43-50. 1991..We have identified for the first time a homeogene of a different class at a HOX locus. These findings are relevant to the understanding of the evolution of HOX gene clusters and their regulation...