Renza Roncarati

Summary

Affiliation: Siena Biotech S.p.A
Country: Italy

Publications

  1. doi request reprint Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors
    Tamara Seredenina
    Siena Biotech S p A, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy
    Biosci Rep 28:299-306. 2008
  2. doi request reprint Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders
    Renza Roncarati
    Siena Biotech SpA, Siena, Italy
    J Pharmacol Exp Ther 329:459-68. 2009
  3. doi request reprint Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line
    Renza Roncarati
    Discovery Research, Siena Biotech S p A, Siena, Italy
    Assay Drug Dev Technol 6:181-93. 2008
  4. ncbi request reprint Assembly and trafficking of human small conductance Ca2+-activated K+ channel SK3 are governed by different molecular domains
    Renza Roncarati
    Department of Medicine and Public Health, Section of Pharmacology, University of Verona, 37134 Verona, Italy
    Mol Cell Neurosci 28:314-25. 2005
  5. doi request reprint VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin
    Lara Rossini
    Siena Biotech SpA, Strada del Petriccio e Belriguardo n 35, 53100 Siena, Italy
    FASEB J 25:1983-2000. 2011
  6. ncbi request reprint SK3 trafficking in hippocampal cells: the role of different molecular domains
    Ilaria Decimo
    Department of Medicine and Public Health, University of Verona, P le L Scuro 10, 37100 Verona, Italy
    Biosci Rep 26:399-412. 2006
  7. doi request reprint Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-
    Chiara Ghiron
    Siena Biotech SpA, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy
    J Med Chem 53:4379-89. 2010
  8. doi request reprint Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity
    Giuseppe Pollio
    Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100 Siena, Italy
    Neurobiol Dis 31:145-58. 2008
  9. doi request reprint Screening technologies for ion channel drug discovery
    Georg C Terstappen
    Siena Biotech S p A, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy
    Future Med Chem 2:715-30. 2010
  10. ncbi request reprint Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1
    Carla Scali
    Siena Biotech S p A, 53100 Siena, Italy
    Neurobiol Dis 24:254-65. 2006

Collaborators

Detail Information

Publications13

  1. doi request reprint Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors
    Tamara Seredenina
    Siena Biotech S p A, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy
    Biosci Rep 28:299-306. 2008
    ..The RIC-3e protein is functionally active and enables surface expression of mature alpha7-nAChRs in cell lines not otherwise permissive for the expression of this receptor...
  2. doi request reprint Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders
    Renza Roncarati
    Siena Biotech SpA, Siena, Italy
    J Pharmacol Exp Ther 329:459-68. 2009
    ....
  3. doi request reprint Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line
    Renza Roncarati
    Discovery Research, Siena Biotech S p A, Siena, Italy
    Assay Drug Dev Technol 6:181-93. 2008
    ..This recombinant cell system is useful for characterization of alpha7 nAChRs and to study the mechanism of action of chemical modulators, in particular the detection of PAMs capable of slowing receptor desensitization kinetics...
  4. ncbi request reprint Assembly and trafficking of human small conductance Ca2+-activated K+ channel SK3 are governed by different molecular domains
    Renza Roncarati
    Department of Medicine and Public Health, Section of Pharmacology, University of Verona, 37134 Verona, Italy
    Mol Cell Neurosci 28:314-25. 2005
    ..Thus, these two C-terminal regions of SK3 seem to contribute to assembly and trafficking of channels whereas the N-terminus is necessary for trafficking but not sufficient for oligomerization...
  5. doi request reprint VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin
    Lara Rossini
    Siena Biotech SpA, Strada del Petriccio e Belriguardo n 35, 53100 Siena, Italy
    FASEB J 25:1983-2000. 2011
    ..In summary, VSTM2L is the first example of a secreted antagonist of HN and may play a role in the modulation of HN biological functions...
  6. ncbi request reprint SK3 trafficking in hippocampal cells: the role of different molecular domains
    Ilaria Decimo
    Department of Medicine and Public Health, University of Verona, P le L Scuro 10, 37100 Verona, Italy
    Biosci Rep 26:399-412. 2006
    ..In conclusion, the current work provides evidence for a fundamental role of the N-terminal domain and the calmodulin binding domain in SK3 trafficking in neurons...
  7. doi request reprint Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-
    Chiara Ghiron
    Siena Biotech SpA, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy
    J Med Chem 53:4379-89. 2010
    ..Structural modifications leading to the improved selectivity profile and the biological evaluation of this series of compounds are discussed...
  8. doi request reprint Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity
    Giuseppe Pollio
    Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100 Siena, Italy
    Neurobiol Dis 31:145-58. 2008
    ....
  9. doi request reprint Screening technologies for ion channel drug discovery
    Georg C Terstappen
    Siena Biotech S p A, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy
    Future Med Chem 2:715-30. 2010
    ..In this review we provide an overview of the current repertoire of screening technologies that has evolved to drive ion channel-targeted drug discovery towards new medicines of the future...
  10. ncbi request reprint Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1
    Carla Scali
    Siena Biotech S p A, 53100 Siena, Italy
    Neurobiol Dis 24:254-65. 2006
    ..The demonstration that DKK1 inhibits Wnt signaling in neurons and causes neuronal death supports the hypothesis that inhibition of the canonical Wnt pathway contributes to the pathophysiology of neurodegenerative disorders...
  11. ncbi request reprint In vitro screening strategies for nicotinic receptor ligands
    John Dunlop
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Biochem Pharmacol 74:1172-81. 2007
    ....
  12. ncbi request reprint Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties
    Andrea Caricasole
    GlaxoSmithKline Systems Research and Department of Biology, Via Fleming 4, 37135 Verona, Italy
    J Biol Chem 277:4790-6. 2002
    ..Therefore, the human diacylglycerol kinase beta gene can generate several enzyme isoforms, which can display different expression levels and subcellular localization but similar enzymatic activities in vitro...
  13. ncbi request reprint Pharmacological and molecular characterisation of SK3 channels in the TE671 human medulloblastoma cell line
    Corrado Carignani
    GlaxoSmithKline Medicines Research Centre, Verona, Italy
    Brain Res 939:11-8. 2002
    ..3 nM. Furthermore, the current was significantly increased (132.6+/-5.2%, n=7) by 500 microM 1-ethyl-2-benzimidazolinone (EBIO). Collectively, these data demonstrate the presence of an endogenous SK3 channel in human TE671 cells...