Andrea Caricasole

Summary

Affiliation: Siena Biotech S.p.A
Country: Italy

Publications

  1. pmc Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene
    Margherita Gaviraghi
    Department of Pathology, Section of Pathological Anatomy, University of Verona, Verona, Italy
    BMC Mol Biol 9:56. 2008
  2. ncbi Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins
    Andrea Caricasole
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    J Biol Chem 278:37024-31. 2003
  3. ncbi Differential activation of the calcium/protein kinase C and the canonical beta-catenin pathway by Wnt1 and Wnt7a produces opposite effects on cell proliferation in PC12 cells
    Paola Spinsanti
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Neurochem 104:1588-98. 2008
  4. ncbi Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells
    Alessandra Caruso
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Neurochem 98:364-71. 2006
  5. ncbi The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease?
    Andrea Caricasole
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Italy
    Trends Pharmacol Sci 24:233-8. 2003
  6. doi VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin
    Lara Rossini
    Siena Biotech SpA, Strada del Petriccio e Belriguardo n 35, 53100 Siena, Italy
    FASEB J 25:1983-2000. 2011
  7. ncbi Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death
    Irene Cappuccio
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, 00185 Rome, Italy
    J Neurosci 25:2647-57. 2005
  8. ncbi Aryl azoles with neuroprotective activity--parallel synthesis and attempts at target identification
    Giuseppe Cocconcelli
    Siena Biotech S p A, Via Fiorentina 1, 53100 Siena, Italy
    Bioorg Med Chem 16:2043-52. 2008
  9. ncbi A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity
    Andrea Caricasole
    Institute of Human Physiology and Pharmacology Vittorio Erspamer, Department of Human Physiology and Pharmacology, University of Rome La Sapienza, 00185, Rome, Italy
    FASEB J 16:1331-3. 2002
  10. ncbi Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain
    Andrea Caricasole
    Siena Biotech, 53100 Siena, Italy
    J Neurosci 24:6021-7. 2004

Collaborators

Detail Information

Publications11

  1. pmc Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene
    Margherita Gaviraghi
    Department of Pathology, Section of Pathological Anatomy, University of Verona, Verona, Italy
    BMC Mol Biol 9:56. 2008
    ....
  2. ncbi Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins
    Andrea Caricasole
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    J Biol Chem 278:37024-31. 2003
    ..Our functional analysis indicates that WNT7A can specifically act via a Frizzled-5.LRP6 receptor complex in PC12 cells and that this activity can be antagonized by Dickkopf-1 and Dickkopf-3...
  3. ncbi Differential activation of the calcium/protein kinase C and the canonical beta-catenin pathway by Wnt1 and Wnt7a produces opposite effects on cell proliferation in PC12 cells
    Paola Spinsanti
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Neurochem 104:1588-98. 2008
    ....
  4. ncbi Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells
    Alessandra Caruso
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Neurochem 98:364-71. 2006
    ..We conclude that ApoE4 behaves as an inhibitor of the canonical Wnt pathway in a context-independent manner...
  5. ncbi The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease?
    Andrea Caricasole
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Italy
    Trends Pharmacol Sci 24:233-8. 2003
    ..Furthermore, late downregulation of Wnt signaling by betaAP might lead to NFT formation. We propose that drugs that both inhibit the cell cycle and rescue Wnt activity could provide novel AD therapeutics...
  6. doi VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin
    Lara Rossini
    Siena Biotech SpA, Strada del Petriccio e Belriguardo n 35, 53100 Siena, Italy
    FASEB J 25:1983-2000. 2011
    ..In summary, VSTM2L is the first example of a secreted antagonist of HN and may play a role in the modulation of HN biological functions...
  7. ncbi Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death
    Irene Cappuccio
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, 00185 Rome, Italy
    J Neurosci 25:2647-57. 2005
    ..We conclude that induction of Dkk-1 with the ensuing inhibition of the canonical Wnt signaling pathway is required for the development of ischemic and excitotoxic neuronal death...
  8. ncbi Aryl azoles with neuroprotective activity--parallel synthesis and attempts at target identification
    Giuseppe Cocconcelli
    Siena Biotech S p A, Via Fiorentina 1, 53100 Siena, Italy
    Bioorg Med Chem 16:2043-52. 2008
    ..The compounds tested showed an activity between 40% and 70%. The identification of neuroprotective small molecules and the identification of NaV channels as the potential site of action were the most important goals of this work...
  9. ncbi A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity
    Andrea Caricasole
    Institute of Human Physiology and Pharmacology Vittorio Erspamer, Department of Human Physiology and Pharmacology, University of Rome La Sapienza, 00185, Rome, Italy
    FASEB J 16:1331-3. 2002
    ..The identification of Rattin may be instrumental for the development of novel pharmacological strategies aimed at enhancing the production of endogenous Humanin-like peptides...
  10. ncbi Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain
    Andrea Caricasole
    Siena Biotech, 53100 Siena, Italy
    J Neurosci 24:6021-7. 2004
    ..We conclude that induction of DKK1 contributes to the pathological cascade triggered by beta-amyloid and is critically involved in the process of tau phosphorylation...
  11. ncbi Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1
    Carla Scali
    Siena Biotech S p A, 53100 Siena, Italy
    Neurobiol Dis 24:254-65. 2006
    ..The demonstration that DKK1 inhibits Wnt signaling in neurons and causes neuronal death supports the hypothesis that inhibition of the canonical Wnt pathway contributes to the pathophysiology of neurodegenerative disorders...