A Albini

Summary

Affiliation: Sesto San Giovanni
Country: Italy

Publications

  1. ncbi request reprint The "chemoinvasion assay": a tool to study tumor and endothelial cell invasion of basement membranes
    Adriana Albini
    National Cancer Research Institute, 16132 Genova, Italy
    Int J Dev Biol 48:563-71. 2004
  2. ncbi request reprint A new tumor suppressor gene: invasion, metastasis, and angiogenesis as potential key targets
    Adriana Albini
    J Natl Cancer Inst 98:800-1. 2006
  3. doi request reprint Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells
    Roberto Bianco
    Cattedra di Oncologia Medica, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Universita di Napoli Federico II, Via S Pansini 5, Naples, Italy
    Clin Cancer Res 14:5069-80. 2008
  4. pmc Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth
    A R Cantelmo
    Oncology Research, Science and Technology Pole, Casa di Cura MultiMedica IRCCS, Milan, Italy
    Oncogene 29:5286-98. 2010
  5. pmc The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker
    Rosaria Cammarota
    Oncology Research Laboratory, Science and Technology Park, IRCCS Multimedica, via Fantoli 16 15, Milan, 20138, Italy
    J Transl Med 8:112. 2010
  6. pmc Prediction of breast cancer metastasis by genomic profiling: where do we stand?
    Ulrich Pfeffer
    Functional Genomics, National Cancer Research Institute, Genoa, Italy
    Clin Exp Metastasis 26:547-58. 2009
  7. ncbi request reprint The tumour microenvironment as a target for chemoprevention
    Adriana Albini
    IRCCS Multimedica Science and Technology Park, Viale Fantoli 15 16, Milan, 20138, Italy
    Nat Rev Cancer 7:139-47. 2007
  8. pmc Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention
    Adriana Albini
    Oncology Research Division, MultiMedica Castellanza VA, Milan, Italy
    J Natl Cancer Inst 102:14-25. 2010
  9. doi request reprint Cardio-oncology in targeting the HER receptor family: the puzzle of different cardiotoxicities of HER2 inhibitors
    Adriana Albini
    Oncology Research Division, Polo Scientifico e Tecnologico IRCCS MultiMedica, Via Fantoli 16 15 20138, Milan, Italy
    Future Cardiol 7:693-704. 2011
  10. doi request reprint Functional genomics of endothelial cells treated with anti-angiogenic or angiopreventive drugs
    Adriana Albini
    MultiMedica Castellanza VA and Oncology Research, IRCCS Multimedica, 20138 Milan, Italy
    Clin Exp Metastasis 27:419-39. 2010

Collaborators

Detail Information

Publications86

  1. ncbi request reprint The "chemoinvasion assay": a tool to study tumor and endothelial cell invasion of basement membranes
    Adriana Albini
    National Cancer Research Institute, 16132 Genova, Italy
    Int J Dev Biol 48:563-71. 2004
    ..We will describe the assay and review some of the major results it enabled to obtain...
  2. ncbi request reprint A new tumor suppressor gene: invasion, metastasis, and angiogenesis as potential key targets
    Adriana Albini
    J Natl Cancer Inst 98:800-1. 2006
  3. doi request reprint Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells
    Roberto Bianco
    Cattedra di Oncologia Medica, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Universita di Napoli Federico II, Via S Pansini 5, Naples, Italy
    Clin Cancer Res 14:5069-80. 2008
    ..Combined inhibition of EGFR and other signaling proteins has become a successful therapeutic approach, stimulating the search for further determinants of resistance as basis for novel therapeutic strategies...
  4. pmc Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth
    A R Cantelmo
    Oncology Research, Science and Technology Pole, Casa di Cura MultiMedica IRCCS, Milan, Italy
    Oncogene 29:5286-98. 2010
    ....
  5. pmc The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker
    Rosaria Cammarota
    Oncology Research Laboratory, Science and Technology Park, IRCCS Multimedica, via Fantoli 16 15, Milan, 20138, Italy
    J Transl Med 8:112. 2010
    ....
  6. pmc Prediction of breast cancer metastasis by genomic profiling: where do we stand?
    Ulrich Pfeffer
    Functional Genomics, National Cancer Research Institute, Genoa, Italy
    Clin Exp Metastasis 26:547-58. 2009
    ..Already today, signatures are, however, useful for clinical decisions in specific cases, in particular if the personal inclination of the patient towards different treatment strategies is taken into account...
  7. ncbi request reprint The tumour microenvironment as a target for chemoprevention
    Adriana Albini
    IRCCS Multimedica Science and Technology Park, Viale Fantoli 15 16, Milan, 20138, Italy
    Nat Rev Cancer 7:139-47. 2007
    ..Finally, we make suggestions for more effective clinical implementation of this knowledge in preventive strategies...
  8. pmc Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention
    Adriana Albini
    Oncology Research Division, MultiMedica Castellanza VA, Milan, Italy
    J Natl Cancer Inst 102:14-25. 2010
    ..We also discuss mechanistic pathways and describe several potential protective agents that could be administered to patients with occult or overt risk for cardiovascular complications...
  9. doi request reprint Cardio-oncology in targeting the HER receptor family: the puzzle of different cardiotoxicities of HER2 inhibitors
    Adriana Albini
    Oncology Research Division, Polo Scientifico e Tecnologico IRCCS MultiMedica, Via Fantoli 16 15 20138, Milan, Italy
    Future Cardiol 7:693-704. 2011
    ....
  10. doi request reprint Functional genomics of endothelial cells treated with anti-angiogenic or angiopreventive drugs
    Adriana Albini
    MultiMedica Castellanza VA and Oncology Research, IRCCS Multimedica, 20138 Milan, Italy
    Clin Exp Metastasis 27:419-39. 2010
    ....
  11. ncbi request reprint Metastasis signatures: genes regulating tumor-microenvironment interactions predict metastatic behavior
    Adriana Albini
    IRCCS Multimedica, Scientific and Technological Pole, via Fantoli 16 15, 20138, Milan, Italy
    Cancer Metastasis Rev 27:75-83. 2008
    ..Here we review these concepts and advance hypotheses on how gene expression of the primary tumor and the microenvironment can favor the spread of the metastasis seeds and how this knowledge can provide tools to secondary prevention...
  12. ncbi request reprint The tumor microenvironment: biology of a complex cellular and tissue society
    A Albini
    MultiMedica Clinical Center, Castellanza, Varese, Italy
    Q J Nucl Med Mol Imaging 54:244-8. 2010
    ..In this complex scenario molecular imaging of the microenvironment is crucial to dissect cellular and stromal dynamic contributions...
  13. doi request reprint The 'chemoinvasion' assay, 25 years and still going strong: the use of reconstituted basement membranes to study cell invasion and angiogenesis
    Adriana Albini
    Polo Scientifico e Tecnologico, Casa di Cura MultiMedica IRCCS, Milan and Castellanza VA, Italy
    Curr Opin Cell Biol 22:677-89. 2010
    ..We review established applications and variants of the matrigel invasion assay, highlight key findings derived from it and discuss future developments, including roles for accessory and cancer stem cells...
  14. ncbi request reprint Cancer stem cells and the tumor microenvironment: soloists or choral singers
    A Albini
    Oncology Research, Science and Technology Park, IRCCS Multimedica, via Fantoli 16 15, Milan, Italy
    Curr Pharm Biotechnol 12:171-81. 2011
    ..Here we propose models of replication and quiescence and the modulation by cells, genes and miRNAs. We also summarize in a table surface makers useful for the identification and isolation of CSCs...
  15. ncbi request reprint Tumor microenvironment, a dangerous society leading to cancer metastasis. From mechanisms to therapy and prevention
    Adriana Albini
    IRCCS Multimedica Milano, Milan, Italy
    Cancer Metastasis Rev 27:3-4. 2008
    ....
  16. ncbi request reprint Molecular pathways for cancer angioprevention
    Adriana Albini
    IRCCS Multimedica, Milan, Italy
    Clin Cancer Res 13:4320-5. 2007
    ..We highlight diverse mechanisms of action, implying that combination angioprevention approaches could further improve efficacy and be transferred to clinical practice...
  17. ncbi request reprint Inhibition of a vascular ocular tumor growth by IL-12 gene transfer
    Adriana Albini
    Istituto di Ricovero e Cura a Carattere Scientifico MultiMedica, Via Fantoli Gaudenzio, 16 15, Milano 20138, Italy
    Clin Exp Metastasis 24:485-93. 2007
    ..Taken together, our data suggest that IL-12 gene transfer can provide anti-angiogenic effects without toxicity and may be particularly suited for therapy of vascularized ocular tumors...
  18. ncbi request reprint The chemoinvasion assay: a method to assess tumor and endothelial cell invasion and its modulation
    Adriana Albini
    Polo Scientifico e Tecnologico, IRCCS Multimedica, Milano, Italy
    Nat Protoc 2:504-11. 2007
    ..This protocol can be completed in 9 h...
  19. ncbi request reprint Antiangiogenic activity of chemopreventive drugs
    U Pfeffer
    Laboratory of Molecular Oncology, National Cancer Research Institute, Genoa, Italy
    Int J Biol Markers 18:70-4. 2003
    ..These drugs appear to target common mechanisms of tumor angiogenesis that may permit identification of critical targets for antiangiogenic therapy and antiangiogenic chemoprevention...
  20. ncbi request reprint Microarray expression profiles of angiogenesis-related genes predict tumor cell response to artemisinins
    L Anfosso
    Experimental Oncology A, National Cancer Research Institute, Genova, Italy
    Pharmacogenomics J 6:269-78. 2006
    ..As many chemopreventive drugs exert antiangiogenic features, ARSs might also be chemopreventive in addition to their cytotoxic effects...
  21. doi request reprint Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent
    Girieca Lorusso
    IRCCS Multimedica, Responsabile Ricerca Oncologica, via Fantoli 16 15, 20138 Milan, Italy
    Eur J Cancer 45:1474-84. 2009
    ....
  22. ncbi request reprint The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent
    Nicola Vannini
    Multimedica IRCCS, Milan, Italy
    Mol Cancer Ther 6:3139-46. 2007
    ....
  23. ncbi request reprint Multiple points of intervention in the prevention of cancer and other mutation-related diseases
    S De Flora
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Mutat Res 480:9-22. 2001
    ....
  24. ncbi request reprint Kaposi's sarcoma cells of different etiologic origins respond to HIV-Tat through the Flk-1/KDR (VEGFR-2): relevance in AIDS-KS pathology
    M Morini
    Molecular Biology Laboratory, Tumor Progression Section, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi 10, Genoa, 16132, Italy
    Biochem Biophys Res Commun 273:267-71. 2000
    ....
  25. pmc Angiostatin anti-angiogenesis requires IL-12: the innate immune system as a key target
    Adriana Albini
    Polo Scientifico e Tecnologico, IRCCS Multimedica, Milan, Italy
    J Transl Med 7:5. 2009
    ..Here we present evidence that IL-12, a principal TH1 cytokine with potent anti-angiogenic activity, is the mediator of angiostatin's activity...
  26. ncbi request reprint Diet-derived phytochemicals: from cancer chemoprevention to cardio-oncological prevention
    N Ferrari
    Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Curr Drug Targets 12:1909-24. 2011
    ....
  27. ncbi request reprint HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons
    R Bonavia
    Pharmacology and Neuroscience, National Cancer Research Institute, c o Advanced Biotechnology Center, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Biochem Biophys Res Commun 288:301-8. 2001
    ....
  28. ncbi request reprint Angiogenesis and cancer prevention: a vision
    Douglas M Noonan
    Dipartimento di Scienze Biologiche e Cliniche, Universita dell Insubria, Varese, Italy
    Recent Results Cancer Res 174:219-24. 2007
    ....
  29. ncbi request reprint Nonrandom chromosome changes in Kaposi sarcoma: cytogenetic and FISH results in a new cell line (KS-IMM) and literature review
    R Casalone
    Laboratorio di Citogenetica e Genetica, Ospedale di Circolo e Università dell Insubria, Viale Borri 57, 21100, Varese, Italy
    Cancer Genet Cytogenet 124:16-9. 2001
    ..If many chromosome changes are present, particularly 8q and 1q trisomy, 3p14-->pter deletion, 1p13, 13p14.3, 7q22, 8p11, 13q11, and 19q13 band rearrangements, KS acquires a neoplastic aggressive state...
  30. ncbi request reprint Growth factors and chemokines: a comparative functional approach between invertebrates and vertebrates
    G Tettamanti
    Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy
    Curr Med Chem 13:2737-50. 2006
    ....
  31. doi request reprint Angioprevention with fenretinide: targeting angiogenesis in prevention and therapeutic strategies
    Ilaria Sogno
    IRCCS Multimedica, Milan, Italy
    Crit Rev Oncol Hematol 75:2-14. 2010
    ....
  32. ncbi request reprint Endothelial cell aging and apoptosis in prevention and disease: E-selectin expression and modulation as a model
    Nicola Vannini
    Department of Clinical and Biological Sciences, Universita degli Studi dell Insubria, School of Medicine, Varese, Italy
    Curr Pharm Des 14:221-5. 2008
    ..These data underscore the effects of a chemoprevention agent in modulating parameters associated with endothelial cell aging...
  33. ncbi request reprint Anti-angiogenic properties of chemopreventive drugs: fenretinide as a prototype
    Ilaria Sogno
    IRCCS Multimedica, Oncology Research, Milan, Italy
    Recent Results Cancer Res 181:71-6. 2009
    ....
  34. ncbi request reprint Novel cell death pathways induced by N-(4-hydroxyphenyl)retinamide: therapeutic implications
    Roberta Vené
    IRCCS Multimedica, Polo Scientifico e Tecnologico, Settore Ricerca Oncologica, Via Fantoli 15 16, Milan, Italy
    Mol Cancer Ther 6:286-98. 2007
    ..The novel finding of a lysosome-mediated cell death pathway activated by 4HPR could have implications at clinical level for the development of combination chemoprevention and therapy of cancer...
  35. ncbi request reprint Inflammation, inflammatory cells and angiogenesis: decisions and indecisions
    Douglas M Noonan
    Department of Clinical and Biological Sciences, Universita degli Studi dell Insubria, Via Ottorino Rossi 9, 21100, Varese, Italy
    Cancer Metastasis Rev 27:31-40. 2008
    ..Thus the immune system itself represents a major pharmaceutical target and links angiogenesis inhibition to immunotherapy...
  36. doi request reprint Interactions of single-wall carbon nanotubes with endothelial cells
    Adriana Albini
    Polo Scientifico e Tecnologico, IRCCS Multimedica, Milano, Italy
    Nanomedicine 6:277-88. 2010
    ..The implications on their biological activity must be taken into account when considering the use of these nanoparticles for therapeutic delivery of drugs...
  37. ncbi request reprint Angioprevention': angiogenesis is a common and key target for cancer chemopreventive agents
    Francesca Tosetti
    Molecular Biology Laboratory, National Cancer Research Institute IST, Genova, Italy
    FASEB J 16:2-14. 2002
    ..We analyze the mechanisms on how and why chemopreventive agents could exert antiangiogenic effects aimed at controlling tumor growth, and their potential use in the clinic...
  38. ncbi request reprint AKT/NF-kappaB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies
    Claudia Ambrosini
    Molecular Oncology, National Institute for Cancer Research, Genova, Italy
    Cancer 110:2007-11. 2007
    ..Leukemias are dependent on Akt/NF-kappaB activation and angiogenesis...
  39. ncbi request reprint Induction of apoptosis by fenretinide in tumor cell lines correlates with DLX2, DLX3 and DLX4 gene expression
    Nicoletta Ferrari
    Istituto Nazionale per la Ricerca sul Cancro IST, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Oncol Rep 10:973-7. 2003
    ..Our data support the notion that DLX2, 3, 4 genes could participate in the control of 4HPR-mediated apoptosis, making them important molecules for the monitoring of therapy efficacy in cancer patients...
  40. ncbi request reprint Proteinase-3 directly activates MMP-2 and degrades gelatin and Matrigel; differential inhibition by (-)epigallocatechin-3-gallate
    Elga Pezzato
    Department of Experimental Biomedical Sciences, Medical School, Padova, Italy
    J Leukoc Biol 74:88-94. 2003
    ..These results add new activities to the list of those exerted by PR-3 and indicate a differential inhibition as a result of EGCG...
  41. pmc Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo
    Laura Rosanò
    Laboratories of Molecular Pathology and Ultrastructure and Immunology, Regina Elena Cancer Institute, and the Molecular Biology and Pathology Institute, Consiglio Nazionale delle Ricerche, Rome, Italy
    Am J Pathol 163:753-62. 2003
    ..Such activities can be blocked by the ET(A/B)R antagonists, which may be effective anti-angiogenic and anti-tumor molecules for the treatment of Kaposi's sarcoma...
  42. ncbi request reprint The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice
    Beatrice Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Surgical Hospital, Ludwig Maximilians University Munich, Germany
    Cell Physiol Biochem 19:137-52. 2007
    ..Dietary chemoprevention of metastases appears therefore feasible...
  43. ncbi request reprint Inhibition of tumor angiogenesis by angiostatin: from recombinant protein to gene therapy
    Raffaella Dell'eva
    Laboratory of Molecular Biology, National Cancer Research Institute, Genoa, Italy
    Endothelium 9:3-10. 2002
    ..In this review we compare the different gene therapy strategies that have been applied to angiostatin, with special regard to their ability to provide sufficient angiostatin at the target site...
  44. ncbi request reprint Allele-specific patterns of the mouse parathyroid hormone-related protein: influences on cell adhesion and migration
    Roberto Benelli
    Molecular Biology Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Oncogene 22:7711-5. 2003
    ..These findings suggest that the cancer modifier effects of the mouse Pthlh gene are mediated by differential cell adhesion and migration effects of PTHrP variants...
  45. ncbi request reprint Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis
    Massimo Dona
    Department of Experimental Biomedical Sciences, Medical School of Padova, Padova, Italy
    J Immunol 170:4335-41. 2003
    ..These results provide molecular and cellular insights into the claimed beneficial properties of green tea and indicate that EGCG is a potent anti-inflammatory compound with therapeutic potential...
  46. ncbi request reprint The angiogenic switch in solid tumors: clinical implications
    Francesca Tosetti
    Laboratory of Molecular Biology, National Cancer Research Institute, Genoa, Italy
    Suppl Tumori 1:S9-11. 2002
  47. doi request reprint Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation
    Stefano Monteghirfo
    Oncologia Molecolare, Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi, 10, 16132 Genova, Italy
    Mol Cancer Ther 7:2692-702. 2008
    ....
  48. ncbi request reprint N-(4-hydroxyphenyl)retinamide inhibits retinoblastoma growth through reactive oxygen species-mediated cell death
    Francesca Tosetti
    Molecular Oncology Laboratory, Genova, Italy
    Mol Pharmacol 63:565-73. 2003
    ..These findings could have an important translational value for chemoprevention or early intervention in the treatment of retinoblastoma...
  49. ncbi request reprint Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets
    Adriana Albini
    Molecular Oncology Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    FASEB J 20:527-9. 2006
    ..Our results suggest that XN can be added to the expanding list of antiangiogenic chemopreventive drugs whose potential in cancer prevention and therapy should be evaluated...
  50. ncbi request reprint Human chorionic gonadotropin inhibits Kaposi's sarcoma associated angiogenesis, matrix metalloprotease activity, and tumor growth
    Ulrich Pfeffer
    Laboratory of Molecular Biology, National Cancer Research Institute Genova, c o Advanced Biotechnology Center Genova, Large Rosanna Benzi 10, Genoa 16132, Italy
    Endocrinology 143:3114-21. 2002
    ....
  51. ncbi request reprint Role of the alpha3beta1 and alpha6beta4 integrins in tumor invasion
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, University of Bari Medical School, Italy
    Clin Exp Metastasis 19:217-23. 2002
    ..In this Review, we will focus on the role of these two receptors and the mechanisms by which they influence the invasion process...
  52. ncbi request reprint Angiostatin inhibits extracellular HIV-Tat-induced inflammatory angiogenesis
    Roberto Benelli
    Molecular Biology Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Int J Oncol 22:87-91. 2003
    ..As these cell types are also the targets of extracellularly released Tat, angiostatin could be used to contrast Tat-associated vasculopathies...
  53. ncbi request reprint Oxytocin is a growth factor for Kaposi's sarcoma cells: evidence of endocrine-immunological cross-talk
    Paola Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Cancer Res 62:2406-13. 2002
    ....
  54. ncbi request reprint The urokinase-type plasminogen activator, its receptor and u-PA inhibitor type-1 affect in vitro growth and invasion of Kaposi's sarcoma and capillary endothelial cells: role of HIV-Tat protein
    Francesca Margheri
    Department of Experimental Pathology and Oncology, University of Florence, Italy
    Int J Oncol 27:223-35. 2005
    ..These observations suggest the potential for application of u-PA/u-PAR system inhibitors for control of AIDS-associated KS, that has a high risk of recurrence with highly active antiretroviral therapy failure, and of other KS forms...
  55. ncbi request reprint Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate
    Raffaella Dell'eva
    Molecular Oncology, National Cancer Research Institute IST, Largo Rosanna Benzi 10, 16132 Genova, Italy
    Biochem Pharmacol 68:2359-66. 2004
    ..As a low-cost drug, it might be of particular interest for areas of Kaposi's sarcoma endemics. ART could be useful for the prevention of tumor angiogenesis...
  56. ncbi request reprint Tumor inflammatory angiogenesis and its chemoprevention
    Adriana Albini
    National Institute for Research on Cancer IST, Genoa, Italy
    Cancer Res 65:10637-41. 2005
    ..We propose chemoprevention of inflammatory angiogenesis as a way of checking the cancer before it progresses...
  57. ncbi request reprint Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma
    Francesca Spinella
    Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Via delle Messi d oro, 156, 00158 Rome, Italy
    Mol Cancer Ther 5:1483-92. 2006
    ....
  58. ncbi request reprint N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP
    Armando Rossello
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Pisa, Via Bonanno, 6, 56126 Pisa, Italy
    Bioorg Med Chem Lett 15:1321-6. 2005
    ..The simultaneous inhibition of these two enzymes yields type C compounds, which are potent antiangiogenic agents, able to block a chemoinvasion model on HUVEC cells in the micromolar range...
  59. ncbi request reprint AAV-mediated gene transfer of tissue inhibitor of metalloproteinases-1 inhibits vascular tumor growth and angiogenesis in vivo
    Serena Zacchigna
    Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    Cancer Gene Ther 11:73-80. 2004
    ..These results indicate that transfer and overexpression of the Timp1 gene is a promising therapeutic strategy to target tumor-associated angiogenesis in cancer gene therapy...
  60. ncbi request reprint Inhibition of Kaposi's sarcoma in vivo by fenretinide
    Nicoletta Ferrari
    Molecular Oncology Laboratory, the National Institute for Cancer Research, Genova, Italy
    Clin Cancer Res 9:6020-9. 2003
    ..We examined the effects of fenretinide [N-(4-hydroxyphenyl)retinamide; (4HPR)] on highly angiogenic Kaposi's sarcoma tumors in vivo and investigated the mechanisms involved for potential clinical applications...
  61. ncbi request reprint The transforming growth factor-beta family members bone morphogenetic protein-2 and macrophage inhibitory cytokine-1 as mediators of the antiangiogenic activity of N-(4-hydroxyphenyl)retinamide
    Nicoletta Ferrari
    Molecular Oncology Laboratory, National Institute for Cancer Research, Genova, Italy
    Clin Cancer Res 11:4610-9. 2005
    ..N-(4-hydroxyphenyl)retinamide (fenretinide; 4HPR) has been found to inhibit and/or prevent tumor growth under diverse conditions. Although 4HPR is antiangiogenic, the molecular mechanisms of this effect remain largely unknown...
  62. ncbi request reprint Biological assays and genomic analysis reveal lipoic acid modulation of endothelial cell behavior and gene expression
    Patrizia Larghero
    Centro di Biotecnologie Avanzate, Genova, Italy
    Carcinogenesis 28:1008-20. 2007
    ..According to our data, LA has promising anti-angiogenic properties, though its influence on central metabolic pathways should suggest more caution about its widespread and not prescribed use at pharmacological doses...
  63. ncbi request reprint Mechanisms of inhibition of tumor angiogenesis and vascular tumor growth by epigallocatechin-3-gallate
    Gianfranco Fassina
    Tumor Progression Unit and Molecular Oncology Lab, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Clin Cancer Res 10:4865-73. 2004
    ..Here, we examined the effects of this compound on the two key cell populations typically involved in tumor growth: tumor cells and endothelial cells...
  64. ncbi request reprint Cell density-dependent regulation of matrix metalloproteinase and TIMP expression in differently tumorigenic breast cancer cell lines
    Beatrice E Bachmeier
    Department Clinical Chemistry and Clinical Biochemistry, Hospital of Surgery, Ludwig Maximilians University, Nussbaumstr 20, D 80336 MUnchen, Germany
    Exp Cell Res 305:83-98. 2005
    ..Our data provide clear evidence that cell density regulates major MMPs and TIMPs which are controlled by AP-1 activity so that ultimately a major regulation pathway for the control of the invasive potential of tumor cells is presented...
  65. ncbi request reprint The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells
    Alfonso Baldi
    Laboratory C, CRS, Regina Elena Cancer Institute, Rome, Italy
    Oncogene 21:6684-8. 2002
    ..These results suggest that down-regulation of PRSS11 and HtrA1 expression may represent an indicator of melanoma progression...
  66. ncbi request reprint Tumors and inflammatory infiltrates: friends or foes?
    Claudio Brigati
    Molecular Biology Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Clin Exp Metastasis 19:247-58. 2002
    ..Lancet 2001; 357: 539-45), by focussing more specifically to the relation between inflammation and tumor invasion and how this could drive rational therapeutic approaches...
  67. ncbi request reprint In vitro and in vivo tumor growth inhibition by a p16-mimicking peptide in p16INK4A-defective, pRb-positive human melanoma cells
    Douglas M Noonan
    Tumor Progression Section, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, Genova, Italy
    J Cell Physiol 202:922-8. 2005
    ....
  68. ncbi request reprint HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells
    Maria Chiara Deregibus
    Cattedra di Nefrologia, Dipartimento di Medicina Interna Università di Torino, Centro Ricerca Medicina Sperimentale CeRMS, Italy
    J Biol Chem 277:25195-202. 2002
    ....
  69. ncbi request reprint CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A
    Patrizia Scapini
    Department of Pathology, Section of General Pathology, University of Verona, Verona, Italy
    J Immunol 172:5034-40. 2004
    ..Our observations delineate a novel mechanism by which CXCL1/MIP-2 induces neutrophil-dependent angiogenesis in vivo...
  70. ncbi request reprint Anti-invasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases
    Roberto Benelli
    Centro di Biotecnologie Avanzate, Genova, Italy
    Biol Chem 383:101-5. 2002
    ..In this brief review we focus on the inhibitory activity of catechins derived from green tea toward proteases involved in tumor invasion...
  71. ncbi request reprint Neutrophils as a key cellular target for angiostatin: implications for regulation of angiogenesis and inflammation
    Roberto Benelli
    Centro di Biotecnologie Avanzate, 16132 Genova, Italy
    FASEB J 16:267-9. 2002
    ..These data show that angiostatin directly inhibits neutrophil migration and neutrophil-mediated angiogenesis and indicate that angiostatin might inhibit inflammation...
  72. ncbi request reprint Identification of genes selectively regulated by IFNs in endothelial cells
    Stefano Indraccolo
    Department of Oncology and Surgical Sciences, Istituto Oncologico Veneto, Via Gattemelata 64, I 35128 Padua, Italy
    J Immunol 178:1122-35. 2007
    ..Moreover, we suggest that quantitative differences in the magnitude of the transcriptional activation of IFN-responsive genes could form the basis for cell-specific transcriptional signatures...
  73. ncbi request reprint Transient modulation of cytoplasmic and nuclear retinoid receptors expression in differentiating human teratocarcinoma NT2 cells
    Roberta Borghi
    Laboratory of Molecular Biology, National Cancer Research Institute IST, Genova, Italy
    J Neurochem 84:94-104. 2003
    ..These data suggest that the RA-specific induction of CRBP-I and CRABP-II could be an early event in the process leading to neuronal differentiation of NT2 cells...
  74. ncbi request reprint Molecular mechanisms of action of angiopreventive anti-oxidants on endothelial cells: microarray gene expression analyses
    Ulrich Pfeffer
    Functional Genomics Unit, National Cancer Research Institute, Genova, Italy
    Mutat Res 591:198-211. 2005
    ..Down-regulation of the TNFalpha responsive pro-metastatic, pro-inflammatory genes, urokinase plasminogen activator and selectin E, further implies anti-metastatic effects for these drugs...
  75. ncbi request reprint Antiangiogenic activity of the MDM2 antagonist nutlin-3
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Circ Res 100:61-9. 2007
    ....
  76. ncbi request reprint Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis
    Raffaele Niero
    Department of Experimental Biomedical Sciences, Medical School, Padova, Italy
    J Pharmacol Exp Ther 321:492-500. 2007
    ..These results indicate that Hyp is a powerful anti-inflammatory compound with therapeutic potential, and they elucidate mechanistic keys...
  77. ncbi request reprint The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-kappaB pathway
    Claudia Ambrosini
    Molecular Oncology Laboratory, National Institute for Cancer Research Largo R Benzi 10, Italy
    Carcinogenesis 28:404-13. 2007
    ..These findings reveal a new therapeutic potential for deguelin in angioprevention and anti-angiogenic therapy...
  78. ncbi request reprint Choking hypoxia-inducible factor 1alpha: a novel mechanism for connective tissue growth factor inhibition of angiogenesis
    Francesca Tosetti
    J Natl Cancer Inst 98:946-8. 2006
  79. ncbi request reprint Transcriptional control of cell density dependent regulation of matrix metalloproteinase and TIMP expression in breast cancer cell lines
    Beatrice E Bachmeier
    Dept of Clinical Chemistry and Clinical Biochemistry, Surgical Hospital, Ludwig Maximilians University, Nussbaumstr 20, D 80336 MUnchen, Germany
    Thromb Haemost 93:761-9. 2005
    ..Overexpression of MMPs in sparse cultures could help explain early dissemination of potentially metastatic cells...
  80. ncbi request reprint Re: Microarray studies challenge theories of metastasis
    Ulrich Pfeffer
    J Natl Cancer Inst 95:829. 2003
  81. ncbi request reprint Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS
    Debora Giunti
    Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
    J Leukoc Biol 73:584-90. 2003
    ..These cells are recruited into the CSF by inducible chemokines. Thus, CSF represents a transitional station for T cells trafficking to and from the NS...
  82. ncbi request reprint Generation of biologically active angiostatin kringle 1-3 by activated human neutrophils
    Patrizia Scapini
    Section of General Pathology, Department of Pathology, University of Verona, Verona, Italy
    J Immunol 168:5798-804. 2002
    ....
  83. ncbi request reprint A WT1 expressing metastatic human Kaposi sarcoma xenograft model
    Erzsebet Raso
    Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
    Pathol Oncol Res 10:22-5. 2004
    ..WT1 expression in the peripheral blood was only detectable in case of metastatic KS model suggesting it as a molecular marker of progression...
  84. ncbi request reprint Natural and synthetic agents targeting inflammation and angiogenesis for chemoprevention of prostate cancer
    Elena M V Araldi
    Department Experimental Biomedical Sciences, Medical School of Padova, Italy
    Curr Cancer Drug Targets 8:146-55. 2008
    ..The search for compounds with few or no adverse effects - particularly cardiovascular - as compared with the agents currently in use is therefore of greatest relevance...
  85. doi request reprint Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268
    Karen Liby
    Department of Pharmacology, Dartmouth Medical School, Hanover, NH 03755, USA
    Clin Cancer Res 14:4556-63. 2008
    ....
  86. ncbi request reprint 28th meeting of the Italian Cancer Society (SIC). New challenges of molecular oncology
    Pier Luigi Lollini
    Tumori 88:77-81. 2002