G Tedeschi

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. ncbi request reprint Pattern and significance of white matter abnormalities in myotonic dystrophy type 1: an MRI study
    Alfonso Di Costanzo
    Department of Neurological Sciences, Second University of Naples, Piazza L Miraglia, 2, 80138 Naples, Italy
    J Neurol 249:1175-82. 2002
  2. pmc Widespread structural and functional connectivity changes in amyotrophic lateral sclerosis: insights from advanced neuroimaging research
    Francesca Trojsi
    Department of Neurological Sciences, Second University of Naples, Piazza Miraglia 2, 80138 Naples, Italy
    Neural Plast 2012:473538. 2012
  3. doi request reprint The role of BOLD-fMRI in elucidating migraine pathophysiology
    G Tedeschi
    Headache Center, Department of Neurology, Second University of Naples, Naples, Italy
    Neurol Sci 34:S47-50. 2013
  4. doi request reprint Relevance of functional neuroimaging studies for understanding migraine mechanisms
    Gioacchino Tedeschi
    Headache Center, Department of Neurology, Second University of Naples, Naples, Italy
    Expert Rev Neurother 13:275-85. 2013
  5. doi request reprint Functional neuroimaging in migraine: usefulness for the clinical neurologist
    Gioacchino Tedeschi
    Clinica Neurologica II, Seconda Universita degli Studi di Napoli, Naples, Italy
    Neurol Sci 33:S91-4. 2012
  6. pmc Sporadic ALS is not associated with VAPB gene mutations in Southern Italy
    Francesca Luisa Conforti
    Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    J Negat Results Biomed 5:7. 2006
  7. doi request reprint The pharmacovigilance program on natalizumab in Italy: 2 years of experience
    G Tedeschi
    Dipartimento di Scienze Neurologiche, Seconda Università di Napoli e Istituto Hermitage Capodimonte, Naples, Italy
    Neurol Sci 30:S163-5. 2009
  8. ncbi request reprint Multiple sclerosis patients and immunomodulation therapies: the potential role of new MRI techniques to assess responders versus non-responders
    G Tedeschi
    II Division of Neurology, Department of Neurological Sciences, Second University of Naples, Piazza Miraglia 2, I 80138 Naples, Italy
    Neurol Sci 26:S209-12. 2005
  9. doi request reprint Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study
    G Tedeschi
    Department of Neurological Sciences, Second University of Naples, Naples, Italy
    Mult Scler 15:204-11. 2009
  10. doi request reprint Alzheimer's disease and other dementing conditions
    Gioacchino Tedeschi
    Department of Neurological Sciences, Second University of Naples, Piazza Miraglia 2, 80131 Naples, Italy
    Neurol Sci 29:301-7. 2008

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Pattern and significance of white matter abnormalities in myotonic dystrophy type 1: an MRI study
    Alfonso Di Costanzo
    Department of Neurological Sciences, Second University of Naples, Piazza L Miraglia, 2, 80138 Naples, Italy
    J Neurol 249:1175-82. 2002
    ....
  2. pmc Widespread structural and functional connectivity changes in amyotrophic lateral sclerosis: insights from advanced neuroimaging research
    Francesca Trojsi
    Department of Neurological Sciences, Second University of Naples, Piazza Miraglia 2, 80138 Naples, Italy
    Neural Plast 2012:473538. 2012
    ..This paper reviews the current state of knowledge concerning the neuropsychological and neuropathological sequelae of TDP-43 proteinopathies, with special focus on the neuroimaging findings associated with cognitive change in ALS...
  3. doi request reprint The role of BOLD-fMRI in elucidating migraine pathophysiology
    G Tedeschi
    Headache Center, Department of Neurology, Second University of Naples, Naples, Italy
    Neurol Sci 34:S47-50. 2013
    ..The purpose of this review is to present a synthesis of recent BOLD-fMRI studies which have allowed us to elucidate the complex process involved in migraine pathophysiology...
  4. doi request reprint Relevance of functional neuroimaging studies for understanding migraine mechanisms
    Gioacchino Tedeschi
    Headache Center, Department of Neurology, Second University of Naples, Naples, Italy
    Expert Rev Neurother 13:275-85. 2013
    ..Hopefully, a more detailed picture of the migraine neurobiology will emerge from future neuroimaging studies, which may eventually lead to better and more rational treatments...
  5. doi request reprint Functional neuroimaging in migraine: usefulness for the clinical neurologist
    Gioacchino Tedeschi
    Clinica Neurologica II, Seconda Universita degli Studi di Napoli, Naples, Italy
    Neurol Sci 33:S91-4. 2012
    ....
  6. pmc Sporadic ALS is not associated with VAPB gene mutations in Southern Italy
    Francesca Luisa Conforti
    Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    J Negat Results Biomed 5:7. 2006
    ..The frequency of the detected exon variation in the VAPB gene was not significantly different between patients and controls. In conclusion, our study suggests that VAPB mutations are not a common cause of adult-onset SALS...
  7. doi request reprint The pharmacovigilance program on natalizumab in Italy: 2 years of experience
    G Tedeschi
    Dipartimento di Scienze Neurologiche, Seconda Università di Napoli e Istituto Hermitage Capodimonte, Naples, Italy
    Neurol Sci 30:S163-5. 2009
    ..Treatment was well tolerated and side effects were similar to those reported in the registrative studies. The majority of treated cases are stable or ameliorated...
  8. ncbi request reprint Multiple sclerosis patients and immunomodulation therapies: the potential role of new MRI techniques to assess responders versus non-responders
    G Tedeschi
    II Division of Neurology, Department of Neurological Sciences, Second University of Naples, Piazza Miraglia 2, I 80138 Naples, Italy
    Neurol Sci 26:S209-12. 2005
    ....
  9. doi request reprint Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study
    G Tedeschi
    Department of Neurological Sciences, Second University of Naples, Naples, Italy
    Mult Scler 15:204-11. 2009
    ..To investigate in a large cohort of patients with multiple sclerosis (MS), lesion load and atrophy evolution, and the relationship between clinical and magnetic resonance imaging (MRI) correlates of disease progression...
  10. doi request reprint Alzheimer's disease and other dementing conditions
    Gioacchino Tedeschi
    Department of Neurological Sciences, Second University of Naples, Piazza Miraglia 2, 80131 Naples, Italy
    Neurol Sci 29:301-7. 2008
    ..This review will focus on the use of conventional and non-conventional MRI techniques to investigate dementias...
  11. ncbi request reprint Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability
    Gioacchino Tedeschi
    Department of Neurological Sciences, Second University of Naples, Naples, Italy
    J Neurol Sci 263:15-9. 2007
    ..Fatigue is a major problem in multiple sclerosis (MS), and its association with MRI features is debated...
  12. ncbi request reprint Proton MR spectroscopic imaging in multiple sclerosis
    G Tedeschi
    Istituto di Scienze Neurologiche, Seconda Universita di Napoli, Italy
    Neuroradiology 44:37-42. 2002
    ..1H-MRSI was compatible with damage to myelin in WML, and with axonal damage and/or dysfunction in WML and NAWM. These findings extend data on involvement of NAWM in MS beyond the abnormalities visible on MRI...
  13. ncbi request reprint Brain atrophy and lesion load in a large population of patients with multiple sclerosis
    G Tedeschi
    Department of Neurological Sciences, Second University of Naples, Piazza Miraglia 2, 80138 Naples, Italy
    Neurology 65:280-5. 2005
    ..To measure white matter (WM) and gray matter (GM) atrophy and lesion load in a large population of patients with multiple sclerosis (MS) using a fully automated, operator-independent, multiparametric segmentation method...
  14. doi request reprint Natalizumab is effective in multiple sclerosis patients switching from other disease modifying therapies in clinical practice
    R Lanzillo
    Neurological Sciences Department, Federico II University, Via Pansini 5, 80131 Naples, Italy
    Neurol Sci 34:521-8. 2013
    ..Natalizumab showed to decrease ARR, stabilize EDSS, increase the percentage of CELs free patients and decrease the number of CELs in a group of 50 poor responders to classical DMT, after the first 12 months of therapy...
  15. ncbi request reprint Treatment of multiple sclerosis with interferon beta in clinical practice: 2-year follow-up data from the South Italy Mobile MRI Project
    S Bonavita
    Department of Neurological Sciences, Second University of Naples, Piazza Miraglia 2, I 80138 Naples, Italy
    Neurol Sci 27:S365-8. 2006
    ..Despite some limitations in the trial design, the results from this follow-up study provide helpful clinical and MRI data on the efficacy of interferon beta regimens in MS patients treated in the clinical setting...
  16. doi request reprint BDNF Val66Met polymorphism and brain volumes in multiple sclerosis
    D Dinacci
    Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy
    Neurol Sci 32:117-23. 2011
    ..The regression analysis showed that both Val/Met genotype and relapse number were associated with lower CSF-f. Our data suggest that Met allele might be a protective factor against MS as it is associated to a lower brain atrophy...
  17. ncbi request reprint T2 relaxometry of brain in myotonic dystrophy
    A Di Costanzo
    Institute of Neurological Sciences, Second University of Naples, Italy
    Neuroradiology 43:198-204. 2001
    ..White-matter involvement in DM is more extensive than previously reported by MRI and neuropathological studies and seems to be progressive in the course of disease...
  18. doi request reprint Frontotemporal cortical thinning in amyotrophic lateral sclerosis
    A D'Ambrosio
    From the Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences A d A, A G, F T, M R M, M C, G T, Second University of Naples, Naples, Italy
    AJNR Am J Neuroradiol 35:304-10. 2014
    ..In the present study, we assessed the spatial distribution of cortical damage in amyotrophic lateral sclerosis by using a cortical thickness measurement approach...
  19. doi request reprint Natalizumab vs interferon beta 1a in relapsing-remitting multiple sclerosis: a head-to-head retrospective study
    R Lanzillo
    Neurological Sciences Department, Federico II University, Naples, Italy
    Acta Neurol Scand 126:306-14. 2012
    ..No head-to-head study has been performed yet to assess whether natalizumab is more effective than classical immunomodulators in multiple sclerosis (MS)...
  20. ncbi request reprint Does the default-mode functional connectivity of the brain correlate with working-memory performances?
    F Esposito
    Department of Neuroscience, University of Naples Federico II, Naples, Italy
    Arch Ital Biol 147:11-20. 2009
    ....
  21. doi request reprint Widespread microstructural white matter involvement in amyotrophic lateral sclerosis: a whole-brain DTI study
    M Cirillo
    Department of Neurological Sciences, Second University of Naples, Naples, Italy
    AJNR Am J Neuroradiol 33:1102-8. 2012
    ..The present study aimed to detect WM patterns of microstructural abnormalities to better investigate the pathologic process in ALS, within but also beyond CSTs, in a whole-brain analysis...
  22. ncbi request reprint White matter lesion detection in multiple sclerosis: improved interobserver concordance with multispectral MRI display
    A Brunetti
    Diagnostic Imaging Department, CNR, Universita Federico II, Naples, Italy
    J Neurol 244:586-90. 1997
    ..56 for the neurologist), an increased number of detected lesions and decreased reading time. Multispectral maps permit easy detection of MS lesions and may improve interobserver concordance compared with conventional spinecho studies...
  23. doi request reprint Clinical and magnetic resonance imaging predictors of disease progression in multiple sclerosis: a nine-year follow-up study
    L Lavorgna
    Second University of Naples, II Clinic of Neurology, Italy
    Mult Scler 20:220-6. 2014
    ..The objective of this paper is to identify clinical or magnetic resonance imaging (MRI) predictors of long-term clinical progression in a large cohort of multiple sclerosis (MS) patients...
  24. ncbi request reprint Post-traumatic headaches: a clinical overview
    A Russo
    Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy
    Neurol Sci 35:153-6. 2014
    ..Recently, the International Classification of Headache Disorders attempted to classify PTH; however, many unsolved issues are still to be clarified. In this brief review, we will focus on PTH clinical aspects and diagnostic criteria. ..
  25. ncbi request reprint Subcortical motor plasticity in patients with sporadic ALS: An fMRI study
    A Tessitore
    Second Division of Neurology, Second University of Naples, Piazza Miraglia, 2, Naples 80131, Italy
    Brain Res Bull 69:489-94. 2006
    ....
  26. doi request reprint Regional gray matter atrophy in patients with Parkinson disease and freezing of gait
    A Tessitore
    Department of Neurological Sciences, Second University of Naples, Naples, Italy
    AJNR Am J Neuroradiol 33:1804-9. 2012
    ..FOG is a troublesome symptom of PD. Despite growing evidence suggesting that FOG in PD may be associated with cognitive dysfunction, the relationship between regional brain atrophy and FOG has been poorly investigated...
  27. doi request reprint Search for compensation postures with videofluoromanometric investigation in dysphagic patients affected by amyotrophic lateral sclerosis
    A Solazzo
    Sezione di Radiologia, Dipartimento Magrassi Lanzara, Seconda Universita di Napoli, Naples, Italy
    Radiol Med 116:1083-94. 2011
    ..This study was undertaken to verify the effectiveness of compensatory postures, suggested on the basis of the type of dysphagia identified at videofluoromanometric (VFM) investigation to ensure safe oropharyngeal transit...
  28. doi request reprint The GH-IGF system in amyotrophic lateral sclerosis: correlations between pituitary GH secretion capacity, insulin-like growth factors and clinical features
    M T Pellecchia
    Department of Neurological Sciences and Molecular, Federico II University, Naples, Italy
    Eur J Neurol 17:666-71. 2010
    ..Our aim was to investigate the GH-IGF axis in patients with ALS and evaluate correlations between this endocrine system and clinical features...
  29. doi request reprint Small animal imaging facility: new perspectives for the radiologist
    R Grassi
    Institute of Radiology, Neurological Sciences Department, Second University of Naples, Piazza Miraglia, 80138, Naples, Italy
    Radiol Med 114:152-67. 2009
    ..The aim of this article is to review the characteristics of these systems and illustrate their main applications...
  30. ncbi request reprint High-field proton MRS of human brain
    Alfonso Di Costanzo
    Department of Neurological Sciences, Second University of Naples, Piazza L Miraglia 2, 80138 Naples, Italy
    Eur J Radiol 48:146-53. 2003
    ..Several studies demonstrated that these limitations could be overcome, suggesting that the appropriate optimization of high-field 1H-MRS would expand the application in the fields of clinical research and diagnostic routine...
  31. ncbi request reprint A multiparametric brain and cord MR imaging study of a patient with Hirayama disease
    A Gallo
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    AJNR Am J Neuroradiol 27:2115-7. 2006
    ..Whereas this study suggests a more widespread cord involvement in HD than seen on routine MR imaging, its cause remains unclear (vascular damage versus a primary lower motor neuron disease)...
  32. ncbi request reprint Clinical and electrodiagnostic follow-up of an adolescent poisoned with thallium
    A Ammendola
    Department of Neurological Sciences, Second University of Naples, Piazza Miraglia 2, I 80138, Naples, Italy
    Neurol Sci 28:205-8. 2007
    ..These investigations allowed the authors to depict the electrophysiologic course of peripheral nervous system involvement over six years following poisoning...
  33. ncbi request reprint Dilated Virchow-Robin spaces in myotonic dystrophy: frequency, extent and significance
    A Di Costanzo
    Institute of Neurological Sciences, Second University of Naples, Italy
    Eur Neurol 46:131-9. 2001
    ..Dilated convexity VRSs might be one of the initial findings in cranial MRI of DM, preceding the appearance of lobar WMLs...
  34. ncbi request reprint Apolipoprotein E genotype does not influence the progression of multiple sclerosis
    Giovanni Savettieri
    Institute of Neuropsychiatry, University of Palermo, Palermo, Italy
    J Neurol 250:1094-8. 2003
    ..To investigate the association between apolipoprotein E (APOE) polymorphisms and the progression of MS...
  35. ncbi request reprint Brain MRI features of congenital- and adult-form myotonic dystrophy type 1: case-control study
    Alfonso Di Costanzo
    Department of Neurological Sciences, Second University of Naples, Piazza L Miraglia, Naples, Italy
    Neuromuscul Disord 12:476-83. 2002
    ..These results suggest that the origin of MRI abnormalities in myotonic dystrophy type 1 is mainly developmental for the congenital form and mainly degenerative for the adult form...
  36. ncbi request reprint Independent component model of the default-mode brain function: Assessing the impact of active thinking
    Fabrizio Esposito
    Department of Neurological Sciences, University of Naples Federico II, II Policlinico Nuovo Policlinico Padiglione 17, Via S Pansini 5, 80131 Naples, Italy
    Brain Res Bull 70:263-9. 2006
    ....
  37. ncbi request reprint Real-time independent component analysis of fMRI time-series
    Fabrizio Esposito
    Second Division of Neurology, Second University of Naples, 8013 Naples, Italy
    Neuroimage 20:2209-24. 2003
    ....
  38. doi request reprint Infratentorial progressive multifocal leukoencephalopathy in a patient treated with fludarabine and rituximab
    Simona Bonavita
    Department of Neurological Sciences, II University of Naples, Piazza Miraglia 2, 80138 Naples, Italy
    Neurol Sci 29:37-9. 2008
    ....
  39. ncbi request reprint Independent component analysis of fMRI group studies by self-organizing clustering
    Fabrizio Esposito
    Second Division of Neurology, Second University of Naples, Italy
    Neuroimage 25:193-205. 2005
    ..This property is particularly of interest for a blind group and subgroup pattern extraction and selection...
  40. ncbi request reprint Restless legs syndrome and primary headaches: a clinical study
    Florindo d'Onofrio
    Neurology Unit, SG Moscati Hospital Viale Italia, 83100 Avellino, Italy
    Neurol Sci 29:S169-72. 2008
    ..The absence of RLS in ECH patients is very interesting. Many pathogenetic considerations about links between RLS and primary headaches could be given, the most fitting involving dopamine and melatonin...
  41. ncbi request reprint Spatial independent component analysis of functional MRI time-series: to what extent do results depend on the algorithm used?
    Fabrizio Esposito
    Institute of Neurological Sciences, Second University of Naples, Italy
    Hum Brain Mapp 16:146-57. 2002
    ..Because of its adaptive nature, the Infomax approach appears to be better suited to investigate activation phenomena that are not predictable or adequately modelled by inferential techniques...
  42. ncbi request reprint Spatiotemporal pattern of neural processing in the human auditory cortex
    Erich Seifritz
    Department of Psychiatry, University of Basel, 4025 Basel, Switzerland
    Science 297:1706-8. 2002
    ..Converging with unit recordings, our data suggest that this spatiotemporal pattern in the auditory cortex may represent a fundamental principle of analyzing sound information...
  43. ncbi request reprint Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis
    Giovanni Savettieri
    Institute of Neuropsychiatry, University of Palermo, Palermo, Italy
    J Neurol 251:1208-14. 2004
    ..The APOE-epsilon4 allele is the major known genetic risk factor for late onset familial and sporadic Alzheimer's Disease (AD), and it seems to be implicated in cognitive decline in normal elderly persons...
  44. ncbi request reprint Diffuse neuroaxonal involvement in mucolipidosis IV as assessed by proton magnetic resonance spectroscopic imaging
    Simona Bonavita
    Second Division of Neurology, Second University of Naples, Italy
    J Child Neurol 18:443-9. 2003
    ..Mucolipin deficiency impairs motor more than sensory central nervous system pathways...
  45. doi request reprint Familial aggregation of white matter lesions in myotonic dystrophy type 1
    Alfonso Di Costanzo
    Department of Health Sciences, University of Molise, Via Giovanni Paolo II, 86100 Campobasso, Italy
    Neuromuscul Disord 18:299-305. 2008
    ..These findings suggest that other genetic causes and/or unknown environmental factors influence the occurrence and severity of lesions in patients carrying the DM1 genetic defect...
  46. ncbi request reprint Lack of association between estrogen receptor 1 gene polymorphisms and multiple sclerosis in southern Italy in humans
    Giovanni Savettieri
    Institute of Neurology, University of Palermo, Palermo, Italy
    Neurosci Lett 327:115-8. 2002
    ..This result suggests that the association between a given disease and a genomic characteristic must be confirmed by separate investigations in different populations...
  47. ncbi request reprint How does spatial extent of fMRI datasets affect independent component analysis decomposition?
    Adriana Aragri
    Second Division of Neurology, Second University of Naples, Naples, Italy
    Hum Brain Mapp 27:736-46. 2006
    ..This is consistent with the capability of sICA to take advantage of extended samples of statistical observations and suggests that sICA is more powerful with extended rather than reduced VOI datasets to delineate brain activity...