C Schiraldi


Affiliation: Second University of Naples
Country: Italy


  1. Schiraldi C, Cimini D, De Rosa M. Production of chondroitin sulfate and chondroitin. Appl Microbiol Biotechnol. 2010;87:1209-20 pubmed publisher
    ..In this paper we present an overview of the diverse applications and production methods of chondroitin reported so far in literature with a specific focus on novel microbial biotechnological approaches. ..
  2. request reprint
    Schiraldi C, Maresca C, Catapano A, Galinski E, De Rosa M. High-yield cultivation of Marinococcus M52 for production and recovery of hydroxyectoine. Res Microbiol. 2006;157:693-9 pubmed
    ..6 g l-1 of hydroxyectoine). Finally, we developed a novel extraction method based on osmotic down-shock coupled with thermal permeabilization to recover the desired products from the biomass. ..
  3. Cimini D, Carlino E, Giovane A, Argenzio O, Dello Iacono I, De Rosa M, et al. Engineering a branch of the UDP-precursor biosynthesis pathway enhances the production of capsular polysaccharide in Escherichia coli O5:K4:H4. Biotechnol J. 2015;10:1307-15 pubmed publisher
    ..coli K4, a complex unexplored aspect of a multifaceted process. ..
  4. Schiraldi C, Carcarino I, Alfano A, Restaino O, Panariello A, De Rosa M. Purification of chondroitin precursor from Escherichia coli K4 fermentation broth using membrane processing. Biotechnol J. 2011;6:410-9 pubmed publisher
    ..The complete downstream procedure yielded about 75% chondroitin with a purity higher than 90%. ..
  5. D Agostino A, Stellavato A, Busico T, Papa A, Tirino V, Papaccio G, et al. In vitro analysis of the effects on wound healing of high- and low-molecular weight chains of hyaluronan and their hybrid H-HA/L-HA complexes. BMC Cell Biol. 2015;16:19 pubmed publisher
    ..The outcomes of this research showed that, both at high and low concentrations, hybrid complexes proved to perform better than HA alone thus suggesting their potential as medical devices in aesthetic and regenerative medicine. ..
  6. Pirozzi A, Stellavato A, La Gatta A, Lamberti M, Schiraldi C. Mancozeb, a fungicide routinely used in agriculture, worsens nonalcoholic fatty liver disease in the human HepG2 cell model. Toxicol Lett. 2016;249:1-4 pubmed publisher
    ..Therefore, mancozeb may play an important role in the pathogenesis and progression of chronic disease in humans and represents a danger for human health in high doses. ..
  7. La Gatta A, De Rosa M, Frezza M, Catalano C, Meloni M, Schiraldi C. Biophysical and biological characterization of a new line of hyaluronan-based dermal fillers: A scientific rationale to specific clinical indications. Mater Sci Eng C Mater Biol Appl. 2016;68:565-572 pubmed publisher
    ..These data predicted a better performance regarding hydro-action, tissue integration, clinical management during delivery, and a high durability of the aesthetic effect when compared to data on marketed similar products. ..
  8. Cimini D, Corte K, Finamore R, Andreozzi L, Stellavato A, Pirozzi A, et al. Production of human pro-relaxin H2 in the yeast Pichia pastoris. BMC Biotechnol. 2017;17:4 pubmed publisher
  9. Schiraldi C, Alfano A, Cimini D, Panariello A, Restaino O, Rosa M. Application of a 22L scale membrane bioreactor and cross-flow ultrafiltration to obtain purified chondroitin. Biotechnol Prog. 2012;28:1012-8 pubmed publisher
    ..coli O5:K4:H4. The complete downstream procedure yielded about 80% chondroitin with 90% purity. ..

More Information


  1. Restaino O, Finamore R, Diana P, Marseglia M, Vitiello M, Casillo A, et al. A multi-analytical approach to better assess the keratan sulfate contamination in animal origin chondroitin sulfate. Anal Chim Acta. 2017;958:59-70 pubmed publisher
    ..High molecular weight species (>100 KDa) were also present in the samples that counted for chains still partially linked to a proteoglycan core. ..
  2. La Gatta A, Ricci G, Stellavato A, Cammarota M, Filosa R, Papa A, et al. Hyaluronan hydrogels with a low degree of modification as scaffolds for cartilage engineering. Int J Biol Macromol. 2017;103:978-989 pubmed publisher
    ..They also secreted cartilage-specific matrix proteins. These scaffolds represent promising candidates for cartilage engineering. ..
  3. Salzillo R, Schiraldi C, Corsuto L, D Agostino A, Filosa R, De Rosa M, et al. Optimization of hyaluronan-based eye drop formulations. Carbohydr Polym. 2016;153:275-283 pubmed publisher
    ..An enhanced capacity to protect corneal porcine epithelial cells from dehydration is also demonstrated in vitro. Overall, the results predict formulations with improved efficacy. ..
  4. D Agostino A, Stellavato A, Corsuto L, Diana P, Filosa R, La Gatta A, et al. Is molecular size a discriminating factor in hyaluronan interaction with human cells?. Carbohydr Polym. 2017;157:21-30 pubmed publisher
    ..Finally our outcomes showed that the lower the fragment size the higher the concern for inflammatory cytokines up-regulation; repair process impairment was highlighted only for 6kDa chains. ..
  5. Restaino O, Borzacchiello M, Scognamiglio I, Porzio E, Manco G, Fedele L, et al. Boosted large-scale production and purification of a thermostable archaeal phosphotriesterase-like lactonase for organophosphate decontamination. J Ind Microbiol Biotechnol. 2017;44:363-375 pubmed publisher
    ..5 up to 150 L. By coupling a single thermo-precipitation step and an ultrafiltration process, a total enzyme recovery of 77% with a purity grade of almost 80% was reached. ..
  6. Di Lorenzo F, Silipo A, Molinaro A, Parrilli M, Schiraldi C, D Agostino A, et al. The polysaccharide and low molecular weight components of Opuntia ficus indica cladodes: Structure and skin repairing properties. Carbohydr Polym. 2017;157:128-136 pubmed publisher
    ..The results showed that the whole Opuntia mucilage and the low molecular weight components are active in the wound repair. ..