E Sagnelli

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. pmc Access to treatment for HBV infection and its consistency with 2008 European guidelines in a multicentre cross-sectional study of HIV/HBV co-infected patients in Italy
    Giorgio Antonucci
    Italian Society of Infectious and Tropical Diseases, Florence, Italy
    BMC Res Notes 6:153. 2013
  2. doi request reprint Clinical presentation, outcome, and response to therapy among patients with acute exacerbation of chronic hepatitis C
    Evangelista Sagnelli
    Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Naples, Italy
    Clin Gastroenterol Hepatol 11:1174-1180.e11. 2013
  3. pmc Efficacy of Pegylated interferon α-2a and α-2b in patients with genotype 1 chronic hepatitis C: a meta-analysis
    Nicola Coppola
    Department of Public Medicine, Section of Infectious Diseases, Second University of Naples, Naples, Italy
    BMC Infect Dis 12:357. 2012
  4. doi request reprint Clinical applications of antibody avidity and immunoglobulin M testing in acute HCV infection
    Evangelista Sagnelli
    Department of Public Medicine, Section of Infectious Diseases, Second University of Naples, Italy
    Antivir Ther 17:1453-8. 2012
  5. ncbi request reprint Blood born viral infections, sexually transmitted diseases and latent tuberculosis in italian prisons: a preliminary report of a large multicenter study
    E Sagnelli
    Department of Mental Health and Public Medicine, Second University of Naples, Naples, Italy
    Eur Rev Med Pharmacol Sci 16:2142-6. 2012
  6. pmc Rituximab-based treatment, HCV replication, and hepatic flares
    Evangelista Sagnelli
    Section of Infectious Diseases, Department of Public Medicine, Second University of Naples, 80131 Naples, Italy
    Clin Dev Immunol 2012:945950. 2012
  7. pmc Impact of comorbidities on the severity of chronic hepatitis B at presentation
    Evangelista Sagnelli
    Department of Public Medicine, Section of Infectious Diseases, Second University of Naples, 80132 Naples, Italy
    World J Gastroenterol 18:1616-21. 2012
  8. ncbi request reprint Influence of chronic coinfection with hepatitis B and C virus on liver histology
    E Sagnelli
    Division of Infectious Diseases, San Sebastian Hospital and the Dept of Public Medicine, Second University of Naples, Hospital Gesù and Maria, Italy
    Infection 32:144-8. 2004
  9. ncbi request reprint Liver histology in patients with HBsAg negative anti-HBc and anti-HCV positive chronic hepatitis
    Evangelista Sagnelli
    Department of Public Medicine, Division of Infectious Diseases, Second University of Naples, San Sebastiano Hospital, Caserta, Italy
    J Med Virol 75:222-6. 2005
  10. ncbi request reprint The importance of HCV on the burden of chronic liver disease in Italy: a multicenter prevalence study of 9,997 cases
    Evangelista Sagnelli
    Infectious Disease Unit, Department of Public Medicine, 2nd University of Naples, c o Ospedale Gesù e Maria, Via D Cotugno 1, 80135 Naples, Italy
    J Med Virol 75:522-7. 2005

Collaborators

Detail Information

Publications50

  1. pmc Access to treatment for HBV infection and its consistency with 2008 European guidelines in a multicentre cross-sectional study of HIV/HBV co-infected patients in Italy
    Giorgio Antonucci
    Italian Society of Infectious and Tropical Diseases, Florence, Italy
    BMC Res Notes 6:153. 2013
    ....
  2. doi request reprint Clinical presentation, outcome, and response to therapy among patients with acute exacerbation of chronic hepatitis C
    Evangelista Sagnelli
    Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Naples, Italy
    Clin Gastroenterol Hepatol 11:1174-1180.e11. 2013
    ..We aimed to provide more information about the clinical presentation of acute exacerbation of CHC...
  3. pmc Efficacy of Pegylated interferon α-2a and α-2b in patients with genotype 1 chronic hepatitis C: a meta-analysis
    Nicola Coppola
    Department of Public Medicine, Section of Infectious Diseases, Second University of Naples, Naples, Italy
    BMC Infect Dis 12:357. 2012
    ..The purpose of this meta-analysis was to assess the efficacy of Peg-IFN α-2a versus Peg-IFN α-2b in combination with ribavirin in anti-human immunodeficiency virus (HIV)-negative patients with genotype 1 chronic HCV infection...
  4. doi request reprint Clinical applications of antibody avidity and immunoglobulin M testing in acute HCV infection
    Evangelista Sagnelli
    Department of Public Medicine, Section of Infectious Diseases, Second University of Naples, Italy
    Antivir Ther 17:1453-8. 2012
    ..Our studies, reviewed here, show that testing for antibody avidity and anti-HCV immunoglobulin M allow diagnosis in up to 90% of cases of acute hepatitis C...
  5. ncbi request reprint Blood born viral infections, sexually transmitted diseases and latent tuberculosis in italian prisons: a preliminary report of a large multicenter study
    E Sagnelli
    Department of Mental Health and Public Medicine, Second University of Naples, Naples, Italy
    Eur Rev Med Pharmacol Sci 16:2142-6. 2012
    ..Recent screenings of inmates for Hepatitis C virus (HCV), Hepatitis B virus (HBV), human immunodeficiency virus (HIV), Syphilis and Latent Tuberculosis (LTB) did not provide sufficient information to improve healthcare strategies...
  6. pmc Rituximab-based treatment, HCV replication, and hepatic flares
    Evangelista Sagnelli
    Section of Infectious Diseases, Department of Public Medicine, Second University of Naples, 80131 Naples, Italy
    Clin Dev Immunol 2012:945950. 2012
    ..These studies suggest that the hepatic flares are frequently asymptomatic, but life-threatening liver failure occurs in nearly 10% of cases...
  7. pmc Impact of comorbidities on the severity of chronic hepatitis B at presentation
    Evangelista Sagnelli
    Department of Public Medicine, Section of Infectious Diseases, Second University of Naples, 80132 Naples, Italy
    World J Gastroenterol 18:1616-21. 2012
    ..To evaluate the clinical relevance of each cofactor on clinical presentation of chronic hepatitis B...
  8. ncbi request reprint Influence of chronic coinfection with hepatitis B and C virus on liver histology
    E Sagnelli
    Division of Infectious Diseases, San Sebastian Hospital and the Dept of Public Medicine, Second University of Naples, Hospital Gesù and Maria, Italy
    Infection 32:144-8. 2004
    ..Few data are available on histological features of chronic hepatitis B (HBV) and C (HCV) virus coinfection...
  9. ncbi request reprint Liver histology in patients with HBsAg negative anti-HBc and anti-HCV positive chronic hepatitis
    Evangelista Sagnelli
    Department of Public Medicine, Division of Infectious Diseases, Second University of Naples, San Sebastiano Hospital, Caserta, Italy
    J Med Virol 75:222-6. 2005
    ....
  10. ncbi request reprint The importance of HCV on the burden of chronic liver disease in Italy: a multicenter prevalence study of 9,997 cases
    Evangelista Sagnelli
    Infectious Disease Unit, Department of Public Medicine, 2nd University of Naples, c o Ospedale Gesù e Maria, Via D Cotugno 1, 80135 Naples, Italy
    J Med Virol 75:522-7. 2005
    ..However, a comparison between the prevalent and incident cases suggests that in future HCV infection will also play a progressively decreasing role, in part as a consequence of treatment...
  11. ncbi request reprint Diagnosis of hepatitis C virus related acute hepatitis by serial determination of IgM anti-HCV titres
    Evangelista Sagnelli
    Division of Infectious Diseases, Azienda Ospedaliera San Sebastiano, Caserta, Italy
    J Hepatol 42:646-51. 2005
    ..We investigated whether serial determination of IgM to HCV core protein (HCV IgM) may be useful to identify acute hepatitis C (AHC) and to distinguish this disease from reactivation of chronic hepatitis C (r-CHC)...
  12. doi request reprint HBV superinfection in HCV chronic carriers: a disease that is frequently severe but associated with the eradication of HCV
    Evangelista Sagnelli
    Department of Public Medicine, Section of Infectious Diseases, 2nd University of Naples, Naples, Italy
    Hepatology 49:1090-7. 2009
    ..3% versus 22.2%, P < 0.05)...
  13. doi request reprint Virological and epitope evolution of HCV infection from acute hepatitis C to subsequent episodes of HCV-related acute liver cell necrosis
    E Sagnelli
    Department of Public Medicine, Section of Infectious Diseases, Second University of Naples, c o Ospedale Gesù e Maria, Via D Cotugno 1, Naples, Italy
    Infection 37:344-8. 2009
    ..To evaluate the virological and clinical events occurring during a 3-year follow-up in three patients who, after symptomatic acute hepatitis C (AHC), experienced subsequent episodes of HC virus (V)-related acute liver cell necrosis...
  14. ncbi request reprint Clinical and virological improvement of hepatitis B virus-related or hepatitis C virus-related chronic hepatitis with concomitant hepatitis A virus infection
    Evangelista Sagnelli
    Division of Infectious Diseases, Azienda Ospedaliera San Sebastiano, Caserta, Italy
    Clin Infect Dis 42:1536-43. 2006
    ..We evaluated the clinical and virological characteristics of hepatitis A virus infection in persons concomitantly infected with hepatitis B virus (HBV) or hepatitis C virus (HCV)...
  15. ncbi request reprint Diagnosis of HCV related acute hepatitis by serial determination of IgM to HCV: a preliminary observation
    E Sagnelli
    Division of Infectious Diseases, Azienda Ospedaliera San Sebastiano, Caserta, Italy
    J Biol Regul Homeost Agents 17:207-10. 2003
    ....
  16. ncbi request reprint HAV replication in acute hepatitis with typical and atypical clinical course
    Evangelista Sagnelli
    Division of Infectious Diseases, Azienda Ospedaliera San Sebastiano, Caserta, Italy
    J Med Virol 71:1-6. 2003
    ..The data also suggest that the detection of plasma HAV RNA after 20 days of illness may predict a prolonged course of the disease, but relapsing hepatitis remains unpredictable on the basis of plasma HAV determination...
  17. ncbi request reprint Virologic and clinical expressions of reciprocal inhibitory effect of hepatitis B, C, and delta viruses in patients with chronic hepatitis
    E Sagnelli
    Institute of Infectious Diseases, Second University of Naples, Naples, Italy
    Hepatology 32:1106-10. 2000
    ..Thus, in multiple hepatitis we observed a reciprocal inhibition of the viral genomes and a more severe liver disease. In Case group b-C, serum HBV DNA was frequent and the clinical presentation was severe...
  18. doi request reprint Chronic hepatitis B in Italy: new features of an old disease--approaching the universal prevalence of hepatitis B e antigen-negative cases and the eradication of hepatitis D infection
    Evangelista Sagnelli
    Infectious Disease Unit, Second University of Naples, Naples, Italy
    Clin Infect Dis 46:110-3. 2008
    ..8%. Multiple logistic regression analysis showed that age >49 years, alcohol abuse, and anti-hepatitis D virus and anti-hepatitis C virus positivity were independent predictors of progression to liver cirrhosis...
  19. doi request reprint Diagnosis and clinical impact of occult hepatitis B infection in patients with biopsy proven chronic hepatitis C: a multicenter study
    Evangelista Sagnelli
    Department of Public Medicine, Second University of Naples, Naples, Italy
    J Med Virol 80:1547-53. 2008
    ....
  20. ncbi request reprint Exposure to HAV infection in patients with chronic liver disease in Italy, a multicentre study
    E Sagnelli
    Section of Infectious Diseases, Department of Medicine and Public Health, Second University of Naples, Naples, Italy
    J Viral Hepat 13:67-71. 2006
    ..6%, P < 0.0001). The high prevalence of patients in Italy with chronic hepatitis or cirrhosis who lack naturally acquired immunity to HAV warrants the implementation of vaccination programmes against hepatitis A in such patients...
  21. ncbi request reprint HBV superinfection in hepatitis C virus chronic carriers, viral interaction, and clinical course
    Evangelista Sagnelli
    Division of Infectious Diseases, Azienda Ospedaliera di Caserta, Naples, Italy
    Hepatology 36:1285-91. 2002
    ..In conclusion, HBV superinfection in chronic HCV carriers has a severe clinical course and strongly and persistently depresses HCV...
  22. ncbi request reprint Hepatitis C virus superinfection in hepatitis B virus chronic carriers: a reciprocal viral interaction and a variable clinical course
    Evangelista Sagnelli
    Division of Infectious Diseases, San Sebastiano Hospital, Caserta, Italy
    J Clin Virol 35:317-20. 2006
    ..The virological and clinical impact of hepatitis C virus (HCV) superinfection in chronic hepatitis B virus (HBV) carriers has been poorly characterized...
  23. ncbi request reprint HCV genotype and "silent" HBV coinfection: two main risk factors for a more severe liver disease
    E Sagnelli
    Institute of Infectious Diseases, Second University of Naples, Naples, Italy
    J Med Virol 64:350-5. 2001
    ..Evidence was also found that in patients without "silent" HBV infection there is a correlation between the presence of HCV genotype 1 and the severity of liver disease...
  24. ncbi request reprint Isolated anti-HBc in chronic hepatitis C predicts a poor response to interferon treatment
    E Sagnelli
    Institute of Infectious Diseases, Second University of Naples, Naples, Italy
    J Med Virol 65:681-7. 2001
    ..3% for genotype 1 and 7.1% for other genotypes). The data indicate that patients with HCV chronic hepatitis and isolated anti-HBc show a poor response to IFN-alpha, irrespective of the HCV genotype...
  25. doi request reprint Tolerability and efficacy of anti-HBV nucleos(t)ide analogues in HBV-DNA-positive cirrhotic patients with HBV/HCV dual infection
    N Coppola
    Department of Public Medicine, Second University of Naples, Naples, Italy
    J Viral Hepat 19:890-6. 2012
    ..Treatment with nucleotides in HBsAg/HBV-DNA/anti-HCV-positive patients with cirrhosis showed a favourable virological effect in all cases, but a favourable clinical result only in the HCV-RNA-negative at baseline...
  26. ncbi request reprint Does HIV infection favor the sexual transmission of hepatitis C?
    P Filippini
    Institute of Infectious Diseases, Second University of Naples, Naples, Italy
    Sex Transm Dis 28:725-9. 2001
    ..There are widely discrepant findings on the sexual transmission of hepatitis C virus (HCV), commonly transmitted by the parenteral route. Coinfection with HCV is common in subjects infected with HIV...
  27. doi request reprint Factors affecting the changes in molecular epidemiology of acute hepatitis B in a Southern Italian area
    N Coppola
    Department of Public Medicine, Section of Infectious Diseases, 2nd University of Naples, Italy
    J Viral Hepat 17:493-500. 2010
    ....
  28. pmc Antibodies to hepatitis A virus in Italian patients with chronic liver disease
    E Sagnelli
    Institute of Infectious Diseases, Second University of Naples, Italy
    Epidemiol Infect 127:341-6. 2001
    ..The data suggest that the number of patients with chronic liver disease without naturally acquired immunity against HAV is substantial in Italy, particularly in the north of the country, and that new vaccination strategies are needed...
  29. ncbi request reprint Virological pattern in plasma, peripheral blood mononuclear cells and liver tissue and clinical outcome in chronic hepatitis B and C virus coinfection
    Nicola Coppola
    Department of Public Medicine, Second University of Naples, Italy
    Antivir Ther 13:307-18. 2008
    ....
  30. ncbi request reprint Clinical expression of 'silent' hepatitis B virus infection in a patient with visceral leishmaniasis
    N Coppola
    Institute of Infectious Diseases, Second University of Naples, Italy
    Infection 29:166-9. 2001
    ..Restoration of the immune system after successful antiprotozoan therapy might have induced cell-mediated necrosis of the HBV-infected hepatocytes and seroconversion to anti-HBs...
  31. ncbi request reprint Virological and clinical aspects of HBV-HCV coinfection in HIV positive patients
    Pietro Filippini
    Department of Public Medicine, Section of Infectious Diseases, Second University of Naples, Naples, Italy
    J Med Virol 79:1679-85. 2007
    ..In anti-HIV positive patients HBV/HCV coinfection is characterized by reciprocal inhibition of viral replication, more evident in HBV expression in plasma and at times by progression to occult HBV infection...
  32. doi request reprint Role of interleukin 28-B in the spontaneous and treatment-related clearance of HCV infection in patients with chronic HBV/HCV dual infection
    N Coppola
    Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Via L Armanni 5, 80133, Naples, Italy
    Eur J Clin Microbiol Infect Dis 33:559-67. 2014
    ....
  33. ncbi request reprint Helicobacter spp. and liver diseases
    Nicola Coppola
    Department of Public Medicine, Section of Infectious Disease, University of Naples, Naples, Italy
    Infez Med 11:201-7. 2003
    ..Our data suggest that Helicobacter species were not involved in the pathogenesis of virus-related HCC, chronic hepatitis or liver carcinoma metastasis...
  34. ncbi request reprint Impact of occult hepatitis B virus infection in HIV patients naive for antiretroviral therapy
    Pietro Filippini
    Department of Public Medicine, Section of Infectious Diseases, Second University of Naples, c o Ospedale Gesù e Maria, Via D Cotugno 1, 80135 Naples, Italy
    AIDS 20:1253-60. 2006
    ..To study the impact of occult hepatitis B virus (HBV) infection in 115 consecutive anti-HIV-positive, hepatitis B surface antigen-negative patients, naive for antiretroviral treatment...
  35. ncbi request reprint Acute hepatitis B and C virus coinfection: a virological and clinical study of 3 cases
    Nicola Coppola
    Division of Infectious Diseases, Azienda Ospedaliera S Sebastiano di Caserta, Caserta
    Clin Infect Dis 36:528-32. 2003
    ..In all 3 cases, HBV infection presented first and quickly resolved. Diagnosis of acute HBV/HCV coinfection requires a long follow-up period with careful observation...
  36. doi request reprint Abdominal fat interacts with PNPLA3 I148M, but not with the APOC3 variant in the pathogenesis of liver steatosis in chronic hepatitis C
    R Zampino
    Internal Medicine and Hepatology, Second University of Naples, Naples, Italy
    J Viral Hepat 20:517-23. 2013
    ..APOC3 polymorphisms had no effect on the development of steatosis and no influence on the PNPLA3 polymorphism. The amount of abdominal fat can increase the association of PNPLA3 p.I148M with liver steatosis...
  37. ncbi request reprint Liver biopsy in chronic hepatitis C: the experience of 15 Italian wards of infectious diseases
    Evangelista Sagnelli
    Department of Public Medicine, Section of Infectious Diseases, Second University of Naples, Naples, Italy
    Infez Med 20:31-6. 2012
    ..After LB the physicians changed their opinion on whether to treat with PEG-INF plus ribavirin in 43 (15.5%) cases. Liver histology allows more accurate diagnosis and enables physicians to make the most appropriate choic...
  38. ncbi request reprint Chronic hepatitis D: a vanishing Disease? An Italian multicenter study
    G B Gaeta
    Istituto di Malattie Infettive, Seconda Universita, Napoli, Italy
    Hepatology 32:824-7. 2000
    ..The results anticipate the almost complete control of HDV infection in the near future...
  39. ncbi request reprint Acute hepatitis with severe cholestasis and prolonged clinical course due to hepatitis A virus Ia and Ib coinfection
    Nicola Coppola
    Department of Public Medicine, Section of Infectious Diseases, Second University of Naples, Naples, Italy
    Clin Infect Dis 44:e73-7. 2007
    ..Acute viral hepatitis due to hepatitis A virus is a self-limited illness that infrequently has a severe clinical course...
  40. doi request reprint Improvement in the aetiological diagnosis of acute hepatitis C: a diagnostic protocol based on the anti-HCV-IgM titre and IgG Avidity Index
    Nicola Coppola
    Department of Public Medicine, Section of Infectious Diseases, 2nd University of Naples, Italy
    J Clin Virol 46:222-9. 2009
    ..The gold standard for the diagnosis of acute hepatitis C (AHC) is seroconversion to anti-HCV/HCV-RNA positivity, an occurrence frequently missed in clinical practice...
  41. ncbi request reprint High level of physical activity preserves the cardioprotective effect of preinfarction angina in elderly patients
    P Abete
    Cattedra di Geriatria, Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita degli Studi di Napoli Federico II, Naples, Italy
    J Am Coll Cardiol 38:1357-65. 2001
    ..The study investigated the effects of physical activity on preinfarction angina, a clinical equivalent of ischemic preconditioning (PC), in adult and elderly patients with acute myocardial infarction (AMI)...
  42. ncbi request reprint Uselessness of liver biopsy in patients with hepatitis C virus chronic infection and persistently normal aminotransferase levels
    Giuseppe Pasquale
    Department of Public Medicine, Section of Infectious Diseases Second University of Naples, Italy
    Infez Med 11:11-7. 2003
    ..Our findings showed that the subjects with a persistently normal serum ALT value had minimal or mild chronic hepatitis, thus demonstrating that a liver biopsy is not indicated for these subjects...
  43. ncbi request reprint Hepatitis viruses and HIV infection in the Naples area
    Pietro Filippini
    Department of Medicine and Public Health, Section of Infectious Diseases, Second University of Naples, Naples, Italy
    Infez Med 11:139-45. 2003
    ..The presence of a more severe liver disease was linked to a multiple hepatitis virus infection, regardless of the degree of immunodeficiency...
  44. doi request reprint Retrospective, observational, multicentre study on an Italian population affected by chronic hepatitis C who failed to clear HCV-RNA after the combined therapy (PEG-IFN and ribavirin): NADIR study
    F Morisco
    Clinical and Experimental Medicine, Gastroenterology Unit, University of Naples Federico II, Naples, Italy
    J Viral Hepat 17:427-34. 2010
    ..Co-morbidities are unable to determine the type of treatment failure and inadequate adherence to therapy mostly affects patients older than 65 years of age...
  45. ncbi request reprint Lipodystrophy and serum lipid abnormalities in HIV-positive sub-Saharan population on ART
    Pietro Filippini
    Department of Public Medicine, Section of Diagnosis and Treatment of AIDS, Second University of Naples, Italy
    J Infect 53:e29-33. 2006
    ..5 vs. 13%, P<0.001). This study seems to indicate that anti-retroviral-induced lipodystrophy and hypertriglyceridemia may be associated to some racial factor...
  46. ncbi request reprint Anti-HCV IgG avidity index in acute hepatitis C
    Nicola Coppola
    Department of Public Medicine, Section of Infectious Diseases, Second University of Naples, Italy
    J Clin Virol 40:110-5. 2007
    ..The diagnosis of acute hepatitis C (AHC) is based on seroconversion to positive anti-HCV, which is usually not clinically possible...
  47. ncbi request reprint Is liver biopsy necessary for hepatitis C virus carriers with persistently normal aminotransferase levels?
    Giuseppe Pasquale
    Eur J Gastroenterol Hepatol 15:831-3. 2003
  48. ncbi request reprint [An attempt to improve classification of HCV-correlated chronic hepatitis]
    Giuseppe Pasquale
    Dipartimento di Malattie Infettive, Seconda Universita degli Studi di Napoli, Italy
    Infez Med 13:16-22. 2005
    ..The Desmet classification of HCV-related chronic hepatitis underestimated the severe forms of HCV-CH, while our classification seems to be suitable also for chronic hepatitis C...
  49. ncbi request reprint Antiretroviral therapy in chronic liver disease: focus on HIV/HCV coinfection--statements of the First Italian Consensus Workshop
    Giampiero Carosi
    Department of Infectious Disease, University of Brescia, Brescia, Italy
    AIDS Rev 7:161-7. 2005
    ....
  50. ncbi request reprint Absence of Helicobacter spp in the liver of patients with primary or metastatic liver cancer
    Nicola Coppola
    Hepatology 36:1300-1. 2002