L Politano

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. ncbi Gentamicin administration in Duchenne patients with premature stop codon. Preliminary results
    L Politano
    Department of Clinical and Experimental Medicine and Surgery, Section of Cardiomyology and Medical Genetics, 2nd University of Naples, Italy
    Acta Myol 22:15-21. 2003
  2. pmc Telethon Network of Genetic Biobanks: a key service for diagnosis and research on rare diseases
    Mirella Filocamo
    UOSD Centro di Diagnostica Genetica e Biochimica delle Malattie Metaboliche, Istituto G, Gaslini, Largo G, Gaslini 5, 16147 Genova, Italy
    Orphanet J Rare Dis 8:129. 2013
  3. pmc On a case of respiratory failure due to diaphragmatic paralysis and dilated cardiomyopathy in a patient with nemaline myopathy
    Antonella Taglia
    Cardiomyology and Medical Genetics, Department of Experimental Medicine, Second University of Naples, Italy
    Acta Myol 31:201-3. 2012
  4. pmc Genetic counseling in Pompe disease
    Antonella Taglia
    Cardiomyology and Medical Genetics, Department of Experimental Medicine and CIRM, Second Naples University, Naples, Italy
    Acta Myol 30:179-81. 2011
  5. pmc Cardiac involvement in patients with spinal muscular atrophies
    Alberto Palladino
    Cardiomyology and Medical Genetics, Department of Experimental Medicine, Second University of Naples, Italy
    Acta Myol 30:175-8. 2011
  6. pmc Improvement of survival in Duchenne Muscular Dystrophy: retrospective analysis of 835 patients
    Luigia Passamano
    Cardiomyology and Medical Genetics, Department of Experimental Medicine, Second University of Naples, Italy
    Acta Myol 31:121-5. 2012
  7. pmc The empowerment of translational research: lessons from laminopathies
    Sara Benedetti
    National Research Council of Italy, Institute of Molecular Genetics, IGM CNR, Unit of Bologna, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Orphanet J Rare Dis 7:37. 2012
  8. pmc Advances in basic and clinical research in laminopathies
    Luisa Politano
    Department of Experimental Medicine, Second University of Naples, Italy
    Acta Myol 32:18-22. 2013
  9. pmc Treatment of dystrophinopathic cardiomyopathy: review of the literature and personal results
    Luisa Politano
    Cardiomyology and Medical Genetics, Department of Experimental Medicine, Second University of Naples, Italy
    Acta Myol 31:24-30. 2012
  10. ncbi ST-segment displacement in Duchenne muscular dystrophy: myocardial necrosis or apoptosis?
    L Politano
    Dipartimento Medico Chirurgico di Internistica Clinica e Sperimentale, Sezione di Cardiomiologia e Genetica Medica, Seconda Universita di Napoli, Piazza Miraglia, 80138 Napoli, Italy
    Acta Myol 22:5-10. 2003

Collaborators

  • V Nigro
  • Gerardo Nigro
  • Giulio Piluso
  • Grzegorz Opolski
  • Nicola Carboni
  • Corrado Angelini
  • Marina Fanin
  • Orlando Paciello
  • Alessandro Pini
  • W D Biggar
  • M Vainzof
  • S Gnudi
  • A Broccolini
  • L Merlini
  • Antonella Taglia
  • Paola D'Ambrosio
  • Alberto Palladino
  • Luigia Passamano
  • Maria Rosaria Cecio
  • Emanuela Viggiano
  • Esther Picillo
  • E Viggiano
  • Mirella Filocamo
  • Sara Benedetti
  • Francesco De Luca
  • Vito Torre
  • Marianna Scutifero
  • E Ammendola
  • Y Rideau
  • B Talim
  • E Picillo
  • Maurizio Moggio
  • Francesca Dagna Bricarelli
  • Alessandra Renieri
  • Lorena Casareto
  • A Cirillo
  • Stefano Goldwurm
  • Marina Mora
  • Barbara Garavaglia
  • Chiara Baldo
  • Giuseppe Merla
  • Renato Pasquali
  • Carmelo Rodolico
  • Iria Neri
  • Elena Biagini
  • Marianna Fontana
  • Giulia Ricci
  • Alessandra Gambineri
  • Marta Columbaro
  • Monica D'Adamo
  • Stefano Squarzoni
  • Gabriele Siciliano
  • Emanuela Scarano
  • Lucia O Morandi
  • Rocco Liguori
  • Laura Mazzanti
  • Eugenio Mercuri
  • Cristina Capanni
  • Pia Bernasconi
  • Giuseppe Boriani
  • Matteo Ziacchi
  • Adele d'Amico
  • Liliana Vercelli
  • Paolo Sbraccia
  • Claudio Rapezzi
  • Stefano Previtali
  • Michela Ortolani
  • Giovanna Lattanzi
  • Antonio Toscano
  • Lisa Pucci
  • Giovanna Cenacchi
  • Tiziana Mongini
  • Enrico Bertini
  • Giuseppe Novelli
  • Nadir M Maraldi
  • Maria Rosaria D'Apice
  • Stefania Petrini
  • L Santangelo
  • R Calabro
  • V Russo
  • C Malaguti

Detail Information

Publications24

  1. ncbi Gentamicin administration in Duchenne patients with premature stop codon. Preliminary results
    L Politano
    Department of Clinical and Experimental Medicine and Surgery, Section of Cardiomyology and Medical Genetics, 2nd University of Naples, Italy
    Acta Myol 22:15-21. 2003
    ..These results suggest that gentamicin is able to recover dystrophin expression in a subset of Duchenne patients with nonsense mutations, raising the possibility of the first pharmacological treatment for muscular dystrophy...
  2. pmc Telethon Network of Genetic Biobanks: a key service for diagnosis and research on rare diseases
    Mirella Filocamo
    UOSD Centro di Diagnostica Genetica e Biochimica delle Malattie Metaboliche, Istituto G, Gaslini, Largo G, Gaslini 5, 16147 Genova, Italy
    Orphanet J Rare Dis 8:129. 2013
    ..This article focuses on some fundamental aspects of networking and demonstrates how the translational research benefits from a sustained infrastructure. ..
  3. pmc On a case of respiratory failure due to diaphragmatic paralysis and dilated cardiomyopathy in a patient with nemaline myopathy
    Antonella Taglia
    Cardiomyology and Medical Genetics, Department of Experimental Medicine, Second University of Naples, Italy
    Acta Myol 31:201-3. 2012
    ..This case highlights the wide spectrum of presenting features of adult-onset nemaline myopathy and the temporary efficacy of non invasive ventilation on respiratory function...
  4. pmc Genetic counseling in Pompe disease
    Antonella Taglia
    Cardiomyology and Medical Genetics, Department of Experimental Medicine and CIRM, Second Naples University, Naples, Italy
    Acta Myol 30:179-81. 2011
    ..The diagnosis could be achieved by biochemical and/or molecular testing. Carrier detection and prenatal diagnosis are available when the molecular defect is known...
  5. pmc Cardiac involvement in patients with spinal muscular atrophies
    Alberto Palladino
    Cardiomyology and Medical Genetics, Department of Experimental Medicine, Second University of Naples, Italy
    Acta Myol 30:175-8. 2011
    ..Data here reported contribute to reassure patients and their clinicians that type II/III SMAs do not present heart dysfunction...
  6. pmc Improvement of survival in Duchenne Muscular Dystrophy: retrospective analysis of 835 patients
    Luigia Passamano
    Cardiomyology and Medical Genetics, Department of Experimental Medicine, Second University of Naples, Italy
    Acta Myol 31:121-5. 2012
    ....
  7. pmc The empowerment of translational research: lessons from laminopathies
    Sara Benedetti
    National Research Council of Italy, Institute of Molecular Genetics, IGM CNR, Unit of Bologna, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Orphanet J Rare Dis 7:37. 2012
    ....
  8. pmc Advances in basic and clinical research in laminopathies
    Luisa Politano
    Department of Experimental Medicine, Second University of Naples, Italy
    Acta Myol 32:18-22. 2013
    ....
  9. pmc Treatment of dystrophinopathic cardiomyopathy: review of the literature and personal results
    Luisa Politano
    Cardiomyology and Medical Genetics, Department of Experimental Medicine, Second University of Naples, Italy
    Acta Myol 31:24-30. 2012
    ..Several drugs have been employed with the aim to contrast the evolution of cardiomyopathy toward stages of severe congestive heart failure. A review of cardiac treatment in DMD and personal experience are reported and discussed...
  10. ncbi ST-segment displacement in Duchenne muscular dystrophy: myocardial necrosis or apoptosis?
    L Politano
    Dipartimento Medico Chirurgico di Internistica Clinica e Sperimentale, Sezione di Cardiomiologia e Genetica Medica, Seconda Universita di Napoli, Piazza Miraglia, 80138 Napoli, Italy
    Acta Myol 22:5-10. 2003
    ..Clinical features of this uncommon pattern are described, with the retrospective evaluation of similar cases from personal records. The differential diagnosis between myocardial necrosis and apoptosis is discussed...
  11. ncbi Evaluation of cardiac and respiratory involvement in sarcoglycanopathies
    L Politano
    Dipartimento di Internistica Clinica e Sperimentale, Sezione di Cardiomiologia e Genetica Medica, Seconda Universita di Napoli, I Policlinico, Piazza Miraglia, 80138, Naples, Italy
    Neuromuscul Disord 11:178-85. 2001
    ..A normal respiratory function was observed in 23.5% of all patients, a mild impairment in 35.4%, a moderate impairment in 29.4%, and a severe impairment in 11.7%...
  12. ncbi Cardiac treatment in neuro-muscular diseases
    G Nigro
    Department of Experimental Medicine, Cardiomyology and Medical Genetics Service, Second University of Naples, Italy
    Acta Myol 25:119-23. 2006
    ..The results show the usefulness of the recent protocols of treatment of cardiac involvement in muscle dystrophy patients...
  13. ncbi Cardiomyopathies: diagnosis of types and stages
    G Nigro
    Department of Experimental Medicine, Cardiomyology and Medical Genetics, Second Naples University, Naples, Italy
    Acta Myol 23:97-102. 2004
    ..In the course of their evolution, cardiomyopathies can shift from a clinical picture to another, consequently requiring frequent examinations of patients in order to adjust their treatment...
  14. ncbi Comparison of X-chromosome inactivation in Duchenne muscle/myocardium-manifesting carriers, non-manifesting carriers and related daughters
    E Viggiano
    Department of Experimental Medicine, Cardiomyology and Medical Genetics, Second University of Naples, Naples, Italy
    Clin Genet 84:265-70. 2013
    ..The results confirm that DMD clinical manifestations in carriers are associated with non-random patterns of X inactivation. ..
  15. pmc Usefulness of heart rate variability as a predictor of sudden cardiac death in muscular dystrophies
    L Politano
    Department of Experimental Medicine, Cardiomyology and Medical Genetics, Second University of Naples, Naples, Italy
    Acta Myol 27:114-22. 2008
    ..Usefulness of heart rate variability as a predictor of sudden cardiac death in muscular dystrophies has been reviewed...
  16. pmc Extensive scanning of the calpain-3 gene broadens the spectrum of LGMD2A phenotypes
    G Piluso
    Dipartimento di Patologia Generale e Centro di Eccellenza per le malattie cardiovascolari, Seconda Universita di Napoli, Naples, Italy
    J Med Genet 42:686-93. 2005
    ..Seventeen autosomal loci have been so far identified and genetic tests are mandatory to distinguish among the forms. Mutations at the calpain 3 locus (CAPN3) cause LGMD type 2A...
  17. pmc Is the value of QT dispersion a valid method to foresee the risk of sudden death? A study in Becker patients
    Ge Nigro
    Electrophysiologic Service of Cardiological Department, Second Naples University, Naples, Italy
    Heart 87:156-7. 2002
  18. ncbi Deflazacort in Duchenne muscular dystrophy: a comparison of two different protocols
    W D Biggar
    Bloorview MacMillan Children s Centre, 150 Kilgour Road, Toronto, Ont M4G 1R8, Canada
    Neuromuscul Disord 14:476-82. 2004
    ..However, the protocol-T seems to be more effective and frequently is associated with asymptomatic cataracts...
  19. pmc Is heart rate variability a valid parameter to predict sudden death in patients with Becker's muscular dystrophy?
    E Ammendola
    Heart 92:1686-7. 2006
  20. ncbi Research against incurability. Treatment of lethal neuromuscular diseases focused on Duchenne Muscular Dystrophy
    Y Rideau
    Duchenne International Institute, Poitiers University, France
    Acta Myol 23:163-78. 2004
  21. ncbi Vertebral compression in Duchenne muscular dystrophy following deflazacort
    B Talim
    Laboratory of Neuromuscular Pathology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Neuromuscul Disord 12:294-5. 2002
  22. ncbi Autosomal recessive limb-girdle muscular dystrophy, LGMD2F, is caused by a mutation in the delta-sarcoglycan gene
    V Nigro
    Istituto di Patologia Generale e Oncologia, Facolta di Medicina, Seconda Universita degli Studi di Napoli, Italy
    Nat Genet 14:195-8. 1996
    ..We now show that a homozygous mutation in the delta SG gene (a single nucleotide deletion that alters its reading frame) is the cause of LGMD2F...
  23. ncbi Novel small mutations along the DMD/BMD gene associated with different phenotypes
    V Nigro
    Istituto di Patologia Generale ed Oncologia, Facolta di Medicina, II Universita di Napoli, Italy
    Hum Mol Genet 3:1907-8. 1994
  24. ncbi Detection of a nonsense mutation in the dystrophin gene by multiple SSCP
    V Nigro
    Istituto di Patologia Generale e Oncologia, I Facoltà di Medicina Università di Napoli, Italy
    Hum Mol Genet 1:517-20. 1992
    ..The patient inherited this mutation from his mother. In addition the analysis revealed 5 polymorphisms useful for internal control...