Giuseppe Paolisso

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. ncbi request reprint Pathophysiology of diabetes in elderly people
    Giuseppe Paolisso
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Italy
    Acta Biomed 81:47-53. 2010
  2. doi request reprint Dipeptidyl peptidase-4 inhibitors in the elderly: more benefits or risks?
    Giuseppe Paolisso
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy
    Adv Ther 29:218-33. 2012
  3. ncbi request reprint The link between insulin resistance and mobility limitation in older persons
    Virginia Boccardi
    Department of Internal Medicine, Surgical, Neurological, Metabolic Disease and Geriatric Medicine Second University of Naples Naples, Italy
    Curr Pharm Des 20:3095-8. 2014
  4. pmc Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-IV inhibition
    Maria Rosaria Rizzo
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Care 35:2076-82. 2012
  5. pmc Mediterranean diet, telomere maintenance and health status among elderly
    Virginia Boccardi
    Department of Internal Medicine, Surgical, Neurological Metabolic Disease and Geriatric Medicine, Second University of Naples, Naples, Italy
    PLoS ONE 8:e62781. 2013
  6. pmc Effects of PPARs agonists on cardiac metabolism in littermate and cardiomyocyte-specific PPAR-γ-knockout (CM-PGKO) mice
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy
    PLoS ONE 7:e35999. 2012
  7. pmc Adiposity predicts cognitive decline in older persons with diabetes: a 2-year follow-up
    Angela Marie Abbatecola
    Scientific Direction, Italian National Research Center on Aging, Ancona, Italy
    PLoS ONE 5:e10333. 2010
  8. pmc Effects of the diabetes linked TCF7L2 polymorphism in a representative older population
    David Melzer
    Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter, EX2 5DW, UK
    BMC Med 4:34. 2006
  9. ncbi request reprint Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control
    Massimiliano Bonafe
    Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
    J Clin Endocrinol Metab 88:3299-304. 2003
  10. doi request reprint Effects of vildagliptin twice daily vs. sitagliptin once daily on 24-hour acute glucose fluctuations
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases Second University of Naples, Naples, Italy
    J Diabetes Complications 24:79-83. 2010

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Pathophysiology of diabetes in elderly people
    Giuseppe Paolisso
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Italy
    Acta Biomed 81:47-53. 2010
    ..The present review discusses the European Diabetes Working Party guidelines for type 2 diabetes in older persons with and without frailty and their importance on preventing or at least slowing down diverse aspects of disability...
  2. doi request reprint Dipeptidyl peptidase-4 inhibitors in the elderly: more benefits or risks?
    Giuseppe Paolisso
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy
    Adv Ther 29:218-33. 2012
    ..Due to their characteristics, DPP-4 inhibitors seem to be particularly interesting as potential agents for the treatment of older patients with T2DM...
  3. ncbi request reprint The link between insulin resistance and mobility limitation in older persons
    Virginia Boccardi
    Department of Internal Medicine, Surgical, Neurological, Metabolic Disease and Geriatric Medicine Second University of Naples Naples, Italy
    Curr Pharm Des 20:3095-8. 2014
    ....
  4. pmc Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-IV inhibition
    Maria Rosaria Rizzo
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Care 35:2076-82. 2012
    ....
  5. pmc Mediterranean diet, telomere maintenance and health status among elderly
    Virginia Boccardi
    Department of Internal Medicine, Surgical, Neurological Metabolic Disease and Geriatric Medicine, Second University of Naples, Naples, Italy
    PLoS ONE 8:e62781. 2013
    ..048). These results support a novel role of MD in promoting health-span suggesting that telomere maintenance, rather than LTL variability is the major determinant of healthy status among elderly...
  6. pmc Effects of PPARs agonists on cardiac metabolism in littermate and cardiomyocyte-specific PPAR-γ-knockout (CM-PGKO) mice
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy
    PLoS ONE 7:e35999. 2012
    ..Nevertheless a direct non-PPARγ mediated mechanism of PPARγ agonist could not be ruled out...
  7. pmc Adiposity predicts cognitive decline in older persons with diabetes: a 2-year follow-up
    Angela Marie Abbatecola
    Scientific Direction, Italian National Research Center on Aging, Ancona, Italy
    PLoS ONE 5:e10333. 2010
    ..We tested if adiposity parameters and body fat distribution could predict cognitive decline in older persons with DM vs. normal glucose tolerance (NGT)...
  8. pmc Effects of the diabetes linked TCF7L2 polymorphism in a representative older population
    David Melzer
    Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter, EX2 5DW, UK
    BMC Med 4:34. 2006
    ..We aimed to estimate associations of the marker rs7903146 (C/T) polymorphism with fasting glucose, lipids, diabetes prevalence and complications in an older general population...
  9. ncbi request reprint Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control
    Massimiliano Bonafe
    Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
    J Clin Endocrinol Metab 88:3299-304. 2003
    ....
  10. doi request reprint Effects of vildagliptin twice daily vs. sitagliptin once daily on 24-hour acute glucose fluctuations
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases Second University of Naples, Naples, Italy
    J Diabetes Complications 24:79-83. 2010
    ..Since MAGE is associated with an activation of oxidative stress, our data suggest that dipeptidyl peptidase IV inhibition therapy should target not only reducing HbA(1c) but also flattening acute glucose fluctuations over a daily period...
  11. ncbi request reprint Oral amino acid administration decreases oxidative stress and improves brachial reactivity in elderly individuals
    Daniela Manzella
    Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Naples, Italy
    Am J Hypertens 18:858-63. 2005
    ..Endothelial dysfunction is recognized as a key early event in atherogenesis. In the present study, we evaluated the possible beneficial effect of amino acid administration on endothelial regulation in elderly subjects...
  12. doi request reprint Proteasome activity as a target of hormone replacement therapy-dependent plaque stabilization in postmenopausal women
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Second University Naples, Naples, Italy
    Hypertension 51:1135-41. 2008
    ..This effect, in turn, might contribute to plaque stabilization by inhibiting the activation of nuclear factor kappaB-dependent inflammation, responsible for plaque rupture...
  13. ncbi request reprint Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly
    Angela M Abbatecola
    Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Naples, Italy
    J Am Geriatr Soc 52:399-404. 2004
    ..To evaluate the potential association between different inflammatory markers and insulin resistance (IR), as well as insulin-resistance syndrome (IRS) in a large, population-based study of older, nondiabetic persons...
  14. pmc Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    J Lipid Res 50:2314-23. 2009
    ..001). SREBP-1c may contribute to heart dysfunction by promoting lipid accumulation within myocytes in MS patients with AS; SREBP-1c may do it by increasing the levels of PPARgamma protein...
  15. doi request reprint The -8 UTR C/G polymorphism of PSMA6 gene is associated with susceptibility to myocardial infarction in type 2 diabetic patients
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Piazza Miraglia 2, 80138 Naples, Italy
    Atherosclerosis 201:117-23. 2008
    ....
  16. ncbi request reprint Blood pressure and cardiac autonomic nervous system in obese type 2 diabetic patients: effect of metformin administration
    Daniela Manzella
    Department of Geriatric Medicine and Metabolic Diseases, Internal Medicine IV, Second University of Naples, Piazza Miraglia 2, I 10838 Naples, Italy
    Am J Hypertens 17:223-7. 2004
    ..Metformin improves insulin action and lower plasma FFA concentrations. We investigate the possible effect of metformin on arterial blood pressure (BP) and cardiac sympathetic nervous system...
  17. ncbi request reprint The ubiquitin-proteasome system contributes to the inflammatory injury in ischemic diabetic myocardium: the role of glycemic control
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Cardiovasc Pathol 18:332-45. 2009
    ..Finally, this study aimed to elucidate whether an intervention on UPS with bortezomib, an inhibitor of UPS, may counteract the extensive myocardial infarction and increased inflammatory reaction into the hyperglycemic myocardium...
  18. ncbi request reprint Evidence for anti-inflammatory effects of combined administration of vitamin E and C in older persons with impaired fasting glucose: impact on insulin action
    Maria Rosaria Rizzo
    Second University of Naples, Department of Geriatric Medicine and Metabolic Diseases, Naples, Italy
    J Am Coll Nutr 27:505-11. 2008
    ..To investigate combined effect of Vitamin E and C in elderly with Impaired Fasting Glucose (IFG) on insulin action and substrate oxidation...
  19. ncbi request reprint Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, VI Divisione di Medicina Interna, II University of Naples, Piazza Miraglia 2, I 80138, Italy
    Exp Gerontol 39:1095-100. 2004
    ..Such an effect is probably due to the effect of Pro/Ala polymorphism on body composition and appears to be gender specific...
  20. ncbi request reprint Glucose regulation and oxidative stress in healthy centenarians
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, IV Divisione di Medicina Interna, Piazza Miraglia 2, I 80138 Napoli, Italy
    Exp Gerontol 38:137-43. 2003
    ..It is likely that a specific genetic background might play a role. However, the insulin gene does not seem to be involved for explaining such age-related differences...
  21. ncbi request reprint Morning blood pressure surge as a destabilizing factor of atherosclerotic plaque: role of ubiquitin-proteasome activity
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples, Italy
    Hypertension 49:784-91. 2007
    ..These data suggest a potential interplay between morning blood pressure surge and ubiquitin-proteasome activity in atherosclerosis pathophysiology...
  22. ncbi request reprint Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians
    Claudio Franceschi
    Italian National Research Center on Aging, Ancona, Italy
    Mech Ageing Dev 126:351-61. 2005
    ..We extensively screened Alu-rich genomic sites and found a new genomic region associated with longevity...
  23. pmc Dipeptidyl peptidase 4 inhibition may facilitate healing of chronic foot ulcers in patients with type 2 diabetes
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, 80138 Naples, Italy
    Exp Diabetes Res 2012:892706. 2012
    ..Although elucidation of the pathophysiologic importance of these aspects awaits further confirmations, the present study evidences an additional aspect of how DPP-4 inhibition might contribute to improved ulcer outcome...
  24. doi request reprint Tight glycemic control may increase regenerative potential of myocardium during acute infarction
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Piazza Miraglia, 2, 80138 Naples, Italy
    J Clin Endocrinol Metab 97:933-42. 2012
    ..We analyzed the effects of tight glycemic control on regenerative potential of myocardium during acute myocardial infarction...
  25. doi request reprint The IRS2 Gly1057Asp variant is associated with human longevity
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Piazza Miraglia 2, 80138, Naples, Italy
    J Gerontol A Biol Sci Med Sci 65:282-6. 2010
    ..The aim of our study was to evaluate whether a common polymorphism (Gly1057Asp) in human IRS2 gene is associated with human longevity...
  26. doi request reprint Role of subcutaneous abdominal fat on cardiac function and proinflammatory cytokines in premenopausal obese women
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Ann Plast Surg 63:490-5. 2009
    ..Abdominoplasty may represent a safe method for ameliorating cardiac function in obese women...
  27. doi request reprint Tight glycemic control reduces heart inflammation and remodeling during acute myocardial infarction in hyperglycemic patients
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    J Am Coll Cardiol 53:1425-36. 2009
    ..We analyzed the molecular mechanisms evoked by tight glycemic control during post-infarction remodeling in human hearts...
  28. pmc Bariatric surgery reduces oxidative stress by blunting 24-h acute glucose fluctuations in type 2 diabetic obese patients
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Care 33:287-9. 2010
    ..We evaluated the efficacy of malabsorptive bariatric surgery on daily blood glucose fluctuations and oxidative stress in type 2 diabetic obese patients...
  29. pmc A/ASP/VAL allele combination of IGF1R, IRS2, and UCP2 genes is associated with better metabolic profile, preserved energy expenditure parameters, and low mortality rate in longevity
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Piazza Miraglia 2, 80138, Naples, Italy
    Age (Dordr) 34:235-45. 2012
    ..Such an effect is probably due to the combined effect of IGF1R, IRS2, and UCP2 genes on energy metabolism and on the age-related metabolic remodeling capacity...
  30. ncbi request reprint Endothelial function and menopause: effects of raloxifene administration
    Nicola Colacurci
    Department of Gynecology and Obstetrics, Second University of Naples, I 80138 Naples, Italy
    J Clin Endocrinol Metab 88:2135-40. 2003
    ..In conclusion, our results demonstrate that raloxifene administration is associated with a positive modulation of endothelial-dependent vasodilatation likely due to a reduction of risk factors for endothelial damage...
  31. pmc Potential role of TCF7L2 gene variants on cardiac sympathetic/parasympathetic activity
    Virginia Boccardi
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy
    Eur J Hum Genet 18:1333-8. 2010
    ..Moreover, such effect is independent of GLP-1 and insulin plasma concentrations suggesting a potential role of such gene variants in increasing cardiovascular risk through enhanced sympathetic nervous system activity...
  32. ncbi request reprint The PON1192RR genotype is associated with a higher prevalence of arterial hypertension
    Maurizio Marra
    Diabetology Unit, INRCA, Ancona, Italy
    J Hypertens 24:1293-8. 2006
    ..To investigate whether genetic polymorphism of paraoxonase (PON1192), an enzyme which protects low density lipoprotein from oxidation, is related to the prevalence of arterial hypertension...
  33. ncbi request reprint Is the aging heart similar to the diabetic heart? Evaluation of LV function of the aging heart with Tissue Doppler Imaging
    Fulvio Cacciapuoti
    Echocardiography, Department of Geriatrics and Metabolic Disease, II University of Naples, Naples, Italy
    Aging Clin Exp Res 21:22-6. 2009
    ..Left ventricular (LV) function in the healthy aging heart is modified by biochemical changes with advancing age. We employed for the first time Tissue Doppler Imaging (TDI), to identify which phase of the cardiac cycle is involved...
  34. ncbi request reprint Residual C-peptide secretion and endothelial function in patients with Type II diabetes
    Daniela Manzella
    Department of Geriatric Medicine and Metabolic Diseases, IV Internal Medicine, Piazza Miraglia 2, I 80138 Napoli, Italy
    Clin Sci (Lond) 105:113-8. 2003
    ..In conclusion, our study demonstrated that patients with Type II diabetes with good residual C-peptide secretion are better protected from endothelial dysfunction that those with poor C-peptide secretion...
  35. ncbi request reprint Effects of ubiquitin-proteasome system deregulation on the vascular senescence and atherosclerosis process in elderly patients
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    J Gerontol A Biol Sci Med Sci 63:200-3. 2008
    ..The role of the ubiquitin-proteasome system in the vascular senescence and atherosclerotic progression of elderly patients is unclear. We evaluated ubiquitin-proteasome activity in carotid plaques of asymptomatic elderly and adult patients...
  36. pmc Association of genetic variation in adaptor protein APPL1/APPL2 loci with non-alcoholic fatty liver disease
    Michelangela Barbieri
    Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Second University of Naples, Naples, Italy
    PLoS ONE 8:e71391. 2013
    ..88; 95% CI 1.582-9.531; p<0.001). In conclusion, C-APPL1/A-APPL2 allele combination is associated with NAFLD occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin cytoprotective effect on liver. ..
  37. pmc Rosiglitazone and cognitive stability in older individuals with type 2 diabetes and mild cognitive impairment
    Angela M Abbatecola
    Italian National Research Center on Aging, Ancona, Italy
    Diabetes Care 33:1706-11. 2010
    ..We aimed to determine whether an improvement in insulin resistance could explain cognitive performance variations over 36 weeks in older individuals with mild cognitive impairment (MCI) and type 2 diabetes...
  38. ncbi request reprint Insulin resistance and executive dysfunction in older persons
    Angela M Abbatecola
    Department Geriatric Medicine and Metabolic Diseases, II University of Naples, Naples, Italy
    J Am Geriatr Soc 52:1713-8. 2004
    ..To evaluate the association between insulin resistance (IR) and executive dysfunction in a large, population-based study of older persons without diabetes mellitus (DM) or dementia...
  39. ncbi request reprint Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Italy
    Am J Physiol Endocrinol Metab 284:E481-7. 2003
    ..This mechanism may explain why IL-6 is a strong risk factor for disability...
  40. doi request reprint Brief episodes of silent atrial fibrillation predict clinical vascular brain disease in type 2 diabetic patients
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Piazza Miraglia 2, Naples, Italy
    J Am Coll Cardiol 62:525-30. 2013
    ....
  41. doi request reprint Shear stress as target to reduce atherosclerosis progression in hypertensive patients
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples, Italy
    Am J Hypertens 21:729. 2008
  42. ncbi request reprint Changing the metabolic profile by large-volume liposuction: a clinical study conducted with 123 obese women
    Francesco D'Andrea
    Department of Plastic and Reconstructive Surgery, Second University of Naples, VIA L Decrecchio 4, 80100 Naples, Italy
    Aesthetic Plast Surg 29:472-8; discussion 479-80, 481. 2005
    ..However, these findings, confirm other preliminary data published previously, and could change the actual role of LVL in the multidisciplinary treatment of obesity...
  43. ncbi request reprint Effects of soy isoflavones on endothelial function in healthy postmenopausal women
    Nicola Colacurci
    Department of Gynecology and Obstetrics, IV Internal Medicine, School of Medicine, Second University of Naples, Naples, Italy
    Menopause 12:299-307. 2005
    ..To evaluate the effects of soy isoflavone administration on endothelial function in healthy postmenopausal women...
  44. doi request reprint Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Piazza Miraglia 2, 80138 Naples, Italy
    Mech Ageing Dev 130:771-6. 2009
    ..Our findings suggest that both circulating IGF-1 and LTL are indices of healthy aging in humans. Further research will be necessary to establish whether LTL will ultimately be used in clinical settings as an index of healthy aging...
  45. doi request reprint A multicentre, randomized study of telmisartan versus carvedilol for prevention of atrial fibrillation recurrence in hypertensive patients
    Domenico Galzerano
    Division of Cardiology, San Gennaro Hospital, Naples, Italy
    J Renin Angiotensin Aldosterone Syst 13:496-503. 2012
    ..Atrial remodelling, leading to atrial fibrillation (AF), is mediated by the renin-angiotensin-aldosterone system...
  46. ncbi request reprint Long term effects of low protein diet on depressive symptoms and quality of life in elderly Type 2 diabetic patients
    Tiziana Ciarambino
    Department of Gerontology, Geriatrics adn Metabolic Disease, Second University of Naples, Naples
    Clin Nephrol 78:122-8. 2012
    ..The long term effects of a low protein diet (LPD) on depressive symptoms and the quality of life in elderly Type 2 diabetic are unclear...
  47. pmc Relationships between daily acute glucose fluctuations and cognitive performance among aged type 2 diabetic patients
    Maria Rosaria Rizzo
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Care 33:2169-74. 2010
    ....
  48. ncbi request reprint Meal modulation of circulating interleukin 18 and adiponectin concentrations in healthy subjects and in patients with type 2 diabetes mellitus
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Piazza L Miraglia, 80138 Naples, Italy
    Am J Clin Nutr 78:1135-40. 2003
    ..A single high-fat meal induces endothelial activation, which is associated with increased serum concentrations of inflammatory cytokines...
  49. ncbi request reprint Arterial stiffness and cognition in elderly persons with impaired glucose tolerance and microalbuminuria
    Angela M Abbatecola
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Italy, Piazza Miraglia 2, I 80138 Naples, Italy
    J Gerontol A Biol Sci Med Sci 63:991-6. 2008
    ....
  50. ncbi request reprint Circulating microRNA changes in heart failure patients treated with cardiac resynchronization therapy: responders vs. non-responders
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Eur J Heart Fail 15:1277-88. 2013
    ..We studied whether LV reverse remodelling after CRT was associated with changes of circulating miRNAs in patients with heart failure (HF) and dyssynchrony...
  51. ncbi request reprint Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians
    Massimiliano Bonafe
    Department of Experimental Pathology, Bologna University, Bologna, Italy
    Eur J Hum Genet 10:292-6. 2002
    ..In conclusion, we propose that genetic variability at PON1 locus affects survival at extreme advanced age...
  52. doi request reprint Diabetes care targets in older persons
    Angela M Abbatecola
    Italian National Research Center on Aging, Ancona, Italy
    Diabetes Res Clin Pract 86:S35-40. 2009
    ..The present review discusses the European Diabetes Working Party guidelines for type 2 diabetes in older persons with and without frailty and their importance on preventing or at least slowing down diverse aspects of disability...
  53. ncbi request reprint Is chronic inflammation a determinant of blood pressure in the elderly?
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Naples, Italy
    Am J Hypertens 16:537-43. 2003
    ..We investigated the role of chronic inflammation in the modulation of BP independently of other traditional cardiovascular risk factors and atherosclerotic lesions...
  54. doi request reprint Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice
    Michele D'Amico
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Naples, Italy
    Exp Gerontol 45:202-7. 2010
    ..The long-term inhibition of the endogenous DPP-4 enzymes with sitagliptin can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD...
  55. ncbi request reprint Raloxifene slows down the progression of intima-media thickness in postmenopausal women
    Nicola Colacurci
    Department of Obstetrics, Gynecology, and Neonatology, School of Medicine, Second University of Naples, Naples, Italy
    Menopause 14:879-84. 2007
    ..To investigate the effect of raloxifene on atherosclerosis progression in healthy postmenopausal women...
  56. ncbi request reprint Insulin resistance is an independent risk factor for atherosclerosis in rheumatoid arthritis
    Giovanni La Montagna
    Department of Clinical and Experimental Medicine and Surgery Rheumatology Unit, Second University of Naples, Via Pansini, 5 80131 Naples, Italy
    Diab Vasc Dis Res 4:130-5. 2007
    ..This relationship may be driven primarily by exposure to steroid therapy...
  57. doi request reprint Antidiabetic oral treatment in older people: does frailty matter?
    Angela Marie Abbatecola
    Italian National Research Centre on Aging INRCA, Ancona, Italy
    Drugs Aging 26:53-62. 2009
    ....
  58. ncbi request reprint Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals
    Francesco Nappo
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    J Am Coll Cardiol 39:1145-50. 2002
    ..To compare the effect of a high-fat meal and a high-carbohydrate meal (pizza), with and without antioxidant vitamins, on endothelial activation in healthy subjects and in patients with type 2 diabetes mellitus...
  59. doi request reprint A new pleiotropic effect of statins in elderly: modulation of telomerase activity
    Virginia Boccardi
    Department of Internal Medicine, Surgical, Neurological, Metabolic Disease and Geriatric Medicine, Second University of Naples, P zza Miraglia 2, 80138 Naples, Italy
    FASEB J 27:3879-85. 2013
    ..0001). In summary, statins, modulating telomerase activity, affect telomere erosion along with aging...
  60. doi request reprint Peri-procedural tight glycemic control during early percutaneous coronary intervention is associated with a lower rate of in-stent restenosis in patients with acute ST-elevation myocardial infarction
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, 80138 Naples, Italy
    J Clin Endocrinol Metab 97:2862-71. 2012
    ..We examined the effects of peri-procedural intensive glycemic control (IGC) during early percutaneous coronary intervention (PCI) on restenosis rate in hyperglycemic patients with ST-segment elevation myocardial infarction (STEMI)...
  61. pmc Plasma polyunsaturated fatty acids and age-related physical performance decline
    Angela M Abbatecola
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy
    Rejuvenation Res 12:25-32. 2009
    ..A higher n-6/n-3 ratio was associated with higher risk of developing poor physical performance and slower walking speed...
  62. ncbi request reprint Elevated plasma activator inhibitor 1 is not related to insulin resistance and to gene polymorphism in healthy centenarians
    Maria Rosaria Rizzo
    Department of Geriatric Medicine and Metabolic Diseases, IV Divisione di Medicina Interna, Second University of Naples, Piazza Miraglia, 2, 80138 Naples, Italy
    Atherosclerosis 160:385-90. 2002
    ..Frequency of PAI-1 genotype does not provide an explanation for such differences between aged subjects and centenarians...
  63. ncbi request reprint Increased serum osteoprotegerin values in long-lived subjects: different effects of inflammation and bone metabolism
    Gherardo Mazziotti
    Chair of Endocrinology, Department of Clinical and Experimental Medicine F Magrassi and A Lanzara, Second University of Naples, Italy
    Eur J Endocrinol 154:373-7. 2006
    ..To evaluate serum osteoprotegerin (OPG) concentrations in relation to age-dependent changes in serum markers of bone metabolism and systemic inflammation...
  64. ncbi request reprint Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, University of Naples, 80138 Naples, Italy
    Am J Physiol Endocrinol Metab 285:E1064-71. 2003
    ....
  65. pmc The possible role of the ubiquitin proteasome system in the development of atherosclerosis in diabetes
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Cardiovasc Diabetol 6:35. 2007
    ....
  66. ncbi request reprint LL-paraoxonase genotype is associated with a more severe degree of homeostasis model assessment IR in healthy subjects
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, I 80138 Naples, Italy
    J Clin Endocrinol Metab 87:222-5. 2002
    ..001). In conclusion, the presence of LL PON genotype is associated with a more severe degree of IR. Thus, IR might be the possible missing link between Met-Leu 54 PON polymorphism and the increased cardiovascular risk...
  67. ncbi request reprint Clinical and biochemical evaluation changes over aging
    Angela Abbatecola
    Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Naples, Italy
    Cancer Treat Res 124:135-62. 2005
  68. ncbi request reprint FFAs and QT intervals in obese women with visceral adiposity: effects of sustained weight loss over 1 year
    Grazia Maria Corbi
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples 80138, Italy
    J Clin Endocrinol Metab 87:2080-3. 2002
    ....
  69. doi request reprint Use of a non-specific immunomodulation therapy as a therapeutic vasculogenesis strategy in no-option critical limb ischemia patients
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Piazza Miraglia, 2 80138 Napoli, Italy
    Atherosclerosis 208:473-9. 2010
    ..We tested the hypothesis that administration of an oxygen/ozone mixture (IMT) might counteract this pathophysiological mechanism and enhance limb tissue perfusion in patients with critical limb ischemia (CLI)...
  70. ncbi request reprint Metabolic journey to healthy longevity
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Napoli, Italy
    Horm Res 71:24-7. 2009
    ....
  71. ncbi request reprint Positive association between circulating free insulin-like growth factor-1 levels and coronary flow reserve in arterial systemic hypertension
    Maurizio Galderisi
    Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    Am J Hypertens 15:766-72. 2002
    ..Also, insulin-like growth factor-1 (IGF-1) may be associated with the magnitude of CFR in relation to its modulating action on cardiac and endothelial function...
  72. ncbi request reprint Effect of tibolone administration on heart rate variability and free fatty acid levels in postmenopausal women
    Daniela Manzella
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy
    Fertil Steril 78:1005-9. 2002
    ..To evaluate the effects of tibolone on heart rate variability and plasma free fatty acid levels in postmenopausal women...
  73. ncbi request reprint Relationship between autonomic cardiac activity, beta-cell function, anthropometrics and metabolic indices in type II diabetics
    Daniela Manzella
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 57:259-64. 2002
    ..Thus, we investigated the effect of residual pancreatic C-peptide secretion on the cardiac autonomic nervous system in well- and poorly controlled type II diabetic patients...
  74. ncbi request reprint Cardiac autonomic activity and Type II diabetes mellitus
    Daniela Manzella
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Piazza Miraglia 2, I 80138, Naples, Italy
    Clin Sci (Lond) 108:93-9. 2005
    ..Nevertheless, spectral analysis of heart rate variability seems to remain the primary technique in evaluating CAN, due to its low cost, easy use and good intra-individual reproducibility...
  75. doi request reprint Effects of a 6-days-a-week low protein diet regimen on depressive symptoms in young-old type 2 diabetic patients
    Tiziana Ciarambino
    Department of Gerontology, Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Nutrition 27:46-9. 2011
    ..In addition, depression is a common psychopathological condition among renal failure patients and most of these patients follow a low protein diet regimen (LPD). However, the effects of LPD on depressive symptoms are unclear...
  76. doi request reprint Innate immune activity in plaque of patients with untreated and L-thyroxine-treated subclinical hypothyroidism
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Seconda Università Napoli, 80138 Napoli, Italy
    J Clin Endocrinol Metab 96:1015-20. 2011
    ..A strong association between subclinical hypothyroidism (SCH) and atherosclerotic diseases, independent of the traditional risk factors, was noted...
  77. ncbi request reprint New approaches to treating type 2 diabetes mellitus in the elderly: role of incretin therapies
    Angela M Abbatecola
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy
    Drugs Aging 25:913-25. 2008
    ....
  78. ncbi request reprint Three-dimensional echocardiographic and magnetic resonance assessment of the effect of telmisartan compared with carvedilol on left ventricular mass a multicenter, randomized, longitudinal study
    Domenico Galzerano
    Department of Cardiology, San Gennaro Hospital, Naples, Italy
    Am J Hypertens 18:1563-9. 2005
    ....
  79. ncbi request reprint Increased activity of the ubiquitin-proteasome system in patients with symptomatic carotid disease is associated with enhanced inflammation and may destabilize the atherosclerotic plaque: effects of rosiglitazone treatment
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Section of Pathology, Second University of Naples, Naples, Italy
    J Am Coll Cardiol 47:2444-55. 2006
    ..We evaluated ubiquitin-proteasome activity in carotid plaques of asymptomatic and symptomatic patients and the effect of rosiglitazone, a peroxisome proliferator-activated receptor-gamma activator, in symptomatic plaques...
  80. ncbi request reprint Leptin affects adenylate cyclase activity in H9c2 cardiac cell line: effects of short- and long-term exposure
    Gennaro Illiano
    Department of Biochemistry, F Cedrangolo, Second University of Naples, Italy
    Am J Hypertens 15:638-43. 2002
    ....
  81. ncbi request reprint Screening of depressive symptoms in young-old hemodialysis patients: relationship between Beck Depression Inventory and 15-item Geriatric Depression Scale
    Mauro Giordano
    Department of Gerontology, Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Nephron Clin Pract 106:c187-92. 2007
    ....
  82. ncbi request reprint Insulin-induced changes in beta-adrenergic response: an experimental study in the isolated rat papillary muscle
    Nicola Ferrara
    Department of Health Sciences, University of Molise, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Campoli, Via dei Bagni Vecchi, 82037 Telese Terme, Italy
    Am J Hypertens 18:348-53. 2005
    ..The aim was to investigate the ability of insulin to modulate the response to beta-adrenergic action on myocardial contractility, assessed as percentage changes of developed tension, in isolated rat papillary muscle...
  83. ncbi request reprint Diabetes, ubiquitin proteasome system and atherosclerotic plaque rupture
    Raffaele Marfella
    Circ Res 100:e84-5. 2007
  84. ncbi request reprint Cytokine milieu tends toward inflammation in type 2 diabetes
    Katherine Esposito
    Diabetes Care 26:1647. 2003
  85. pmc Association between hormones and metabolic syndrome in older Italian men
    Marcello Maggio
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 54:1832-8. 2006
    ....
  86. ncbi request reprint Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X
    Mario Barbagallo
    Institute of Internal Medicine and Geriatrics, University of Palermo, Via F Scaduto 6 C, Palermo, Italy
    Mol Aspects Med 24:39-52. 2003
    ..We further suggest that a reduced intracellular Mg concentration might be the missing link helping to explain the epidemiological association between NIDDM and hypertension...
  87. pmc Insulin resistance and cognitive decline may be common soil for frailty syndrome
    Angela Marie Abbatecola
    Arch Intern Med 167:2145-6. 2007
  88. ncbi request reprint Alpha1-antitrypsin heterozygosity plays a positive role in attainment of longevity
    Florinda Listi
    Dipartimento di Biopatologia e Metodologie Biomediche, Gruppo di Studio sull Immunosenescenza, Corso Tukory 211, Palermo 90134, Italy
    Biogerontology 8:139-45. 2007
    ..Thus, our data show a positive role of MZ heterozygosity in attainment of successful ageing linked to the positive effects of this genotype versus the cardiovascular ischemic diseases...
  89. pmc Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study
    Marcello Maggio
    National Institute on Aging, NIH, NIA ASTRA Unit at Harbor Hospital, 3001 S Hanover St, Baltimore, MD 21225, USA
    Am J Physiol Endocrinol Metab 292:E353-8. 2007
    ..Further studies are needed to support the notion that raising SHBG is a potential therapeutic target for prevention and treatment of MetS...
  90. pmc Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Rd, Exeter, EX1 2LU, UK
    Diabetes 57:1419-26. 2008
    ..Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides. We aimed to test whether FTO genotype is associated with variation in these metabolic traits...
  91. doi request reprint Insulin therapy and lipid overload in type 2 diabetes
    Raffaele Marfella
    JAMA 300:789; author reply 790. 2008
  92. ncbi request reprint Repaglinide administration improves brachial reactivity in type 2 diabetic patients
    Daniela Manzella
    Department of Geriatric Medicine and Metabolic Diseases VI, Internal Medicine, Piazza Miraglia 2 I 80138, Napoli, Italy
    Diabetes Care 28:366-71. 2005
    ..Thus, we investigated the possible effect of short-acting (repaglinide) and long-acting (glibenclamide) insulin secretagogues on endothelial function in type 2 diabetic patients...
  93. ncbi request reprint Is there a relationship between insulin resistance and frailty syndrome?
    Angela Marie Abbatecola
    Department of Geriatric Medicine and Metabolic Diseases II, University of Naples, Italy
    Curr Pharm Des 14:405-10. 2008
    ..In particular, we will address the issue that IR may also be considered a pivotal biological component of some clinical aspects of the frailty syndrome in aging individuals...
  94. ncbi request reprint Consensus Document on substitution therapy with testosterone in hypoandrogenic elderly men
    Giorgio Valenti
    Dipartimento di Medicina Interna e Scienze Biomediche, University of Parma, Italy
    Aging Clin Exp Res 14:439-64. 2002
  95. ncbi request reprint Evidence for reduction of pro-atherosclerotic properties in platelets from healthy centenarians
    Rosa Anna Rabini
    Department of Diabetology Research, Italian National Research Center on Aging, Ancona, Italy
    Exp Gerontol 38:367-71. 2003
    ....
  96. pmc High interleukin-6 plasma levels are associated with low HDL-C levels in community-dwelling older adults: the InChianti study
    Giovanni Zuliani
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Geriatrics, University di Ferrara, Ferrara, Italy
    Atherosclerosis 192:384-90. 2007
    ..Clinical studies have demonstrated that cytokines might affect both concentration and composition of plasma lipoproteins, including HDLs...
  97. ncbi request reprint Correspondence between the International Diabetes Federation criteria for metabolic syndrome and insulin resistance in a cohort of Italian nondiabetic Caucasians: the GISIR database
    Giorgio Sesti
    Diabetes Care 30:e33. 2007
  98. ncbi request reprint Circulating leptin correlates with left ventricular mass in morbid (grade III) obesity before and after weight loss induced by bariatric surgery: a potential role for leptin in mediating human left ventricular hypertrophy
    Lucia Perego
    Divisione di Medicina Interna, Istituto Scientifico San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Clin Endocrinol Metab 90:4087-93. 2005
    ..Obesity is frequently associated with left ventricular hypertrophy, even when uncomplicated by hypertension or diabetes mellitus. Left ventricular hypertrophy is an important risk factor for congestive heart failure...
  99. ncbi request reprint Insulin resistance in cognitive impairment: the InCHIANTI study
    Cristina Geroldi
    Laboratory of Epidemiology and Neuroimaging, Istituto de Ricovero e Cura a Carattere Scientifico San Giovanni de Dio Fatebenefratelli, Brescia, Italy
    Arch Neurol 62:1067-72. 2005
    ..To test the association between cognitive impairment, with and without subcortical features, and insulin resistance in an elderly community-dwelling population...
  100. ncbi request reprint Consensus Document on substitution therapy with DHEA in the elderly
    Giorgio Valenti
    Dipartimento di Medicina Interna e Scienze Biomediche, Sezione Geriatria, Universita degli Studi di Parma, Via Gramsci 14, 43100 Parma, Italy
    Aging Clin Exp Res 18:277-300. 2006