Claudio Napoli

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. doi Maternal-foetal epigenetic interactions in the beginning of cardiovascular damage
    Claudio Napoli
    Department of General Pathology, Division of Clinical Pathology and Excellence Research Centre on Cardiovascular Disease, U O C Division of Immunohematology and Transplantation CRT, 1st School of Medicine, Complesso S Andrea delle Dame, Second University of Naples, 80138 Naples, Italy
    Cardiovasc Res 92:367-74. 2011
  2. doi Recent advances in proteomic technologies applied to cardiovascular disease
    Claudio Napoli
    Department of General Pathology, Excellence Research Centre on Cardiovascular Disease, U O C Immunohematology, Transfusion Medicine and Transplant Immunology SIMT, Regional Reference Laboratory of Transplant Immunology LIT, Azienda Ospedaliera Universitaria AOU, 1st School of Medicine, Second University of Naples, 80138 Naples, Italy
    J Cell Biochem 114:7-20. 2013
  3. doi Unraveling framework of the ancestral Mediator complex in human diseases
    Claudio Napoli
    Department of General Pathology and Excellence Research Centre on Cardiovascular Diseases, 1st School of Medicine, Second University of Naples, Complesso S Andrea delle Dame Via Costantinopoli 16, 80138 Naples, Italy
    Biochimie 94:579-87. 2012
  4. ncbi Beneficial effects of autologous bone marrow cell infusion and antioxidants/L-arginine in patients with chronic critical limb ischemia
    Claudio Napoli
    Division of Clinical Pathology, Department of General Pathology, 1st School of Medicine, II University of Naples, Naples, Italy
    Eur J Cardiovasc Prev Rehabil 15:709-18. 2008
  5. doi Endothelial progenitor cells as therapeutic agents in the microcirculation: an update
    Claudio Napoli
    Department of General Pathology, Division of Clinical Pathology and Excellence Research Center on Cardiovascular Diseases, 1st School of Medicine, II University of Naples, 80138 Naples, Italy
    Atherosclerosis 215:9-22. 2011
  6. doi Directed in vivo angiogenesis assay and the study of systemic neoangiogenesis in cancer
    Claudio Napoli
    Department of General Pathology, 1st School of Medicine, II University of Naples, Naples, Italy
    Int J Cancer 128:1505-8. 2011
  7. doi Kidney and heart interactions during cardiorenal syndrome: a molecular and clinical pathogenic framework
    Claudio Napoli
    Dipartimento di Patologia Generale, Centro di Eccellenza sulle Malattie Cardiovascolari, Facolta di Medicina e Chirurgia, Seconda Universita di Napoli, Via Costantinopoli 16, 80138 Napoli, Italy
    Future Cardiol 7:485-97. 2011
  8. doi Long-term treatment with sulfhydryl angiotensin-converting enzyme inhibition reduces carotid intima-media thickening and improves the nitric oxide/oxidative stress pathways in newly diagnosed patients with mild to moderate primary hypertension
    Claudio Napoli
    Department of General Pathology and Excellence Research Center on Cardiovascular Diseases, and Microbiology Section, 1st School of Medicine, II University of Naples, Naples, Italy
    Am Heart J 156:1154.e1-8. 2008
  9. ncbi Therapeutic targeting of the stem cell niche in experimental hindlimb ischemia
    Claudio Napoli
    Department of General Pathology, 1st School of Medicine, II University of Naples, Naples, Italy
    Nat Clin Pract Cardiovasc Med 5:571-9. 2008
  10. doi Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis
    Claudio Napoli
    Department of General Pathology, Division of Clinical Pathology, 1st School of Medicine, II University of Naples, Complesso S Andrea delle Dame, Via L De Crecchio 7, Naples, 80138, Italy
    Heart Vessels 23:124-33. 2008

Collaborators

Detail Information

Publications85

  1. doi Maternal-foetal epigenetic interactions in the beginning of cardiovascular damage
    Claudio Napoli
    Department of General Pathology, Division of Clinical Pathology and Excellence Research Centre on Cardiovascular Disease, U O C Division of Immunohematology and Transplantation CRT, 1st School of Medicine, Complesso S Andrea delle Dame, Second University of Naples, 80138 Naples, Italy
    Cardiovasc Res 92:367-74. 2011
    ....
  2. doi Recent advances in proteomic technologies applied to cardiovascular disease
    Claudio Napoli
    Department of General Pathology, Excellence Research Centre on Cardiovascular Disease, U O C Immunohematology, Transfusion Medicine and Transplant Immunology SIMT, Regional Reference Laboratory of Transplant Immunology LIT, Azienda Ospedaliera Universitaria AOU, 1st School of Medicine, Second University of Naples, 80138 Naples, Italy
    J Cell Biochem 114:7-20. 2013
    ....
  3. doi Unraveling framework of the ancestral Mediator complex in human diseases
    Claudio Napoli
    Department of General Pathology and Excellence Research Centre on Cardiovascular Diseases, 1st School of Medicine, Second University of Naples, Complesso S Andrea delle Dame Via Costantinopoli 16, 80138 Naples, Italy
    Biochimie 94:579-87. 2012
    ..Mediator subunits have been emerging also to have pathophysiological roles suggesting MED-dependent therapeutic targets involving in several diseases, such as cancer, cardiovascular disease (CVD), metabolic and neurological disorders...
  4. ncbi Beneficial effects of autologous bone marrow cell infusion and antioxidants/L-arginine in patients with chronic critical limb ischemia
    Claudio Napoli
    Division of Clinical Pathology, Department of General Pathology, 1st School of Medicine, II University of Naples, Naples, Italy
    Eur J Cardiovasc Prev Rehabil 15:709-18. 2008
    ....
  5. doi Endothelial progenitor cells as therapeutic agents in the microcirculation: an update
    Claudio Napoli
    Department of General Pathology, Division of Clinical Pathology and Excellence Research Center on Cardiovascular Diseases, 1st School of Medicine, II University of Naples, 80138 Naples, Italy
    Atherosclerosis 215:9-22. 2011
    ..Overall, therapeutic angiogenesis will likely change the face of regenerative medicine in the next decade with many patients worldwide predicted to benefit from these treatments...
  6. doi Directed in vivo angiogenesis assay and the study of systemic neoangiogenesis in cancer
    Claudio Napoli
    Department of General Pathology, 1st School of Medicine, II University of Naples, Naples, Italy
    Int J Cancer 128:1505-8. 2011
    ..Thus, DIVAA studies systemic angiogenesis and its therapeutic modulation associated to cancer progression and metastasis...
  7. doi Kidney and heart interactions during cardiorenal syndrome: a molecular and clinical pathogenic framework
    Claudio Napoli
    Dipartimento di Patologia Generale, Centro di Eccellenza sulle Malattie Cardiovascolari, Facolta di Medicina e Chirurgia, Seconda Universita di Napoli, Via Costantinopoli 16, 80138 Napoli, Italy
    Future Cardiol 7:485-97. 2011
    ..More recently, epigenetics has opened new pathogenic molecular routes for CRS. This will lead to a more rapid development of novel, safe and effective clinical therapies...
  8. doi Long-term treatment with sulfhydryl angiotensin-converting enzyme inhibition reduces carotid intima-media thickening and improves the nitric oxide/oxidative stress pathways in newly diagnosed patients with mild to moderate primary hypertension
    Claudio Napoli
    Department of General Pathology and Excellence Research Center on Cardiovascular Diseases, and Microbiology Section, 1st School of Medicine, II University of Naples, Naples, Italy
    Am Heart J 156:1154.e1-8. 2008
    ..However, whether ACE inhibitors have any clinically significant antiatherogenic effects remains still debated...
  9. ncbi Therapeutic targeting of the stem cell niche in experimental hindlimb ischemia
    Claudio Napoli
    Department of General Pathology, 1st School of Medicine, II University of Naples, Naples, Italy
    Nat Clin Pract Cardiovasc Med 5:571-9. 2008
    ..Osteoblasts regulate the hematopoietic stem cell niche, and activation of the parathyroid hormone (PTH) receptor can increase the number of cells mobilized into the bloodstream...
  10. doi Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis
    Claudio Napoli
    Department of General Pathology, Division of Clinical Pathology, 1st School of Medicine, II University of Naples, Complesso S Andrea delle Dame, Via L De Crecchio 7, Naples, 80138, Italy
    Heart Vessels 23:124-33. 2008
    ..This evidence may have implications for the prevention of atherosclerotic lesion progression and its clinical manifestations...
  11. doi Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases
    Claudio Napoli
    Department of General Pathology and Excellence Research Center on Cardiovascular Diseases, University of Naples, Italy
    Arch Pharm Res 32:1103-8. 2009
    ....
  12. ncbi Therapeutic effects of concurrent autologous bone marrow cell infusion and metabolic intervention in ischemia-induced angiogenesis in the hypercholesterolemic mouse hindlimb
    Filomena de Nigris
    Department of General Pathology, Division of Clinical Pathology and Excellence Research Center on Cardiovascular Diseases, 1st School of Medicine, II University of Naples, Naples 80138, Italy
    Int J Cardiol 117:238-43. 2007
    ..This beneficial effect was amplified by metabolic cotreatment, an intervention inducing vascular protection, at least in part, through the nitric oxide pathway, reduction of systemic oxidative stress and macrophage activation...
  13. ncbi Therapeutic effects of autologous bone marrow cells and metabolic intervention in the ischemic hindlimb of spontaneously hypertensive rats involve reduced cell senescence and CXCR4/Akt/eNOS pathways
    Filomena de Nigris
    Department of General Pathology, Division of Clinical Pathology and Excellence Research Center on Cardiovascular Diseases, 1st School of Medicine, II University of Naples, Naples, Italy
    J Cardiovasc Pharmacol 50:424-33. 2007
    ..These data suggest potential therapeutic effects of autologous BMCs and metabolic treatment in hypertensive PAD patients...
  14. ncbi Antioxidants increase number of progenitor endothelial cells through multiple gene expression pathways
    Carmela Fiorito
    Department of General Pathology, Division of Clinical Pathology, Excellence Research Center of Cardiovascular Diseases, II University of Naples, Naples, Italy
    Free Radic Res 42:754-62. 2008
    ..Furthermore, concomitant antioxidant supplementation and physical training in vivo raised the levels of circulating EPCs and serum VEGF more than physical training alone...
  15. ncbi Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis
    Filomena de Nigris
    Department of General Pathology, School of Medicine, University of Naples, 80134 Naples, Italy
    Cardiovasc Res 73:414-23. 2007
    ..Polyphenolic antioxidants contained in the juice derived from the pomegranate contribute to the reduction of oxidative stress and atherogenesis during disturbed shear stress...
  16. ncbi Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients
    Francesco Cacciatore
    Cardiovascular Rehabilitation, Salvatore Maugeri Foundation, IRCCS, Institute of Telese, 82037, Benevento, Italy
    Eur J Clin Pharmacol 67:877-83. 2011
    ..The aim of the study was to evaluate EPC number, function, and relationship to carotid intima media thickness (IMT) progression...
  17. pmc Beneficial effects of concurrent autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the mouse hindlimb
    Claudio Napoli
    Department of General Pathology, Division of Clinical Pathology and Excellence Research Center on Cardiovascular Diseases, School of Medicine, Second University of Naples, Naples 80138, Italy
    Proc Natl Acad Sci U S A 102:17202-6. 2005
    ....
  18. doi Therapeutic dose of nebivolol, a nitric oxide-releasing beta-blocker, reduces atherosclerosis in cholesterol-fed rabbits
    Filomena de Nigris
    Department of General Pathology, Excellence Research Center on Cardiovascular Diseases, Complesso S Andrea della Dame, Via De Crecchio 7, 1st School of Medicine, II University of Naples, 80138 Naples, Italy
    Nitric Oxide 19:57-63. 2008
    ..These observations suggest that the NO-releasing beta-blocker, nebivolol, might represent an effective pharmacological approach for preventing atherosclerotic lesion progression...
  19. doi High glucose downregulates endothelial progenitor cell number via SIRT1
    Maria Luisa Balestrieri
    Department of Biochemistry and Biophysics, II University of Naples, Naples, Italy
    Biochim Biophys Acta 1784:936-45. 2008
    ..These findings show that SIRT1 is a critical modulator of EPCs dysfunction during alteration of glucose metabolism...
  20. doi Osteosarcoma cells induce endothelial cell proliferation during neo-angiogenesis
    Filomena de Nigris
    Department of General Pathology, UOC Immunohematology, and Excellence Research Centre on Cardiovascular Disease, 1st School of Medicine, Second University of Naples, Naples, Italy
    J Cell Physiol 228:846-52. 2013
    ..Present work suggests that Cdk2 and Cdk5 might be pharmacologically accessible targets for both antiangiogenic and antitumor therapy...
  21. doi Therapeutic angiogenesis in diabetic apolipoprotein E-deficient mice using bone marrow cells, functional hemangioblasts and metabolic intervention
    Maria Luisa Balestrieri
    Department of Biochemistry and Biophysics, 1st School of Medicine, II University of Naples, 80138 Naples, Italy
    Atherosclerosis 209:403-14. 2010
    ..Recently, hemangioblasts (HS) with functional properties were isolated...
  22. pmc Beneficial effects of pomegranate juice on oxidation-sensitive genes and endothelial nitric oxide synthase activity at sites of perturbed shear stress
    Filomena de Nigris
    Department of General Pathology, School of Medicine, University of Naples, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 102:4896-901. 2005
    ..This approach may have implications for the prevention or treatment of atherosclerosis and its clinical manifestations...
  23. ncbi Autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the diabetic mouse hindlimb
    Vincenzo Sica
    Department of General Pathology, Division of Clinical Pathology and Excellence Research Center on Cardiovascular Diseases, 1st School of Medicine, II University of Naples, Naples, Italy
    Cell Cycle 5:2903-8. 2006
    ..This effect was amplified by metabolic cotreatment, an intervention inducing vascular protection, at least in part, through the nitric oxide pathway, reduction of systemic oxidative stress, and macrophage activation...
  24. pmc CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy
    Filomena de Nigris
    Division of Clinical Pathology, Department of General Pathology, School of Medicine, Second University of Naples, 80138 Naples, Italy
    Proc Natl Acad Sci U S A 107:14484-9. 2010
    ..Thus, YY1 may represent a crucial molecular target for antiangiogenic therapy during cancer progression...
  25. doi Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis
    Filomena de Nigris
    Department of General Pathology, Division of Clinical Pathology, 1st School of Medicine, II University of Naples, Naples, Italy
    Cancer Res 68:1797-808. 2008
    ..In conclusion, YY1 and VEGF/CXCR4 seem to intervene in the pathogenesis of the malignant phenotype of osteosarcoma by acting on cell invasiveness and metastasis growth...
  26. ncbi Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease
    Antonio Liguori
    Department of Cardiology CCU, Hospital of Pellegrini ASL NA1, Naples, Italy
    Eur J Haematol 80:258-64. 2008
    ..05). CHD was also predictor of impaired CFU capacity. In this small clinical study, CHD is associated with selective impairment of HSC function in the BM and in the peripheral blood, which may contribute to impairment of cardiac function...
  27. doi Distinct alternative splicing patterns of mediator subunit genes during endothelial progenitor cell differentiation
    Monica Rienzo
    Department of General Pathology, Azienda Universitaria Policlinico AOU, 1st School of Medicine, Second University of Naples, Via L De Crecchio 7, 80138 Naples, Italy
    Biochimie 94:1828-32. 2012
    ..Here, we report two novel transcripts of MED12 and MED19 subunits both generated by alternative splicing and displaying similar expression patterns, thereby indicating their involvement during endothelial cell differentiation...
  28. doi Human leukocyte antigen-DR mismatch is associated with increased in-hospital mortality after a heart transplant
    Valeria Crudele
    Department of General Pathology and Excellence Research Centre on Cardiovascular Diseases, 1st School of Medicine Second University of Naples, Complesso S Andrea delle Dame Via Costantinopoli 16, Naples, 80138, Italy
    Exp Clin Transplant 11:346-51. 2013
    ....
  29. ncbi Current concepts in histocompatibility during heart transplant
    Antonietta Picascia
    UOC Immunohematology, Transfusion Medicine and Transplant Immunology, SIMT, Regional Reference Laboratory of Transplant Immunology, Department of General Pathology, Azienda Universitaria Policlinico, AOU, Second University of Naples, Naples, Italy
    Exp Clin Transplant 10:209-18. 2012
    ....
  30. doi Glycoxydation promotes vascular damage via MAPK-ERK/JNK pathways
    Filomena de Nigris
    Department of General Pathology, U O C Immunohematology, and Excellence Research Centre on Cardiovascular Disease, 1st School of Medicine, Second University of Naples, Naples, Italy
    J Cell Physiol 227:3639-47. 2012
    ..Thus, we provide a first line of evidence that MAPK-ERK/JNK pathways are involved in vascular damage induced by glycoxidation...
  31. ncbi Pomegranate juice reduces oxidized low-density lipoprotein downregulation of endothelial nitric oxide synthase in human coronary endothelial cells
    Filomena de Nigris
    Department of General Pathology and Excellence Research Center on Cardiovascular Disease, University of Naples, Italy
    Nitric Oxide 15:259-63. 2006
    ..Our data suggest that PJ can exert beneficial effects on the evolution of clinical vascular complications, coronary heart disease, and atherogenesis in humans by enhancing the NOSIII bioactivity...
  32. ncbi Bone marrow cell-mediated cardiovascular repair: potential of combined therapies
    Claudio Napoli
    Department of General Pathology, Division of Clinical Pathology and Excellence Research Center on Cardiovascular Diseases, 1st School of Medicine, II University of Naples, Italy
    Trends Mol Med 13:278-86. 2007
    ..We also consider the mechanisms of mobilization, differentiation and incorporation of BMCs...
  33. ncbi The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats
    Filomena de Nigris
    Department of General Pathology and Excellence Research Center on Cardiovascular Diseases, Complesso S Andrea delle Dame, Via De Crecchio 7, 1st School of Medicine, II University of Naples, Naples 80138, Italy
    Nitric Oxide 17:50-4. 2007
    ..05). Furthermore, the effect of PFE in increasing endothelial NO synthase (eNOS) expression was comparable to that of PJ. These data highlight possible clinical applications of PFE in metabolic syndrome...
  34. pmc Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice
    Claudio Napoli
    Department of General Pathology, Medicine, Clinical Pathology, and Human Pathology, University of Naples, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 101:8797-802. 2004
    ..Thus, metabolic intervention with l-arginine and antioxidants together with graduated and moderate exercise training reduce atherosclerotic lesion formation...
  35. doi Dual role of parathyroid hormone in endothelial progenitor cells and marrow stromal mesenchymal stem cells
    Giovanni Di Bernardo
    Department of Experimental Medicine, Biotechnology and Molecular Biology Section, Second University of Naples, Naples, Italy
    J Cell Physiol 222:474-80. 2010
    ..Taken together, our results may suggest a protective effect of PTH on MSCs that reduces stress phenomena and preserve genome integrity. At the opposite, PTH did not modify the fate of EPCs in culture...
  36. pmc Physical training and metabolic supplementation reduce spontaneous atherosclerotic plaque rupture and prolong survival in hypercholesterolemic mice
    Claudio Napoli
    Department of General Pathology, Division of Clinical Pathology, Excellence Research Center on Cardiovascular Diseases, Second University of Naples, Naples 80138, Italy
    Proc Natl Acad Sci U S A 103:10479-84. 2006
    ..Thus, early concerted actions of MT and PE improve the natural history of atherosclerotic lesions and reduce the plaque instability in hypercholesterolemic mice...
  37. doi Modification of the detrimental effect of TNF-α on human endothelial progenitor cells by fasudil and Y27632
    Maria Luisa Balestrieri
    Department of Biochemistry and Biophysics, II University of Naples, Naples 80138, Italy
    J Biochem Mol Toxicol 24:351-60. 2010
    ..These findings suggest that fasudil positively affects EPC number and that other major signals might take part to this complex pathway...
  38. ncbi Silencing of YY1 downregulates RIZ1 promoter in human osteosarcoma
    Ciro Abbondanza
    Department of General Pathology, 1st School of Medicine, II University of Naples, Naples 80138, Italy
    Oncol Res 17:33-41. 2008
    ..The coexpression of RIZ1/YY1 proteins suggests a tandem regulatory mechanism in human osteosarcoma cells and tissues...
  39. doi Effects of nitric oxide on cell proliferation: novel insights
    Claudio Napoli
    Department of General Pathology, Excellence Research Centre on Cardiovascular Diseases, U O C Immunohematology, Second University of Naples, Naples, Italy
    J Am Coll Cardiol 62:89-95. 2013
    ..This growing field may lead to broad and novel targeted therapies against cardiovascular diseases, especially concomitant type 2 diabetes, as well as novel bioimaging NO-based diagnostic tools...
  40. ncbi Identification of valid reference housekeeping genes for gene expression analysis in tumor neovascularization studies
    Monica Rienzo
    Department of General Pathology, Second University of Naples, Via L De Crecchio 7, 80138, Naples, Italy
    Clin Transl Oncol 15:211-8. 2013
    ..A common method is to report the interest gene expression relative to an internal control, usually a housekeeping gene (HKG), which should be constant in cells independently of experimental conditions...
  41. doi Repeated immune and non immune insults to the graft after heart transplantation
    Valeria Crudele
    Department of General Pathology and Excellence Research Centre on Cardiovascular Diseases, Second University of Naples, 1st School of Medicine, Naples, Italy
    Immunol Lett 141:18-27. 2011
    ..The aim of future studies could be to clarify the pathogenesis of chronic rejection and develop new and less toxic therapeutic approaches to induce "tolerance" to the graft without major side effects...
  42. pmc YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffering osteosarcoma
    Filomena de Nigris
    Department of General Pathology, Division of Clinical Pathology and U O C Immunohematology, Second University of Naples, 80138 Naples, Italy
    BMC Cancer 11:472. 2011
    ..We performed a prospective immunohistochemistry analysis to correlate YY1 immunostaining with metastatic development and survival in a selected homogeneous group of patients with osteosarcoma...
  43. doi Mediator subunits: gene expression pattern, a novel transcript identification and nuclear localization in human endothelial progenitor cells
    Monica Rienzo
    Department of General Pathology, 1st School of Medicine, II University of Naples, 80138 Naples, Italy
    Biochim Biophys Acta 1799:487-95. 2010
    ..Despite the need to confirm the in vivo presence of the protein of this novel isoform, the presence of this novel RNA raises the possibility of regulating pathophysiological mechanism in progenitors...
  44. ncbi Effect of low doses of red wine and pure resveratrol on circulating endothelial progenitor cells
    Maria Luisa Balestrieri
    Department of Biochemistry and Biophysics, II University of Naples, Naples, Italy
    J Biochem 143:179-86. 2008
    ..05) Indeed, pure Resv alone significantly improved the TNF-alpha reduced EPC number (P < 0.05). This evidence indicates novel beneficial effects of red wine and Resv in the positive modulation of EPCs levels...
  45. doi Novel pathogenic insights in the primary prevention of cardiovascular disease
    Claudio Napoli
    Department of General Pathology, Clinical Pathology and Excellence Research Center on Cardiovascular Diseases, 1st School of Medicine, II University of Naples, Complesso S Andrea delle Dame Via Costantinopoli 16, Naples, Italy
    Prog Cardiovasc Dis 51:503-23. 2009
    ..Stem cell therapy strategies have been evaluated for the treatment of CVD. Bone marrow and endothelial progenitor cells have been most extensively studied, suggesting that this approach may have beneficial effects on cardiac function...
  46. ncbi Therapeutic approaches in vascular repair induced by adult bone marrow cells and circulating progenitor endothelial cells
    Claudio Napoli
    Department of General Pathology, Division of Clinical Pathology and Excellence Research Center on Cardiovascular Diseases, 1st School of Medicine, II University of Naples, Italy
    Curr Pharm Des 13:3245-51. 2007
    ..Considering the limitations of adult stem cells especially in elderly subjects, our point of view is that BMCs or exogenous BMC/EPC are candidate for adjunct cell-therapy applications in vascular repair...
  47. doi Evidence of key role of Cdk2 overexpression in pemphigus vulgaris
    Alessandro Lanza
    Regional Center on Craniofacial Malformations, Clinical Odontostomatology, and Human Pathology, 1st School of Medicine and Surgery, II University of Naples, Naples, Italy
    J Biol Chem 283:8736-45. 2008
    ..Our data indicate that major Cdk2-dependent multiple gene regulatory events are present in PV. This alteration may influence the evolution of PV and its therapy...
  48. doi Potential benefits of cell therapy in coronary heart disease
    Vincenzo Grimaldi
    Department of Biochemistry, Biophysics, and General Pathology, Excellence Research Centre on Cardiovascular Disease, U O C Immunohematology, 1st School of Medicine, Second University of Naples, Naples, Italy
    J Cardiol 62:267-76. 2013
    ....
  49. doi Anti-HLA-A, -B, -DR, -DQB1 and -DQA1 antibodies reactive epitope determination with HLAMatchmaker in multipare awaiting list for heart transplant
    Marianna Resse
    U O C Immunohematology, Transfusion Medicine and Transplant Immunology SIMT, Regional Reference Laboratory of Transplant Immunology LIT, Azienda Universitaria Policlinico AOU, Second University of Naples, Italy
    Hum Immunol 74:937-41. 2013
    ..Thus, HLAMatchmaker software together with to solid phase techniques could open new horizons for a more precise characterization of the HLA-antibodies...
  50. doi Six-minute walking test but not ejection fraction predicts mortality in elderly patients undergoing cardiac rehabilitation following coronary artery bypass grafting
    Francesco Cacciatore
    Dipartimento di Medicina Clinica e Scienze, Cardiovascolari ed Immunologiche, Cattedra di Geriatria, University of Naples Federico II, Naples, Italy
    Eur J Prev Cardiol 19:1401-9. 2012
    ..Age-related effects on the ability of 6-min walking test (6MWT) and ejection fraction (EF) to predict mortality in coronary artery bypass grafting (CABG) patients undergoing cardiac rehabilitation (CR) is still debated...
  51. ncbi Adult stem cells and the clinical arena: are we able to widely use this therapy in patients with chronic limbs arteriopathy and ischemic ulcers without possibility of revascularization?
    Amelia Casamassimi
    Department of General Pathology, U O C Immunohematology, Second University of Naples, Naples, Italy
    Cardiovasc Hematol Agents Med Chem 10:99-108. 2012
    ..Indeed, several variables still remain to be elucidated for stem cell therapy, including the type of cells to be used, the infusion route, and more importantly, the stage of patients to be treated...
  52. pmc Impairment of circulating endothelial progenitors in Down syndrome
    Valerio Costa
    Institute of Genetics and Biophysics A, Buzzati Traverso, IGB CNR, Naples, Italy
    BMC Med Genomics 3:40. 2010
    ..The aim of our study was to elucidate some features of circulating endothelial progenitor cells in the context of this syndrome...
  53. pmc Massive-scale RNA-Seq analysis of non ribosomal transcriptome in human trisomy 21
    Valerio Costa
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Naples, Italy
    PLoS ONE 6:e18493. 2011
    ....
  54. ncbi Comparison between total endothelial progenitor cell isolation versus enriched Cd133+ culture
    Amelia Casamassimi
    Department of General Pathology, Division of Clinical Pathology and Excellence Research Center on Cardiovascular Diseases, II University of Naples, Italy
    J Biochem 141:503-11. 2007
    ..01) This may have relevance during intervention studies using cultured EPCs...
  55. doi Prominent cardioprotective effects of third generation beta blocker nebivolol against anthracycline-induced cardiotoxicity using the model of isolated perfused rat heart
    Filomena de Nigris
    Department of General Pathology, Division of Clinical Pathology, 1st School of Medicine and Surgery, II University of Naples, Complesso S Andrea delle Dame, Via L De Crecchio 7, 80138 Naples, Italy
    Eur J Cancer 44:334-40. 2008
    ..Combination with BB has shown a reduction in cardiac toxicity; in particular, nebivolol has exerted the most significant cardioprotective effect...
  56. doi Different expression of CD146 in human normal and osteosarcoma cell lines
    Concetta Schiano
    Department of General Pathology, Excellence Research Centre on Cardiovascular Disease, U O C Immunohematology, Transfusion Medicine and Transplant Immunology SIMT, Regional Reference Laboratory of Transplant Immunology LIT, Azienda Universitaria Policlinico AOU, 1st School of Medicine, Second University of Naples, Piazza Miraglia 2, 80138, Naples, Italy
    Med Oncol 29:2998-3002. 2012
    ..Moreover, CD146 overexpression was partially reduced in shYY1 cells, where the Yin Yang 1 transcription factor, also found over-expressed in human OS cells, has been silenced...
  57. pmc Evidence of Bacteroides fragilis protection from Bartonella henselae-induced damage
    Linda Sommese
    Division of Immunohematology, Transfusion Medicine and Transplant Immunology, Regional Reference Laboratory of Transplant Immunology, Azienda Universitaria Policlinico, 1st School of Medicine, Second University of Naples, Naples, Italy
    PLoS ONE 7:e49653. 2012
    ..fragilis colonization was also able to restore the EPC decrease observed in mice infected with B. henselae (0.65 vs 0.06 media). Thus, our data establish that B. fragilis colonization is able to prevent B. henselae damages through PSA...
  58. ncbi Rethinking primary prevention of atherosclerosis-related diseases
    Claudio Napoli
    Department of General Pathology and Excellence Research Center on Cardiovascular Diseases, 1st School of Medicine, II University of Naples, Complesso S Andrea delle Dame, Naples 80134, Italy
    Circulation 114:2517-27. 2006
  59. ncbi Body mass index and preinfarction angina in elderly patients with acute myocardial infarction
    Pasquale Abete
    Cattedra di Geriatria, Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università degli Studi di Naples Federico II, Naples, Italy
    Am J Clin Nutr 78:796-801. 2003
    ..Experimental evidence indicates that caloric restriction may restore ischemic preconditioning in aged animals...
  60. pmc Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet
    Claudio Napoli
    Department of Medicine, School of Medicine, University of Naples, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 100:2112-6. 2003
    ..These results support the concept that p66(Shc-/-) may play a pivotal role in controlling systemic oxidative stress and vascular diseases. Therefore, p66(Shc) might represent a molecular target for therapies against vascular diseases...
  61. ncbi RNA-Seq for the identification of novel Mediator transcripts in endothelial progenitor cells
    Monica Rienzo
    Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via L De Crecchio 7, 80138 Naples, Italy Electronic address
    Gene 547:98-105. 2014
    ..Finally, the expression profile of all MED genes, together with an extensive gene expression analysis, may be useful to better classify the diverse subsets of cell populations that contribute to neovascularization. ..
  62. doi Heart transplant with donor-specific antibody after immunoadsorption plus rituximab: a case report
    Marianna Resse
    Second University of Naples, Italy
    Prog Transplant 23:128-31. 2013
    ..After more than 2 years, graft function remains normal and the clinical status of the patient is stable...
  63. ncbi Proteomics and cardiovascular disease: an update
    Maria Luisa Balestrieri
    Department of Biochemistry and Biophysics, Complesso S Andrea delle Dame, 1st School of Medicine, II University of Naples, Naples, Italy
    Curr Med Chem 15:555-72. 2008
    ..Moreover, combination of proteomic biomarkers with clinical phenotype, metabolite changes, and genetic haplotype information is promising for the physician assessment of individual cardiovascular risk profile...
  64. ncbi CXCR4 inhibitors: tumor vasculature and therapeutic challenges
    Filomena de Nigris
    Department of General Pathology and Excellence Research Centre on Cardiovascular Diseases, 1st School of Medicine, Second University of Naples, Complesso S Andrea delle Dame, Via Costantinopoli 16, Naples, 80138, Italy
    Recent Pat Anticancer Drug Discov 7:251-64. 2012
    ..We have also considered other strategies, such RNA interference and miRNA, which could be tested for solid tumor adjuvant therapy...
  65. doi Understanding the immunoangiostatic CXC chemokine network
    Maria Luisa Balestrieri
    Department of Biochemistry and Biophysics, 1st School of Medicine, II University of Naples, Naples 80138, Italy
    Cardiovasc Res 78:250-6. 2008
    ..Here, we review insights on CXC chemokines in the context of immunoangiostasis and vascular damage...
  66. ncbi Nitric oxide and atherosclerosis: an update
    Claudio Napoli
    Department of General Pathology and Excellence Research Center on Cardiovascular Diseases, First School of Medicine, II University of Naples, Naples 80134, Italy
    Nitric Oxide 15:265-79. 2006
    ..Finally, eNOS gene polymorphism might be an additional risk factor that may contribute to predict cardiovascular events. However, further studies are needed to understand the possible clinical implications of these correlations...
  67. ncbi Expression of transcription factor Yin Yang 1 in human osteosarcomas
    Filomena de Nigris
    Department of General Pathology, Division of Clinical Pathology, 1st School of Medicine, II University of Naples, Italy
    Eur J Cancer 42:2420-4. 2006
    ....
  68. doi Developmental mechanisms involved in the primary prevention of atherosclerosis and cardiovascular disease
    Claudio Napoli
    Department of General Pathology and Excellence Research Centre on Cardiovascular Diseases, II University of Naples, 1st School of Medicine, Complesso S Andrea delle Dame Via Costantinopoli 16, Naples, Italy
    Curr Atheroscler Rep 13:170-5. 2011
    ....
  69. ncbi New advances in microarrays: finding the genes causally involved in disease
    Claudio Napoli
    Department of Medicine and Division of Clinical Pathology, University of Naples, Italy
    Methods Mol Med 108:215-33. 2005
    ..A projected decrease in cost and complexity may facilitate increased availability of this technology in the physician's office, and future applications may then allow tailoring of clinical diagnosis and targeted therapeutic strategies...
  70. doi Luminex and antibody detection in kidney transplantation
    Antonietta Picascia
    U O C Immunohematology, Transfusion Medicine and Transplant Immunology, Regional Reference Laboratory of Transplant Immunology, Azienda Universitaria Policlinico, Second University of Naples, Naples, Italy
    Clin Exp Nephrol 16:373-81. 2012
    ..However, there are still many unresolved issues, including the clinical relevance of antibodies detected with this system...
  71. ncbi Targeting c-Myc, Ras and IGF cascade to treat cancer and vascular disorders
    Filomena de Nigris
    Department of General Pathology, Division of Clinical Pathology and Excellence Research Center on Cardiovascular Diseases, 1st School of Medicine, II University of Naples, Italy
    Cell Cycle 5:1621-8. 2006
    ....
  72. ncbi Novel challenges in exploring peptide ligands and corresponding tissue-specific endothelial receptors
    Maria Luisa Balestrieri
    Department of Chemical Biology and Physics 1st School of Medicine, II University of Naples, Complesso S Andrea delle Dame, Naples 80138, Italy
    Eur J Cancer 43:1242-50. 2007
    ....
  73. doi Maternal C-reactive protein and developmental programming of atherosclerosis
    Antonio Liguori
    Regional Hospital of Pellegrini, Naples, Italy
    Am J Obstet Gynecol 198:281.e1-5. 2008
    ....
  74. ncbi Glycoxidation of low-density lipoprotein promotes multiple apoptotic pathways and NFkappaB activation in human coronary cells
    Filomena de Nigris
    Department of General Pathology and Excellence Research Center on Cardiovascular Diseases, II University of Naples, Via Luigi De Crecchio 7, Naples 80138, Italy
    Basic Res Cardiol 101:101-8. 2006
    ..This cascade of events may influence the evolution of atherogenesis and vascular complications in diabetic patients...
  75. ncbi Evidence of COX-1 and COX-2 expression in Kaposi's sarcoma tissues
    Luigi Rossiello
    Department of Dermatology, II University of Naples, Naples 80131, Italy
    Eur J Cancer 43:1232-41. 2007
    ..01 and P>0.03, respectively, for COX-2); (b) the extent and intensity staining for both COXs were higher in classic than in epidemic form of KS. Our data support the hypothesis that both COXs may be involved in the pathogenesis of KS...
  76. ncbi Targeting vascular niche by parathyroid hormone
    Caterina Pagliarulo
    Department of General Pathology, 1st School of Medicine, II University of Naples, Complesso S Andrea delle Dame, Via De Crecchio 7, 80138 Naples, Italy
    Curr Med Chem 15:2984-90. 2008
    ....
  77. ncbi Mediator complexes and eukaryotic transcription regulation: an overview
    Amelia Casamassimi
    Department of General Pathology, Division of Clinical Pathology, 1st School of Medicine, II University of Naples, Via L De Crecchio 7, 80138 Naples, Italy
    Biochimie 89:1439-46. 2007
    ....
  78. pmc Polymorphisms in endothelial nitric oxide synthase and carotid artery atherosclerosis
    Claudio Napoli
    Department of General Pathology, Division of Clinical Pathology, 1st School of Medicine, II University of Naples, Naples, Italy
    J Clin Pathol 60:341-4. 2007
  79. ncbi Statin treatment and the natural history of atherosclerotic-related diseases: pathogenic mechanisms and the risk-benefit profile
    Claudio Napoli
    Departments of Medicine and Clinical Pathology, University of Naples, Italy
    Curr Pharm Des 10:425-32. 2004
    ....
  80. ncbi New insights in the transcriptional activity and coregulator molecules in the arterial wall
    Filomena de Nigris
    Department of Medicine, University of Naples, PO Box 80131, Italy
    Int J Cardiol 86:153-68. 2002
    ..Increased understanding of the genetic and molecular basis of disease (e.g. transcriptional activity and its coregulation) will potentially enhance future diagnosis, treatment, and prevention of vascular diseases...
  81. doi New insights into cardiovascular and lipid metabolomics
    Alfonso Giovane
    Department of Biochemistry and Biophysics, Complesso S Andrea delle Dame, 1st School of Medicine, II University of Naples, Naples 80138, Italy
    J Cell Biochem 105:648-54. 2008
    ..This minireview provides an updated overview of alternative technical approaches for metabolomics studies and reviews initial applications of metabolomics that relate to both cardiovascular disease and lipid metabolism research...
  82. ncbi Efficacy of thrombolysis in younger and older adult patients suffering their first acute q-wave myocardial infarction
    Claudio Napoli
    Department of Clinical Medicine, Cardiovascular Science, and Immunology, School of Medicine, Federico II University, Naples, Italy
    J Am Geriatr Soc 50:343-8. 2002
    ..The goal of this study was to investigate the efficacy of thrombolysis in adult and older patients who suffered their first AMI...
  83. ncbi Oxidation of LDL, atherogenesis, and apoptosis
    Claudio Napoli
    Department of Medicine, University of Naples, Naples, Italy
    Ann N Y Acad Sci 1010:698-709. 2003
    ..When the precise role of oxLDL in vascular programmed cell death occurring in vivo is clarified, this may aid in the development of novel therapeutic approaches to adverse atherogenesis and its clinical sequelae...
  84. ncbi Nitric oxide and other novel therapies for pulmonary hypertension
    Claudio Napoli
    Department of Medicine, University of Naples, Naples, Italy
    J Cardiovasc Pharmacol Ther 9:1-8. 2004
    ....
  85. ncbi Cardioprotective effect of ischemic preconditioning is preserved in food-restricted senescent rats
    Pasquale Abete
    Cattedra di Geriatria, Dipartmento di Medicina Clinica, Scienze Cardiovasculari ed Immunologiche, Università degli studi di Napoli FedericoII, Naples, Italy
    Am J Physiol Heart Circ Physiol 282:H1978-87. 2002
    ..Thus caloric restriction may restore PC in the aging heart probably via increased norepinephrine release...