Raffaele Marfella

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. pmc Relationships between daily acute glucose fluctuations and cognitive performance among aged type 2 diabetic patients
    Maria Rosaria Rizzo
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Care 33:2169-74. 2010
  2. doi request reprint Peri-procedural tight glycemic control during early percutaneous coronary intervention up-regulates endothelial progenitor cell level and differentiation during acute ST-elevation myocardial infarction: effects on myocardial salvage
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases Second University of Naples, Italy Electronic address
    Int J Cardiol 168:3954-62. 2013
  3. doi request reprint Brief episodes of silent atrial fibrillation predict clinical vascular brain disease in type 2 diabetic patients
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Piazza Miraglia 2, Naples, Italy
    J Am Coll Cardiol 62:525-30. 2013
  4. pmc Dipeptidyl peptidase 4 inhibition may facilitate healing of chronic foot ulcers in patients with type 2 diabetes
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, 80138 Naples, Italy
    Exp Diabetes Res 2012:892706. 2012
  5. doi request reprint Peri-procedural tight glycemic control during early percutaneous coronary intervention is associated with a lower rate of in-stent restenosis in patients with acute ST-elevation myocardial infarction
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, 80138 Naples, Italy
    J Clin Endocrinol Metab 97:2862-71. 2012
  6. doi request reprint Tight glycemic control may increase regenerative potential of myocardium during acute infarction
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Piazza Miraglia, 2, 80138 Naples, Italy
    J Clin Endocrinol Metab 97:933-42. 2012
  7. ncbi request reprint Morning blood pressure surge as a destabilizing factor of atherosclerotic plaque: role of ubiquitin-proteasome activity
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples, Italy
    Hypertension 49:784-91. 2007
  8. ncbi request reprint Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus
    R Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabet Med 23:974-81. 2006
  9. ncbi request reprint Increased activity of the ubiquitin-proteasome system in patients with symptomatic carotid disease is associated with enhanced inflammation and may destabilize the atherosclerotic plaque: effects of rosiglitazone treatment
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Section of Pathology, Second University of Naples, Naples, Italy
    J Am Coll Cardiol 47:2444-55. 2006
  10. ncbi request reprint The ubiquitin-proteasome system and inflammatory activity in diabetic atherosclerotic plaques: effects of rosiglitazone treatment
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University Naples, Italy
    Diabetes 55:622-32. 2006

Collaborators

Detail Information

Publications94

  1. pmc Relationships between daily acute glucose fluctuations and cognitive performance among aged type 2 diabetic patients
    Maria Rosaria Rizzo
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Care 33:2169-74. 2010
    ....
  2. doi request reprint Peri-procedural tight glycemic control during early percutaneous coronary intervention up-regulates endothelial progenitor cell level and differentiation during acute ST-elevation myocardial infarction: effects on myocardial salvage
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases Second University of Naples, Italy Electronic address
    Int J Cardiol 168:3954-62. 2013
    ....
  3. doi request reprint Brief episodes of silent atrial fibrillation predict clinical vascular brain disease in type 2 diabetic patients
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Piazza Miraglia 2, Naples, Italy
    J Am Coll Cardiol 62:525-30. 2013
    ....
  4. pmc Dipeptidyl peptidase 4 inhibition may facilitate healing of chronic foot ulcers in patients with type 2 diabetes
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, 80138 Naples, Italy
    Exp Diabetes Res 2012:892706. 2012
    ..Although elucidation of the pathophysiologic importance of these aspects awaits further confirmations, the present study evidences an additional aspect of how DPP-4 inhibition might contribute to improved ulcer outcome...
  5. doi request reprint Peri-procedural tight glycemic control during early percutaneous coronary intervention is associated with a lower rate of in-stent restenosis in patients with acute ST-elevation myocardial infarction
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, 80138 Naples, Italy
    J Clin Endocrinol Metab 97:2862-71. 2012
    ..We examined the effects of peri-procedural intensive glycemic control (IGC) during early percutaneous coronary intervention (PCI) on restenosis rate in hyperglycemic patients with ST-segment elevation myocardial infarction (STEMI)...
  6. doi request reprint Tight glycemic control may increase regenerative potential of myocardium during acute infarction
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Piazza Miraglia, 2, 80138 Naples, Italy
    J Clin Endocrinol Metab 97:933-42. 2012
    ..We analyzed the effects of tight glycemic control on regenerative potential of myocardium during acute myocardial infarction...
  7. ncbi request reprint Morning blood pressure surge as a destabilizing factor of atherosclerotic plaque: role of ubiquitin-proteasome activity
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples, Italy
    Hypertension 49:784-91. 2007
    ..These data suggest a potential interplay between morning blood pressure surge and ubiquitin-proteasome activity in atherosclerosis pathophysiology...
  8. ncbi request reprint Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus
    R Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabet Med 23:974-81. 2006
    ....
  9. ncbi request reprint Increased activity of the ubiquitin-proteasome system in patients with symptomatic carotid disease is associated with enhanced inflammation and may destabilize the atherosclerotic plaque: effects of rosiglitazone treatment
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Section of Pathology, Second University of Naples, Naples, Italy
    J Am Coll Cardiol 47:2444-55. 2006
    ..We evaluated ubiquitin-proteasome activity in carotid plaques of asymptomatic and symptomatic patients and the effect of rosiglitazone, a peroxisome proliferator-activated receptor-gamma activator, in symptomatic plaques...
  10. ncbi request reprint The ubiquitin-proteasome system and inflammatory activity in diabetic atherosclerotic plaques: effects of rosiglitazone treatment
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University Naples, Italy
    Diabetes 55:622-32. 2006
    ....
  11. pmc The possible role of the ubiquitin proteasome system in the development of atherosclerosis in diabetes
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Cardiovasc Diabetol 6:35. 2007
    ....
  12. ncbi request reprint Regression of carotid atherosclerosis by control of morning blood pressure peak in newly diagnosed hypertensive patients
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples, Italy
    Am J Hypertens 18:308-18. 2005
    ....
  13. ncbi request reprint Expression of angiogenic factors during acute coronary syndromes in human type 2 diabetes
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Section of Pathology, Second University of Naples, Naples, Italy
    Diabetes 53:2383-91. 2004
    ..001). Diabetes is associated with increased myocardial tissue levels of iNOS, O(2)(-), and nitrotyrosine and reduced expression of myocardial angiogenesis factors during ischemia...
  14. ncbi request reprint Absence of inducible nitric oxide synthase reduces myocardial damage during ischemia reperfusion in streptozotocin-induced hyperglycemic mice
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes 53:454-62. 2004
    ..The beneficial role of iNOS in modulating defensive responses against ischemia/reperfusion injury seems to be abolished in diabetic mice...
  15. doi request reprint Proteasome activity as a target of hormone replacement therapy-dependent plaque stabilization in postmenopausal women
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Second University Naples, Naples, Italy
    Hypertension 51:1135-41. 2008
    ..This effect, in turn, might contribute to plaque stabilization by inhibiting the activation of nuclear factor kappaB-dependent inflammation, responsible for plaque rupture...
  16. ncbi request reprint Effects of ubiquitin-proteasome system deregulation on the vascular senescence and atherosclerosis process in elderly patients
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    J Gerontol A Biol Sci Med Sci 63:200-3. 2008
    ..The role of the ubiquitin-proteasome system in the vascular senescence and atherosclerotic progression of elderly patients is unclear. We evaluated ubiquitin-proteasome activity in carotid plaques of asymptomatic elderly and adult patients...
  17. doi request reprint Innate immune activity in plaque of patients with untreated and L-thyroxine-treated subclinical hypothyroidism
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Seconda Università Napoli, 80138 Napoli, Italy
    J Clin Endocrinol Metab 96:1015-20. 2011
    ..A strong association between subclinical hypothyroidism (SCH) and atherosclerotic diseases, independent of the traditional risk factors, was noted...
  18. pmc Bariatric surgery reduces oxidative stress by blunting 24-h acute glucose fluctuations in type 2 diabetic obese patients
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Care 33:287-9. 2010
    ..We evaluated the efficacy of malabsorptive bariatric surgery on daily blood glucose fluctuations and oxidative stress in type 2 diabetic obese patients...
  19. doi request reprint Role of subcutaneous abdominal fat on cardiac function and proinflammatory cytokines in premenopausal obese women
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Ann Plast Surg 63:490-5. 2009
    ..Abdominoplasty may represent a safe method for ameliorating cardiac function in obese women...
  20. doi request reprint Use of a non-specific immunomodulation therapy as a therapeutic vasculogenesis strategy in no-option critical limb ischemia patients
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Piazza Miraglia, 2 80138 Napoli, Italy
    Atherosclerosis 208:473-9. 2010
    ..We tested the hypothesis that administration of an oxygen/ozone mixture (IMT) might counteract this pathophysiological mechanism and enhance limb tissue perfusion in patients with critical limb ischemia (CLI)...
  21. pmc Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    J Lipid Res 50:2314-23. 2009
    ..001). SREBP-1c may contribute to heart dysfunction by promoting lipid accumulation within myocytes in MS patients with AS; SREBP-1c may do it by increasing the levels of PPARgamma protein...
  22. doi request reprint Effects of vildagliptin twice daily vs. sitagliptin once daily on 24-hour acute glucose fluctuations
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases Second University of Naples, Naples, Italy
    J Diabetes Complications 24:79-83. 2010
    ..Since MAGE is associated with an activation of oxidative stress, our data suggest that dipeptidyl peptidase IV inhibition therapy should target not only reducing HbA(1c) but also flattening acute glucose fluctuations over a daily period...
  23. doi request reprint The ubiquitin-proteasome system contributes to the inflammatory injury in ischemic diabetic myocardium: the role of glycemic control
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Cardiovasc Pathol 18:332-45. 2009
    ..Finally, this study aimed to elucidate whether an intervention on UPS with bortezomib, an inhibitor of UPS, may counteract the extensive myocardial infarction and increased inflammatory reaction into the hyperglycemic myocardium...
  24. doi request reprint Shear stress as target to reduce atherosclerosis progression in hypertensive patients
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples, Italy
    Am J Hypertens 21:729. 2008
  25. ncbi request reprint Effect of weight loss on cardiac synchronization and proinflammatory cytokines in premenopausal obese women
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Care 27:47-52. 2004
    ..We examined the relationship of ventricular synchronization abnormalities with the concentration of proinflammatory cytokines in obese women at baseline and after sustained weight loss...
  26. ncbi request reprint Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1
    R Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Diabetologia 45:1172-81. 2002
    ..This study aimed to evaluate the effects of hyperglycaemia on the evolution of myocardial infarction and the expression of the transcriptional factor for angiogenesis hypoxia-inducible factor 1alpha (HIF-1alpha) in the rat...
  27. ncbi request reprint Morning blood pressure peak, QT intervals, and sympathetic activity in hypertensive patients
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples Italy
    Hypertension 41:237-43. 2003
    ..The prolongation of cardiac repolarization times and morning sympathetic overactivity coexist in hypertensive patients with morning BP peaks, and they might contribute to raised cardiovascular risk in these patients...
  28. doi request reprint Tight glycemic control reduces heart inflammation and remodeling during acute myocardial infarction in hyperglycemic patients
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    J Am Coll Cardiol 53:1425-36. 2009
    ..We analyzed the molecular mechanisms evoked by tight glycemic control during post-infarction remodeling in human hearts...
  29. ncbi request reprint Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial
    Katherine Esposito
    Chair and Division of Metabolic Diseases, Second University of Naples, Naples, Italy
    JAMA 292:1440-6. 2004
    ..The metabolic syndrome has been identified as a target for dietary therapies to reduce risk of cardiovascular disease; however, the role of diet in the etiology of the metabolic syndrome is poorly understood...
  30. ncbi request reprint Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Policlinico Universitario, Piazza L Miraglia, 80138 Naples, Italy
    Circulation 110:214-9. 2004
    ....
  31. ncbi request reprint Sympathovagal balance, nighttime blood pressure, and QT intervals in normotensive obese women
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Cardiovascular Research Center, Second University of Naples, Naples, Italy
    Obes Res 11:653-9. 2003
    ..We describe associations among the heart-rate-corrected QT (QTc) interval, QTc dispersion (QTc-d), circadian BP variation, and autonomic function in obese normotensive women and the effect of sustained weight loss...
  32. ncbi request reprint Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year
    Patrizia Ziccardi
    Department of Geriatrics and Metabolic Diseases, Chair of Metabolic Diseases, Second University of Naples, Italy
    Circulation 105:804-9. 2002
    ..Visceral fat is a key regulator site for the process of inflammation, and atherosclerotic lesions are essentially an inflammatory response...
  33. ncbi request reprint M40403 prevents myocardial injury induced by acute hyperglycaemia in perfused rat heart
    Clara Di Filippo
    Department of Experimental Medicine, Second University of Naples, Naples, Italy
    Eur J Pharmacol 497:65-74. 2004
    ..Therefore, synthetic enzymes of SOD, such as M40403, offer a novel therapeutic approach for the management of various cardiovascular diseases where these radicals have been postulated to play a role...
  34. ncbi request reprint Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial
    Katherine Esposito
    Center for Obesity Management, Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    JAMA 289:1799-804. 2003
    ..Obesity is an independent risk factor for cardiovascular disease, which may be mediated by increased secretion of proinflammatory cytokines by adipose tissue...
  35. doi request reprint The -8 UTR C/G polymorphism of PSMA6 gene is associated with susceptibility to myocardial infarction in type 2 diabetic patients
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Piazza Miraglia 2, 80138 Naples, Italy
    Atherosclerosis 201:117-23. 2008
    ....
  36. ncbi request reprint Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals
    Francesco Nappo
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    J Am Coll Cardiol 39:1145-50. 2002
    ..To compare the effect of a high-fat meal and a high-carbohydrate meal (pizza), with and without antioxidant vitamins, on endothelial activation in healthy subjects and in patients with type 2 diabetes mellitus...
  37. ncbi request reprint Is the aging heart similar to the diabetic heart? Evaluation of LV function of the aging heart with Tissue Doppler Imaging
    Fulvio Cacciapuoti
    Echocardiography, Department of Geriatrics and Metabolic Disease, II University of Naples, Naples, Italy
    Aging Clin Exp Res 21:22-6. 2009
    ..Left ventricular (LV) function in the healthy aging heart is modified by biochemical changes with advancing age. We employed for the first time Tissue Doppler Imaging (TDI), to identify which phase of the cardiac cycle is involved...
  38. ncbi request reprint Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress
    Katherine Esposito
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Italy
    Circulation 106:2067-72. 2002
    ..We assessed the role of glucose in the regulation of circulating levels of IL-6, TNF-alpha, and interleukin-18 (IL-18) in subjects with normal or impaired glucose tolerance (IGT), as well as the effect of the antioxidant glutathione...
  39. ncbi request reprint Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial
    Katherine Esposito
    Center for Obesity Management, Second University of Naples, Naples, Italy
    JAMA 291:2978-84. 2004
    ..Healthy lifestyle factors are associated with maintenance of erectile function in men...
  40. ncbi request reprint Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Am J Clin Nutr 77:139-43. 2003
    ..Persons following current dietary guidelines have a lower risk of mortality from coronary heart disease...
  41. ncbi request reprint Effects of stress hyperglycemia on acute myocardial infarction: role of inflammatory immune process in functional cardiac outcome
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Care 26:3129-35. 2003
    ..We examined the association between plasma glucose levels, circulating inflammatory markers, T-cell activation, and functional cardiac outcome in patients with first MI...
  42. pmc Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-IV inhibition
    Maria Rosaria Rizzo
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Care 35:2076-82. 2012
    ....
  43. ncbi request reprint Effects of insulin on left ventricular function during dynamic exercise in overweight and obese subjects
    Ferdinando C Sasso
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Eur Heart J 26:1205-12. 2005
    ..We designed this study in order to determine the effect of insulin on cardiac function in overweight and obese subjects during exercise...
  44. ncbi request reprint High glucose induces ventricular instability and increases vasomotor tone in rats
    R Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetologia 44:464-70. 2001
    ..By increasing the production of free radicals, high glucose could reduce nitric oxide availability to target cells inducing a state of increased vasomotor tone and ventricular instability...
  45. doi request reprint Oxygen/ozone protects the heart from acute myocardial infarction through local increase of eNOS activity and endothelial progenitor cells recruitment
    Clara Di Filippo
    Department of Experimental Medicine, Second University of Naples, Via Costantinopoli 16, Naples, Italy
    Naunyn Schmiedebergs Arch Pharmacol 382:287-91. 2010
    ..O(2)/O(3) mixture protects the heart from acute myocardial infarction through local increase of eNOS expression/activity and consequent EPCs recruitment...
  46. ncbi request reprint Hyperglycemia in streptozotocin-induced diabetic rat increases infarct size associated with low levels of myocardial HO-1 during ischemia/reperfusion
    Clara Di Filippo
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Italy
    Diabetes 54:803-10. 2005
    ..This recovered the huge number of infiltrated polymorphonuclear (PMN) leukocytes within the cardiac tissue associated with the STZ hyperglycemic state and I/R damage...
  47. ncbi request reprint Hemodynamic effects of acute hyperglycemia in type 2 diabetic patients
    R Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Diabetes Care 23:658-63. 2000
    ..The aim of the present study was to evaluate the hemodynamic effects of acute hyperglycemia in type 2 diabetic patients and to see whether these effects are related to changes in nitric oxide (NO) availability...
  48. ncbi request reprint Autonomic dysfunction associates with prolongation of QT intervals and blunted night BP in obese women with visceral obesity
    K Esposito
    Department of Geriatrics and Metabolic Disease, Second University of Naples, Naples, Italy
    J Endocrinol Invest 25:RC32-5. 2002
    ..Autonomic dysfunction may be the common mechanism for this association...
  49. ncbi request reprint Increased vascular endothelial growth factor expression but impaired vascular endothelial growth factor receptor signaling in the myocardium of type 2 diabetic patients with chronic coronary heart disease
    Ferdinando Carlo Sasso
    Department of Geriatrics and Metabolic Disease, Second University of Naples, Naples, Italy
    J Am Coll Cardiol 46:827-34. 2005
    ..The aim of the present study was to evaluate the expression and the activity of vascular endothelial growth factor (VEGF) in the hearts of diabetic patients with chronic coronary heart disease (CHD)...
  50. ncbi request reprint Insulin resistance and postprandial hyperglycemia the bad companions in natural history of diabetes: effects on health of vascular tree
    Clara Di Filippo
    Department of Experimental Medicine, 2nd University of Naples, Via Costantinopoli 16, Naples, Italy
    Curr Diabetes Rev 3:268-73. 2007
    ..It also adds insights of why diverse therapeutic interventions, which have in common the ability to reduce oxidative stress and inflammation, can impede or delay the onset of complication of atherosclerosis in diabetic patients...
  51. pmc Effects of PPARs agonists on cardiac metabolism in littermate and cardiomyocyte-specific PPAR-γ-knockout (CM-PGKO) mice
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy
    PLoS ONE 7:e35999. 2012
    ..Nevertheless a direct non-PPARγ mediated mechanism of PPARγ agonist could not be ruled out...
  52. ncbi request reprint FFAs and QT intervals in obese women with visceral adiposity: effects of sustained weight loss over 1 year
    Grazia Maria Corbi
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples 80138, Italy
    J Clin Endocrinol Metab 87:2080-3. 2002
    ....
  53. ncbi request reprint Erectile dysfunction associates with endothelial dysfunction and raised proinflammatory cytokine levels in obese men
    F Giugliano
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    J Endocrinol Invest 27:665-9. 2004
    ....
  54. ncbi request reprint Circulating microRNA changes in heart failure patients treated with cardiac resynchronization therapy: responders vs. non-responders
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Eur J Heart Fail 15:1277-88. 2013
    ..We studied whether LV reverse remodelling after CRT was associated with changes of circulating miRNAs in patients with heart failure (HF) and dyssynchrony...
  55. pmc Association of genetic variation in adaptor protein APPL1/APPL2 loci with non-alcoholic fatty liver disease
    Michelangela Barbieri
    Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Second University of Naples, Naples, Italy
    PLoS ONE 8:e71391. 2013
    ..88; 95% CI 1.582-9.531; p<0.001). In conclusion, C-APPL1/A-APPL2 allele combination is associated with NAFLD occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin cytoprotective effect on liver. ..
  56. ncbi request reprint Oxidative stress as the leading cause of acute myocardial infarction in diabetics
    Clara Di Filippo
    Department of Experimental Medicine, Second Univeristy of Naples, Naples, Italy
    Cardiovasc Drug Rev 24:77-87. 2006
    ....
  57. ncbi request reprint Association of low interleukin-10 levels with the metabolic syndrome in obese women
    Katherine Esposito
    Center for Obesity Management, Department of Geriatrics and Metabolic Diseases, Second University of Naples, 80138 Naples, Italy
    J Clin Endocrinol Metab 88:1055-8. 2003
    ..These results show that circulating levels of the anti-inflammatory cytokine IL-10 are elevated in obese women and that low IL-10 levels are associated with the metabolic syndrome...
  58. pmc Mediterranean diet, telomere maintenance and health status among elderly
    Virginia Boccardi
    Department of Internal Medicine, Surgical, Neurological Metabolic Disease and Geriatric Medicine, Second University of Naples, Naples, Italy
    PLoS ONE 8:e62781. 2013
    ..048). These results support a novel role of MD in promoting health-span suggesting that telomere maintenance, rather than LTL variability is the major determinant of healthy status among elderly...
  59. ncbi request reprint High proportions of erectile dysfunction in men with the metabolic syndrome
    Katherine Esposito
    Division of Metabolic Diseases, Second University of Naples, Piazza L Miraglia, 80138 Naples, Italy
    Diabetes Care 28:1201-3. 2005
  60. ncbi request reprint Endothelin-1 receptor antagonists reduce cardiac electrical instability induced by high glucose in rats
    Clara Di Filippo
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Via Costantinopoli 16, 80138 Naples, Italy
    Naunyn Schmiedebergs Arch Pharmacol 366:193-7. 2002
    ..Antagonism at cardiac ET receptors could be helpful in these cardiovascular complications of diabetes...
  61. doi request reprint Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice
    Michele D'Amico
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Naples, Italy
    Exp Gerontol 45:202-7. 2010
    ..The long-term inhibition of the endogenous DPP-4 enzymes with sitagliptin can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD...
  62. doi request reprint High cardiovascular risk in patients with Type 2 diabetic nephropathy: the predictive role of albuminuria and glomerular filtration rate. The NID-2 Prospective Cohort Study
    Ferdinando C Sasso
    Department of Internal and Experimental Medicine, Second University of Naples, Naples, Italy
    Nephrol Dial Transplant 27:2269-74. 2012
    ..In this high-risk population, cardiovascular (CV) outcome has never been evaluated...
  63. ncbi request reprint Effect of postprandial hyperglycaemia on blood viscosity in aged patients suffering from type 2 diabetes as compared with healthy volunteers
    Ludovico Coppola
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Blood Coagul Fibrinolysis 18:745-50. 2007
    ....
  64. ncbi request reprint Glucose metabolism and coronary heart disease in patients with normal glucose tolerance
    Ferdinando C Sasso
    Institutes of Internal Medicine, Faculty of Medicine, Second University of Naples, Naples, Italy
    JAMA 291:1857-63. 2004
    ....
  65. doi request reprint Acute oxygen-ozone administration to rats protects the heart from ischemia reperfusion infarct
    C Di Filippo
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Inflamm Res 57:445-9. 2008
    ..We tested here the effects of acute administration of an oxygen/ozone (O3) mixture on the myocardial tissue damage following an ischemic event...
  66. ncbi request reprint The metabolic syndrome: a cause of sexual dysfunction in women
    K Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Int J Impot Res 17:224-6. 2005
    ..8 (0.2/2.9) mg/l, median (interquartile range), P = 0.01). There was an inverse relation between CRP levels and FSFI score (r = -0.32, P=0.02). Investigation of female sexuality is suggested for patients with the metabolic syndrome...
  67. doi request reprint A new pleiotropic effect of statins in elderly: modulation of telomerase activity
    Virginia Boccardi
    Department of Internal Medicine, Surgical, Neurological, Metabolic Disease and Geriatric Medicine, Second University of Naples, P zza Miraglia 2, 80138 Naples, Italy
    FASEB J 27:3879-85. 2013
    ..0001). In summary, statins, modulating telomerase activity, affect telomere erosion along with aging...
  68. ncbi request reprint Impairment of coronary circulation by acute hyperhomocysteinemia in type 2 diabetic patients
    Antonino Coppola
    Second University of Naples, Department of Geriatrics and Metabolic Diseases, Piazza L Miraglia, 80138 Naples, Italy
    Diabetes Care 27:2055-6. 2004
  69. ncbi request reprint Hemodynamic and metabolic effects of transdermal clonidine in patients with hypertension and non-insulin-dependent diabetes mellitus
    D Giugliano
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Am J Hypertens 11:184-9. 1998
    ..Transdermal clonidine is effective in reducing blood pressure in hypertensive NIDDM patients and is well tolerated. It may be useful to reduce the cardiovascular impact of hypertension in diabetes mellitus...
  70. ncbi request reprint Comparison of nitrendipine and cilazapril in patients with hypertension and non-insulin-dependent diabetes mellitus
    D Giugliano
    Department of Geriatrics and Metabolic Diseases, Faculty of Medicine, Second University of Naples, Italy
    Am J Hypertens 6:927-32. 1993
    ..5%, respectively. Only nitrendipine reduced glucose-stimulated insulin levels. Nitrendipine is as effective as cilazapril in lowering diastolic blood pressure and LVMI levels and in increasing glucose disposal levels in these patients...
  71. ncbi request reprint Hyperglycemia and heart dysfunction: an oxidant mechanism contributing to heart failure in diabetes
    K Esposito
    Department of Geriatrics and Metabolic Diseases, Cardiovascular Research Centre, Second University of Naples, Italy
    J Endocrinol Invest 25:485-8. 2002
  72. ncbi request reprint Role of the ubiquitin-proteasome system in carotid plaque instability in diabetic patients
    Raffaele Marfella
    Center of Cardiovascular Research, Second University of Naples, Italy
    Acta Cardiol 61:630-6. 2006
    ..This induces the NFkB release into the nucleus which, in turn, is responsible for the expression of inflammatory cytokines causing plaque rupture...
  73. ncbi request reprint The BB-paraoxonase genotype is associated with impaired brachial reactivity after acute hypertriglyceridemia in healthy subjects
    G Paolisso
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, I 80138 Naples, Italy
    J Clin Endocrinol Metab 86:1078-82. 2001
    ..In conclusion, our study demonstrates that transient HT decreases vascular reactivity more in subjects with the PON BB genotype than in those with the other PON genotypes...
  74. ncbi request reprint LL-paraoxonase genotype is associated with a more severe degree of homeostasis model assessment IR in healthy subjects
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, I 80138 Naples, Italy
    J Clin Endocrinol Metab 87:222-5. 2002
    ..001). In conclusion, the presence of LL PON genotype is associated with a more severe degree of IR. Thus, IR might be the possible missing link between Met-Leu 54 PON polymorphism and the increased cardiovascular risk...
  75. ncbi request reprint Simvastatin normalizes qtc dispersion and reduces ventricular electrical instability in isolated hypercholesterolemia
    P Gualdiero
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    J Endocrinol Invest 25:RC16-8. 2002
    ..37, p<0.01) and QTc dispersion (r=0.49, p<0.01). In subjects with isolated hypercholesterolemia simvastatin may reduce the cardiovascular risk associated with ventricular electrical instability...
  76. doi request reprint Dipeptidyl peptidase-4 inhibitors in the elderly: more benefits or risks?
    Giuseppe Paolisso
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy
    Adv Ther 29:218-33. 2012
    ..Due to their characteristics, DPP-4 inhibitors seem to be particularly interesting as potential agents for the treatment of older patients with T2DM...
  77. doi request reprint -94 ins/del ATTG NFKB1 gene variant is associated with lower susceptibility to myocardial infarction
    V Boccardi
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Piazza Miraglia 2, Naples, Italy
    Nutr Metab Cardiovasc Dis 21:679-84. 2011
    ..We aimed to evaluate the relationship between NFKB1 and NFKBIA polymorphism and susceptibility to myocardial infarction (MI)...
  78. doi request reprint Possible dual role of ubiquitin-proteasome system in the atherosclerotic plaque progression
    Clara Di Filippo
    J Am Coll Cardiol 52:1350-1; author reply 1351. 2008
  79. ncbi request reprint Plasma interleukin-18 concentrations are elevated in type 2 diabetes
    Katherine Esposito
    Diabetes Care 27:272. 2004
  80. ncbi request reprint Effect of high glucose on vasculature
    Raffaele Marfella
    Circulation 108:e74; author reply e74. 2003
  81. doi request reprint Insulin therapy and lipid overload in type 2 diabetes
    Raffaele Marfella
    JAMA 300:789; author reply 790. 2008
  82. ncbi request reprint Morning blood pressure surge and the risk of stroke
    Raffaele Marfella
    Circulation 108:e110-1; author reply e110-1. 2003
  83. ncbi request reprint Diabetes, ubiquitin proteasome system and atherosclerotic plaque rupture
    Raffaele Marfella
    Circ Res 100:e84-5. 2007
  84. pmc Insulin resistance and cognitive decline may be common soil for frailty syndrome
    Angela Marie Abbatecola
    Arch Intern Med 167:2145-6. 2007
  85. ncbi request reprint Increase in nocturnal blood pressure and progression to microalbuminuria in diabetes
    Raffaele Marfella
    N Engl J Med 348:260-4; author reply 260-4. 2003
  86. ncbi request reprint The vascular smooth muscle cells apoptosis in asymptomatic diabetic carotid plaques: role of glycemic control
    Raffaele Marfella
    J Am Coll Cardiol 47:2118-20. 2006
  87. ncbi request reprint Stress hyperglycemia, inflammation, and cardiovascular events
    Katherine Esposito
    Diabetes Care 26:1650-1. 2003
  88. ncbi request reprint Myocardial infarction and hyperglycemia
    Raffaele Marfella
    Am J Cardiol 96:1468. 2005
  89. ncbi request reprint Ventricular remodeling does not accompany the development of heart failure in diabetic patients after myocardial infarction
    Raffaele Marfella
    Circulation 107:e85; author reply e85. 2003
  90. ncbi request reprint The effect of weight loss on endothelial functions in obesity: response to Sciacqua et al
    Katherine Esposito
    Diabetes Care 26:2968-9. 2003
  91. ncbi request reprint Sexual dysfunction in women with the metabolic syndrome
    Katherine Esposito
    Diabetes Care 28:756. 2005
  92. ncbi request reprint Letter regarding article by Ferriera et al, "postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles"
    Dario Giugliano
    Circulation 111:e457-8; author reply e457-8. 2005
  93. ncbi request reprint Acute hyperglycemia induces nitrotyrosine formation and apoptosis in perfused heart from rat
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Udine, Italy
    Diabetes 51:1076-82. 2002
    ....
  94. ncbi request reprint Fitness versus fatness: the debate continues
    Katherine Esposito
    Arterioscler Thromb Vasc Biol 25:e20-1; author reply e20-1. 2005