Vittorio Gentile

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. ncbi Tissue transglutaminase and coeliac disease pathogenesis: potential molecular mechanisms for other human diseases
    Vittorio Gentile
    Dipartimento di Biochimica e Biofisica, Seconda Universita degli studi di Napoli SUN, Via Costantinopoli 16, 80138, Napoli, Italy
    Neurochem Int 40:79-83. 2002
  2. ncbi Possible physiopathological roles of the transglutaminase activity in the etiopathogenesis of human neurodegenerative diseases
    Federica Titta
    Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Recent Pat CNS Drug Discov 9:101-9. 2014
  3. ncbi Possible physiopathological effects of the transglutaminase activity on the molecular mechanisms responsible for human neurodegenerative diseases
    Martina Iannaccone
    Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Recent Pat CNS Drug Discov 9:76-84. 2014
  4. pmc Possible role of the transglutaminases in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases
    Antonio Martin
    Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Int J Alzheimers Dis 2011:865432. 2011
  5. ncbi Transglutaminase activity as a possible therapeutical target in neurodegenerative diseases
    Martina Iannaccone
    Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Recent Pat CNS Drug Discov 8:235-42. 2013
  6. ncbi Role of the transglutaminase enzymes in the nervous system and their possible involvement in neurodegenerative diseases
    G De Vivo
    Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli 16, 80138, Naples, Italy
    Curr Med Chem 16:4767-73. 2009
  7. ncbi Transglutaminases - possible drug targets in human diseases
    Vittorio Gentile
    Department of Biochemistry and Biophysics, Medical School, Second University of Naples, Naples, Italy
    Curr Drug Targets CNS Neurol Disord 3:99-104. 2004
  8. ncbi Pathophysiological roles of transglutaminase - catalyzed reactions in the pathogenesis of human diseases
    Antonio Martin
    Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli 16, 80138, Naples, Italy
    Inflamm Allergy Drug Targets 11:278-84. 2012
  9. ncbi Role of transglutaminase-catalyzed reactions in the post-translational modifications of proteins responsible for immunological disorders
    Giulia De Vivo
    Department of Biochemistry and Biophysics, Second University of Naples, Naples, Italy
    Inflamm Allergy Drug Targets 7:24-9. 2008
  10. ncbi Transglutaminase inhibition as a possible therapeutical approach to protect cells from death in neurodegenerative diseases
    Martina Iannaccone
    Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy
    Recent Pat CNS Drug Discov 8:161-8. 2013

Collaborators

  • Arthur J L Cooper
  • Thomas M Jeitner
  • Antonio Martin
  • Martina Iannaccone
  • Giulia De Vivo
  • Enrica Serretiello
  • Federica Titta
  • Alessandro Stefanile
  • Mariangela Ricotta
  • Nicola Gaetano Gatta
  • Maura Iannuzzi
  • G De Vivo
  • Giuseppe Amantea
  • Gaetano Cammarota
  • Marco Monfregola
  • Mariarosa A B Melone
  • Carla Sedia
  • Domenico Collaro
  • Alessandro Giuliano
  • R Di Lorenzo
  • M Ricotta
  • Tiziana Trotta
  • Marisa Cammarano
  • Gennaro Romito
  • Lucia Zefferino
  • Mariapina Piccirillo
  • Simone Sampaolo
  • Giuseppe di Fede
  • Giacomo Lus
  • Gianfranco Peluso
  • Roberto Cotrufo
  • Antonio Capasso
  • Giuseppe Di Iorio

Detail Information

Publications18

  1. ncbi Tissue transglutaminase and coeliac disease pathogenesis: potential molecular mechanisms for other human diseases
    Vittorio Gentile
    Dipartimento di Biochimica e Biofisica, Seconda Universita degli studi di Napoli SUN, Via Costantinopoli 16, 80138, Napoli, Italy
    Neurochem Int 40:79-83. 2002
    ..Possible molecular links between CD, neuropsychiatric disorders and biochemical activities of transglutaminase enzymes are discussed...
  2. ncbi Possible physiopathological roles of the transglutaminase activity in the etiopathogenesis of human neurodegenerative diseases
    Federica Titta
    Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Recent Pat CNS Drug Discov 9:101-9. 2014
    ....
  3. ncbi Possible physiopathological effects of the transglutaminase activity on the molecular mechanisms responsible for human neurodegenerative diseases
    Martina Iannaccone
    Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Recent Pat CNS Drug Discov 9:76-84. 2014
    ....
  4. pmc Possible role of the transglutaminases in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases
    Antonio Martin
    Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Int J Alzheimers Dis 2011:865432. 2011
    ....
  5. ncbi Transglutaminase activity as a possible therapeutical target in neurodegenerative diseases
    Martina Iannaccone
    Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Recent Pat CNS Drug Discov 8:235-42. 2013
    ..The article presents some promising patents on the transglutaminase activity. ..
  6. ncbi Role of the transglutaminase enzymes in the nervous system and their possible involvement in neurodegenerative diseases
    G De Vivo
    Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli 16, 80138, Naples, Italy
    Curr Med Chem 16:4767-73. 2009
    ....
  7. ncbi Transglutaminases - possible drug targets in human diseases
    Vittorio Gentile
    Department of Biochemistry and Biophysics, Medical School, Second University of Naples, Naples, Italy
    Curr Drug Targets CNS Neurol Disord 3:99-104. 2004
    ....
  8. ncbi Pathophysiological roles of transglutaminase - catalyzed reactions in the pathogenesis of human diseases
    Antonio Martin
    Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli 16, 80138, Naples, Italy
    Inflamm Allergy Drug Targets 11:278-84. 2012
    ..Possible molecular links between biochemical activities of transglutaminase enzymes, CD and neuropsychiatric disorders are discussed...
  9. ncbi Role of transglutaminase-catalyzed reactions in the post-translational modifications of proteins responsible for immunological disorders
    Giulia De Vivo
    Department of Biochemistry and Biophysics, Second University of Naples, Naples, Italy
    Inflamm Allergy Drug Targets 7:24-9. 2008
    ..In this review we describe the biochemistry of TGs, with particular reference to the molecular mechanisms involved in the physiopathology of this human disease, as a model for the study of other immunological disorders...
  10. ncbi Transglutaminase inhibition as a possible therapeutical approach to protect cells from death in neurodegenerative diseases
    Martina Iannaccone
    Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy
    Recent Pat CNS Drug Discov 8:161-8. 2013
    ..In addition, the review also examines available patents that relates to cysteamine and derivatives. ..
  11. doi Possible involvement of transglutaminase-catalyzed reactions in the physiopathology of neurodegenerative diseases
    Antonio Martin
    Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Amino Acids 44:111-8. 2013
    ....
  12. ncbi Molecular mechanisms responsible for the involvement of tissue transglutaminase in human diseases: Celiac Disease
    Giuseppe Amantea
    Department of Biochemistry and Biophysics, Medical School, Second University of Naples, Naples, Italy
    Front Biosci 11:249-55. 2006
    ..Interestingly, a subset of celiac patients also develops certain neurological disorders. In this review we describe the roles played by tTG in the molecular mechanisms responsible for pathophysiology of Celiac Disease...
  13. pmc Transglutaminase inhibition: A therapy to protect cells from death in neurodegeneration?
    Martina Iannaccone
    Martina Iannaccone, Alessandro Stefanile, Giulia De Vivo, Antonio Martin, Enrica Serretiello, Vittorio Gentile, Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, 80138 Naples, Italy
    World J Biol Chem 3:184-6. 2012
    ..Moreover, therapeutic strategies based on the use of selective or nonselective TG inhibitors for the amelioration of the symptoms of patients with neurological diseases, characterized by aberrant TG activity, are also discussed...
  14. ncbi Transglutaminases as possible therapeutic targets in neurodegenerative diseases
    Antonio Martin
    Department of Biochemistry and Biophysics, Second University of Naples, Naples, Italy
    Recent Pat CNS Drug Discov 5:195-202. 2010
    ....
  15. ncbi Curcumin (Diferulolylmethane) Reduces Transglutaminase 2 Overexpression Induced by Retinoic Acid in Human Nervous Cell Lines
    Nicola Gaetano Gatta
    Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy
    Neuroimmunomodulation 23:188-193. 2016
    ..On the basis of these literature data, our objective was to analyze the effects of curcumin on TG2 expression in human nervous cell lines...
  16. pmc Physio-pathological roles of transglutaminase-catalyzed reactions
    Mariangela Ricotta
    Mariangela Ricotta, Maura Iannuzzi, Giulia De Vivo, Vittorio Gentile, Department of Biochemistry and Biophysics, Medical School, Second University of Naples, Via Costantinopoli 16, 80138 Napoli, Italy
    World J Biol Chem 1:181-7. 2010
    ....
  17. ncbi Abnormal accumulation of tTGase products in muscle and erythrocytes of chorea-acanthocytosis patients
    Mariarosa A B Melone
    Department of Neurological Sciences, Second University of Naples School of Medicine, Policlinico Universitario Federico II, Italy
    J Neuropathol Exp Neurol 61:841-8. 2002
    ..These findings could explain the mechanisms underlying the increased blood levels of creatine kinase and acanthocytosis, which are the most consistent features of this neurodegenerative disease...
  18. ncbi Cross linking of polyglutamine domains catalyzed by tissue transglutaminase is greatly favored with pathological-length repeats: does transglutaminase activity play a role in (CAG)(n)/Q(n)-expansion diseases?
    Arthur J L Cooper
    Department of Biochemistry, Weill Medical College of Cornell University, New York, NY, USA
    Neurochem Int 40:53-67. 2002
    ..At first the proteasome machinery can recognize and degrade the cross-linked proteins, but over time the proteasome machinery may be overwhelmed and protein aggregates will accumulate...