Research Topics
Species | Gennaro GaliziaSummaryAffiliation: Second University of Naples Country: Italy Publications
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Publications
The Over-The-Scope-Clip (OTSC) system is effective in the treatment of chronic esophagojejunal anastomotic leakageGennaro Galizia
Division of Surgical Oncology F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, c o II Policlinico, Edificio 17, Via Pansini 5, 80131 Naples, Italy
J Gastrointest Surg 16:1585-9. 2012..The Over-The-Scope-Clip (OTSC) system has been shown to be appropriate to close acute small gastrointestinal perforations, but its use in the treatment of chronic leakage remains controversial...
[Biliary ileus: a review of the literature and report of a clinical case treated by minilaparotomy]G Galizia
VII Divisione di Chirurgia Generale ed Epatobiliare, Facolta di Medicina e Chirurgia, Seconda Universita di Napoli
Ann Ital Chir 71:483-8; discussion 488-9. 2000..To evaluate the diagnostic and therapeutic approach to gallstone ileus...- Prognostic value of p27, p53, and vascular endothelial growth factor in Dukes A and B colon cancer patients undergoing potentially curative surgeryGennaro Galizia
Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
Dis Colon Rectum 47:1904-14. 2004..However, 20 percent to 30 percent of these patients ultimately succumb from recurrent disease. This indicates that the conventional staging procedures may be unable to precisely predict cancer prognosis... - p27 downregulation and metallothionein overexpression in gastric cancer patients are associated with a poor survival rateGennaro Galizia
Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
J Surg Oncol 93:241-52. 2006.... - Prognostic significance of epidermal growth factor receptor expression in colon cancer patients undergoing curative surgeryGennaro Galizia
Division of Surgical Oncology, F Magrassi and A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, 80131, Italy
Ann Surg Oncol 13:823-35. 2006..To investigate the role of epidermal growth factor receptor (EGFR) expression as a prognostic marker for prediction of cancer behavior and clinical outcomes in colon cancer patients undergoing potentially curative surgery... - Epidermal growth factor receptor (EGFR) expression is associated with a worse prognosis in gastric cancer patients undergoing curative surgeryGennaro Galizia
Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, c o II Policlinico, Edificio 17, Via Pansini, Naples, Italy
World J Surg 31:1458-68. 2007.... - Cetuximab, a chimeric human mouse anti-epidermal growth factor receptor monoclonal antibody, in the treatment of human colorectal cancerG Galizia
Division of Surgery, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Medical and Surgical Oncology and Clinical Immunology, Second University of Naples School of Medicine, Naples, Italy
Oncogene 26:3654-60. 2007..Furthermore, a series of phase III clinical trials are currently evaluating the combination of cetuximab with standard chemotherapy regimens in the first-line treatment chemotherapy-naïve patients with metastatic CRC... - The lymph node ratio is a powerful prognostic factor of node-positive colon cancers undergoing potentially curative surgeryGennaro Galizia
Division of Surgical Oncology, F Magrassi, A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, 80131 Naples, Italy
World J Surg 33:2704-13. 2009..This study investigated LNR as a prognostic factor in node-positive colon cancers... - First-line chemotherapy vs bowel tumor resection plus chemotherapy for patients with unresectable synchronous colorectal hepatic metastasesGennaro Galizia
Second University of Naples School of Medicine, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, c o II Policlinico, Edificio 17, Via Pansini, 5, 80131 Naples, Italy
Arch Surg 143:352-8; discussion 358. 2008..Bowel resection followed by chemotherapy is a better management strategy than immediate chemotherapy in asymptomatic patients with colorectal cancer and unresectable liver-only metastases at presentation... - Determination of molecular marker expression can predict clinical outcome in colon carcinomasGennaro Galizia
Division of Surgical Oncology, Second University of Naples School of Medicine, Naples, Italy
Clin Cancer Res 10:3490-9. 2004..involved in cell cycle regulation (p27 and p53), apoptosis (p53 and p27), and tumor neoangiogenesis [p53, vascular endothelial growth factor (VEGF), and microvessel count] in predicting tumor behavior and clinical outcome in CRC patients.. - Hemodynamic and pulmonary changes during open, carbon dioxide pneumoperitoneum and abdominal wall-lifting cholecystectomy. A prospective, randomized studyG Galizia
Department of Surgical Sciences, General and Hepato Biliary Surgery Unit, Second University of Naples School of Medicine, c o II Policlinico, Ed 17, Via S Pansini, 5, 80131 Naples, Italy
Surg Endosc 15:477-83. 2001..Carbon dioxide (CO2) pneumoperitoneum effects are still controversial. The aim of this study was to investigate cardiopulmonary changes in patients subjected to different surgical procedures for cholecystectomy... - Circulating levels of interleukin-10 and interleukin-6 in gastric and colon cancer patients before and after surgery: relationship with radicality and outcomeGennaro Galizia
Division of Surgical Oncology, F Magrassi and A Lanzara Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Naples, Italy
J Interferon Cytokine Res 22:473-82. 2002..Abnormally high postoperative IL-10 values negatively affected disease-free survival and tumor recurrence. IL-6 serum levels were found to have a more limited prognostic role... - Combined CD133/CD44 expression as a prognostic indicator of disease-free survival in patients with colorectal cancerGennaro Galizia
Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery F Magrassi A Lanzara, Second University of Naples School of Medicine, c o II Policlinico, Edificio 17, 5 Via Pansini, 80131 Naples, Italy
Arch Surg 147:18-24. 2012..CD133 and CD44 are commonly used as CSC markers, and correlation of their expression with colorectal cancer (CRC) clinicopathological features and outcomes may be useful... - A true splenic cyst producing carbohydrate antigen 19-9 and cancer antigens 50 and 125, but not interleukin 10Gennaro Galizia
Department of Clinical and Experimental Medicine, 2nd University of Naples School of Medicine, Naples, Italy
Dig Surg 20:71-4. 2003..In addition, normal serum values of interleukin 10 correctly predicted the benign nature of the lesion... - Weekly chemotherapy with cisplatin and paclitaxel and concurrent radiation therapy as preoperative treatment in locally advanced esophageal cancer: a phase II studyMichele Orditura
Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery F Magrassi e A Lanzara, Second University of Naples, School of Medicine, Naples, Italy
Cancer Invest 28:820-7. 2010..The EUS maximal transverse cross sectional area reduction >50% significantly correlated with pathCR. Three-year survival rate was 35%. These results support the activity and mild toxicity of this regimen... - Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patientsEva Lieto
Divisions of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, c o II Policlinico, Edificio 17, Via Pansini, 5, 80131, Naples, Italy
Ann Surg Oncol 15:69-79. 2008.... - Perspectives in adjuvant therapy of gastric cancerFerdinando De Vita
Medical Oncology, Department of Clinical and Experimental Medicine F Magrassi and A Lanzara, Second University of Naples, Naples, Italy
Oncology 77:38-42. 2009..Therefore, at present the routine use of adjuvant therapy should be regarded as an investigational approach. Improved clinical trial designs with standardized surgical techniques and the incorporation of newer active drugs are needed... - Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgeryGennaro Galizia
Division of Surgical Oncology, F. Magrassi and A. Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
Clin Immunol 102:169-78. 2002..6 and 96%, respectively). IL-6 serum levels were found to have a more limited prognostic role... - Elevated perioperative serum vascular endothelial growth factor levels in patients with colon carcinomaFerdinando De Vita
Division of Medical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, II Policlinico, Via S Pansini 5, 90131 Naples, Italy
Cancer 100:270-8. 2004.... - Adjuvant chemoradiotherapy in patients with stage III or IV radically resected gastric cancer: a pilot studyMichele Orditura
Division of Medical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, c o II Policlinico, Via Pansini 5, Naples, Italy
Arch Surg 145:233-8. 2010..We assessed the feasibility and toxic effects of chemoradiotherapy as adjuvant treatment in locally advanced gastric cancer... - Normal interleukin-10 serum level opposed to high serum levels of carbohydrate antigen 19-9 and cancer antigens 125 and 50 in a case of true splenic cystEva Lieto
Division of Surgical Oncology, F. Magrassi and A. Lanzara Department of Clinical and Experimental Medicine, School of Medicine, Second University of Naples, Naples, Italy
Arch Med Res 34:145-8. 2003..When malignant disease is suspected, IL-10 serum level could be useful to correctly predict the nature of the lesion... - Behavior of circulating CD4+CD25+Foxp3+ regulatory T cells in colon cancer patients undergoing surgeryAusilia Sellitto
Division of Internal Medicine, Allergy and Clinical Immunology, Department of Medicine, Second University of Naples, Piazza Miraglia, 3, 80138, Naples, Italy
J Clin Immunol 31:1095-104. 2011..Of note, nonradically resected patients were found to display reductions in-but not normalization of-Treg frequencies. These results suggest that cancer itself may be able to drive Treg recruitment as a strategy of immunoevasion... 
Hepatoid carcinoma colliding with a liposarcoma of the left colon serosa presenting as an abdominal massMichele Orditura
Cattedra di Oncologia Medica, Seconda Università degli Studi di Napoli Ospedale Da Procida, Salerno, Naples, Italy
World J Surg Oncol 5:42. 2007..Stomach is the most frequent site where hepatoid adenocarcinoma occurs, although it has been described in many other organs. On the other side, liposarcoma is a rare, malignant tumor that develops from fat cells...- Elevated serum levels of interleukin-8 in advanced non-small cell lung cancer patients: relationship with prognosisMichele Orditura
Division of Medical Oncology, F Magrassi Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Naples, Italy
J Interferon Cytokine Res 22:1129-35. 2002..In conclusion, this study showed that IL-8 serum levels were elevated in advanced NSCLC patients and correlated with both OS and TTF, but they were shown not to be an independent prognostic factor... - Endoscopic intraoperative anastomotic testing may avoid early gastrointestinal anastomotic complications. A prospective studyEva Lieto
Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, 80131 Naples, Italy
J Gastrointest Surg 15:145-52. 2011..Since endoscopic intraoperative anastomotic testing allows direct visualization of anastomosis, complication rates may be theoretically reduced by the use of this technique... - Correlation between efficacy and skin rash occurrence following treatment with the epidermal growth factor receptor inhibitor cetuximab: a single institution retrospective analysisMichele Orditura
Division of Medical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, c o II Policlinico, 80131 Naples, Italy
Oncol Rep 21:1023-8. 2009..Skin toxicity was confirmed as the only clinical variable able to predict the response to cetuximab... - Radiofrequency-assisted liver resection with a comb-shaped bipolar device versus clamp crushing: a clinical studyGennaro Galizia
1Second University of Naples, Naples, Italy
Surg Innov 19:407-14. 2012..Conclusion. Compared with the CC procedure, this bipolar device was shown to be safe and effective in liver resections, allowing a very clean surgical field without increase of postoperative complications... - Dufourmentel rhomboid flap in the radical treatment of primary and recurrent sacrococcygeal pilonidal diseaseEva Lieto
Second Department of General Surgery, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
Dis Colon Rectum 53:1061-8. 2010..The aim of this study was to assess early and late results of the Dufourmentel procedure in patients with primary and recurrent sacrococcygeal pilonidal disease... - Current status of targeted therapies in advanced gastric cancerFerdinando De Vita
Oncologia Medica, Seconda Universita di Napoli, Via S Pansini 5, 80131, Napoli, Italia
Expert Opin Ther Targets 16:S29-34. 2012..This means that accurate HER2 testing in gastric cancer is necessary. Final data of ongoing trials with novel agents will be critical to further progress with this cancer... - Preoperative chemoradiotherapy for squamous cell carcinoma and adenocarcinoma of the esophagus: a phase II studyFerdinando De Vita
Division of Medical Oncology, F. Magrassi Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Via Pansini 5, 80131 Naples, Italy
Chest 122:1302-8. 2002..Despite the small number of patients in the series and the inclusion of patients with different histotypes, we concluded that patients with the squamous histotype show a better outcome than those with adenocarcinoma... - Cetuximab in the treatment of colorectal cancerFortunato Ciardiello
Seconda Universita degli Studi di Napoli, Cattedra di Oncologia Medica, Dipartimento Medico Chirurgico di Internistica Clinica Sperimentale F Magrassi e A Lanzara, Via S Pansini 5, 80131 Napoli, Italy
Future Oncol 1:173-81. 2005.... - Chemoradiotherapy as adjuvant treatment of gastric cancerM Orditura
Department of Medical Oncology, F Magrassi and A Lanzara, Second University of Naples School of Medicine, Naple, Italy
Ann Oncol 18:vi133-5. 2007..However, many questions remain to evaluate; first of all the toxicity of this approach and its efficacy after adequate surgery... - Interleukin-6 serum level correlates with survival in advanced gastrointestinal cancer patients but is not an independent prognostic indicatorF De Vita
Division of Internal Medicine, F Magrassi Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Naples, Italy
J Interferon Cytokine Res 21:45-52. 2001..In conclusion, this study showed that IL-6 serum levels were elevated in advanced gastrointestinal cancer patients and correlated with both OS and TTP. However, they were shown not to be an independent prognostic factor... - Weekly docetaxel and capecitabine is not effective in the treatment of advanced gastric cancer: a phase II studyM Orditura
Dipartimento Medico Chirurgico di Internistica Clinica e Sperimentale 'F Magrassi e A Lanzara Cattedra di Oncologia Medica, Naples, Italy
Ann Oncol 17:1529-32. 2006..CONCLUSIONS: The combination of docetaxel and capecitabine at the doses and schedule investigated in this study is safe, but does not show significant activity in untreated patients with advanced gastric cancer... 
A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FOLFOX-4) as first-line treatment of advanced gastric cancer patientsF De Vita
Division of Medical Oncology, F Magrassi and A Lanzara Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Naples, Italy
Br J Cancer 92:1644-9. 2005..FOLFOX-4 is an active and well-tolerated chemotherapy. Response rate (RR), TTP and OS were comparable with those of other oxaliplatin-based regimens, suggesting a role for this combination in gastric cancer...- Neo-adjuvant and adjuvant chemotherapy of gastric cancerF De Vita
Division of Medical Oncology, Surgical Oncology, F Magrassi and A Lanzara, Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Naples, Italy
Ann Oncol 18:vi120-3. 2007..On the contrary, neo-adjuvant chemotherapy has shown promising results as suggested by the final results of UK Medical Research Council Adjuvant Gastric Infusional Chemotherapy trial... - Behaviour of interleukin-2 serum levels in advanced non-small-cell lung cancer patients: relationship with response to therapy and survivalM Orditura
F Magrassi Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Italy
Cancer Immunol Immunother 49:530-6. 2000..In conclusion, determination of pre-treatment IL-2 serum levels was shown to be of independent prognostic utility in patients with advanced NSCLC; therefore, its possible use for prediction of outcome is proposed... - Counting alleles to predict recurrence of early-stage colorectal cancersWei Zhou
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Lancet 359:219-25. 2002..002). INTERPRETATION: In patients without metastasis, allelic imbalance is a better predictor of prognosis than histopathological stage... - Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patientsTian Li Wang
The Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center and Department of Surgery, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 101:3089-94. 2004..01). These data suggest that genetic amplification of TYMS is a major mechanism of 5-FU resistance in vivo and have important implications for the management of colorectal cancer patients with recurrent disease...