Gennaro Galizia

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. ncbi request reprint Prognostic value of p27, p53, and vascular endothelial growth factor in Dukes A and B colon cancer patients undergoing potentially curative surgery
    Gennaro Galizia
    Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
    Dis Colon Rectum 47:1904-14. 2004
  2. doi request reprint Is complete mesocolic excision with central vascular ligation safe and effective in the surgical treatment of right-sided colon cancers? A prospective study
    Gennaro Galizia
    Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, School of Medicine, Second University of Naples, c o II Policlinico, Edificio 17 Via Pansini, 5, 80131, Naples, Italy
    Int J Colorectal Dis 29:89-97. 2014
  3. doi request reprint Postoperative detection of circulating tumor cells predicts tumor recurrence in colorectal cancer patients
    Gennaro Galizia
    Division of Surgical Oncology F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, c o II Policlinico, Edificio 17, Via Pansini 5, 80131, Naples, Italy
    J Gastrointest Surg 17:1809-18. 2013
  4. doi request reprint Radiofrequency-assisted liver resection with a comb-shaped bipolar device versus clamp crushing: a clinical study
    Gennaro Galizia
    Second University of Naples School of Medicine, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, c o II Policlinico, Edificio 17, Via Pansini 5, 80131 Naples, Italy
    Surg Innov 19:407-14. 2012
  5. doi request reprint The Over-The-Scope-Clip (OTSC) system is effective in the treatment of chronic esophagojejunal anastomotic leakage
    Gennaro Galizia
    Division of Surgical Oncology F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, c o II Policlinico, Edificio 17, Via Pansini 5, 80131 Naples, Italy
    J Gastrointest Surg 16:1585-9. 2012
  6. ncbi request reprint Determination of molecular marker expression can predict clinical outcome in colon carcinomas
    Gennaro Galizia
    Division of Surgical Oncology, Second University of Naples School of Medicine, Naples, Italy
    Clin Cancer Res 10:3490-9. 2004
  7. ncbi request reprint p27 downregulation and metallothionein overexpression in gastric cancer patients are associated with a poor survival rate
    Gennaro Galizia
    Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
    J Surg Oncol 93:241-52. 2006
  8. ncbi request reprint Cetuximab, a chimeric human mouse anti-epidermal growth factor receptor monoclonal antibody, in the treatment of human colorectal cancer
    G Galizia
    Division of Surgery, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Medical and Surgical Oncology and Clinical Immunology, Second University of Naples School of Medicine, Naples, Italy
    Oncogene 26:3654-60. 2007
  9. ncbi request reprint Prognostic significance of epidermal growth factor receptor expression in colon cancer patients undergoing curative surgery
    Gennaro Galizia
    Division of Surgical Oncology, F Magrassi and A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, 80131, Italy
    Ann Surg Oncol 13:823-35. 2006
  10. ncbi request reprint Epidermal growth factor receptor (EGFR) expression is associated with a worse prognosis in gastric cancer patients undergoing curative surgery
    Gennaro Galizia
    Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, c o II Policlinico, Edificio 17, Via Pansini, Naples, Italy
    World J Surg 31:1458-68. 2007

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Prognostic value of p27, p53, and vascular endothelial growth factor in Dukes A and B colon cancer patients undergoing potentially curative surgery
    Gennaro Galizia
    Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
    Dis Colon Rectum 47:1904-14. 2004
    ..However, 20 percent to 30 percent of these patients ultimately succumb from recurrent disease. This indicates that the conventional staging procedures may be unable to precisely predict cancer prognosis...
  2. doi request reprint Is complete mesocolic excision with central vascular ligation safe and effective in the surgical treatment of right-sided colon cancers? A prospective study
    Gennaro Galizia
    Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, School of Medicine, Second University of Naples, c o II Policlinico, Edificio 17 Via Pansini, 5, 80131, Naples, Italy
    Int J Colorectal Dis 29:89-97. 2014
    ..Impressive outcomes have been reported, however, direct comparisons with the classic procedure are lacking...
  3. doi request reprint Postoperative detection of circulating tumor cells predicts tumor recurrence in colorectal cancer patients
    Gennaro Galizia
    Division of Surgical Oncology F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, c o II Policlinico, Edificio 17, Via Pansini 5, 80131, Naples, Italy
    J Gastrointest Surg 17:1809-18. 2013
    ..Circulating tumor cells are thought to play a crucial role in the development of distant metastases. Their detection in the blood of colorectal cancer patients may be linked to poor outcome, but current evidence is controversial...
  4. doi request reprint Radiofrequency-assisted liver resection with a comb-shaped bipolar device versus clamp crushing: a clinical study
    Gennaro Galizia
    Second University of Naples School of Medicine, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, c o II Policlinico, Edificio 17, Via Pansini 5, 80131 Naples, Italy
    Surg Innov 19:407-14. 2012
    ..Recently, it has been suggested that radiofrequency-assisted liver resection (RFALR) may be more advantageous, but sufficient evidence has yet to be accumulated...
  5. doi request reprint The Over-The-Scope-Clip (OTSC) system is effective in the treatment of chronic esophagojejunal anastomotic leakage
    Gennaro Galizia
    Division of Surgical Oncology F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, c o II Policlinico, Edificio 17, Via Pansini 5, 80131 Naples, Italy
    J Gastrointest Surg 16:1585-9. 2012
    ..The Over-The-Scope-Clip (OTSC) system has been shown to be appropriate to close acute small gastrointestinal perforations, but its use in the treatment of chronic leakage remains controversial...
  6. ncbi request reprint Determination of molecular marker expression can predict clinical outcome in colon carcinomas
    Gennaro Galizia
    Division of Surgical Oncology, Second University of Naples School of Medicine, Naples, Italy
    Clin Cancer Res 10:3490-9. 2004
    ..involved in cell cycle regulation (p27 and p53), apoptosis (p53 and p27), and tumor neoangiogenesis [p53, vascular endothelial growth factor (VEGF), and microvessel count] in predicting tumor behavior and clinical outcome in CRC patients..
  7. ncbi request reprint p27 downregulation and metallothionein overexpression in gastric cancer patients are associated with a poor survival rate
    Gennaro Galizia
    Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
    J Surg Oncol 93:241-52. 2006
    ....
  8. ncbi request reprint Cetuximab, a chimeric human mouse anti-epidermal growth factor receptor monoclonal antibody, in the treatment of human colorectal cancer
    G Galizia
    Division of Surgery, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Medical and Surgical Oncology and Clinical Immunology, Second University of Naples School of Medicine, Naples, Italy
    Oncogene 26:3654-60. 2007
    ..Furthermore, a series of phase III clinical trials are currently evaluating the combination of cetuximab with standard chemotherapy regimens in the first-line treatment chemotherapy-naïve patients with metastatic CRC...
  9. ncbi request reprint Prognostic significance of epidermal growth factor receptor expression in colon cancer patients undergoing curative surgery
    Gennaro Galizia
    Division of Surgical Oncology, F Magrassi and A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, 80131, Italy
    Ann Surg Oncol 13:823-35. 2006
    ..To investigate the role of epidermal growth factor receptor (EGFR) expression as a prognostic marker for prediction of cancer behavior and clinical outcomes in colon cancer patients undergoing potentially curative surgery...
  10. ncbi request reprint Epidermal growth factor receptor (EGFR) expression is associated with a worse prognosis in gastric cancer patients undergoing curative surgery
    Gennaro Galizia
    Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, c o II Policlinico, Edificio 17, Via Pansini, Naples, Italy
    World J Surg 31:1458-68. 2007
    ....
  11. doi request reprint The lymph node ratio is a powerful prognostic factor of node-positive colon cancers undergoing potentially curative surgery
    Gennaro Galizia
    Division of Surgical Oncology, F Magrassi, A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, 80131 Naples, Italy
    World J Surg 33:2704-13. 2009
    ..This study investigated LNR as a prognostic factor in node-positive colon cancers...
  12. doi request reprint First-line chemotherapy vs bowel tumor resection plus chemotherapy for patients with unresectable synchronous colorectal hepatic metastases
    Gennaro Galizia
    Second University of Naples School of Medicine, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, c o II Policlinico, Edificio 17, Via Pansini, 5, 80131 Naples, Italy
    Arch Surg 143:352-8; discussion 358. 2008
    ..Bowel resection followed by chemotherapy is a better management strategy than immediate chemotherapy in asymptomatic patients with colorectal cancer and unresectable liver-only metastases at presentation...
  13. ncbi request reprint [Biliary ileus: a review of the literature and report of a clinical case treated by minilaparotomy]
    G Galizia
    VII Divisione di Chirurgia Generale ed Epatobiliare, Facolta di Medicina e Chirurgia, Seconda Universita di Napoli
    Ann Ital Chir 71:483-8; discussion 488-9. 2000
    ..To evaluate the diagnostic and therapeutic approach to gallstone ileus...
  14. ncbi request reprint Hemodynamic and pulmonary changes during open, carbon dioxide pneumoperitoneum and abdominal wall-lifting cholecystectomy. A prospective, randomized study
    G Galizia
    Department of Surgical Sciences, General and Hepato Biliary Surgery Unit, Second University of Naples School of Medicine, c o II Policlinico, Ed 17, Via S Pansini, 5, 80131 Naples, Italy
    Surg Endosc 15:477-83. 2001
    ..Carbon dioxide (CO2) pneumoperitoneum effects are still controversial. The aim of this study was to investigate cardiopulmonary changes in patients subjected to different surgical procedures for cholecystectomy...
  15. ncbi request reprint A true splenic cyst producing carbohydrate antigen 19-9 and cancer antigens 50 and 125, but not interleukin 10
    Gennaro Galizia
    Department of Clinical and Experimental Medicine, 2nd University of Naples School of Medicine, Naples, Italy
    Dig Surg 20:71-4. 2003
    ..In addition, normal serum values of interleukin 10 correctly predicted the benign nature of the lesion...
  16. doi request reprint Combined CD133/CD44 expression as a prognostic indicator of disease-free survival in patients with colorectal cancer
    Gennaro Galizia
    Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery F Magrassi A Lanzara, Second University of Naples School of Medicine, c o II Policlinico, Edificio 17, 5 Via Pansini, 80131 Naples, Italy
    Arch Surg 147:18-24. 2012
    ..CD133 and CD44 are commonly used as CSC markers, and correlation of their expression with colorectal cancer (CRC) clinicopathological features and outcomes may be useful...
  17. ncbi request reprint Circulating levels of interleukin-10 and interleukin-6 in gastric and colon cancer patients before and after surgery: relationship with radicality and outcome
    Gennaro Galizia
    Division of Surgical Oncology, F Magrassi and A Lanzara Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Naples, Italy
    J Interferon Cytokine Res 22:473-82. 2002
    ..Abnormally high postoperative IL-10 values negatively affected disease-free survival and tumor recurrence. IL-6 serum levels were found to have a more limited prognostic role...
  18. ncbi request reprint Conversion chemotherapy followed by hepatic resection in colorectal cancer with initially unresectable liver-limited metastases
    Gennaro Galizia
    Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
    Oncol Rep 30:2992-8. 2013
    ..Prospective randomized trials are required to define the conversion rates with biological drugs...
  19. doi request reprint Weekly chemotherapy with cisplatin and paclitaxel and concurrent radiation therapy as preoperative treatment in locally advanced esophageal cancer: a phase II study
    Michele Orditura
    Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery F Magrassi e A Lanzara, Second University of Naples, School of Medicine, Naples, Italy
    Cancer Invest 28:820-7. 2010
    ..The EUS maximal transverse cross sectional area reduction >50% significantly correlated with pathCR. Three-year survival rate was 35%. These results support the activity and mild toxicity of this regimen...
  20. ncbi request reprint Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients
    Eva Lieto
    Divisions of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, c o II Policlinico, Edificio 17, Via Pansini, 5, 80131, Naples, Italy
    Ann Surg Oncol 15:69-79. 2008
    ....
  21. doi request reprint Perspectives in adjuvant therapy of gastric cancer
    Ferdinando De Vita
    Medical Oncology, Department of Clinical and Experimental Medicine F Magrassi and A Lanzara, Second University of Naples, Naples, Italy
    Oncology 77:38-42. 2009
    ..Therefore, at present the routine use of adjuvant therapy should be regarded as an investigational approach. Improved clinical trial designs with standardized surgical techniques and the incorporation of newer active drugs are needed...
  22. ncbi request reprint Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery
    Gennaro Galizia
    Division of Surgical Oncology, F Magrassi and A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
    Clin Immunol 102:169-78. 2002
    ..6 and 96%, respectively). IL-6 serum levels were found to have a more limited prognostic role...
  23. ncbi request reprint Elevated perioperative serum vascular endothelial growth factor levels in patients with colon carcinoma
    Ferdinando De Vita
    Division of Medical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, II Policlinico, Via S Pansini 5, 90131 Naples, Italy
    Cancer 100:270-8. 2004
    ....
  24. doi request reprint Adjuvant chemoradiotherapy in patients with stage III or IV radically resected gastric cancer: a pilot study
    Michele Orditura
    Division of Medical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, c o II Policlinico, Via Pansini 5, Naples, Italy
    Arch Surg 145:233-8. 2010
    ..We assessed the feasibility and toxic effects of chemoradiotherapy as adjuvant treatment in locally advanced gastric cancer...
  25. ncbi request reprint Normal interleukin-10 serum level opposed to high serum levels of carbohydrate antigen 19-9 and cancer antigens 125 and 50 in a case of true splenic cyst
    Eva Lieto
    Division of Surgical Oncology, F Magrassi and A Lanzara Department of Clinical and Experimental Medicine, School of Medicine, Second University of Naples, Naples, Italy
    Arch Med Res 34:145-8. 2003
    ..When malignant disease is suspected, IL-10 serum level could be useful to correctly predict the nature of the lesion...
  26. doi request reprint CD66c is a novel marker for colorectal cancer stem cell isolation, and its silencing halts tumor growth in vivo
    Marica Gemei
    CEINGE Advanced Biotechnology, Naples, Italy
    Cancer 119:729-38. 2013
    ....
  27. doi request reprint Behavior of circulating CD4+CD25+Foxp3+ regulatory T cells in colon cancer patients undergoing surgery
    Ausilia Sellitto
    Division of Internal Medicine, Allergy and Clinical Immunology, Department of Medicine, Second University of Naples, Piazza Miraglia, 3, 80138, Naples, Italy
    J Clin Immunol 31:1095-104. 2011
    ..Of note, nonradically resected patients were found to display reductions in-but not normalization of-Treg frequencies. These results suggest that cancer itself may be able to drive Treg recruitment as a strategy of immunoevasion...
  28. pmc Hepatoid carcinoma colliding with a liposarcoma of the left colon serosa presenting as an abdominal mass
    Michele Orditura
    Cattedra di Oncologia Medica, Seconda Università degli Studi di Napoli Ospedale Da Procida, Salerno, Naples, Italy
    World J Surg Oncol 5:42. 2007
    ..Stomach is the most frequent site where hepatoid adenocarcinoma occurs, although it has been described in many other organs. On the other side, liposarcoma is a rare, malignant tumor that develops from fat cells...
  29. ncbi request reprint Elevated serum levels of interleukin-8 in advanced non-small cell lung cancer patients: relationship with prognosis
    Michele Orditura
    Division of Medical Oncology, F Magrassi Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Naples, Italy
    J Interferon Cytokine Res 22:1129-35. 2002
    ..In conclusion, this study showed that IL-8 serum levels were elevated in advanced NSCLC patients and correlated with both OS and TTF, but they were shown not to be an independent prognostic factor...
  30. doi request reprint Endoscopic intraoperative anastomotic testing may avoid early gastrointestinal anastomotic complications. A prospective study
    Eva Lieto
    Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, 80131 Naples, Italy
    J Gastrointest Surg 15:145-52. 2011
    ..Since endoscopic intraoperative anastomotic testing allows direct visualization of anastomosis, complication rates may be theoretically reduced by the use of this technique...
  31. ncbi request reprint Correlation between efficacy and skin rash occurrence following treatment with the epidermal growth factor receptor inhibitor cetuximab: a single institution retrospective analysis
    Michele Orditura
    Division of Medical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, c o II Policlinico, 80131 Naples, Italy
    Oncol Rep 21:1023-8. 2009
    ..Skin toxicity was confirmed as the only clinical variable able to predict the response to cetuximab...
  32. ncbi request reprint Dufourmentel rhomboid flap in the radical treatment of primary and recurrent sacrococcygeal pilonidal disease
    Eva Lieto
    Second Department of General Surgery, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
    Dis Colon Rectum 53:1061-8. 2010
    ..The aim of this study was to assess early and late results of the Dufourmentel procedure in patients with primary and recurrent sacrococcygeal pilonidal disease...
  33. doi request reprint Preoperative treatment of locally advanced esophageal carcinoma (Review)
    Michele Orditura
    Division of Medical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, School of Medicine, Naples, Italy
    Int J Oncol 43:1745-53. 2013
    ..Addition of drugs targeting VEGF or HER2 to standard chemotherapy appears to be feasible but needs to be explored more accurately. FDG-PET may predict both response to neoadjuvant treatments and prognosis...
  34. doi request reprint Current status of targeted therapies in advanced gastric cancer
    Ferdinando De Vita
    Oncologia Medica, Seconda Universita di Napoli, Via S Pansini 5, 80131, Napoli, Italia
    Expert Opin Ther Targets 16:S29-34. 2012
    ..However, even after the use of more effective regimens, the overall survival remains disappointing, justifying the need for new treatment options...
  35. pmc Treatment of gastric cancer
    Michele Orditura
    Michele Orditura, Vincenzo Sforza, Valentina Gambardella, Alessio Fabozzi, Maria Maddalena Laterza, Francesca Andreozzi, Jole Ventriglia, Beatrice Savastano, Fortunato Ciardiello, Ferdinando De Vita, Division of Medical Oncology, Dipartimento di Medicina, Clinica e Sperimentale F Magrassi A Lanzara, Seconda Universita degli Studi di Napoli, 80131 Naples, Italy
    World J Gastroenterol 20:1635-49. 2014
    ..Recent evidence supports the use of second-line chemotherapy after progression in patients with good performance status. ..
  36. ncbi request reprint Preoperative chemoradiotherapy for squamous cell carcinoma and adenocarcinoma of the esophagus: a phase II study
    Ferdinando De Vita
    Division of Medical Oncology, F Magrassi Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Via Pansini 5, 80131 Naples, Italy
    Chest 122:1302-8. 2002
    ..The main end points were to determine the resectability of the tumor and the pathologic tumor response. An accessory aim was to evaluate the survival rate...
  37. ncbi request reprint Cetuximab in the treatment of colorectal cancer
    Fortunato Ciardiello
    Seconda Universita degli Studi di Napoli, Cattedra di Oncologia Medica, Dipartimento Medico Chirurgico di Internistica Clinica Sperimentale F Magrassi e A Lanzara, Via S Pansini 5, 80131 Napoli, Italy
    Future Oncol 1:173-81. 2005
    ....
  38. ncbi request reprint Chemoradiotherapy as adjuvant treatment of gastric cancer
    M Orditura
    Department of Medical Oncology, F Magrassi and A Lanzara, Second University of Naples School of Medicine, Naple, Italy
    Ann Oncol 18:vi133-5. 2007
    ..However, many questions remain to evaluate; first of all the toxicity of this approach and its efficacy after adequate surgery...
  39. pmc A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FOLFOX-4) as first-line treatment of advanced gastric cancer patients
    F De Vita
    Division of Medical Oncology, F Magrassi and A Lanzara Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Naples, Italy
    Br J Cancer 92:1644-9. 2005
    ..FOLFOX-4 is an active and well-tolerated chemotherapy. Response rate (RR), TTP and OS were comparable with those of other oxaliplatin-based regimens, suggesting a role for this combination in gastric cancer...
  40. ncbi request reprint Weekly docetaxel and capecitabine is not effective in the treatment of advanced gastric cancer: a phase II study
    M Orditura
    Dipartimento Medico Chirurgico di Internistica Clinica e Sperimentale F Magrassi e A Lanzara Cattedra di Oncologia Medica, Naples, Italy
    Ann Oncol 17:1529-32. 2006
    ..We assessed the clinical activity and the toxicity of weekly docetaxel in combination with capecitabine in untreated patients with advanced gastric cancer...
  41. ncbi request reprint Interleukin-6 serum level correlates with survival in advanced gastrointestinal cancer patients but is not an independent prognostic indicator
    F De Vita
    Division of Internal Medicine, F Magrassi Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Naples, Italy
    J Interferon Cytokine Res 21:45-52. 2001
    ..In conclusion, this study showed that IL-6 serum levels were elevated in advanced gastrointestinal cancer patients and correlated with both OS and TTP. However, they were shown not to be an independent prognostic factor...
  42. ncbi request reprint Neo-adjuvant and adjuvant chemotherapy of gastric cancer
    F De Vita
    Division of Medical Oncology, Surgical Oncology, F Magrassi and A Lanzara, Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Naples, Italy
    Ann Oncol 18:vi120-3. 2007
    ..On the contrary, neo-adjuvant chemotherapy has shown promising results as suggested by the final results of UK Medical Research Council Adjuvant Gastric Infusional Chemotherapy trial...
  43. ncbi request reprint Behaviour of interleukin-2 serum levels in advanced non-small-cell lung cancer patients: relationship with response to therapy and survival
    M Orditura
    F Magrassi Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Italy
    Cancer Immunol Immunother 49:530-6. 2000
    ..In conclusion, determination of pre-treatment IL-2 serum levels was shown to be of independent prognostic utility in patients with advanced NSCLC; therefore, its possible use for prediction of outcome is proposed...
  44. ncbi request reprint Counting alleles to predict recurrence of early-stage colorectal cancers
    Wei Zhou
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Lancet 359:219-25. 2002
    ..However, measurements of such imbalances are difficult. We used a new, quantitative approach to investigate the prognostic value of chromosome imbalances in early-stage colorectal cancers...
  45. pmc Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients
    Tian Li Wang
    The Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center and Department of Surgery, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 101:3089-94. 2004
    ..01). These data suggest that genetic amplification of TYMS is a major mechanism of 5-FU resistance in vivo and have important implications for the management of colorectal cancer patients with recurrent disease...