Rosanna Filosa

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. Di Mola A, Peduto A, La Gatta A, Delang L, Pastorino B, Neyts J, et al. Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication. Bioorg Med Chem. 2014;22:6014-25 pubmed publisher
    ..2 and 14.6, respectively, higher than that of ARB (4.6). ..
  2. Filosa R, Peduto A, Schaible A, Krauth V, Weinigel C, Barz D, et al. Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes. Eur J Med Chem. 2015;94:132-9 pubmed publisher
    ..Together, our detailed SAR study reveals 22c as highly potent 5-LO-selective lead compound in intact cells that warrants further preclinical evaluation as anti-inflammatory agent. ..
  3. Peduto A, Krauth V, Collarile S, Dehm F, Ambruosi M, Belardo C, et al. Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition. Eur J Med Chem. 2016;108:466-475 pubmed publisher
    ..The reported in vivo analysis, together with the accessible synthetic procedure, stimulate for the generation of further potent antinflammatory benzoindoles-based agents. ..
  4. Schaible A, Filosa R, Krauth V, Temml V, Pace S, Garscha U, et al. The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo. Biochem Pharmacol. 2016;112:60-71 pubmed publisher
  5. Di Mola A, Gatta E, Petronzi C, Cupello A, de Caprariis P, Robello M, et al. Synthesis and pharmacological evaluation of functionalized isoindolinones on GABA-activated chloride currents in rat cerebellum granule cells in culture. Bioorg Med Chem Lett. 2016;26:5284-5289 pubmed publisher
  6. Zappavigna S, Scuotto M, Cossu A, Ingrosso D, De Rosa M, Schiraldi C, et al. The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells. J Exp Clin Cancer Res. 2016;35:167 pubmed
    ..RF-Id induced a caspase-dependent apoptosis in GBM cells by inhibiting IAP family proteins and NFκB pathway and represents a promising lead compound for designing a new class of anti-cancer drugs with multiple targets. ..
  7. Peduto A, Scuotto M, Krauth V, Roviezzo F, Rossi A, Temml V, et al. Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase. Eur J Med Chem. 2017;127:715-726 pubmed publisher
    ..Together, we elucidated the optimal alkyl chain pattern of quinones and corresponding hydroquinones and reveal a series of highly potent 5-LO inhibitors with effectiveness in vivo that might be useful as anti-inflammatory drugs. ..
  8. Scuotto M, Abdelnabi R, Collarile S, Schiraldi C, Delang L, Massa A, et al. Discovery of novel multi-target indole-based derivatives as potent and selective inhibitors of chikungunya virus replication. Bioorg Med Chem. 2017;25:327-337 pubmed publisher
    ..The reported computational insights, together with the accessible synthetic procedure, pave the road towards the design of novel synthetic derivatives with enhanced anti-viral activities. ..
  9. D Agostino A, Stellavato A, Corsuto L, Diana P, Filosa R, La Gatta A, et al. Is molecular size a discriminating factor in hyaluronan interaction with human cells?. Carbohydr Polym. 2017;157:21-30 pubmed publisher
    ..Finally our outcomes showed that the lower the fragment size the higher the concern for inflammatory cytokines up-regulation; repair process impairment was highlighted only for 6kDa chains. ..