K Esposito

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. ncbi request reprint Addition of neutral protamine lispro insulin or insulin glargine to oral type 2 diabetes regimens for patients with suboptimal glycemic control: a randomized trial
    Katherine Esposito
    Second University of Naples and Azienda Sanitaria Locale Napoli 5, Naples, Italy
    Ann Intern Med 149:531-9. 2008
  2. ncbi request reprint The effects of a Mediterranean diet on the need for diabetes drugs and remission of newly diagnosed type 2 diabetes: follow-up of a randomized trial
    Katherine Esposito
    Diabetes Unit, University Hospital at the Second University of Naples, Naples, Italy
    Diabetes Care 37:1824-30. 2014
  3. pmc Long-term effect of mediterranean-style diet and calorie restriction on biomarkers of longevity and oxidative stress in overweight men
    Katherine Esposito
    Chair and Division of Metabolic Diseases, Second University of Naples, Piazza L Miraglia, 80138 Napoli, Italy
    Cardiol Res Pract 2011:293916. 2011
  4. pmc Cardiovascular guidelines: separate career may help attenuate controversy
    Katherine Esposito
    Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
    Cardiovasc Diabetol 13:66. 2014
  5. ncbi request reprint Baseline glycemic parameters predict the hemoglobin A1c response to DPP-4 inhibitors : meta-regression analysis of 78 randomized controlled trials with 20,053 patients
    Katherine Esposito
    Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Naples, Italy
    Endocrine 46:43-51. 2014
  6. doi request reprint Metabolic syndrome and endometrial cancer: a meta-analysis
    Katherine Esposito
    Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Piazza L Miraglia 2, 80138, Naples, Italy
    Endocrine 45:28-36. 2014
  7. ncbi request reprint Colorectal cancer association with metabolic syndrome and its components: a systematic review with meta-analysis
    Katherine Esposito
    Department of Cardio Thoracic and Respiratory Sciences, Second University of Naples, Naples, Italy
    Endocrine 44:634-47. 2013
  8. ncbi request reprint Should we abandon statins in the prevention of bone fractures?
    Katherine Esposito
    Department of Cardio Thoracic and Respiratory Sciences, Second University of Naples, Endocrine and Diabetes Unit, Piazza L Miraglia 2, 80138, Naples, Italy
    Endocrine 44:326-33. 2013
  9. doi request reprint Mediterranean diet and metabolic syndrome: an updated systematic review
    Katherine Esposito
    Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Piazza L Miraglia, 80138, Naples, Italy
    Rev Endocr Metab Disord 14:255-63. 2013
  10. doi request reprint Fracture risk and bone mineral density in metabolic syndrome: a meta-analysis
    Katherine Esposito
    Department of Cardio Thoracic and Respiratory Sciences, Second University of Naples, Piazza Luigi Miraglia 2, 80138 Naples, Italy
    J Clin Endocrinol Metab 98:3306-14. 2013

Collaborators

Detail Information

Publications124 found, 100 shown here

  1. ncbi request reprint Addition of neutral protamine lispro insulin or insulin glargine to oral type 2 diabetes regimens for patients with suboptimal glycemic control: a randomized trial
    Katherine Esposito
    Second University of Naples and Azienda Sanitaria Locale Napoli 5, Naples, Italy
    Ann Intern Med 149:531-9. 2008
    ..Neutral protamine lispro (NPL) insulin has demonstrated better glycemic control and similar incidence of hypoglycemic events than that of neutral protamine Hagedorn insulin...
  2. ncbi request reprint The effects of a Mediterranean diet on the need for diabetes drugs and remission of newly diagnosed type 2 diabetes: follow-up of a randomized trial
    Katherine Esposito
    Diabetes Unit, University Hospital at the Second University of Naples, Naples, Italy
    Diabetes Care 37:1824-30. 2014
    ..To assess the long-term effects of dietary interventions on glycemic control, need for diabetes medications, and remission of type 2 diabetes...
  3. pmc Long-term effect of mediterranean-style diet and calorie restriction on biomarkers of longevity and oxidative stress in overweight men
    Katherine Esposito
    Chair and Division of Metabolic Diseases, Second University of Naples, Piazza L Miraglia, 80138 Napoli, Italy
    Cardiol Res Pract 2011:293916. 2011
    ....
  4. pmc Cardiovascular guidelines: separate career may help attenuate controversy
    Katherine Esposito
    Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
    Cardiovasc Diabetol 13:66. 2014
    ....
  5. ncbi request reprint Baseline glycemic parameters predict the hemoglobin A1c response to DPP-4 inhibitors : meta-regression analysis of 78 randomized controlled trials with 20,053 patients
    Katherine Esposito
    Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Naples, Italy
    Endocrine 46:43-51. 2014
    ..The HbA1c response to DPP-4 inhibitors can be modulated mainly by baseline HbA1c and fasting glucose levels: a greater absolute reduction of baseline HbA1c is seen in patients with higher baseline HbA1c and lower fasting glucose level...
  6. doi request reprint Metabolic syndrome and endometrial cancer: a meta-analysis
    Katherine Esposito
    Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Piazza L Miraglia 2, 80138, Naples, Italy
    Endocrine 45:28-36. 2014
    ..Metabolic syndrome is associated with an increased risk of endometrial cancer; among the components of the syndrome, obesity/high waist is that more strongly associated with endometrial cancer...
  7. ncbi request reprint Colorectal cancer association with metabolic syndrome and its components: a systematic review with meta-analysis
    Katherine Esposito
    Department of Cardio Thoracic and Respiratory Sciences, Second University of Naples, Naples, Italy
    Endocrine 44:634-47. 2013
    ..Metabolic syndrome is associated with an increased risk of colorectal cancer incidence and mortality in both sexes. The risk conveyed by the full syndrome is not superior to the sum of its parts...
  8. ncbi request reprint Should we abandon statins in the prevention of bone fractures?
    Katherine Esposito
    Department of Cardio Thoracic and Respiratory Sciences, Second University of Naples, Endocrine and Diabetes Unit, Piazza L Miraglia 2, 80138, Naples, Italy
    Endocrine 44:326-33. 2013
    ..At the moment, the evidence for a role of statins in prevention of osteoporosis is insufficient to recommend starting statin therapy with the aim to prevent osteoporosis...
  9. doi request reprint Mediterranean diet and metabolic syndrome: an updated systematic review
    Katherine Esposito
    Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Piazza L Miraglia, 80138, Naples, Italy
    Rev Endocr Metab Disord 14:255-63. 2013
    ..Considering the magnitude of metabolic syndrome, efforts should be made to encourage adoption of this pattern in Mediterranean countries and similar dietary pattern in countries where metabolic syndrome is prevalent. ..
  10. doi request reprint Fracture risk and bone mineral density in metabolic syndrome: a meta-analysis
    Katherine Esposito
    Department of Cardio Thoracic and Respiratory Sciences, Second University of Naples, Piazza Luigi Miraglia 2, 80138 Naples, Italy
    J Clin Endocrinol Metab 98:3306-14. 2013
    ..The risk of bone fractures in subjects with the metabolic syndrome is unknown. We did a meta-analysis to assess the association between metabolic syndrome, risk of fractures, and bone mineral density (BMD)...
  11. pmc Management of hyperglycemia in type 2 diabetes: evidence and uncertainty
    Katherine Esposito
    Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
    Cardiovasc Diabetol 12:81. 2013
    ..Whether personalized diabetology will improve the quality healthcare practice of diabetes management is unknown, but specific research has been launched...
  12. ncbi request reprint Effect of metabolic syndrome and its components on prostate cancer risk: meta-analysis
    K Esposito
    Department of Cardio Thoracic and Respiratory Sciences, Second University of Naples, Naples, Italy
    J Endocrinol Invest 36:132-9. 2013
    ..Literature data examining the role of metabolic syndrome and its components in prostate cancer risk are limited and contradictory...
  13. ncbi request reprint Humalog (lispro) for type 2 diabetes
    Katherine Esposito
    Second University of Naples, Department of Cardio Thoracic and Respiratory Sciences, Piazza L Miraglia 2, 80138 Naples, Italy
    Expert Opin Biol Ther 12:1541-50. 2012
    ..Type 2 diabetes is a chronic and progressive disease, and ultimately, most patients will require insulin therapy for the optimization of their glycemic control...
  14. pmc Basal supplementation of insulin lispro protamine suspension versus insulin glargine and detemir for type 2 diabetes: meta-analysis of randomized controlled trials
    Katherine Esposito
    Department of Cardio Thoracic and Respiratory Sciences, Second University of Naples, Naples, Italy
    Diabetes Care 35:2698-705. 2012
    ..We compared the effect of insulin lispro protamine suspension (ILPS) with that of insulin glargine and insulin detemir, all given as basal supplementation, in the treatment of patients with type 2 diabetes...
  15. ncbi request reprint Proportion of patients at HbA1c target <7% with eight classes of antidiabetic drugs in type 2 diabetes: systematic review of 218 randomized controlled trials with 78 945 patients
    K Esposito
    Department of Cardio Thoracic and Respiratory Sciences, Second University of Naples, Piazza L Miraglia 2, Naples, Italy
    Diabetes Obes Metab 14:228-33. 2012
    ....
  16. ncbi request reprint The metabolic syndrome: a cause of sexual dysfunction in women
    K Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Int J Impot Res 17:224-6. 2005
    ..8 (0.2/2.9) mg/l, median (interquartile range), P = 0.01). There was an inverse relation between CRP levels and FSFI score (r = -0.32, P=0.02). Investigation of female sexuality is suggested for patients with the metabolic syndrome...
  17. ncbi request reprint Mediterranean diet, endothelial function and vascular inflammatory markers
    Katherine Esposito
    Division of Metabolic Diseases, University of Naples SUN, Naples, Italy
    Public Health Nutr 9:1073-6. 2006
    ..To discuss present knowledge about the relation between adipose tissue, inflammation and the Mediterranean-style diet...
  18. ncbi request reprint Dietary glycemic index and glycemic load are associated with metabolic control in type 2 diabetes: The CAPRI experience
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Metab Syndr Relat Disord 8:255-61. 2010
    ..The aim of the present study was to evaluate the association between the dietary glycemic index (GI) and glycemic load (GL) with metabolic control in type 2 diabetic patients...
  19. ncbi request reprint Mediterranean diet and the metabolic syndrome: the end of the beginning
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Metab Syndr Relat Disord 8:197-200. 2010
    ....
  20. doi request reprint Mediterranean diet and weight loss: meta-analysis of randomized controlled trials
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Metab Syndr Relat Disord 9:1-12. 2011
    ..The epidemiological evidence supporting a causal link between Mediterranean diets and body weight is contrasting. We evaluated the effect of Mediterranean diets on body weight in randomized controlled trials (RCTs) using a meta-analysis...
  21. ncbi request reprint High proportions of erectile dysfunction in men with the metabolic syndrome
    Katherine Esposito
    Division of Metabolic Diseases, Second University of Naples, Piazza L Miraglia, 80138 Naples, Italy
    Diabetes Care 28:1201-3. 2005
  22. ncbi request reprint Association of body weight with sexual function in women
    K Esposito
    Department of Geriatrics and Metabolic Diseases, University of Naples SUN, Naples, Italy
    Int J Impot Res 19:353-7. 2007
    ..On multivariate analysis, both age and BMI explained about 68% of FSFI variance, with a primacy of BMI over age (ratio 4:1). In conclusion, obesity affects several aspects of sexuality in otherwise healthy women with sexual dysfunction...
  23. ncbi request reprint Lifestyle approach for type 2 diabetes and metabolic syndrome
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Division of Metabolic Diseases, Piazza L Miraglia 2, 80138 Napoli, Italy
    Curr Atheroscler Rep 10:523-8. 2008
    ..Reduction of body weight, improvement of the quality of diet, and promotion of physical activity are the main approaches to prevent and treat patients with type 2 diabetes or metabolic syndrome...
  24. ncbi request reprint Obesity, the metabolic syndrome, and sexual dysfunction
    K Esposito
    Department of Geriatrics and Metabolic Diseases, University of Naples SUN, Naples, Italy
    Int J Impot Res 17:391-8. 2005
    ..The adoption of healthy lifestyles can reduce the prevalence of obesity and the metabolic syndrome, and hopefully the burden of sexual dysfunction...
  25. doi request reprint Circulating CD34+ KDR+ endothelial progenitor cells correlate with erectile function and endothelial function in overweight men
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Division of Metabolic Diseases, Second University of Naples, Naples, Italy
    J Sex Med 6:107-14. 2009
    ..Bone marrow-derived endothelial progenitor cells (EPCs) circulate in the peripheral blood and are involved in endothelial homeostasis and repair...
  26. doi request reprint Effects of intensive lifestyle changes on erectile dysfunction in men
    Katherine Esposito
    Division of Metabolic Diseases, Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    J Sex Med 6:243-50. 2009
    ..Limited data are available supporting the notion that treatment of lifestyle risk factors may improve erectile dysfunction (ED)...
  27. ncbi request reprint Endothelial microparticles correlate with erectile dysfunction in diabetic men
    K Esposito
    Division of Metabolic Diseases, University of Naples SUN, Naples, Italy
    Int J Impot Res 19:161-6. 2007
    ..03). EMP are elevated in impotent diabetic subjects and independently involved in the pathogenesis of ED...
  28. ncbi request reprint Dietary factors in erectile dysfunction
    K Esposito
    Division of Metabolic Diseases, University of Naples SUN, Piazza Miraglia, Naples, Italy
    Int J Impot Res 18:370-4. 2006
    ..In conclusion, the results of the present study show that dietary factors may be important in the development of ED: adoption of healthy diets would hopefully help preventing ED...
  29. ncbi request reprint Quantitative sensory and autonomic testing in nondiabetic women with sexual dysfunction
    Katherine Esposito
    Division of Metabolic Diseases, Department of Geriatrics and Metabolic Diseases, University of Naples SUN, Naples, Italy
    J Sex Med 4:1367-72. 2007
    ..Female sexual dysfunction (FSD) is a significant public health problem. There are no reported studies assessing the relation between sexual function and neuropathy in women, except for diabetes mellitus...
  30. ncbi request reprint Mediterranean diet improves sexual function in women with the metabolic syndrome
    K Esposito
    Division of Metabolic Diseases, Department of Geriatrics and Metabolic Diseases, University of Naples SUN, Naples, Italy
    Int J Impot Res 19:486-91. 2007
    ..A Mediterranean-style diet might be effective in ameliorating sexual function in women with metabolic syndrome...
  31. ncbi request reprint Mediterranean diet improves erectile function in subjects with the metabolic syndrome
    K Esposito
    Division of Metabolic Diseases, University of Naples SUN, Piazza Miraglia, Naples, Italy
    Int J Impot Res 18:405-10. 2006
    ..Mediterranean-style diet rich in whole grain, fruits, vegetables, legumes, walnut, and olive oil might be effective per se in reducing the prevalence of ED in men with the metabolic syndrome...
  32. doi request reprint Obesity and sexual dysfunction, male and female
    K Esposito
    Division of Metabolic Diseases, Department of Geriatrics and Metabolic Diseases, University of Naples SUN, Naples, Italy
    Int J Impot Res 20:358-65. 2008
    ....
  33. doi request reprint Effects of pioglitazone versus metformin on circulating endothelial microparticles and progenitor cells in patients with newly diagnosed type 2 diabetes--a randomized controlled trial
    K Esposito
    Department of Geriatrics and Metabolic Diseases, Azienda Universitaria Policlinico, Second University of Naples, Italy
    Diabetes Obes Metab 13:439-45. 2011
    ..We compared the effects of pioglitazone versus metformin on the circulating numbers of EMPs and EPCs in patients with newly diagnosed type 2 diabetes...
  34. ncbi request reprint Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial
    Katherine Esposito
    Center for Obesity Management, Second University of Naples, Naples, Italy
    JAMA 291:2978-84. 2004
    ..Healthy lifestyle factors are associated with maintenance of erectile function in men...
  35. ncbi request reprint Meal modulation of circulating interleukin 18 and adiponectin concentrations in healthy subjects and in patients with type 2 diabetes mellitus
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Piazza L Miraglia, 80138 Naples, Italy
    Am J Clin Nutr 78:1135-40. 2003
    ..A single high-fat meal induces endothelial activation, which is associated with increased serum concentrations of inflammatory cytokines...
  36. doi request reprint Current insulin analogues in the treatment of diabetes: emphasis on type 2 diabetes
    Katherine Esposito
    Second University of Naples, Department of Cardio Thoracic and Respiratory Sciences, Piazza Miraglia 2, 80138, Naples, Italy
    Expert Opin Biol Ther 12:209-21. 2012
    ..These limitations have fuelled the development of insulin analogues, which mainly fall into two different categories: short-acting and long-acting analogues...
  37. ncbi request reprint Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial
    Katherine Esposito
    Center for Obesity Management, Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    JAMA 289:1799-804. 2003
    ..Obesity is an independent risk factor for cardiovascular disease, which may be mediated by increased secretion of proinflammatory cytokines by adipose tissue...
  38. ncbi request reprint Obesity, cytokines and endothelial dysfunction: a link for the raised cardiovascular risk associated with visceral obesity
    K Esposito
    Center for Obesity Management, Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    J Endocrinol Invest 25:646-9. 2002
  39. doi request reprint Lifestyle/dietary recommendations for erectile dysfunction and female sexual dysfunction
    Katherine Esposito
    Department of Cardio Thoracic and Respiratory Sciences, Second University of Naples, Piazza L Miraglia 2, 80138 Naples, Italy
    Urol Clin North Am 38:293-301. 2011
    ..Beyond the specific effects on sexual dysfunctions in men and women, adoption of these measures promotes a healthier life and increased well-being, which may help reduce the burden of sexual dysfunction...
  40. ncbi request reprint Autonomic dysfunction associates with prolongation of QT intervals and blunted night BP in obese women with visceral obesity
    K Esposito
    Department of Geriatrics and Metabolic Disease, Second University of Naples, Naples, Italy
    J Endocrinol Invest 25:RC32-5. 2002
    ..Autonomic dysfunction may be the common mechanism for this association...
  41. doi request reprint GLP-1 receptor agonists and HBA1c target of <7% in type 2 diabetes: meta-analysis of randomized controlled trials
    K Esposito
    Department of Cario Thoracic and Respiratory Sciences, Second University of Naples, Naples, Italy
    Curr Med Res Opin 27:1519-28. 2011
    ..Glucagon-like peptide-1 (GLP-1) receptor agonists are available for the treatment of type 2 diabetes. We assessed the efficacy of exenatide and liraglutide to reach the HbA(1c) target of <7% in people with type 2 diabetes...
  42. ncbi request reprint Mediterranean diet and prevention of coronary heart disease
    K Esposito
    Department of Geriatrics and Metabolic Diseases, Cardiovascular Research Center, Second University of Naples, Italy
    J Endocrinol Invest 25:296-9. 2002
  43. ncbi request reprint Determinants of female sexual dysfunction in type 2 diabetes
    K Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Piazza Miraglia, Naples, Italy
    Int J Impot Res 22:179-84. 2010
    ..In the meantime, evaluation of female sexuality should become a routine evaluation in women with type 2 diabetes, such as other diabetic complications...
  44. doi request reprint JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses high fat diet-induced obesity and glucose intolerance in Sprague-Dawley rats
    T Hata
    Japan Tobacco, Central Pharmaceutical Research Institute, Biological Pharmacological Research Laboratories, Osaka
    Diabetes Obes Metab 13:446-54. 2011
    ..We investigated the effects of JTT-130, a novel intestine-specific MTP inhibitor, on high fat diet-induced obesity and glucose intolerance...
  45. ncbi request reprint Sympathovagal balance, nighttime blood pressure, and QT intervals in normotensive obese women
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Cardiovascular Research Center, Second University of Naples, Naples, Italy
    Obes Res 11:653-9. 2003
    ..We describe associations among the heart-rate-corrected QT (QTc) interval, QTc dispersion (QTc-d), circadian BP variation, and autonomic function in obese normotensive women and the effect of sustained weight loss...
  46. doi request reprint Interleukin-20 circulating levels in obese women: effect of weight loss
    M I Maiorino
    Department of Geriatrics and Metabolic Diseases, Division of Metabolic Diseases, Second University of Naples, Piazza L Miraglia, 80138 Naples, Italy
    Nutr Metab Cardiovasc Dis 20:180-5. 2010
    ..The aim of this study was to determine whether circulating levels of IL-20 are elevated in obese women and whether they could be affected by a substantial decrease in body weight...
  47. ncbi request reprint Adherence to a Mediterranean diet and glycaemic control in Type 2 diabetes mellitus
    K Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, 80138 Naples, Italy
    Diabet Med 26:900-7. 2009
    ..Mediterranean-type diets reduce the risk of Type 2 diabetes. Whether a Mediterranean-type diet improves glycaemic control in diabetes remains unknown...
  48. ncbi request reprint Erectile dysfunction associates with endothelial dysfunction and raised proinflammatory cytokine levels in obese men
    F Giugliano
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    J Endocrinol Invest 27:665-9. 2004
    ....
  49. ncbi request reprint Effect of liposuction on insulin resistance and vascular inflammatory markers in obese women
    G Giugliano
    Chair of Plastic and Reconstructive Surgery, Second University of Naples, Naples, Italy
    Br J Plast Surg 57:190-4. 2004
    ..Moreover, it is associated with amelioration of insulin resistance and reduced circulating markers of vascular inflammation which may help obese subjects to reduce their cardiovascular risk...
  50. ncbi request reprint Determinants of erectile dysfunction in type 2 diabetes
    F Giugliano
    Division of Urology, Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Int J Impot Res 22:204-9. 2010
    ..These results encourage the implementation of current medical guidelines that place intensive lifestyle changes as the first step of the management of type 2 diabetes...
  51. ncbi request reprint Blood pressure and cardiac autonomic nervous system in obese type 2 diabetic patients: effect of metformin administration
    Daniela Manzella
    Department of Geriatric Medicine and Metabolic Diseases, Internal Medicine IV, Second University of Naples, Piazza Miraglia 2, I 10838 Naples, Italy
    Am J Hypertens 17:223-7. 2004
    ..Metformin improves insulin action and lower plasma FFA concentrations. We investigate the possible effect of metformin on arterial blood pressure (BP) and cardiac sympathetic nervous system...
  52. ncbi request reprint Oxidative stress in the metabolic syndrome
    K Esposito
    Division of Metabolic Diseases, Department of Geriatrics and Metabolic Diseases, University of Naples SUN, Naples, Italy
    J Endocrinol Invest 29:791-5. 2006
    ..24, p<0.05). The oxidative stress that accompanies the metabolic syndrome is associated with both insulin resistance and endothelial dysfunction, providing a connection which is highly deleterious for vascular functions...
  53. ncbi request reprint Effect of a multidisciplinary program of weight reduction on endothelial functions in obese women
    G Nicoletti
    Chair of Plastic and Reconstructive Surgery, Second University of Naples, Naples, Italy
    J Endocrinol Invest 26:RC5-8. 2003
    ....
  54. ncbi request reprint Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial
    Katherine Esposito
    Chair and Division of Metabolic Diseases, Second University of Naples, Naples, Italy
    JAMA 292:1440-6. 2004
    ..The metabolic syndrome has been identified as a target for dietary therapies to reduce risk of cardiovascular disease; however, the role of diet in the etiology of the metabolic syndrome is poorly understood...
  55. ncbi request reprint Elevated plasma free fatty acid concentrations do not modify cardiac repolarization in patients treated by electrolyte-glucose-insulin infusion
    F Nappo
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    J Endocrinol Invest 25:RC19-22. 2002
    ..In the setting of a balanced parenteral nutrition, acute elevation of plasma free fatty acid concentrations in critically ill patients do not modify ventricular repolarization...
  56. ncbi request reprint Defining the role of insulin lispro in the management of postprandial hyperglycaemia in patients with type 2 diabetes mellitus
    D Giugliano
    Department of Geriatrics and Metabolic Diseases, Metabolic Diseases Division, University of Naples SUN, Naples, Italy
    Clin Drug Investig 28:199-210. 2008
    ....
  57. ncbi request reprint Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals
    Francesco Nappo
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    J Am Coll Cardiol 39:1145-50. 2002
    ..To compare the effect of a high-fat meal and a high-carbohydrate meal (pizza), with and without antioxidant vitamins, on endothelial activation in healthy subjects and in patients with type 2 diabetes mellitus...
  58. ncbi request reprint Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year
    Patrizia Ziccardi
    Department of Geriatrics and Metabolic Diseases, Chair of Metabolic Diseases, Second University of Naples, Italy
    Circulation 105:804-9. 2002
    ..Visceral fat is a key regulator site for the process of inflammation, and atherosclerotic lesions are essentially an inflammatory response...
  59. ncbi request reprint Effect of rosiglitazone on endothelial function and inflammatory markers in patients with the metabolic syndrome
    Katherine Esposito
    Division of Metabolic Diseases, University of Naples SUN, Naples, Italy
    Diabetes Care 29:1071-6. 2006
    ..The aim of this study was to assess the effect of rosiglitazone on endothelial function and inflammatory markers in patients with the metabolic syndrome...
  60. doi request reprint Lifestyle and metabolic approaches to maximizing erectile and vascular health
    D R Meldrum
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Naples SUN, Naples, Italy
    Int J Impot Res 24:61-8. 2012
    ....
  61. ncbi request reprint Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress
    Katherine Esposito
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Italy
    Circulation 106:2067-72. 2002
    ..We assessed the role of glucose in the regulation of circulating levels of IL-6, TNF-alpha, and interleukin-18 (IL-18) in subjects with normal or impaired glucose tolerance (IGT), as well as the effect of the antioxidant glutathione...
  62. ncbi request reprint Adherence to Mediterranean diet and erectile dysfunction in men with type 2 diabetes
    Francesco Giugliano
    Division of Urology, Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    J Sex Med 7:1911-7. 2010
    ..There are no reported studies assessing the relation between diet and erectile dysfunction (ED) in men with diabetes...
  63. ncbi request reprint Effects of a Mediterranean-style diet on the need for antihyperglycemic drug therapy in patients with newly diagnosed type 2 diabetes: a randomized trial
    Katherine Esposito
    Second University of Naples and ASLNA5, Vico Equense Sorrento, Naples, Italy
    Ann Intern Med 151:306-14. 2009
    ..Low-carbohydrate and low-fat calorie-restricted diets are recommended for weight loss in overweight and obese people with type 2 diabetes...
  64. ncbi request reprint Oral amino acid administration decreases oxidative stress and improves brachial reactivity in elderly individuals
    Daniela Manzella
    Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Naples, Italy
    Am J Hypertens 18:858-63. 2005
    ..Endothelial dysfunction is recognized as a key early event in atherogenesis. In the present study, we evaluated the possible beneficial effect of amino acid administration on endothelial regulation in elderly subjects...
  65. ncbi request reprint Role of adipokines in the obesity-inflammation relationship: the effect of fat removal
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Cardiovascular Research Center, University of Naples SUN, Italy
    Plast Reconstr Surg 118:1048-57; discussion 1058-9. 2006
    ....
  66. ncbi request reprint Female sexual dysfunction in women with thyroid disorders
    D Pasquali
    Department of Cardio Thoracic and Respiratory Sciences, Unit of Endocrinology and Diabetes Clinic, Second University of Naples, Via Pansini 5, 80131 Naples, Italy
    J Endocrinol Invest 36:729-33. 2013
    ..Few data exist on the prevalence of female sexual dysfunction (FSD) in thyroid disorders...
  67. doi request reprint Dipeptidyl peptidase-4 inhibitors and HbA1c target of <7% in type 2 diabetes: meta-analysis of randomized controlled trials
    K Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Obes Metab 13:594-603. 2011
    ..We assessed the efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors vildagliptin, sitagliptin, saxagliptin and alogliptin to reach the haemoglobin HbA1c target of <7% in people with type 2 diabetes...
  68. ncbi request reprint Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1
    R Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Diabetologia 45:1172-81. 2002
    ..This study aimed to evaluate the effects of hyperglycaemia on the evolution of myocardial infarction and the expression of the transcriptional factor for angiogenesis hypoxia-inducible factor 1alpha (HIF-1alpha) in the rat...
  69. ncbi request reprint Simvastatin normalizes qtc dispersion and reduces ventricular electrical instability in isolated hypercholesterolemia
    P Gualdiero
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    J Endocrinol Invest 25:RC16-8. 2002
    ..37, p<0.01) and QTc dispersion (r=0.49, p<0.01). In subjects with isolated hypercholesterolemia simvastatin may reduce the cardiovascular risk associated with ventricular electrical instability...
  70. doi request reprint Relationship of baseline HbA1c, HbA1c change and HbA1c target of < 7% with insulin analogues in type 2 diabetes: a meta-analysis of randomised controlled trials
    D Giugliano
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Int J Clin Pract 65:602-12. 2011
    ....
  71. ncbi request reprint Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Am J Clin Nutr 77:139-43. 2003
    ..Persons following current dietary guidelines have a lower risk of mortality from coronary heart disease...
  72. ncbi request reprint Impairment of coronary circulation by acute hyperhomocysteinaemia and reversal by antioxidant vitamins
    A Coppola
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    J Intern Med 256:398-405. 2004
    ..To evaluate the effect of acute hyperhomocysteinaemia with and without antioxidant vitamins pretreatment on coronary circulation and circulating chemokine levels...
  73. doi request reprint Post-meal glucose peaks at home associate with carotid intima-media thickness in type 2 diabetes
    Katherine Esposito
    Chair and Division of Metabolic Diseases, Second University of Naples, Piazza L Miraglia, 80138 Napoli, Italy
    J Clin Endocrinol Metab 93:1345-50. 2008
    ..Two-hour postprandial hyperglycemia is related to chronic complications of diabetes and is currently used in the international guidelines to drive the therapy...
  74. ncbi request reprint Effects of stress hyperglycemia on acute myocardial infarction: role of inflammatory immune process in functional cardiac outcome
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Care 26:3129-35. 2003
    ..We examined the association between plasma glucose levels, circulating inflammatory markers, T-cell activation, and functional cardiac outcome in patients with first MI...
  75. pmc Characterization of a novel polymorphism in PPARG regulatory region associated with type 2 diabetes and diabetic retinopathy in Italy
    Valerio Costa
    Institute of Genetics and Biophysics A Buzzati Traverso IGB, National Research Council CNR, Naples, Italy
    J Biomed Biotechnol 2009:126917. 2009
    ..In the analyzed population, this variant represents a genetic risk factor for developing the diabetic retinopathy, whereas Pro12Ala and C1431T do not...
  76. ncbi request reprint Hyperglycemia and heart dysfunction: an oxidant mechanism contributing to heart failure in diabetes
    K Esposito
    Department of Geriatrics and Metabolic Diseases, Cardiovascular Research Centre, Second University of Naples, Italy
    J Endocrinol Invest 25:485-8. 2002
  77. ncbi request reprint Effects of insulin on left ventricular function during dynamic exercise in overweight and obese subjects
    Ferdinando C Sasso
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Eur Heart J 26:1205-12. 2005
    ..We designed this study in order to determine the effect of insulin on cardiac function in overweight and obese subjects during exercise...
  78. ncbi request reprint Weight loss reduces interleukin-18 levels in obese women
    Katherine Esposito
    Center for Obesity Management, Department of Geriatrics and Metabolic Diseases, Chair of Plastic and Reconstructive Surgery, Second University of Naples, 80138 Naples, Italy
    J Clin Endocrinol Metab 87:3864-6. 2002
    ..In obese women, IL-18 levels are associated with body weight and abdominal fat deposition; weight loss is an important intervention to reduce IL-18 levels. IL-18 may be a novel cytokine operating in human obesity...
  79. ncbi request reprint Expression of angiogenic factors during acute coronary syndromes in human type 2 diabetes
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Section of Pathology, Second University of Naples, Naples, Italy
    Diabetes 53:2383-91. 2004
    ..001). Diabetes is associated with increased myocardial tissue levels of iNOS, O(2)(-), and nitrotyrosine and reduced expression of myocardial angiogenesis factors during ischemia...
  80. ncbi request reprint Regression of carotid atherosclerosis by control of morning blood pressure peak in newly diagnosed hypertensive patients
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples, Italy
    Am J Hypertens 18:308-18. 2005
    ....
  81. pmc Efficacy of insulin analogs in achieving the hemoglobin A1c target of <7% in type 2 diabetes: meta-analysis of randomized controlled trials
    Dario Giugliano
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy
    Diabetes Care 34:510-7. 2011
    ..We compared the effect of basal, biphasic, prandial, and basal-bolus insulin regimens with insulin analogs to reach the hemoglobin A(1c) (HbA(1c)) target of <7% in people with type 2 diabetes...
  82. ncbi request reprint Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Policlinico Universitario, Piazza L Miraglia, 80138 Naples, Italy
    Circulation 110:214-9. 2004
    ....
  83. ncbi request reprint Absence of inducible nitric oxide synthase reduces myocardial damage during ischemia reperfusion in streptozotocin-induced hyperglycemic mice
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes 53:454-62. 2004
    ..The beneficial role of iNOS in modulating defensive responses against ischemia/reperfusion injury seems to be abolished in diabetic mice...
  84. ncbi request reprint Effect of weight loss on cardiac synchronization and proinflammatory cytokines in premenopausal obese women
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Care 27:47-52. 2004
    ..We examined the relationship of ventricular synchronization abnormalities with the concentration of proinflammatory cytokines in obese women at baseline and after sustained weight loss...
  85. ncbi request reprint Association of low interleukin-10 levels with the metabolic syndrome in obese women
    Katherine Esposito
    Center for Obesity Management, Department of Geriatrics and Metabolic Diseases, Second University of Naples, 80138 Naples, Italy
    J Clin Endocrinol Metab 88:1055-8. 2003
    ..These results show that circulating levels of the anti-inflammatory cytokine IL-10 are elevated in obese women and that low IL-10 levels are associated with the metabolic syndrome...
  86. ncbi request reprint Morning blood pressure peak, QT intervals, and sympathetic activity in hypertensive patients
    Raffaele Marfella
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Naples Italy
    Hypertension 41:237-43. 2003
    ..The prolongation of cardiac repolarization times and morning sympathetic overactivity coexist in hypertensive patients with morning BP peaks, and they might contribute to raised cardiovascular risk in these patients...
  87. ncbi request reprint Cytokine pattern in postmenopause
    Michele Cioffi
    Patologia Clinica, Dipartimento di Patologia Generale, Facolta di Medicina e Chirurgia, Seconda Universita degli Studi di Napoli, Via S Andrea delle Dame, 2 80138, Naples, Italy
    Maturitas 41:187-92. 2002
    ..The present study was undertaken to evaluate the pattern of serum cytokine production in postmenopausal women and the relationship with the hormonal status. A group of fertile women served as controls...
  88. ncbi request reprint Effect of a single high-fat meal on endothelial function in patients with the metabolic syndrome: role of tumor necrosis factor-alpha
    Katherine Esposito
    Chair and Division of Metabolic Diseases, University of Naples SUN, Piazza L Miraglia, 80138 Naples, Italy
    Nutr Metab Cardiovasc Dis 17:274-9. 2007
    ..The aim of this study was to assess the effect of a high-fat meal on endothelial function in patients with the metabolic syndrome...
  89. ncbi request reprint Sexual dysfunction and the Mediterranean diet
    Dario Giugliano
    Division of Metabolic Diseases, University of Naples SUN, Naples, Italy
    Public Health Nutr 9:1118-20. 2006
    ..To discuss present knowledge about the relation between sexual dysfunction, metabolic factors and the Mediterranean-style diet...
  90. ncbi request reprint The ubiquitin-proteasome system and inflammatory activity in diabetic atherosclerotic plaques: effects of rosiglitazone treatment
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University Naples, Italy
    Diabetes 55:622-32. 2006
    ....
  91. ncbi request reprint Are there specific treatments for the metabolic syndrome?
    Dario Giugliano
    Department of Geriatrics and Metabolic Diseases, Division of Metabolic Diseases, University of Naples SUN, Naples, Italy
    Am J Clin Nutr 87:8-11. 2008
    ....
  92. ncbi request reprint Glucose metabolism and hyperglycemia
    Dario Giugliano
    Department of Geriatrics and Metabolic Diseases, University of Naples SUN, Italy
    Am J Clin Nutr 87:217S-222S. 2008
    ..The goal of therapy should be to achieve glycemic status as near to normal as safely possible in all 3 components of glycemic control: HbA1c, fasting glucose, and postmeal glucose peak...
  93. doi request reprint Mediterranean diet and metabolic diseases
    Dario Giugliano
    Department of Geriatrics and Metabolic Diseases, Division of Metabolic Diseases, University of Naples SUN, Naples, Italy
    Curr Opin Lipidol 19:63-8. 2008
    ....
  94. ncbi request reprint Mediterranean diet and cardiovascular health
    Dario Giugliano
    Division of Metabolic Diseases, Department of Geriatrics and Metabolic Diseases, Cardiovascular Research Centre, Second University of Naples, Naples, Italy
    Ann N Y Acad Sci 1056:253-60. 2005
    ....
  95. ncbi request reprint Phenotypic assessment of endothelial microparticles in diabetic and nondiabetic men with erectile dysfunction
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Division of Metabolic Diseases, Second University of Naples, Naples, Italy
    J Sex Med 5:1436-42. 2008
    ..Endothelial microparticles (EMPs) may play a role as biomarkers of vascular injury. EMPs are higher in men with diabetes diabetic men with erectile dysfunction (ED) than in nondiabetic potent men...
  96. ncbi request reprint The effects of diet on inflammation: emphasis on the metabolic syndrome
    Dario Giugliano
    Division of Metabolic Diseases, Center of Excellence for Cardiovascular Diseases, University of Naples SUN, Italy
    J Am Coll Cardiol 48:677-85. 2006
    ..Western dietary patterns warm up inflammation, while prudent dietary patterns cool it down...
  97. doi request reprint Prevention of type 2 diabetes by dietary patterns: a systematic review of prospective studies and meta-analysis
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Metab Syndr Relat Disord 8:471-6. 2010
    ..Healthy diets can help people to live more years without type 2 diabetes...
  98. ncbi request reprint Circulating endothelial progenitor cells in acromegaly
    G Bellastella
    Unit of Metabolic Diseases, Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    J Endocrinol Invest 36:825-30. 2013
    ..However, the levels of EPCs and their role in acromegalic patients have never been investigated...
  99. ncbi request reprint Prevention and control of type 2 diabetes by Mediterranean diet: a systematic review
    Katherine Esposito
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes Res Clin Pract 89:97-102. 2010
    ..The evidence so far accumulated suggests that adopting a Mediterranean diet may help prevent type 2 diabetes, and also improve glycaemic control and cardiovascular risk in persons with established diabetes...