Antonio De Luca

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. doi request reprint Helicobacter pylori heat shock protein B (HspB) localizes in vivo in the gastric mucosa and MALT lymphoma
    Antonio De Luca
    Department of Medicine and Public Health, Second University of Naples, Naples, Italy
    J Cell Physiol 216:78-82. 2008
  2. ncbi request reprint Localization and distribution of wolframin in human tissues
    Maria De Falco
    Department of Biological Sciences, Section of Evolutionary and Comparative Biology, University of Naples Federico II, Naples, Italy
    Front Biosci (Elite Ed) 4:1986-98. 2012
  3. ncbi request reprint Coexpression of Helicobacter pylori's proteins CagA and HspB induces cell proliferation in AGS gastric epithelial cells, independently from the bacterial infection
    Antonio De Luca
    Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Via L Armanni 5, 80138 Naples, Italy
    Cancer Res 63:6350-6. 2003
  4. ncbi request reprint Effects of Helicobacter pylori infection on cell cycle progression and the expression of cell cycle regulatory proteins
    Antonio De Luca
    Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Naples, Italy
    J Cell Physiol 200:334-42. 2004
  5. pmc p300/cAMP-response-element-binding-protein ('CREB')-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptor
    Antonio De Luca
    Department of Experimental Medicine and Pathology, IRCCS, Neuromed, Rome, Italy
    Biochem J 369:477-84. 2003
  6. doi request reprint Role of FAP48 in HIV-associated lipodystrophy
    Vincenzo Esposito
    Third Division Cotugno Hospital, Naples, Italy
    J Cell Biochem 113:3446-54. 2012
  7. doi request reprint Amprenavir inhibits the migration in human hepatocarcinoma cell and the growth of xenografts
    Vincenzo Esposito
    Third Division of Infection Diseases, AORN dei Colli, Naples, Italy
    J Cell Physiol 228:640-5. 2013
  8. ncbi request reprint Pkn is a novel partner of cyclin T2a in muscle differentiation
    Giuliano Cottone
    Department for the Development of Therapeutic Programs, Center for Experimental Research, Regina Elena Cancer Institute, Rome, Italy
    J Cell Physiol 207:232-7. 2006
  9. ncbi request reprint Suppression of pre adipocyte differentiation and promotion of adipocyte death by anti-HIV drugs
    Lucrezia Manente
    Department of Medicine and Public Health, Section of Human Anatomy, Second University of Naples, Naples, Italy
    In Vivo 26:287-91. 2012
  10. pmc The pattern of expression of Notch protein members in normal and pathological endometrium
    Luigi Cobellis
    Department of Gynaecology, Obstetric and Reproductive Science, Second University of Studies of Naples, Naples, Italy
    J Anat 213:464-72. 2008

Collaborators

Detail Information

Publications51

  1. doi request reprint Helicobacter pylori heat shock protein B (HspB) localizes in vivo in the gastric mucosa and MALT lymphoma
    Antonio De Luca
    Department of Medicine and Public Health, Second University of Naples, Naples, Italy
    J Cell Physiol 216:78-82. 2008
    ..In conclusion, our observations suggest a possible involvement of HspB in the pathogenesis of H. pylori-related pathologies such as gastritis, ulcer and gastric cancer...
  2. ncbi request reprint Localization and distribution of wolframin in human tissues
    Maria De Falco
    Department of Biological Sciences, Section of Evolutionary and Comparative Biology, University of Naples Federico II, Naples, Italy
    Front Biosci (Elite Ed) 4:1986-98. 2012
    ..The immunopositivity in adult human tissues suggests that it may function maintaining physiological cellular homeostasis...
  3. ncbi request reprint Coexpression of Helicobacter pylori's proteins CagA and HspB induces cell proliferation in AGS gastric epithelial cells, independently from the bacterial infection
    Antonio De Luca
    Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Via L Armanni 5, 80138 Naples, Italy
    Cancer Res 63:6350-6. 2003
    ..All these data suggest that CagA and HspB, independently from the bacterial infection, have a direct effect on the cell growth of the gastric cells acting on the G(1)-S checkpoint of the cell cycle...
  4. ncbi request reprint Effects of Helicobacter pylori infection on cell cycle progression and the expression of cell cycle regulatory proteins
    Antonio De Luca
    Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Naples, Italy
    J Cell Physiol 200:334-42. 2004
    ..The study of mechanisms of interaction between the bacterium and gastric cells will surely help to prevent the increase and diffusion of malignancies all over the world...
  5. pmc p300/cAMP-response-element-binding-protein ('CREB')-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptor
    Antonio De Luca
    Department of Experimental Medicine and Pathology, IRCCS, Neuromed, Rome, Italy
    Biochem J 369:477-84. 2003
    ..In addition, it is speculated that p300 might modulate the activity of the TR-RxR-MEF2A complex by recruiting a hypothetical endogenous inhibitor which may act like adenovirus E1A...
  6. doi request reprint Role of FAP48 in HIV-associated lipodystrophy
    Vincenzo Esposito
    Third Division Cotugno Hospital, Naples, Italy
    J Cell Biochem 113:3446-54. 2012
    ..In conclusion, this molecule could be a potential target for novel therapeutic approaches to the HAART related lipodystrophy in HIV patients...
  7. doi request reprint Amprenavir inhibits the migration in human hepatocarcinoma cell and the growth of xenografts
    Vincenzo Esposito
    Third Division of Infection Diseases, AORN dei Colli, Naples, Italy
    J Cell Physiol 228:640-5. 2013
    ..In summary these findings suggest novel anti-neoplastic action of Amprenavir on liver cancer showing the possibility of novel combination therapies...
  8. ncbi request reprint Pkn is a novel partner of cyclin T2a in muscle differentiation
    Giuliano Cottone
    Department for the Development of Therapeutic Programs, Center for Experimental Research, Regina Elena Cancer Institute, Rome, Italy
    J Cell Physiol 207:232-7. 2006
    ..Taken together, our data strengthen the hypothesis that Cyclin T2a plays a role in muscle differentiation, and propose PKNalpha as a novel partner of Cyclin T2a in this process...
  9. ncbi request reprint Suppression of pre adipocyte differentiation and promotion of adipocyte death by anti-HIV drugs
    Lucrezia Manente
    Department of Medicine and Public Health, Section of Human Anatomy, Second University of Naples, Naples, Italy
    In Vivo 26:287-91. 2012
    ....
  10. pmc The pattern of expression of Notch protein members in normal and pathological endometrium
    Luigi Cobellis
    Department of Gynaecology, Obstetric and Reproductive Science, Second University of Studies of Naples, Naples, Italy
    J Anat 213:464-72. 2008
    ..Deregulation of these functions may induce the onset of several endometrial pathologies from polyps to cancer...
  11. ncbi request reprint Analysis of HtrA1 serine protease expression in human lung cancer
    Vincenzo Esposito
    Third Division, Cotugno Hospital, Naples, Italy
    Anticancer Res 26:3455-9. 2006
    ..Our data suggest that HtrA1 may be involved in lung cancer progression by targeting several molecular pathways...
  12. ncbi request reprint Characterization of tissue specific expression of Notch-1 in human tissues
    Alfonso Baldi
    Department of Biochemistry and Biophysics F Cedrangolo, Section of Pathologic Anatomy, Second University of Naples, Italy
    Biol Cell 96:303-11. 2004
    ....
  13. ncbi request reprint Ferritin contributes to melanoma progression by modulating cell growth and sensitivity to oxidative stress
    Alfonso Baldi
    Laboratory C, Department for the Development of Therapeutic Programs, Center for Experimental Research, Regina Elena Cancer Institute, Rome, Italy
    Clin Cancer Res 11:3175-83. 2005
    ..Here, we attempted to characterize the role of ferritin in the biology of human melanoma and in the progression of this disease...
  14. pmc Evaluation of cyclin D1 expression and its subcellular distribution in mouse tissues
    Maria De Falco
    Department of Evolutive and Comparative Biology, University of Naples Federico II, Naples, Italy
    J Anat 205:405-12. 2004
    ....
  15. ncbi request reprint Distribution of Notch protein members in normal and preeclampsia-complicated placentas
    Luigi Cobellis
    Department of Gynaecology, Obstetric, and Reproductive Science, Second University of Naples, Naples, Italy
    Cell Tissue Res 330:527-34. 2007
    ....
  16. ncbi request reprint Identification of protein-protein interactions of human HtrA1
    Mara Campioni
    Department of Biochemistry, Section of Pathology, Second University of Naples, Naples, Italy
    Front Biosci (Elite Ed) 3:1493-9. 2011
    ....
  17. ncbi request reprint Distribution of the serine protease HtrA1 in normal human tissues
    Antonio De Luca
    Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Naples, Italy
    J Histochem Cytochem 51:1279-84. 2003
    ..This suggests a possible role for HtrA1 in the modulation of tissue activity in this organ. The various expression levels in human tissues indicate several possible roles for HtrA1 in different cell types...
  18. ncbi request reprint Modulation of Bax expression in physiological and pathological human placentas throughout pregnancy
    Luigi Cobellis
    Department of Gynecology, Obstetric and Reproductive Science Section of Clinical Anatomy, Second University of Naples, Italy
    In Vivo 21:777-83. 2007
    ..Our results seem to suggest that deregulation of apoptotic turnover may lead to placental dysfunction and pathologies...
  19. ncbi request reprint Localization and modulation of NEDD8 protein in the human placenta
    Angela Lucariello
    Section of Human Anatomy, Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Via L Armanni 5, 80138 Naples, Italy
    In Vivo 27:501-6. 2013
    ..NEDD8 affects the signaling of various molecules but the major cellular target proteins are cullins. The neddylation process is correlated closely with apoptosis, cell-cycle regulation, embryogenesis and development...
  20. doi request reprint The Helicobacter pylori protein HspB interferes with Nrf2/Keap1 pathway altering the antioxidant response of Ags cells
    Elisabetta Buommino
    Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Second University of Naples, Naples, Italy
    Helicobacter 17:417-25. 2012
    ..Nrf2 signaling is repressed by Keap1 at basal condition and induced by oxidative stress. The aim of our study was to analyze whether the H. pylori proteins interfered in the Nrf2/Keap1 pathway...
  21. ncbi request reprint RACK1 is a functional target of the E1A oncoprotein
    Anna Severino
    Laboratory C, Department for the Development of Therapeutic Programs, Center for Experimental Research, Regina Elena Cancer Institute, Rome, Italy
    J Cell Physiol 199:134-9. 2004
    ..These results suggest that RACK1 signaling pathway may be a functional target of E1A, contributing to E1A oncogenic effect in the host cells...
  22. doi request reprint The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein
    Mara Campioni
    Department of Biochemistry, Section of Pathology, Second University of Naples, Via L Armanni 5, 80138 Naples, Italy
    Mol Cancer Res 8:1248-60. 2010
    ..Considering that HtrA1 levels are significantly increased during embryogenesis, we speculate that one of the targets of HtrA1 activity during fetal development is the TSC2-TSC1 pathway...
  23. ncbi request reprint Pattern of expression of HtrA1 during mouse development
    Antonio De Luca
    Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Naples, Italy
    J Histochem Cytochem 52:1609-17. 2004
    ..An exhaustive knowledge of the different cell- and tissue-specific patterns of expression of HtrA1 in normal mouse embryos is essential for a critical evaluation of the exact role played by this protein during development...
  24. pmc Modulation of wolframin expression in human placenta during pregnancy: comparison among physiological and pathological states
    Angela Lucariello
    Department of Mental and Physical Health and Preventive Medicine, Section of Human Anatomy, Second University of Naples, Largo Madonna delle Grazie, 80138 Naples, Italy
    Biomed Res Int 2014:985478. 2014
    ..The decrease in wolframin expression in diabetic placenta suggests that this protein may participate in maintaining the physiologic glucose homeostasis in this organ...
  25. ncbi request reprint Comparative transcriptional profiling in HIV-infected patients using human stress arrays: clues to metabolic syndrome
    Vincenzo Esposito
    Third Division Cotugno Hospital, Naples, Italy
    In Vivo 26:237-42. 2012
    ....
  26. ncbi request reprint E1A deregulates the centrosome cycle in a Ran GTPase-dependent manner
    Antonio De Luca
    Department for the Development of Therapeutic Programs, Laboratory C, Regina Elena Cancer Institute, CRS, Rome, Italy
    Cancer Res 63:1430-7. 2003
    ..These findings suggest a common pathway of these oncoproteins in eliciting virus-induced genomic instability...
  27. ncbi request reprint Evaluation of antitumoral properties of the protease inhibitor indinavir in a murine model of hepatocarcinoma
    Vincenzo Esposito
    Third Division Cotugno Hospital, Naples, Italy
    Clin Cancer Res 12:2634-9. 2006
    ..We aimed to evaluate the antineoplastic potential activities of the protease inhibitor indinavir (Crixivan) in in vitro and in vivo hepatocarcinoma models...
  28. ncbi request reprint Down-regulation of aquaporin 4 in human placenta throughout pregnancy
    Maria De Falco
    Department of Biological Sciences, Section of Evolutionary and Comparative Biology, University of Naples Federico II, Naples, Italy
    In Vivo 21:813-7. 2007
    ..To date, the regulation of AQP4 expression in the human placenta has not been studied. The purpose of this work was to investigate AQP4 localization and expression in the human placenta during gestation...
  29. ncbi request reprint Distribution of apelin, the endogenous ligand of the APJ receptor, in the lizard Podarcis sicula
    Maria De Falco
    Department of Evolution and Comparative Biology, Federico II University, Naples, Italy
    J Mol Histol 35:521-7. 2004
    ..Intriguingly, apelin immunoreactivity was discretely localized in endothelial cells in the lung and thyroid gland. In the light of these data, we conclude that apelin may have multiple functions in reptiles...
  30. ncbi request reprint The serine protease HtrA1 is upregulated in the human placenta during pregnancy
    Antonio De Luca
    Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Italy
    J Histochem Cytochem 52:885-92. 2004
    ....
  31. ncbi request reprint cDNA array technology in melanoma: an overview
    Alfonso Baldi
    Regina Elena Cancer Institute, CRS, Via delle Messi d oro, Rome, Italy
    J Cell Physiol 196:219-23. 2003
    ..This review discusses some recent findings obtained by means of cDNA arrays investigating the human melanoma...
  32. ncbi request reprint Identification of genes down-regulated during melanoma progression: a cDNA array study
    Alfonso Baldi
    Laboratory C, Department for the Development of Therapeutic Programs, Center for Experimental Research, Regina Elena Cancer Institute, Rome, Italy
    Exp Dermatol 12:213-8. 2003
    ..In conclusion, comparative hybridization by means of cDNA arrays assisted in identifying a series of novel progression-associated changes in gene expression, confirming, at the same time, a number of previously described results...
  33. pmc Tumor suppressors and cell-cycle proteins in lung cancer
    Alfonso Baldi
    Section of Pathology, Department of Biochemistry, Second University of Naples, 80138 Naples, Italy
    Patholog Res Int 2011:605042. 2011
    ..Finally, based essentially on the data generated in our laboratory, the expression, the diagnostic, and prognostic significance of cell-cycle molecules in lung cancer will be examined...
  34. ncbi request reprint Cell cycle as a target of antineoplastic drugs
    Maria De Falco
    School of Medicine, Second University of Naples Via L Armanni, 5, 80138 Naples, Italy
    Curr Pharm Des 16:1417-26. 2010
    ..Starting from a description of cell cycle, this review summarizes the most recent studies on drugs targeting cell cycle regulators that are being used in cancer therapy...
  35. ncbi request reprint Helicobacter pylori and gastric diseases: a dangerous association
    Antonio De Luca
    Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Naples, Italy
    Cancer Lett 213:1-10. 2004
    ..Due to dangerous infection of this bacterium, the scientific community must point out its attention on the development of detection and prevention strategies...
  36. ncbi request reprint p27kip1 overexpression promotes paclitaxel-induced apoptosis in pRb-defective SaOs-2 cells
    Chiara Gabellini
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy
    J Cell Biochem 98:1645-52. 2006
    ..The promoting effect of p27kip1 overexpression on apoptosis makes p27kip1 and proteasomal inhibitors interesting tools for therapy in patients with pRb-defective cancers...
  37. ncbi request reprint Apelin expression in normal human tissues
    Maria De Falco
    Department of Evolutive and Comparative Biology, University Federico II, Naples, Italy
    In Vivo 16:333-6. 2002
    ..These results seem to confirm that apelin functions widely in various tissues interacting with its specific receptor APJ...
  38. ncbi request reprint Endothelin-B (ET(B)) receptor distribution in tissues of the lizard Podarcis sicula
    Maria De Falco
    Department of Evolutive and Comparative Biology, University of Naples Federico II, Naples, Italy
    Cell Tissue Res 309:381-6. 2002
    ..On the other hand, the presence of ET(B) immunoreactivity also in endocrine systems such as adrenal and thyroid glands suggests an involvement also in the paracrine system of these organs...
  39. ncbi request reprint Loss of pRb2/p130 expression is associated with unfavorable clinical outcome in lung cancer
    Mario Caputi
    Department of Medical Surgical, Cardiological, Respiratory, and Thoracic Sciences, Second University of Naples, Naples, Italy
    Clin Cancer Res 8:3850-6. 2002
    ..pRb2/p130 immunoreactivity can be used to predict OS in patients with NSCLC and, therefore, may represent a new prognostic marker...
  40. ncbi request reprint Cyclin T: three forms for different roles in physiological and pathological functions
    Antonio De Luca
    Laboratory C, Department for the Development of Therapeutic Programs, Center for Experimental Research, Regina Elena Cancer Institute, Rome, Italy
    J Cell Physiol 194:101-7. 2003
    ..On the other hand, CDK9/cyclin T2 complexes are involved in the regulation of terminal differentiation in muscle cells...
  41. ncbi request reprint Proliferation of cardiomyocytes: a question unresolved
    Maria De Falco
    Department of Biological Sciences, Section of Evolutionary and Comparative Biology, University Federico II of Naples, Naples, Italy
    Front Biosci (Elite Ed) 1:528-36. 2009
    ..In this view, the understanding of main candidates regulating cardiomyocyte cell cycle is of vital importance for future clinical approach...
  42. ncbi request reprint Mid-trimester fetal-placental velocimetry response to nifedipine may predict early the onset of pre-eclampsia
    Luigi Cobellis
    Department of Gynaecology, Obstetrics and Reproduction, Second University of Naples, Naples, Italy
    In Vivo 20:183-6. 2006
    ..09 to 2.31+/- 0.09) arteries and the middle cerebral PI (from 1.45 +/- 0.03 to 1.61 +/- 0.01) artery only in PIH, but not in PE patients. Fetal-placental blood flow changes after nifedipine may early identify patients at risk of PE...
  43. ncbi request reprint Cardiovascular prosthetic surgery: an analysis of cellular and molecular patterns underlying valve implantation failure
    Gennaro Mazzarella
    Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, Naples, Italy
    In Vivo 26:271-5. 2012
    ..Finally we also tried to assess not only the degree of endothelial layer loss, but also the extent of revascularization in the exuberant fibrous tissue...
  44. ncbi request reprint The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells
    Alfonso Baldi
    Laboratory C, CRS, Regina Elena Cancer Institute, Rome, Italy
    Oncogene 21:6684-8. 2002
    ..These results suggest that down-regulation of PRSS11 and HtrA1 expression may represent an indicator of melanoma progression...
  45. ncbi request reprint Cystic nephroma: report of a case and review of the literature
    Alfonso Baldi
    Department of Biochemistry, Section of Pathology, Second University of Naples, Via L Armanni 5, 80138 Naples, Italy
    In Vivo 21:895-6. 2007
    ..The histopathological differential diagnosis and immunohistochemical features that are potentially useful for refining this tumor are discussed...
  46. ncbi request reprint Meeting report on the 12th International Congress of Histochemistry and Cytochemistry (ICHC)
    Maria De Falco
    Department of Evolutionary and Comparative Biology, University of Naples Federico II, Naples, Italy
    J Cell Physiol 204:407-11. 2005
    ..A summary of the last meeting is reported...
  47. ncbi request reprint Biochemical and immunohistochemical evidence for a non-muscle myosin at the neuromuscular junction in bovine skeletal muscle
    Elena Pompili
    Department of Cardiovascular Sciences, University La Sapienza, Rome, Italy
    J Histochem Cytochem 51:471-8. 2003
    ..Because of the above biochemical and immunohistochemical features, the 220-kD protein we have identified is suggested to be a novel member of the non-muscle (non-sarcomeric) myosin family...
  48. pmc Rapid identification of Candida species in oral rinse solutions by PCR
    Giorgio Liguori
    Chair of Hygiene and Epidemiology, Faculty of Movement Sciences, University of Naples Parthenope, Naples, Italy
    J Clin Pathol 60:1035-9. 2007
    ....
  49. ncbi request reprint Deacetylase recruitment by the C/H3 domain of the acetyltransferase p300
    Cristiano Simone
    Laboratory of Gene Expression, Dulbecco Telethon Institute DTI at Fondazione A Cesalpino, University of Roma La Sapienza, Italy
    Oncogene 23:2177-87. 2004
    ....
  50. ncbi request reprint Electron microscopy characterization of cardiomyocyte apoptosis in ischemic heart disease
    Antonio Abbate
    Int J Cardiol 114:118-20. 2007
  51. ncbi request reprint Different patterns of expression of five neuropeptides in the adrenal gland and kidney of two species of frog
    Maria De Falco
    Department of Evolutive and Comparative Biology, Naples University Federico II, Italy
    Histochem J 34:21-6. 2002
    ..A strong positivity was also observed in kidney in both frogs. These observations suggest a possible role of these peptides in the control of the physiological functions of adrenal glands and kidney of the two species of frogs studied...