Annamaria De Bellis

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. doi request reprint Involvement of hypothalamus autoimmunity in patients with autoimmune hypopituitarism: role of antibodies to hypothalamic cells
    A De Bellis
    Department of Cardiothoracic and Respiratory Sciences, Second University of Naples via Pansini N 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 97:3684-90. 2012
  2. ncbi request reprint Antipituitary antibodies against gonadotropin-secreting cells in adult male patients with apparently idiopathic hypogonadotropic hypogonadism
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, Naples, Italy
    J Clin Endocrinol Metab 92:604-7. 2007
  3. ncbi request reprint Prolactin and autoimmunity
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, via Pansini N 5, 80131, Napoli, Italy
    Pituitary 8:25-30. 2005
  4. ncbi request reprint Antipituitary antibodies recognizing growth hormone (GH)-producing cells in children with idiopathic GH deficiency and in children with idiopathic short stature
    Annamaria De Bellis
    Chair of Endocrinology, Second University of Naples, Via S Pansini, 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 91:2484-9. 2006
  5. doi request reprint Detection of antipituitary and antihypothalamus antibodies to investigate the role of pituitary or hypothalamic autoimmunity in patients with selective idiopathic hypopituitarism
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 75:361-6. 2011
  6. ncbi request reprint Autoimmunity as a possible cause of growth hormone deficiency
    A De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, Naples, Italy
    J Endocrinol Invest 31:1132-4. 2008
  7. ncbi request reprint Antipituitary antibodies in idiopathic hyperprolactinemic patients
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, Naples, Italy
    Ann N Y Acad Sci 1107:129-35. 2007
  8. doi request reprint Effect of long-term cabergoline therapy on the immunological pattern and pituitary function of patients with idiopathic hyperprolactinaemia positive for antipituitary antibodies
    A De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, Italy
    Clin Endocrinol (Oxf) 69:285-91. 2008
  9. doi request reprint Anti-hypothalamus and anti-pituitary antibodies may contribute to perpetuate the hypopituitarism in patients with Sheehan's syndrome
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, via Pansini N 5, 80131 Napoli, Italy
    Eur J Endocrinol 158:147-52. 2008
  10. doi request reprint Immunological and clinical aspects of lymphocytic hypophysitis
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, Naples 80131, Italy
    Clin Sci (Lond) 114:413-21. 2008

Collaborators

Detail Information

Publications35

  1. doi request reprint Involvement of hypothalamus autoimmunity in patients with autoimmune hypopituitarism: role of antibodies to hypothalamic cells
    A De Bellis
    Department of Cardiothoracic and Respiratory Sciences, Second University of Naples via Pansini N 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 97:3684-90. 2012
    ..Antipituitary antibodies (APA) but not antihypothalamus antibodies (AHA) are usually searched for in autoimmune hypopituitarism...
  2. ncbi request reprint Antipituitary antibodies against gonadotropin-secreting cells in adult male patients with apparently idiopathic hypogonadotropic hypogonadism
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, Naples, Italy
    J Clin Endocrinol Metab 92:604-7. 2007
    ..However, the defect in patients with idiopathic HH is still unknown...
  3. ncbi request reprint Prolactin and autoimmunity
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, via Pansini N 5, 80131, Napoli, Italy
    Pituitary 8:25-30. 2005
    ..Finally, the role of anti-prolactinemic drugs to inactivate the immune process in LYH is still discussed...
  4. ncbi request reprint Antipituitary antibodies recognizing growth hormone (GH)-producing cells in children with idiopathic GH deficiency and in children with idiopathic short stature
    Annamaria De Bellis
    Chair of Endocrinology, Second University of Naples, Via S Pansini, 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 91:2484-9. 2006
    ..Antipituitary antibodies (APA) recognizing GH-secreting cells may indicate an autoimmune pituitary involvement in adults with idiopathic GH deficiency (IGHD)...
  5. doi request reprint Detection of antipituitary and antihypothalamus antibodies to investigate the role of pituitary or hypothalamic autoimmunity in patients with selective idiopathic hypopituitarism
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 75:361-6. 2011
    ..This study searched for APA and AHA in some of these patients to investigate whether pituitary or hypothalamic autoimmunity could play a role in their pituitary dysfunction...
  6. ncbi request reprint Autoimmunity as a possible cause of growth hormone deficiency
    A De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, Naples, Italy
    J Endocrinol Invest 31:1132-4. 2008
    ..In this connection we suggested that in these patients an early iso-hormonal therapy with recombinant GH may be useful to interrupt or delay the progression towards a clinical GHD...
  7. ncbi request reprint Antipituitary antibodies in idiopathic hyperprolactinemic patients
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, Naples, Italy
    Ann N Y Acad Sci 1107:129-35. 2007
    ..A future longitudinal study of these patients submitted to cabergoline therapy or free of therapy may be helpful to clarify this assumption...
  8. doi request reprint Effect of long-term cabergoline therapy on the immunological pattern and pituitary function of patients with idiopathic hyperprolactinaemia positive for antipituitary antibodies
    A De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, Italy
    Clin Endocrinol (Oxf) 69:285-91. 2008
    ..This longitudinal study was aimed at investigating, in patients with IH the occurrence of APA and the effect of cabergoline on the pituitary function and behaviour of APA...
  9. doi request reprint Anti-hypothalamus and anti-pituitary antibodies may contribute to perpetuate the hypopituitarism in patients with Sheehan's syndrome
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, via Pansini N 5, 80131 Napoli, Italy
    Eur J Endocrinol 158:147-52. 2008
    ....
  10. doi request reprint Immunological and clinical aspects of lymphocytic hypophysitis
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, Naples 80131, Italy
    Clin Sci (Lond) 114:413-21. 2008
    ..In addition, although the mechanisms underlying LYH are not completely understood, the role of prolactin, which plays an important part in maintaining immune system homoeostasis and is increased in the disease, is considered...
  11. ncbi request reprint Characterization of antipituitary antibodies targeting pituitary hormone-secreting cells in idiopathic growth hormone deficiency and autoimmune endocrine diseases
    Annamaria De Bellis
    Chair of Endocrinology, Department of Clinical and Experimental Medicine and Surgery F Magrassi and A Lanzara Second University of Naples, 80131, Naples, Italy
    Clin Endocrinol (Oxf) 63:45-9. 2005
    ..In order to investigate whether somatotrophs are the target of antipituitary antibodies (APA) in adult patients with growth hormone deficiency (GHD), we studied the sera of 37 APA positive patients...
  12. ncbi request reprint Pituitary antibodies and lymphocytic hypophysitis
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, via Pansini N 5, Napoli 80131, Italy
    Best Pract Res Clin Endocrinol Metab 19:67-84. 2005
    ..The results suggest that only when they are present at high titres may they be considered a good marker of pituitary involvement, and in particular of growth-hormone-producing cells...
  13. ncbi request reprint Serum antibodies to collagen XIII: a further good marker of active Graves' ophthalmopathy
    A De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi and A Lanzara, Second University of Naples, Italy
    Clin Endocrinol (Oxf) 62:24-9. 2005
    ..The aim of this study was to search for CollXIIIAb in Graves' patients with and without ophthalmopathy and to correlate their levels with CAS and with serum soluble ICAM-1 (sICAM-1) values...
  14. ncbi request reprint Antipituitary antibodies in adults with apparently idiopathic growth hormone deficiency and in adults with autoimmune endocrine diseases
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 88:650-4. 2003
    ..Moreover, they may indicate an autoimmune pituitary involvement in adults with apparently idiopathic GHD, suggesting that the prevalence of autoimmune GHD is much higher than that so far considered...
  15. ncbi request reprint Extraocular muscle antibodies and the occurrence of ophthalmopathy in Graves' disease
    A De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi and A Lanzara, Second University of Naples, Italy
    Clin Endocrinol (Oxf) 60:694-8. 2004
    ....
  16. ncbi request reprint Relationship between longitudinal behaviour of some markers of eye autoimmunity and changes in ocular findings in patients with Graves' ophthalmopathy receiving corticosteroid therapy
    Annamaria De Bellis
    Chair of Endocrinology, Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, Italy
    Clin Endocrinol (Oxf) 59:388-95. 2003
    ....
  17. doi request reprint Time course of Graves' ophthalmopathy after total thyroidectomy alone or followed by radioiodine therapy: a 2-year longitudinal study
    Annamaria De Bellis
    Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, via Pansini N 5, 80131 Naples, Italy
    Endocrine 41:320-6. 2012
    ..Our results suggest that in Graves' patients with large goiter or relapse of hyperthyroidism and mild/moderate GO, TT alone could be an advisable choice to treat hyperthyroidism also improving GO with reduction of cost/benefit ratio...
  18. doi request reprint Predictive role of the immunostaining pattern of immunofluorescence and the titers of antipituitary antibodies at presentation for the occurrence of autoimmune hypopituitarism in patients with autoimmune polyendocrine syndromes over a five-year follow-up
    Giuseppe Bellastella
    Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, via Pansini N 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 95:3750-7. 2010
    ..Antipituitary antibodies (APA) are frequently present in patients with autoimmune polyendocrine syndrome (APS)...
  19. ncbi request reprint Lymphocytic hypophysitis: a rare or underestimated disease?
    Antonio Bellastella
    Chair of Endocrinology, Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, 5 Via S Pansini, 80131 Naples, Italy
    Eur J Endocrinol 149:363-76. 2003
    ..Medical (immunosuppressive, replacement and antiprolactinemic) and neurosurgical (decompression) treatments are needed in clinical symptomatic patients...
  20. doi request reprint Subclinical diabetes insipidus
    Antonio Bellastella
    Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, Via Leonardo Bianchi, Monaldi Hospital, 80131 Naples, Italy
    Best Pract Res Clin Endocrinol Metab 26:471-83. 2012
    ..Several medical treatments have been suggested to interrupt the progression toward clinical CDI but the results are still discussed...
  21. doi request reprint Expression of RIZ1 protein (Retinoblastoma-interacting zinc-finger protein 1) in prostate cancer epithelial cells changes with cancer grade progression and is modulated in vitro by DHT and E2
    Valentina Rossi
    Dipartimento di Internistica Clinica e Sperimentale, Sezione di Endocrinologia, Seconda Universita degli Studi di Napoli, Napoli, Italy
    J Cell Physiol 221:771-7. 2009
    ..Furthermore, the E2 effects on ER-expressing prostate cells involve RIZ1, which confirms a possible role for ER-mediated pathways in a non-classic E(2)-target tissue...
  22. ncbi request reprint Fenofibrate increases the expression of high mobility group AT-hook 2 (HMGA2) gene and induces adipocyte differentiation of orbital fibroblasts from Graves' ophthalmopathy
    Daniela Pasquali
    Section of Endocrinology, Medico Surgical Department of Clinical and Experimental Internal Medicine F Magrassi e A Lanzara, Research Center for Cardiovascular Disease, Second University of Naples, Naples, Italy
    J Mol Endocrinol 33:133-43. 2004
    ..These findings suggest that novel drugs to antagonize PPARalpha, other than the PPARgamma signalling system, may also need to be considered in the treatment or prevention of Graves' ophthalmopathy...
  23. doi request reprint Homozygous mutation in the prokineticin-receptor2 gene (Val274Asp) presenting as reversible Kallmann syndrome and persistent oligozoospermia: case report
    Antonio Agostino Sinisi
    Department of Clinical and Experimental Medicine and Surgery, Endocrinology and Medical Andrology Section, Seconda Universita di Napoli, Napoli, Italy
    Hum Reprod 23:2380-4. 2008
    ....
  24. doi request reprint Late primary autoimmune hypothyroidism in a patient with postdelivery autoimmune hypopituitarism associated with antibodies to growth hormone and prolactin-secreting cells
    Annamaria De Bellis
    Department of Cardiothoracic and Respiratory Sciences, Section of Endocrinology, Faculty of Medicine and Surgery, Second University of Naples, Naples, Italy
    Thyroid 23:1037-41. 2013
    ....
  25. doi request reprint Effects of somatostatin analog SOM230 on cell proliferation, apoptosis, and catecholamine levels in cultured pheochromocytoma cells
    Daniela Pasquali
    Endocrine Unit, Department of Clinical and Experimental Medicine and Surgery and Endo Surgery Unit, Second University of Naples, 80131 Naples
    J Mol Endocrinol 40:263-71. 2008
    ..This improves our knowledge on the mechanism of SOM230 action in PHEO and supports a possible therapeutic use in benign PHEO recurrence...
  26. doi request reprint Total thyroidectomy, without prophylactic central lymph node dissection, in the treatment of differentiated thyroid cancer. Clinical retrospective study on 221 cases
    Giovanni Conzo
    Department of Anaesthesiologic, Surgical and Emergency Science, VII Division of General and Endocrine Surgery, Second University of Naples, Via Pansini 5, Build 17, 80131, Naples, Italy
    Endocrine 44:419-25. 2013
    ..However, given the trend in the literature toward prophylactic lymphadenectomy and the avoidance of RAI treatment, prospective randomized trials should be conducted to better clarify this issue...
  27. doi request reprint Antipituitary antibodies after traumatic brain injury: is head trauma-induced pituitary dysfunction associated with autoimmunity?
    Fatih Tanriverdi
    Department of Endocrinology, Erciyes University Medical School, 38039 Kayseri, Turkey
    Eur J Endocrinol 159:7-13. 2008
    ....
  28. ncbi request reprint Central diabetes insipidus and autoimmunity: relationship between the occurrence of antibodies to arginine vasopressin-secreting cells and clinical, immunological, and radiological features in a large cohort of patients with central diabetes insipidus of
    Rosario Pivonello
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 88:1629-36. 2003
    ..Conversely, autoimmunity probably represents an epiphenomenon in patients with nonidiopathic CDI...
  29. ncbi request reprint Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity
    Alberto Falorni
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Fertil Steril 78:270-9. 2002
    ..To determine the prevalence of steroid-cell autoantibodies, 3beta-hydroxysteroid dehydrogenase (3beta-HSD) antibodies, 17alpha-hydroxylase (17alpha-OH) antibodies, and P450 side-chain cleavage antibodies in premature ovarian failure...
  30. ncbi request reprint Growth hormone impaired secretion and antipituitary antibodies in patients with coeliac disease and poor catch-up growth after a long gluten-free diet period: a causal association?
    Lorenzo Iughetti
    Department of Pediatrics, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41 100, Modena, Italy
    Eur J Pediatr 165:897-903. 2006
    ..Seven CD children, without catch-up growth after at least 12-months GFD, were tested for GH secretion and, in five out of seven patients, the diagnosis of GHD was made in the absence of metabolic and systemic diseases...
  31. ncbi request reprint Idiopathic central diabetes insipidus in children and young adults is commonly associated with vasopressin-cell antibodies and markers of autoimmunity
    Mohamad Maghnie
    Department of Paediatrics, IRCCS G Gaslini Institute, University of Genova, Italy
    Clin Endocrinol (Oxf) 65:470-8. 2006
    ..Autoimmune targeting of hypothalamic-neurohypophyseal structures in children and young adults with posterior pituitary and anterior pituitary dysfunction, as well as pituitary stalk involvement, are not yet completely understood...
  32. ncbi request reprint Elevated serum interferon-gamma-inducible chemokine-10/CXC chemokine ligand-10 in autoimmune primary adrenal insufficiency and in vitro expression in human adrenal cells primary cultures after stimulation with proinflammatory cytokines
    Mario Rotondi
    Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, V le Pieraccini 6, 50139 Firenze, Italy
    J Clin Endocrinol Metab 90:2357-63. 2005
    ..Taken together, these data suggest a potential role of hZFC, through the production of CXCL10, in regulating the recruitment of specific subsets of activated lymphocytes in autoimmune AD...
  33. ncbi request reprint Italian addison network study: update of diagnostic criteria for the etiological classification of primary adrenal insufficiency
    Alberto Falorni
    Department of Internal Medicine, University of Perugia, 06126 Perugia, Italy
    J Clin Endocrinol Metab 89:1598-604. 2004
    ..Lastly, we developed a comprehensive flowchart for the classification of PAI for use in routine clinical practice...
  34. ncbi request reprint Mapping of human autoantibody epitopes on aromatic L-amino acid decarboxylase
    Paola Candeloro
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, Via E dal Pozzo, 06126 Perugia, Italy
    J Clin Endocrinol Metab 92:1096-105. 2007
    ..Little information is currently available on AADC autoantibody epitopes and on the interrelation between autoantibody-mediated inhibition of enzymatic activity and epitope specificity...
  35. ncbi request reprint MHC2TA single nucleotide polymorphism and genetic risk for autoimmune adrenal insufficiency
    Mehran Ghaderi
    Department of Clinical Pathology and Cytology, Karolinska University Hospital, SE 141 86 Stockholm, Sweden
    J Clin Endocrinol Metab 91:4107-11. 2006
    ..The MHC2TA -168 A-->G single nucleotide polymorphism (rs3087456) has been suggested to confer susceptibility to some autoimmune diseases...