Research Topics
Species | Annamaria De BellisSummaryAffiliation: Second University of Naples Country: Italy Publications
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Detail Information
Publications
Involvement of hypothalamus autoimmunity in patients with autoimmune hypopituitarism: role of antibodies to hypothalamic cellsA De Bellis
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples via Pansini N 5, 80131 Naples, Italy
J Clin Endocrinol Metab 97:3684-90. 2012..Antipituitary antibodies (APA) but not antihypothalamus antibodies (AHA) are usually searched for in autoimmune hypopituitarism...
Prolactin and autoimmunityAnnamaria De Bellis
Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, via Pansini N 5, 80131, Napoli, Italy
Pituitary 8:25-30. 2005..Finally, the role of anti-prolactinemic drugs to inactivate the immune process in LYH is still discussed...- Antipituitary antibodies against gonadotropin-secreting cells in adult male patients with apparently idiopathic hypogonadotropic hypogonadismAnnamaria De Bellis
Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, Naples, Italy
J Clin Endocrinol Metab 92:604-7. 2007..However, the defect in patients with idiopathic HH is still unknown... - Autoimmunity as a possible cause of growth hormone deficiencyA De Bellis
Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, Naples, Italy
J Endocrinol Invest 31:1132-4. 2008..In this connection we suggested that in these patients an early iso-hormonal therapy with recombinant GH may be useful to interrupt or delay the progression towards a clinical GHD... - Effect of long-term cabergoline therapy on the immunological pattern and pituitary function of patients with idiopathic hyperprolactinaemia positive for antipituitary antibodiesA De Bellis
Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, Italy
Clin Endocrinol (Oxf) 69:285-91. 2008..This longitudinal study was aimed at investigating, in patients with IH the occurrence of APA and the effect of cabergoline on the pituitary function and behaviour of APA... - Antipituitary antibodies recognizing growth hormone (GH)-producing cells in children with idiopathic GH deficiency and in children with idiopathic short statureAnnamaria De Bellis
Chair of Endocrinology, Second University of Naples, Via S Pansini, 5, 80131 Naples, Italy
J Clin Endocrinol Metab 91:2484-9. 2006..Antipituitary antibodies (APA) recognizing GH-secreting cells may indicate an autoimmune pituitary involvement in adults with idiopathic GH deficiency (IGHD)... - Anti-hypothalamus and anti-pituitary antibodies may contribute to perpetuate the hypopituitarism in patients with Sheehan's syndromeAnnamaria De Bellis
Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, via Pansini N 5, 80131 Napoli, Italy
Eur J Endocrinol 158:147-52. 2008.... - Characterization of antipituitary antibodies targeting pituitary hormone-secreting cells in idiopathic growth hormone deficiency and autoimmune endocrine diseasesAnnamaria De Bellis
Chair of Endocrinology, Department of Clinical and Experimental Medicine and Surgery F Magrassi and A Lanzara Second University of Naples, 80131, Naples, Italy
Clin Endocrinol (Oxf) 63:45-9. 2005..In order to investigate whether somatotrophs are the target of antipituitary antibodies (APA) in adult patients with growth hormone deficiency (GHD), we studied the sera of 37 APA positive patients... - Pituitary antibodies and lymphocytic hypophysitisAnnamaria De Bellis
Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, via Pansini N 5, Napoli 80131, Italy
Best Pract Res Clin Endocrinol Metab 19:67-84. 2005..The results suggest that only when they are present at high titres may they be considered a good marker of pituitary involvement, and in particular of growth-hormone-producing cells... - Detection of antipituitary and antihypothalamus antibodies to investigate the role of pituitary or hypothalamic autoimmunity in patients with selective idiopathic hypopituitarismAnnamaria De Bellis
Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, Naples, Italy
Clin Endocrinol (Oxf) 75:361-6. 2011..This study searched for APA and AHA in some of these patients to investigate whether pituitary or hypothalamic autoimmunity could play a role in their pituitary dysfunction... - Serum antibodies to collagen XIII: a further good marker of active Graves' ophthalmopathyA De Bellis
Department of Clinical and Experimental Medicine and Surgery F Magrassi and A Lanzara, Second University of Naples, Italy
Clin Endocrinol (Oxf) 62:24-9. 2005..The aim of this study was to search for CollXIIIAb in Graves' patients with and without ophthalmopathy and to correlate their levels with CAS and with serum soluble ICAM-1 (sICAM-1) values... - Immunological and clinical aspects of lymphocytic hypophysitisAnnamaria De Bellis
Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, Naples 80131, Italy
Clin Sci (Lond) 114:413-21. 2008..In addition, although the mechanisms underlying LYH are not completely understood, the role of prolactin, which plays an important part in maintaining immune system homoeostasis and is increased in the disease, is considered... - Extraocular muscle antibodies and the occurrence of ophthalmopathy in Graves' diseaseA De Bellis
Department of Clinical and Experimental Medicine and Surgery F Magrassi and A Lanzara, Second University of Naples, Italy
Clin Endocrinol (Oxf) 60:694-8. 2004.... - Relationship between longitudinal behaviour of some markers of eye autoimmunity and changes in ocular findings in patients with Graves' ophthalmopathy receiving corticosteroid therapyAnnamaria De Bellis
Chair of Endocrinology, Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, Italy
Clin Endocrinol (Oxf) 59:388-95. 2003.... - Antipituitary antibodies in adults with apparently idiopathic growth hormone deficiency and in adults with autoimmune endocrine diseasesAnnamaria De Bellis
Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, 80131 Naples, Italy
J Clin Endocrinol Metab 88:650-4. 2003..Moreover, they may indicate an autoimmune pituitary involvement in adults with apparently idiopathic GHD, suggesting that the prevalence of autoimmune GHD is much higher than that so far considered... - Antipituitary antibodies in idiopathic hyperprolactinemic patientsAnnamaria De Bellis
Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, Naples, Italy
Ann N Y Acad Sci 1107:129-35. 2007..A future longitudinal study of these patients submitted to cabergoline therapy or free of therapy may be helpful to clarify this assumption... - Time course of Graves' ophthalmopathy after total thyroidectomy alone or followed by radioiodine therapy: a 2-year longitudinal studyAnnamaria De Bellis
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, via Pansini N 5, 80131 Naples, Italy
Endocrine 41:320-6. 2012..Our results suggest that in Graves' patients with large goiter or relapse of hyperthyroidism and mild/moderate GO, TT alone could be an advisable choice to treat hyperthyroidism also improving GO with reduction of cost/benefit ratio... - Predictive role of the immunostaining pattern of immunofluorescence and the titers of antipituitary antibodies at presentation for the occurrence of autoimmune hypopituitarism in patients with autoimmune polyendocrine syndromes over a five-year follow-upGiuseppe Bellastella
Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, via Pansini N 5, 80131 Naples, Italy
J Clin Endocrinol Metab 95:3750-7. 2010..Antipituitary antibodies (APA) are frequently present in patients with autoimmune polyendocrine syndrome (APS)... - Lymphocytic hypophysitis: a rare or underestimated disease?Antonio Bellastella
Chair of Endocrinology, Department of Clinical and Experimental Medicine and Surgery, F Magrassi, A Lanzara, Second University of Naples, 5 Via S Pansini, 80131 Naples, Italy
Eur J Endocrinol 149:363-76. 2003..Medical (immunosuppressive, replacement and antiprolactinemic) and neurosurgical (decompression) treatments are needed in clinical symptomatic patients... - Subclinical diabetes insipidusAntonio Bellastella
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, Via Leonardo Bianchi, Monaldi Hospital, 80131 Naples, Italy
Best Pract Res Clin Endocrinol Metab 26:471-83. 2012..Several medical treatments have been suggested to interrupt the progression toward clinical CDI but the results are still discussed... - Homozygous mutation in the prokineticin-receptor2 gene (Val274Asp) presenting as reversible Kallmann syndrome and persistent oligozoospermia: case reportAntonio Agostino Sinisi
Department of Clinical and Experimental Medicine and Surgery, Endocrinology and Medical Andrology Section, Seconda Universita di Napoli, Napoli, Italy
Hum Reprod 23:2380-4. 2008.... - Expression of RIZ1 protein (Retinoblastoma-interacting zinc-finger protein 1) in prostate cancer epithelial cells changes with cancer grade progression and is modulated in vitro by DHT and E2Valentina Rossi
Dipartimento di Internistica Clinica e Sperimentale, Sezione di Endocrinologia, Seconda Universita degli Studi di Napoli, Napoli, Italy
J Cell Physiol 221:771-7. 2009..Furthermore, the E2 effects on ER-expressing prostate cells involve RIZ1, which confirms a possible role for ER-mediated pathways in a non-classic E(2)-target tissue... - Fenofibrate increases the expression of high mobility group AT-hook 2 (HMGA2) gene and induces adipocyte differentiation of orbital fibroblasts from Graves' ophthalmopathyDaniela Pasquali
Section of Endocrinology, Medico-Surgical Department of Clinical and Experimental Internal Medicine 'F. Magrassi e A. Lanzara, Research Center for Cardiovascular Disease, Second University of Naples, Naples, Italy
J Mol Endocrinol 33:133-43. 2004..These findings suggest that novel drugs to antagonize PPARalpha, other than the PPARgamma signalling system, may also need to be considered in the treatment or prevention of Graves' ophthalmopathy... - Effects of somatostatin analog SOM230 on cell proliferation, apoptosis, and catecholamine levels in cultured pheochromocytoma cellsDaniela Pasquali
Endocrine Unit, Department of Clinical and Experimental Medicine and Surgery and Endo Surgery Unit, Second University of Naples, 80131 Naples
J Mol Endocrinol 40:263-71. 2008..This improves our knowledge on the mechanism of SOM230 action in PHEO and supports a possible therapeutic use in benign PHEO recurrence... - Antipituitary antibodies after traumatic brain injury: is head trauma-induced pituitary dysfunction associated with autoimmunity?Fatih Tanriverdi
Department of Endocrinology, Erciyes University Medical School, 38039 Kayseri, Turkey
Eur J Endocrinol 159:7-13. 2008.... - Idiopathic central diabetes insipidus in children and young adults is commonly associated with vasopressin-cell antibodies and markers of autoimmunityMohamad Maghnie
Department of Paediatrics, IRCCS G Gaslini Institute, University of Genova, Italy
Clin Endocrinol (Oxf) 65:470-8. 2006..Autoimmune targeting of hypothalamic-neurohypophyseal structures in children and young adults with posterior pituitary and anterior pituitary dysfunction, as well as pituitary stalk involvement, are not yet completely understood... - Growth hormone impaired secretion and antipituitary antibodies in patients with coeliac disease and poor catch-up growth after a long gluten-free diet period: a causal association?Lorenzo Iughetti
Department of Pediatrics, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41 100, Modena, Italy
Eur J Pediatr 165:897-903. 2006..Seven CD children, without catch-up growth after at least 12-months GFD, were tested for GH secretion and, in five out of seven patients, the diagnosis of GHD was made in the absence of metabolic and systemic diseases... - Central diabetes insipidus and autoimmunity: relationship between the occurrence of antibodies to arginine vasopressin-secreting cells and clinical, immunological, and radiological features in a large cohort of patients with central diabetes insipidus of Rosario Pivonello
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
J Clin Endocrinol Metab 88:1629-36. 2003..Conversely, autoimmunity probably represents an epiphenomenon in patients with nonidiopathic CDI... - Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunityAlberto Falorni
Department of Internal Medicine, University of Perugia, Perugia, Italy
Fertil Steril 78:270-9. 2002..To determine the prevalence of steroid-cell autoantibodies, 3beta-hydroxysteroid dehydrogenase (3beta-HSD) antibodies, 17alpha-hydroxylase (17alpha-OH) antibodies, and P450 side-chain cleavage antibodies in premature ovarian failure... - Mapping of human autoantibody epitopes on aromatic L-amino acid decarboxylasePaola Candeloro
Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, Via E dal Pozzo, 06126 Perugia, Italy
J Clin Endocrinol Metab 92:1096-105. 2007..Little information is currently available on AADC autoantibody epitopes and on the interrelation between autoantibody-mediated inhibition of enzymatic activity and epitope specificity... - MHC2TA single nucleotide polymorphism and genetic risk for autoimmune adrenal insufficiencyMehran Ghaderi
Department of Clinical Pathology and Cytology, Karolinska University Hospital, SE 141 86 Stockholm, Sweden
J Clin Endocrinol Metab 91:4107-11. 2006..The MHC2TA -168 A-->G single nucleotide polymorphism (rs3087456) has been suggested to confer susceptibility to some autoimmune diseases... - Elevated serum interferon-gamma-inducible chemokine-10/CXC chemokine ligand-10 in autoimmune primary adrenal insufficiency and in vitro expression in human adrenal cells primary cultures after stimulation with proinflammatory cytokinesMario Rotondi
Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, V. le Pieraccini 6, 50139 Firenze, Italy
J Clin Endocrinol Metab 90:2357-63. 2005..Taken together, these data suggest a potential role of hZFC, through the production of CXCL10, in regulating the recruitment of specific subsets of activated lymphocytes in autoimmune AD... - Italian addison network study: update of diagnostic criteria for the etiological classification of primary adrenal insufficiencyAlberto Falorni
Department of Internal Medicine, University of Perugia, 06126 Perugia, Italy
J Clin Endocrinol Metab 89:1598-604. 2004..Lastly, we developed a comprehensive flowchart for the classification of PAI for use in routine clinical practice...