Susan Costantini

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. ncbi request reprint Ascorbic Acid: its role in immune system and chronic inflammation diseases
    Angela Sorice
    Centro Ricerche Oncologiche di Mercogliano, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale, IRCCS, Italy
    Mini Rev Med Chem 14:444-52. 2014
  2. pmc Structural and functional similarities between osmotin from Nicotiana tabacum seeds and human adiponectin
    Marco Miele
    Department of Biochemistry and Biophysics and CRISCEB Interdepartmental Research Center for Computational and Biotechnological Sciences, Second University of Naples, Naples, Italy
    PLoS ONE 6:e16690. 2011
  3. pmc Interactomic and pharmacological insights on human sirt-1
    Ankush Sharma
    Research Center of Computational and Biotechnological Sciences, Second University of Naples Naples, Italy
    Front Pharmacol 3:40. 2012
  4. pmc Human sirt-1: molecular modeling and structure-function relationships of an unordered protein
    Ida Autiero
    CRISCEB Interdepartmental Research Center for Computational and Biotechnological Sciences Second University of Naples, Naples, Italy
    PLoS ONE 4:e7350. 2009
  5. pmc Modeling of the bacterial mechanism of methicillin-resistance by a systems biology approach
    Ida Autiero
    CRISCEB Interdepartmental Research Center for Computational and Biotechnological Sciences, Second University of Naples, Naples, Italy
    PLoS ONE 4:e6226. 2009
  6. doi request reprint A holistic approach to study the effects of natural antioxidants on inflammation and liver cancer
    Susan Costantini
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione Giovanni Pascale IRCCS Italia, via Ammiraglio Bianco, 83013, Mercogliano, Av, Italy
    Cancer Treat Res 159:311-23. 2014
  7. doi request reprint Common structural interactions between the receptors CXCR3, CXCR4 and CXCR7 complexed with their natural ligands, CXCL11 and CXCL12, by a modeling approach
    Susan Costantini
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione Giovanni Pascale, IRCCS, Italy Electronic address
    Cytokine 64:316-21. 2013
  8. doi request reprint Cancer biomarker profiling in patients with chronic hepatitis C virus, liver cirrhosis and hepatocellular carcinoma
    Susan Costantini
    National Cancer Institute G Pascale Foundation Oncology Research Center of Mercogliano CROM, Mercogliano, Italy
    Oncol Rep 29:2163-8. 2013
  9. pmc Genealogy of an ancient protein family: the Sirtuins, a family of disordered members
    Susan Costantini
    Pascale Foundation National Cancer Institute Cancer Research Center CROM, via Ammiraglio Bianco, 83013, Mercogliano, Italy
    BMC Evol Biol 13:60. 2013
  10. doi request reprint Gene expression signature of human HepG2 cell line
    S Costantini
    INT Pascale, Cancer Research Centre of Mercogliano, Mercogliano, Italy
    Gene 518:335-45. 2013

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Ascorbic Acid: its role in immune system and chronic inflammation diseases
    Angela Sorice
    Centro Ricerche Oncologiche di Mercogliano, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale, IRCCS, Italy
    Mini Rev Med Chem 14:444-52. 2014
    ..However, we propose that future studies will take into consideration the research of new combinations of antioxidant natural substances and drugs. ..
  2. pmc Structural and functional similarities between osmotin from Nicotiana tabacum seeds and human adiponectin
    Marco Miele
    Department of Biochemistry and Biophysics and CRISCEB Interdepartmental Research Center for Computational and Biotechnological Sciences, Second University of Naples, Naples, Italy
    PLoS ONE 6:e16690. 2011
    ..The biological effect on fibroblasts of osmotin and its peptide derivative has been found similar to that of adiponectin confirming the results found in silico...
  3. pmc Interactomic and pharmacological insights on human sirt-1
    Ankush Sharma
    Research Center of Computational and Biotechnological Sciences, Second University of Naples Naples, Italy
    Front Pharmacol 3:40. 2012
    ....
  4. pmc Human sirt-1: molecular modeling and structure-function relationships of an unordered protein
    Ida Autiero
    CRISCEB Interdepartmental Research Center for Computational and Biotechnological Sciences Second University of Naples, Naples, Italy
    PLoS ONE 4:e7350. 2009
    ..Its whole structure is not yet experimentally determined and the structural features of its allosteric site are unknown, and no information is known about the structural changes determined by the binding of its allosteric effectors...
  5. pmc Modeling of the bacterial mechanism of methicillin-resistance by a systems biology approach
    Ida Autiero
    CRISCEB Interdepartmental Research Center for Computational and Biotechnological Sciences, Second University of Naples, Naples, Italy
    PLoS ONE 4:e6226. 2009
    ..These PBPs are involved in the synthesis of peptidoglycans, essential mesh-like polymers that surround cellular enzymes and are crucial for the bacterium survival...
  6. doi request reprint A holistic approach to study the effects of natural antioxidants on inflammation and liver cancer
    Susan Costantini
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione Giovanni Pascale IRCCS Italia, via Ammiraglio Bianco, 83013, Mercogliano, Av, Italy
    Cancer Treat Res 159:311-23. 2014
    ....
  7. doi request reprint Common structural interactions between the receptors CXCR3, CXCR4 and CXCR7 complexed with their natural ligands, CXCL11 and CXCL12, by a modeling approach
    Susan Costantini
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione Giovanni Pascale, IRCCS, Italy Electronic address
    Cytokine 64:316-21. 2013
    ....
  8. doi request reprint Cancer biomarker profiling in patients with chronic hepatitis C virus, liver cirrhosis and hepatocellular carcinoma
    Susan Costantini
    National Cancer Institute G Pascale Foundation Oncology Research Center of Mercogliano CROM, Mercogliano, Italy
    Oncol Rep 29:2163-8. 2013
    ....
  9. pmc Genealogy of an ancient protein family: the Sirtuins, a family of disordered members
    Susan Costantini
    Pascale Foundation National Cancer Institute Cancer Research Center CROM, via Ammiraglio Bianco, 83013, Mercogliano, Italy
    BMC Evol Biol 13:60. 2013
    ..Aim of this work is to understand what structural properties are shared among members of this family in humans as well as in other organisms...
  10. doi request reprint Gene expression signature of human HepG2 cell line
    S Costantini
    INT Pascale, Cancer Research Centre of Mercogliano, Mercogliano, Italy
    Gene 518:335-45. 2013
    ....
  11. doi request reprint Evaluation of selenite effects on selenoproteins and cytokinome in human hepatoma cell lines
    Fabiola Rusolo
    Cancer Research Center, Pascale Foundation National Cancer Institute, Mercogliano AV 83013, Italy
    Molecules 18:2549-62. 2013
    ..Finally, interactomic studies show that GPX1 and SELK, and the four pro-inflammatory cytokines are functionally correlated evidencing a putative anti-inflammatory role for the selenite...
  12. pmc Cytokinome profile of patients with type 2 diabetes and/or chronic hepatitis C infection
    Susan Costantini
    INT G Pascale Oncology Research Centre of Mercogliano, Mercogliano, Italy
    PLoS ONE 7:e39486. 2012
    ....
  13. ncbi request reprint Has selenium a chemopreventive effect on hepatocellular carcinoma?
    S Costantini
    INT Pascale CROM, via Ammiraglio Bianco, Mercogliano AV, Italy
    Mini Rev Med Chem 11:599-610. 2011
    ....
  14. doi request reprint Serum cytokine levels as putative prognostic markers in the progression of chronic HCV hepatitis to cirrhosis
    Susan Costantini
    Centro Ricerche Oncologiche di Mercogliano Fiorentino Lo Vuolo, via Ammiraglio Bianco, Mercogliano AV, Italy
    Eur Cytokine Netw 21:251-6. 2010
    ..Finally, these data will be used to define a cytokinome profile, which might prove useful for studies involving the transition of chronic inflammation to neoplastic processes...
  15. ncbi request reprint Frequencies of specific peptides in intrinsic disordered protein domains
    Susan Costantini
    Centro Ricerche Oncologiche di Mercogliano Fiorentino Lo Vuolo, via Ammiraglio Bianco, 83013 Mercogliano AV Italy
    Protein Pept Lett 17:1398-402. 2010
    ..The best results were obtained using the tri-peptides, much more able to gain structural information from sequences compared to the di-peptides...
  16. doi request reprint The N-terminal region of CXCL11 as structural template for CXCR3 molecular recognition: synthesis, conformational analysis, and binding studies
    Pasquale Palladino
    Pascale Foundation National Cancer Institute, Naples, Italy
    Chem Biol Drug Des 80:254-65. 2012
    ....
  17. doi request reprint Modelling of the membrane receptor CXCR3 and its complexes with CXCL9, CXCL10 and CXCL11 chemokines: putative target for new drug design
    Tiziana Trotta
    Department of Biochemistry and Biophysics and Interdepartmental Research Center for Computational and Biotechnological Sciences, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Mol Immunol 47:332-9. 2009
    ..Finally, the interaction residues involved in the formation of the complexes have been highlighted and analyzed in order to be used for drug design...
  18. doi request reprint Structural and functional studies of the human selenium binding protein-1 and its involvement in hepatocellular carcinoma
    Raffaele Raucci
    INT CROM, Pascale Foundation National Cancer Institute Cancer Research Center, via Ammiraglio Bianco, 83013 Mercogliano, Italy
    Biochim Biophys Acta 1814:513-22. 2011
    ..Experimentally we found that only one cysteine is titratable by DTNB. This supports the hypothesis that Cys57 is a residue functionally important and this may open new pharmacological perspectives...
  19. doi request reprint Serum cytokine levels in patients with hepatocellular carcinoma
    Francesca Capone
    Centro Ricerche Oncologiche di Mercogliano CROM Fiorentino Lo Vuolo, Mercogliano, Italy
    Eur Cytokine Netw 21:99-104. 2010
    ..This could lead to better definition of the disease state, and to an increased understanding of the relationships between chronic inflammation and cancer...
  20. ncbi request reprint Dissimilar cytokine patterns in different human liver and colon cancer cell lines
    Eliana Guerriero
    Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale, IRCCS, Italy
    Cytokine 64:584-9. 2013
    ..Our aim was to identify what cytokines were significantly different correlating similarities and differences to the specific inflammation status of each cellular model of cancer. ..
  21. doi request reprint Structure-function relationship and evolutionary history of the human selenoprotein M (SelM) found over-expressed in hepatocellular carcinoma
    Stefano Guariniello
    Biochemistry, Biophysics and General Pathology Department and Computational Biology Doctorate, Second University of Naples, Naples, Italy
    Biochim Biophys Acta 1844:447-56. 2014
    ..Moreover, we modeled some of its mutants to obtain structural information helpful for structure-based drug design. ..
  22. doi request reprint Understanding the role of the topology in protein folding by computational inverse folding experiments
    Antonio Mucherino
    Department of Mathematics, Second University of Naples, Via Vivaldi 43, I 81100 Caserta, Italy
    Comput Biol Chem 32:233-9. 2008
    ..This agrees with the recent view that the backbone plays an important role in the protein folding process and that the amino acid sequence chooses its own fold within a limited total number of folds...
  23. doi request reprint The protein-protein interaction network of the human Sirtuin family
    Ankush Sharma
    Biochemistry, Biophysics and General Pathology Department, Second University of Naples, Naples, Italy
    Biochim Biophys Acta 1834:1998-2009. 2013
    ..Finally, we extracted from the Sirtuin sub-interactome subnets related to cancer, aging and post-translational modifications for information on key nodes and topological space of the subnets in the Sirt family network. ..
  24. doi request reprint Effects of lipoic acid, caffeic acid and a synthesized lipoyl-caffeic conjugate on human hepatoma cell lines
    Eliana Guerriero
    Pascale Foundation National Cancer Institute Cancer Research Center, Mercogliano AV, Italy
    Molecules 16:6365-77. 2011
    ..The obtained cytokine pattern showed that, at the increasing of three molecules concentrations, three pro-inflammatory cytokines such as IL-1β, IL-8 and TNF-α decreased whereas the anti-inflammatory cytokine such as IL-10 increased...
  25. ncbi request reprint Synergistic antitumor effect of Doxorubicin and tacrolimus (FK506) on hepatocellular carcinoma cell lines
    Francesca Capone
    Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale, IRCCS, 80131 Naples, Italy
    ScientificWorldJournal 2014:450390. 2014
    ..In conclusion, future studies could relate to the doxorubicin/tacrolimus combination effects in mice models bearing HCC in order to see if this formulation could be useful in HCC treatment. ..
  26. doi request reprint Peptides targeting chemokine receptor CXCR4: structural behavior and biological binding studies
    Susan Costantini
    Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale IRCCS, Naples, Italy
    J Pept Sci 20:270-8. 2014
    ..This affinity is not revealed for CXCR7, indicating a specificity for CXCR4...
  27. pmc Evaluation of the structural quality of modeled proteins by using globularity criteria
    Susan Costantini
    CRISCEB Research Center of Computational and Biotechnological Sciences, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    BMC Struct Biol 7:9. 2007
    ....
  28. doi request reprint Structural characterization and comparative modeling of PD-Ls 1-3, type 1 ribosome-inactivating proteins from summer leaves of Phytolacca dioica L
    Antimo Di Maro
    Dipartimento di Scienze della Vita, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, I 81100 Caserta, Italy
    Biochimie 91:352-63. 2009
    ..Despite an overall high structural similarity, the comparative modeling of PD-L1, PD-L2, PD-L3 and PD-L4 has shown potential influences of the glycidic chains on their adenine polynucleotide glycosylase activity on different substrates...
  29. doi request reprint Functional hypothesis on miraculin' sweetness by a molecular dynamics approach
    Antonella Paladino
    Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Biochem Biophys Res Commun 396:726-30. 2010
    ....
  30. pmc Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment
    Giuseppe Castello
    Oncology Research Centre of Mercogliano CROM, Mercogliano AV, Italy
    J Transl Med 8:109. 2010
    ..The present review focuses on: the role of inflammation in carcinogenesis, the clinical impact of HCC and the inadequacy of the actual therapy, the chemoprevention targeting the microenvironment...
  31. ncbi request reprint Characterization and kinetics studies of water buffalo (Bubalus bubalis) myoglobin
    Roberta Dosi
    Department of Life Sciences, Second University of Naples, Via Vivaldi 43, I 81100 Caserta, Italy
    Comp Biochem Physiol B Biochem Mol Biol 145:230-8. 2006
    ..393+/-0.005 g/100 g of tissue) and consequently MetMb, which are almost twice as high as bovine meat (Mb: 0.209+/-0.003 g/100 g of tissue)...