L E Adinolfi

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. doi request reprint Chronic HCV infection is a risk factor of ischemic stroke
    Luigi E Adinolfi
    Department of Medicine, Surgery, Neurology, Geriatric and Metabolic Diseases, Second University of Naples, Internal Medicine of Clinic Hospital of Marcianise, ASL Caserta, Italy Electronic address
    Atherosclerosis 231:22-6. 2013
  2. doi request reprint The predictive value of steatosis in hepatitis C virus infection
    Luigi E Adinolfi
    Department of Medicine, Surgery, Neurology, Geriatric and Metabolic Disease, Second University of Naples, Internal Medicine of Clinic Hospital of Marcianise, ASL Caserta, Italy
    Expert Rev Gastroenterol Hepatol 7:205-13. 2013
  3. doi request reprint Chronic HCV infection is a risk of atherosclerosis. Role of HCV and HCV-related steatosis
    Luigi E Adinolfi
    Internal Medicine and Hepatology, Second University of Naples, Italy
    Atherosclerosis 221:496-502. 2012
  4. doi request reprint Leukocyte interferon-alpha and ribavirin for treatment of chronic hepatitis C patients intolerant to pegylated-interferon
    Luigi E Adinolfi
    Internal Medicine and Hepatology, Facolta di Medicina e Chirurgia, Second University of Naples Medical School, Naples, Italy
    Intern Emerg Med 4:485-90. 2009
  5. ncbi request reprint Review article: hepatitis C virus-associated steatosis--pathogenic mechanisms and clinical implications
    L E Adinolfi
    Internal Medicine and Hepatology, Second University of Naples, Naples, Italy
    Aliment Pharmacol Ther 22:52-5. 2005
  6. ncbi request reprint Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients
    Luigi E Adinolfi
    Division of Internal Medicine and Hepatology, Second University of Naples, Faculty of Medicine, Naples, Italy
    Hepatology 41:995-1003. 2005
  7. pmc Effects of alpha interferon induction plus ribavirin with or without amantadine in the treatment of interferon non-responsive chronic hepatitis C: a randomised trial
    L E Adinolfi
    Division of Internal Medicine and Hepatology, Faculty of Medicine, Second University of Naples, Naples, Italy
    Gut 52:701-5. 2003
  8. ncbi request reprint Hepatic fibrosis plays a central role in the pathogenesis of thrombocytopenia in patients with chronic viral hepatitis
    L E Adinolfi
    Institute of Medical Therapy, Second University of Naples, Naples, Italy
    Br J Haematol 113:590-5. 2001
  9. ncbi request reprint Serum HCV RNA levels correlate with histological liver damage and concur with steatosis in progression of chronic hepatitis C
    L E Adinolfi
    Institute of Medical Therapy, Faculty of Medicine, Second University of Naples, Italy
    Dig Dis Sci 46:1677-83. 2001
  10. ncbi request reprint Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
    L E Adinolfi
    Internal Medicine and Hepatology, Second University of Naples, Naples, Italy
    Hepatology 33:1358-64. 2001

Collaborators

Detail Information

Publications25

  1. doi request reprint Chronic HCV infection is a risk factor of ischemic stroke
    Luigi E Adinolfi
    Department of Medicine, Surgery, Neurology, Geriatric and Metabolic Diseases, Second University of Naples, Internal Medicine of Clinic Hospital of Marcianise, ASL Caserta, Italy Electronic address
    Atherosclerosis 231:22-6. 2013
    ..Thus, we hypothesized that subjects carrying HCV are at higher risk of stroke. Accordingly, we evaluated prevalence and role of HCV infection in patients with stroke...
  2. doi request reprint The predictive value of steatosis in hepatitis C virus infection
    Luigi E Adinolfi
    Department of Medicine, Surgery, Neurology, Geriatric and Metabolic Disease, Second University of Naples, Internal Medicine of Clinic Hospital of Marcianise, ASL Caserta, Italy
    Expert Rev Gastroenterol Hepatol 7:205-13. 2013
    ..The authors summarize current knowledge of impact of steatosis on the above reported clinical conditions associated with HCV infection...
  3. doi request reprint Chronic HCV infection is a risk of atherosclerosis. Role of HCV and HCV-related steatosis
    Luigi E Adinolfi
    Internal Medicine and Hepatology, Second University of Naples, Italy
    Atherosclerosis 221:496-502. 2012
    ..We hypothesized that HCV per se and HCV-related steatosis could favour atherosclerosis. Thus, in CHC patients we assessed: (a) the prevalence of atherosclerosis; (b) the role of HCV, cardio-metabolic risk factors and hepatic histology...
  4. doi request reprint Leukocyte interferon-alpha and ribavirin for treatment of chronic hepatitis C patients intolerant to pegylated-interferon
    Luigi E Adinolfi
    Internal Medicine and Hepatology, Facolta di Medicina e Chirurgia, Second University of Naples Medical School, Naples, Italy
    Intern Emerg Med 4:485-90. 2009
    ..e., 24% for cirrhotics and 50% for CHC, and 25% for genotype 1 and 60% for genotypes 2/3. The data indicate that Le-IFN-alpha plus ribavirin is a useful and effective treatment for CHC patients who are intolerant to peg-IFNs...
  5. ncbi request reprint Review article: hepatitis C virus-associated steatosis--pathogenic mechanisms and clinical implications
    L E Adinolfi
    Internal Medicine and Hepatology, Second University of Naples, Naples, Italy
    Aliment Pharmacol Ther 22:52-5. 2005
    ..The role of hepatitis C virus (HCV)-related steatosis in these epidemiological associations remains to be determined...
  6. ncbi request reprint Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients
    Luigi E Adinolfi
    Division of Internal Medicine and Hepatology, Second University of Naples, Faculty of Medicine, Naples, Italy
    Hepatology 41:995-1003. 2005
    ....
  7. pmc Effects of alpha interferon induction plus ribavirin with or without amantadine in the treatment of interferon non-responsive chronic hepatitis C: a randomised trial
    L E Adinolfi
    Division of Internal Medicine and Hepatology, Faculty of Medicine, Second University of Naples, Naples, Italy
    Gut 52:701-5. 2003
    ..Fifty per cent of chronic hepatitis C patients are non-responders to interferon. At present, there are no recommended therapeutic options for non-responders...
  8. ncbi request reprint Hepatic fibrosis plays a central role in the pathogenesis of thrombocytopenia in patients with chronic viral hepatitis
    L E Adinolfi
    Institute of Medical Therapy, Second University of Naples, Naples, Italy
    Br J Haematol 113:590-5. 2001
    ..001). These data indicate that advanced hepatic fibrosis, causing an altered production of thrombopoietin and portal hypertension, plays the central role in the pathogenesis of thrombocytopenia in chronic viral hepatitis...
  9. ncbi request reprint Serum HCV RNA levels correlate with histological liver damage and concur with steatosis in progression of chronic hepatitis C
    L E Adinolfi
    Institute of Medical Therapy, Faculty of Medicine, Second University of Naples, Italy
    Dig Dis Sci 46:1677-83. 2001
    ..The data indicate that the liver damage is correlated with the HCV RNA levels and that a high viral load acts together with steatosis in accelerating the progression of liver injury...
  10. ncbi request reprint Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
    L E Adinolfi
    Internal Medicine and Hepatology, Second University of Naples, Naples, Italy
    Hepatology 33:1358-64. 2001
    ..05). Our data indicate that steatosis is an important cofactor in increasing liver necroinflammatory activity and in accelerating fibrosis in CHC. Visceral obesity and genotype 3a play a role in the development of steatosis...
  11. doi request reprint Steatosis is the predictor of relapse in HCV genotype 3- but not 2-infected patients treated with 12 weeks of pegylated interferon-α-2a plus ribavirin and RVR
    L Restivo
    Internal Medicine and Hepatology, Second University of Naples, Naples, Italy
    J Viral Hepat 19:346-52. 2012
    ..This is not the case for genotype 3. Steatosis is the independent predictor of relapse. New therapeutic strategies are necessary for this subgroup of HCV genotype 3...
  12. doi request reprint Microsomal triglyceride transfer protein (MTP) -493G/T gene polymorphism contributes to fat liver accumulation in HCV genotype 3 infected patients
    R Zampino
    Departments of Internal Medicine and Hepatology, F Cedrangolo, Second University of Naples, Naples, Italy
    J Viral Hepat 15:740-6. 2008
    ..In conclusion the presence of T allele of MTP-493G/T gene polymorphism predisposes patients infested with HCV genotype 3 to develop higher degree of fatty liver accumulation...
  13. ncbi request reprint Hepatic steatosis and insulin resistance are associated with serum imbalance of adiponectin/tumour necrosis factor-alpha in chronic hepatitis C patients
    E Durante-Mangoni
    Internal Medicine and Hepatology, Second University of Naples Medical School, Napoli, Italy
    Aliment Pharmacol Ther 24:1349-57. 2006
    ..Steatosis and insulin resistance (IR) have a pathogenic role in chronic hepatitis C (HCV). Adipocytokines balance modulates hepatic lipid content and IR...
  14. ncbi request reprint Dual or single hepatitis B and C virus infections in childhood cancer survivors: long-term follow-up and effect of interferon treatment
    R Utili
    Institute of Medical Therapy, Chair of Infectious Diseases, Pediatric Oncologic Service, 2nd University of Naples, Medical School, Naples, Italy
    Blood 94:4046-52. 1999
    ..A reciprocal interference on viral replication between HBV and HCV may occur in coinfected patients. Treatment seems to be effective for selected cases and is justified in view of the uncertain prognosis of the disease in these patients...
  15. ncbi request reprint Streptococcus bovis endocarditis and its association with chronic liver disease: an underestimated risk factor
    M F Tripodi
    Department of Internal Medicine, Second University of Naples, I 80135 Naples, Italy
    Clin Infect Dis 38:1394-400. 2004
    ..The in-hospital mortality rate (16.7%) was correlated with delayed diagnosis and advanced liver diseases. In our city, S. bovis I endocarditis is frequently correlated with liver diseases; diskitis may be the first sign of the disease...
  16. ncbi request reprint Treatment of pulmonary nocardiosis in heart-transplant patients: importance of susceptibility studies
    M F Tripodi
    Institute of Medical Therapy, Second University of Naples, Via D Cotugno 1, 80135 Naples, Italy
    Clin Transplant 15:415-20. 2001
    ....
  17. doi request reprint Abdominal fat interacts with PNPLA3 I148M, but not with the APOC3 variant in the pathogenesis of liver steatosis in chronic hepatitis C
    R Zampino
    Internal Medicine and Hepatology, Second University of Naples, Naples, Italy
    J Viral Hepat 20:517-23. 2013
    ..APOC3 polymorphisms had no effect on the development of steatosis and no influence on the PNPLA3 polymorphism. The amount of abdominal fat can increase the association of PNPLA3 p.I148M with liver steatosis...
  18. ncbi request reprint Intracellular activity of cefamandole and aztreonam against phagocytosed Escherichia coli and Staphylococcus aureus
    L E Adinolfi
    Institute of Medical Therapy, University of Naples, 1st Medical School, Italy
    J Antimicrob Chemother 24:927-35. 1989
    ..coli that seems at least in part due to a positive cooperation of antibiotics with the O2-independent microbicidal system of macrophages...
  19. ncbi request reprint Clinical efficacy of dirithromycin versus miocamycin in tonsillopharyngitis
    G Ruggiero
    Institute of Medical Therapy, 1st Medical School, University of Naples, Italy
    J Antimicrob Chemother 31:103-9. 1993
    ..The results of this study suggest that dirithromycin has comparable safety and efficacy to miocamycin in the treatment of streptococcal pharyngitis/tonsillitis infections caused by Group A streptococci...
  20. ncbi request reprint Reversible sudden hearing loss in a chronic hepatitis C patient who achieved a sustained response to antiviral re-treatment
    Rosa Zampino
    Department Internal Medicine and Hepatology, Second University of Naples, Naples, Italy
    Infez Med 20:117-9. 2012
    ..He developed a reversible hearing loss during the first course of PEG-IFN + ribavirin, but achieved sustained viral clearance and biochemical normalization after PEG-IFN + ribavirin re-treatment...
  21. ncbi request reprint Clinical reactivation during lamivudine treatment correlates with mutations in the precore/core promoter and polymerase regions of hepatitis B virus in patients with anti-hepatitis B e-positive chronic hepatitis
    A Marrone
    Internal Medicine and Hepatology, Second University of Naples, Napoli, Italy
    Aliment Pharmacol Ther 22:707-14. 2005
    ..Drug-resistant mutants may emerge in patients with chronic hepatitis B receiving lamivudine therapy...
  22. ncbi request reprint Estradiol-17 beta-D-glucuronide (E-17G) cholestasis in perfused rat liver: fate of E-17G and choleretic responses to bile salts
    R Utili
    Institute of Medical Therapy, First Medical School, Naples, Italy
    Hepatology 11:735-42. 1990
    ..abstract truncated at 250 words)..
  23. ncbi request reprint First definite case of aortic valve endocarditis due to Moraxella phenylpyruvica
    M F Tripodi
    Institute of Medical Therapy, Faculty of Medicine, Second University of Naples, Via D Cotugno 1 c o Ospedale Gesù e Maria, 80135 Naples, Italy
    Eur J Clin Microbiol Infect Dis 21:480-2. 2002
    ..The diagnosis was delayed because of the confounding positivity of the Widal and Wright tests. The patient was cured with surgical valve replacement and antibiotic treatment...
  24. ncbi request reprint Clinically-irrelevant positivity for serum proteinase 3-ANCA in HIV disease
    C Romano
    Division of Internal Medicine, Allergy and Clinical Immunology, Polyclinic Hospital of the Second University of Naples, Naples, Italy, and Department of Medical and Surgical Sciences, Second University of Naples, Naples, Italy
    Int J Immunopathol Pharmacol 26:957-9. 2013
    ....
  25. ncbi request reprint Hepatitis C and steatosis: a reappraisal
    A Lonardo
    Unità Operativa di Medicina Interna e Gastroenterologia, Nuovo Ospedale Civile Estense di Baggiovara, Modena, Italy
    J Viral Hepat 13:73-80. 2006
    ..These observations indicate the need to evaluate the efficacy of combined antiviral and 'metabolic' approaches vs standard antiviral regimes in patients with steatosis and HCV chronic infection...