Nicola Scichilone

Summary

Country: Italy

Publications

  1. pmc Patient perspectives in the management of asthma: improving patient outcomes through critical selection of treatment options
    Nicola Scichilone
    Dipartimento di Medicina, Pneumologia, Fisiologia e Nutrizione Umana DIMPEFINU, University of Palermo, Palermo, Italy
    Patient Prefer Adherence 4:17-23. 2010
  2. pmc Anti-inflammatory effects of pre-seasonal Th1-adjuvant vaccine to Parietaria judaica in asthmatics
    Nicola Scichilone
    Dipartimento Biomedico di Medicina, Interna e Specialistica Di Bi M I S, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    J Asthma Allergy 4:19-25. 2011
  3. pmc A 15-year-old boy with anterior chest pain, progressive dyspnea, and subcutaneous emphysema of the neck
    Nicola Scichilone
    Dipartimento di Medicina, Pneumologia, Fisiologia e Nutrizione Umana DIMPEFINU, Sezione di Pneumologia e Medicina, University of Palermo, 90146 Palermo, Italy
    J Allergy (Cairo) 2009:496890. 2009
  4. pmc BMI can influence adult males' and females' airway hyperresponsiveness differently
    Bruno Sposato
    Unit of Pneumology, Misericordia Hospital, Via Senese 161, 58100, Grosseto, Italy
    Multidiscip Respir Med 7:45. 2012
  5. ncbi request reprint Airway hyperresponsiveness in the elderly: prevalence and clinical implications
    N Scichilone
    Institute of Respiratory Diseases, University of Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Eur Respir J 25:364-75. 2005
  6. pmc Association between reduced bronchodilatory effect of deep inspiration and loss of alveolar attachments
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, Universita di Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Respir Res 6:55. 2005
  7. doi request reprint Effects of extra-fine inhaled beclomethasone/formoterol on both large and small airways in asthma
    N Scichilone
    Department of Medicine, Pneumology, Physiology and Human Nutrition DIMPEFINU, University of Palermo, Palermo, Italy
    Allergy 65:897-902. 2010
  8. ncbi request reprint Reduced airway responsiveness in nonelite runners
    Nicola Scichilone
    Institute of Medicine and Pneumology, Respiratory Unit University of Palermo, Italy
    Med Sci Sports Exerc 37:2019-25. 2005
  9. ncbi request reprint Deep inspiration-induced changes in lung volume decrease with severity of asthma
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, Universita di Palermo, 90146 Palermo, Italy
    Respir Med 101:951-6. 2007
  10. doi request reprint Should atopy be assessed in elderly patients with respiratory symptoms suggestive of asthma?
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    Expert Rev Respir Med 4:585-91. 2010

Detail Information

Publications50

  1. pmc Patient perspectives in the management of asthma: improving patient outcomes through critical selection of treatment options
    Nicola Scichilone
    Dipartimento di Medicina, Pneumologia, Fisiologia e Nutrizione Umana DIMPEFINU, University of Palermo, Palermo, Italy
    Patient Prefer Adherence 4:17-23. 2010
    ..The success of any anti-asthmatic treatment depends on the choice of the correct device and the adherence to therapy...
  2. pmc Anti-inflammatory effects of pre-seasonal Th1-adjuvant vaccine to Parietaria judaica in asthmatics
    Nicola Scichilone
    Dipartimento Biomedico di Medicina, Interna e Specialistica Di Bi M I S, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    J Asthma Allergy 4:19-25. 2011
    ..The ultra-short course pre-seasonal allergy vaccine, containing appropriate allergoids with the adjuvant monophosphoryl lipid A (MPL), may be effective in treating allergic symptoms...
  3. pmc A 15-year-old boy with anterior chest pain, progressive dyspnea, and subcutaneous emphysema of the neck
    Nicola Scichilone
    Dipartimento di Medicina, Pneumologia, Fisiologia e Nutrizione Umana DIMPEFINU, Sezione di Pneumologia e Medicina, University of Palermo, 90146 Palermo, Italy
    J Allergy (Cairo) 2009:496890. 2009
    ..We suggest that the diagnosis of asthma should be considered in the differential diagnosis of pneumomediastinum in adolescence...
  4. pmc BMI can influence adult males' and females' airway hyperresponsiveness differently
    Bruno Sposato
    Unit of Pneumology, Misericordia Hospital, Via Senese 161, 58100, Grosseto, Italy
    Multidiscip Respir Med 7:45. 2012
    ..abstract:..
  5. ncbi request reprint Airway hyperresponsiveness in the elderly: prevalence and clinical implications
    N Scichilone
    Institute of Respiratory Diseases, University of Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Eur Respir J 25:364-75. 2005
    ..Assessment of airway hyperresponsiveness in the aged should be considered as an additional tool in the diagnostic work-up in the subset of elderly subjects with long-term smoking exposure and/or documented atopy...
  6. pmc Association between reduced bronchodilatory effect of deep inspiration and loss of alveolar attachments
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, Universita di Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Respir Res 6:55. 2005
    ..This study was designed to investigate whether the impairment in this effect is associated with loss of alveolar attachments...
  7. doi request reprint Effects of extra-fine inhaled beclomethasone/formoterol on both large and small airways in asthma
    N Scichilone
    Department of Medicine, Pneumology, Physiology and Human Nutrition DIMPEFINU, University of Palermo, Palermo, Italy
    Allergy 65:897-902. 2010
    ..Aim: To evaluate whether treatment with an extra-fine inhaled combination provides additional effects vs a nonextra-fine combination on airway function...
  8. ncbi request reprint Reduced airway responsiveness in nonelite runners
    Nicola Scichilone
    Institute of Medicine and Pneumology, Respiratory Unit University of Palermo, Italy
    Med Sci Sports Exerc 37:2019-25. 2005
    ....
  9. ncbi request reprint Deep inspiration-induced changes in lung volume decrease with severity of asthma
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, Universita di Palermo, 90146 Palermo, Italy
    Respir Med 101:951-6. 2007
    ..01) and to weekly salbutamol usage (r=-0.47, P=0.004). These observations provide support to the hypothesis that the attenuation of the bronchodilatory effect of DI contributes to the severity of the clinical manifestations of asthma...
  10. doi request reprint Should atopy be assessed in elderly patients with respiratory symptoms suggestive of asthma?
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    Expert Rev Respir Med 4:585-91. 2010
    ..For this reason, the evaluation of the atopic condition in the geriatric patient is recommended. The role of atopy as regards diagnosis, therapy and prognosis of asthma in the elderly is addressed...
  11. ncbi request reprint The mini nutritional assessment is associated with the perception of dyspnoea in older subjects with advanced COPD
    Nicola Scichilone
    DIMPEFINU, Universita di Palermo, Via Trabucco 180, 90146, Palermo, Italy
    Age Ageing 37:214-7. 2008
  12. pmc Clinical implications of airway hyperresponsiveness in COPD
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, Universita di Palermo, Palermo, Italy
    Int J Chron Obstruct Pulmon Dis 1:49-60. 2006
    ..Smoking cessation has been shown to reduce AHR. Further studies are needed to elucidate whether this functional change is associated with improvement in lung function and respiratory symptoms...
  13. ncbi request reprint The bronchodilatory effect of deep inspiration diminishes with aging
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, Universita di Palermo, Via Trabucco 180, Palermo 90146, Italy
    Respir Med 98:838-43. 2004
    ..0001) and age (P=0.02) entered the model. Our data raise the hypothesis that aging is associated with reduction in DI-induced bronchodilation...
  14. doi request reprint Effects of exercise training on airway responsiveness and airway cells in healthy subjects
    Nicola Scichilone
    Dept of Internal Medicine, Div of Pulmonology DIBIMIS Univ of Palermo, Villa Sofia Cervello Hospital, Via Trabucco 180, 90146 Palermo, Italy
    J Appl Physiol (1985) 109:288-94. 2010
    ....
  15. doi request reprint The impact of age on prevalence of positive skin prick tests and specific IgE tests
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica DIBIMIS, Sezione di Pneumologia, University of Palermo, Villa Sofia Cervello Hospital, Palermo, Italy
    Respir Med 105:651-8. 2011
    ....
  16. pmc The airway response to deep inspirations decreases with COPD severity and is associated with airway distensibility assessed by computed tomography
    Nicola Scichilone
    Dipartimento di Medicina, Pneumologia, Fisiologia e Nutrizione Umana, Univ of Palermo, 90146 Palermo, Italy
    J Appl Physiol (1985) 105:832-8. 2008
    ....
  17. doi request reprint The effect of intranasal corticosteroids on asthma control and quality of life in allergic rhinitis with mild asthma
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Villa Sofia Cervello Hospital, Palermo, Italy
    J Asthma 48:41-7. 2011
    ..We explored whether the effect of nasal treatment on asthma control and respiratory-related quality of life (HRQoL) is mediated by inflammatory changes of the upper and lower airways...
  18. ncbi request reprint Bronchodilatory effect of deep inspiration is absent in subjects with mild COPD
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, University of Palermo, Palermo, Italy
    Chest 125:2029-35. 2004
    ..To investigate whether the bronchodilatory effect of deep inspiration is impaired in subjects with COPD...
  19. ncbi request reprint Monitoring response to treatment in asthma management: food for thought
    N Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, University of Palermo, Palermo, Italy
    Clin Exp Allergy 34:1168-77. 2004
    ..A careful review of the available techniques, and the evaluation of their sensitivity and specificity in the clinical setting is warranted...
  20. doi request reprint Alterations of the beneficial effect of deep inspiration in scleroderma: relationships between lung function and imaging
    Nicola Scichilone
    Dipartimento di Medicina, Pneumologia, Fisiologia e Nutrizione Umana, Palermo, Italy
    Respiration 76:303-10. 2008
    ..It has been postulated that the beneficial effects of deep inspiration are dependent on the magnitude of airway distension by virtue of airway to parenchyma interdependence...
  21. pmc Is health-related quality of life associated with upper and lower airway inflammation in asthmatics?
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica DIBIMIS, Sezione di Pneumologia, University of Palermo, 90146 Palermo, Italy
    Biomed Res Int 2013:539290. 2013
    ..However, the relationship between airway inflammation and HR-QoL in patients with asthma and rhinitis has not been fully investigated. We explored whether the inflammation of upper and lower airways is associated with HR-QoL...
  22. ncbi request reprint Effects of exercise training on airway closure in asthmatics
    Nicola Scichilone
    Department of Internal Medicine, Section of Pulmonology, DIBIMIS University of Palermo, Palermo, Italy
    J Appl Physiol (1985) 113:714-8. 2012
    ..28). This study indicates that a short course of physical training is capable of reducing airway responsiveness in mild asthmatics...
  23. doi request reprint Prognostic value of FEV1/FEV6 in elderly people
    Claudio Sorino
    Department of Medicine, Pneumology, Physiology and Human Nutrition, University of Palermo, Via Trabucco 180, Palermo, Italy
    Clin Physiol Funct Imaging 31:101-7. 2011
    ..We evaluated whether FEV1/FEV6 is a significant predictor of mortality in elderly subjects and compared its prognostic value with that of FEV1/FVC and FEV1...
  24. doi request reprint Airway distensibility by HRCT in asthmatics and COPD with comparable airway obstruction
    Alida Benfante
    1Dipartimento di Biomedicina e Medicina Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    COPD 10:560-6. 2013
    ..Decreased airway distensibility (AD) in response to deep inspirations, as assessed by HRCT, has been associated with the severity of asthma and COPD...
  25. ncbi request reprint Sleep disorders in the elderly with and without chronic airflow obstruction: the SARA study
    Vincenzo Bellia
    Istituto di Medicina Generale e Pneumologia, University of Palermo, Italy
    Sleep 26:318-23. 2003
    ....
  26. pmc Diagnosis of airway obstruction in the elderly: contribution of the SARA study
    Claudio Sorino
    Biomedical Department of Internal and Specialist Medicine, Section of Pulmonology, University of Palermo, Italy
    Int J Chron Obstruct Pulmon Dis 7:389-95. 2012
    ..70 as the criterion for confirming airway obstruction is an open issue. In this study, we compared the criteria of lower limit of normal and fixed FEV(1)/FVC for diagnosis of airway obstruction, with a focus on healthy elderly people...
  27. ncbi request reprint Spirometry reference values for women and men aged 65-85 living in southern Europe: the effect of health outcomes
    Riccardo Pistelli
    Istituto di Medicina Generale e Pneumologia, University of Palermo, Palermo, Italy
    Respiration 70:484-9. 2003
    ..Spirometry is more and more frequently used for the diagnosis of respiratory diseases in the elderly people. Unfortunately, reliable predictive values for the spirometric variables in the elderly are lacking...
  28. doi request reprint Effects of exercise training and montelukast in children with mild asthma
    Maria R Bonsignore
    Department of Medicine, Pneumology, Physiology and Nutrition, University of Palermo, Italy
    Med Sci Sports Exerc 40:405-12. 2008
    ....
  29. ncbi request reprint Aging and disability affect misdiagnosis of COPD in elderly asthmatics: the SARA study
    Vincenzo Bellia
    Istituto di Medicina Generale e Pneumologia, University of Palermo, Italy
    Chest 123:1066-72. 2003
    ..This study investigated to what extent a diagnosis of COPD is erroneously made or the disease remains unrecognized in elderly asthmatic patients, and identified factors leading to misdiagnosis and underdiagnosis of asthma in such patients...
  30. pmc Safety and efficacy of montelukast as adjunctive therapy for treatment of asthma in elderly patients
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy
    Clin Interv Aging 8:1329-37. 2013
    ....
  31. doi request reprint Clinical and anti-inflammatory effects of ultra-short preseasonal vaccine to Parietaria in asthma
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica Di Bi M I S, Sezione di Pneumologia, University of Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Ther Adv Respir Dis 7:207-15. 2013
    ..We aimed at evaluating whether the ultra-short preseasonal course of immunotherapy contributes to asthma control...
  32. doi request reprint Alveolar nitric oxide and asthma control in mild untreated asthma
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    J Allergy Clin Immunol 131:1513-7. 2013
    ..We postulated that the inflammatory changes of the small airways are implicated in the lack of asthma control in mild asthma...
  33. doi request reprint Exhaled nitric oxide is associated with cyclic changes in sexual hormones
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica Di Bi M I S, Sezione di Pneumologia, University of Palermo, Via Trabucco 180, 90146 Palermo, Italy Electronic address
    Pulm Pharmacol Ther 26:644-8. 2013
    ..We hypothesized that changes in the levels of sexual hormones during the menstrual cycle influence the concentration of nitric oxide in the exhaled air (FeNO) and alveolar exhaled nitric oxide (CANO)...
  34. ncbi request reprint Assessing and accessing the small airways; implications for asthma management
    Nicola Scichilone
    Biomedical Department of Internal and Specialist Medicine DIBIMIS, Section of Pneumology, University of Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Pulm Pharmacol Ther 26:172-9. 2013
    ..Formulation advancements have made for easier treatment access to the smaller airways, with the new extrafine formulations resulting in better asthma control compared with non-extrafine formulations...
  35. ncbi request reprint Diagnosis and management of asthma in the elderly
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica Di Bi MIS, University of Palermo, Palermo, Italy Electronic address
    Eur J Intern Med 25:336-42. 2014
    ..The article addresses the main issues related to the diagnosis and treatment of asthma in the geriatric age. ..
  36. pmc Lung penetration and patient adherence considerations in the management of asthma: role of extra-fine formulations
    Nicola Scichilone
    Dipartimento di Biomedicina e Medicina Interna e Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    J Asthma Allergy 6:11-21. 2013
    ....
  37. ncbi request reprint The role of small airways in monitoring the response to asthma treatment: what is beyond FEV1?
    N Scichilone
    Dipartimento di Medicina, Umana DIMPEFINU, Sezione di Pneumologia e Medicina, University of Palermo, Palermo, Italy
    Allergy 64:1563-9. 2009
    ..In this study, extrafine formulations deliver inhaled drugs throughout the bronchial tree (both large and small airways) and are effective on parameters that directly or indirectly measure air trapping/airway closure...
  38. doi request reprint HRCT and scleroderma: semiquantitative evaluation of lung damage and functional abnormalities
    M Bellia
    Dipartimento di Biotecnologie e Medicina Legale, Sezione di Scienze Radiologiche, Universita di Palermo, Palermo, Italy
    Radiol Med 114:190-203. 2009
    ..In addition, we propose the use of high resolution computed tomography (HRCT) indices of alveolitis and fibrosis to discriminate between different stages of the disease...
  39. ncbi request reprint Prevalence of nocturnal asthma in a general population sample: determinants and effect of aging
    V Bellia
    Istituto di Pneumologia, University of Palermo, Italy
    J Asthma 37:595-602. 2000
    ..35-4.97). In conclusion, although the prevalence of NA was previously overestimated, our results indicate its importance, particularly among elderly patients who are exposed to a prominent risk of underdiagnosis and undertreatment...
  40. ncbi request reprint Airway remodelling assessed by sputum and high-resolution computed tomography in asthma and COPD
    A M Vignola
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie Respiratorie, Universita di Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Eur Respir J 24:910-7. 2004
    ....
  41. ncbi request reprint Effect of age and asthma duration upon elastase and alpha1-antitrypsin levels in adult asthmatics
    A M Vignola
    Istituto di Medicina Generale e Pneumologia, Universita di Palermo, Via Trabucco, Palermo, Italy
    Eur Respir J 22:795-801. 2003
    ....
  42. doi request reprint What proportion of chronic obstructive pulmonary disease outpatients is eligible for inclusion in randomized clinical trials?
    Nicola Scichilone
    Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy
    Respiration 87:11-7. 2014
    ..We aimed to explore to what extent an unselected population of chronic obstructive pulmonary disease (COPD) outpatients would be eligible for inclusion in randomized clinical trials (RCTs)...
  43. ncbi request reprint Aging and asthma: pathophysiological mechanisms
    A M Vignola
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie Respiratorie, Universita di Palermo, Italy
    Allergy 58:165-75. 2003
  44. ncbi request reprint Questionnaires, spirometry and PEF monitoring in epidemiological studies on elderly respiratory patients
    V Bellia
    Institute of Respiratory Diseases, University of Palermo, Palermo, Italy
    Eur Respir J Suppl 40:21s-27s. 2003
    ..Despite these methodological problems, peak expiratory flow monitoring has been successfully used in the evaluation of the effects of air pollution in normal and asthmatic subjects, and in the elderly...
  45. ncbi request reprint Increased airway inflammatory cells in endurance athletes: what do they mean?
    M R Bonsignore
    Institute of Medicine and Pneumology, University of Palermo, Palermo, Italy
    Clin Exp Allergy 33:14-21. 2003
    ..Inflammatory cells are increased in the airways of endurance athletes, but their role in causing exercise-induced respiratory symptoms and bronchoconstriction, or their possible long-term consequences, are uncertain...
  46. ncbi request reprint Validation of FEV6 in the elderly: correlates of performance and repeatability
    V Bellia
    Universitè di Palermo, DIMPEFINU, Via Trabucco 180, 90146 Palermo, Italy
    Thorax 63:60-6. 2008
    ..A study was undertaken to estimate FEV6 repeatability, to identify correlates of a good quality FEV6 measurement and of volumetric differences between FEV6 and FVC in elderly patients...
  47. ncbi request reprint Effects of chronic airway disease on health status of geriatric patients
    Raffaele Antonelli Incalzi
    Istituto di Medicina Interna e Geriatria, Catholic University, Roma, Italy
    Aging Clin Exp Res 16:26-33. 2004
    ....
  48. ncbi request reprint Inspiration through the nose increases the bronchoprotective effect of lung inflation
    Nicola Scichilone
    J Allergy Clin Immunol 119:501-3. 2007
  49. pmc Inhaled corticosteroids and the beneficial effect of deep inspiration in asthma
    Nicola Scichilone
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 172:693-9. 2005
    ..After steroid treatment, the beneficial effects of deep inspiration become significant determinants of the magnitude of airway hyperresponsiveness...
  50. ncbi request reprint The role of lung inflation in airway hyperresponsiveness and in asthma
    Nicola Scichilone
    Divisions of Allergy and Clinical Immunology and Respiratory and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Curr Allergy Asthma Rep 4:166-74. 2004
    ..This information could open new horizons in asthma therapy and prevention...