C Scarpignato

Summary

Country: Italy

Publications

  1. ncbi request reprint Towards the ideal regimen for Helicobacter pylori eradication: the search continues
    C Scarpignato
    Laboratory of Clinical Pharmacology, School of Medicine and Dentistry, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Dig Liver Dis 36:243-7. 2004
  2. ncbi request reprint Rifaximin, a poorly absorbed antibiotic: pharmacology and clinical potential
    Carmelo Scarpignato
    Laboratory of Clinical Pharmacology, Department of Human Anatomy, Pharmacology and Forensic Sciences, School of Medicine and Dentistry, University of Parma, Parma, Italy
    Chemotherapy 51:36-66. 2005
  3. ncbi request reprint Experimental and clinical pharmacology of rifaximin, a gastrointestinal selective antibiotic
    Carmelo Scarpignato
    Laboratory of Clinical Pharmacology, Department of Human Anatomy, Pharmacology and Forensic Sciences, School of Medicine and Dentistry, University of Parma, Parma, Italy
    Digestion 73:13-27. 2006
  4. ncbi request reprint Early esophageal transit study after laparoscopic fundoplication: how useful is it?
    Sandro Contini
    Department of General Surgery and Organ Transplantation, School of Medicine and Dentistry, University of Parma, Maggiore University Hospital, Via Gramsci 14, 43100, Parma, Italy
    Am J Surg 183:226-31. 2002
  5. pmc Piroxicam-β-cyclodextrin: a GI safer piroxicam
    C Scarpignato
    Clinical Pharmacology and Digestive Pathophysiology Unit, Department of Clinical and Experimental Medicine, University of Parma, Italy
    Curr Med Chem 20:2415-37. 2013
  6. doi request reprint Poor effectiveness of proton pump inhibitors in non-erosive reflux disease: the truth in the end!
    Carmelo Scarpignato
    Laboratory of Clinical Pharmacology, Division of Gastroenterology, Department of Clinical Sciences, University of Parma, Parma, Italy
    Neurogastroenterol Motil 24:697-704. 2012
  7. ncbi request reprint Acid suppression therapy: where do we go from here?
    Carmelo Scarpignato
    Laboratory of Clinical Pharmacology, Department of Anatomy, Pharmacology and Forensic Sciences, School of Medicine and Dentistry, University of Parma, Parma, Italy
    Dig Dis 24:11-46. 2006
  8. ncbi request reprint Antisecretory drugs, Helicobacter pylori infection and symptom relief in GORD: still an unexplored triangle
    C Scarpignato
    Laboratory of Clinical Pharmacology, School of Medicine and Dentistry, University of Parma, Italy
    Dig Liver Dis 37:468-74. 2005
  9. ncbi request reprint Review article: the opportunities and benefits of extended acid suppression
    C Scarpignato
    Laboratory of Clinical Pharmacology, Department of Anatomy, Pharmacology and Forensic Sciences, School of Medicine and Dentistry, University of Parma, Parma, Italy
    Aliment Pharmacol Ther 23:23-34. 2006
  10. ncbi request reprint NSAID-induced intestinal damage: are luminal bacteria the therapeutic target?
    C Scarpignato
    Laboratory of Clinical Pharmacology, School of Medicine and Dentistry, University of Parma, Via Volturno, 39 43100 Parma, Italy
    Gut 57:145-8. 2008

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Towards the ideal regimen for Helicobacter pylori eradication: the search continues
    C Scarpignato
    Laboratory of Clinical Pharmacology, School of Medicine and Dentistry, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Dig Liver Dis 36:243-7. 2004
  2. ncbi request reprint Rifaximin, a poorly absorbed antibiotic: pharmacology and clinical potential
    Carmelo Scarpignato
    Laboratory of Clinical Pharmacology, Department of Human Anatomy, Pharmacology and Forensic Sciences, School of Medicine and Dentistry, University of Parma, Parma, Italy
    Chemotherapy 51:36-66. 2005
    ..Besides widening the clinical use, the research on rifaximin is also focused on the synthesis of new derivatives and on the development of original formulations designed to expand the spectrum of its clinical use...
  3. ncbi request reprint Experimental and clinical pharmacology of rifaximin, a gastrointestinal selective antibiotic
    Carmelo Scarpignato
    Laboratory of Clinical Pharmacology, Department of Human Anatomy, Pharmacology and Forensic Sciences, School of Medicine and Dentistry, University of Parma, Parma, Italy
    Digestion 73:13-27. 2006
    ....
  4. ncbi request reprint Early esophageal transit study after laparoscopic fundoplication: how useful is it?
    Sandro Contini
    Department of General Surgery and Organ Transplantation, School of Medicine and Dentistry, University of Parma, Maggiore University Hospital, Via Gramsci 14, 43100, Parma, Italy
    Am J Surg 183:226-31. 2002
    ..Early complications of laparoscopic fundoplication, if immediately recognized, may be promptly treated laparoscopically with minimal morbidity. A suggested strategy for identification is a routine postoperative esophageal transit study...
  5. pmc Piroxicam-β-cyclodextrin: a GI safer piroxicam
    C Scarpignato
    Clinical Pharmacology and Digestive Pathophysiology Unit, Department of Clinical and Experimental Medicine, University of Parma, Italy
    Curr Med Chem 20:2415-37. 2013
    ..As a consequence, it should be considered as a useful addition to our therapeutic armamentarium...
  6. doi request reprint Poor effectiveness of proton pump inhibitors in non-erosive reflux disease: the truth in the end!
    Carmelo Scarpignato
    Laboratory of Clinical Pharmacology, Division of Gastroenterology, Department of Clinical Sciences, University of Parma, Parma, Italy
    Neurogastroenterol Motil 24:697-704. 2012
    ..A better and more predictable form of acid suppression should therefore be pursued...
  7. ncbi request reprint Acid suppression therapy: where do we go from here?
    Carmelo Scarpignato
    Laboratory of Clinical Pharmacology, Department of Anatomy, Pharmacology and Forensic Sciences, School of Medicine and Dentistry, University of Parma, Parma, Italy
    Dig Dis 24:11-46. 2006
    ....
  8. ncbi request reprint Antisecretory drugs, Helicobacter pylori infection and symptom relief in GORD: still an unexplored triangle
    C Scarpignato
    Laboratory of Clinical Pharmacology, School of Medicine and Dentistry, University of Parma, Italy
    Dig Liver Dis 37:468-74. 2005
  9. ncbi request reprint Review article: the opportunities and benefits of extended acid suppression
    C Scarpignato
    Laboratory of Clinical Pharmacology, Department of Anatomy, Pharmacology and Forensic Sciences, School of Medicine and Dentistry, University of Parma, Parma, Italy
    Aliment Pharmacol Ther 23:23-34. 2006
    ..Tenatoprazole appears to be a promising proton pump inhibitor for the treatment of acid-related diseases, where it has the potential to address unmet clinical needs...
  10. ncbi request reprint NSAID-induced intestinal damage: are luminal bacteria the therapeutic target?
    C Scarpignato
    Laboratory of Clinical Pharmacology, School of Medicine and Dentistry, University of Parma, Via Volturno, 39 43100 Parma, Italy
    Gut 57:145-8. 2008
  11. doi request reprint Proton pump inhibitors: the beginning of the end or the end of the beginning?
    Carmelo Scarpignato
    Laboratory of Clinical Pharmacology, Department of Anatomy, Pharmacology and Forensic Sciences, School of Medicine and Dentistry, University of Parma, Parma, Italy
    Curr Opin Pharmacol 8:677-84. 2008
    ..Since an increasing proportion of patients fail to respond to the best PPI treatment, more potent and long-acting drugs and more effective regimens are needed...
  12. doi request reprint Nonsteroidal antiinflammatory drug-related injury to the gastrointestinal tract: clinical picture, pathogenesis, and prevention
    Carmelo Scarpignato
    Division of Gastroenterology, Department of Clinical Sciences, University of Parma, Italy
    Gastroenterol Clin North Am 39:433-64. 2010
    ..The challenge is to develop safer NSAIDs by shifting from a focus on GI toxicity to the increasingly more appreciated cardiovascular toxicity...
  13. ncbi request reprint Somatostatin analogs for cancer treatment and diagnosis: an overview
    C Scarpignato
    Department of Internal Medicine, School of Medicine and Dentistry, University of Parma, Italy
    Chemotherapy 47:1-29. 2001
    ..g. transferring the SSTR-2 gene into neoplastic cells), which have been successfully tested in experimental studies, should be applied to human beings in a not too distant future...
  14. ncbi request reprint Somatostatin for upper gastrointestinal hemorrhage and pancreatic surgery. A review of its pharmacology and safety
    C Scarpignato
    Department of Internal Medicine, School of Medicine and Dentistry, University of Parma, Italy
    Digestion 60:1-16. 1999
    ..While the native peptide is the drug of choice in the acute hospital setting, the synthetic derivatives are better indicated, on outpatient basis, for the long-term management of chronic conditions...
  15. ncbi request reprint Prevention and treatment of non-steroidal anti-inflammatory drug-induced gastro-duodenal damage: rationale for the use of antisecretory compounds
    C Scarpignato
    Department of Internal Medicine, School of Medicine and Dentistry, University of Parma, Italy
    Ital J Gastroenterol Hepatol 31:S63-72. 1999
    ..Further studies are, therefore, needed to better elucidate the respective role of the various pharmacological actions in their mucosal protective activity as well as to assess the clinical relevance of each of them...
  16. ncbi request reprint Management of irritable bowel syndrome: novel approaches to the pharmacology of gut motility
    C Scarpignato
    Department of Gastroenterology and Hepatology, Faculty of Medicine, University of Nantes, France
    Can J Gastroenterol 13:50A-65A. 1999
    ..Finally, when administered in small pulsed doses, octreotide, besides reducing the perception of rectal distension, accelerates intestinal transit, although other evidence disputes such an effect...
  17. ncbi request reprint Does the learning phase influence the late outcome of patients with gastroesophageal reflux disease after laparoscopic fundoplication?
    S Contini
    Department of Surgery, School of Medicine and Dentistry, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    Surg Endosc 18:266-71. 2004
    ..The aim of this study was to verify whether the initial experience in laparoscopic antireflux surgery could also influence the late clinical outcome...
  18. ncbi request reprint Improving opportunities for effective management of gastro-oesophageal reflux disease
    S Vigneri
    Department of Internal Medicine, University of Palermo, Italy
    Dig Liver Dis 33:720-30. 2001
    ..Clinical trials for initial and long-term treatment across the gastro-oesophageal reflux disease spectrum, have clearly demonstrated the superiority of esomeprazole over omeprazole, even if tolerability and safety are very similar...
  19. ncbi request reprint Effects of tablet and effervescent formulations of ranitidine 75 mg and cimetidine 200 mg on gastric acidity and oesophageal acid exposure in healthy humans
    S Bruley des Varannes
    Department of Gastroenterology and Hepatology, College of Medicine, University of Nantes, France
    Aliment Pharmacol Ther 12:1155-61. 1998
    ..Because of their tolerance and safety, low doses of H2-receptor antagonists are now increasingly used in some countries for self-care medication of gastro-oesophageal reflux symptoms...
  20. doi request reprint Rifaximin in the management of colonic diverticular disease
    Giovanni Latella
    Department of Internal Medicine, Gastroenterology Unit, University of L Aquila, Piazza Salvatore Tommasi, 1 Coppito, 67100 L Aquila, Italy
    Expert Rev Gastroenterol Hepatol 3:585-98. 2009
    ..Recent studies have shown some evidence of synergy between rifaximin and mesalazine and suggest that a combined treatment could be worthwhile in selected subsets of patients with diverticular disease...
  21. ncbi request reprint Dysphagia aortica: a neglected symptom of aortoesophageal fistula
    S Contini
    Department of Surgical Sciences, School of Medicine and Dentistry, University of Parma, Maggiore University Hospital, Via Gramsci 14, Italy
    Dig Liver Dis 38:51-4. 2006
    ....
  22. ncbi request reprint Effect of cimetropium bromide and other antispasmodic compounds on in vitro guinea-pig gallbladder
    C Scarpignato
    Institute of Pharmacology, School of Medicine and Dentistry, University of Parma, Italy
    Methods Find Exp Clin Pharmacol 11:323-9. 1989
    ....
  23. ncbi request reprint Quality of life for patients with gastroesophageal reflux disease 2 years after laparoscopic fundoplication. Evaluation of the results obtained during the initial experience
    S Contini
    Department of General Surgery and Organ Transplantation, School of Medicine and Dentistry, University of Parma, Maggiore University Hospital, Via Gramsci 14, 43100 Parma, Italy
    Surg Endosc 16:1555-60. 2002
    ..The aim of this study was to compare the preoperative and medium-term postoperative HRQL in patients submitted to laparoscopic fundoplication during the initial experience to verify its possible influence on HRQL outcomes...
  24. ncbi request reprint Endoscopic treatment of gastro-oesophageal reflux disease (GORD): a systematic review
    S Contini
    Department of Surgery, School of Medicine and Dentistry, University of Parma, Parma, Italy
    Dig Liver Dis 35:818-38. 2003
    ..Moreover, appropriate trials in dedicated centres should be carried out to assure that the enthusiasm commonly associated with new technology is justified and can be generalized to open-access endoscopists...
  25. ncbi request reprint Can gangrenous cholecystitis be prevented?: a plea against a "wait and see" attitude
    S Contini
    Department of Surgery, School of Medicine and Dentistry, University of Parma, Parma, Italy
    J Clin Gastroenterol 38:710-6. 2004
    ..Aim of the study is to assess the therapeutic attitude in patients with histologically proved gangrenous cholecystitis, to find out whether it could play a role in the progression of the inflammatory condition...
  26. ncbi request reprint Rifaximin, a peculiar rifamycin derivative: established and potential clinical use outside the gastrointestinal tract
    Iva Pelosini
    Laboratory of Clinical Pharmacology, Department of Human Anatomy, Pharmacology and Forensic Sciences, School of Medicine and Dentistry, University of Parma, Parma, Italy
    Chemotherapy 51:122-30. 2005
    ..e. chlortetracycline or oxytetracycline), the usefulness of rifaximin in BV and periodontal disease needs to be further studied in well-designed clinical trials...
  27. doi request reprint Proton pump inhibitors in GORD An overview of their pharmacology, efficacy and safety
    Vincenzo Savarino
    Division of Gastroenterology, Department of Internal Medicine, University of Genoa, Italy
    Pharmacol Res 59:135-53. 2009
    ..This safety profile is similar across the various PPIs used in clinical practice and is extended to children and pregnant women, where they do not present any major teratogenic risk...
  28. doi request reprint Corrosive oesophageal strictures in children: outcomes after timely or delayed dilatation
    S Contini
    Department of Surgical Sciences, School of Medicine and Dentistry, University of Parma, Italy
    Dig Liver Dis 41:263-8. 2009
    ....
  29. ncbi request reprint Eradication of Helicobacter pylori: are rifaximin-based regimens effective?
    Antonio Gasbarrini
    Department of Internal Medicine, Gemelli University Hospital, Catholic University of Sacred Heart, Rome, Italy
    Digestion 73:129-35. 2006
    ....
  30. ncbi request reprint Management of colonic diverticular disease
    Giuseppe Frieri
    Gastroenterology Unit, School of Medicine and Dentistry, University of L Aquila, L Aquila, Italy
    Digestion 73:58-66. 2006
    ..It is indicated in diffuse peritonitis, abscesses, fistulas, stenosis and after the second to fourth attack of uncomplicated diverticulitis. Young people and immunocompromised patients are more likely to be operated...
  31. ncbi request reprint Dysphagia and clinical outcome after laparoscopic Nissen or Rossetti fundoplication: sequential prospective study
    Sandro Contini
    Department of General Surgery and Organ Transplantation, School of Medicine and Dentistry, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    World J Surg 26:1106-11. 2002
    ..Complete fundic mobilization should therefore be advised to reduce the incidence of early troublesome dysphagia...
  32. ncbi request reprint Treatment of functional bowel disorders: is there room for antibiotics?
    Gino Roberto Corazza
    First Department of Internal Medicine, School of Medicine and Dentistry, University of Pavia, Pavia, Italy
    Digestion 73:38-46. 2006
    ....
  33. ncbi request reprint 'Rescue' therapies for the management of Helicobacter pylori infection
    Francesco Di Mario
    Section of Gastroenterology, Department of Clinical Sciences, School of Medicine and Dentistry, University of Parma, Parma, Italy
    Dig Dis 24:113-30. 2006
    ..Finally, in more than one H. pylori treatment failure, non-antimicrobial add-on medications (such as lactoferrin, probiotics and others) could be used with the aim either to improve the eradication rate or to minimize side effects...
  34. ncbi request reprint Microbial flora in NSAID-induced intestinal damage: a role for antibiotics?
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, Zaragoza, Spain
    Digestion 73:136-50. 2006
    ..The availability of poorly absorbed and effective antibiotics, like rifaximin, may represent an attractive alternative to prevent or limit NSAID-associated intestinal damage...
  35. ncbi request reprint Advances in GI pharmacology and therapeutics
    Carmelo Scarpignato
    Dig Dis 24:7-10. 2006