R Sarzani

Summary

Country: Italy

Publications

  1. doi request reprint Endocannabinoids, blood pressure and the human heart
    R Sarzani
    Department of Internal Medicine, University of Ancona Politecnica delle Marche, Hypertension Excellence Centre ESH, University Hospital Ospedali Riuniti, Ancona, Italy
    J Neuroendocrinol 20:58-62. 2008
  2. doi request reprint Angiotensinogen promoter variants influence gene expression in human kidney and visceral adipose tissue
    R Sarzani
    Department of Internal Medicine and Cardiovascular Disease, University of Ancona Politecnica delle Marche, Ancona, Italy
    J Hum Hypertens 24:213-9. 2010
  3. doi request reprint The clinical significance of metabolic syndrome in hypertension: metabolic syndrome increases cardiovascular risk : the contrary position
    Riccardo Sarzani
    Department of Internal Medicine and Hypertension Excellence Centre, University of Ancona Politecnica delle Marche, University Hospital Ospedali Riuniti, Ancona, Via Conca, n 71, 60131, Ancona, Italy
    High Blood Press Cardiovasc Prev 15:59-62. 2008
  4. doi request reprint Plasma aldosterone is increased in class 2 and 3 obese essential hypertensive patients despite drug treatment
    Riccardo Sarzani
    Department of Clinical and Molecular Sciences, Hypertension Excellence Centre of the European Society of Hypertension, University Hospital Ospedali Riuniti, University Politecnica delle Marche, Ancona, Italy
    Am J Hypertens 25:818-26. 2012
  5. doi request reprint Renin-angiotensin system, natriuretic peptides, obesity, metabolic syndrome, and hypertension: an integrated view in humans
    Riccardo Sarzani
    Department of Internal Medicine, Centre for Atherosclerosis and Metabolic Syndrome Hypertension Excellence Centre of the European Society of Hypertension, University of Ancona Politecnica delle Marche, Ancona, Italy
    J Hypertens 26:831-43. 2008
  6. ncbi request reprint The functional HERG variant 897T is associated with Conn's adenoma
    Riccardo Sarzani
    Department of Internal Medicine, Universita Politecnica delle Marche, Ancona, Italy
    J Hypertens 24:479-87. 2006
  7. doi request reprint A human fatty acid amide hydrolase (FAAH) functional gene variant is associated with lower blood pressure in young males
    Riccardo Sarzani
    Department of Internal Medicine, University of Ancona Politecnica delle Marche, Ancona, Italy
    Am J Hypertens 21:960-3. 2008
  8. doi request reprint Altered pattern of cannabinoid type 1 receptor expression in adipose tissue of dysmetabolic and overweight patients
    Riccardo Sarzani
    Department of Internal Medicine, University of Ancona, Politecnica delle Marche, 60131 Ancona, Italy
    Metabolism 58:361-7. 2009
  9. doi request reprint Carotid artery atherosclerosis in hypertensive patients with a functional LDL receptor-related protein 6 gene variant
    R Sarzani
    Department of Internal Medicine, Hypertension Excellence Centre of the European Society of Hypertension, University Politecnica delle Marche, Ancona, Italy
    Nutr Metab Cardiovasc Dis 21:150-6. 2011
  10. ncbi request reprint Angiotensin II stimulates and atrial natriuretic peptide inhibits human visceral adipocyte growth
    R Sarzani
    Department of Internal Medicine, University of Ancona Politecnica delle Marche, Ancona, Italy
    Int J Obes (Lond) 32:259-67. 2008

Collaborators

Detail Information

Publications21

  1. doi request reprint Endocannabinoids, blood pressure and the human heart
    R Sarzani
    Department of Internal Medicine, University of Ancona Politecnica delle Marche, Hypertension Excellence Centre ESH, University Hospital Ospedali Riuniti, Ancona, Italy
    J Neuroendocrinol 20:58-62. 2008
    ..Time (and much more work) will tell us much more about cannabinoids and the human heart...
  2. doi request reprint Angiotensinogen promoter variants influence gene expression in human kidney and visceral adipose tissue
    R Sarzani
    Department of Internal Medicine and Cardiovascular Disease, University of Ancona Politecnica delle Marche, Ancona, Italy
    J Hum Hypertens 24:213-9. 2010
    ..Our results support the hypothesis that some human AGT promoter variants influence transcriptional activity in a tissue-specific way in humans...
  3. doi request reprint The clinical significance of metabolic syndrome in hypertension: metabolic syndrome increases cardiovascular risk : the contrary position
    Riccardo Sarzani
    Department of Internal Medicine and Hypertension Excellence Centre, University of Ancona Politecnica delle Marche, University Hospital Ospedali Riuniti, Ancona, Via Conca, n 71, 60131, Ancona, Italy
    High Blood Press Cardiovasc Prev 15:59-62. 2008
    ..Non-optimal blood pressure and hypertension are likely to be the real 'vasculometabolic' syndrome that affects most humans, with the rare exceptions to be found in no-salt, no-fat cultures...
  4. doi request reprint Plasma aldosterone is increased in class 2 and 3 obese essential hypertensive patients despite drug treatment
    Riccardo Sarzani
    Department of Clinical and Molecular Sciences, Hypertension Excellence Centre of the European Society of Hypertension, University Hospital Ospedali Riuniti, University Politecnica delle Marche, Ancona, Italy
    Am J Hypertens 25:818-26. 2012
    ....
  5. doi request reprint Renin-angiotensin system, natriuretic peptides, obesity, metabolic syndrome, and hypertension: an integrated view in humans
    Riccardo Sarzani
    Department of Internal Medicine, Centre for Atherosclerosis and Metabolic Syndrome Hypertension Excellence Centre of the European Society of Hypertension, University of Ancona Politecnica delle Marche, Ancona, Italy
    J Hypertens 26:831-43. 2008
    ..We propose herein an integrated view of the dysregulation of these two antagonistic systems in human obesity complicated with hypertension, metabolic syndrome, and increased cardiovascular risk...
  6. ncbi request reprint The functional HERG variant 897T is associated with Conn's adenoma
    Riccardo Sarzani
    Department of Internal Medicine, Universita Politecnica delle Marche, Ancona, Italy
    J Hypertens 24:479-87. 2006
    ....
  7. doi request reprint A human fatty acid amide hydrolase (FAAH) functional gene variant is associated with lower blood pressure in young males
    Riccardo Sarzani
    Department of Internal Medicine, University of Ancona Politecnica delle Marche, Ancona, Italy
    Am J Hypertens 21:960-3. 2008
    ..This study investigates the relationship among FAAH P129T alleles and cardiovascular features in YMs at baseline and after 9-year follow-up, and in older male obese hypertensive (OH) patients, in whom the EC system (ECS) is overactive...
  8. doi request reprint Altered pattern of cannabinoid type 1 receptor expression in adipose tissue of dysmetabolic and overweight patients
    Riccardo Sarzani
    Department of Internal Medicine, University of Ancona, Politecnica delle Marche, 60131 Ancona, Italy
    Metabolism 58:361-7. 2009
    ..007). Visceral adipose CB1 expression correlated with BMI. Overweight patients and those with MetS showed a CB1 expression pattern supporting a CB1-mediated overactivity of the endocannabinoid system in human VAT...
  9. doi request reprint Carotid artery atherosclerosis in hypertensive patients with a functional LDL receptor-related protein 6 gene variant
    R Sarzani
    Department of Internal Medicine, Hypertension Excellence Centre of the European Society of Hypertension, University Politecnica delle Marche, Ancona, Italy
    Nutr Metab Cardiovasc Dis 21:150-6. 2011
    ..We investigated whether the common 1062V LRP6 variant was related to carotid artery atherosclerosis (CAA) in hypertensive patients...
  10. ncbi request reprint Angiotensin II stimulates and atrial natriuretic peptide inhibits human visceral adipocyte growth
    R Sarzani
    Department of Internal Medicine, University of Ancona Politecnica delle Marche, Ancona, Italy
    Int J Obes (Lond) 32:259-67. 2008
    ..Well-differentiated and stabilized primary cultures of human visceral mature adipocytes (MA) and in vitro-differentiated preadipocytes (DPA) were used as a model to study regulation of VAT expansion...
  11. ncbi request reprint A novel promoter variant of the natriuretic peptide clearance receptor gene is associated with lower atrial natriuretic peptide and higher blood pressure in obese hypertensives
    R Sarzani
    Institute of Clinical Medicine, University of Ancona, Italy
    J Hypertens 17:1301-5. 1999
    ..The objectives of the present study were to sequence the human 5'-flanking regulatory region of NPRC, to identify allelic variants and their frequencies, and to study the genotype/phenotype correlation in hypertensive patients...
  12. ncbi request reprint Aldosterone synthase alleles and cardiovascular phenotype in young adults
    R Sarzani
    Institute of Clinical Medicine, University of Ancona, Ancona, Italy
    J Hum Hypertens 17:859-64. 2003
    ..01), in the codominant model. In conclusion, the CYP11B2 C(-344)T polymorphism appears to have a slight role in the cardiovascular phenotype of young healthy adults, even if these genotype/phenotype relationships might change with ageing...
  13. ncbi request reprint Expression of potassium channel isoforms mRNA in normal human adrenals and aldosterone-secreting adenomas
    R Sarzani
    Department of Internal Medicine, Polytechnical University of Marche, Ancona, University of Rome La Sapienza, Rome, Italy
    J Endocrinol Invest 29:147-53. 2006
    ..This different expression pattern of KCNQ1 isoforms in NCI-H295 cell line with the lack of the mRNA for the dominant-negative KCNQ1 isoform 2 supports the involvement of voltage-gated K+ channel in cell proliferation...
  14. ncbi request reprint Cardiovascular effects of sildenafil in hypertensive men with erectile dysfunction and different alleles of the type 5 cGMP-specific phosphodiesterase (PDE5)
    F Salvi
    Department of Internal Medicine, Polytechnical University of Marche, Ancona, Italy
    Int J Impot Res 16:412-7. 2004
    ..Further studies are necessary to define the role of this polymorphism and to study the genetic predisposition for EH with ED...
  15. ncbi request reprint Cardiovascular phenotype of young adults and angiotensinogen alleles
    R Sarzani
    Institute of Clinical Medicine, University of Ancona, Ancona, Italy
    J Hypertens 19:2171-8. 2001
    ..A young adult population can be used as a model to study genotype/phenotype associations between AGT (-6) variants and cardiovascular variables...
  16. ncbi request reprint Role of the natriuretic peptide system in lipogenesis/lipolysis
    P Dessi-Fulgheri
    Clinica di Medicina Interna, Azienda Ospedaliera Umberto I, Via Conca, 60020 Ancona, Italy
    Nutr Metab Cardiovasc Dis 13:244-9. 2003
    ..This effect is mediated by the interaction of NP with its active receptors through guanylyl cyclase activation and cGMP production. This review will briefly focus on the new aspects of NP pathophysiology in man...
  17. ncbi request reprint Absence of somatic mutations in natriuretic peptide receptor type A gene in human aldosterone-secreting adenomas
    R Sarzani
    Department of Internal Medicine, University of Ancona, Ancona, Italy
    J Mol Endocrinol 31:317-26. 2003
    ..The polymorphism identified in the 3'-UTR might affect mRNA stability resulting in lower receptor synthesis, but it is not likely to confer a predisposition to the development of aldosteronomas...
  18. doi request reprint TCF7L2 alleles and metabolic syndrome in non-diabetic obese hypertensive patients
    R Sarzani
    J Hum Hypertens 22:373-5. 2008
  19. ncbi request reprint Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene
    P Madeddu
    Clinica Medica, University of Sassari, Italy
    Circulation 96:3570-8. 1997
    ..To evaluate the role of kinins in the regulation of cardiovascular function, we studied the phenotype of a mouse strain with disruption of the bradykinin B2-receptor gene (Bk 2r-/-)...
  20. ncbi request reprint Massive spontaneous perirenal hematoma and accelerated hypertension in a patient with polyarteritis nodosa
    D Minardi
    Institute of Urology, University of Ancona Medical School, Umberto I Hospital, Piazza Cappelli 1, I 60121 Ancona, Italy
    Urol Int 70:227-31. 2003
    ..We hypothesize a relationship between reactivation of polyarteritis nodosa and treatment with rifampicin and isoniazid...
  21. ncbi request reprint Differentiation and growth of vascular smooth muscle cells in experimental hypertension
    P Pauletto
    Institute of Clinical Medicine, University of Padova, Italy
    Am J Hypertens 7:661-74. 1994
    ..Thus, these factors not only play a specific role in the regulation of blood pressure, but also are likely to be responsible for the remodeling of the arterial wall in hypertension...